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Rathan Markandan Subramaniam

Adjunct Professor in the Department of Radiology
Radiology

Selected Publications


ACR-ACNM-ARS-ASTRO-SNMMI Practice Parameter for the Performance of Therapy With Radiopharmaceuticals.

Journal Article Am J Clin Oncol · April 1, 2024 OBJECTIVES: This practice parameter was revised collaboratively by the American College of Radiology (ACR), the American College of Nuclear Medicine, the American Radium Society, the American Society for Radiation Oncology, and the Society of Nuclear Medic ... Full text Link to item Cite

Quarter-Century PET/Computed Tomography Transformation of Oncology: Hepatobiliary and Pancreatic Cancer.

Journal Article PET Clin · April 2024 [18F] Fluorodeoxyglucose (18F-FDG) PET/CT can improve the staging accuracy and clinical management of patients with hepatobiliary and pancreatic cancers, by detection of unsuspected metastases. 18F-FDG PET/CT metabolic parameters are valuable in predicting ... Full text Link to item Cite

Quarter Century PET/Computed Tomography Transformation of Oncology: Neuroendocrine Tumors.

Journal Article PET Clin · April 2024 Significant improvement in molecular imaging and theranostics in the management of neuroendocrine tumors (NETs) has been made in the last few decades. Somatostatin receptor-targeted PET imaging outperforms conventional, planar, and single-photon emission c ... Full text Link to item Cite

Role of PET/Computed Tomography in Gastric and Colorectal Malignancies.

Journal Article PET Clin · April 2024 This article focuses on the role of PET/computed tomography in evaluating and managing gastric cancer and colorectal cancer. The authors start with describing the common aspects of imaging with 2-deoxy-2-18F-d-glucose, followed by tumor-specific discussion ... Full text Link to item Cite

Quarter Century Positron Emission Tomography/Computed Tomography Transformation of Oncology: Head and Neck Cancer.

Journal Article PET Clin · April 2024 During the last 2 decades, f-18 fluorodeoxyglucose positron emission tomography/computed tomography (18F FDG PET/CT) has transformed the clinical head and neck cancer imaging for patient management and predicting survival outcomes. It is now widely used fo ... Full text Link to item Cite

Quarter-Century PET/CT Transformation of Oncology: Lymphoma.

Journal Article PET Clin · April 2024 The clinical landscape of lymphomas has changed dramatically over the last 2 decades, including significant progress made in the understanding and utilization of imaging modalities and the available treatment options for both indolent and aggressive lympho ... Full text Link to item Cite

Quality of life following surgery for head and neck cancer: Evidence from ACRIN 6685.

Journal Article Head Neck · February 14, 2024 BACKGROUND: This study examined the trajectory of health-related quality of life (HRQoL) for patients with clinical stage N0 HNSCC enrolled in ACRIN 6685 who underwent elective neck dissection(s). METHODS: HRQoL of 230 patients in the ACRIN 6685 trial was ... Full text Link to item Cite

Genetic and epigenetic features of neuroendocrine prostate cancer and their emerging applications.

Chapter · 2024 Prostate cancer is the second most prevalent cancer in men globally. De novo neuroendocrine prostate cancer (NEPC) is uncommon at initial diagnosis, however, (treatment-induced) t-NEPC emerges in up to 25% of prostate adenocarcinoma (PRAD) cases treated wi ... Full text Link to item Cite

ACR Appropriateness Criteria® Staging and Post-Therapy Assessment of Head and Neck Cancer.

Journal Article J Am Coll Radiol · November 2023 Imaging of head and neck cancer at initial staging and as part of post-treatment surveillance is a key component of patient care as it guides treatment strategy and aids determination of prognosis. Head and neck cancer includes a heterogenous group of mali ... Full text Link to item Cite

Evaluation of the Diagnostic Accuracy of FAPI PET/CT in Oncologic Studies: Systematic Review and Metaanalysis.

Journal Article J Nucl Med · August 2023 Fibroblast-activation protein is a promising target for oncologic molecular imaging. Studies show that fibroblast activation protein inhibitor (FAPI) radiotracers are accurate diagnostics with favorable tumor-to-background ratios across various cancers. Th ... Full text Link to item Cite

Screening for extranodal extension in HPV-associated oropharyngeal carcinoma: evaluation of a CT-based deep learning algorithm in patient data from a multicentre, randomised de-escalation trial.

Journal Article Lancet Digit Health · June 2023 BACKGROUND: Pretreatment identification of pathological extranodal extension (ENE) would guide therapy de-escalation strategies for in human papillomavirus (HPV)-associated oropharyngeal carcinoma but is diagnostically challenging. ECOG-ACRIN Cancer Resear ... Full text Link to item Cite

Utility of pre-treatment 18 F-fluorodeoxyglucose PET radiomic analysis in assessing nodal involvement in cervical cancer.

Journal Article Nucl Med Commun · May 1, 2023 OBJECTIVE: Intratumor heterogeneity has prognostic value in cervical cancer, which can be depicted on 18 F-fluorodeoxyglucose ( 18 F-FDG) PET/computed tomography (PET/CT) and then quantitatively characterized by texture features. This study aimed to evalua ... Full text Link to item Cite

Student and Educator Experiences of an Integrated Medical Imaging Curriculum.

Journal Article Acad Radiol · April 2023 INTRODUCTION: Medical imaging is integrated across all years in the medical programs at the Medical School, in our country. Little is known about this pedagogical approach from the perspective of those who participate in it. This study investigated how stu ... Full text Link to item Cite

Diagnosis and Treatment of Lung Neuroendocrine Neoplasms: Somatostatin Receptor PET Imaging and Peptide Receptor Radionuclide Therapy.

Journal Article PET Clin · April 2023 Recently, advancement of somatostatin receptor (SSTR) imaging and theragnostic approach using peptide receptor radionuclide therapy (PRRT) have changed the paradigm of diagnosis and management of neuroendocrine tumor. 68Ga-DOTATATE PET/CT can diagnose the ... Full text Link to item Cite

Gastroenteropancreatic Neuroendocrine Tumor Diagnosis: DOTATATE PET/CT.

Journal Article PET Clin · April 2023 Gastroenteropancreatic neuroendocrine tumors(NETs), which arise from the small intestine, rectum, colon, appendix, or pancreas, have variable malignant potential with clinical behavior determined by proliferative activity according to the Ki-67 index and t ... Full text Link to item Cite

Paragangliomas and Pheochromocytomas: Positron Emission Tomography/Computed Tomography Diagnosis and Therapy.

Journal Article PET Clin · April 2023 Molecular imaging evaluation of pheochromocytomas and paragangliomas depends on multiple factors, such as localized versus metastatic disease, the genetic, and biochemical profile of tumors. Positron emission tomography/computed tomography (PET/CT) imaging ... Full text Link to item Cite

Neuroendocrine Neoplasms: Epidemiology, Diagnosis, and Management.

Journal Article PET Clin · April 2023 Neuroendocrine tumors have variety of biological and clinical characteristics. The classification of neuroendocrine neoplasm has evolved, and the newest 2019 World Health Organization classification outlines a well-differentiated high-grade G3 subtype, rec ... Full text Link to item Cite

Neuroendocrine Neoplasms: Genetics and Epigenetics.

Journal Article PET Clin · April 2023 Neuroendocrine neoplasms (NENs) are a group of rare, heterogeneous tumors of neuroendocrine cell origin, affecting a range of different organs. The clinical management of NENs poses significant challenges, as tumors are often diagnosed at an advanced stage ... Full text Link to item Cite

Gastro-Enteric-Pancreatic Neuroendocrine Tumor Treatment: 177Lu-DOTATATE.

Journal Article PET Clin · April 2023 177Lu-DOTA-TATE therapy is a highly effective therapy in metastatic, well-differentiated, somatostatin receptor-positive GEP-neuroendocrine tumors (NETs) with mostly tolerable adverse effects. Guidelines generally refer to peptide receptor radionuclide the ... Full text Link to item Cite

ACR-ACNM-ARS-ASTRO-SNMMI Practice Parameter for the Performance of Therapy With Radiopharmaceuticals.

Journal Article Am J Clin Oncol · April 1, 2024 OBJECTIVES: This practice parameter was revised collaboratively by the American College of Radiology (ACR), the American College of Nuclear Medicine, the American Radium Society, the American Society for Radiation Oncology, and the Society of Nuclear Medic ... Full text Link to item Cite

Quarter-Century PET/Computed Tomography Transformation of Oncology: Hepatobiliary and Pancreatic Cancer.

Journal Article PET Clin · April 2024 [18F] Fluorodeoxyglucose (18F-FDG) PET/CT can improve the staging accuracy and clinical management of patients with hepatobiliary and pancreatic cancers, by detection of unsuspected metastases. 18F-FDG PET/CT metabolic parameters are valuable in predicting ... Full text Link to item Cite

Quarter Century PET/Computed Tomography Transformation of Oncology: Neuroendocrine Tumors.

Journal Article PET Clin · April 2024 Significant improvement in molecular imaging and theranostics in the management of neuroendocrine tumors (NETs) has been made in the last few decades. Somatostatin receptor-targeted PET imaging outperforms conventional, planar, and single-photon emission c ... Full text Link to item Cite

Role of PET/Computed Tomography in Gastric and Colorectal Malignancies.

Journal Article PET Clin · April 2024 This article focuses on the role of PET/computed tomography in evaluating and managing gastric cancer and colorectal cancer. The authors start with describing the common aspects of imaging with 2-deoxy-2-18F-d-glucose, followed by tumor-specific discussion ... Full text Link to item Cite

Quarter Century Positron Emission Tomography/Computed Tomography Transformation of Oncology: Head and Neck Cancer.

Journal Article PET Clin · April 2024 During the last 2 decades, f-18 fluorodeoxyglucose positron emission tomography/computed tomography (18F FDG PET/CT) has transformed the clinical head and neck cancer imaging for patient management and predicting survival outcomes. It is now widely used fo ... Full text Link to item Cite

Quarter-Century PET/CT Transformation of Oncology: Lymphoma.

Journal Article PET Clin · April 2024 The clinical landscape of lymphomas has changed dramatically over the last 2 decades, including significant progress made in the understanding and utilization of imaging modalities and the available treatment options for both indolent and aggressive lympho ... Full text Link to item Cite

Quality of life following surgery for head and neck cancer: Evidence from ACRIN 6685.

Journal Article Head Neck · February 14, 2024 BACKGROUND: This study examined the trajectory of health-related quality of life (HRQoL) for patients with clinical stage N0 HNSCC enrolled in ACRIN 6685 who underwent elective neck dissection(s). METHODS: HRQoL of 230 patients in the ACRIN 6685 trial was ... Full text Link to item Cite

Genetic and epigenetic features of neuroendocrine prostate cancer and their emerging applications.

Chapter · 2024 Prostate cancer is the second most prevalent cancer in men globally. De novo neuroendocrine prostate cancer (NEPC) is uncommon at initial diagnosis, however, (treatment-induced) t-NEPC emerges in up to 25% of prostate adenocarcinoma (PRAD) cases treated wi ... Full text Link to item Cite

ACR Appropriateness Criteria® Staging and Post-Therapy Assessment of Head and Neck Cancer.

Journal Article J Am Coll Radiol · November 2023 Imaging of head and neck cancer at initial staging and as part of post-treatment surveillance is a key component of patient care as it guides treatment strategy and aids determination of prognosis. Head and neck cancer includes a heterogenous group of mali ... Full text Link to item Cite

Evaluation of the Diagnostic Accuracy of FAPI PET/CT in Oncologic Studies: Systematic Review and Metaanalysis.

Journal Article J Nucl Med · August 2023 Fibroblast-activation protein is a promising target for oncologic molecular imaging. Studies show that fibroblast activation protein inhibitor (FAPI) radiotracers are accurate diagnostics with favorable tumor-to-background ratios across various cancers. Th ... Full text Link to item Cite

Screening for extranodal extension in HPV-associated oropharyngeal carcinoma: evaluation of a CT-based deep learning algorithm in patient data from a multicentre, randomised de-escalation trial.

Journal Article Lancet Digit Health · June 2023 BACKGROUND: Pretreatment identification of pathological extranodal extension (ENE) would guide therapy de-escalation strategies for in human papillomavirus (HPV)-associated oropharyngeal carcinoma but is diagnostically challenging. ECOG-ACRIN Cancer Resear ... Full text Link to item Cite

Utility of pre-treatment 18 F-fluorodeoxyglucose PET radiomic analysis in assessing nodal involvement in cervical cancer.

Journal Article Nucl Med Commun · May 1, 2023 OBJECTIVE: Intratumor heterogeneity has prognostic value in cervical cancer, which can be depicted on 18 F-fluorodeoxyglucose ( 18 F-FDG) PET/computed tomography (PET/CT) and then quantitatively characterized by texture features. This study aimed to evalua ... Full text Link to item Cite

Student and Educator Experiences of an Integrated Medical Imaging Curriculum.

Journal Article Acad Radiol · April 2023 INTRODUCTION: Medical imaging is integrated across all years in the medical programs at the Medical School, in our country. Little is known about this pedagogical approach from the perspective of those who participate in it. This study investigated how stu ... Full text Link to item Cite

Diagnosis and Treatment of Lung Neuroendocrine Neoplasms: Somatostatin Receptor PET Imaging and Peptide Receptor Radionuclide Therapy.

Journal Article PET Clin · April 2023 Recently, advancement of somatostatin receptor (SSTR) imaging and theragnostic approach using peptide receptor radionuclide therapy (PRRT) have changed the paradigm of diagnosis and management of neuroendocrine tumor. 68Ga-DOTATATE PET/CT can diagnose the ... Full text Link to item Cite

Gastroenteropancreatic Neuroendocrine Tumor Diagnosis: DOTATATE PET/CT.

Journal Article PET Clin · April 2023 Gastroenteropancreatic neuroendocrine tumors(NETs), which arise from the small intestine, rectum, colon, appendix, or pancreas, have variable malignant potential with clinical behavior determined by proliferative activity according to the Ki-67 index and t ... Full text Link to item Cite

Paragangliomas and Pheochromocytomas: Positron Emission Tomography/Computed Tomography Diagnosis and Therapy.

Journal Article PET Clin · April 2023 Molecular imaging evaluation of pheochromocytomas and paragangliomas depends on multiple factors, such as localized versus metastatic disease, the genetic, and biochemical profile of tumors. Positron emission tomography/computed tomography (PET/CT) imaging ... Full text Link to item Cite

Neuroendocrine Neoplasms: Epidemiology, Diagnosis, and Management.

Journal Article PET Clin · April 2023 Neuroendocrine tumors have variety of biological and clinical characteristics. The classification of neuroendocrine neoplasm has evolved, and the newest 2019 World Health Organization classification outlines a well-differentiated high-grade G3 subtype, rec ... Full text Link to item Cite

Neuroendocrine Neoplasms: Genetics and Epigenetics.

Journal Article PET Clin · April 2023 Neuroendocrine neoplasms (NENs) are a group of rare, heterogeneous tumors of neuroendocrine cell origin, affecting a range of different organs. The clinical management of NENs poses significant challenges, as tumors are often diagnosed at an advanced stage ... Full text Link to item Cite

Gastro-Enteric-Pancreatic Neuroendocrine Tumor Treatment: 177Lu-DOTATATE.

Journal Article PET Clin · April 2023 177Lu-DOTA-TATE therapy is a highly effective therapy in metastatic, well-differentiated, somatostatin receptor-positive GEP-neuroendocrine tumors (NETs) with mostly tolerable adverse effects. Guidelines generally refer to peptide receptor radionuclide the ... Full text Link to item Cite

18F-FDG PET/CT Prediction of Treatment Outcomes in Human Papillomavirus-Positive, Locally Advanced Oropharyngeal Cancer Patients Receiving Deintensified Therapy: Results from NRG-HN002.

Journal Article J Nucl Med · March 2023 The purpose of this study was to determine the negative predictive value (NPV) of a 12- to 14-wk posttreatment PET/CT for 2-y progression-free survival (PFS) and locoregional control (LRC) in patients with p16-positive locoregionally advanced oropharyngeal ... Full text Link to item Cite

Asian migrants navigating New Zealand primary care: a qualitative study.

Journal Article J Prim Health Care · March 2023 Introduction Information on the responsiveness of the New Zealand (NZ) health system to Asians to enable navigation of healthcare services is currently lacking. Barriers experienced by Asian patients to enable optimal navigation of, and engagement with, he ... Full text Link to item Cite

Immunotherapy and Biomarker Testing in Recurrent and Metastatic Head and Neck Cancers: ASCO Guideline.

Journal Article Journal of clinical oncology : official journal of the American Society of Clinical Oncology · February 2023 PurposeTo provide evidence-based recommendations for practicing physicians and other health care providers on immunotherapy and biomarker testing for head and neck cancers.MethodsASCO convened an Expert Panel of medical oncology, surgical ... Full text Cite

Impact of Neck PET/CT Positivity on Survival Outcomes-Visual and Quantitative Assessment: Results From ACRIN 6685.

Journal Article Clin Nucl Med · February 1, 2023 INTRODUCTION: FDG PET/CT was prospectively studied in 287 cN0 head and neck cancer patients in ACRIN 6685, and additional analysis of neck FDG uptake upon recurrence-free survival (RFS) and overall survival (OS) was performed. PATIENTS AND METHODS: Two hun ... Full text Link to item Cite

Clinical practice in prostate PET imaging.

Journal Article Ther Adv Med Oncol · 2023 Positron emission tomography (PET) imaging in prostate cancer has advanced significantly in the past decade with prostate cancer targeted radiopharmaceuticals now playing a growing role in diagnosis, staging, and treatment. This narrative review focuses on ... Full text Link to item Cite

18F-FDG PET/CT Staging of Head and Neck Cancer: Interobserver Agreement and Accuracy-Results from Multicenter ACRIN 6685 Clinical Trial.

Journal Article J Nucl Med · December 2022 To our knowledge, no prior multicenter clinical trial has reported interobserver agreement of 18F-FDG PET/CT scans for staging of clinical N0 neck in head and neck cancer. Methods: A total of 287 participants were recruited. For visual analysis, positive n ... Full text Link to item Cite

FDG PET/CT for Primary Staging of Lung Cancer and Mesothelioma.

Journal Article Semin Nucl Med · November 2022 Lung cancer is the leading cause of cancer-related mortality in the United States. Accurate staging at initial diagnosis determines appropriate treatment and is the most important predictor of survival. Since 2018, the 8th edition of the TNM staging system ... Full text Link to item Cite

PET Imaging of Dementia: Update 2022.

Journal Article Clin Nucl Med · September 1, 2022 PET imaging plays an essential role in achieving earlier and more specific diagnoses of dementia syndromes, important for clinical prognostication and optimal medical management. This has become especially vital with the recent development of pathology-spe ... Full text Link to item Cite

ACR-ACNM-ASTRO-SNMMI Practice Parameter for Lutetium-177 (Lu-177) DOTATATE Therapy.

Journal Article Clin Nucl Med · June 1, 2022 OBJECTIVES: This practice parameter (PP) for Lutetium-177 (Lu-177) DOTATATE peptide receptor radionuclide therapy (PRRT) aims to guide authorized users in selection of appropriate adult candidates with gastroeneropancreatic neuroendocrine tumors (GEP-NETs) ... Full text Link to item Cite

ACR-ACNM-ASTRO-SNMMI Practice Parameter for Lutetium-177 (Lu-177) DOTATATE Therapy.

Journal Article Am J Clin Oncol · June 1, 2022 OBJECTIVES: This practice parameter (PP) for Lutetium-177 (Lu-177) DOTATATE peptide receptor radionuclide therapy (PRRT) aims to guide authorized users in selection of appropriate adult candidates with gastroeneropancreatic neuroendocrine tumors (GEP-NETs) ... Full text Link to item Cite

ACR Appropriateness Criteria® Sinonasal Disease: 2021 Update.

Journal Article J Am Coll Radiol · May 2022 This article presents guidelines for initial imaging utilization in patients presenting with sinonasal disease, including acute rhinosinusitis without and with suspected orbital and intracranial complications, chronic rhinosinusitis, suspected invasive fun ... Full text Link to item Cite

PET/Computed Tomography: Post-therapy Follow-up in Head and Neck Cancer.

Journal Article PET Clin · April 2022 PET/computed tomography (CT) is a valuable tool in post-therapy follow-up of head and neck cancers. PET/CT is sensitive and specific, can detect recurrences that otherwise may be missed on routine clinical examination or conventional imaging, and also can ... Full text Link to item Cite

2-Deoxy-2-[18F] Fluoro-d-Glucose PET/Computed Tomography: Therapy Response Assessment in Head and Neck Cancer.

Journal Article PET Clin · April 2022 18F-FDG-PET/CT (2-deoxy-2-[18F] fluoro-d-glucose PET/computed tomography) is a reliable modality for accurate assessment of treatment response, early detection of recurrence, or second primary tumors in head and neck squamous cell carcinoma (HNSCC), if per ... Full text Link to item Cite

PET/Computed Tomography: Laryngeal and Hypopharyngeal Cancers.

Journal Article PET Clin · April 2022 Treatment of laryngeal and hypopharyngeal tumors with surgery, radiation therapy, and chemotherapy is aimed at improving survival and preserving function. PET with fluorodeoxyglucose F 18 (18F FDG-PET)/computed tomography is the standard of care and an int ... Full text Link to item Cite

PET Imaging of Oral Cavity and Oropharyngeal Cancers.

Journal Article PET Clin · April 2022 Fluorine-18 fluorodeoxyglucose PET/computed tomography (18F-FDG PET/CT) plays an important role in the staging, treatment planning, treatment response assessment, detecting recurrent disease, and predicting prognosis in patients with oral cavity and oropha ... Full text Link to item Cite

The responsibilities of medical students in providing advice on the COVID-19 vaccination programme.

Journal Article N Z Med J · April 1, 2022 The COVID-19 global pandemic has highlighted the potential roles and responsibilities of medical students in healthcare systems. Senior clinical students may be able to contribute practically, but all medical students, regardless of their level of training ... Link to item Cite

Performance characteristics of 18F-fluciclovine positron emission tomography/computed tomography prior to retroperitoneal lymph node dissection.

Journal Article Can Urol Assoc J · March 2022 INTRODUCTION: We aimed to determine whether anti-1-amino-3-18F-fluorocyclobutane-1-carboxylic acid (18F-fluciclovine) positron emission tomography/computed tomography (PET/CT) can accurately detect residual non-seminomatous germ cell tumor (NSGCT) prior to ... Full text Link to item Cite

Hidden figures and misnomers: a case for disaggregated Asian health statistics in Aotearoa New Zealand to improve health outcomes.

Journal Article N Z Med J · November 26, 2021 People of Asian ethnicity in Aotearoa New Zealand currently constitute 15% of the population. The majority are migrants. The current sources of data to monitor Asian health in New Zealand are routine population surveys and administrative data. This article ... Link to item Cite

ACR Appropriateness Criteria® Parathyroid Adenoma.

Journal Article J Am Coll Radiol · November 2021 Hyperparathyroidism is defined as excessive parathyroid hormone production. The diagnosis is made through biochemical testing, in which imaging has no role. However, imaging is appropriate for preoperative parathyroid gland localization with the intent of ... Full text Link to item Cite

PET Imaging for Head and Neck Cancers.

Journal Article Radiol Clin North Am · September 2021 Head and neck cancers are commonly encountered cancers in clinical practice in the United States. Fluorine-18-fluorodeoxyglucose (18F-FDG) PET/CT has been clinically applied in staging, occult primary tumor detection, treatment planning, response assessmen ... Full text Link to item Cite

Academic Leadership: Harnessing the Culture of Inclusion in Nuclear Medicine and Radiology.

Journal Article Clin Nucl Med · August 1, 2021 Culture of inclusion is of utmost need in today's practice of radiology and nuclear medicine. This article briefly describes the importance of establishing and enriching the culture of embracing different talents, perspectives, and expertise with considera ... Full text Link to item Cite

18F-fluciclovine PET/CT detection of biochemical recurrent prostate cancer in patients with PSA levels <2.00 ng/mL.

Journal Article Nucl Med Commun · August 1, 2021 OBJECTIVE: To establish the detection rate of prostate cancer recurrence following definitive therapy by 18F-fluciclovine PET/computed tomography (CT) in patients with biochemical recurrence (BCR) and prostate-specific antigen (PSA) levels less than 2.00 n ... Full text Link to item Cite

FDG-PET/CT and Pathology in Newly Diagnosed Head and Neck Cancer: ACRIN 6685 Trial, FDG-PET/CT cN0.

Journal Article Otolaryngol Head Neck Surg · June 2021 OBJECTIVE: FDG-PET/CT (fluorodeoxyglucose-positron emission tomography/computed tomography) is effective to assess for occult neck nodal disease. We report risks and patterns of nodal disease based on primary site and nodal level from data on the dissected ... Full text Link to item Cite

177Lu-PSMA Therapy in Metastatic Castration-Resistant Prostate Cancer.

Journal Article Biomedicines · April 15, 2021 The aim of this narrative review is to evaluate the current status of 177Lu-PSMA (prostate specific membrane antigen) therapy for metastatic castration-resistant prostate cancer (mCRPC) in the light of the current literature. We also addressed patient prep ... Full text Link to item Cite

Role of 18F-Fluciclovine and Prostate-Specific Membrane Antigen PET/CT in Guiding Management of Oligometastatic Prostate Cancer: AJR Expert Panel Narrative Review.

Journal Article AJR Am J Roentgenol · April 2021 Twenty-five years ago, oligometastatic disease was proposed as an intermediary clinical state of cancer with unique implications for therapies that may impact cancer evolution and patient outcome. Identification of limited metastases that are potentially a ... Full text Link to item Cite

Predicting Parkinson's disease trajectory using clinical and neuroimaging baseline measures.

Journal Article Parkinsonism Relat Disord · April 2021 INTRODUCTION: Predictive biomarkers of Parkinson's Disease progression are needed to expedite neuroprotective treatment development and facilitate prognoses for patients. This work uses measures derived from resting-state functional magnetic resonance imag ... Full text Link to item Cite

Reduced-Dose Radiation Therapy for HPV-Associated Oropharyngeal Carcinoma (NRG Oncology HN002).

Journal Article J Clin Oncol · March 20, 2021 PURPOSE: Reducing radiation treatment dose could improve the quality of life (QOL) of patients with good-risk human papillomavirus-associated oropharyngeal squamous cell carcinoma (OPSCC). Whether reduced-dose radiation produces disease control and QOL equ ... Full text Link to item Cite

Prospective Phase 2 Study of Radiation Therapy Dose and Volume De-escalation for Elective Neck Treatment of Oropharyngeal and Laryngeal Cancer.

Conference Int J Radiat Oncol Biol Phys · March 15, 2021 PURPOSE: The required elective nodal dose and volumes for head and neck intensity modulated radiation therapy have largely been extrapolated from conventional radiation therapy fields. In this prospective, dual-center, phase 2 study, we investigated the ef ... Full text Link to item Cite

Role of Non-FDG-PET/CT in Head and Neck Cancer.

Journal Article Semin Nucl Med · January 2021 Head and neck cancers are commonly encountered malignancies in the United States, of which the majority are attributed to squamous cell carcinoma. 18F-FDG-PET/CT has been well established in the evaluation, treatment planning, prognostic implications of th ... Full text Link to item Cite

Fibroblast-Activated Protein Inhibitor PET/CT: Cancer Diagnosis and Management.

Journal Article Front Oncol · 2021 Fibroblast activation protein (FAP), overexpressed on cancer-associated fibroblasts (CAFs), is a novel target for molecular imaging of various tumors. Recently, the development of several small-molecule FAP inhibitors for radiolabeling with 68Ga has result ... Full text Link to item Cite

Intratumoral Metabolic Heterogeneity and Other Quantitative 18F-FDG PET/CT Parameters for Prognosis Prediction in Esophageal Cancer.

Journal Article Radiol Imaging Cancer · January 2021 PURPOSE: To evaluate the impact of intratumoral metabolic heterogeneity (IMH) and other quantitative fluorine 18 (18F) fluorodeoxyglucose (FDG) PET/CT parameters for predicting progression-free survival (PFS) and overall survival (OS) in patients with esop ... Full text Link to item Cite

Ga-68 DOTATATE PET/CT and F-18 FDG PET/CT in the evaluation of low and intermediate versus high-grade neuroendocrine tumors.

Journal Article Nucl Med Commun · October 2020 OBJECTIVE: We investigated the role of Ga-68 DOTATATE PET/CT in comparison to F-18 FDG PET/CT in patients with low and intermediate versus high-grade neuroendocrine tumors (NETs). METHODS: We identified 81 patients who underwent Ga-68 DOTATATE PET/CT at ou ... Full text Link to item Cite

Fluorine-18-Labeled Fluciclovine PET/CT in Primary and Biochemical Recurrent Prostate Cancer Management.

Journal Article AJR Am J Roentgenol · August 2020 OBJECTIVE. The purpose of this article is to review the utility of 18F-fluciclovine PET/CT in the evaluation of recurrent prostate cancer. CONCLUSION. Fluorine-18-labeled fluciclovine PET/CT has shown promise in the evaluation of recurrent prostate cancer. ... Full text Link to item Cite

ACR-ACNM-ASTRO-SNMMI Practice Parameter for the Performance of Therapy With Radium-223.

Journal Article Am J Clin Oncol · August 2020 AIM/OBJECTIVES/BACKGROUND: The goal of therapy with unsealed radiopharmaceutical sources is to provide either cure or significant prolongation of disease-specific survival, and effective reduction and/or prevention of adverse disease-related symptoms or un ... Full text Link to item Cite

ACR Appropriateness Criteria® Dementia.

Journal Article J Am Coll Radiol · May 2020 Degenerative disease of the central nervous system is a growing public health concern. The primary role of neuroimaging in the workup of patients with probable or possible Alzheimer disease has typically been to exclude other significant intracranial abnor ... Full text Link to item Cite

ACR Appropriateness Criteria® Movement Disorders and Neurodegenerative Diseases.

Journal Article J Am Coll Radiol · May 2020 Movement disorders and neurodegenerative diseases are a variety of conditions that involve progressive neuronal degeneration, injury, or death. Establishing the correct diagnosis of a movement disorder or neurodegenerative process can be difficult due to t ... Full text Link to item Cite

Value of Intratumoral Metabolic Heterogeneity and Quantitative 18F-FDG PET/CT Parameters in Predicting Prognosis for Patients With Cervical Cancer.

Journal Article AJR Am J Roentgenol · April 2020 OBJECTIVE. The purpose of this study is to evaluate the prognostic value of quantitative metabolic parameters from pretreatment PET/CT scans of patients with squamous cell cervical cancer. MATERIALS AND METHODS. This retrospective study included 120 patien ... Full text Link to item Cite

The QIBA Profile for FDG PET/CT as an Imaging Biomarker Measuring Response to Cancer Therapy.

Journal Article Radiology · March 2020 The Quantitative Imaging Biomarkers Alliance (QIBA) Profile for fluorodeoxyglucose (FDG) PET/CT imaging was created by QIBA to both characterize and reduce the variability of standardized uptake values (SUVs). The Profile provides two complementary claims ... Full text Open Access Link to item Cite

Clinical and Technical Considerations for Brain PET Imaging for Dementia.

Journal Article J Nucl Med Technol · March 2020 The number of cases of dementia has dramatically increased over the last decade. Imaging of the brain with PET has been used for many years, but in the past decade the radiopharmaceuticals and technology available for imaging dementia have vastly improved. ... Full text Link to item Cite

Molecular and Functional Imaging in Oncology Therapy Response

Chapter · January 1, 2020 Molecular and functional imaging aims to assess oncologic therapy response by integrating molecular and functional tumor biology in order to assess therapeutic efficacy and improve patient outcome. Most oncologic processes reflect heterogeneous disease bot ... Full text Cite

ACR Appropriateness Criteria® Headache.

Journal Article J Am Coll Radiol · November 2019 Headache is one of the most common human afflictions. In most cases, headaches are benign and idiopathic, and resolve spontaneously or with minor therapeutic measures. Imaging is not required for many types of headaches. However, patients presenting with h ... Full text Link to item Cite

Lung Cancer Recurrence: 18F-FDG PET/CT in Clinical Practice.

Journal Article AJR Am J Roentgenol · November 2019 OBJECTIVE: The purpose of this article is to summarize the clinical utility of 18F-FDG PET/CT in the evaluation of lung cancer recurrence with an emphasis on typical anatomic and metabolic patterns of recurrence, expected posttherapeutic changes, and commo ... Full text Link to item Cite

Impact of Point-Spread Function Reconstruction on 68Ga-DOTATATE PET/CT Quantitative Imaging Parameters.

Conference AJR Am J Roentgenol · September 2019 OBJECTIVE. The objective of our study was to investigate the impact of point-spread function (PSF) reconstruction and lesion size on 68Ga-tetraazacyclododecanetetraacetic acid-DPhe1-Tyr3-octreotate (DOTATATE) PET/CT quantitative parameters. MATERIALS AND M ... Full text Link to item Cite

Therapy With 177Lu-DOTATATE: Clinical Implementation and Impact on Care of Patients With Neuroendocrine Tumors.

Journal Article AJR Am J Roentgenol · August 2019 OBJECTIVE. The purpose of this article is to enhance knowledge of the clinical implementation of peptide receptor radionuclide therapy (PRRT) and its impact on care of patients with neuroendocrine tumors. CONCLUSION. Most well differentiated and some moder ... Full text Link to item Cite

Multicenter Trial of [18F]fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Staging of Head and Neck Cancer and Negative Predictive Value and Surgical Impact in the N0 Neck: Results From ACRIN 6685.

Journal Article J Clin Oncol · July 10, 2019 PURPOSE: The objective of this study was to determine the negative predictive value (NPV) of positron emission tomography (PET)/computed tomography (CT) for the clinically N0 neck on the basis of neck dissection. METHODS: Participants with newly diagnosed, ... Full text Link to item Cite

Tumor Heterogeneity on FDG PET/CT and Immunotherapy: An Imaging Biomarker for Predicting Treatment Response in Patients With Metastatic Melanoma.

Journal Article AJR Am J Roentgenol · June 2019 OBJECTIVE. The purpose of this study is to evaluate the ability of quantitative 18F-FDG PET parameters to predict outcomes of patients with malignant melanoma who have been treated with immune modulation therapy. MATERIALS AND METHODS. We retrospectively i ... Full text Link to item Cite

ACR Appropriateness Criteria® Thyroid Disease.

Journal Article J Am Coll Radiol · May 2019 There are a wide variety of diseases that affect the thyroid gland ranging from hyperplastic to neoplastic, autoimmune, or inflammatory. They can present with functional abnormality or a palpable structural change. Imaging has a key role in diagnosing and ... Full text Link to item Cite

Timing and Impact of Posttreatment PET/CT After First 6 Months on Patient Management and Outcomes in Oropharyngeal Squamous Cell Carcinoma.

Conference AJR Am J Roentgenol · May 2019 OBJECTIVE. The objective of this study was to investigate the impact of PET/CT on patient management and outcomes of oropharyngeal squamous cell carcinoma (OPSCC) after the first 6 months following treatment. MATERIALS AND METHODS. We retrospectively ident ... Full text Link to item Cite

ACR Appropriateness Criteria® Neck Mass-Adenopathy.

Journal Article J Am Coll Radiol · May 2019 A palpable neck mass may be the result of neoplastic, congenital, or inflammatory disease. Older age suggests neoplasia, and a congenital etiology is more prevalent in the pediatric population. The imaging approach is based on the patient age, mass locatio ... Full text Link to item Cite

ACR Appropriateness Criteria® Neuroendocrine Imaging.

Journal Article J Am Coll Radiol · May 2019 Neuroendocrine dysfunction includes suspected hyper- and hypofunction of the pituitary gland. Causative lesions may include primary masses of the pituitary such as pituitary microadenomas and macroadenomas, as well as extrinsic masses, typically centered i ... Full text Link to item Cite

Prognostic modeling for patients with colorectal liver metastases incorporating FDG PET radiomic features.

Journal Article Eur J Radiol · April 2019 OBJECTIVE: We aimed to improve prediction of outcome for patients with colorectal liver metastases, via prognostic models incorporating PET-derived measures, including radiomic features that move beyond conventional standard uptake value (SUV) measures. PA ... Full text Link to item Cite

American College of Radiology Appropriateness Criteria: Advancing Evidence-Based Imaging Practice.

Journal Article Semin Nucl Med · March 2019 ACR Appropriateness Criteria (ACR AC) are evidence-based guidelines to assist referring physicians, other providers, and patients in making the most appropriate imaging or treatment decision for a specific clinical condition. The ACR AC are created by expe ... Full text Link to item Cite

Skeletal Metastasis Evaluation: Value and Impact of PET/Computed Tomography on Diagnosis, Management and Prognosis.

Journal Article PET Clin · January 2019 A number of PET agents are useful for evaluation of skeletal metastatic disease, and have significant advantages over 99mTc-MDP scintigraphy, including superior diagnostic accuracy, higher spatial resolution, and shorter imaging times- often with the abili ... Full text Link to item Cite

Practical Considerations for Integrating PET/CT into Radiation Therapy Planning.

Journal Article J Nucl Med Technol · December 2018 Over the past 20 y, PET/CT has had many technologic and developmental advancements for patient care. PET/CT has evolved from being used as a diagnosis and staging tool to now having an impact on treating cancer through a collaboration with radiation oncolo ... Full text Link to item Cite

ACR-ACNM Practice Parameter for the Performance of Fluorine-18 Fluciclovine-PET/CT for Recurrent Prostate Cancer.

Journal Article Clin Nucl Med · December 2018 The American College of Radiology (ACR) and American College of Nuclear Medicine (ACNM) collaborated to develop a clinical practice document for the performance of fluciclovine positron-emission tomography (PET) / computed tomography (CT) in the evaluation ... Full text Link to item Cite

ACR Practice Parameter for the Performance of Gallium-68 DOTATATE PET/CT for Neuroendocrine Tumors.

Journal Article Clin Nucl Med · December 2018 Radiopharmaceuticals targeting cell surface expression of somatostatin receptors (SSTRs) are particularly useful in the evaluation of neuroendocrine tumors. Gallium-68 DOTA-Tyr-octreotatate (Ga-DOTATATE) primarily binds to SSTR type 2 receptors. Ga DOTATAT ... Full text Link to item Cite

Update 2018: 18F-FDG PET/CT and PET/MRI in Head and Neck Cancer.

Journal Article Clin Nucl Med · December 2018 There are recent advances, namely, a standardized method for reporting therapy response (Hopkins criteria), a multicenter prospective cohort study with excellent negative predictive value of F-FDG PET/CT for N0 clinical neck, a phase III multicenter random ... Full text Link to item Cite

68Ga-PSMA PET/CT and PET/MRI in high-risk prostate cancer patients.

Journal Article Nucl Med Commun · October 2018 Treatment of high-risk prostate cancer (HRPCa) is challenging. Local staging and metastatic evaluation are important for the patient management. Recently, prostate-specific membrane antigen (PSMA)-based imaging modalities such as PSMA PET/CT and PET/MRI ha ... Full text Link to item Cite

Impact of DAT-SPECT on Management of Patients Suspected of Parkinsonism.

Journal Article Clin Nucl Med · October 2018 OBJECTIVE: To evaluate the value of I-2β-carbomethoxy-3β-(4-iodophenyl)-N-(3-fluoropropyl) nortropane (I-FP-CIT) dopamine transporter single photon emission computed tomography (DAT-SPECT) to change management strategies of patients suspected of parkinsoni ... Full text Link to item Cite

Neuroendocrine Tumor Diagnosis and Management: 68Ga-DOTATATE PET/CT.

Journal Article AJR Am J Roentgenol · August 2018 OBJECTIVE: The purpose of this article is to provide a review of the use of 68Ga tetraazacyclododecanetetraacetic acid-DPhe1-Tyr3-octreotate (DOTATATE) PET/CT, a functional imaging modality for assessment of well-differentiated neuroendocrine tumors (NETs) ... Full text Link to item Cite

PET/CT of Dementia.

Journal Article AJR Am J Roentgenol · August 2018 OBJECTIVE: In this article, we review the literature on PET/CT in the management of dementia, present evidence for best clinical practices, and discuss recent advances in the field. CONCLUSION: Standard-of-care imaging for dementia includes CT and MRI, pri ... Full text Link to item Cite

Intended Versus Inferred Treatment After 18F-Fluoride PET Performed for Evaluation of Osseous Metastatic Disease in the National Oncologic PET Registry.

Journal Article J Nucl Med · March 2018 We have previously reported that PET with 18F-fluoride (NaF PET) for assessment of osseous metastatic disease led to changes in intended management in a substantial fraction of patients with prostate or other types of cancer participating in the National O ... Full text Link to item Cite

Hospice Admission and Survival After 18F-Fluoride PET Performed for Evaluation of Osseous Metastatic Disease in the National Oncologic PET Registry.

Journal Article J Nucl Med · March 2018 We have previously reported that PET using 18F-fluoride (NaF PET) for assessment of osseous metastatic disease was associated with substantial changes in intended management in Medicare beneficiaries participating in the National Oncologic PET Registry (NO ... Full text Link to item Cite

Quantitative PET/CT in clinical practice: assessing the agreement of PET tumor indices using different clinical reading platforms.

Journal Article Nucl Med Commun · February 2018 OBJECTIVE: The aim of this study was to determine whether various fluorine-18-fluorodeoxyglucose PET/CT-derived parameters used in oncology vary significantly depending on the interpretation software systems used in clinical practice for multiple human sol ... Full text Link to item Cite

Role of FDG PET/CT in the Eighth Edition of TNM Staging of Non-Small Cell Lung Cancer.

Journal Article Radiographics · 2018 Lung cancer is the leading cause of cancer-related mortality in the United States, and accurate staging plays a vital role in determining prognosis and treatment. The recently revised eighth edition of the TNM staging system for lung cancer defines new T a ... Full text Link to item Cite

ACR-SPR-STR Practice Parameter for the Performance of Cardiac Positron Emission Tomography - Computed Tomography (PET/CT) Imaging.

Journal Article Clin Nucl Med · December 2017 This clinical practice parameter has been developed collaboratively by the American College of Radiology (ACR), the Society for Pediatric Radiology (SPR), and the Society of Thoracic Radiology (STR). This document is intended to act as a guide for physicia ... Full text Link to item Cite

Adapting a Standardized, Industry-Proven Tool to Measure Patients' Perceptions of Quality at the Point of Care in a PET/CT Center.

Journal Article J Nucl Med Technol · December 2017 Patient satisfaction with health-care delivery is essential today. Using a psychometrically validated questionnaire-SERVPERF-we quantitatively measured patients' perceptions of the quality of service at the point of care in a PET/CT center, and we used thi ... Full text Link to item Cite

ACR-ACNM Practice Parameter for the Performance of Dopamine Transporter (DaT) Single Photon Emission Computed Tomography (SPECT) Imaging for Movement Disorders.

Journal Article Clin Nucl Med · November 2017 This American College of Radiology and American College of Nuclear Medicine joint clinical practice parameter is for performance of dopamine transporter single photon emission computed tomography (SPECT) imaging, for patients with movement disorders. Parki ... Full text Link to item Cite

ACR Appropriateness Criteria® Sinonasal Disease.

Journal Article J Am Coll Radiol · November 2017 Imaging of sinonasal pathology may occur for assessment of rhinosinusitis or mass lesions. Rhinosinusitis is prevalent in up to 16% of the US population with annual economic burdens estimated at 22 billion dollars. Rhinosinusitis is characterized as acute ... Full text Link to item Cite

PET/Computed Tomography Scanning and Precision Medicine: Esophageal Cancer.

Journal Article PET Clin · October 2017 Esophageal cancer commonly has a poor prognosis, which requires an accurate diagnosis and early treatment to improve outcome. Other modalities for staging, such as endoscopic ultrasound imaging and computed tomography (CT) scans, have a role in diagnosis a ... Full text Link to item Cite

Precision Medicine and PET-Computed Tomography in Pediatric Malignancies.

Journal Article PET Clin · October 2017 Fluorine-18 fluorodeoxyglucose (18F-FDG) PET-computed tomography (CT) plays a significant role in diagnosis, staging, therapy selection, and therapy assessment of multiple pediatric malignancies and facilitating precision medicine delivery in pediatric pat ... Full text Link to item Cite

PET/Computed Tomography and Precision Medicine: Musculoskeletal Sarcoma.

Journal Article PET Clin · October 2017 Skeletal and soft tissue sarcomas need early and accurate diagnosis, staging, and treatment for optimal outcome. 18F-FDG PET/computed tomography (CT) is indicated in staging of patients with high-grade sarcomas and acts as a surrogate marker of histopathol ... Full text Link to item Cite

Precision Medicine and PET/Computed Tomography in Melanoma.

Journal Article PET Clin · October 2017 Recent advances in genomic profiling and sequencing of melanoma have provided new insights into the development of the basis for molecular biology to more accurately subgroup patients with melanoma. The development of novel mutation-targeted and immunomodu ... Full text Link to item Cite

PET/Computed Tomography and Precision Medicine: Gastric Cancer.

Journal Article PET Clin · October 2017 Gastric cancer is a disease with low survival rates and high morbidity, requiring accurate and prompt diagnosis and treatment. Although limited in the evaluation of the primary tumor as such, the metabolic information of primary tumors in an 18F-FDG PET/CT ... Full text Link to item Cite

PET-Computed Tomography and Precision Medicine in Pancreatic Adenocarcinoma and Pancreatic Neuroendocrine Tumors.

Journal Article PET Clin · October 2017 18F-FDG PET/CT has been described as an accurate tool for initial diagnosis of pancreatic adenocarcinoma. It differentiates benign from malignant causes; detects local and, especially, distant spread of disease; and is a very good predictor of patient prog ... Full text Link to item Cite

Clinical Practice in PET/CT for the Management of Head and Neck Squamous Cell Cancer.

Journal Article AJR Am J Roentgenol · August 2017 OBJECTIVE: The purpose of this article is to summarize the evidence for the value of PET/CT for the management of patients with head and neck squamous cell cancer and suggest best clinical practices. CONCLUSION: FDG PET/CT is a valuable imaging tool for id ... Full text Link to item Cite

Comparative effectiveness: 18F-FDG-PET/CT versus CT for post-treatment follow-up of patients with lung cancer.

Journal Article Nucl Med Commun · August 2017 PURPOSE: This study aimed to evaluate the comparative effectiveness of follow-up fluorine-18-fluorodeoxyglucose (F-FDG)-PET/CT and chest CT in the detection of local, regional, and distant metastatic diseases in lung cancer. PATIENTS AND METHODS: Follow-up ... Full text Link to item Cite

Clinical Indications and Impact on Management: Fourth and Subsequent Posttherapy Follow-up 18F-FDG PET/CT Scans in Oncology Patients.

Journal Article J Nucl Med · May 2017 The Centers for Medicare and Medicaid Services coverage includes 3 posttherapy 18F-FDG PET/CT scans per patient and per tumor type. Any additional follow-up 18F-FDG PET/CT scans will be reimbursed at the discretion of a local Medicare administrator, if dee ... Full text Link to item Cite

Value of Intratumoral Metabolic Heterogeneity and Quantitative 18F-FDG PET/CT Parameters to Predict Prognosis in Patients With HPV-Positive Primary Oropharyngeal Squamous Cell Carcinoma.

Journal Article Clin Nucl Med · May 2017 OBJECTIVE: The aim of this study was to evaluate the impact of intratumoral metabolic heterogeneity and quantitative FDG PET/CT imaging parameters for predicting patient outcomes in primary oropharyngeal squamous cell cancer (OPSCC). PATIENTS AND METHODS: ... Full text Link to item Cite

Role of Imaging in the Era of Precision Medicine.

Journal Article Acad Radiol · May 2017 Precision medicine is an emerging approach for treating medical disorders, which takes into account individual variability in genetic and environmental factors. Preventive or therapeutic interventions can then be directed to those who will benefit most fro ... Full text Link to item Cite

Post-treatment 18F-FDG-PET/CT versus contrast-enhanced CT in patients with oropharyngeal squamous cell carcinoma: comparative effectiveness study.

Journal Article Nucl Med Commun · March 2017 OBJECTIVE: To compare the accuracy of same-day therapy-assessment PET/computed tomography (PET/CT) and conventional contrast-enhanced computed tomography (CECT) in patients with oropharyngeal squamous cell carcinoma (OPSCC). METHODS: A total of 110 (95 men ... Full text Link to item Cite

The Value of FDG PET/CT in Treatment Response Assessment, Follow-Up, and Surveillance of Lung Cancer.

Journal Article AJR Am J Roentgenol · February 2017 OBJECTIVE: The purpose of this article is to summarize the evidence regarding the role of FDG PET/CT in treatment response assessment and surveillance of lung cancer and to provide suggested best practices. CONCLUSION: FDG PET/CT is a valuable imaging tool ... Full text Link to item Cite

Spatiotemporal distribution modeling of PET tracer uptake in solid tumors.

Journal Article Ann Nucl Med · February 2017 OBJECTIVE: Distribution of PET tracer uptake is elaborately modeled via a general equation used for solute transport modeling. This model can be used to incorporate various transport parameters of a solid tumor such as hydraulic conductivity of the microve ... Full text Link to item Cite

Practical no-gold-standard evaluation framework for quantitative imaging methods: application to lesion segmentation in positron emission tomography.

Journal Article J Med Imaging (Bellingham) · January 2017 Recently, a class of no-gold-standard (NGS) techniques have been proposed to evaluate quantitative imaging methods using patient data. These techniques provide figures of merit (FoMs) quantifying the precision of the estimated quantitative value without re ... Full text Link to item Cite

Molecular Imaging and Precision Medicine: PET/Computed Tomography and Therapy Response Assessment in Oncology.

Journal Article PET Clin · January 2017 A variety of methods have been developed to assess tumor response to therapy. Standardized qualitative criteria based on 18F-fluoro-deoxyglucose PET/computed tomography have been proposed to evaluate the treatment effectiveness in specific cancers and thes ... Full text Link to item Cite

Molecular Imaging and Precision Medicine in Head and Neck Cancer.

Journal Article PET Clin · January 2017 The concept of using tumor genomic profiling information has revolutionized personalized cancer treatment. Head and neck (HN) cancer management is being influenced by recent discoveries of activating mutations in epidermal growth factor receptor and relate ... Full text Link to item Cite

Precision Medicine and PET/Computed Tomography: Challenges and Implementation.

Journal Article PET Clin · January 2017 Precision Medicine is about selecting the right therapy for the right patient, at the right time, specific to the molecular targets expressed by disease or tumors, in the context of patient's environment and lifestyle. Some of the challenges for delivery o ... Full text Link to item Cite

18F-FDG PET/CT Metabolic Tumor Volume and Intratumoral Heterogeneity in Pancreatic Adenocarcinomas: Impact of Dual-Time Point and Segmentation Methods.

Journal Article Clin Nucl Med · January 2017 OBJECTIVES: We aimed to determine the consistency of quantitative PET measurements of metabolic tumor volume (MTV) and intratumoral heterogeneity index for primary untreated pancreatic adenocarcinomas, when using dual-time point F-FDG PET/CT imaging. METHO ... Full text Link to item Cite

Genomic alterations in human epidermal growth factor receptor 2 (HER2/ERBB2) in head and neck squamous cell carcinoma.

Journal Article Head Neck · January 2017 BACKGROUND: Despite recent advances, survival outcomes for those with metastatic or recurrent head and neck squamous cell carcinoma (HNSCC) have remained poor. Novel approaches should be investigated to improve outcomes. METHODS: A retrospective chart revi ... Full text Link to item Cite

Hepatobiliary Cancer

Chapter · January 1, 2017 Hepatocellular carcinoma (HCC) is the sixth most common malignancy in Asia and Africa and constitutes 70%-85% of primary liver cancers. In addition to clinical information, benign findings and pitfalls in PET/CT reading using various radiotracers, and teac ... Full text Cite

Head and Neck Cancers

Chapter · January 1, 2017 Head and neck cancers are the sixth most common cancers among males. The role of fludeoxyglucose (FDG) PET/CT imaging in staging, therapy monitoring, radiation therapy planning, and long-term follow-up evaluation of head and neck squamous cell carcinoma (S ... Full text Cite

Value of FDG PET/CT in the Management of Mesothelioma

Journal Article Journal of Pharmacy and Pharmacology · November 28, 2016 Full text Cite

Prevention Strategies for Contrast-Induced Nephropathy.

Journal Article Ann Intern Med · October 18, 2016 Full text Link to item Cite

Effect of tumor size on drug delivery to lung tumors

Conference 2015 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2015 · October 3, 2016 Drug delivery to solid tumors can be expressed physically using biomechanical phenomena such as convection, diffusion of drug in extracellular matrices, and drug extravasation from microvessels. Applying computational methods to solve governing conservatio ... Full text Cite

Impact on Patient Management of [18F]-Fluorodeoxyglucose-Positron Emission Tomography (PET) Used for Cancer Diagnosis: Analysis of Data From the National Oncologic PET Registry.

Journal Article Oncologist · September 2016 INTRODUCTION: We assessed the impact of [(18)F]-fluorodeoxyglucose (FDG)-positron emission tomography (PET) on intended management of patients in the National Oncologic PET Registry (NOPR) for three different diagnostic indications: (a) determining whether ... Full text Link to item Cite

Therapy Response Assessment and Patient Outcomes in Head and Neck Squamous Cell Carcinoma: FDG PET Hopkins Criteria Versus Residual Neck Node Size and Morphologic Features.

Journal Article AJR Am J Roentgenol · September 2016 OBJECTIVE: This study investigates the prognostic value of (18)F-FDG PET/CT qualitative therapy assessment (Hopkins criteria) in patients with head and neck squamous cell carcinomas (HNSCCs) with residual neck nodes after definitive chemoradiation therapy ... Full text Link to item Cite

18F-FDG PET/CT and Melanoma: Value of Fourth and Subsequent Posttherapy Follow-up Scans for Patient Management.

Journal Article Clin Nucl Med · September 2016 PURPOSE: We aimed to evaluate the added value of performing fourth and subsequent follow-up F-FDG-PET/CT scans to clinical assessment and impact on the patient's management in patients with melanoma. METHODS: This was a retrospective study of 232 biopsy-pr ... Full text Link to item Cite

FDG-PET/CT and MRI for Evaluation of Pathologic Response to Neoadjuvant Chemotherapy in Patients With Breast Cancer: A Meta-Analysis of Diagnostic Accuracy Studies.

Journal Article Oncologist · August 2016 INTRODUCTION: This study compared the diagnostic test accuracy of magnetic resonance imaging (MRI) with that of (18)F-fluoro-2-glucose-positron emission tomography/computed tomography (FDG-PET/CT) imaging in assessment of response to neoadjuvant chemothera ... Full text Link to item Cite

JOURNAL CLUB: Value of Quantitative FDG PET/CT Volumetric Biomarkers in Recurrent Colorectal Cancer Patient Survival.

Journal Article AJR Am J Roentgenol · August 2016 OBJECTIVE: The purpose of this study was to evaluate the impact of quantitative PET parameters in the overall survival of patients with recurrent colorectal cancer. MATERIALS AND METHODS: A total of 105 patients with a biopsy-proven recurrence of colorecta ... Full text Link to item Cite

The Current and Evolving Role of PET in Personalized Management of Lung Cancer.

Journal Article PET Clin · July 2016 Using tumor genomic profiling information has revolutionized the landscape of personalized treatment of lung cancer. The management of lung cancer and non-small cell lung cancer particularly is influenced by discoveries of activating mutations in epidermal ... Full text Link to item Cite

The value of fourth and subsequent post-treatment 18F-FDG PET/CT scans in the management of patients with non-Hodgkin's lymphoma.

Journal Article Nucl Med Commun · July 2016 OBJECTIVE: To evaluate the impact of fourth and subsequent follow-up PET/computed tomography (PET/CT) scans in patients with non-Hodgkins lymphoma (NHL). MATERIALS AND METHODS: This retrospective study evaluated all biopsy-proven NHL patients who had more ... Full text Link to item Cite

18F-FDG PET/CT: Therapy Response Assessment Interpretation (Hopkins Criteria) and Survival Outcomes in Lung Cancer Patients.

Journal Article J Nucl Med · June 2016 UNLABELLED: The purpose of this study was to evaluate the value of an (18)F-FDG PET/CT-based interpretation system (Hopkins criteria) to assess the therapy response and survival in lung cancer. METHODS: This is an Institutional Review Board-approved, retro ... Full text Link to item Cite

Value of fourth and subsequent post-therapy follow-up 18F-FDG PET/CT scans in patients with breast cancer.

Journal Article Nucl Med Commun · June 2016 OBJECTIVE: To evaluate the accuracy and value of the fourth and subsequent post-therapy follow-up fluorine-18 fluorodeoxyglucose (F-FDG) PET/computed tomography (CT) scans in the clinical assessment of breast cancer patients. MATERIALS AND METHODS: Ninety- ... Full text Link to item Cite

FDG PET/CT in Patients With Head and Neck Squamous Cell Carcinoma After Primary Surgical Resection With or Without Chemoradiation Therapy.

Journal Article AJR Am J Roentgenol · May 2016 OBJECTIVE: The purpose of this study was to assess the value of posttreatment FDG PET/CT in patients with squamous cell carcinoma of the head and neck (HNSCC) treated with primary surgical resection with or without adjuvant concurrent chemoradiotherapy. MA ... Full text Link to item Cite

FDG Avidity and Tumor Burden: Survival Outcomes for Patients With Recurrent Breast Cancer.

Journal Article AJR Am J Roentgenol · April 2016 OBJECTIVE: The objective of this study was to assess the value of quantitative PET parameters in the prediction of survival for patients with recurrent breast cancer. MATERIALS AND METHODS: We conducted a retrospective study of 78 women who had recurrent b ... Full text Link to item Cite

Effectiveness of Prevention Strategies for Contrast-Induced Nephropathy: A Systematic Review and Meta-analysis.

Journal Article Ann Intern Med · March 15, 2016 BACKGROUND: N-acetylcysteine, sodium bicarbonate, statins, and ascorbic acid have been studied for reducing contrast-induced nephropathy (CIN). PURPOSE: To evaluate the comparative effectiveness of interventions to reduce CIN in adults receiving contrast m ... Full text Link to item Cite

Comparative Effect of Contrast Media Type on the Incidence of Contrast-Induced Nephropathy: A Systematic Review and Meta-analysis.

Journal Article Ann Intern Med · March 15, 2016 BACKGROUND: Iodine contrast media are essential components of many imaging procedures. An important potential side effect is contrast-induced nephropathy (CIN). PURPOSE: To compare CIN risk for contrast media within and between osmolality classes in patien ... Full text Link to item Cite

Comprehensive modeling of the spatiotemporal distribution of PET tracer uptake in solid tumors based on the convection-diffusion-reaction equation

Conference 2014 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2014 · March 10, 2016 In this paper, the distribution of PET tracer uptake is elaborately modeled via a general equation used for solute transport modeling. This model can be used to incorporate various transport parameters of a solid tumor such as hydraulic conductivity of the ... Full text Cite

A generalized total effective entrapment metric (gTEE) to quantify burden of homogeneous and heterogeneous tumors in PET imaging for enhanced clinical outcome prediction

Conference 2014 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2014 · March 10, 2016 Oncoloc PET images provide valuable information that can enable enhanced prognosis of disease. Nonetheless, such information is commonly simplified significantly in routine clinical assessment to meet workflow constraints. Examples for typical FDG PET metr ... Full text Cite

Impact of point spread function reconstruction on quantitative 18F-FDG-PET/CT imaging parameters and inter-reader reproducibility in solid tumors.

Journal Article Nucl Med Commun · March 2016 INTRODUCTION: This study aims to determine the impact of point-spread function (PSF) reconstruction on quantitative PET/computed tomography (CT) indices and the inter-reader reproducibility of these measurements. MATERIALS AND METHODS: The study was approv ... Full text Link to item Cite

18F-FDG-PET/CT therapy assessment of locally advanced pancreatic adenocarcinoma: impact on management and utilization of quantitative parameters for patient survival prediction.

Journal Article Nucl Med Commun · March 2016 OBJECTIVES: This study aims to evaluate the impact of therapy assessment PET/computed tomography (CT) scan on the management of locally advanced pancreatic adenocarcinoma (LAPC), and the value of qualitative versus quantitative PET/CT interpretation for pa ... Full text Link to item Cite

ACR-ASNR Practice Parameter for Brain PET/CT Imaging Dementia.

Journal Article Clin Nucl Med · February 2016 This practice parameter is for both FDG and amyloid brain PET or PET/computed tomography (CT) for patients with cognitive decline, and has been developed collaboratively by the American College of Radiology (ACR) and the American Society for Neuroradiology ... Full text Link to item Cite

Serum Antibodies to HPV16 Early Proteins Warrant Investigation as Potential Biomarkers for Risk Stratification and Recurrence of HPV-Associated Oropharyngeal Cancer.

Journal Article Cancer Prev Res (Phila) · February 2016 Human papillomavirus (HPV) is responsible for increasing incidence of oropharyngeal cancer. At present, there are no biomarkers in the surveillance algorithm for HPV-positive oropharyngeal cancer (HPV-OPC). HPV16 E6 antibody precedes oropharyngeal cancer d ... Full text Link to item Cite

Follow-up FDG PET/CT in Patients With Non-Hodgkin Lymphoma: Value to Clinical Assessment and Patient Management.

Journal Article Clin Nucl Med · February 2016 OBJECTIVE: The aim of this study was to evaluate the value of each follow-up PET/CT in the clinical assessment of recurrence as well as determining its impact on management in patients with non-Hodgkin lymphoma (NHL). PATIENTS AND METHODS: All patients dia ... Full text Link to item Cite

A novel metric for quantification of homogeneous and heterogeneous tumors in PET for enhanced clinical outcome prediction.

Journal Article Phys Med Biol · January 7, 2016 Oncologic PET images provide valuable information that can enable enhanced prognosis of disease. Nonetheless, such information is simplified significantly in routine clinical assessment to meet workflow constraints. Examples of typical FDG PET metrics incl ... Full text Link to item Cite

Do Radiologists Have Stage Fright? Tumor Staging and How We Can Add Value to the Care of Patients with Cancer.

Journal Article Radiology · January 2016 With current shifts in our health care system and a growing national discussion around the concept of the value of imaging, it is time for radiologists and nuclear medicine physicians to recognize and accept our role in the multidisciplinary oncology team. ... Full text Open Access Link to item Cite

The Role of Positron Emission Tomography/Computed Tomography in Management and Prediction of Survival in Pancreatic Cancer.

Journal Article J Comput Assist Tomogr · 2016 The role of positron emission tomography (PET) and PET/computed tomography (CT) in the management of pancreatic cancer patients has not been clearly established. Although value of PET/CT in the staging of pancreatic cancer is still being debated, several s ... Full text Link to item Cite

Use of 18F-Fludeoxyglucose-Positron Emission Tomography/Computed Tomography for Patient Management and Outcome in Oropharyngeal Squamous Cell Carcinoma: A Review.

Journal Article JAMA Otolaryngol Head Neck Surg · January 2016 18F-fludeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT) has been performed widely in diagnosis and management of patients with oropharyngeal squamous cell carcinoma (OPSCC). This review summarizes the literature on this tool in th ... Full text Link to item Cite

Contrast-Induced Nephropathy: Comparative Effectiveness of Preventive Measures

Journal Article · 2016 ObjectiveTo evaluate the comparative effectiveness of interventions (intravenous [IV] fluids, N-acetylcysteine, sodium bicarbonate, and statins, among others) to reduce the risk of contrast-induced nephropathy (CIN), need for renal replacement the ... Cite

Authors' Reply.

Journal Article J Am Coll Radiol · December 2015 Full text Link to item Cite

Visualization of the Oropharynx With Transcervical Ultrasound.

Journal Article AJR Am J Roentgenol · December 2015 OBJECTIVE: The purposes of this article are to illustrate the sonographic appearance of the oropharynx and to discuss the potential role of ultrasound in evaluation of the oropharynx. CONCLUSION: Ultrasound is not currently used in the standard clinical ev ... Full text Link to item Cite

The value of follow-up FDG-PET/CT in the management and prognosis of patients with HPV-positive oropharyngeal squamous cell carcinoma.

Journal Article J Med Imaging Radiat Oncol · December 2015 INTRODUCTION: To establish the accuracy of follow-up fluorodeoxyglucose (FDG) positron emission tomography (PET)/CT and the impact of FDG PET/CT result on management decisions and patient outcome prediction (overall and progression free survival) in human ... Full text Link to item Cite

Intratherapy or Posttherapy FDG PET or FDG PET/CT for Patients With Head and Neck Cancer: A Systematic Review and Meta-analysis of Prognostic Studies.

Journal Article AJR Am J Roentgenol · November 2015 OBJECTIVE: The objective of this study was to determine the predictive value of intra-therapy or posttherapy FDG PET or FDG PET/CT with regard to overall survival (OS) and event-free survival (EFS) outcomes for patients with head and neck cancer (HNC). MAT ... Full text Link to item Cite

Repeatability of hypoxia PET imaging using [¹⁸F]HX4 in lung and head and neck cancer patients: a prospective multicenter trial.

Journal Article Eur J Nucl Med Mol Imaging · November 2015 PURPOSE: Hypoxia is an important factor influencing tumor progression and treatment efficacy. The aim of this study was to investigate the repeatability of hypoxia PET imaging with [(18)F]HX4 in patients with head and neck and lung cancer. METHODS: Nine pa ... Full text Link to item Cite

Diagnostic Accuracy of Follow-Up FDG PET or PET/CT in Patients With Head and Neck Cancer After Definitive Treatment: A Systematic Review and Meta-Analysis.

Journal Article AJR Am J Roentgenol · September 2015 OBJECTIVE: The purpose of this study was to assess the diagnostic performance of FDG PET or PET/CT for detection of local, regional, and distant recurrences in the follow-up of patients with head and neck cancer who underwent definitive treatment. MATERIAL ... Full text Link to item Cite

Repeatability of 18F-FDG PET/CT in Advanced Non-Small Cell Lung Cancer: Prospective Assessment in 2 Multicenter Trials.

Journal Article J Nucl Med · August 2015 UNLABELLED: PET/CT with the glucose analog (18)F-FDG has several potential applications for monitoring tumor response to therapy in patients with non-small cell lung cancer (NSCLC). A prerequisite for many of these applications is detailed knowledge of the ... Full text Link to item Cite

FDG PET/CT for Management and Assessing Outcomes of Squamous Cell Cancer of the Oral Cavity.

Journal Article AJR Am J Roentgenol · August 2015 OBJECTIVE: FDG PET/CT has excellent diagnostic accuracy for detecting locoregional nodal and distant metastases, can be used to assess therapeutic response, and provides valuable information about prognosis in patients with oral cavity cancer. The aim of t ... Full text Link to item Cite

(18)F-FDG PET/CT and Melanoma: Staging, Immune Modulation and Mutation-Targeted Therapy Assessment, and Prognosis.

Journal Article AJR Am J Roentgenol · August 2015 OBJECTIVE: Monoclonal antibodies that target the programmed cell death 1 (PD-1) immune checkpoint protein and its associated ligands, PD-L1 and PD-L2, and targeted inhibitors of mutated signal transduction molecules such as BRAF inhibitors show immense pro ... Full text Link to item Cite

¹⁸F-FDG PET/CT and Colorectal Cancer: Value of Fourth and Subsequent Posttherapy Follow-up Scans for Patient Management.

Journal Article J Nucl Med · July 2015 UNLABELLED: The purpose of this study was to evaluate the added value of a fourth and subsequent follow-up PET/CT scans to clinical assessment and impact on patient management in patients with colorectal cancer. METHODS: This was an institutional review bo ... Full text Link to item Cite

FDG PET/CT in Pancreatic and Hepatobiliary Carcinomas: Value to Patient Management and Patient Outcomes.

Journal Article PET Clin · July 2015 Fludeoxyglucose F 18 ((18)F-FDG) PET/CT has not been shown to offer additional benefit in the initial diagnosis of pancreatic cancer, but studies show benefit of (18)F-FDG PET/CT in initial staging and patient prognosis. There is evidence for (18)F-FDG PET ... Full text Link to item Cite

Value of FDG PET/CT in Patient Management and Outcome of Skeletal and Soft Tissue Sarcomas.

Journal Article PET Clin · July 2015 Fluorodeoxyglucose (FDG)-PET/computed tomography (CT) has been increasingly used in bone and soft tissue sarcomas and provides advantages in the initial tumor staging, tumor grading, therapy assessment, and recurrence detection. FDG-PET/CT metabolic parame ... Full text Link to item Cite

(18)F-Flourodeoxy-Glucose PET/Computed Tomography in Brain Tumors: Value to Patient Management and Survival Outcomes.

Journal Article PET Clin · July 2015 (18)F-flourodeoxy-glucose (FDG) PET/computed tomography (CT) is most useful in the evaluation of primary central nervous system (CNS) lymphoma, important in diagnosis, pretherapy prognosis, and therapy response evaluation. Utility in working up gliomas is ... Full text Link to item Cite

Genomic alterations in head and neck squamous cell carcinoma determined by cancer gene-targeted sequencing.

Journal Article Ann Oncol · June 2015 BACKGROUND: To determine genomic alterations in head and neck squamous cell carcinoma (HNSCC) using formalin-fixed, paraffin-embedded (FFPE) tumors obtained through routine clinical practice, selected cancer-related genes were evaluated and compared with a ... Full text Link to item Cite

Fluorodeoxyglucose positron emission tomography/computerized tomography in differentiated thyroid cancer management: Importance of clinical justification and value in predicting survival.

Journal Article J Med Imaging Radiat Oncol · June 2015 INTRODUCTION: The purpose of this study was to evaluate the added value of follow-up fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) to clinical assessment and predicting survival outcome in patients with differentiated thy ... Full text Link to item Cite

Prognostic Value of FDG PET/CT-Derived Parameters in Pancreatic Adenocarcinoma at Initial PET/CT Staging.

Journal Article AJR Am J Roentgenol · May 2015 OBJECTIVE: The purpose of this study is to evaluate the performance of PET-derived parameters as prognostic markers for overall survival (OS) and progression-free survival (PFS) outcome in patients with pancreatic adenocarcinoma. MATERIALS AND METHODS: We ... Full text Link to item Cite

Giant cell arteritis mimicking infiltrative leptomeningeal disease of the optic nerves.

Journal Article BMJ Case Rep · April 9, 2015 A 67-year-old man presented with several days of progressive, painless left eye vision loss. He reported mild jaw claudication but denied headache, scalp tenderness or constitutional symptoms. Examination revealed palpable temporal arteries, blurring of th ... Full text Link to item Cite

Value of Fluorodeoxyglucose PET/Computed Tomography Patient Management and Outcomes in Thyroid Cancer.

Journal Article PET Clin · April 2015 "Fluorodeoxyglucose (FDG) PET/computed tomography (CT) is used most frequently in the surveillance of iodine-refractory differentiated thyroid cancer with increased thyroglobulin level after therapy. This article evaluates the impact of FDG-PET/CT on clini ... Full text Link to item Cite

PET with Fluorodeoxyglucose F 18/Computed Tomography in the Clinical Management and Patient Outcomes of Esophageal Cancer.

Journal Article PET Clin · April 2015 PET with fluorodeoxyglucose F 18/computed tomography ((18)F-FDG PET/CT) has evolved into an indispensable imaging technique in the management of patients with esophageal cancer. Staging with (18)F-FDG PET/CT is strongly associated with overall survival and ... Full text Link to item Cite

18F FDG PET/CT and Head and Neck Cancer: Patient Management and Outcomes.

Journal Article PET Clin · April 2015 There is a growing body of evidence that point to the value of 18F fluoro-deoxyglucose-PET/CT in the management of head and neck cancer (HNC) patients and predicting patient-related outcomes. FDG-PET/CT changes the baseline staging (compared with CT or MR ... Full text Link to item Cite

Two-time-point FDG PET/CT: liver SULmean repeatability.

Journal Article AJR Am J Roentgenol · February 2015 OBJECTIVE. The purpose of this study was to evaluate the repeatability of liver mean standardized uptake value normalized to lean body mass (SULmean) in the same patients at different time points within the right lobe of the liver at (18)F-FDG PET/CT, in a ... Full text Link to item Cite

18F-FDG PET/CT and lung cancer: value of fourth and subsequent posttherapy follow-up scans for patient management.

Journal Article J Nucl Med · February 2015 UNLABELLED: The Centers for Medicare and Medicaid Services recently ruled that only 3 posttherapy follow-up (18)F-FDG PET/CT scans are funded for a tumor type per patient and any additional follow-up PET/CT scans will be funded at the discretion of the loc ... Full text Link to item Cite

Brain FDG PET and the diagnosis of dementia.

Journal Article AJR Am J Roentgenol · January 2015 OBJECTIVE: We review the role of brain FDG PET in the diagnosis of Alzheimer disease, frontotemporal dementia, dementia with Lewy bodies, and vascular dementia. Characteristic spatial patterns of brain metabolism on FDG PET can help differentiate various s ... Full text Link to item Cite

MR imaging and PET/CT in diagnosis and management of multiple myeloma.

Journal Article Radiographics · 2015 Multiple myeloma is a common hematologic malignancy among the elderly population. Although there have been many advances in treatment over the past few decades, the overall prognosis for the disease remains poor. Conventional radiography has long been the ... Full text Link to item Cite

ACR Appropriateness Criteria Dementia and Movement Disorders.

Journal Article J Am Coll Radiol · January 2015 Neurodegenerative disease, including dementia, extrapyramidal degeneration, and motor system degeneration, is a growing public health concern and is quickly becoming one of the top health care priorities of developed nations. The primary function of anatom ... Full text Link to item Cite

Methods and challenges in quantitative imaging biomarker development.

Journal Article Acad Radiol · January 2015 Academic radiology is poised to play an important role in the development and implementation of quantitative imaging (QI) tools. This article, drafted by the Association of University Radiologists Radiology Research Alliance Quantitative Imaging Task Force ... Full text Link to item Cite

Building for tomorrow today: opportunities and directions in radiology resident research.

Journal Article Acad Radiol · January 2015 RATIONALE AND OBJECTIVES: With rapid scientific and technological advancements in radiological research, there is renewed emphasis on promoting early research training to develop researchers who are capable of tackling the hypothesis-driven research that i ... Full text Link to item Cite

Clinical utility of quantitative imaging.

Journal Article Acad Radiol · January 2015 Quantitative imaging (QI) is increasingly applied in modern radiology practice, assisting in the clinical assessment of many patients and providing a source of biomarkers for a spectrum of diseases. QI is commonly used to inform patient diagnosis or progno ... Full text Link to item Cite

Liver standardized uptake value corrected for lean body mass at FDG PET/CT: effect of FDG uptake time.

Journal Article Clin Nucl Med · January 2015 OBJECTIVE: The objective of this study is to establish the magnitude change and interreader reliability of the liver standardized uptake value corrected for lean body mass (SULmean) in dual-time-point imaging at 1 and 2 hours and 1 and 4 hours. PATIENTS AN ... Full text Link to item Cite

Imaging modality utilization trends in patients with stage III-IV oropharyngeal squamous cell carcinoma.

Journal Article Am J Nucl Med Mol Imaging · 2015 The objective of this study is to establish the utilization trends of CT, MRI, and FDG-PET/CT for evaluation of oropharyngeal squamous cell carcinoma (OPSCC) patients. A total of 173 patients with newly diagnosed stage III or IV OPSCC between 2003 and 2009 ... Link to item Cite

Contrast-Induced Nephropathy: Comparative Effects of Different Contrast Media

Journal Article · 2015 ObjectivesTo evaluate the comparative effects of different types of contrast media with respect to the risk of developing contrast-induced nephropathy (CIN) by synthesizing the current literature.Data sourcesWe searched for original studi ... Cite

Perceived misinterpretation rates in oncologic 18F-FDG PET/CT studies: a survey of referring physicians.

Journal Article J Nucl Med · December 2014 UNLABELLED: Because only pathologic examination can confirm the presence or absence of malignant disease in cancer patients, a certain rate of misinterpretation in any kind of imaging study is inevitable. For the accuracy of interpretation to be improved, ... Full text Link to item Cite

FDG PET/CT in the management of colorectal and anal cancers.

Journal Article AJR Am J Roentgenol · November 2014 OBJECTIVE: CT remains the imaging modality of choice in the diagnosis of colorectal cancer (CRC) and anal cancer. However, advances in imaging have expanded the role of MRI and PET/CT. This article focuses on the evolving role of FDG PET/CT in the diagnosi ... Full text Link to item Cite

Brain PET in the diagnosis of Alzheimer's disease.

Journal Article Clin Nucl Med · October 2014 OBJECTIVES: The aim of this article was to review the current role of brain PET in the diagnosis of Alzheimer dementia. The characteristic patterns of glucose metabolism on brain FDG-PET can help in differentiating Alzheimer's disease from other causes of ... Full text Link to item Cite

Prognostic value of FDG PET metabolic tumor volume in human papillomavirus-positive stage III and IV oropharyngeal squamous cell carcinoma.

Journal Article AJR Am J Roentgenol · October 2014 OBJECTIVE: The purpose of this study was to establish the prognostic utility in human papillomavirus (HPV)-positive stage III and IV oropharyngeal squamous cell carcinoma (SCC) of the (18)F-FDG parameters maximal, mean, and peak standardized uptake value ( ... Full text Link to item Cite

Value of imaging in head and neck tumors.

Journal Article Surg Oncol Clin N Am · October 2014 In this review, the value of imaging in the management of head and neck tumors is summarized. The many diverse tumors of the head and neck are grouped for purposes of staging and treatment. The groupings of malignancies consist of sinonasal, nasopharynx, s ... Full text Link to item Cite

Head and neck PET/CT: therapy response interpretation criteria (Hopkins Criteria)-interreader reliability, accuracy, and survival outcomes.

Journal Article J Nucl Med · September 2014 UNLABELLED: There has been no established qualitative system of interpretation for therapy response assessment using PET/CT for head and neck cancers. The objective of this study was to validate the Hopkins interpretation system to assess therapy response ... Full text Link to item Cite

FDG PET/CT in the management of nasopharyngeal carcinoma.

Journal Article AJR Am J Roentgenol · August 2014 OBJECTIVE: FDG PET/CT has a growing role in the diagnosis and management of nasopharyngeal carcinoma (NPC). FDG PET has greater efficacy for N and M staging than other modalities, which enables the treating oncologists to select the appropriate mode of tre ... Full text Link to item Cite

FDG volumetric parameters and survival outcomes after definitive chemoradiotherapy in patients with recurrent head and neck squamous cell carcinoma.

Journal Article AJR Am J Roentgenol · August 2014 OBJECTIVE: The purpose of this study was to establish the predictive value of (18)F-FDG parameters for overall survival in biopsy-proven recurrent head and neck squamous cell cancer (HNSCC) patients after definitive chemoradiotherapy. MATERIALS AND METHODS ... Full text Link to item Cite

Follow-up or Surveillance (18)F-FDG PET/CT and Survival Outcome in Lung Cancer Patients.

Journal Article J Nucl Med · July 2014 UNLABELLED: The value of performing follow-up PET/CT imaging more than 6 mo after the conclusion of therapy-either as a routine practice or because of clinically suspected recurrence-is not well established. The purpose of this study was to evaluate the ad ... Full text Link to item Cite

PET/CT in the management of thyroid cancers.

Journal Article AJR Am J Roentgenol · June 2014 OBJECTIVE: Thyroid cancer is the most common endocrine cancer. This review evaluates the established use of (18)F-FDG PET/CT in papillary, follicular, Hürthle cell, anaplastic, and medullary thyroid cancers. The significance of incidental diffuse and focal ... Full text Link to item Cite

FDG PET metabolic tumor volume segmentation and pathologic volume of primary human solid tumors.

Journal Article AJR Am J Roentgenol · May 2014 OBJECTIVE: The purpose of this study was to establish the correlation and reliability among the pathologic tumor volume and gradient and fixed threshold segmentations of (18)F-FDG PET metabolic tumor volume of human solid tumors. MATERIALS AND METHODS: The ... Full text Link to item Cite

A prognostic volumetric threshold of gross tumor volume in head and neck cancer patients treated with radiotherapy.

Journal Article Am J Clin Oncol · April 2014 OBJECTIVES: To determine the prognostic utility of a volumetric threshold for gross tumor volume (GTV) of the primary and nodal disease when accounting for the TNM classification in head and neck cancer (HNC) patients treated with definitive radiotherapy ( ... Full text Link to item Cite

PET/CT imaging and human papilloma virus-positive oropharyngeal squamous cell cancer: evolving clinical imaging paradigm.

Journal Article J Nucl Med · March 2014 Human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinoma (OPSCC) represents an emerging disease that differs from HPV-negative OPSCC in natural history and prognosis. Contrast-enhanced PET/CT is essential to accurately stage the primary si ... Full text Link to item Cite

FDG PET/CT imaging of oropharyngeal squamous cell carcinoma: characteristics of human papillomavirus-positive and -negative tumors.

Journal Article Clin Nucl Med · March 2014 OBJECTIVE: The objective of this study was to assess differences in morphological and glycolytic characteristics of primary tumors and locoregional nodal disease between human papillomavirus (HPV)-positive and HPV-negative oropharyngeal head and neck squam ... Full text Link to item Cite

FDG-PET/CT in the evaluation of paraneoplastic neurologic syndromes

Journal Article Imaging in Medicine · February 1, 2014 Paraneoplastic neurologic syndromes (PNS) are a rare, heterogeneous group of complications associated with malignancy, unrelated to direct tumor invasion or metastasis, that may be immune-mediated. The aim of this article is to provide an overview of PNS a ... Full text Cite

Head and neck squamous cell cancer (stages III and IV) induction chemotherapy assessment: value of FDG volumetric imaging parameters.

Journal Article J Med Imaging Radiat Oncol · February 2014 INTRODUCTION: To evaluate whether the change in the metabolic tumour volume (MTV) or total lesion glycolysis (TLG) of the primary tumour, before and after induction chemotherapy, predicts outcome for patients with advanced head and neck squamous cell cance ... Full text Link to item Cite

Interreader agreement and variability of FDG PET volumetric parameters in human solid tumors.

Journal Article AJR Am J Roentgenol · February 2014 OBJECTIVE: The purpose of this article is to evaluate the interreader agreement and variability of two (18)F-FDG PET parameters, metabolic tumor volume and total lesion glycolysis, in human solid tumors. MATERIALS AND METHODS: One hundred eleven patients ( ... Full text Link to item Cite

Addition of 18F-FDG PET/CT to clinical assessment predicts overall survival in HNSCC: a retrospective analysis with follow-up for 12 years.

Journal Article J Nucl Med · December 2013 UNLABELLED: (18)F-FDG PET/CT is used in the follow-up of patients with head and neck squamous cell cancer (HNSCC). However, its impact on clinical decision making and patient outcome is not fully established. The objective of this study was to determine th ... Full text Link to item Cite

SPECT in malignant bone diseases

Chapter · December 1, 2013 Cite

Radiology research and medical students.

Journal Article Acad Radiol · December 2013 Fostering radiology research among medical students can enhance a student's interest and understanding of radiology and research. It increases the academic productivity of the mentor and the department. Radiology faculty and departments should actively see ... Full text Link to item Cite

Impact of concurrent diagnostic level CT with PET/CT on the utilization of stand-alone CT and MRI in the management of head and neck cancer patients.

Journal Article Clin Nucl Med · October 2013 PURPOSE OF THE REPORT: This study aims to determine if the expansion of a PET/CT service to include simultaneous contrast-enhanced CT with PET (PET/DCT) leads to a reduction of supplemental diagnostic CT (sCT) performed within a 6-month period centered aro ... Full text Link to item Cite

Dopamine Transporter SPECT Imaging in Parkinson Disease and Dementia.

Journal Article PET Clin · October 2013 The clinical diagnosis of Parkinson disease (PD) is difficult, as several other neurodegenerative and basal ganglia disorders have similar clinical presentations. Dopamine transporter single-photon emission computed tomography has been proposed as possible ... Full text Link to item Cite

Schwannoma in neurofibromatosis type 1: a pitfall for detecting malignancy by metabolic imaging.

Journal Article Skeletal Radiol · September 2013 Neurofibromatosis type 1 (NF1) is a neurocutaneous syndrome characterized by the development of multiple peripheral nerve sheath tumors, the majority of which are benign neurofibromas. However, malignant peripheral nerve sheath tumors (MPNSTs) occur with a ... Full text Link to item Cite

FDG PET/CT in the management of primary pleural tumors and pleural metastases.

Journal Article AJR Am J Roentgenol · August 2013 OBJECTIVE. FDG PET/CT is emerging as an important modality in the evaluation of pleural tumors. PET/CT has an established role in the diagnosis and staging and shows promise in therapy planning, therapy response assessment, and providing prognostic informa ... Full text Link to item Cite

The role of PET/CT in the management of cervical cancer.

Journal Article AJR Am J Roentgenol · August 2013 OBJECTIVE. Cervical cancer is the second most common malignancy in women worldwide and the third most common cause of cancer mortality in the United States. The aim of this article is to describe cervical cancer and outline the value of (18)F-FDG PET/CT in ... Full text Link to item Cite

Liver SULmean at FDG PET/CT: interreader agreement and impact of placement of volume of interest.

Journal Article Radiology · May 2013 PURPOSE: To evaluate how interreader agreement and the site of the volume of interest (VOI) affect the agreement and variability of liver mean standardized uptake value normalized to lean body mass (SUL(mean)) at fluorine 18 fluorodeoxyglucose (FDG) positr ... Full text Link to item Cite

Evolving role of FDG PET/CT in multiple myeloma imaging and management.

Journal Article AJR Am J Roentgenol · April 2013 OBJECTIVE: Multiple myeloma is the most common cause of primary malignancy in bones. Radiography has been the imaging reference standard for decades. However, the growing use of CT, MRI, and PET technology has led to earlier diagnosis of multiple myeloma, ... Full text Link to item Cite

PET/CT mediastinal and liver FDG uptake: effects of biological and procedural factors.

Journal Article J Med Imaging Radiat Oncol · April 2013 INTRODUCTION: To establish the effects of biological and procedural factors on mediastinal and liver [(18) F]-fluorodeoxyglucose (FDG) uptake in oncological FDG positron emission tomography/computed tomography (PET/CT). METHODS: This retrospective study in ... Full text Link to item Cite

PET-based primary tumor volumetric parameters and survival of patients with non-small cell lung carcinoma.

Journal Article AJR Am J Roentgenol · March 2013 OBJECTIVE: The purpose of the study was to assess metabolic tumor volume and total glycolytic activity of the primary tumor as prognostic parameters for outcome in patients with non-small cell lung carcinoma (NSCLC). MATERIALS AND METHODS: Thirty-nine pati ... Full text Link to item Cite

Positron emission tomography combined with diagnostic chest computed tomography enhances detection of regional recurrence after stereotactic body radiation therapy for early stage non-small cell lung cancer.

Conference J Thorac Cardiovasc Surg · March 2013 OBJECTIVE(S): Recommendations for surveillance after stereotactic body radiation therapy (SBRT) for early stage non-small cell lung cancer (NSCLC) are not well defined. Prospective studies evaluating the efficacy of SBRT have used interval posttreatment im ... Full text Link to item Cite

FDG-PET/CT imaging biomarkers in head and neck squamous cell carcinoma.

Journal Article Imaging Med · December 2012 This article discusses the value of 18F-fluoro-2-deoxyglucose PET/CT imaging biomarkers in head and neck squamous cell carcinoma. 18F-fluoro-2-deoxyglucose PET/CT is valuable at baseline staging, radiotherapy planning, therapy response assessment and in th ... Full text Link to item Cite

Intra-reader reliability of FDG PET volumetric tumor parameters: effects of primary tumor size and segmentation methods.

Journal Article Ann Nucl Med · November 2012 OBJECTIVE: To establish the effects of size and segmentation methods on intra-reader reliability of primary tumor metabolic tumor volume (MTV) and total glycolytic activity (TGA) in human solid tumors. METHODS: This is a retrospective study of 121 patients ... Full text Link to item Cite

PET/CT of cancer patients: part 2, deformable registration imaging before and after chemotherapy for radiation treatment planning in head and neck cancer.

Journal Article AJR Am J Roentgenol · November 2012 OBJECTIVE: The purpose of this perspective is to discuss the use of deformable registration as a tool for image fusion to integrate information from PET/CT scans obtained before and after chemotherapy to assist definition of radiation targets in the manage ... Full text Link to item Cite

PET/CT of cancer patients: part 1, pancreatic neoplasms.

Journal Article AJR Am J Roentgenol · November 2012 OBJECTIVE: Pancreatic cancer continues to have a poor prognosis despite impressive improvements in the outcomes of many other types of cancer, often because most pancreatic neoplasms are found to be unresectable at diagnosis. The purpose of this review is ... Full text Link to item Cite

Oncologic 18F-FDG PET/CT: referring physicians' point of view.

Journal Article J Nucl Med · October 2012 UNLABELLED: Oncologic (18)F-FDG PET/CT is rapidly gaining acceptance in clinical practice. However, the referring physician's attitude toward the usefulness of this diagnostic modality is unknown. This survey was undertaken to collect information regarding ... Full text Link to item Cite

Radiology quiz case 2. Docetaxel (Taxotere)-induced photosensitivity.

Journal Article Arch Otolaryngol Head Neck Surg · September 2012 Full text Link to item Cite

Superior prognostic utility of gross and metabolic tumor volume compared to standardized uptake value using PET/CT in head and neck squamous cell carcinoma patients treated with intensity-modulated radiotherapy.

Journal Article Ann Nucl Med · August 2012 OBJECTIVE: To compare the prognostic utility of the 2-[(18)F] fluoro-2-deoxy-D: -glucose (FDG) maximum standardized uptake value (SUV(max)), primary gross tumor volume (GTV), and FDG metabolic tumor volume (MTV) for disease control and survival in patients ... Full text Link to item Cite

The added value of 18F-FDG PET/CT for evaluation of patients with esthesioneuroblastoma.

Journal Article J Nucl Med · August 2012 UNLABELLED: The purpose of this study was to evaluate the clinical utility of (18)F-FDG PET/CT in esthesioneuroblastoma staging and restaging and quantify the additional benefit of PET/CT to conventional imaging. METHODS: A retrospective review was perform ... Full text Link to item Cite

FDG PET/CT of carcinoma showing thymus-like differentiation.

Journal Article Clin Nucl Med · July 2012 Carcinoma showing thymus-like differentiation is a malignant, extremely rare neoplasm that arises in the thyroid gland or neighboring neck soft tissue and closely resembles thymic carcinoma. Long-term survival is possible if the disease is diagnosed early ... Full text Link to item Cite

18F-FDG metabolic tumor volume and total glycolytic activity of oral cavity and oropharyngeal squamous cell cancer: adding value to clinical staging.

Journal Article J Nucl Med · May 2012 UNLABELLED: (18)F-FDG metabolic tumor volume (MTV) and total glycolytic activity (TGA) have been proposed as potential prognostic imaging markers for patient outcome in human solid tumors. The purpose of this study was to establish whether MTV and TGA add ... Full text Link to item Cite

FDG PET/CT interobserver agreement in head and neck cancer: FDG and CT measurements of the primary tumor site.

Journal Article Nucl Med Commun · March 2012 BACKGROUND: Interobserver agreement in measuring positron emission tomography (PET)/computed tomography (CT) parameters is critical for head and neck cancer management. The purpose of this study is to assess the interobserver agreement when measuring the s ... Full text Link to item Cite

Parotid gland tumors: preliminary data for the value of FDG PET/CT diagnostic parameters.

Journal Article AJR Am J Roentgenol · February 2012 OBJECTIVE: The purpose of this article is to establish (18)F-FDG metabolic imaging parameters to differentiate benign and malignant tumors of the parotid gland. MATERIALS AND METHODS: Forty-nine patients with increased FDG uptake in the parotid gland were ... Full text Link to item Cite

Deformable registration of preoperative PET/CT with postoperative radiation therapy planning CT in head and neck cancer.

Journal Article Radiographics · 2012 In intensity-modulated radiation therapy (IMRT), precise target delineation is important to avoid underdosing areas at risk for recurrence and overdosing adjacent normal tissue. In postoperative radiation therapy of patients with head and neck cancer (HNC) ... Full text Link to item Cite

Clinical correlation of previously undetected cancer-related incidental findings on CT planning scans for radiation therapy.

Journal Article AJR Am J Roentgenol · November 2011 OBJECTIVE: The purpose of our study was to determine the management and cancer outcome of incidental cancer-related findings reported on CT radiation treatment planning scans. MATERIALS AND METHODS: We conducted a retrospective review of CT planning scans ... Full text Link to item Cite

Use of 18F-FDG PET/CT as a predictive biomarker of outcome in patients with head-and-neck non-squamous cell carcinoma.

Journal Article AJR Am J Roentgenol · October 2011 OBJECTIVE: The purpose of this article is to establish whether pretreatment (18)F-FDG uptake predicts disease-free survival (DFS) and overall survival in patients with head-and-neck non-squamous cell carcinoma (SCC). MATERIALS AND METHODS: Eighteen patient ... Full text Link to item Cite

FDG PET/CT in patients with HIV.

Journal Article AJR Am J Roentgenol · August 2011 OBJECTIVE: This article will discuss the (18)F-FDG normal variant uptake and the role of FDG PET/CT in malignancies in HIV-infected patients, CNS manifestations of HIV, assessing fever of unknown origin in HIV patients, assessing response to highly active ... Full text Link to item Cite

Value of PET/CT in the management of liver metastases, part 1.

Journal Article AJR Am J Roentgenol · August 2011 OBJECTIVE: Metastasis is the most common (95%) of liver lesions. Early diagnosis and staging are the keys to treatment planning and prognosis. There is a consistent benefit to the use of PET/CT for detecting hepatic, local, and distant metastases from a va ... Full text Link to item Cite

Value of PET/CT in the management of primary hepatobiliary tumors, part 2.

Journal Article AJR Am J Roentgenol · August 2011 OBJECTIVE: Primary hepatobiliary malignancies consist of hepatocellular carcinoma, cholangiocarcinoma, and gallbladder cancer. Benign hepatic lesions include hepatic cysts, hemagiomas, adenomas, and focal nodular hyperplasias. The utility of PET/CT in imag ... Full text Link to item Cite

Implications of previously undetected incidental findings on 3D CT simulation scans for radiation therapy.

Journal Article Pract Radiat Oncol · 2011 PURPOSE: To determine the frequency of significant incidental findings on diagnostic quality simulation computed tomographic (CT) scans for radiotherapy planning. METHODS AND MATERIALS: An institutional review board--approved retrospective review of radiat ... Full text Link to item Cite

Ameloblastic carcinoma of the mandible with metastasis to the skull and lung: advanced imaging appearance including computed tomography, magnetic resonance imaging and positron emission tomography computed tomography.

Journal Article Dentomaxillofac Radiol · October 2010 Ameloblastic carcinoma is a very rare malignant odontogenic tumour with characteristic histopathological and clinical features, which requires aggressive surgical treatment and surveillance and, therefore, differs from ameloblastoma. Metastasis typically o ... Full text Link to item Cite

Squamous cell carcinoma of the palatine tonsils: FDG standardized uptake value ratio as a biomarker to differentiate tonsillar carcinoma from physiologic uptake.

Journal Article Radiology · May 2010 PURPOSE: To quantify fluorine 18 ((18)F) fluorodeoxyglucose (FDG) uptake in the palatine tonsils to identify a sensitive and specific metric for distinguishing physiologic asymmetric uptake from squamous cell carcinoma (SCC). MATERIALS AND METHODS: This HI ... Full text Link to item Cite

Fluorodeoxyglucose-positron-emission tomography imaging of head and neck squamous cell cancer.

Journal Article AJNR Am J Neuroradiol · April 2010 The hybrid technique of PET/CT has significantly impacted the imaging and management of HNSCC since its introduction in 2001 and has become the technique of choice for imaging of this cancer. Diagnostic FDG-PET/CT is useful for identification of an unknown ... Full text Link to item Cite

Brachial plexus contouring with CT and MR imaging in radiation therapy planning for head and neck cancer.

Journal Article Radiographics · 2010 With the increasing use of intensity-modulated radiation therapy (IMRT) for the treatment of head and neck cancer, radiation oncologists are expected to have an in-depth knowledge of the computed tomographic (CT) and magnetic resonance (MR) imaging anatomy ... Full text Link to item Cite

The Geneva prognostic score and mortality in patients diagnosed with pulmonary embolism by CT pulmonary angiogram.

Journal Article J Med Imaging Radiat Oncol · August 2009 This study prospectively evaluates whether a previously established adverse outcome score (the Geneva prognostic score) predicts 3 and 12-month overall mortality among the patients diagnosed with pulmonary embolism (PE) by a CT pulmonary angiogram (CTPA). ... Full text Link to item Cite

Utility of integrated computed tomography-positron emission tomography for selection of operable malignant pleural mesothelioma.

Journal Article Clin Lung Cancer · July 2009 BACKGROUND: Malignant pleural mesothelioma (MPM) is a primary malignancy characterized by local invasion of the pleura and metastasis. Despite advances in computed tomography (CT) and magnetic resonance imaging (MRI), accurately staging patients remains ch ... Full text Link to item Cite

18F-fluoro-2-deoxy-D-glucose positron emission tomography and positron emission tomography/computed tomography imaging of malignant pleural mesothelioma.

Journal Article J Med Imaging Radiat Oncol · April 2009 Malignant pleural mesothelioma (MPM) is the most common primary pleural tumor and its incidence is rising. Its diagnosis, staging and response assessment are challenging for imaging. Integrated positron emission tomography (PET)/CT increases the accuracy o ... Full text Link to item Cite

Occult malignancy in patients with suspected paraneoplastic neurologic syndromes: value of positron emission tomography in diagnosis.

Journal Article Mayo Clin Proc · August 2008 OBJECTIVE: To determine the value of positron emission tomography (PET) in diagnosing occult malignancies in patients with paraneoplastic neurologic syndromes (PNSs) at Mayo Clinic's site in Rochester, MN. PATIENTS AND METHODS: We retrospectively reviewed ... Full text Link to item Cite

F-18 FDG PET/CT imaging of submandibular gland oncocytoma.

Journal Article Clin Nucl Med · July 2008 F-18 FDG PET/CT is used to evaluate head and neck malignancies, including salivary gland tumors. We describe the FDG PET/CT features of a submandibular gland oncocytoma. An 85-year-old patient with small cell cancer of the lung and a history of squamous ce ... Full text Link to item Cite

Pulmonary embolism outcome: a prospective evaluation of CT pulmonary angiographic clot burden score and ECG score.

Journal Article AJR Am J Roentgenol · June 2008 OBJECTIVE: The purpose of this study was to establish whether a correlation exists between the CT pulmonary angiographic clot burden score, the ECG score at diagnosis, and the 12-month mortality rate among patients diagnosed with pulmonary embolism. SUBJEC ... Full text Link to item Cite

Development of an instrument to measure the clinical learning environment in diagnostic radiology.

Journal Article J Med Imaging Radiat Oncol · June 2008 A clinical learning environment survey instrument was developed that provided insights into diagnostic radiology trainees' perceptions of the culture and context of the hospital-based training programme. The survey was completed by trainees allocated to 37 ... Full text Link to item Cite

Bisphosphonate induced osteonecrosis of the mandible

Journal Article European Journal of Radiology Extra · April 1, 2008 Bisphosphonate-associated osteonecrosis of the mandible has been recently described. Since the diagnosis is confirmed by imaging rather than biopsy and treatment response is monitored by imaging, radiologists need to know this new entity. We present a case ... Full text Cite

The value of [(18)F]fluorodeoxyglucose positron emission tomography/computed tomography in extranodal natural killer/T-cell lymphoma.

Journal Article Clin Lymphoma Myeloma · April 2008 PURPOSE: To our knowledge, there are no published data pertinent to the use of [(18F)]fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) in patients with natural killer (NK)/T-cell lymphoma. The purpose of this study was t ... Full text Link to item Cite

18F-FDG PET/CT in primary central nervous system lymphoma in HIV-negative patients.

Journal Article Nucl Med Commun · November 2007 OBJECTIVE: To determine the value of F-FDG PET/CT in the different manifestations of primary central nervous system lymphoma (PCNSL) in HIV-negative patients. METHODS: All PCNSL and HIV-negative patients referred for PET/CT in our institution from July 200 ... Full text Link to item Cite

Squamous Cell Carcinoma: Restaging and Response to Therapy.

Journal Article PET Clin · October 2007 This article describes the use of 18F-fluorodeoxyglucose PET in patients who have head and neck cancer for assessment of therapy response, detection of locoregional recurrence and distant metastasis, and surveillance. ... Full text Link to item Cite

Withholding anticoagulation after a negative computed tomography pulmonary angiogram as a stand-alone imaging investigation: a prospective management study.

Journal Article Intern Med J · September 2007 BACKGROUND: Accurate diagnosis of pulmonary embolism (PE) is essential and it is not clear whether a computed tomography pulmonary angiogram (CTPA) could be used as a stand-alone imaging investigation. The aim of the study was to test the accuracy of the c ... Full text Link to item Cite

Medical student radiology teaching in Australia and New Zealand.

Journal Article Australas Radiol · August 2007 This study, involving 19 centres, establishes the status of medical student radiology teaching in Australia and New Zealand. It aims to document the academic and clinical staff profile involved in teaching, to indicate the methods of instructions used, to ... Full text Link to item Cite

Magnetic resonance imaging of ankle tendons and ligaments: part I - anatomy.

Journal Article Australas Radiol · August 2007 Magnetic resonance imaging is an excellent technique for imaging the tendons and the ligaments of the ankle. Owing to the advantage of detailed demonstration of soft-tissue structures and capability for multiplanar demonstration of the ankle ligaments and ... Full text Link to item Cite

Hibernoma: 18F FDG PET/CT imaging.

Journal Article J Thorac Oncol · June 2007 The patient was a 40-year-old woman who was diagnosed with a malignant melanoma of the left posterior thigh. Follow-up positron emission tomography (PET)/computed tomography (CT) examination revealed an intensely FDG-avid lesion that predominantly containe ... Full text Link to item Cite

Clinical significance of diffusely increased 18F-FDG uptake in the thyroid gland.

Journal Article J Nucl Med · June 2007 UNLABELLED: Our purpose was to determine the clinical significance of diffusely increased (18)F-FDG uptake in the thyroid gland as an incidental finding on PET/CT. METHODS: All patients who were found to have diffuse thyroid uptake on (18)F-FDG PET/CT in o ... Full text Link to item Cite

Contribution of F-18 FDG PET-CT in the detection of systemic spread of primary central nervous system lymphoma.

Journal Article Clin Nucl Med · April 2007 PURPOSE: Primary central nervous system lymphoma (PCNSL) accounts for approximately 3% of all primary brain tumors and 1% of all non-Hodgkin lymphomas. Detection of systemic spread of PCNSL, although rare (4%), is very important since therapy is usually mo ... Full text Link to item Cite

Radiology teaching: essentials of a quality teaching programme.

Journal Article Australas Radiol · February 2007 Medical student teaching is an important component of radiology education. Despite the practice of radiology undergoing significant changes during the last two or three decades, the importance of radiology has not translated fully into medical school curri ... Full text Link to item Cite

[18F]Fluoro-L-dopa PET/CT in congenital hyperinsulinism.

Journal Article J Comput Assist Tomogr · 2007 Congenital hyperinsulinism can be divided into diffuse or focal form. The treatment and outcome depend on distinguishing between the 2 forms. Pancreatic venous sampling was the only method available to localize the insulin secretion. [F]Fluoro-levodopa, 3, ... Full text Link to item Cite

Focal F-18 fluoro-deoxy-glucose accumulation in the lung parenchyma in the absence of CT abnormality in PET/CT.

Journal Article J Comput Assist Tomogr · 2007 OBJECTIVE: To demonstrate 3 cases of artifactual focal F-18 fluoro-deoxy-glucose accumulation in the lung parenchyma in the absence of any computed tomographic (CT) abnormality. MATERIALS AND METHODS: Three patients were examined: a 30-year-old man who had ... Full text Link to item Cite

Diagnosis of lower limb deep venous thrombosis in emergency department patients: performance of Hamilton and modified Wells scores.

Journal Article Ann Emerg Med · December 2006 STUDY OBJECTIVE: We validate and compare the Hamilton score for assessment of lower limb deep venous thrombosis with the modified Wells score. METHODS: Consecutive patients presenting to the emergency department of a tertiary center for suspected lower lim ... Full text Link to item Cite

RSNA Clinical Trials Methodology Workshop.

Journal Article Radiology · December 2006 Full text Link to item Cite

Radiology curriculum for medical students: clinicians' perspectives.

Journal Article Australas Radiol · October 2006 This study was conducted to establish clinicians' perspectives of a set of radiology curriculum topics for medical student teaching, which were held to be important by radiologists. A questionnaire was sent to clinicians in all specialties. Forty-six clini ... Full text Link to item Cite

Pulmonary embolism: accuracy and safety of a negative CT pulmonary angiogram and value of a negative D-dimer assay to exclude CT pulmonary angiogram-detectable pulmonary embolism.

Conference Australas Radiol · October 2006 This is a retrospective study to determine the accuracy and safety of a negative CT pulmonary angiogram (CTPA) based on clinical outcome and to determine the usefulness of a negative D-dimer assay before CTPA. A total of 483 patients with a negative CTPA s ... Full text Link to item Cite

Problem-based learning: concept, theories, effectiveness and application to radiology teaching.

Journal Article Australas Radiol · August 2006 Australian and New Zealand medical schools are partly or entirely incorporating problem-based learning (PBL) in their medical school curricula. As this change moves forwards and gathers momentum, radiologists are called upon to facilitate or to contribute ... Full text Link to item Cite

Radiology curriculum topics for medical students: students' perspectives.

Journal Article Acad Radiol · July 2006 RATIONALE AND OBJECTIVE: We sought to establish medical students' perspectives of a set of curriculum topics for radiology teaching. MATERIALS AND METHODS: A multicenter study was conducted in New Zealand. A modified Delphi method was adopted. Students enr ... Full text Link to item Cite

Computed tomography pulmonary angiogram diagnosis of pulmonary embolism.

Journal Article Australas Radiol · June 2006 Over the last decade, contrast-enhanced spiral CT has been established as a non-invasive alternative to catheter angiography and is now regarded as the first-line imaging investigation for the diagnosis of pulmonary embolism (PE). The reported sensitivitie ... Full text Link to item Cite

Vertebroplasty - a new treatment for vertebral compression fractures.

Journal Article Aust Fam Physician · May 2006 BACKGROUND: The lifetime risk of a vertebral body compression fracture is 16% for women and 5% for men. Vertebroplastyn involves the injection of artificial bone cement and an opacifier into the inter-trabecular marrow space of the fractured vertebra. OBJE ... Link to item Cite

Does an immunochromatographic D-dimer exclude acute lower limb deep venous thrombosis?

Journal Article Emerg Med Australas · 2006 BACKGROUND: A pre-test probability score and D-dimer may reduce the need for ultrasound examinations for excluding lower limb deep venous thrombosis (DVT). OBJECTIVE: To establish the accuracy of an immunochromatographic D-dimer assay called 'Simplify' for ... Full text Link to item Cite

Importance of pretest probability score and D-dimer assay before sonography for lower limb deep venous thrombosis.

Journal Article AJR Am J Roentgenol · January 2006 OBJECTIVE: The purpose of our study was to develop and validate a clinical score (the Hamilton score) for the assessment of lower limb deep venous thrombosis (DVT) and to determine the usefulness of this score and a D-dimer assay before a complete lower li ... Full text Link to item Cite

Response to editorial - 'Teaching imaging to medical students: Strategies and expectations' [5]

Journal Article New Zealand Medical Journal · November 25, 2005 Cite

Magnetic resonance and oncology imaging

Journal Article Cancer Forum · November 1, 2005 Magnetic resonance imaging is usefully employed on its own or with complementary technologies to evaluate stage and other characteristics for a range of specific tumour types. These include tumours of the central nervous system, head and neck, breast, pros ... Cite

Radiology knowledge in new medical graduates in New Zealand.

Journal Article N Z Med J · October 28, 2005 AIMS: To establish the level of knowledge of new medical graduates in New Zealand about common radiological investigations and to assess their ability to request most appropriate, cost-effective radiological investigations for common clinical scenarios. ME ... Link to item Cite

Deep venous thrombosis: withholding anticoagulation therapy after negative complete lower limb US findings.

Journal Article Radiology · October 2005 PURPOSE: To establish the safety of withholding anticoagulation therapy after negative findings at a complete lower limb ultrasonographic (US) examination of the symptomatic leg for suspected deep venous thrombosis (DVT). MATERIALS AND METHODS: Regional et ... Full text Link to item Cite

ACRIN fellowship 2004: personal perspectives.

Journal Article J Am Coll Radiol · March 2005 Full text Link to item Cite

Problem-based learning and medical student radiology teaching.

Journal Article Australas Radiol · September 2004 The present study describes some practical advantages and disadvantages of problem-based learning (PBL), and makes suggestions to improve PBL radiology teaching of medical students. ... Full text Link to item Cite

Transverse sinus septum: a new aetiology of idiopathic intracranial hypertension?

Journal Article Australas Radiol · June 2004 A venographic cryptic stenosis at the junction of middle and lateral third of the transverse sinus has been observed in patients suffering from idiopathic intracranial hypertension. After reviewing the anatomical and embryological literature of the transve ... Full text Link to item Cite

Medical student radiology training: what are the objectives for contemporary medical practice?

Journal Article Acad Radiol · March 2003 RATIONALE AND OBJECTIVES: The authors attempt to provide a set of objectives for medical student training in radiology for contemporary medical practice. MATERIALS AND METHODS: A questionnaire containing a list of educational objectives was sent to 32 radi ... Full text Link to item Cite

High-pressure water injection injury: emergency presentation and management.

Journal Article Emerg Med (Fremantle) · September 2002 Presentations of high-pressure water blaster injuries to the emergency department are varied. Though these injuries are sometimes described as a 'benign variant' of high-pressure injection injuries, external appearances can be deceptive. These injuries can ... Full text Link to item Cite

Major histocompatibility complex class I-restricted cross-presentation is biased towards high dose antigens and those released during cellular destruction.

Journal Article J Exp Med · July 20, 1998 Naive T cells recirculate mainly within the secondary lymphoid compartment, but once activated they can enter peripheral tissues and perform effector functions. To activate naive T cells, foreign antigens must traffic from the site of infection to the drai ... Full text Link to item Cite