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HLA class II-Restricted CD8+ T cells in HIV-1 Virus Controllers.

Publication ,  Journal Article
Nyanhete, TE; Frisbee, AL; Bradley, T; Faison, WJ; Robins, E; Payne, T; Freel, SA; Sawant, S; Weinhold, KJ; Wiehe, K; Haynes, BF; Ferrari, G ...
Published in: Sci Rep
July 15, 2019

A paradigm shifting study demonstrated that induction of MHC class E and II-restricted CD8+ T cells was associated with the clearance of SIV infection in rhesus macaques. Another recent study highlighted the presence of HIV-1-specific class II-restricted CD8+ T cells in HIV-1 patients who naturally control infection (virus controllers; VCs). However, questions regarding class II-restricted CD8+ T cells ontogeny, distribution across different HIV-1 disease states and their role in viral control remain unclear. In this study, we investigated the distribution and anti-viral properties of HLA-DRB1*0701 and DQB1*0501 class II-restricted CD8+ T cells in different HIV-1 patient cohorts; and whether class II-restricted CD8+ T cells represent a unique T cell subset. We show that memory class II-restricted CD8+ T cell responses were more often detectable in VCs than in chronically infected patients, but not in healthy seronegative donors. We also demonstrate that VC CD8+ T cells inhibit virus replication in both a class I- and class II-dependent manner, and that in two VC patients the class II-restricted CD8+ T cells with an anti-viral gene signature expressed both CD4+ and CD8+ T cell lineage-specific genes. These data demonstrated that anti-viral memory class II-restricted CD8+ T cells with hybrid CD4+ and CD8+ features are present during natural HIV-1 infection.

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Published In

Sci Rep

DOI

EISSN

2045-2322

Publication Date

July 15, 2019

Volume

9

Issue

1

Start / End Page

10165

Location

England

Related Subject Headings

  • Virus Replication
  • Viral Load
  • Male
  • Humans
  • Histocompatibility Antigens Class II
  • HLA-DRB1 Chains
  • HLA-DQ beta-Chains
  • HIV-1
  • HIV Seropositivity
  • HIV Infections
 

Citation

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Nyanhete, T. E., Frisbee, A. L., Bradley, T., Faison, W. J., Robins, E., Payne, T., … Tomaras, G. D. (2019). HLA class II-Restricted CD8+ T cells in HIV-1 Virus Controllers. Sci Rep, 9(1), 10165. https://doi.org/10.1038/s41598-019-46462-8
Nyanhete, Tinashe E., Alyse L. Frisbee, Todd Bradley, William J. Faison, Elizabeth Robins, Tamika Payne, Stephanie A. Freel, et al. “HLA class II-Restricted CD8+ T cells in HIV-1 Virus Controllers.Sci Rep 9, no. 1 (July 15, 2019): 10165. https://doi.org/10.1038/s41598-019-46462-8.
Nyanhete TE, Frisbee AL, Bradley T, Faison WJ, Robins E, Payne T, et al. HLA class II-Restricted CD8+ T cells in HIV-1 Virus Controllers. Sci Rep. 2019 Jul 15;9(1):10165.
Nyanhete, Tinashe E., et al. “HLA class II-Restricted CD8+ T cells in HIV-1 Virus Controllers.Sci Rep, vol. 9, no. 1, July 2019, p. 10165. Pubmed, doi:10.1038/s41598-019-46462-8.
Nyanhete TE, Frisbee AL, Bradley T, Faison WJ, Robins E, Payne T, Freel SA, Sawant S, Weinhold KJ, Wiehe K, Haynes BF, Ferrari G, Li Q-J, Moody MA, Tomaras GD. HLA class II-Restricted CD8+ T cells in HIV-1 Virus Controllers. Sci Rep. 2019 Jul 15;9(1):10165.

Published In

Sci Rep

DOI

EISSN

2045-2322

Publication Date

July 15, 2019

Volume

9

Issue

1

Start / End Page

10165

Location

England

Related Subject Headings

  • Virus Replication
  • Viral Load
  • Male
  • Humans
  • Histocompatibility Antigens Class II
  • HLA-DRB1 Chains
  • HLA-DQ beta-Chains
  • HIV-1
  • HIV Seropositivity
  • HIV Infections