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Chenkai Wu

Assistant Professor of Global Health at Duke Kunshan University
DKU Faculty

Selected Publications


Social environment, lifestyle, and genetic predisposition with dementia risk: A long-term longitudinal study among older adults.

Journal Article The journals of gerontology. Series A, Biological sciences and medical sciences · May 2024 BackgroundThe role of social environment, i.e., the aggregate effect of social determinants of health (SDOHs), in determining dementia is unclear.MethodsWe developed a novel polysocial risk score for dementia based on 19 SDOH among 5,199 ... Full text Cite

Projecting Long-term Care Costs among Older Adults with ADL Disability and Cognitive Impairment in China.

Journal Article The journals of gerontology. Series A, Biological sciences and medical sciences · May 2024 BackgroundMounting evidence suggests that cognitive impairment is strongly associated with difficulties in performing activities of daily living (ADL disability). This study aims to estimate and project the trend in the number of older adults in C ... Full text Cite

Joint Association of Physical Frailty and Self-Rated Health With Mortality Among Community-Dwelling Older Adults.

Journal Article The journals of gerontology. Series A, Biological sciences and medical sciences · April 2024 BackgroundThe relationship between subjective and objective health is complex and not always matched. Although frailty and self-rated health (SRH) have been separately associated with adverse outcomes, their joint effects remained unclear.Meth ... Full text Cite

Associations between meat consumption and all-cause and cause-specific mortality in middle-aged and older adults with frailty.

Journal Article The journal of nutrition, health & aging · February 2024 ObjectivesThis study aimed to explore the associations between different types of meat consumption and mortality risk among people with frailty.DesignLongitudinal study.Setting and participantsWe included 19,913 physically frail ... Full text Cite

Diagnostic test accuracy of serum creatinine and cystatin C-based index for sarcopenia: a systematic review and meta-analysis.

Journal Article Age and ageing · January 2024 BackgroundSarcopenia is an important prognostic factor, but its optimal screening methods remain challenging. Several new indices developed based on serum creatinine (Cr) and cystatin C (CysC) have been proposed to be diagnostic biomarkers for sar ... Full text Cite

Prevalence of sufficient physical activity among general adult population and sub-populations with chronic conditions or disability in the USA.

Journal Article European journal of public health · October 2023 BackgroundRecently, the World Health Organization (WHO) released an updated global guideline on physical activity and sedentary behavior, including recommendations for sub-populations living with chronic conditions or disabilities. We aimed to exa ... Full text Cite

Association between Serum Klotho and Physical Frailty in Middle-Aged and Older Adults: Finding From the National Health and Nutrition Examination Survey.

Journal Article Journal of the American Medical Directors Association · August 2023 ObjectivesTo date, no consensus has been reached regarding the role of klotho in the development of frailty. This study aimed to examine the relationship between serum klotho and physical frailty and to explore potential age, sex, and racial/ethni ... Full text Cite

The accuracy of screening instruments for sarcopenia: a diagnostic systematic review and meta-analysis.

Journal Article Age and ageing · August 2023 ObjectiveThis review aimed to summarise the diagnostic accuracy of screening tools for sarcopenia.MethodsWe conducted a systematic review along with a critical appraisal of published studies on screening tools for sarcopenia. We assessed ... Full text Cite

Examining racial and ethnic differences in disability among older adults: A polysocial score approach.

Journal Article Maturitas · June 2023 ObjectivesRacial and ethnic disparities in disability in activities of daily living (ADL) continue to be a public concern. We evaluated whether the polysocial score approach could provide a more comprehensive method for modifying racial and ethnic ... Full text Cite

Prediction models of all-cause mortality among older adults in nursing home setting: A systematic review and meta-analysis.

Journal Article Health science reports · June 2023 Background and aimsFew studies have meta-analyzed different prognostic models developed for older adults, especially nursing home residents. We aimed to systematically review and meta-analyze the performance of all published models that predicted ... Full text Cite

Trends in global health research among universities in China: a bibliometric analysis.

Journal Article Glob Health Res Policy · April 6, 2023 BACKGROUND: There has been considerable progress in developing global health education and research in China. Nevertheless, evidence of the progress of Chinese universities' contributions to global health research is limited. More efforts are needed to dep ... Full text Link to item Cite

Association of Joint Genetic and Social Environmental Risks With Incident Myocardial Infarction: Results From the Health and Retirement Study.

Journal Article Journal of the American Heart Association · March 2023 Background Myocardial infarction (MI) is a significant clinical and public health problem worldwide. However, little research has assessed the interplay between genetic susceptibility and social environment in the development of MI. Methods and Results Dat ... Full text Cite

Projecting Long-Term Care Costs for Home and Community-Based Services in China from 2005 to 2050.

Journal Article Journal of the American Medical Directors Association · February 2023 ObjectivesThe aim of this study was to estimate and project the trend in long-term care (LTC) costs for home and community-based services as a percentage of gross domestic product in China between 2005 and 2050.DesignLongitudinal.Sett ... Full text Cite

Prediction models for depression risk among older adults: systematic review and critical appraisal.

Journal Article Ageing research reviews · January 2023 ObjectiveTo provide an overview of prediction models for the risk of major depressive disorder (MDD) among older adults.MethodsWe conducted a systematic review combined with a meta-analysis and critical appraisal of published studies on e ... Full text Open Access Cite

Association of dementia comorbidities with caregivers' physical, psychological, social, and financial burden.

Journal Article BMC geriatrics · January 2023 BackgroundInformal caregivers of older adults with dementia may experience substantial burdens during their caregiving process, especially when caring for older adults with other comorbid conditions. This study evaluated whether and how comorbidit ... Full text Cite

Disease burden of ageing, sex and regional disparities and health resources allocation: a longitudinal analysis of 31 provinces in Mainland China.

Journal Article BMJ Open · November 16, 2022 OBJECTIVES: To measure the disease burden of ageing based on age-related diseases (ARDs), the sex and regional disparities and the impact of health resources allocation on the burden in China. DESIGN: A national comparative study based on Global Burden of ... Full text Link to item Cite

Association of Retail Environment and Neighborhood Socioeconomic Status With Mortality Among Community-Dwelling Older Adults in the United States: Cardiovascular Health Study.

Journal Article The journals of gerontology. Series A, Biological sciences and medical sciences · November 2022 BackgroundFew studies have examined the association of neighborhood environment and mortality among community-dwelling older populations. Geographic Information Systems-based measures of neighborhood physical environment may provide new insights o ... Full text Cite

Association of multimorbidity patterns with incident disability and recovery of independence among middle-aged and older adults.

Journal Article Age and ageing · August 2022 Objectiveto identify multimorbidity patterns among middle-aged and older adults in China and examine how these patterns are associated with incident disability and recovery of independence.Methodsdata were from The China Health and Retire ... Full text Cite

Continue or not to continue? Attitudes towards deprescribing among community-dwelling older adults in China.

Journal Article BMC geriatrics · June 2022 BackgroundInappropriate prescribing of medications and polypharmacy among older adults are associated with a wide range of adverse outcomes. It is critical to understand the attitudes towards deprescribing-reducing the use of potentially inappropr ... Full text Cite

Association between indoor ventilation frequency and cognitive function among community-dwelling older adults in China: results from the Chinese longitudinal healthy longevity survey.

Journal Article BMC geriatrics · February 2022 BackgroundsEmerging evidence suggested that indoor air pollution caused long-term adverse effects on cognitive function among older adults who spend more than 85% of their time indoors. Although high indoor ventilation can mitigate the effect of i ... Full text Cite

Social environment, lifestyle, and genetic predisposition with dementia risk: A long-term longitudinal study among older adults.

Journal Article The journals of gerontology. Series A, Biological sciences and medical sciences · May 2024 BackgroundThe role of social environment, i.e., the aggregate effect of social determinants of health (SDOHs), in determining dementia is unclear.MethodsWe developed a novel polysocial risk score for dementia based on 19 SDOH among 5,199 ... Full text Cite

Projecting Long-term Care Costs among Older Adults with ADL Disability and Cognitive Impairment in China.

Journal Article The journals of gerontology. Series A, Biological sciences and medical sciences · May 2024 BackgroundMounting evidence suggests that cognitive impairment is strongly associated with difficulties in performing activities of daily living (ADL disability). This study aims to estimate and project the trend in the number of older adults in C ... Full text Cite

Joint Association of Physical Frailty and Self-Rated Health With Mortality Among Community-Dwelling Older Adults.

Journal Article The journals of gerontology. Series A, Biological sciences and medical sciences · April 2024 BackgroundThe relationship between subjective and objective health is complex and not always matched. Although frailty and self-rated health (SRH) have been separately associated with adverse outcomes, their joint effects remained unclear.Meth ... Full text Cite

Associations between meat consumption and all-cause and cause-specific mortality in middle-aged and older adults with frailty.

Journal Article The journal of nutrition, health & aging · February 2024 ObjectivesThis study aimed to explore the associations between different types of meat consumption and mortality risk among people with frailty.DesignLongitudinal study.Setting and participantsWe included 19,913 physically frail ... Full text Cite

Diagnostic test accuracy of serum creatinine and cystatin C-based index for sarcopenia: a systematic review and meta-analysis.

Journal Article Age and ageing · January 2024 BackgroundSarcopenia is an important prognostic factor, but its optimal screening methods remain challenging. Several new indices developed based on serum creatinine (Cr) and cystatin C (CysC) have been proposed to be diagnostic biomarkers for sar ... Full text Cite

Prevalence of sufficient physical activity among general adult population and sub-populations with chronic conditions or disability in the USA.

Journal Article European journal of public health · October 2023 BackgroundRecently, the World Health Organization (WHO) released an updated global guideline on physical activity and sedentary behavior, including recommendations for sub-populations living with chronic conditions or disabilities. We aimed to exa ... Full text Cite

Association between Serum Klotho and Physical Frailty in Middle-Aged and Older Adults: Finding From the National Health and Nutrition Examination Survey.

Journal Article Journal of the American Medical Directors Association · August 2023 ObjectivesTo date, no consensus has been reached regarding the role of klotho in the development of frailty. This study aimed to examine the relationship between serum klotho and physical frailty and to explore potential age, sex, and racial/ethni ... Full text Cite

The accuracy of screening instruments for sarcopenia: a diagnostic systematic review and meta-analysis.

Journal Article Age and ageing · August 2023 ObjectiveThis review aimed to summarise the diagnostic accuracy of screening tools for sarcopenia.MethodsWe conducted a systematic review along with a critical appraisal of published studies on screening tools for sarcopenia. We assessed ... Full text Cite

Examining racial and ethnic differences in disability among older adults: A polysocial score approach.

Journal Article Maturitas · June 2023 ObjectivesRacial and ethnic disparities in disability in activities of daily living (ADL) continue to be a public concern. We evaluated whether the polysocial score approach could provide a more comprehensive method for modifying racial and ethnic ... Full text Cite

Prediction models of all-cause mortality among older adults in nursing home setting: A systematic review and meta-analysis.

Journal Article Health science reports · June 2023 Background and aimsFew studies have meta-analyzed different prognostic models developed for older adults, especially nursing home residents. We aimed to systematically review and meta-analyze the performance of all published models that predicted ... Full text Cite

Trends in global health research among universities in China: a bibliometric analysis.

Journal Article Glob Health Res Policy · April 6, 2023 BACKGROUND: There has been considerable progress in developing global health education and research in China. Nevertheless, evidence of the progress of Chinese universities' contributions to global health research is limited. More efforts are needed to dep ... Full text Link to item Cite

Association of Joint Genetic and Social Environmental Risks With Incident Myocardial Infarction: Results From the Health and Retirement Study.

Journal Article Journal of the American Heart Association · March 2023 Background Myocardial infarction (MI) is a significant clinical and public health problem worldwide. However, little research has assessed the interplay between genetic susceptibility and social environment in the development of MI. Methods and Results Dat ... Full text Cite

Projecting Long-Term Care Costs for Home and Community-Based Services in China from 2005 to 2050.

Journal Article Journal of the American Medical Directors Association · February 2023 ObjectivesThe aim of this study was to estimate and project the trend in long-term care (LTC) costs for home and community-based services as a percentage of gross domestic product in China between 2005 and 2050.DesignLongitudinal.Sett ... Full text Cite

Prediction models for depression risk among older adults: systematic review and critical appraisal.

Journal Article Ageing research reviews · January 2023 ObjectiveTo provide an overview of prediction models for the risk of major depressive disorder (MDD) among older adults.MethodsWe conducted a systematic review combined with a meta-analysis and critical appraisal of published studies on e ... Full text Open Access Cite

Association of dementia comorbidities with caregivers' physical, psychological, social, and financial burden.

Journal Article BMC geriatrics · January 2023 BackgroundInformal caregivers of older adults with dementia may experience substantial burdens during their caregiving process, especially when caring for older adults with other comorbid conditions. This study evaluated whether and how comorbidit ... Full text Cite

Disease burden of ageing, sex and regional disparities and health resources allocation: a longitudinal analysis of 31 provinces in Mainland China.

Journal Article BMJ Open · November 16, 2022 OBJECTIVES: To measure the disease burden of ageing based on age-related diseases (ARDs), the sex and regional disparities and the impact of health resources allocation on the burden in China. DESIGN: A national comparative study based on Global Burden of ... Full text Link to item Cite

Association of Retail Environment and Neighborhood Socioeconomic Status With Mortality Among Community-Dwelling Older Adults in the United States: Cardiovascular Health Study.

Journal Article The journals of gerontology. Series A, Biological sciences and medical sciences · November 2022 BackgroundFew studies have examined the association of neighborhood environment and mortality among community-dwelling older populations. Geographic Information Systems-based measures of neighborhood physical environment may provide new insights o ... Full text Cite

Association of multimorbidity patterns with incident disability and recovery of independence among middle-aged and older adults.

Journal Article Age and ageing · August 2022 Objectiveto identify multimorbidity patterns among middle-aged and older adults in China and examine how these patterns are associated with incident disability and recovery of independence.Methodsdata were from The China Health and Retire ... Full text Cite

Continue or not to continue? Attitudes towards deprescribing among community-dwelling older adults in China.

Journal Article BMC geriatrics · June 2022 BackgroundInappropriate prescribing of medications and polypharmacy among older adults are associated with a wide range of adverse outcomes. It is critical to understand the attitudes towards deprescribing-reducing the use of potentially inappropr ... Full text Cite

Association between indoor ventilation frequency and cognitive function among community-dwelling older adults in China: results from the Chinese longitudinal healthy longevity survey.

Journal Article BMC geriatrics · February 2022 BackgroundsEmerging evidence suggested that indoor air pollution caused long-term adverse effects on cognitive function among older adults who spend more than 85% of their time indoors. Although high indoor ventilation can mitigate the effect of i ... Full text Cite

Associations Between 20-Year Lipid Variability Throughout Young Adulthood and Midlife Cognitive Function and Brain Integrity.

Journal Article The journals of gerontology. Series A, Biological sciences and medical sciences · January 2022 BackgroundLittle is known about long-term lipid variability in young adulthood in relation to cognitive function and brain integrity in midlife.MethodWe studied 3 328 adults from the Coronary Artery Risk Development in Young Adults. We de ... Full text Cite

A Simplified Approach for Classifying Physical Resilience among Community-Dwelling Older Adults: The Health, Aging, and Body Composition Study.

Journal Article The Journal of frailty & aging · January 2022 BackgroundPhysical resilience is an emerging concept within the context of aging and geriatric medicine, and we previously developed and validated one such indicator based on the mismatch between persons' frailty level and multimorbidity burden. W ... Full text Cite

Association between early life circumstances and depressive symptoms among Chinese older adults: Results from China health and retirement longitudinal study: Early life circumstances and depression.

Journal Article Journal of affective disorders · September 2021 BackgroundA growing body of literature suggests that early life circumstances can influence mental health throughout the lifespan. However, how these early life circumstances cumulatively contribute to depression in old age is not completely under ... Full text Cite

Association between allostatic load and mortality among Chinese older adults: the Chinese Longitudinal Health and Longevity Study.

Journal Article BMJ open · August 2021 BackgroundAllostatic load (AL) has shown that high burden of AL is associated with increased risk of adverse outcomes, but little attention has been paid to China with largest ageing population in the world.ObjectiveThis study is to exami ... Full text Cite

Subclinical Vascular Disease Burden and Premature Mortality Among Middle-aged Adults: the Atherosclerosis Risk in Communities Study.

Journal Article Journal of general internal medicine · July 2021 BackgroundWhether high burden of subclinical vascular disease (SVD) is associated with increased premature mortality among middle-aged adults is not adequately understood. The association of midlife SVD burden with premature mortality among middle ... Full text Cite

Association between primary caregiver type and mortality among Chinese older adults with disability: a prospective cohort study.

Journal Article BMC geriatrics · April 2021 BackgroundSocio-demographic transitions have dramatically changed the traditional family care settings in China, caused unmet care needs among older adults. However, whether different primary caregiver types have different influences on disabled o ... Full text Cite

Level and Change in N-Terminal Pro-B-Type Natriuretic Peptide and Kidney Function and Survival to Age 90.

Journal Article The journals of gerontology. Series A, Biological sciences and medical sciences · February 2021 BackgroundMany traditional cardiovascular risk factors do not predict survival to very old age. Studies have shown associations of estimated glomerular filtration rate (eGFR) and N-terminal pro-B-type natriuretic peptide (NT-pro-BNP) with cardiova ... Full text Cite

A Coordinated Multi-study Analysis of the Longitudinal Association Between Handgrip Strength and Cognitive Function in Older Adults.

Journal Article The journals of gerontology. Series B, Psychological sciences and social sciences · January 2021 ObjectiveHandgrip strength, an indicator of overall muscle strength, has been found to be associated with slower rate of cognitive decline and decreased risk for cognitive impairment and dementia. However, evaluating the replicability of associati ... Full text Cite

A machine learning based aging measure among middle-aged and older Chinese adults: the China Health and Retirement Longitudinal Study

Journal Article · 2021 Background Biological age (BA) has been accepted as a more accurate proxy of aging than chronological age (CA). This study aimed to use machine learning (ML) algorithms to estimate BA in the Chinese population. Methods We used data from 9 ... Full text Cite

Machine Learning and Prediction of All-Cause Mortality among Chinese Older Adults

Journal Article · 2021 Background and aim Mortality risk stratification was vital for targeted intervention. This study aimed at building the prediction model of all-cause mortality among Chinese dwelling elderly with different methods including regression models and ma ... Full text Cite

A research agenda for ageing in China in the 21st century (2nd edition): Focusing on basic and translational research, long-term care, policy and social networks.

Journal Article Ageing research reviews · December 2020 One of the key issues facing public healthcare is the global trend of an increasingly ageing society which continues to present policy makers and caregivers with formidable healthcare and socio-economic challenges. Ageing is the primary contributor to a br ... Full text Cite

Prevalence and health correlates of reduced kidney function among community-dwelling Chinese older adults: the China Health and Retirement Longitudinal Study.

Journal Article BMJ open · December 2020 ObjectivesWe aimed to understand the prevalence of reduced kidney function in China by sociodemographics and geographical region, and to examine health correlates of reduced kidney function.DesignCross-sectional study.Setting and part ... Full text Cite

Prevalence and health correlates of anaemia among community-dwelling Chinese older adults: the China Health and Retirement Longitudinal Study.

Journal Article BMJ open · October 2020 ObjectivesTo identify the prevalence of anaemia among older adults in China by sociodemographic and geographical regions, and cross-sectionally examine the associations between anaemia and several geriatric outcomes.DesignCross-sectional ... Full text Cite

Quantifying and Classifying Physical Resilience Among Older Adults: The Health, Aging, and Body Composition Study.

Journal Article The journals of gerontology. Series A, Biological sciences and medical sciences · September 2020 BackgroundThe concept of resilience has gained increasing attention in aging research; however, current literature lacks consensus on how to measure resilience. We constructed a novel resilience measure based on the degree of mismatch between pers ... Full text Cite

Residential Greenness and Frailty Among Older Adults: A Longitudinal Cohort in China.

Journal Article Journal of the American Medical Directors Association · June 2020 ObjectivesFrailty is an accumulation of deficits characterized by reduced resilience to stressors and increased vulnerability to adverse outcomes. There is evolving evidence on the health benefits of residential greenness, but little is known abou ... Full text Cite

The Association between Frailty and Healthcare Expenditure among Chinese Older Adults.

Journal Article Journal of the American Medical Directors Association · June 2020 ObjectivesThe purpose of this study was to examine whether frailty could explain variability in healthcare expenditure beyond multimorbidity and disability among Chinese older adults.DesignCross-sectional.Setting and participants ... Full text Cite

Frailty as a predictor of all-cause mortality and readmission in older patients with acute coronary syndrome : A systematic review and meta-analysis.

Journal Article Wiener klinische Wochenschrift · June 2020 BackgroundEvidence from longitudinal studies linking frailty and outcome after acute coronary syndrome (ACS) is mixed. This systematic review and meta-analysis aimed to examine whether frailty is a predictor of all-cause mortality and hospital rea ... Full text Cite

Association of Frailty with recovery from disability among community-dwelling Chinese older adults: China health and retirement longitudinal study.

Journal Article BMC geriatrics · March 2020 BackgroundsLittle is known about the role of frailty in the recovery process of disability among older adults. We examined the association between frailty and recovery from activities of daily living (ADL) and instrumental ADL (IADL) disability am ... Full text Cite

The Association between Allostatic Load and Mortality among Chinese Older Adults: The Chinese Longitudinal Health and Longevity Study

Journal Article · 2020 Background: Allostatic load, as multiple biomarker measures of ‘wear and tear’ on physiological systems, has shown some promise that high burden of AL is associated with increased risk of adverse outcomes, but little attention has been paid to Ch ... Full text Cite

Sleep Duration and the Risk of Dementia: A Systematic Review and Meta-analysis of Prospective Cohort Studies.

Journal Article Journal of the American Medical Directors Association · December 2019 ObjectiveEpidemiologic studies have reported inconsistent findings about the association between sleep duration and the risk of dementia. We aimed to clarify this association by method of meta-analysis.DesignSystematic review and meta-ana ... Full text Cite

Incidence of frailty among community-dwelling older adults: a nationally representative profile in China.

Journal Article BMC geriatrics · December 2019 BackgroundFrailty is a clinically recognizable state of reduced resilience to stressors and increased vulnerability to adverse outcomes. The majority of studies have focused on the prevalence and risk factors of frailty, while the incidence of fra ... Full text Cite

Blood pressure management in older adults: A multiple-choice question?

Journal Article Journal of clinical hypertension (Greenwich, Conn.) · November 2019 Full text Cite

A Multi-study Coordinated Meta-analysis of Pulmonary Function and Cognition in Aging.

Journal Article The journals of gerontology. Series A, Biological sciences and medical sciences · October 2019 BackgroundSubstantial research is dedicated to understanding the aging-related dynamics among individual differences in level, change, and variation across physical and cognitive abilities. Evaluating replicability and synthesizing these findings ... Full text Cite

Commentary: Impact of new hypertension guideline among people living with HIV in Ghana.

Journal Article Journal of clinical hypertension (Greenwich, Conn.) · June 2019 Full text Cite

Association of Frailty With Recovery From Disability Among Community-Dwelling Older Adults: Results From Two Large U.S. Cohorts.

Journal Article The journals of gerontology. Series A, Biological sciences and medical sciences · March 2019 BackgroundDisability in activities of daily living (ADLs) is a dynamic process and transitions among different disability states are common. However, little is known about factors affecting recovery from disability. We examined the association bet ... Full text Cite

Development, Construct Validity, and Predictive Validity of a Continuous Frailty Scale: Results From 2 Large US Cohorts.

Journal Article American journal of epidemiology · August 2018 Frailty is an age-related clinical syndrome of decreased resilience to stressors. Among numerous assessments of frailty, the frailty phenotype (FP) scale proposed by Fried et al. has been the most widely used. We aimed to develop a continuous frailty scale ... Full text Cite

Index of Healthy Aging in Chinese Older Adults: China Health and Retirement Longitudinal Study.

Journal Article Journal of the American Geriatrics Society · July 2018 ObjectivesTo characterize the distribution of an index of healthy aging-the Chinese Healthy Aging Index (CHAI)-in Chinese adults aged 60 and older according to sociodemographic characteristics and geographic region and to examine the association b ... Full text Cite

The association of neighborhood context with health outcomes among ethnic minority breast cancer survivors.

Journal Article Journal of behavioral medicine · February 2018 While individual-level determinants of health, such as education and income, have been well documented among breast cancer survivors, little is known about the role of neighborhood context on survivorship outcomes among this population. The present study e ... Full text Open Access Cite

Reply to: Systolic Blood Pressure and Mortality: Role of Reverse Causation.

Journal Article Journal of the American Geriatrics Society · January 2018 Full text Cite

Prevalence and Correlates of Frailty Among Community-Dwelling Chinese Older Adults: The China Health and Retirement Longitudinal Study.

Journal Article The journals of gerontology. Series A, Biological sciences and medical sciences · December 2017 BackgroundFrailty is an age-related clinical syndrome of decreased resilience to stressors and is associated with numerous adverse outcomes. Although there is preponderance of literature on frailty in developed countries, limited investigations ha ... Full text Open Access Cite

A Modified Healthy Aging Index and Its Association with Mortality: The National Health and Nutrition Examination Survey, 1999-2002.

Journal Article The journals of gerontology. Series A, Biological sciences and medical sciences · October 2017 BackgroundComorbidity indices that are based on clinically recognized disease do not capture the full spectrum of health. The Healthy Aging Index (HAI) was recently developed to describe a wider range of health and disease across multiple organ sy ... Full text Open Access Cite

Functional Status Modifies the Association of Blood Pressure with Death in Elders: Health and Retirement Study.

Journal Article Journal of the American Geriatrics Society · July 2017 ObjectiveTo examine whether grip strength, gait speed, and the combination of the two physical functioning measures modified the association of systolic BP (SBP) and diastolic BP (DBP) with mortality.DesignNationally representative cohort ... Full text Open Access Cite

Visit-to-Visit Blood Pressure Variability and Mortality and Cardiovascular Outcomes Among Older Adults: The Health, Aging, and Body Composition Study.

Journal Article American journal of hypertension · February 2017 BackgroundLevel of blood pressure (BP) is strongly associated with cardiovascular (CV) events and mortality. However, it is questionable whether mean BP can fully capture BP-related vascular risk. Increasing attention has been given to the value o ... Full text Open Access Cite

Blood Pressure Trajectory, Gait Speed, and Outcomes: The Health, Aging, and Body Composition Study.

Journal Article The journals of gerontology. Series A, Biological sciences and medical sciences · December 2016 BackgroundThe present study aimed to (i) evaluate previous observations that the association of blood pressure (BP) with outcomes varies by gait speed and (ii) evaluate the association of subsequent changes in BP and cardiovascular risk.Method ... Full text Open Access Cite

Association of retirement age with mortality: a population-based longitudinal study among older adults in the USA.

Journal Article Journal of epidemiology and community health · September 2016 BackgroundRetirement is an important transitional process in later life. Despite a large body of research examining the impacts of health on retirement, questions still remain regarding the association of retirement age with survival. We aimed to ... Full text Open Access Cite