Scholars@Duke
Afshin Farzaneh-Far

Afshin Farzaneh-Far

Assistant Consulting Professor in the Department of Medicine
Medicine, Cardiology
aff25@hotmail.com
Duke Box 3934, Durham, NC 27710
DCMRC, 200 Trent Drive Duke So, Orange Zone Room# 4229, Durham, NC 27710
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Selected Publications

Tissue-Based Predictors of Impaired Right Ventricular Strain in Coronary Artery Disease: A Multicenter Stress Perfusion Study.

Journal Article Circ Cardiovasc Imaging · August 2024 BACKGROUND: Right ventricular (RV) dysfunction is known to impact prognosis, but its determinants in coronary artery disease are poorly understood. Stress cardiac magnetic resonance (CMR) has been used to assess ischemia and infarction in relation to the l ... Full text Link to item Cite

Association of Adverse Clinical Outcomes With Peri-Infarct Ischemia Detected by Stress Cardiac Magnetic Imaging.

Journal Article J Am Coll Cardiol · July 30, 2024 BACKGROUND: Early invasive revascularization guided by moderate to severe ischemia did not improve outcomes over medical therapy alone, underlying the need to identify high-risk patients for a more effective invasive referral. CMR could determine the myoca ... Full text Link to item Cite

The Society for Cardiovascular Magnetic Resonance Registry at 150,000.

Journal Article J Cardiovasc Magn Reson · July 4, 2024 BACKGROUND: Cardiovascular magnetic resonance (CMR) is increasingly utilized to evaluate expanding cardiovascular conditions. The Society for Cardiovascular Magnetic Resonance (SCMR) Registry is a central repository for real-world clinical data to support ... Full text Link to item Cite

Sex-Specific Stress Perfusion Cardiac Magnetic Resonance Imaging in Suspected Ischemic Heart Disease: Insights From SPINS Retrospective Registry.

Journal Article JACC Cardiovasc Imaging · June 2023 BACKGROUND: Cardiovascular disease (CVD) remains the leading cause of mortality in women, but current noninvasive cardiac imaging techniques have sex-specific limitations. OBJECTIVES: In this study, the authors sought to investigate the effect of sex on th ... Full text Link to item Cite

Myocardial Contractile Mechanics in Ischemic Mitral Regurgitation: Multicenter Data Using Stress Perfusion Cardiovascular Magnetic Resonance.

Journal Article JACC Cardiovasc Imaging · July 2022 BACKGROUND: Left ventricular (LV) ischemia has been variably associated with functional mitral regurgitation (FMR). Determinants of FMR in patients with ischemia are poorly understood. OBJECTIVES: This study sought to test whether contractile mechanics in ... Full text Link to item Cite

ACR Appropriateness Criteria® Dyspnea-Suspected Cardiac Origin (Ischemia Already Excluded): 2021 Update.

Journal Article J Am Coll Radiol · May 2022 Dyspnea is the symptom of perceived breathing discomfort and is commonly encountered in a variety of clinical settings. Cardiac etiologies of dyspnea are an important consideration; among these, valvular heart disease (Variant 1), arrhythmia (Variant 2), a ... Full text Link to item Cite

Global Longitudinal Strain to Predict Respiratory Failure and Death in Patients Admitted for COVID-19-Related Disease.

Journal Article Am J Cardiol · February 15, 2022 Evidence of the involvement of the cardiovascular system in patients with COVID-19 is increasing. The evaluation of the subclinical cardiac involvement is crucial for risk stratification at admission, and left ventricular global longitudinal strain (LVGLS) ... Full text Link to item Cite

Prognostic Value of Stress Cardiac Magnetic Resonance in Patients With Known Coronary Artery Disease.

Journal Article JACC Cardiovasc Imaging · January 2022 OBJECTIVES: This study sought to determine whether stress cardiac magnetic resonance (CMR) provides clinically relevant risk reclassification in patients with known coronary artery disease (CAD) in a multicenter setting in the United States. BACKGROUND: De ... Full text Link to item Cite

Left ventricular thrombus on cardiovascular magnetic resonance imaging in non-ischaemic cardiomyopathy.

Journal Article Eur Heart J Cardiovasc Imaging · November 22, 2021 AIMS: Case reports have described left ventricular (LV) thrombus in patients with non-ischaemic cardiomyopathy (NICM). We aimed to systematically study the characteristics, predictors, and outcomes of LV thrombus in NICM. METHODS AND RESULTS: Forty-eight p ... Full text Link to item Cite

Visualization of Human Aortic Valve Dynamics Using Magnetic Resonance Imaging with Sub-Millisecond Temporal Resolution.

Journal Article J Magn Reson Imaging · October 2021 BACKGROUND: Visualization of aortic valve dynamics is important in diagnosing valvular diseases but is challenging to perform with magnetic resonance imaging (MRI) due to the limited temporal resolution. PURPOSE: To develop an MRI technique with sub-millis ... Full text Link to item Cite

Prognostic Value of Feature-Tracking Right Ventricular Longitudinal Strain in Severe Functional Tricuspid Regurgitation: A Multicenter Study.

Journal Article JACC Cardiovasc Imaging · August 2021 OBJECTIVES: This study sought to evaluate the prognostic value of cardiac magnetic resonance (CMR) feature-tracking-derived right ventricular (RV) free wall longitudinal strain (RVFWLS) in a large multicenter population of patients with severe functional t ... Full text Link to item Cite

Stress CMR in patients with obesity: insights from the Stress CMR Perfusion Imaging in the United States (SPINS) registry.

Journal Article Eur Heart J Cardiovasc Imaging · April 28, 2021 AIMS: Non-invasive assessment and risk stratification of coronary artery disease in patients with large body habitus is challenging. We aim to examine whether body mass index (BMI) modifies the prognostic value and diagnostic utility of stress cardiac magn ... Full text Link to item Cite

Ischemia-Mediated Dysfunction in Subpapillary Myocardium as a Marker of Functional Mitral Regurgitation.

Journal Article JACC Cardiovasc Imaging · April 2021 OBJECTIVES: The goal of this study was to test whether ischemia-mediated contractile dysfunction underlying the mitral valve affects functional mitral regurgitation (FMR) and the prognostic impact of FMR. BACKGROUND: FMR results from left ventricular (LV) ... Full text Link to item Cite

Evaluation of Stress Cardiac Magnetic Resonance Imaging in Risk Reclassification of Patients With Suspected Coronary Artery Disease.

Journal Article JAMA Cardiol · December 1, 2020 IMPORTANCE: The role of stress cardiac magnetic resonance (CMR) imaging in clinical decision-making by reclassification of risk across American College of Cardiology/American Heart Association guideline-recommended categories has not been established. OBJE ... Full text Link to item Cite

Tissue-Based Predictors of Impaired Right Ventricular Strain in Coronary Artery Disease: A Multicenter Stress Perfusion Study.

Journal Article Circ Cardiovasc Imaging · August 2024 BACKGROUND: Right ventricular (RV) dysfunction is known to impact prognosis, but its determinants in coronary artery disease are poorly understood. Stress cardiac magnetic resonance (CMR) has been used to assess ischemia and infarction in relation to the l ... Full text Link to item Cite

Association of Adverse Clinical Outcomes With Peri-Infarct Ischemia Detected by Stress Cardiac Magnetic Imaging.

Journal Article J Am Coll Cardiol · July 30, 2024 BACKGROUND: Early invasive revascularization guided by moderate to severe ischemia did not improve outcomes over medical therapy alone, underlying the need to identify high-risk patients for a more effective invasive referral. CMR could determine the myoca ... Full text Link to item Cite

The Society for Cardiovascular Magnetic Resonance Registry at 150,000.

Journal Article J Cardiovasc Magn Reson · July 4, 2024 BACKGROUND: Cardiovascular magnetic resonance (CMR) is increasingly utilized to evaluate expanding cardiovascular conditions. The Society for Cardiovascular Magnetic Resonance (SCMR) Registry is a central repository for real-world clinical data to support ... Full text Link to item Cite

Sex-Specific Stress Perfusion Cardiac Magnetic Resonance Imaging in Suspected Ischemic Heart Disease: Insights From SPINS Retrospective Registry.

Journal Article JACC Cardiovasc Imaging · June 2023 BACKGROUND: Cardiovascular disease (CVD) remains the leading cause of mortality in women, but current noninvasive cardiac imaging techniques have sex-specific limitations. OBJECTIVES: In this study, the authors sought to investigate the effect of sex on th ... Full text Link to item Cite

Myocardial Contractile Mechanics in Ischemic Mitral Regurgitation: Multicenter Data Using Stress Perfusion Cardiovascular Magnetic Resonance.

Journal Article JACC Cardiovasc Imaging · July 2022 BACKGROUND: Left ventricular (LV) ischemia has been variably associated with functional mitral regurgitation (FMR). Determinants of FMR in patients with ischemia are poorly understood. OBJECTIVES: This study sought to test whether contractile mechanics in ... Full text Link to item Cite

ACR Appropriateness Criteria® Dyspnea-Suspected Cardiac Origin (Ischemia Already Excluded): 2021 Update.

Journal Article J Am Coll Radiol · May 2022 Dyspnea is the symptom of perceived breathing discomfort and is commonly encountered in a variety of clinical settings. Cardiac etiologies of dyspnea are an important consideration; among these, valvular heart disease (Variant 1), arrhythmia (Variant 2), a ... Full text Link to item Cite

Global Longitudinal Strain to Predict Respiratory Failure and Death in Patients Admitted for COVID-19-Related Disease.

Journal Article Am J Cardiol · February 15, 2022 Evidence of the involvement of the cardiovascular system in patients with COVID-19 is increasing. The evaluation of the subclinical cardiac involvement is crucial for risk stratification at admission, and left ventricular global longitudinal strain (LVGLS) ... Full text Link to item Cite

Prognostic Value of Stress Cardiac Magnetic Resonance in Patients With Known Coronary Artery Disease.

Journal Article JACC Cardiovasc Imaging · January 2022 OBJECTIVES: This study sought to determine whether stress cardiac magnetic resonance (CMR) provides clinically relevant risk reclassification in patients with known coronary artery disease (CAD) in a multicenter setting in the United States. BACKGROUND: De ... Full text Link to item Cite

Left ventricular thrombus on cardiovascular magnetic resonance imaging in non-ischaemic cardiomyopathy.

Journal Article Eur Heart J Cardiovasc Imaging · November 22, 2021 AIMS: Case reports have described left ventricular (LV) thrombus in patients with non-ischaemic cardiomyopathy (NICM). We aimed to systematically study the characteristics, predictors, and outcomes of LV thrombus in NICM. METHODS AND RESULTS: Forty-eight p ... Full text Link to item Cite

Visualization of Human Aortic Valve Dynamics Using Magnetic Resonance Imaging with Sub-Millisecond Temporal Resolution.

Journal Article J Magn Reson Imaging · October 2021 BACKGROUND: Visualization of aortic valve dynamics is important in diagnosing valvular diseases but is challenging to perform with magnetic resonance imaging (MRI) due to the limited temporal resolution. PURPOSE: To develop an MRI technique with sub-millis ... Full text Link to item Cite

Prognostic Value of Feature-Tracking Right Ventricular Longitudinal Strain in Severe Functional Tricuspid Regurgitation: A Multicenter Study.

Journal Article JACC Cardiovasc Imaging · August 2021 OBJECTIVES: This study sought to evaluate the prognostic value of cardiac magnetic resonance (CMR) feature-tracking-derived right ventricular (RV) free wall longitudinal strain (RVFWLS) in a large multicenter population of patients with severe functional t ... Full text Link to item Cite

Stress CMR in patients with obesity: insights from the Stress CMR Perfusion Imaging in the United States (SPINS) registry.

Journal Article Eur Heart J Cardiovasc Imaging · April 28, 2021 AIMS: Non-invasive assessment and risk stratification of coronary artery disease in patients with large body habitus is challenging. We aim to examine whether body mass index (BMI) modifies the prognostic value and diagnostic utility of stress cardiac magn ... Full text Link to item Cite

Ischemia-Mediated Dysfunction in Subpapillary Myocardium as a Marker of Functional Mitral Regurgitation.

Journal Article JACC Cardiovasc Imaging · April 2021 OBJECTIVES: The goal of this study was to test whether ischemia-mediated contractile dysfunction underlying the mitral valve affects functional mitral regurgitation (FMR) and the prognostic impact of FMR. BACKGROUND: FMR results from left ventricular (LV) ... Full text Link to item Cite

Evaluation of Stress Cardiac Magnetic Resonance Imaging in Risk Reclassification of Patients With Suspected Coronary Artery Disease.

Journal Article JAMA Cardiol · December 1, 2020 IMPORTANCE: The role of stress cardiac magnetic resonance (CMR) imaging in clinical decision-making by reclassification of risk across American College of Cardiology/American Heart Association guideline-recommended categories has not been established. OBJE ... Full text Link to item Cite

Red flags in cardiac amyloidosis.

Journal Article Eur J Prev Cardiol · November 2020 Full text Link to item Cite

Prognostic Value of Stress CMR Perfusion Imaging in Patients With Reduced Left Ventricular Function.

Journal Article JACC Cardiovasc Imaging · October 2020 OBJECTIVES: The aim of this study was to investigate the prognostic value of stress cardiac magnetic resonance imaging (CMR) in patients with reduced left ventricular (LV) systolic function. BACKGROUND: Patients with ischemic cardiomyopathy are at risk fro ... Full text Link to item Cite

Cardiac Magnetic Resonance Feature Tracking Global Longitudinal Strain and Prognosis After Heart Transplantation.

Journal Article JACC Cardiovasc Imaging · September 2020 OBJECTIVES: This study determined the long-term prognostic significance of GLS assessed using CMR-FT in a large cohort of heart transplant recipients. BACKGROUND: In heart transplant recipients, global longitudinal strain (GLS) assessed using echocardiogra ... Full text Link to item Cite

Imaging and Impact of Myocardial Strain in Myocarditis.

Journal Article JACC Cardiovasc Imaging · September 2020 Full text Link to item Cite

Imaging of Clinically Unrecognized Myocardial Fibrosis in Patients With Suspected Coronary Artery Disease.

Journal Article J Am Coll Cardiol · August 25, 2020 BACKGROUND: Stress cardiac magnetic resonance (CMR) provides accurate assessment of both myocardial infarction (MI) and ischemia. OBJECTIVES: This study aimed to evaluate the incremental prognostic value of unrecognized myocardial infarction (UMI), detecte ... Full text Link to item Cite

Cost-Effectiveness Analysis of Stress Cardiovascular Magnetic Resonance Imaging for Stable Chest Pain Syndromes.

Journal Article JACC Cardiovasc Imaging · July 2020 OBJECTIVES: The aim of this study was to compare, using results from the multicenter SPINS (Stress CMR Perfusion Imaging in the United States) study, the incremental cost-effectiveness of a stress cardiovascular magnetic resonance (CMR)-first strategy agai ... Full text Link to item Cite

Right Ventricular Abnormalities on Cardiovascular Magnetic Resonance Imaging in Patients With Sarcoidosis.

Journal Article JACC Cardiovasc Imaging · June 2020 OBJECTIVES: This study aimed to determine the prevalence on cardiac magnetic resonance (CMR) of right ventricular (RV) systolic dysfunction and RV late gadolinium enhancement (LGE), their determinants, and their influences on long-term adverse outcomes in ... Full text Link to item Cite

Feature-Tracking Global Longitudinal Strain Predicts Mortality in Patients With Preserved Ejection Fraction: A Multicenter Study.

Journal Article JACC Cardiovasc Imaging · April 2020 OBJECTIVES: The goal of this study was to evaluate the prognostic value of global longitudinal strain (GLS) derived from cardiac magnetic resonance (CMR) feature-tracking in a large multicenter population of patients with preserved ejection fraction. BACKG ... Full text Link to item Cite

MITRAL ANNULAR DISJUNCTION: WHEN YOU HAVE MAD, GET GAD(OLINIUM)

Conference JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY · March 24, 2020 Link to item Cite

Prognostic Implications of Blunted Feature-Tracking Global Longitudinal Strain During Vasodilator Cardiovascular Magnetic Resonance Stress Imaging.

Journal Article JACC Cardiovasc Imaging · January 2020 OBJECTIVES: The purpose of this study was to determine the prognostic value of feature-tracking global longitudinal strain (GLS) measured during vasodilator stress cardiac magnetic resonance (CMR) imaging. BACKGROUND: Prior studies have suggested that blun ... Full text Link to item Cite

Long-Term Embolic Outcomes After Detection of Left Ventricular Thrombus by Late Gadolinium Enhancement Cardiovascular Magnetic Resonance Imaging: A Matched Cohort Study.

Conference Circ Cardiovasc Imaging · November 2019 BACKGROUND: Late gadolinium enhancement (LGE) cardiovascular magnetic resonance (CMR) imaging is more sensitive than echocardiography for the detection of intracardiac thrombus because of its unique ability to identify thrombus based on tissue characterist ... Full text Link to item Cite

Cardiac Magnetic Resonance Stress Perfusion Imaging for Evaluation of Patients With Chest Pain.

Journal Article J Am Coll Cardiol · October 8, 2019 BACKGROUND: Stress cardiac magnetic resonance imaging (CMR) has demonstrated excellent diagnostic and prognostic value in single-center studies. OBJECTIVES: This study sought to investigate the prognostic value of stress CMR and downstream costs from subse ... Full text Link to item Cite

Myocardial Fibrosis and Prognosis in Heart Transplant Recipients.

Journal Article Circ Cardiovasc Imaging · October 2019 BACKGROUND: Myocardial fibrosis is a well-described histopathologic feature in heart transplant recipients. Whether myocardial fibrosis in heart transplant recipients is independently associated with clinical outcomes is unclear. We sought to determine whe ... Full text Link to item Cite

Prognostic Implications of Mitral Annular Plane Systolic Excursion in Patients with Hypertension and a Clinical Indication for Cardiac Magnetic Resonance Imaging: A Multicenter Study.

Journal Article JACC Cardiovasc Imaging · September 2019 OBJECTIVES: This study sought to evaluate the prognostic value of cardiac magnetic resonance (CMR)-derived mitral annular plane systolic excursion (MAPSE) in a large multicenter population of patients with hypertension. BACKGROUND: In patients with hyperte ... Full text Link to item Cite

Assessment of the 2017 AHA/ACC/HRS Guideline Recommendations for Implantable Cardioverter-Defibrillator Implantation in Cardiac Sarcoidosis.

Journal Article Circ Arrhythm Electrophysiol · September 2019 BACKGROUND: Implantable cardioverter-defibrillators are used to prevent sudden cardiac death in patients with cardiac sarcoidosis. The most recent recommendations for implantable cardioverter-defibrillator implantation in these patients are in the 2017 Ame ... Full text Link to item Cite

Global Coronary Flow Reserve Measured During Stress Cardiac Magnetic Resonance Imaging Is an Independent Predictor of Adverse Cardiovascular Events.

Journal Article JACC Cardiovasc Imaging · August 2019 OBJECTIVES: The aim of this study was to evaluate the incremental prognostic value of global coronary flow reserve (CFR) in patients with known or suspected coronary artery disease who were undergoing stress cardiac magnetic resonance (CMR) imaging. BACKGR ... Full text Link to item Cite

MYOCARDIAL FIBROSIS AND PROGNOSIS IN HEART TRANSPLANT RECIPIENTS

Conference JOURNAL OF INVESTIGATIVE MEDICINE · June 1, 2019 Full text Link to item Cite

Myocardial Involvement in Patients With Histologically Diagnosed Cardiac Sarcoidosis: A Systematic Review and Meta-Analysis of Gross Pathological Images From Autopsy or Cardiac Transplantation Cases.

Journal Article J Am Heart Assoc · May 21, 2019 Background In patients with suspected cardiac sarcoidosis, late gadolinium enhancement on cardiovascular magnetic resonance imaging and/or 18F-fluorodeoxyglucose uptake on positron emission tomography are often used to reach a clinical diagnosis of cardiac ... Full text Link to item Cite

Prognostic Value of Vasodilator Stress Cardiac Magnetic Resonance Imaging: A Multicenter Study With 48 000 Patient-Years of Follow-up.

Journal Article JAMA Cardiol · March 1, 2019 IMPORTANCE: Stress cardiac magnetic resonance imaging (CMR) is not widely used in current clinical practice, and its ability to predict patient mortality is unknown. OBJECTIVE: To determine whether stress CMR is associated with patient mortality. DESIGN, S ... Full text Link to item Cite

STRESS CMR IN ABNORMAL LVEF: CLINICAL IMPACT AND COST EFFECTIVENESS

Conference Journal of the American College of Cardiology · March 2019 Full text Cite

Safety and prognostic value of regadenoson stress cardiovascular magnetic resonance imaging in heart transplant recipients.

Journal Article J Cardiovasc Magn Reson · January 24, 2019 BACKGROUND: There is a critical need for non-invasive methods to detect coronary allograft vasculopathy and to risk stratify heart transplant recipients. Vasodilator stress testing using cardiovascular magnetic resonance imaging (CMR) is a promising techni ... Full text Link to item Cite

Impact of Cardiovascular Magnetic Resonance Imaging on Identifying the Etiology of Cardiomyopathy in Patients Undergoing Cardiac Transplantation.

Journal Article Sci Rep · November 1, 2018 Errors in identifying the etiology of cardiomyopathy have been described in patients undergoing cardiac transplantation. There are increasing data that cardiovascular magnetic resonance imaging (CMR) provides unique diagnostic information in heart failure. ... Full text Link to item Cite

Feature-Tracking Global Longitudinal Strain Predicts Death in a Multicenter Population of Patients With Ischemic and Nonischemic Dilated Cardiomyopathy Incremental to Ejection Fraction and Late Gadolinium Enhancement.

Journal Article JACC Cardiovasc Imaging · October 2018 OBJECTIVES: The aim of this study was to evaluate the prognostic value of cardiac magnetic resonance (CMR) feature-tracking-derived global longitudinal strain (GLS) in a large multicenter population of patients with ischemic and nonischemic dilated cardiom ... Full text Link to item Cite

Secundum atrial septal defect.

Journal Article QJM · August 1, 2018 Full text Link to item Cite

Cardiomyopathy in Friedreich's Ataxia.

Journal Article Eur Heart J · February 14, 2018 Full text Link to item Cite

Left Ventricular Long-Axis Function Assessed with Cardiac Cine MR Imaging Is an Independent Predictor of All-Cause Mortality in Patients with Reduced Ejection Fraction: A Multicenter Study.

Journal Article Radiology · February 2018 Purpose To evaluate the prognostic value of a simple index of left ventricular (LV) long-axis function-lateral mitral annular plane systolic excursion (MAPSE)-in a large multicenter population of patients with reduced ejection fraction (EF) who were underg ... Full text Link to item Cite

Cost-Effectiveness Analysis for Cardiovascular Magnetic Resonance Imaging

Chapter · January 1, 2018 Despite a decline in deaths from coronary artery disease in many developed countries, growth in cardiac imaging has contributed to rising health care expenditures over the last few decades. Given these rising costs, there is increasing pressure from govern ... Full text Cite

Cardiovascular PET/MR: We need evidence, not hype.

Journal Article J Nucl Cardiol · June 2017 Recent introduction of hybrid positron emission tomography/magnetic resonance (PET/MR) scanners has created excitement regarding potential applications in cardiovascular medicine. This has led to a number of optimistic assessments of its potential value in ... Full text Link to item Cite

Accuracy of left ventricular ejection fraction by contemporary multiple gated acquisition scanning in patients with cancer: comparison with cardiovascular magnetic resonance.

Journal Article J Cardiovasc Magn Reson · March 24, 2017 BACKGROUND: Multiple gated acquisition scanning (MUGA) is a common imaging modality for baseline and serial assessment of left ventricular ejection fraction (LVEF) for cardiotoxicity risk assessment prior to, surveillance during, and surveillance after adm ... Full text Link to item Cite

Cardiac MRI and acute myocarditis.

Journal Article QJM · March 1, 2017 Full text Link to item Cite

Impact of Stress Cardiac Magnetic Resonance Imaging on Clinical Care.

Journal Article Am J Cardiol · September 15, 2016 Given the rising costs of imaging, there is increasing pressure to provide evidence for direct additive impact on clinical care. Appropriate use criteria (AUC) were developed to optimize test-patient selection and are increasingly used by payers to assess ... Full text Link to item Cite

Left ventricular long axis function assessed during cine-cardiovascular magnetic resonance is an independent predictor of adverse cardiac events.

Journal Article J Cardiovasc Magn Reson · June 7, 2016 BACKGROUND: Left ventricular pump function requires a complex interplay involving myocardial fibers orientated in the longitudinal, oblique and circumferential directions. Long axis dysfunction appears to be an early marker for a number of pathological sta ... Full text Link to item Cite

A 28-year-old man with chest and joint pains.

Journal Article Heart · May 15, 2016 CLINICAL INTRODUCTION: A 28-year-old man with extensive travel history to developing countries was hospitalised for intermittent sharp chest pains, worst when supine and with inspiration. Two weeks prior to presentation, he had suffered a flu-like illness ... Full text Link to item Cite

Role of Mitochondrial Oxidative Stress in Glucose Tolerance, Insulin Resistance, and Cardiac Diastolic Dysfunction.

Journal Article J Am Heart Assoc · May 5, 2016 BACKGROUND: Diabetes mellitus (DM) is associated with mitochondrial oxidative stress. We have shown that myocardial oxidative stress leads to diastolic dysfunction in a hypertensive mouse model. Therefore, we hypothesized that diabetes mellitus could cause ... Full text Link to item Cite

Resistant hypertension.

Journal Article Am J Med · October 2015 Full text Link to item Cite

Comparison of the prognostic value of regadenoson and adenosine myocardial perfusion imaging.

Journal Article J Nucl Cardiol · August 2015 BACKGROUND: Regadenoson is now widely used in single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI). However, the prognostic value of abnormal stress perfusion findings with regadenoson vs adenosine are unclear. The aim of t ... Full text Link to item Cite

Downstream clinical consequences of stress cardiovascular magnetic resonance based on appropriate use criteria.

Journal Article J Cardiovasc Magn Reson · May 15, 2015 BACKGROUND: Appropriate use criteria (AUC) have been developed by professional organizations as a response to the rising costs of imaging, with the goal of optimizing test-patient selection. Consequently, the AUC are now increasingly used by third-party-pa ... Full text Link to item Cite

A continuous murmur.

Journal Article Postgrad Med J · May 2015 Full text Link to item Cite

Mammoth ventricular hypertrophy.

Journal Article Circulation · February 3, 2015 Full text Link to item Cite

Paradoxical embolism in Ebstein's anomaly.

Journal Article Eur Heart J · February 1, 2015 Full text Link to item Cite

Ischaemia change with revascularisation versus medical therapy in reduced ejection fraction.

Journal Article Open Heart · 2015 OBJECTIVE: Nuclear imaging data demonstrate that revascularisation leads to favourable effects on ischaemia burden and improved outcomes compared with medical therapy (MT). In patients with heart failure (HF), the effects of MT versus revascularisation on ... Full text Open Access Link to item Cite

Routine cine-CMR for prosthesis-associated mitral regurgitation: a multicenter comparison to echocardiography.

Journal Article J Heart Valve Dis · September 2014 BACKGROUND AND AIM OF THE STUDY: Mitral regurgitation (MR) is an important complication after prosthetic mitral valve (PMV) implantation. Transthoracic echocardiography is widely used to screen for native MR, but can be limited with PMV. Cine-cardiac magne ... Link to item Cite

An unusual cause of dyspnoea in a young man.

Journal Article Eur Heart J · July 21, 2014 Full text Link to item Cite

Assessment of global myocardial perfusion reserve using cardiovascular magnetic resonance of coronary sinus flow at 3 Tesla.

Journal Article J Cardiovasc Magn Reson · March 27, 2014 BACKGROUND: Despite increasing clinical use, there is limited data regarding regadenoson in stress perfusion cardiovascular magnetic resonance (CMR). In particular, given its long half-life the optimal stress protocol remains unclear. Although Myocardial P ... Full text Link to item Cite

Palpitations in a 64-year-old man.

Journal Article Heart · January 2014 A 64-year-old man presented with several weeks of intermittent irregular palpitations. He had no prior history of cardiac disease, hypertension or syncope. A 12-lead ECG revealed sinus rhythm with premature atrial and ventricular contractions and high QRS ... Full text Link to item Cite

Palpitations in a 64-year-old man

Journal Article Heart · January 1, 2014 A 64-year-old man presented with several weeks of intermittent irregular palpitations. He had no prior history of cardiac disease, hypertension or syncope. A 12-lead ECG revealed sinus rhythm with premature atrial and ventricular contractions and high QRS ... Full text Cite

Applications and limitations of cardiac computed tomography in the evaluation of coronary artery disease.

Journal Article Coron Artery Dis · November 2013 Cardiac computed tomography angiography (CCTA) has rapidly emerged in recent years as a promising noninvasive imaging modality for the evaluation of coronary artery disease. This is predominantly because of its proven ability to exclude coronary stenosis i ... Full text Link to item Cite

Impact of cardiovascular magnetic resonance on management and clinical decision-making in heart failure patients.

Journal Article J Cardiovasc Magn Reson · October 1, 2013 BACKGROUND: Cardiovascular magnetic resonance (CMR) can provide important diagnostic and prognostic information in patients with heart failure. However, in the current health care environment, use of a new imaging modality like CMR requires evidence for di ... Full text Link to item Cite

MITOCHONDRIA-TARGETED ANTIOXIDANT AMELIORATES DIET-INDUCED DIABETES AND DIASTOLIC DYSFUNCTION

Conference Journal of the American College of Cardiology · March 2013 Full text Cite

Hydroxychloroquine: a treatable cause of cardiomyopathy.

Journal Article J Am Coll Cardiol · August 21, 2012 Full text Link to item Cite

Ischemia change in stable coronary artery disease is an independent predictor of death and myocardial infarction.

Journal Article JACC Cardiovasc Imaging · July 2012 OBJECTIVES: The aim of this study was to evaluate the independent prognostic significance of ischemia change in stable coronary artery disease (CAD). BACKGROUND: Recent randomized trials in stable CAD have suggested that revascularization does not improve ... Full text Link to item Cite

Detecting acute coronary syndromes by magnetic resonance imaging

Journal Article Heart and Metabolism · June 2, 2011 Only a small subset of the many patients presenting with chest pain are eventually diagnosed with acute coronary syndromes (ACS). Early identification of this high-risk group can be challenging, particularly since many will initially have non-diagnostic el ... Cite

Left atrial passive emptying function during dobutamine stress MR imaging is a predictor of cardiac events in patients with suspected myocardial ischemia.

Journal Article JACC Cardiovasc Imaging · April 2011 OBJECTIVES: The aim of this study was to determine the prognostic value of assessing left atrial function during dobutamine stress testing. BACKGROUND: Left ventricular diastolic dysfunction precedes systolic wall motion abnormalities in the ischemic casca ... Full text Link to item Cite

Measuring myocardial scar by CMR.

Journal Article JACC Cardiovasc Imaging · February 2011 Full text Link to item Cite

Cardiovascular magnetic resonance in patients with myocardial infarction: current and emerging applications.

Journal Article J Am Coll Cardiol · December 29, 2009 In patients with known or suspected myocardial infarction (MI), cardiovascular magnetic resonance (CMR) provides a comprehensive, multifaceted view of the heart. The data, including that from a recent multicenter clinical trial, indicate that delayed-enhan ... Full text Link to item Cite

Cardiovascular events during World Cup soccer.

Journal Article N Engl J Med · May 29, 2008 Link to item Cite

Relationship of antiphospholipid antibodies to cardiovascular manifestations of systemic lupus erythematosus.

Journal Article Arthritis Rheum · December 2006 OBJECTIVE: Although antiphospholipid antibodies (aPL) are associated with arterial and venous thrombosis in systemic lupus erythematosus (SLE), the extent to which they influence other cardiovascular manifestations is either controversial or uncertain. We ... Full text Link to item Cite

Images in clinical medicine. Pseudoclubbing.

Journal Article N Engl J Med · April 13, 2006 Full text Link to item Cite

Cullen's and Turner's signs.

Journal Article N Engl J Med · March 2, 2006 Full text Link to item Cite

Accelerated atherosclerosis in rheumatoid arthritis and systemic lupus erythematosus.

Journal Article Int J Clin Pract · July 2005 It is important for primary care physicians to recognise rheumatoid arthritis and systemic lupus erythematosus patients as high-risk groups for atherosclerosis, requiring aggressive risk-factor modification. Recent studies suggest that this increased risk ... Full text Link to item Cite

Idiopathic ventricular outflow tract tachycardia.

Journal Article Heart · February 2005 Although the pathogenesis of ventricular outflow tract tachycardia has not been fully elucidated, recent findings suggest that defects in cAMP signalling may be involved. ... Full text Link to item Cite

Biology of vascular calcification in renal disease.

Journal Article Nephron Exp Nephrol · 2005 The high rates of atherosclerotic vascular disease in patients with end-stage renal disease (ESRD) cannot be fully explained by the excess of traditional risk factors. Interest has therefore arisen in the possible role of vascular calcification, which is i ... Full text Link to item Cite

Adults with repaired tetralogy of fallot: Fixed but not cured

Journal Article Cardiovascular Reviews and Reports · July 1, 2003 Pulmonary regurgitation with progressive RV dysfunction is the most common hemodynamic problem encountered in patients with repaired Tetralogy of Fallot. Evaluation of pulmonary regurgitation and RV function requires a combination of Echocardiography and M ... Cite

Clinical cardiology rounds at New York-Cornell: Diastolic heart failure

Journal Article Cardiovascular Reviews and Reports · April 1, 2003 Cite

Pericarditis: Acute and recurrent

Journal Article Cardiovascular Reviews and Reports · February 1, 2003 Cite

Malposition of a pacemaker lead.

Journal Article N Engl J Med · June 20, 2002 Full text Link to item Cite

A polymorphism of the human matrix gamma-carboxyglutamic acid protein promoter alters binding of an activating protein-1 complex and is associated with altered transcription and serum levels.

Journal Article J Biol Chem · August 31, 2001 Matrix gamma-carboxyglutamic acid protein (MGP) is a mineral-binding extracellular matrix protein synthesized by vascular smooth muscle cells (VSMCs) and chondrocytes that is thought to be a key regulator of tissue calcification. In this study, we identifi ... Full text Link to item Cite

Inflammatory mechanisms.

Journal Article Br Med Bull · 2001 Traditional concepts of the pathogenesis of acute coronary syndromes have changed over the last few years. In particular it has been demonstrated that high-risk lesions are not necessarily angiographically severe. Rather, unstable high risk lesions are the ... Full text Link to item Cite

Transcriptional regulation of matrix gla protein.

Journal Article Z Kardiol · 2001 Matrix Gla Protein (MGP) is a small protein which is thought to be an inhibitor of tissue calcification and a regulator of cell differentiation. In this study we have examined the transcriptional regulation of MGP within rat vascular smooth muscle cells (V ... Full text Link to item Cite

The role of apoptosis in the initiation of vascular calcification.

Journal Article Z Kardiol · 2001 The initiation sites for calcification in cartilage and bone are cellular products called matrix vesicles. Similar structures have been found in calcified arteries and recent studies suggest that these may be derived from apoptotic cells. It is well establ ... Full text Link to item Cite

Aortic stiffness and calcification.

Journal Article Eur Heart J · January 2001 Full text Link to item Cite

Aortic-valve stenosis.

Journal Article Lancet · November 4, 2000 Full text Link to item Cite

Matrix gla protein is regulated by a mechanism functionally related to the calcium-sensing receptor.

Journal Article Biochem Biophys Res Commun · November 2, 2000 Matrix Gla protein (MGP) is a mineral binding extra-cellular matrix protein which is thought to be a key inhibitor of tissue and vascular calcification. It is known to be upregulated in areas of extracellular calcification possibly to limit further harmful ... Full text Link to item Cite

The role of Gla proteins in vascular calcification.

Journal Article Crit Rev Eukaryot Gene Expr · 1998 Arterial calcification occurs with increasing age and in association with a diverse range of diseases, including atherosclerosis, diabetes, and uremia. It occurs at two sites in the vessel wall--in the media where it is known as Monckeberg's sclerosis and ... Full text Link to item Cite