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Alaattin Erkanli

Associate Professor of Biostatistics & Bioinformatics
Biostatistics & Bioinformatics, Division of Biostatistics
Hock Plaza Box 2721, Durham, NC 27710
Duke University Medical Center 2424, Erwin Road Suite 110 Hock Plaza Box 2721, Durham, NC 27710

Selected Publications


Evaluation of Tacrolimus Concentrations and Clinical Outcomes Between Extended and Immediate Release Formulations in Kidney Transplant.

Journal Article J Pharm Pract · April 29, 2024 Objectives: Tacrolimus remains the mainstay of immunosuppression in kidney transplantation. Understanding the relationship between therapeutic tacrolimus levels and outcomes of acute rejection, patient/graft survival, and tolerability are important. The re ... Full text Link to item Cite

Utility of Methicillin-Resistant Staphylococcus aureus Nasal PCR Testing in Pediatric Patients With Suspected Respiratory Infections.

Journal Article J Pediatric Infect Dis Soc · April 24, 2024 Observational studies in adults suggest nasal methicillin-resistant Staphylococcus aureus (MRSA) swabs have a high negative predictive value (NPV) for ruling out MRSA pneumonia, however, pediatric data are limited. This retrospective study of 505 pediatric ... Full text Link to item Cite

Telemedicine services in higher education: a review of college and university websites.

Journal Article J Am Coll Health · 2024 OBJECTIVES: To identify rates of telemedicine provision during the COVID-19 pandemic and predictive institutional factors among 4-year and graduate colleges and universities. PARTICIPANTS: The study (n = 364) included the websites (.edu) of accredited publ ... Full text Link to item Cite

Cryocompression to Reduce Peripheral Neuropathy in Gynecologic Cancer: A Randomized Controlled Trial.

Journal Article Obstet Gynecol · December 1, 2023 OBJECTIVE: To investigate the efficacy of cryocompression therapy to prevent chemotherapy-induced peripheral neuropathy. METHODS: This single-institution, randomized, self-controlled trial of cryocompression enrolled gynecologic cancer patients planned for ... Full text Link to item Cite

Reported changes in romantic and sexual behavior among college and graduate students during COVID-19.

Journal Article J Am Coll Health · November 28, 2023 Objective: To understand changes in romantic and sexual behavior among college and graduate students in North Carolina during COVID-19. Participants: Participants were between 18-30 years old and enrolled in a two- or four-year college or graduate program ... Full text Link to item Cite

Clinical and radiation risk across one million patients in Computed Tomography: influence of age, size, and race

Conference · November 26, 2023 Purpose. We recently developed a mathematical model to balance radiation risk and clinical risk, namely the risk of misdiagnosis due to insufficient image quality. In this work, we applied this model to a population of one million CT imaging cases to evalu ... Open Access Cite

Geographic variation in the rate and route of hysterectomy for benign disease in the USA: A retrospective cross-sectional study.

Journal Article BJOG · November 2023 OBJECTIVES: To describe population rate of hysterectomy for benign disease in the USA, including geographic variation across states and Hospital Service Areas (HSAs; areas defined by common patient flows to healthcare facilities). DESIGN: Cross-sectional s ... Full text Link to item Cite

Patient and Surgery Characteristics of Inpatient Hysterectomies Among Transgender Individuals.

Journal Article LGBT Health · October 2023 Purpose: The purpose of this study is to estimate population-based rates of inpatient hysterectomy and accompanying bilateral salpingo-oophorectomy by indication and evaluate surgical patient characteristics by indication, year, patient age, and hospital l ... Full text Link to item Cite

Preemptive immune globulin therapy in sensitized lung transplant recipients.

Journal Article Transpl Immunol · October 2023 BACKGROUND: Sensitized lung transplant recipients are at increased risk of developing donor-specific antibodies, which have been associated with acute and chronic rejection. Perioperative intravenous immune globulin has been used in sensitized individuals ... Full text Link to item Cite

Gender and Language in Letters of Recommendation for Obstetrics and Gynecology Fellowship Applications.

Journal Article J Surg Educ · October 2023 OBJECTIVE: To delineate the use of gender-biased language in letters of recommendation for Obstetrics and Gynecology fellowships and its impact on applicants. DESIGN: Fellowship letters of recommendation from 4 Obstetrics and Gynecology specialties at a si ... Full text Link to item Cite

Propofol-Associated Hypertriglyceridemia in Adults With Acute Respiratory Distress Syndrome on Extracorporeal Membrane Oxygenation.

Journal Article ASAIO J · September 1, 2023 The incidence and risk factors for propofol-associated hypertriglyceridemia (HTG) in patients receiving extracorporeal membrane oxygenation (ECMO) have not been evaluated. The purpose of this study was to determine the incidence and risk factors for propof ... Full text Link to item Cite

Comparison of Open-Access, Trough-Only Online Calculators Versus Trapezoidal Method for Calculation of Vancomycin Area Under the Curve (AUC).

Journal Article Ann Pharmacother · August 2023 BACKGROUND: Vancomycin area-under-the-curve (AUC) monitoring is associated with reduced nephrotoxicity but may increase cost and workload for personnel compared to trough monitoring. OBJECTIVE: The purpose of this study was to compare the accuracy of vanco ... Full text Link to item Cite

Exploratory analysis of mesenteric-portal axis CT radiomic features for survival prediction of patients with pancreatic ductal adenocarcinoma.

Journal Article Eur Radiol · August 2023 OBJECTIVE: To develop and evaluate task-based radiomic features extracted from the mesenteric-portal axis for prediction of survival and response to neoadjuvant therapy in patients with pancreatic ductal adenocarcinoma (PDAC). METHODS: Consecutive patients ... Full text Link to item Cite

Validation of a sonographic checklist for the detection of histologic placenta accreta spectrum.

Journal Article Am J Obstet Gynecol MFM · August 2023 BACKGROUND: To standardize research terminology and to reduce unanticipated placenta accreta spectrum, the European Working Group for Abnormally Invasive Placenta developed a consensus checklist for reporting suspected placenta accreta spectrum observed du ... Full text Link to item Cite

Standard Restrictions vs Expedited Activity After Pelvic Organ Prolapse Surgery: A Randomized Clinical Trial.

Journal Article JAMA Surg · August 1, 2023 IMPORTANCE: Restrictions on postoperative activity following pelvic organ prolapse (POP) surgery are not evidence based. Nonetheless, many pelvic surgeons place lifting and activity restrictions on patients following surgery. OBJECTIVE: To evaluate whether ... Full text Link to item Cite

Prospective Observational Study of N-terminal Pro-Brain Natriuretic Peptide Levels in Obese and Nonobese Women during Pregnancy.

Journal Article Am J Perinatol · April 2023 OBJECTIVE: N-terminal pro-brain natriuretic peptide (NT-proBNP), a marker of ventricular dysfunction, varies by body mass index (BMI) outside of pregnancy. This study aimed to determine whether obesity affects NT-proBNP levels in pregnancy. STUDY DESIGN: T ... Full text Link to item Cite

Contraceptive Access and Use Among Undergraduate and Graduate Students During COVID-19: Online Survey Study.

Journal Article JMIR Form Res · March 14, 2023 BACKGROUND: The COVID-19 pandemic led to widespread college campus closures in the months of March to June 2020, endangering students' access to on-campus health resources, including reproductive health services. OBJECTIVE: To assess contraceptive access a ... Full text Link to item Cite

Evaluation of Tacrolimus Concentrations and Clinical Outcomes Between Extended and Immediate Release Formulations in Kidney Transplant.

Journal Article J Pharm Pract · April 29, 2024 Objectives: Tacrolimus remains the mainstay of immunosuppression in kidney transplantation. Understanding the relationship between therapeutic tacrolimus levels and outcomes of acute rejection, patient/graft survival, and tolerability are important. The re ... Full text Link to item Cite

Utility of Methicillin-Resistant Staphylococcus aureus Nasal PCR Testing in Pediatric Patients With Suspected Respiratory Infections.

Journal Article J Pediatric Infect Dis Soc · April 24, 2024 Observational studies in adults suggest nasal methicillin-resistant Staphylococcus aureus (MRSA) swabs have a high negative predictive value (NPV) for ruling out MRSA pneumonia, however, pediatric data are limited. This retrospective study of 505 pediatric ... Full text Link to item Cite

Telemedicine services in higher education: a review of college and university websites.

Journal Article J Am Coll Health · 2024 OBJECTIVES: To identify rates of telemedicine provision during the COVID-19 pandemic and predictive institutional factors among 4-year and graduate colleges and universities. PARTICIPANTS: The study (n = 364) included the websites (.edu) of accredited publ ... Full text Link to item Cite

Cryocompression to Reduce Peripheral Neuropathy in Gynecologic Cancer: A Randomized Controlled Trial.

Journal Article Obstet Gynecol · December 1, 2023 OBJECTIVE: To investigate the efficacy of cryocompression therapy to prevent chemotherapy-induced peripheral neuropathy. METHODS: This single-institution, randomized, self-controlled trial of cryocompression enrolled gynecologic cancer patients planned for ... Full text Link to item Cite

Reported changes in romantic and sexual behavior among college and graduate students during COVID-19.

Journal Article J Am Coll Health · November 28, 2023 Objective: To understand changes in romantic and sexual behavior among college and graduate students in North Carolina during COVID-19. Participants: Participants were between 18-30 years old and enrolled in a two- or four-year college or graduate program ... Full text Link to item Cite

Clinical and radiation risk across one million patients in Computed Tomography: influence of age, size, and race

Conference · November 26, 2023 Purpose. We recently developed a mathematical model to balance radiation risk and clinical risk, namely the risk of misdiagnosis due to insufficient image quality. In this work, we applied this model to a population of one million CT imaging cases to evalu ... Open Access Cite

Geographic variation in the rate and route of hysterectomy for benign disease in the USA: A retrospective cross-sectional study.

Journal Article BJOG · November 2023 OBJECTIVES: To describe population rate of hysterectomy for benign disease in the USA, including geographic variation across states and Hospital Service Areas (HSAs; areas defined by common patient flows to healthcare facilities). DESIGN: Cross-sectional s ... Full text Link to item Cite

Patient and Surgery Characteristics of Inpatient Hysterectomies Among Transgender Individuals.

Journal Article LGBT Health · October 2023 Purpose: The purpose of this study is to estimate population-based rates of inpatient hysterectomy and accompanying bilateral salpingo-oophorectomy by indication and evaluate surgical patient characteristics by indication, year, patient age, and hospital l ... Full text Link to item Cite

Preemptive immune globulin therapy in sensitized lung transplant recipients.

Journal Article Transpl Immunol · October 2023 BACKGROUND: Sensitized lung transplant recipients are at increased risk of developing donor-specific antibodies, which have been associated with acute and chronic rejection. Perioperative intravenous immune globulin has been used in sensitized individuals ... Full text Link to item Cite

Gender and Language in Letters of Recommendation for Obstetrics and Gynecology Fellowship Applications.

Journal Article J Surg Educ · October 2023 OBJECTIVE: To delineate the use of gender-biased language in letters of recommendation for Obstetrics and Gynecology fellowships and its impact on applicants. DESIGN: Fellowship letters of recommendation from 4 Obstetrics and Gynecology specialties at a si ... Full text Link to item Cite

Propofol-Associated Hypertriglyceridemia in Adults With Acute Respiratory Distress Syndrome on Extracorporeal Membrane Oxygenation.

Journal Article ASAIO J · September 1, 2023 The incidence and risk factors for propofol-associated hypertriglyceridemia (HTG) in patients receiving extracorporeal membrane oxygenation (ECMO) have not been evaluated. The purpose of this study was to determine the incidence and risk factors for propof ... Full text Link to item Cite

Comparison of Open-Access, Trough-Only Online Calculators Versus Trapezoidal Method for Calculation of Vancomycin Area Under the Curve (AUC).

Journal Article Ann Pharmacother · August 2023 BACKGROUND: Vancomycin area-under-the-curve (AUC) monitoring is associated with reduced nephrotoxicity but may increase cost and workload for personnel compared to trough monitoring. OBJECTIVE: The purpose of this study was to compare the accuracy of vanco ... Full text Link to item Cite

Exploratory analysis of mesenteric-portal axis CT radiomic features for survival prediction of patients with pancreatic ductal adenocarcinoma.

Journal Article Eur Radiol · August 2023 OBJECTIVE: To develop and evaluate task-based radiomic features extracted from the mesenteric-portal axis for prediction of survival and response to neoadjuvant therapy in patients with pancreatic ductal adenocarcinoma (PDAC). METHODS: Consecutive patients ... Full text Link to item Cite

Validation of a sonographic checklist for the detection of histologic placenta accreta spectrum.

Journal Article Am J Obstet Gynecol MFM · August 2023 BACKGROUND: To standardize research terminology and to reduce unanticipated placenta accreta spectrum, the European Working Group for Abnormally Invasive Placenta developed a consensus checklist for reporting suspected placenta accreta spectrum observed du ... Full text Link to item Cite

Standard Restrictions vs Expedited Activity After Pelvic Organ Prolapse Surgery: A Randomized Clinical Trial.

Journal Article JAMA Surg · August 1, 2023 IMPORTANCE: Restrictions on postoperative activity following pelvic organ prolapse (POP) surgery are not evidence based. Nonetheless, many pelvic surgeons place lifting and activity restrictions on patients following surgery. OBJECTIVE: To evaluate whether ... Full text Link to item Cite

Prospective Observational Study of N-terminal Pro-Brain Natriuretic Peptide Levels in Obese and Nonobese Women during Pregnancy.

Journal Article Am J Perinatol · April 2023 OBJECTIVE: N-terminal pro-brain natriuretic peptide (NT-proBNP), a marker of ventricular dysfunction, varies by body mass index (BMI) outside of pregnancy. This study aimed to determine whether obesity affects NT-proBNP levels in pregnancy. STUDY DESIGN: T ... Full text Link to item Cite

Contraceptive Access and Use Among Undergraduate and Graduate Students During COVID-19: Online Survey Study.

Journal Article JMIR Form Res · March 14, 2023 BACKGROUND: The COVID-19 pandemic led to widespread college campus closures in the months of March to June 2020, endangering students' access to on-campus health resources, including reproductive health services. OBJECTIVE: To assess contraceptive access a ... Full text Link to item Cite

Direct-to-consumer fertility testing: utilization and perceived utility among fertility patients and reproductive endocrinologists.

Journal Article Reprod Biomed Online · March 2023 RESEARCH QUESTION: What is the utilization of direct-to-consumer fertility tests (DTCFT) among fertility patients? How does the perceived utility of DTCFT differ between patients and reproductive endocrinologists (REI)? DESIGN: Infertility patients visitin ... Full text Link to item Cite

Abstract P4-01-10: Evaluating the safety of tucatinib in combination with trastuzumab and capecitabine for human epidermal growth factor 2 (HER2)-positive metastatic breast cancer in a real-world setting

Conference Cancer Research · March 1, 2023 AbstractBackground: Tucatinib, a highly selective tyrosine kinase inhibitor (TKI) for human epidermal growth factor 2 (HER2) receptor, received FDA approval in combination with trastuzumab and capecitabine f ... Full text Cite

Utility of a risk assessment model in predicting 30 day unplanned hospital readmission in adult patients receiving outpatient parenteral antimicrobial therapy.

Journal Article JAC Antimicrob Resist · February 2023 OBJECTIVES: Outpatient parenteral antimicrobial therapy (OPAT) is associated with high hospital readmission rates. A 30 day unplanned readmission risk prediction model for OPAT patients has been developed in the UK. Given significant differences in patient ... Full text Link to item Cite

Markers of ovarian reserve as predictors of future fertility.

Journal Article Fertil Steril · January 2023 OBJECTIVE: To determine the association between ovarian reserve biomarkers and future fertility among late reproductive-age women. DESIGN: Cohort study of participants enrolled in Time to Conceive (TTC), a time-to-pregnancy cohort study of the ovarian rese ... Full text Link to item Cite

Evaluation of phenobarbital dosing strategies for hospitalized patients with alcohol withdrawal syndrome.

Journal Article Gen Hosp Psychiatry · 2023 OBJECTIVE: Alcohol remains the fourth‑leading preventable cause of death in the U.S. The objective of this study was to compare the incidence of phenobarbital (PHB)-resistant withdrawal and determine risk factors for PHB-resistant alcohol withdrawal syndro ... Full text Link to item Cite

Clinical and imaging predictors of the natural course of bland portal vein thrombus in cirrhotic patients.

Journal Article Abdom Radiol (NY) · November 2022 BACKGROUND: Portal vein thrombus (PVT) in cirrhotic patients is associated with worsening portal hypertension, leads to increased complexity of necessary interventions such as transjugular liver portosystemic shunt or liver transplantation, and is associat ... Full text Link to item Cite

Improving well-being for individuals with persistent pain after surgery for breast cancer, lobular carcinoma in situ, or ductal carcinoma in situ: A randomized clinical trial.

Journal Article Contemp Clin Trials · November 2022 >276,000 Americans will be diagnosed with invasive breast cancer, lobular carcinoma in situ, or ductal carcinoma in situ this year and most will undergo breast surgery as part of their care. Although prognosis is excellent, many patients experience persist ... Full text Link to item Cite

Evaluating a couple communication skills training (CCST) intervention for advanced cancer: study protocol for a randomized controlled trial.

Journal Article Trials · August 26, 2022 BACKGROUND: For patients and their intimate partners, advanced cancer poses significant challenges that can negatively impact both individuals and their relationship. Prior studies have found evidence that couple-based communication skills interventions ca ... Full text Link to item Cite

Noninvasive diagnosis of pulmonary hypertension with hyperpolarised 129Xe magnetic resonance imaging and spectroscopy.

Conference ERJ Open Res · April 2022 BACKGROUND: The diagnosis of pulmonary hypertension (PH) remains challenging. Pre- and post-capillary PH have different signatures on noninvasive 129Xe gas-exchange magnetic resonance imaging (MRI) and dynamic MR spectroscopy (MRS). We tested the accuracy ... Full text Link to item Cite

Clinical factors associated with cytomegalovirus shedding among seropositive pregnant women.

Journal Article Am J Obstet Gynecol MFM · March 2022 BACKGROUND: Both neighborhood disadvantage and close contact with children have been associated with seroprevalence of cytomegalovirus in pregnancy. However, it is unknown which individual factors influence whether seropositive women are likely to have ong ... Full text Link to item Cite

Untapped Potential for Emergency Department Observation Unit Use: A National Hospital Ambulatory Medical Care Survey (NHAMCS) Study.

Journal Article West J Emerg Med · January 18, 2022 INTRODUCTION: Millions of people present to the emergency department (ED) with chest pain annually. Accurate and timely risk stratification is important to identify potentially life-threatening conditions such as acute coronary syndrome (ACS). An ED-based ... Full text Open Access Link to item Cite

The Implementation of Farm-to-University Program in Historically Black Colleges and Universities: Assessment of Feasibility and Barriers

Journal Article American Journal of Health Education · January 1, 2022 Background: Farm-to-University (Farm2U) programs make healthy eating accessible, easier, and the default option. Yet, few published studies have focused on Farm2U implementations in Historically Black Colleges and Universities (HBCUs) in conjunction with m ... Full text Cite

MARKERS OF OVARIAN RESERVE AS PREDICTORS OF FUTURE FERTILITY

Conference FERTILITY AND STERILITY · 2022 Cite

A mathematical framework to quantitatively balance clinical and radiation risk in Computed Tomography

Conference · December 1, 2021 Purpose: Risk in medical imaging is a combination of radiation risk and clinical risk, which is largely driven by the effective diagnosis. While radiation risk has traditionally been the main focus of Computed Tomography (CT) optimization, such a goal cann ... Open Access Cite

Histopathology after lidocaine/prilocaine cream administration for vulvar biopsy.

Journal Article J Cutan Pathol · October 2021 BACKGROUND: Case series have described disruptive histopathologic changes following lidocaine/prilocaine cream anesthetic for biopsies. METHODS: A study of histopathologic changes was performed following a randomized trial comparing topical lidocaine/prilo ... Full text Link to item Cite

United States Emergency Department Use of Medications with Pharmacogenetic Recommendations.

Journal Article West J Emerg Med · September 23, 2021 INTRODUCTION: Emergency departments (ED) use many medications with a range of therapeutic efficacy and potential significant side effects, and many medications have dosage adjustment recommendations based on the patient's specific genotype. How frequently ... Full text Open Access Link to item Cite

Variability in image quality and radiation dose within and across 97 medical facilities.

Journal Article J Med Imaging (Bellingham) · September 2021 Purpose: To characterize variability in image quality and radiation dose across a large cohort of computed tomography (CT) examinations and identify the scan factors with the highest influence on the observed variabilities. Approach: This retrospective ins ... Full text Link to item Cite

Placental uterine artery embolization followed by delayed hysterectomy for placenta percreta: A case series.

Journal Article Gynecol Oncol Rep · August 2021 We describe outcomes of patients with suspected placenta percreta treated with placental uterine artery embolization (P-UAE) followed by delayed hysterectomy. This is a prospective case series of subjects from 2005 to 2018 with suspected placenta percreta ... Full text Link to item Cite

Diagnosis of LI-RADS M lesions on gadoxetate-enhanced MRI: identifying cholangiocarcinoma-containing tumor with serum markers and imaging features.

Journal Article Eur Radiol · June 2021 OBJECTIVES: The LI-RADS M (LR-M) category describes hepatic lesions probably or definitely malignant, but not specific for hepatocellular carcinoma in at-risk patients. Differentiation among LR-M entities, particularly detecting cholangiocarcinoma-containi ... Full text Link to item Cite

How frequently does hepatocellular carcinoma develop in at-risk patients with a negative liver MRI examination with intravenous Gadobenate dimeglumine?

Journal Article Abdom Radiol (NY) · March 2021 OBJECTIVE: To determine the rate of development of clinically significant liver nodules (LR-4, LR-5, LR-M) after a negative MRI in an HCC screening population. METHODS: This retrospective study included patients at risk of developing HCC requiring imaging ... Full text Link to item Cite

Urine cytomegalovirus shedding among seropositive pregnant women

Conference AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY · 2021 Cite

A Method for Grouping Emergency Department Visits by Severity and Complexity.

Journal Article West J Emerg Med · August 21, 2020 INTRODUCTION: Triage functions to quickly prioritize care and sort patients by anticipated resource needs. Despite widespread use of the Emergency Severity Index (ESI), there is still no universal standard for emergency department (ED) triage. Thus, it can ... Full text Open Access Link to item Cite

Using the American College of Radiology Thyroid Imaging Reporting and Data System at the Point of Care: Sonographer Performance and Interobserver Variability.

Journal Article Ultrasound Med Biol · August 2020 The purpose of this study was to assess inter-observer variability and performance when sonographers assign features to thyroid nodules on ultrasound using the American College of Radiology (ACR) Thyroid Imaging Reporting and Data System (TI-RADS). Fifteen ... Full text Link to item Cite

Improving health engagement and lifestyle management for breast cancer survivors with diabetes.

Journal Article Contemp Clin Trials · May 2020 Breast cancer survivors with type 2 diabetes are at high risk for cancer recurrence, serious health complications, more severe symptoms, psychological distress, and premature death relative to breast cancer survivors without diabetes. Maintaining glycemic ... Full text Open Access Link to item Cite

Social Rejection and Suicidal Ideation and Attempts among Adolescents Following Hospitalization: a Prospective Study.

Journal Article J Abnorm Child Psychol · January 2020 Despite research indicating that stressful life events are associated with subsequent suicidal ideation (SI) and behavior, there is a lack of clarity regarding whether specific types of life events are differentially related to SI and attempts. The current ... Full text Link to item Cite

A Simulation Paradigm for Evaluation of Subtle Liver Lesions at Pediatric CT: Performance and Confidence.

Journal Article Radiol Imaging Cancer · September 2019 PURPOSE: To create and validate a systematic observer performance platform for evaluation of simulated liver lesions at pediatric CT and to test this paradigm to measure the effect of radiation dose reduction on detection performance and reader confidence. ... Full text Link to item Cite

Testing a behavioral intervention to improve adherence to adjuvant endocrine therapy (AET).

Journal Article Contemp Clin Trials · January 2019 Adjuvant endocrine therapy (AET) is used to prevent recurrence and reduce mortality for women with hormone receptor positive breast cancer. Poor adherence to AET is a significant problem and contributes to increased medical costs and mortality. A variety o ... Full text Open Access Link to item Cite

Portable Pocket colposcopy performs comparably to standard-of-care clinical colposcopy using acetic acid and Lugol's iodine as contrast mediators: an investigational study in Peru.

Journal Article BJOG · September 2018 OBJECTIVE: Our goal was to develop a tele-colposcopy platform for primary-care clinics to improve screening sensitivity and access. Specifically, we developed a low-cost, portable Pocket colposcope and evaluated its performance in a tertiary healthcare cen ... Full text Open Access Link to item Cite

Assessing effects of pressure on tumor and normal tissue physiology using an automated self-calibrated, pressure-sensing probe for diffuse reflectance spectroscopy.

Journal Article J Biomed Opt · May 2018 Diffuse reflectance spectroscopy (DRS) represents a quantitative, noninvasive, nondestructive means of assessing vascular oxygenation, vascularity, and structural properties. However, it is known that such measurements can be influenced by the effects of p ... Full text Link to item Cite

Metaboloptics: Visualization of the tumor functional landscape via metabolic and vascular imaging.

Journal Article Sci Rep · March 8, 2018 Many cancers adeptly modulate metabolism to thrive in fluctuating oxygen conditions; however, current tools fail to image metabolic and vascular endpoints at spatial resolutions needed to visualize these adaptations in vivo. We demonstrate a high-resolutio ... Full text Link to item Cite

Effects of religious versus conventional cognitive-behavioral therapy (CBT) on suicidal thoughts in major depression and chronic medical illness

Journal Article Psychology of Religion and Spirituality · February 1, 2018 We compared the effectiveness of religiously integrated cognitive-behavioral therapy (RCBT) versus conventional CBT (CCBT) on decreasing suicidal thoughts in persons with major depressive disorder (MDD) and chronic medical illness (CMI). Persons ages 18-85 ... Full text Cite

Clinical evaluation of a portable pocket colposcope for cervical cancer screening in the United States, Perú, and Tanzania

Conference 2017 IEEE Healthcare Innovations and Point of Care Technologies, HI-POCT 2017 · December 19, 2017 Cervical cancer is the second leading cause of cancer related deaths for women worldwide, despite being both preventable and treatable if detected early enough. The burden of disease persists in part due to a lack of access to early diagnostics and the fac ... Full text Cite

Distinct Angiogenic Changes during Carcinogenesis Defined by Novel Label-Free Dark-Field Imaging in a Hamster Cheek Pouch Model.

Journal Article Cancer Res · December 15, 2017 There remain gaps in knowledge concerning how vascular morphology evolves during carcinogenesis. In this study, we imaged neovascularization by label-free dark-field microscopy of a 7,12-Dimethylbenz[a]anthracene (DMBA)-induced hamster cheek pouch model of ... Full text Link to item Cite

Prospective Study of Major Loss Life Events and Risk for Suicidal Thoughts and Behaviors Among Adolescents and Young Adults.

Journal Article Suicide Life Threat Behav · August 2017 This prospective, naturalistic study examined the association between major loss life experiences, other psychiatric risk factors (depression, hopelessness, and anxiety), and suicidal thoughts and behaviors (STBs) among adolescents followed through young a ... Full text Link to item Cite

Effects of a 12-Month Educational Intervention on Clinicians' Attitudes/Practices Regarding the Screening Spiritual History.

Journal Article South Med J · June 2017 OBJECTIVES: Patients' spiritual values, beliefs, and preferences are identified in outpatient medical settings by the taking of a screening spiritual history (SSH). We report the impact of an educational/training program on the attitudes/practices of physi ... Full text Link to item Cite

Testing a behavioral intervention to improve adherence to adjuvant endocrine therapy (AET).

Conference Journal of Clinical Oncology · May 20, 2017 TPS10128 Background: Adjuvant endocrine therapy (AET) is a crucial component of treatment used to prevent recurrence and reduce mortality for women with hormone receptor positive breast cancer. Poor adherence to AET is a signific ... Full text Cite

International Image Concordance Study to Compare a Point-of-Care Tampon Colposcope With a Standard-of-Care Colposcope.

Journal Article J Low Genit Tract Dis · April 2017 OBJECTIVE: Barriers to cervical cancer screening in low-resource settings include lack of accessible, high-quality services, high cost, and the need for multiple visits. To address these challenges, we developed a low-cost, intravaginal, optical cervical i ... Full text Open Access Link to item Cite

Effects on Daily Spiritual Experiences of Religious Versus Conventional Cognitive Behavioral Therapy for Depression.

Journal Article J Relig Health · October 2016 We compared religiously integrated cognitive behavioral therapy (RCBT) versus conventional CBT (CCBT) on increasing daily spiritual experiences (DSE) in major depressive disorder and chronic medical illness. A total of 132 participants aged 18-85 were rand ... Full text Link to item Cite

Oxygen and Perfusion Kinetics in Response to Fractionated Radiation Therapy in FaDu Head and Neck Cancer Xenografts Are Related to Treatment Outcome.

Journal Article Int J Radiat Oncol Biol Phys · October 1, 2016 PURPOSE: To test whether oxygenation kinetics correlate with the likelihood for local tumor control after fractionated radiation therapy. METHODS AND MATERIALS: We used diffuse reflectance spectroscopy to noninvasively measure tumor vascular oxygenation an ... Full text Link to item Cite

Rapid staining and imaging of subnuclear features to differentiate between malignant and benign breast tissues at a point-of-care setting.

Journal Article J Cancer Res Clin Oncol · July 2016 PURPOSE: Histopathology is the clinical standard for tissue diagnosis; however, it requires tissue processing, laboratory personnel and infrastructure, and a highly trained pathologist to diagnose the tissue. Optical microscopy can provide real-time diagno ... Full text Link to item Cite

Antidepressant Regulatory Warnings, Prescription Patterns, Suicidality and Other Aggressive Behaviors in Major Depressive Disorder and Anxiety Disorders.

Journal Article Psychiatr Q · June 2016 In 2004 the Food and Drug Administration issued a warning on the risk of suicidality in children and adolescents receiving antidepressants. This was followed by reports of changes in antidepressant prescription patterns, suicidality and other aggressive be ... Full text Link to item Cite

Developmental Trajectories of Suicidal Thoughts and Behaviors From Adolescence Through Adulthood.

Journal Article J Am Acad Child Adolesc Psychiatry · May 2016 OBJECTIVE: Little is known about the patterns among individuals in the long-term course of suicidal thoughts and behaviors (STBs). The objective of this study was to identify developmental trajectories of STBs from adolescence through young adulthood, as w ... Full text Link to item Cite

A quantitative microscopic approach to predict local recurrence based on in vivo intraoperative imaging of sarcoma tumor margins.

Journal Article Int J Cancer · November 15, 2015 The goal of resection of soft tissue sarcomas located in the extremity is to preserve limb function while completely excising the tumor with a margin of normal tissue. With surgery alone, one-third of patients with soft tissue sarcoma of the extremity will ... Full text Link to item Cite

Genome-Wide Meta-Analysis of Longitudinal Alcohol Consumption Across Youth and Early Adulthood.

Journal Article Twin Res Hum Genet · August 2015 The public health burden of alcohol is unevenly distributed across the life course, with levels of use, abuse, and dependence increasing across adolescence and peaking in early adulthood. Here, we leverage this temporal patterning to search for common gene ... Full text Link to item Cite

Suicide attempts in a longitudinal sample of adolescents followed through adulthood: Evidence of escalation.

Journal Article J Consult Clin Psychol · April 2015 OBJECTIVES: This study was designed to examine escalation in repeat suicide attempts from adolescence through adulthood, as predicted by sensitization models (and reflected in increasing intent and lethality with repeat attempts, decreasing amount of time ... Full text Link to item Cite

Depressogenic vulnerability and gender-specific patterns of neuro-immune dysregulation: What the ratio of cortisol to C-reactive protein can tell us about loss of normal regulatory control.

Journal Article Brain Behav Immun · February 2015 We examined whether the ratio of cortisol (CORT) to high-sensitivity C-reactive protein (hsCRP), an index that captures the integrity of homeostatic regulation between the hypothalamic-pituitary-adrenal (HPA) axis and inflammatory processes, is associated ... Full text Link to item Cite

Estimating the causal effect of conduct disorder on the time from first substance use to substance use disorders using g-estimation.

Journal Article Subst Abus · 2014 BACKGROUND: The effect of conduct disorder (CD) as a major risk factor of substance use disorder (SUD), controlling for other psychiatric problems, has been well established in the literature. However, other psychiatric problems are associated as confounde ... Full text Link to item Cite

Sex-differentiated changes in C-reactive protein from ages 9 to 21: the contributions of BMI and physical/sexual maturation.

Journal Article Psychoneuroendocrinology · October 2013 BACKGROUND: Sex differences in levels of C-reactive protein (CRP) are well established in adulthood, but little is known about when and why they emerge. Here, we tested longitudinal models of CRP levels from ages 9 to 21, when marked physical and behaviora ... Full text Link to item Cite

Depression inhibits the anti-inflammatory effects of leisure time physical activity and light to moderate alcohol consumption.

Journal Article Brain Behav Immun · August 2013 Light to moderate alcohol consumption and leisure time physical activity (LTPA) are independently associated with lower levels of high sensitivity C-reactive protein (CRP), a predictor of cardiometabolic risk. In contrast, depression, ranging from low mood ... Full text Link to item Cite

Genes, environments, and developmental research: methods for a multi-site study of early substance abuse.

Journal Article Twin Res Hum Genet · April 2013 The importance of including developmental and environmental measures in genetic studies of human pathology is widely acknowledged, but few empirical studies have been published. Barriers include the need for longitudinal studies that cover relevant develop ... Full text Link to item Cite

Rapid determination of oxygen saturation and vascularity for cancer detection.

Journal Article PLoS One · 2013 A rapid heuristic ratiometric analysis for estimating tissue hemoglobin concentration and oxygen saturation from measured tissue diffuse reflectance spectra is presented. The analysis was validated in tissue-mimicking phantoms and applied to clinical measu ... Full text Link to item Cite

Indirect comorbidity in childhood and adolescence.

Journal Article Front Psychiatry · 2013 OBJECTIVE: Comorbidity between psychiatric disorders is common, but pairwise associations between two disorders may be explained by the presence of other diagnoses that are associated with both disorders or "indirect" comorbidity. MATERIALS AND METHODS: Co ... Full text Link to item Cite

Psychiatric diagnostic interviews for children and adolescents: a comparative study.

Journal Article J Am Acad Child Adolesc Psychiatry · May 2012 OBJECTIVE: To compare examples of three styles of psychiatric interviews for youth: the Diagnostic Interview Schedule for Children (DISC) ("respondent-based"), the Child and Adolescent Psychiatric Assessment (CAPA) ("interviewer-based"), and the Developmen ... Full text Link to item Cite

Evaluating the predictive validity of suicidal intent and medical lethality in youth.

Journal Article J Consult Clin Psychol · April 2012 OBJECTIVES: To examine whether suicidal intent and medical lethality of past suicide attempts are predictive of future attempts, the association between intent and lethality, and the consistency of these characteristics across repeated attempts among youth ... Full text Link to item Cite

The developmental epidemiology of anxiety disorders: Phenomenology, prevalence, and comorbidity

Chapter · January 1, 2011 In this chapter we review the prevalence and comorbidity of anxiety disorders in general, and where possible the specifics of separation anxiety disorder (SAD), generalized anxiety disorder (GAD), specific phobias, panic, social phobia, and panic disorder. ... Full text Cite

Longitudinal dimensionality of adolescent psychopathology: testing the differentiation hypothesis.

Journal Article J Child Psychol Psychiatry · August 2010 BACKGROUND: The differentiation hypothesis posits that the underlying liability distribution for psychopathology is of low dimensionality in young children, inflating diagnostic comorbidity rates, but increases in dimensionality with age as latent syndrome ... Full text Link to item Cite

Association of family income supplements in adolescence with development of psychiatric and substance use disorders in adulthood among an American Indian population.

Journal Article JAMA · May 19, 2010 CONTEXT: In a natural experiment in which some families received income supplements, prevalence of adolescent behavioral symptoms decreased significantly. These adolescents are now young adults. OBJECTIVE: To examine the effects of income supplements in ad ... Full text Link to item Cite

Trait anger, anger expression, and suicide attempts among adolescents and young adults: a prospective study.

Journal Article J Clin Child Adolesc Psychol · September 2009 Previous studies of the relationship between anger, anger expression, and suicidal behavior have been largely cross-sectional and have yielded mixed findings. In a prospective, naturalistic study, we examined how trait anger and anger expression influenced ... Full text Link to item Cite

Children of probationers in the child welfare system and their families

Journal Article Journal of Child and Family Studies · April 1, 2009 This study describes changes over a 36-month period in the lives of children of probationers who were subjects of reports of maltreatment. Data on a nationally representative sample of reported victims of maltreatment were used to examine probationer-paren ... Full text Cite

Psychiatric diagnoses as contemporaneous risk factors for suicide attempts among adolescents and young adults: developmental changes.

Journal Article J Consult Clin Psychol · April 2009 The purpose of this prospective, naturalistic study was to examine the relationships between suicide attempts and contemporaneous psychiatric disorders, and developmental changes in these relationships from adolescence to young adulthood. The sample consis ... Full text Link to item Cite

Differences in patterns of maternal arrest and the parent, family, and child problems encountered in working with families

Journal Article Children and Youth Services Review · February 1, 2008 The information reported in this article is based on data from the National Survey of Child and Adolescent Well-being (NSCAW), a study of a representative sample of children who were subjects of reports of maltreatment. Details of mothers' arrest histories ... Full text Cite

What do childhood anxiety disorders predict?

Journal Article J Child Psychol Psychiatry · December 2007 BACKGROUND: Few longitudinal studies of child and adolescent psychopathology have examined the links between specific childhood anxiety disorders and adolescent psychiatric disorder. In this paper we test the predictive specificity of separation anxiety di ... Full text Link to item Cite

Improving attention-deficit/hyperactivity disorder treatment outcomes through use of a collaborative consultation treatment service by community-based pediatricians: a cluster randomized trial.

Journal Article Arch Pediatr Adolesc Med · September 2007 OBJECTIVE: To test whether adoption of a collaborative consultative service model results in improved patient outcomes. DESIGN: Twelve pediatric practices were randomly assigned to receive access to collaborative consultative services or to a control group ... Full text Link to item Cite

Prediction from low birth weight to female adolescent depression: a test of competing hypotheses.

Journal Article Arch Gen Psychiatry · March 2007 CONTEXT: Low birth weight (LBW) predicts later-onset hypertension and diabetes mellitus. Its role as a predictor of depression is unclear. OBJECTIVES: To examine whether LBW predicts depression in male and female children and adolescents and to compare the ... Full text Link to item Cite

Differences among children whose mothers have been in contact with the criminal justice system

Journal Article Women and Criminal Justice · 2007 In order to effectively help children whose mothers become involved with the criminal justice system, it is important to understand their differing needs. To that end, the analyses described in this article explore the heterogeneity in parent and family ri ... Full text Cite

Reading problems, psychiatric disorders, and functional impairment from mid- to late adolescence.

Journal Article J Am Acad Child Adolesc Psychiatry · January 2007 OBJECTIVE: To examine psychiatric morbidity and functional impairment of adolescents with and without poor reading skills during mid- to late adolescence. METHOD: The sample consisted of 188 adolescents, 94 with poor reading skills and 94 with typical read ... Full text Link to item Cite

Is there an epidemic of child or adolescent depression?

Journal Article J Child Psychol Psychiatry · December 2006 BACKGROUND: Both the professional and the general media have recently published concerns about an 'epidemic' of child and adolescent depression. Reasons for this concern include (1) increases in antidepressant prescriptions, (2) retrospective recall by suc ... Full text Link to item Cite

Bayesian semi-parametric ROC analysis.

Journal Article Stat Med · November 30, 2006 Featured Publication This paper describes a semi-parametric Bayesian approach for estimating receiver operating characteristic (ROC) curves based on mixtures of Dirichlet process priors (MDP). We address difficulties in modelling the underlying distribution of screening scores ... Full text Link to item Cite

Lifetime trauma exposure in veterans with military-related posttraumatic stress disorder: association with current symptomatology.

Journal Article J Clin Psychiatry · September 2006 OBJECTIVE: This study examined whether trauma exposure before, during, and/or after military service contributed to current levels of post-traumatic stress disorder (PTSD) and adjustment. Further, we investigated whether trauma exposure before military ser ... Full text Link to item Cite

Test-Retest Reliability of the Preschool Age Psychiatric Assessment (PAPA).

Journal Article J Am Acad Child Adolesc Psychiatry · May 2006 OBJECTIVE: To examine the test-retest reliability of a new interviewer-based psychiatric diagnostic measure (the Preschool Age Psychiatric Assessment) for use with parents of preschoolers aged 2 to 5 years. METHOD: A total of 1,073 parents of children atte ... Full text Link to item Cite

Application of Bayesian modeling of autologous antibody responses against ovarian tumor-associated antigens to cancer detection.

Journal Article Cancer Res · February 1, 2006 Featured Publication Biomarkers for early detection of epithelial ovarian cancer (EOC) are urgently needed. Patients can generate antibodies to tumor-associated antigens (TAAs). We tested multiplex detection of antibodies to candidate ovarian TAAs and statistical modeling for ... Full text Link to item Cite

The Life Trajectory Interview for Youth (LTI-Y): method development and psychometric properties of an instrument to assess life-course models and achievement.

Journal Article Int J Methods Psychiatr Res · 2006 This paper describes the rationale, development and psychometric properties of the Life Trajectory Interview for Youth (LTI-Y), an instrument designed to assess cognitive models of the life course and life-course achievement. This method was developed over ... Full text Link to item Cite

Application of Bayesian inference using Gibbs sampling to item-response theory modeling of multi-symptom genetic data.

Journal Article Behav Genet · November 2005 Featured Publication Several "genetic" item-response theory (IRT) models are fitted to the responses of 1086 adolescent female twins to the 33 multi-category item Mood and Feeling Questionnaire relating to depressive symptomatology in adolescence. A Markov-chain Monte Carlo (M ... Full text Link to item Cite

Immediate antecedents of cigarette smoking in smokers with and without posttraumatic stress disorder: a preliminary study.

Journal Article Exp Clin Psychopharmacol · August 2005 Using ambulatory methods for 1 day of monitoring, the authors of this study investigated the association between smoking and situational cues in 63 smokers with posttraumatic stress disorder (PTSD) and 32 smokers without PTSD. Generalized estimating equati ... Full text Link to item Cite

Distant Trauma: A prospective study of the effects of september 11th on young adults in North Carolina

Journal Article Applied Developmental Science · October 1, 2004 In 2001, 730 young adults (aged 19–21) were given a detailed assessment as part of an ongoing longitudinal, epidemiological study of the development of psychiatric disorders across childhood and adolescence. Each participant had been interviewed up to 6 ti ... Full text Cite

Genetic and environmental influences on the relative timing of pubertal change.

Journal Article Twin Res · October 2004 Featured Publication A multicategory item-response theory model was developed to characterize developmental changes in three items relating to the assessment of puberty in adolescent twin girls and boys. The model allowed for the fixed effects of age on probability of endorsin ... Full text Link to item Cite

Effects of age at first substance use and psychiatric comorbidity on the development of substance use disorders.

Journal Article Drug Alcohol Depend · September 6, 2004 Featured Publication In this paper, we examine the effects of age at first substance use, and history of psychiatric disorders, on the development of substance use disorder (SUD) by age 16. We use a prospective, longitudinal design to disaggregate the effects of age at first u ... Full text Link to item Cite

Resolving multiple epigenetic pathways to adolescent depression.

Journal Article J Child Psychol Psychiatry · October 2003 Featured Publication BACKGROUND: Genotype x environment interaction (G x E) arises when genes influence sensitivity to the environment. G x E is easily recognized in experimental organisms that permit randomization of genotypes over fixed environmental treatments. Genotype-env ... Full text Link to item Cite

Relations between Continuous Performance Test performance measures and ADHD behaviors.

Journal Article J Abnorm Child Psychol · October 2003 The Conners' Continuous Performance Test (CPT) is a neuropsychological task that has repeatedly been shown to differentiate ADHD from normal groups. Several variables may be derived from the Conners' CPT including errors of omission and commission, mean hi ... Full text Link to item Cite

Prevalence and development of psychiatric disorders in childhood and adolescence.

Journal Article Arch Gen Psychiatry · August 2003 BACKGROUND: This longitudinal community study assessed the prevalence and development of psychiatric disorders from age 9 through 16 years and examined homotypic and heterotypic continuity. METHODS: A representative population sample of 1420 children aged ... Full text Link to item Cite

Markov Chain Monte Carlo approaches to analysis of genetic and environmental components of human developmental change and G x E interaction.

Journal Article Behav Genet · May 2003 Featured Publication The linear structural model has provided the statistical backbone of the analysis of twin and family data for 25 years. A new generation of questions cannot easily be forced into the framework of current approaches to modeling and data analysis because the ... Full text Link to item Cite

Obesity and psychiatric disorder: developmental trajectories.

Journal Article Pediatrics · April 2003 OBJECTIVES: To identify age-related trajectories of obesity from childhood into adolescence, and to test the association of these trajectories with the development of psychiatric disorders (conduct disorder, oppositional defiant disorder, attention-deficit ... Full text Link to item Cite

Depression scale scores in 8-17-year-olds: effects of age and gender.

Journal Article J Child Psychol Psychiatry · November 2002 BACKGROUND: The excess of unipolar depression in females emerges in adolescence. However, studies of age effects on depression scale scores have produced divergent estimates of changes from childhood to adolescence. METHOD: We explored possible reasons for ... Full text Link to item Cite

Psychiatric disorder, impairment, and service use in rural African American and white youth.

Journal Article Arch Gen Psychiatry · October 2002 Featured Publication BACKGROUND: The Caring for Children in the Community Study examined the prevalence of DSM-IV psychiatric disorders and correlates of mental health service use in rural African American and white youth. METHODS: Four thousand five hundred youth aged 9 to 17 ... Full text Link to item Cite

The prevalence of potentially traumatic events in childhood and adolescence.

Journal Article J Trauma Stress · April 2002 This paper examines exposure to potentially traumatic events from middle childhood through adolescence, and vulnerability to such exposure. Analyses are based on the first 4 annual waves of data from a longitudinal general population study of youth in west ... Full text Link to item Cite

Epidemiology of psychiatric disability in childhood and adolescence.

Journal Article J Child Psychol Psychiatry · October 2001 The goal of the study was to ascertain the factor structure and prevalence of psychiatric disability in children and adolescents in relation to demographic variables and diagnosis. A representative sample of 1,420 children (9-13 years) from 11 countries in ... Full text Link to item Cite

Bayesian analyses of longitudinal binary data using Markov regression models of unknown order.

Journal Article Stat Med · March 15, 2001 Featured Publication We present non-homogeneous Markov regression models of unknown order as a means to assess the duration of autoregressive dependence in longitudinal binary data. We describe a subject's transition probability evolving over time using logistic regression mod ... Full text Link to item Cite

Simulation-based designs for accelerated life tests

Journal Article Journal of Statistical Planning and Inference · October 1, 2000 In this paper we present a Bayesian decision theoretic approach to the design of accelerated life tests (ALT). We discuss computational issues regarding the evaluation of expectation and optimization steps in the solution of the decision problem. We illust ... Full text Cite

Stimulant treatment for children: a community perspective.

Journal Article J Am Acad Child Adolesc Psychiatry · August 2000 Featured Publication OBJECTIVE: To examine the use of prescribed stimulants in relation to research diagnoses of attention-deficit hyperactivity disorder (ADHD) in a community sample of children. METHOD: Data from 4 annual waves of interviews with 9- to 16-year-olds from the G ... Full text Link to item Cite

Effectiveness of nonresidential specialty mental health services for children and adolescents in the "real world".

Journal Article J Am Acad Child Adolesc Psychiatry · February 2000 OBJECTIVE: Although many studies demonstrate the efficacy of a variety of treatments for child and adolescent psychiatric disorders, studies showing the effectiveness of such treatments in ordinary clinical settings have not been forthcoming. This report p ... Full text Link to item Cite

Bayesian inference for prevalence in longitudinal two-phase studies.

Journal Article Biometrics · December 1999 Featured Publication We consider Bayesian inference and model selection for prevalence estimation using a longitudinal two-phase design in which subjects initially receive a low-cost screening test followed by an expensive diagnostic test conducted on several occasions. The ch ... Full text Link to item Cite

Development of psychiatric comorbidity with substance abuse in adolescents: effects of timing and sex.

Journal Article J Clin Child Psychol · September 1999 Examined the impact of childhood psychiatric disorders on the prevalence and timing of substance use and abuse and tested for sex differences. A representative population sample of 1,420 children, ages 9, 11, and 13 at intake, were interviewed annually. Am ... Full text Link to item Cite

Pubertal changes in hormone levels and depression in girls.

Journal Article Psychol Med · September 1999 BACKGROUND: Throughout their reproductive years, women suffer from a higher prevalence of depression than men. Before puberty, however, this is not the case. In an earlier study, we found that reaching Tanner Stage III of puberty was associated with increa ... Full text Link to item Cite

Somatic complaints and psychopathology in children and adolescents: stomach aches, musculoskeletal pains, and headaches.

Journal Article J Am Acad Child Adolesc Psychiatry · July 1999 OBJECTIVE: To examine the associations of somatic complaints with DSM-III-R-defined depression, anxiety disorders, conduct disorder, oppositional defiant disorder, and attention-deficit hyperactivity disorder in a population-based sample of children and ad ... Full text Link to item Cite

Impaired but undiagnosed.

Journal Article J Am Acad Child Adolesc Psychiatry · February 1999 OBJECTIVE: To investigate the prevalence and outcomes of individuals with psychosocial impairment not meeting DSM-III-R criteria for any of 29 well-defined disorders and to suggest operational definitions for not otherwise specified (NOS) diagnoses and V c ... Full text Link to item Cite

Comorbidity.

Journal Article J Child Psychol Psychiatry · January 1999 We review recent research on the prevalence, causes, and effects of diagnostic comorbidity among the most common groups of child and adolescent psychiatric disorders; anxiety disorders, depressive disorders, attention deficit hyperactivity disorders, oppos ... Link to item Cite

Optimal Bayesian two-phase designs

Journal Article Journal of Statistical Planning and Inference · January 5, 1998 In this paper we present a Bayesian decision theoretic approach to the two-phase design problem. The solution of such sequential decision problems is usually difficult to obtain because of their reliance on preposterior analysis. In overcoming this problem ... Full text Cite

Bayesian computations for a class of reliability growth models

Journal Article Technometrics · January 1, 1998 In this article, we consider the development and analysis of both attribute- and variable-data reliability growth models from a Bayesian perspective. We begin with an overview of a Bayesian attribute-data reliability growth model and illustrate how this mo ... Full text Cite

Bayesian inference in two-phase prevalence studies.

Journal Article Stat Med · May 30, 1997 Featured Publication This paper discusses Bayesian methods for the assessment of the prevalence of a disorder based on data from a two-phase design with a short screening instrument administered at the first phase followed by an in-depth diagnostic instrument given at the seco ... Full text Link to item Cite

Psychiatric disorders among American Indian and white youth in Appalachia: the Great Smoky Mountains Study.

Journal Article Am J Public Health · May 1997 OBJECTIVES: This study examined prevalence of psychiatric disorders, social and family risk factors for disorders, and met and unmet needs for mental health care among Appalachian youth. METHODS: All 9-, 11-, and 13-year-old American Indian children in an ... Full text Link to item Cite

Development of substance use and psychiatric comorbidity in an epidemiologic study of white and American Indian young adolescents the Great Smoky Mountains Study.

Journal Article Drug Alcohol Depend · March 14, 1997 The progression of substance use and the patterns of comorbidity of substance use and psychiatric disorders are explored prospectively in young adolescents enrolled in the Great Smoky Mountains Study. This study is an epidemiologic study of white and Ameri ... Full text Link to item Cite

Insurance coverage and mental health services use by adolescents with serious emotional disturbance

Journal Article Journal of Child and Family Studies · January 1, 1997 This paper examines the relationships between insurance coverage, need, and mental health services in a community-based sample of 1,015youths who were 9, 11, and 13 years old at the beginning of the study. They were followed over a two-year period. A stron ... Full text Cite

Boundary-mode approximations for posterior expectations

Journal Article Journal of Statistical Planning and Inference · January 1, 1997 Laplacian approximations to posterior expectations of smooth functions of parameters are considered when the posterior mode lies on the boundary of the parameter space. Since posterior expectations can be written as ratios of integrals, a simple approximat ... Full text Cite

The Great Smoky Mountains Study of Youth. Goals, design, methods, and the prevalence of DSM-III-R disorders.

Journal Article Arch Gen Psychiatry · December 1996 BACKGROUND: The Great Smoky Mountains Study of youth focuses on the relationship between the development of psychiatric disorder and the need for and use of mental health services. METHODS: A multistage, overlapping cohorts design was used, in which 4500 o ... Full text Link to item Cite

The Great Smoky Mountains Study of Youth. Functional impairment and serious emotional disturbance.

Journal Article Arch Gen Psychiatry · December 1996 BACKGROUND: Federal regulations require states to estimate the prevalence and incidence of serious emotional disturbance (SED) in children, defined as a DSM-III-R diagnosis in the presence of impaired functioning in 1 or more areas. We reviewed the publish ... Full text Link to item Cite

Precision, reliability and accuracy in the dating of symptom onsets in child and adolescent psychopathology.

Journal Article J Child Psychol Psychiatry · September 1996 Dates of onset of psychiatric symptoms are required in determining whether diagnostic criteria are met for a number of disorders and for a variety of research questions. However, little attention has been paid to the precision and reliability of their reca ... Full text Link to item Cite

Bayesian curve fitting using multivariate normal mixtures

Journal Article Biometrika · January 1, 1996 Problems of regression smoothing and curve fitting are addressed via predictive inference in a flexible class of mixture models. Multidimensional density estimation using Dirichlet mixture models provides the theoretical basis for semi-parametric regressio ... Full text Cite

Disappearing Depression in a Population Sample of Boys

Journal Article Journal of Emotional and Behavioral Disorders · January 1, 1996 Although there is evidence that rules of depressive disorders increase during adolescence in girls, the data on the effects of age on depression in boys have been contradictory. In order to shed further light on this issue, the Short Mood and Feelings Ques ... Full text Cite

Children's mental health service use across service sectors.

Journal Article Health Aff (Millwood) · 1995 This DataWatch explores the roles of human service sectors (mental health, education, health, child welfare, and juvenile justice) in providing mental health services for children. The data are from the first wave of the Great Smoky Mountains Study of Yout ... Full text Link to item Cite

Laplace approximations for posterior expectations when the mode occurs at the boundary of the parameter space

Journal Article Journal of the American Statistical Association · January 1, 1994 This article gives asymptotic expansions for posterior expectations when the mode is on the boundary of the parameter space. The idea, based on the divergence theorem, is to reduce the high-dimensional integrals over the parameters space to surface integra ... Full text Cite

ADAPTING SUBREGION-ADAPTIVE INTEGRATION SOFTWARE TO PROBLEMS IN BAYESIAN-INFERENCE

Conference COMPUTING SCIENCE AND STATISTICS : VOL 24 · January 1, 1992 Link to item Cite