Journal ArticleThe journal of pain · December 2024
The count of locations with chronic pain is widely used in research and clinical practice. However, this approach might be too simplistic to fully capture the complexity of chronic pain experiences. This study identified prevalent patterns of chronic pain ...
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Journal ArticleAnnals of epidemiology · December 2024
BackgroundThe Lancet Commission has highlighted 12 modifiable risk factors for dementia. However, the effects of addressing these risk factors among the heterogeneous older adult population is not fully understood. We compared the association betw ...
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Journal ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences · November 2024
BackgroundMounting evidence suggests that cognitive impairment is strongly associated with disability in activities of daily living (ADL disability) and long-term care (LTC) costs. However, studies forecasting future LTC costs often overlook these ...
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Journal ArticleGeroScience · November 2024
The availability of proteomics data in large, population-based cohort studies offers an unprecedented opportunity to understand the onset and progression of aging-related diseases and syndromes. We examined the proteomic signature of the onset of frailty a ...
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Journal ArticleScientific reports · October 2024
Cardiovascular disease (CVD) is a major chronic disease worldwide and its risk factors have long been investigating in epidemiological studies. Our study aims to develop a body composition-based risk score and integrate it into the Framingham Risk Score (F ...
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Journal ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences · July 2024
BackgroundThe role of social environment, that is, the aggregate effect of social determinants of health (SDOHs), in determining dementia is unclear.MethodsWe developed a novel polysocial risk score for dementia based on 19 SDOH among 5 1 ...
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Journal ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences · April 2024
BackgroundThe relationship between subjective and objective health is complex and not always matched. Although frailty and self-rated health (SRH) have been separately associated with adverse outcomes, their joint effects remained unclear.Meth ...
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Journal ArticleAmerican journal of epidemiology · April 2024
Social determinants of health (SDOH) encompass the social environmental factors and lived experiences that collectively shape an individual's health. Recently, the polysocial score approach has been introduced as an innovative method for capturing the cumu ...
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Journal ArticleThe journal of nutrition, health & aging · February 2024
ObjectivesThis study aimed to explore the associations between different types of meat consumption and mortality risk among people with frailty.DesignLongitudinal study.Setting and participantsWe included 19,913 physically frail ...
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Journal ArticleAge and ageing · January 2024
BackgroundSarcopenia is an important prognostic factor, but its optimal screening methods remain challenging. Several new indices developed based on serum creatinine (Cr) and cystatin C (CysC) have been proposed to be diagnostic biomarkers for sar ...
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Journal ArticleInnovation in aging · January 2024
Background and objectivesWith the global population aging at an unprecedented pace, the imminent surge in falls and fall-induced injuries necessitates urgent attention. Innovative assistive technologies are crucial in addressing this daunting chal ...
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Journal ArticleInnovation in aging · January 2024
Background and objectivesThe racial or ethnic disparity in the burden of dementia exists among older adults in the United States, whereas gaps remain in understanding the synergic effect of multiple social determinants of health on diminishing thi ...
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Journal ArticleEuropean journal of public health · October 2023
BackgroundRecently, the World Health Organization (WHO) released an updated global guideline on physical activity and sedentary behavior, including recommendations for sub-populations living with chronic conditions or disabilities. We aimed to exa ...
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Journal ArticleJournal of the American Medical Directors Association · August 2023
ObjectivesTo date, no consensus has been reached regarding the role of klotho in the development of frailty. This study aimed to examine the relationship between serum klotho and physical frailty and to explore potential age, sex, and racial/ethni ...
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Journal ArticleAge and ageing · August 2023
ObjectiveThis review aimed to summarise the diagnostic accuracy of screening tools for sarcopenia.MethodsWe conducted a systematic review along with a critical appraisal of published studies on screening tools for sarcopenia. We assessed ...
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Journal ArticleMaturitas · June 2023
ObjectivesRacial and ethnic disparities in disability in activities of daily living (ADL) continue to be a public concern. We evaluated whether the polysocial score approach could provide a more comprehensive method for modifying racial and ethnic ...
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Journal ArticleHealth science reports · June 2023
Background and aimsFew studies have meta-analyzed different prognostic models developed for older adults, especially nursing home residents. We aimed to systematically review and meta-analyze the performance of all published models that predicted ...
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Journal ArticleGlob Health Res Policy · April 6, 2023
BACKGROUND: There has been considerable progress in developing global health education and research in China. Nevertheless, evidence of the progress of Chinese universities' contributions to global health research is limited. More efforts are needed to dep ...
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Journal ArticleJournal of the American Heart Association · March 2023
Background Myocardial infarction (MI) is a significant clinical and public health problem worldwide. However, little research has assessed the interplay between genetic susceptibility and social environment in the development of MI. Methods and Results Dat ...
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Journal ArticleJournal of the American Medical Directors Association · February 2023
ObjectivesThe aim of this study was to estimate and project the trend in long-term care (LTC) costs for home and community-based services as a percentage of gross domestic product in China between 2005 and 2050.DesignLongitudinal.Sett ...
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Journal ArticleAgeing research reviews · January 2023
ObjectiveTo provide an overview of prediction models for the risk of major depressive disorder (MDD) among older adults.MethodsWe conducted a systematic review combined with a meta-analysis and critical appraisal of published studies on e ...
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Journal ArticleBMC geriatrics · January 2023
BackgroundInformal caregivers of older adults with dementia may experience substantial burdens during their caregiving process, especially when caring for older adults with other comorbid conditions. This study evaluated whether and how comorbidit ...
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Journal ArticleBMJ Open · November 16, 2022
OBJECTIVES: To measure the disease burden of ageing based on age-related diseases (ARDs), the sex and regional disparities and the impact of health resources allocation on the burden in China. DESIGN: A national comparative study based on Global Burden of ...
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Journal ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences · November 2022
BackgroundFew studies have examined the association of neighborhood environment and mortality among community-dwelling older populations. Geographic Information Systems-based measures of neighborhood physical environment may provide new insights o ...
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Journal ArticleAge and ageing · August 2022
Objectiveto identify multimorbidity patterns among middle-aged and older adults in China and examine how these patterns are associated with incident disability and recovery of independence.Methodsdata were from The China Health and Retire ...
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Journal ArticleBMC geriatrics · June 2022
BackgroundInappropriate prescribing of medications and polypharmacy among older adults are associated with a wide range of adverse outcomes. It is critical to understand the attitudes towards deprescribing-reducing the use of potentially inappropr ...
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Journal ArticleBMC geriatrics · February 2022
BackgroundsEmerging evidence suggested that indoor air pollution caused long-term adverse effects on cognitive function among older adults who spend more than 85% of their time indoors. Although high indoor ventilation can mitigate the effect of i ...
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Journal ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences · January 2022
BackgroundLittle is known about long-term lipid variability in young adulthood in relation to cognitive function and brain integrity in midlife.MethodWe studied 3 328 adults from the Coronary Artery Risk Development in Young Adults. We de ...
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Journal ArticleThe Journal of frailty & aging · January 2022
BackgroundPhysical resilience is an emerging concept within the context of aging and geriatric medicine, and we previously developed and validated one such indicator based on the mismatch between persons' frailty level and multimorbidity burden. W ...
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Journal ArticleJournal of affective disorders · September 2021
BackgroundA growing body of literature suggests that early life circumstances can influence mental health throughout the lifespan. However, how these early life circumstances cumulatively contribute to depression in old age is not completely under ...
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Journal ArticleBMJ open · August 2021
BackgroundAllostatic load (AL) has shown that high burden of AL is associated with increased risk of adverse outcomes, but little attention has been paid to China with largest ageing population in the world.ObjectiveThis study is to exami ...
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Journal ArticleJournal of general internal medicine · July 2021
BackgroundWhether high burden of subclinical vascular disease (SVD) is associated with increased premature mortality among middle-aged adults is not adequately understood. The association of midlife SVD burden with premature mortality among middle ...
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Journal ArticleBMC geriatrics · April 2021
BackgroundSocio-demographic transitions have dramatically changed the traditional family care settings in China, caused unmet care needs among older adults. However, whether different primary caregiver types have different influences on disabled o ...
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Journal ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences · February 2021
BackgroundMany traditional cardiovascular risk factors do not predict survival to very old age. Studies have shown associations of estimated glomerular filtration rate (eGFR) and N-terminal pro-B-type natriuretic peptide (NT-pro-BNP) with cardiova ...
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Journal ArticleThe journals of gerontology. Series B, Psychological sciences and social sciences · January 2021
ObjectiveHandgrip strength, an indicator of overall muscle strength, has been found to be associated with slower rate of cognitive decline and decreased risk for cognitive impairment and dementia. However, evaluating the replicability of associati ...
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Journal Article · 2021
Background Biological age (BA) has been accepted as a more accurate proxy of aging than chronological age (CA). This study aimed to use machine learning (ML) algorithms to estimate BA in the Chinese population. Methods We used data from 9 ...
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Journal Article · 2021
Background and aim Mortality risk stratification was vital for targeted intervention. This study aimed at building the prediction model of all-cause mortality among Chinese dwelling elderly with different methods including regression models and ma ...
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Journal ArticleAgeing research reviews · December 2020
One of the key issues facing public healthcare is the global trend of an increasingly ageing society which continues to present policy makers and caregivers with formidable healthcare and socio-economic challenges. Ageing is the primary contributor to a br ...
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Journal ArticleBMJ open · December 2020
ObjectivesWe aimed to understand the prevalence of reduced kidney function in China by sociodemographics and geographical region, and to examine health correlates of reduced kidney function.DesignCross-sectional study.Setting and part ...
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Journal ArticleBMJ open · October 2020
ObjectivesTo identify the prevalence of anaemia among older adults in China by sociodemographic and geographical regions, and cross-sectionally examine the associations between anaemia and several geriatric outcomes.DesignCross-sectional ...
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Journal ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences · September 2020
BackgroundThe concept of resilience has gained increasing attention in aging research; however, current literature lacks consensus on how to measure resilience. We constructed a novel resilience measure based on the degree of mismatch between pers ...
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Journal ArticleJournal of the American Medical Directors Association · June 2020
ObjectivesFrailty is an accumulation of deficits characterized by reduced resilience to stressors and increased vulnerability to adverse outcomes. There is evolving evidence on the health benefits of residential greenness, but little is known abou ...
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Journal ArticleJournal of the American Medical Directors Association · June 2020
ObjectivesThe purpose of this study was to examine whether frailty could explain variability in healthcare expenditure beyond multimorbidity and disability among Chinese older adults.DesignCross-sectional.Setting and participants ...
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Journal ArticleWiener klinische Wochenschrift · June 2020
BackgroundEvidence from longitudinal studies linking frailty and outcome after acute coronary syndrome (ACS) is mixed. This systematic review and meta-analysis aimed to examine whether frailty is a predictor of all-cause mortality and hospital rea ...
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Journal ArticleBMC geriatrics · March 2020
BackgroundsLittle is known about the role of frailty in the recovery process of disability among older adults. We examined the association between frailty and recovery from activities of daily living (ADL) and instrumental ADL (IADL) disability am ...
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Journal Article · 2020
Background: Allostatic load, as multiple biomarker measures of ‘wear and tear’ on physiological systems, has shown some promise that high burden of AL is associated with increased risk of adverse outcomes, but little attention has been paid to Ch ...
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Journal ArticleJournal of the American Medical Directors Association · December 2019
ObjectiveEpidemiologic studies have reported inconsistent findings about the association between sleep duration and the risk of dementia. We aimed to clarify this association by method of meta-analysis.DesignSystematic review and meta-ana ...
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Journal ArticleBMC geriatrics · December 2019
BackgroundFrailty is a clinically recognizable state of reduced resilience to stressors and increased vulnerability to adverse outcomes. The majority of studies have focused on the prevalence and risk factors of frailty, while the incidence of fra ...
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Journal ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences · October 2019
BackgroundSubstantial research is dedicated to understanding the aging-related dynamics among individual differences in level, change, and variation across physical and cognitive abilities. Evaluating replicability and synthesizing these findings ...
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Journal ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences · March 2019
BackgroundDisability in activities of daily living (ADLs) is a dynamic process and transitions among different disability states are common. However, little is known about factors affecting recovery from disability. We examined the association bet ...
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Journal ArticleAmerican journal of epidemiology · August 2018
Frailty is an age-related clinical syndrome of decreased resilience to stressors. Among numerous assessments of frailty, the frailty phenotype (FP) scale proposed by Fried et al. has been the most widely used. We aimed to develop a continuous frailty scale ...
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Journal ArticleJournal of the American Geriatrics Society · July 2018
ObjectivesTo characterize the distribution of an index of healthy aging-the Chinese Healthy Aging Index (CHAI)-in Chinese adults aged 60 and older according to sociodemographic characteristics and geographic region and to examine the association b ...
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Journal ArticleJournal of behavioral medicine · February 2018
While individual-level determinants of health, such as education and income, have been well documented among breast cancer survivors, little is known about the role of neighborhood context on survivorship outcomes among this population. The present study e ...
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Journal ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences · December 2017
BackgroundFrailty is an age-related clinical syndrome of decreased resilience to stressors and is associated with numerous adverse outcomes. Although there is preponderance of literature on frailty in developed countries, limited investigations ha ...
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Journal ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences · October 2017
BackgroundComorbidity indices that are based on clinically recognized disease do not capture the full spectrum of health. The Healthy Aging Index (HAI) was recently developed to describe a wider range of health and disease across multiple organ sy ...
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Journal ArticleJournal of the American Geriatrics Society · July 2017
ObjectiveTo examine whether grip strength, gait speed, and the combination of the two physical functioning measures modified the association of systolic BP (SBP) and diastolic BP (DBP) with mortality.DesignNationally representative cohort ...
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Journal ArticleAmerican journal of hypertension · February 2017
BackgroundLevel of blood pressure (BP) is strongly associated with cardiovascular (CV) events and mortality. However, it is questionable whether mean BP can fully capture BP-related vascular risk. Increasing attention has been given to the value o ...
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Journal ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences · December 2016
BackgroundThe present study aimed to (i) evaluate previous observations that the association of blood pressure (BP) with outcomes varies by gait speed and (ii) evaluate the association of subsequent changes in BP and cardiovascular risk.Method ...
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Journal ArticleJournal of epidemiology and community health · September 2016
BackgroundRetirement is an important transitional process in later life. Despite a large body of research examining the impacts of health on retirement, questions still remain regarding the association of retirement age with survival. We aimed to ...
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