Scholars@Duke
Cecil Orm Borel III

Cecil Orm Borel III

Professor Emeritus
Anesthesiology, Neuroanesthesia
borel001@mc.duke.edu
Box 3094 Med Ctr, Durham, NC 27710
3413D Hosp North, Durham, NC 27710
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Selected Publications

A novel application for bolus remifentanil: blunting the hemodynamic response to Mayfield skull clamp placement.

Journal Article Curr Med Res Opin · February 2014 OBJECTIVE: Neurosurgery often requires skull immobilization with a Mayfield clamp, which often causes brief intense nociceptive stimulation, hypertension and tachycardia. Blunting this response may help prevent increased intracranial pressure, cerebral ane ... Full text Link to item Cite

Neuroprotective effect of curcumin in an experimental rat model of subarachnoid hemorrhage.

Journal Article Anesthesiology · December 2011 BACKGROUND: Subarachnoid hemorrhage (SAH) causes a high mortality rate and morbidity. It was suggested that oxidant stress plays an important role in neuronal injury after SAH. Therefore, we assessed the effect of curcumin on reducing cerebral vasospasm an ... Full text Link to item Cite

A comparison of the combination of aprepitant and dexamethasone versus the combination of ondansetron and dexamethasone for the prevention of postoperative nausea and vomiting in patients undergoing craniotomy.

Journal Article Anesth Analg · April 2011 BACKGROUND: Postoperative nausea and vomiting (PONV) occur commonly after craniotomy. In patients receiving prophylaxis with ondansetron and dexamethasone, vomiting occurred in 45% of patients at 48 hours. In addition to causing patient discomfort, the phy ... Full text Link to item Cite

Temporal changes in glutamate, glutamate transporters, basilar arteries wall thickness, and neuronal variability in an experimental rat model of subarachnoid hemorrhage.

Journal Article Anesth Analg · March 2011 BACKGROUND: Glutamate and glutamate transporters (GTs) (including glutamate/aspartate transporter, glutamate transporter-1, and excitatory amino acid carrier 1) have important roles in the pathogenesis of ischemic neurological injury. The changes in glutam ... Full text Link to item Cite

Adenosine-induced transient asystole for intracranial aneurysm surgery: a retrospective review.

Journal Article J Neurosurg Anesthesiol · January 2011 UNLABELLED: BRIEF SUMMARY: We describe the use of adenosine-induced cardiac arrest to facilitate intracranial aneurysm clip ligation. BACKGROUND: Cerebral aneurysms are highly variable which may result in difficult surgical exposure for clip ligation in se ... Full text Link to item Cite

Transient adenosine-induced asystole during the surgical treatment of anterior circulation cerebral aneurysms: technical note.

Journal Article Neurosurgery · December 2010 BACKGROUND: Transient adenosine-induced asystole is a reliable method for producing a short period of relative hypotension during surgical and endovascular procedures. Although the technique has been described in the endovascular treatment of brain arterio ... Full text Link to item Cite

A comparison of 3% hypertonic saline and mannitol for brain relaxation during elective supratentorial brain tumor surgery.

Journal Article Anesth Analg · March 1, 2010 BACKGROUND: In this study, we compared the effects of 3% hypertonic saline (HTS) and 20% mannitol on brain relaxation during supratentorial brain tumor surgery, intensive care unit (ICU) stays, and hospital days. METHODS: This prospective, randomized, and ... Full text Link to item Cite

Myasthenia Gravis

Chapter · January 1, 2010 Full text Cite

Simvastatin treatment duration and cognitive preservation in experimental subarachnoid hemorrhage.

Journal Article J Neurosurg Anesthesiol · October 2009 Cognitive dysfunction, a significant complication after subarachnoid hemorrhage (SAH), affects up to 60% of survivors. We hypothesized that oral simvastatin would improve vestibulomotor function and reduce cognitive dysfunction after experimental SAH in th ... Full text Link to item Cite

Long-term cognitive dysfunction following experimental subarachnoid hemorrhage: new perspectives.

Journal Article Exp Neurol · October 2008 Cognitive dysfunction is increasingly recognized as a significant long-term complication following subarachnoid hemorrhage (SAH), affecting up to 60% of survivors. We proposed to determine the incidence and explore potential mechanisms of cognitive dysfunc ... Full text Link to item Cite

[Late outcome of 89 patients with soft-tissue sarcomas treated by surgery and three different radiotherapy schedules]

Journal Article Cancer radiothérapie : journal de la Société française de radiothérapie oncologique, Fra · December 2007 PURPOSE: To evaluate the outcome of patients treated for soft tissue sarcoma using three different post-operative radiotherapy schedules. METHODS AND MATERIALS: Between 1990 and 2003, 89 patients (median age 50.8 years) presenting with soft tissue sarcoma ... Cite

[Fulminant alveolar hemorrhage: Evolution of giant cell arteritis to ANCA-positive vasculitis?]

Journal Article Rev Med Interne · September 2007 INTRODUCTION: Giant cell arteritis (GCA) is a granulomatous vasculitis of the large and medium size vessels with a remarkable sensitivity to corticosteroids, although it may be dependent to therapy. In rare cases, a vasculitis of the medium or small-size v ... Cite

Human microRNA-155 on chromosome 21 differentially interacts with its polymorphic target in the AGTR1 3' untranslated region: a mechanism for functional single-nucleotide polymorphisms related to phenotypes.

Journal Article American journal of human genetics · August 2007 Animal microRNAs (miRNAs) regulate gene expression through base pairing to their targets within the 3' untranslated region (UTR) of protein-coding genes. Single-nucleotide polymorphisms (SNPs) located within such target sites can affect miRNA regulation. W ... Cite

Docetaxel plus gemcitabine in recurrent and/or metastatic squamous cell carcinoma of the head and neck: a phase II multicenter study.

Journal Article American journal of clinical oncology · June 2007 OBJECTIVES: This phase II study was conducted to assess the efficacy of docetaxel plus gemcitabine in locally recurrent and/or metastatic squamous cell carcinoma of the head and neck. PATIENTS AND METHODS: Forty patients with pharynx or larynx cancer were ... Cite

[Rituximab induced remission of pemphigus vulgaris: 2 cases]

Journal Article La Revue de médecine interne / fondée ... par la Société nationale francaise de médecine interne, Fra · April 2007 INTRODUCTION: Pemphigus vulgaris frequently requires corticoids and immuno-suppressive drugs. The disease and the side effects of the drugs severely affect the quality of life, and sometime the vital prognosis of the patients. Other treatments than cortico ... Cite

Towards a virtual fruit focusing on quality: modelling features and potential uses.

Journal Article Journal of experimental botany · 2007 The fruit is a hierarchically organized organ composed of cells from different tissues. Its quality, defined by traits such as fruit size and composition, is the result of a complex chain of biological processes. These processes involve exchanges (transpir ... Cite

Use of high frequency oscillatory ventilation (HFOV) in neurocritical care patients.

Journal Article Neurocrit Care · 2007 INTRODUCTION: Adult respiratory distress syndrome (ARDS) can be a common problem associated with the treatment of acute brain injury. High frequency oscillatory ventilation (HFOV) is a developing therapy for the treatment of ARDS in adult patients that can ... Full text Link to item Cite

Dissociation between vasospasm and functional improvement in a murine model of subarachnoid hemorrhage.

Journal Article Neurosurg Focus · September 15, 2006 OBJECT: The efficacy of nimodipine was examined in a murine model of subarachnoid hemorrhage (SAH). End points included the diameter of the lumen of the middle cerebral artery (MCA) and behavioral outcome. An apolipoprotein E (apoE)-mimetic peptide, acetyl ... Full text Link to item Cite

Anesthetic management of an AAI pacemaker patient with paroxysmal atrial fibrillation during colorectal surgery.

Journal Article J Clin Anesth · August 2006 Perioperative management of patients with cardiac pacemakers may be challenging because of the increasing sophistication of these devices. We report a case of a patient with paroxysmal atrial fibrillation (PAF) and with a permanent AAIR (bipolar atrial-inh ... Full text Link to item Cite

A novel application for bolus remifentanil: blunting the hemodynamic response to Mayfield skull clamp placement.

Journal Article Curr Med Res Opin · February 2014 OBJECTIVE: Neurosurgery often requires skull immobilization with a Mayfield clamp, which often causes brief intense nociceptive stimulation, hypertension and tachycardia. Blunting this response may help prevent increased intracranial pressure, cerebral ane ... Full text Link to item Cite

Neuroprotective effect of curcumin in an experimental rat model of subarachnoid hemorrhage.

Journal Article Anesthesiology · December 2011 BACKGROUND: Subarachnoid hemorrhage (SAH) causes a high mortality rate and morbidity. It was suggested that oxidant stress plays an important role in neuronal injury after SAH. Therefore, we assessed the effect of curcumin on reducing cerebral vasospasm an ... Full text Link to item Cite

A comparison of the combination of aprepitant and dexamethasone versus the combination of ondansetron and dexamethasone for the prevention of postoperative nausea and vomiting in patients undergoing craniotomy.

Journal Article Anesth Analg · April 2011 BACKGROUND: Postoperative nausea and vomiting (PONV) occur commonly after craniotomy. In patients receiving prophylaxis with ondansetron and dexamethasone, vomiting occurred in 45% of patients at 48 hours. In addition to causing patient discomfort, the phy ... Full text Link to item Cite

Temporal changes in glutamate, glutamate transporters, basilar arteries wall thickness, and neuronal variability in an experimental rat model of subarachnoid hemorrhage.

Journal Article Anesth Analg · March 2011 BACKGROUND: Glutamate and glutamate transporters (GTs) (including glutamate/aspartate transporter, glutamate transporter-1, and excitatory amino acid carrier 1) have important roles in the pathogenesis of ischemic neurological injury. The changes in glutam ... Full text Link to item Cite

Adenosine-induced transient asystole for intracranial aneurysm surgery: a retrospective review.

Journal Article J Neurosurg Anesthesiol · January 2011 UNLABELLED: BRIEF SUMMARY: We describe the use of adenosine-induced cardiac arrest to facilitate intracranial aneurysm clip ligation. BACKGROUND: Cerebral aneurysms are highly variable which may result in difficult surgical exposure for clip ligation in se ... Full text Link to item Cite

Transient adenosine-induced asystole during the surgical treatment of anterior circulation cerebral aneurysms: technical note.

Journal Article Neurosurgery · December 2010 BACKGROUND: Transient adenosine-induced asystole is a reliable method for producing a short period of relative hypotension during surgical and endovascular procedures. Although the technique has been described in the endovascular treatment of brain arterio ... Full text Link to item Cite

A comparison of 3% hypertonic saline and mannitol for brain relaxation during elective supratentorial brain tumor surgery.

Journal Article Anesth Analg · March 1, 2010 BACKGROUND: In this study, we compared the effects of 3% hypertonic saline (HTS) and 20% mannitol on brain relaxation during supratentorial brain tumor surgery, intensive care unit (ICU) stays, and hospital days. METHODS: This prospective, randomized, and ... Full text Link to item Cite

Myasthenia Gravis

Chapter · January 1, 2010 Full text Cite

Simvastatin treatment duration and cognitive preservation in experimental subarachnoid hemorrhage.

Journal Article J Neurosurg Anesthesiol · October 2009 Cognitive dysfunction, a significant complication after subarachnoid hemorrhage (SAH), affects up to 60% of survivors. We hypothesized that oral simvastatin would improve vestibulomotor function and reduce cognitive dysfunction after experimental SAH in th ... Full text Link to item Cite

Long-term cognitive dysfunction following experimental subarachnoid hemorrhage: new perspectives.

Journal Article Exp Neurol · October 2008 Cognitive dysfunction is increasingly recognized as a significant long-term complication following subarachnoid hemorrhage (SAH), affecting up to 60% of survivors. We proposed to determine the incidence and explore potential mechanisms of cognitive dysfunc ... Full text Link to item Cite

[Late outcome of 89 patients with soft-tissue sarcomas treated by surgery and three different radiotherapy schedules]

Journal Article Cancer radiothérapie : journal de la Société française de radiothérapie oncologique, Fra · December 2007 PURPOSE: To evaluate the outcome of patients treated for soft tissue sarcoma using three different post-operative radiotherapy schedules. METHODS AND MATERIALS: Between 1990 and 2003, 89 patients (median age 50.8 years) presenting with soft tissue sarcoma ... Cite

[Fulminant alveolar hemorrhage: Evolution of giant cell arteritis to ANCA-positive vasculitis?]

Journal Article Rev Med Interne · September 2007 INTRODUCTION: Giant cell arteritis (GCA) is a granulomatous vasculitis of the large and medium size vessels with a remarkable sensitivity to corticosteroids, although it may be dependent to therapy. In rare cases, a vasculitis of the medium or small-size v ... Cite

Human microRNA-155 on chromosome 21 differentially interacts with its polymorphic target in the AGTR1 3' untranslated region: a mechanism for functional single-nucleotide polymorphisms related to phenotypes.

Journal Article American journal of human genetics · August 2007 Animal microRNAs (miRNAs) regulate gene expression through base pairing to their targets within the 3' untranslated region (UTR) of protein-coding genes. Single-nucleotide polymorphisms (SNPs) located within such target sites can affect miRNA regulation. W ... Cite

Docetaxel plus gemcitabine in recurrent and/or metastatic squamous cell carcinoma of the head and neck: a phase II multicenter study.

Journal Article American journal of clinical oncology · June 2007 OBJECTIVES: This phase II study was conducted to assess the efficacy of docetaxel plus gemcitabine in locally recurrent and/or metastatic squamous cell carcinoma of the head and neck. PATIENTS AND METHODS: Forty patients with pharynx or larynx cancer were ... Cite

[Rituximab induced remission of pemphigus vulgaris: 2 cases]

Journal Article La Revue de médecine interne / fondée ... par la Société nationale francaise de médecine interne, Fra · April 2007 INTRODUCTION: Pemphigus vulgaris frequently requires corticoids and immuno-suppressive drugs. The disease and the side effects of the drugs severely affect the quality of life, and sometime the vital prognosis of the patients. Other treatments than cortico ... Cite

Towards a virtual fruit focusing on quality: modelling features and potential uses.

Journal Article Journal of experimental botany · 2007 The fruit is a hierarchically organized organ composed of cells from different tissues. Its quality, defined by traits such as fruit size and composition, is the result of a complex chain of biological processes. These processes involve exchanges (transpir ... Cite

Use of high frequency oscillatory ventilation (HFOV) in neurocritical care patients.

Journal Article Neurocrit Care · 2007 INTRODUCTION: Adult respiratory distress syndrome (ARDS) can be a common problem associated with the treatment of acute brain injury. High frequency oscillatory ventilation (HFOV) is a developing therapy for the treatment of ARDS in adult patients that can ... Full text Link to item Cite

Dissociation between vasospasm and functional improvement in a murine model of subarachnoid hemorrhage.

Journal Article Neurosurg Focus · September 15, 2006 OBJECT: The efficacy of nimodipine was examined in a murine model of subarachnoid hemorrhage (SAH). End points included the diameter of the lumen of the middle cerebral artery (MCA) and behavioral outcome. An apolipoprotein E (apoE)-mimetic peptide, acetyl ... Full text Link to item Cite

Anesthetic management of an AAI pacemaker patient with paroxysmal atrial fibrillation during colorectal surgery.

Journal Article J Clin Anesth · August 2006 Perioperative management of patients with cardiac pacemakers may be challenging because of the increasing sophistication of these devices. We report a case of a patient with paroxysmal atrial fibrillation (PAF) and with a permanent AAIR (bipolar atrial-inh ... Full text Link to item Cite

Phase I/II study of cetuximab in combination with cisplatin or carboplatin and fluorouracil in patients with recurrent or metastatic squamous cell carcinoma of the head and neck.

Journal Article J Clin Oncol · June 20, 2006 PURPOSE: This was an open, randomized, multicenter, phase I/II study to investigate the safety and tolerability of cetuximab in the first-line treatment of recurrent/metastatic squamous cell carcinoma of the head and neck (SCCHN). PATIENTS AND METHODS: Tre ... Full text Link to item Cite

Correlation between changes in regional cerebral blood flow and pain relief in complex regional pain syndrome type 1.

Journal Article Clin Nucl Med · June 2006 OBJECTIVE: Analyzing changes in regional cerebral blood flow (rCBF) with SPECT in complex regional pain syndrome type 1 (CRPS 1), formerly known as reflex sympathetic dystrophy, is an optimal method for evaluating effective pain relief. We attempted to inv ... Full text Link to item Cite

Effects of liver growth factors on hepadnavirus replication in chronically infected duck hepatocytes.

Journal Article J Hepatol · May 2006 BACKGROUND/AIMS: Duck hepatitis B virus (DHBV) replication is up-regulated by cell cycle during the early infection of primary duck but the effect of cell cycle on DHBV replication in chronically infected hepatocyte is not known. METHODS: Hepatocytes obtai ... Full text Link to item Cite

Penicillin resistance is not extrapolable to amoxicillin resistance in Streptococcus pneumoniae isolated from middle ear fluid in children with acute otitis media.

Journal Article Ann Otol Rhinol Laryngol · March 2006 OBJECTIVES: We evaluated the in vitro antibacterial activity of amoxicillin against penicillin-susceptible and -nonsusceptible Streptococcus pneumoniae strains isolated from children with acute otitis media (AOM). METHODS: Children more than 3 months of ag ... Full text Link to item Cite

Comparing the effects of minimal low-flow desflurane with that of semi-close high flow desflurane on perioperative cytokine response in patients undergoing gastrectomy.

Journal Article Acta Anaesthesiol Taiwan · March 2006 BACKGROUND: Anesthetic techniques may influence the perioperative cytokine response. We investigate two anesthetic techniques: minimal low-flow anesthesia (LFA) and semi-closed high flow anesthesia (HFA) with desflurane on the effect of cytokine response i ... Link to item Cite

Thromboelastography detects inadequate response to abciximab therapy during stent-assisted cerebral aneurysm coil embolization complicated by stroke.

Journal Article Neurocrit Care · 2006 INTRODUCTION: Thromboembolic stroke is the most common severe complication following coil embolization of intracerebral aneurysms, with a 5% incidence of permanent deficits. Despite heparin anticoagulation, rescue therapy with the platelet glycoprotein IIb ... Full text Link to item Cite

Preoperative cotreatment with dextromethorphan and ketorolac provides an enhancement of pain relief after laparoscopic-assisted vaginal hysterectomy.

Journal Article Clin J Pain · 2006 OBJECTIVES: Both N-methyl-D-aspartate receptor antagonists and nonsteroidal anti-inflammatory drugs have been demonstrated to produce better postoperative pain relief. The concept of multimodal analgesia has also been used for clinical pain management. The ... Full text Link to item Cite

Role of vascular mitogens in subarachnoid hemorrhage-associated cerebral vasculopathy.

Journal Article Neurocrit Care · 2006 INTRODUCTION: Cerebral vasculopathy may play an important role in the development of delayed cerebral ischemia following subarachnoid hemorrhage (SAH). Platelet-derived growth factor AB (PDGF-AB) and vascular endothelial growth factor (VEGF) released from ... Full text Link to item Cite

Combined general-epidural anesthesia decreases the desflurane requirement for equivalent A-line ARX index in colorectal surgery.

Journal Article Acta Anaesthesiol Scand · September 2005 BACKGROUND: The present study used the A-line ARX index, derived from auditory evoked potential measurements, to examine the effect of epidural lidocaine on the end-tidal concentration of desflurane during general anesthesia. METHODS: Thirty ASA I-II patie ... Full text Link to item Cite

Development of a new state-of-the-art beamline optimized for monochromatic single-crystal and powder X-ray diffraction under extreme conditions at the ESRF.

Journal Article J Synchrotron Radiat · September 2005 A new state-of-the art synchrotron beamline fully optimized for monochromatic X-ray diffraction at high pressure and high (or low) temperature is presented. In comparison with the old high-pressure beamline ID30, this new beamline exhibits outstanding perf ... Full text Link to item Cite

Prognostic indicators for survival in head and neck squamous cell carcinomas: analysis of a series of 621 cases.

Journal Article Head Neck · September 2005 BACKGROUND: We sought to study the influence of pT classification, pN status, tumor volume, and number of lymph nodes invaded on survival of patients with head and neck cancers to improve therapeutic indications. METHODS: This was a retrospective study of ... Full text Link to item Cite

A retrospective analysis of a remifentanil/propofol general anesthetic for craniotomy before awake functional brain mapping.

Journal Article Anesth Analg · August 2005 UNLABELLED: We performed this study to summarize drug dosing, physiologic responses, and anesthetic complications from an IV general anesthetic technique for patients undergoing craniotomy for awake functional brain mapping. Review of 98 procedures reveale ... Full text Link to item Cite

Different mechanisms preclude mutant CLDN14 proteins from forming tight junctions in vitro.

Journal Article Hum Mutat · June 2005 Mutations in claudin 14 (CLDN14) cause nonsyndromic DFNB29 deafness in humans. The analysis of a murine model indicated that this phenotype is associated with degeneration of hair cells, possibly due to cation overload. However, the mechanism linking these ... Full text Link to item Cite

Peutz-Jeghers LKB1 mutants fail to activate GSK-3beta, preventing it from inhibiting Wnt signaling.

Journal Article Mol Genet Genomics · April 2005 Peutz-Jeghers syndrome (PJS) is caused by germline mutations in the LKB1 gene, which encodes a serine-threonine kinase that regulates cell proliferation and polarity. This autosomal dominant disorder is characterized by mucocutaneous melanin pigmentation, ... Full text Link to item Cite

Postdural puncture headache with abdominal pain and diarrhea.

Journal Article Anesth Analg · March 2005 Dural puncture or a rent in the dura with prolonged cerebrospinal fluid leakage may cause noninfectious arachnoiditis and may be associated with urinary and fecal incontinence. Visceral dysfunction is common for patients with noninfectious arachnoiditis of ... Full text Link to item Cite

Analysis of the brain bioavailability of peripherally administered magnesium sulfate: A study in humans with acute brain injury undergoing prolonged induced hypermagnesemia.

Journal Article Crit Care Med · March 2005 OBJECTIVE: Based on preclinical investigations, magnesium sulfate (MgSO4) has gained interest as a neuroprotective agent. However, the ability of peripherally administered MgSO4 to penetrate the blood-brain barrier is limited in normal brain. The current s ... Full text Link to item Cite

The interaction effect of perioperative cotreatment with dextromethorphan and intravenous lidocaine on pain relief and recovery of bowel function after laparoscopic cholecystectomy.

Journal Article Anesth Analg · February 2005 Both dextromethorphan (DM) and IV lidocaine improve postoperative pain relief. In the present study, we evaluated the interaction of DM and IV lidocaine on pain management after laparoscopic cholecystectomy (LC). One-hundred ASA physical status I or II pat ... Full text Link to item Cite

Magnesium neuroprotection is limited in humans with acute brain injury.

Journal Article Neurocrit Care · 2005 Based on the results of preclinical models, magnesium sulfate (MgSO4) has gained attention as a putative neuroprotective agent. The negative results of a large-scale, randomized clinical trial using MgSO4 in acute stroke have tempered the initial enthusias ... Full text Link to item Cite

Treatment of cerebral vasospasm after subarachnoid hemorrhage--a review.

Journal Article Acta Anaesthesiol Taiwan · December 2004 Delayed cerebral ischemia as a result of cerebral vasospasm is the most common cause of death and disability after aneurysmal subarachnoid hemorrhage (SAH). It leads to death or permanent neurologic deficits in over 17-40% of SAH patients. The initial and ... Link to item Cite

Preincisional intravenous pentoxifylline attenuating perioperative cytokine response, reducing morphine consumption, and improving recovery of bowel function in patients undergoing colorectal cancer surgery.

Journal Article Anesth Analg · November 2004 Cytokine release during surgery can produce a long-lasting hyperalgesia. Thus, preoperatively-administered cytokine inhibitors might reduce the production of cytokines, decreasing central nervous system sensitization and improving the quality of postoperat ... Full text Link to item Cite

The effect of epidural clonidine on perioperative cytokine response, postoperative pain, and bowel function in patients undergoing colorectal surgery.

Journal Article Anesth Analg · August 2004 The postoperative period is associated with an increased production of cytokines, which augment pain sensitivity. We investigated the hypothesis that epidural clonidine premedication and postoperative patient-controlled epidural analgesia (PCEA) including ... Full text Link to item Cite

Cerebrospinal fluid rhinorrhea after thermometer insertion through the nose.

Journal Article Anesth Analg · August 2004 Cerebrospinal fluid (CSF) rhinorrhea is a rare clinical condition. Most leaks either are caused by traumatic head injury or are a complication of surgical procedures on the base of the skull. CSF rhinorrhea from nasal tube placement has been reported previ ... Full text Link to item Cite

ARF1 regulates Nef-induced CD4 degradation.

Journal Article Curr Biol · June 22, 2004 BACKGROUND: The HIV Nef protein downregulates CD4 through sequential connection with clathrin-coated pits and the COP1 coatomer, resulting in accelerated endocytosis and lysosomal targeting. RESULTS: Here we report that the small GTPase ARF1 controls the N ... Full text Link to item Cite

Neurogenic pulmonary edema during intracranial endovascular therapy.

Journal Article Neurocrit Care · 2004 Neurogenic pulmonary edema (NPE) is a well-known complication of acute brain injury. Neurogenic stunned myocardium (NSM) occurs clinically in a significant subset of patients with NPE. A 49-year-old woman developed refractory cerebral vasospasm requiring a ... Full text Link to item Cite

Comparative value of tumour grade, hormonal receptors, Ki-67, HER-2 and topoisomerase II alpha status as predictive markers in breast cancer patients treated with neoadjuvant anthracycline-based chemotherapy.

Journal Article Eur J Cancer · January 2004 The aim of this study was to evaluate the predictive value of five different biological factors in breast cancer patients treated with neoadjuvant anthracycline-based chemotherapy: (1) tumour grade scored according to the Elston-Ellis classification, (2) h ... Full text Link to item Cite

Do genetic make-up and growth manipulation affect tomato fruit size by cell number, or cell size and DNA endoreduplication?

Journal Article Ann Bot · September 2003 This work investigated the link between genetic and developmental controls of fruit size and composition. On two isogenic lines (CF12-C and CF14-L), differing by fruit weight and sugar content quantitative trait loci (QTLs) identified previously, basal and ... Full text Link to item Cite

Randomized multicentric study of perioperative chemotherapy with mitoxantrone in early breast cancer.

Journal Article Ann Surg Oncol · May 2003 BACKGROUND: To confirm the hypothesis that reducing the interval between surgery and adjuvant chemotherapy could improve prognosis, a randomized multicentric study of adjuvant perioperative chemotherapy (POC) in breast cancer was initiated. METHODS: A tota ... Full text Link to item Cite

Use of the peak troponin value to differentiate myocardial infarction from reversible neurogenic left ventricular dysfunction associated with aneurysmal subarachnoid hemorrhage.

Journal Article J Neurosurg · March 2003 OBJECT: Differentiating myocardial infarction (MI) from reversible neurogenic left ventricular dysfunction (stunned myocardium [SM]) associated with aneurysmal subarachnoid hemorrhage (SAH) is critical for early surgical intervention. The authors hypothesi ... Full text Link to item Cite

Possible role for vascular cell proliferation in cerebral vasospasm after subarachnoid hemorrhage.

Journal Article Stroke · February 2003 Featured Publication BACKGROUND AND PURPOSE: During vasospasm after subarachnoid hemorrhage (SAH), cerebral blood vessels show structural changes consistent with the actions of vascular mitogens. We measured platelet-derived vascular growth factors (PDGFs) in the cerebrospinal ... Link to item Cite

A phase II study of docetaxel-irinotecan combination in advanced pancreatic cancer.

Journal Article Hepatogastroenterology · 2003 BACKGROUND/AIMS: Chemotherapy provides dismal results in advanced pancreatic cancer patients, even when new compounds, such as gemcitabine, are used. Phase I studies of single-drug therapy with docetaxel or irinotecan suggested a response rate of about 15% ... Link to item Cite

High-dose, single-agent irinotecan as first-line therapy in the treatment of metastatic colorectal cancer.

Journal Article Cancer Chemother Pharmacol · November 2002 PURPOSE: The efficacy and safety of single-agent, high-dose irinotecan (CPT-11, Campto) 500 mg/m(2) every 3 weeks were investigated as first-line treatment for advanced colorectal cancer (CRC). PATIENTS AND METHODS: Patients were enrolled into the study to ... Full text Link to item Cite

A cis-acting sequence homologous to the yeast filamentation and invasion response element regulates expression of a pectinase gene from the bean pathogen Colletotrichum lindemuthianum.

Journal Article J Biol Chem · August 9, 2002 Phytopathogenic fungi secrete hydrolytic enzymes that degrade plant cell walls, notably pectinases. The signaling pathway(s) that control pectinase gene expression are currently unknown in filamentous fungi. Recently, the green fluorescent protein coding s ... Full text Link to item Cite

A randomized, double-blind comparison of ondansetron versus placebo for prevention of nausea and vomiting after infratentorial craniotomy.

Journal Article J Neurosurg Anesthesiol · April 2002 Featured Publication Ondansetron was compared with placebo for nausea and vomiting prophylaxis after fentanyl/isoflurane/relaxant anesthesia and infratentorial craniotomy. Eight milligrams intravenous ondansetron or vehicle was administered at skin closure. Nausea, emesis, and ... Full text Link to item Cite

Is the ABA concentration in the sap collected by pressurizing leaves relevant for analysing drought effects on stomata? Evidence from ABA-fed leaves of transgenic plants with modified capacities to synthesize ABA.

Journal Article J Exp Bot · February 2002 Most studies on the role of ABA in the stomatal response of the whole plant to drought rely on a good estimate of ABA concentration in xylem sap. In this report, varying volumes of sap (V(sap)) were collected by pressurizing leaves cut from several lines o ... Full text Link to item Cite

Multicentre phase II study of oxaliplatin as a single-agent in cisplatin/carboplatin +/- taxane-pretreated ovarian cancer patients.

Journal Article Ann Oncol · February 2002 BACKGROUND: This multicentre phase II open-label study evaluated safety and antitumour activity of oxaliplatin in cisplatin or carboplatin (cis/carboplatin) +/- taxane-pretreated advanced ovarian cancer (AOC) patients. PATIENTS AND METHODS: Forty-eight pat ... Full text Link to item Cite

Molecular characterization of CLPT1, a SEC4-like Rab/GTPase of the phytopathogenic fungus Colletotrichum lindemuthianum which is regulated by the carbon source.

Journal Article Gene · July 11, 2001 The gene CLPT1 (Colletotrichum lindemuthianum Protein Transport 1) encoding a Rab/GTPase was isolated from the filamentous fungus Colletotrichum lindemuthianum, the causal agent of bean anthracnose. At the amino acid level, CLPT1 shows between 54 and 80% i ... Full text Link to item Cite

Cerebral blood flow velocity response to magnesium sulfate in patients after subarachnoid hemorrhage.

Journal Article J Neurosurg Anesthesiol · July 2001 Featured Publication Magnesium sulfate therapy, standard in preventing seizures in preeclampsia, is under active investigation as a neuroprotective agent. The authors studied the effect of magnesium as a cerebral vasodilator by measuring the cerebral blood flow velocity (CBFV) ... Full text Link to item Cite

Initial amplification of duck hepatitis B virus covalently closed circular DNA after in vitro infection of embryonic duck hepatocytes is increased by cell cycle progression.

Journal Article Hepatology · July 2001 The relationship between the cell cycle and early amplification of duck hepatitis B virus covalently closed circular (CCC) DNA was studied after in vitro infection of fetal hepatocytes. We first showed that embryonic hepatocytes proliferated for at least 6 ... Full text Link to item Cite

Chemotherapy response of breast cancer depends on HER-2 status and anthracycline dose intensity in the neoadjuvant setting.

Journal Article Clin Cancer Res · June 2001 We evaluated the predictive value of a tumor's HER-2 status for chemotherapy response in the neoadjuvant setting and the effect of anthracycline dose intensity on this predictive value. HER-2 status was evaluated by immunochemistry on microbiopsy before ne ... Link to item Cite

Breast cancer occurred after treatment for Hodgkin's disease: analysis of 133 cases.

Journal Article Radiother Oncol · June 2001 PURPOSE: To assess the clinical and histological characteristics of breast cancer (BC) occurring after Hodgkin's disease (HD) and give possible therapies and prevention methods. MATERIALS AND METHODS: In a retrospective multicentric analysis, 117 women and ... Full text Link to item Cite

Systematic esophageal endoscopy screening in patients previously treated for head and neck squamous-cell carcinoma.

Journal Article Ann Oncol · May 2001 BACKGROUND: An attempt was made to improve metachronous oesophageal cancer prognosis through bi-annual systematic esophageal endoscopy screening in patients treated for head and neck cancer. PATIENTS AND METHODS: Bi-annual esophageal endoscopy, without a s ... Full text Link to item Cite

Carcinoma of an unknown primary site: a chemotherapy strategy based on histological differentiation--results of a prospective study.

Journal Article Ann Oncol · April 2001 BACKGROUND: To evaluate the efficacy and toxicity of a chemotherapy strategy based on histological differentiation, for patients with carcinoma of unknown primary site. PATIENTS AND METHODS: Forty-eight patients were prospectively included in the trial. Th ... Full text Link to item Cite

N. plumbaginifolia zeaxanthin epoxidase transgenic lines have unaltered baseline ABA accumulations in roots and xylem sap, but contrasting sensitivities of ABA accumulation to water deficit.

Journal Article J Exp Bot · March 2001 A series of transgenic lines of Nicotiana plumbaginifolia with modified expression of zeaxanthin epoxidase gene (ZEP) provided contrasting ABA accumulation in roots and xylem sap. For mild water stress, concentration of ABA in the xylem sap ([ABA](xylem)) ... Full text Link to item Cite

Quiet time: a nursing intervention to promote sleep in neurocritical care units.

Journal Article Am J Crit Care · March 2001 BACKGROUND: Patients in intensive care units are often sleep deprived, yet little research exists on the impact of nursing care on promoting sleep. OBJECTIVES: To determine if implementing a "quiet time" protocol to reduce external environmental stimuli is ... Link to item Cite

Intravenous magnesium sulfate does not increase ventricular CSF ionized magnesium concentration of patients with intracranial hypertension.

Journal Article Clin Neuropharmacol · 2001 Magnesium sulfate has attracted interest as a potential neuroprotectant but passage of magnesium ion into the central nervous system has not been well documented. For this study, we quantified plasma and cerebrospinal fluid (CSF) ionized magnesium concentr ... Full text Link to item Cite

Neurologic Intensive Care Unit Catastrophes: Airway, Breathing, and Circulation.

Journal Article Curr Treat Options Neurol · November 2000 When a catastrophic change in a patient occurs during the treatment of an underlying neurologic illness, management must be initiated to prevent secondary organ injury as disease specific treatment begins. Patients should be intubated, ventilated, and perf ... Full text Link to item Cite

A randomized, double-blinded comparison of ondansetron, droperidol, and placebo for prevention of postoperative nausea and vomiting after supratentorial craniotomy.

Journal Article Anesth Analg · August 2000 Featured Publication UNLABELLED: Nausea or vomiting occurs frequently after craniotomy. Because of the need for frequent postoperative neurological assessment, an effective antiemetic with minimal sedative side effects is needed. Therefore, we compared ondansetron to droperido ... Full text Link to item Cite

HIV-1 Nef protein binds to the cellular protein PACS-1 to downregulate class I major histocompatibility complexes.

Journal Article Nat Cell Biol · March 2000 Major-histocompatibility-complex (MHC) proteins are used to display, on the surface of a cell, peptides derived from foreign material - such as a virus - that is infecting that cell. Cytotoxic T lymphocytes then recognize and kill the infected cell. The HI ... Full text Link to item Cite

Neuroendocrine small cell carcinoma of the uterine cervix: what disease? What treatment? Report of ten cases and a review of the literature.

Journal Article Clin Oncol (R Coll Radiol) · 2000 Neuroendocrine small cell carcinoma of the uterine cervix (NESCCC) is an entity with very aggressive behaviour. The optimal initial therapeutic approach to this rare disease has not yet been clearly defined. We reviewed our experience of this disease over ... Full text Link to item Cite

Reliability of physical performance tests in four different randomized clinical trials.

Journal Article Arch Phys Med Rehabil · May 1999 OBJECTIVES: (1) To assess the test-retest reliability of physical performance tests in subject groups with different levels of impairment and disability, and (2) to assess the stability of these tests over different time intervals. DESIGN: Test-retest, rep ... Full text Link to item Cite

Survival and outcome after endotracheal intubation for acute stroke.

Journal Article Neurology · April 22, 1999 Featured Publication OBJECTIVE: To assess survival and functional outcome in patients endotracheally intubated after ischemic stroke (IS) or spontaneous intracerebral hemorrhage (ICH). BACKGROUND: Endotracheal intubation is both a necessary life support intervention and a meas ... Full text Link to item Cite

Enhanced duck hepatitis B virus gene expression following aflatoxin B1 exposure.

Journal Article Hepatology · April 1999 Epidemiological studies have suggested synergistic interactions between chronic hepatitis B virus (HBV) infection and aflatoxin B1 (AFB1) exposure in the etiology of hepatocellular carcinoma (HCC), although the molecular mechanisms of their interactions ar ... Full text Link to item Cite

Residues critical for duck hepatitis B virus neutralization are involved in host cell interaction.

Journal Article J Virol · April 1999 To date, no detailed analysis of the neutralization properties of duck hepatitis B virus (DHBV) has been reported, and it is not clear whether any of the known neutralization epitopes correspond to the viral receptor binding site or to sequences involved i ... Full text Link to item Cite

The SATE pronucleotide approach applied to acyclovir: part II. Effects of bis(SATE)phosphotriester derivatives of acyclovir on duck hepatitis B virus replication in vitro and in vivo.

Journal Article Antiviral Res · January 1999 The in vitro and in vivo antiviral activities of two mononucleoside phosphotriester derivatives of acyclovir (ACV) incorporating S-acyl-2-thioethyl (SATE) groups are reported using the duck model of hepatitis B (DHBV). In primary duck hepatocyte cultures, ... Full text Link to item Cite

Expression studies of the zeaxanthin epoxidase gene in nicotiana plumbaginifolia.

Journal Article Plant Physiol · November 1998 Abscisic acid (ABA) is a plant hormone involved in the control of a wide range of physiological processes, including adaptation to environmental stress and seed development. In higher plants ABA is a breakdown product of xanthophyll carotenoids (C40) via t ... Full text Link to item Cite

[Pain in reports. A fragmented mosaic].

Journal Article Krankenpfl Soins Infirm · October 1998 Link to item Cite

Phase II trial of oxaliplatin as first-line chemotherapy in metastatic colorectal cancer patients. Digestive Group of French Federation of Cancer Centers.

Journal Article J Clin Oncol · August 1998 PURPOSE: To evaluate the objective tumor response rate and safety profile of oxaliplatin when administered to patients with previously untreated metastatic colorectal adenocarcinoma. PATIENTS AND METHODS: A total of 39 patients were entered onto this phase ... Full text Link to item Cite

Phosphorylation of DHBV pre-S: identification of the major site of phosphorylation and effects of mutations on the virus life cycle.

Journal Article Virology · March 1, 1998 Four potential serine/threonine phosphorylation sites [(S/T)-P motif], designated P1-P4, on the pre-S protein of duck hepatitis B virus (DHBV) have been mutated. Mutants include single (P2, P3, P4) and double amino acid substitutions (P1 + P2, P3 + P4) and ... Full text Link to item Cite

Inhibitory effect of 2'-fluoro-5-methyl-beta-L-arabinofuranosyl-uracil on duck hepatitis B virus replication.

Journal Article Antimicrob Agents Chemother · February 1998 The antiviral activity of 2'-fluoro-5-methyl-beta-L-arabinofuranosyluracil (L-FMAU), a novel L-nucleoside analog of thymidine known to be an inhibitor of hepatitis B virus (HBV) replication in hepatoma cells (2.2.1.5 cell line), was evaluated in the duck H ... Full text Link to item Cite

Effect of hypobaria on ventilatory and CO2 responses to short-term hypoxic exposure in cats.

Journal Article Respir Physiol · January 1998 Featured Publication The effect of hypobaria on the ventilatory response to short-term hypoxia was studied by comparing the respiratory mechanical and inspired CO2 ventilatory responses to hypobaric hypoxia (438 mmHg) with normobaric hypoxia (11.8% FIO2). Fifteen spontaneously ... Full text Link to item Cite

Design, synthesis and structure relationships of new N,N',N",N"'-tetrakis (omega-amino alkyl) tetraazamacrocycles.

Journal Article Antivir Chem Chemother · January 1998 A number of N,N',N",N"'-tetrakis (omega-aminoalkyl) tetraazamacrocycles and related compounds were synthesized and evaluated for their inhibitory effects on human immunodeficiency virus type 1 (HIV-1) and duck hepatitis B virus (DHBV) replication. The acti ... Link to item Cite

Breast cancer in patients treated for Hodgkin's disease: clinical and pathological analysis of 76 cases in 63 patients.

Journal Article Eur J Cancer · December 1997 In a retrospective multicentric analysis, 63 women treated between 1941 to 1988 for Hodgkin's disease (HD) subsequently developed 76 breast cancers (BC). The median age at diagnosis of HD was 26 years (range 7-67), and 22 women (35%) were 20 years old or l ... Full text Link to item Cite

Selective inhibition of the duck hepatitis B virus by a new class of tetraazamacrocycles.

Journal Article Antimicrob Agents Chemother · November 1997 The antiviral activity of a new class of N,N,N',N",NA'''-pentakis (omega-aminoalkyl) tetraazamacrocycles was evaluated in primary duck hepatocyte cultures infected with the duck hepatitis B virus (DHBV). Three of the four tested compounds were able to sele ... Full text Link to item Cite

Postoperative nausea and vomiting. A retrospective analysis in patients undergoing elective craniotomy.

Journal Article J Neurosurg Anesthesiol · October 1997 Nausea and vomiting are important complications after craniotomy, for which there are little published epidemiologic data. We retrospectively examined the incidence of postcraniotomy nausea and vomiting to define risk factors. Medical records from 199 adul ... Link to item Cite

Higher doses of alpha-interferon do not increase the activity of the weekly cisplatin-interferon combination in advanced malignant mesothelioma.

Journal Article Eur J Cancer · October 1997 Management of advanced malignant mesothelioma (MM) still requires innovative systemic therapy as its prognosis is poorly affected by currently available chemotherapy. The combination cisplatin and alpha-interferon (alpha-INF) has synergistic antitumoral ac ... Full text Link to item Cite

A phase II study of cisplatin, 5-fluorouracil, leucovorin, and etoposide in advanced non-small-cell lung cancer.

Journal Article Am J Clin Oncol · April 1997 The aim of this study was to define the efficacy of a combination of cisplatin, 5-fluorouracil (5-FU), leucovorin, and etoposide (VP-16) in locally advanced or metastatic non-small-cell lung cancer (NSCLC). From September 1991 to November 1994, 28 patients ... Full text Link to item Cite

Comparison of remifentanil and fentanyl in patients undergoing craniotomy for supratentorial space-occupying lesions.

Journal Article Anesthesiology · March 1997 BACKGROUND: Remifentanil hydrochloride is an ultra-short-acting, esterase-metabolized mu-opioid receptor agonist. This study compared the use of remifentanil or fentanyl during elective supratentorial craniotomy for space-occupying lesions. METHODS: Sixty- ... Full text Link to item Cite

[Bilateral breast cancer after Hodgkin disease. Clinical and pathological characteristics and therapeutic possibilities: an analysis of 13 cases].

Journal Article Cancer Radiother · 1997 PURPOSE: Though Hodgkin's disease (HD) is one of the malignancies in which considerable progress has been made, long-term side effects have been observed, second primary cancer being the most significant. Several recent reports have indicated an increased ... Full text Link to item Cite

Perioperative management of aneurysmal subarachnoid hemorrhage

Journal Article Problems in Anesthesia · January 1, 1997 Cite

Endogenous interleukin 6 levels in patients with metastatic malignant melanoma: correlation with tumor burden.

Journal Article Clin Cancer Res · August 1996 The involvement of interleukin (IL-) 6 in malignant disease has been investigated in a variety of different malignancies. To evaluate whether serum IL-6 is a useful disease marker in metastatic malignant melanoma (MMM), we studied the time course of endoge ... Link to item Cite

n-Butyrate, a cell cycle blocker, inhibits early amplification of duck hepatitis B virus covalently closed circular DNA after in vitro infection of duck hepatocytes.

Journal Article J Virol · May 1996 During chronic hepadnavirus infection, virus persistence depends on the regulation of the pool of covalently closed circular DNA (cccDNA), which is the template for transcription of viral RNA species. The development of in vitro infection of duck hepatocyt ... Full text Link to item Cite

Intensive concomitant chemoradiotherapy in locally advanced unresectable squamous cell carcinoma of the head and neck: a phase II study of radiotherapy with cisplatin and 7-week continuous infusional fluorouracil.

Journal Article J Clin Oncol · April 1996 PURPOSE: To evaluate an intensive concomitant chemoradiotherapy protocol of conventional radiotherapy with intermittent cisplatin (CDDP) and continuous-infusion fluorouracil (5-FU) in unresectable, locally advanced squamous cell carcinoma of the head and n ... Full text Link to item Cite

Complete remission seven years after treatment for metastatic malignant melanoma.

Journal Article Cancer · March 1, 1996 BACKGROUND: In this study, the authors identified seven-year survivors after completion of the French multicenter Phase II trial of fotemustine for the treatment of metastatic malignant melanoma. METHODS: One hundred sixty-nine patients with metastatic mal ... Link to item Cite

2',3'-dideoxy-beta-L-5-fluorocytidine inhibits duck hepatitis B virus reverse transcription and suppresses viral DNA synthesis in hepatocytes, both in vitro and in vivo.

Journal Article Antimicrob Agents Chemother · February 1996 beta-L-Nucleoside analogs represent a new class of potent antiviral agents with low cytotoxicity which provide new hope in the therapy of chronic hepatitis B virus (HBV) infections. We evaluated the anti-HBV activity of 2',3'-dideoxy-beta-L-5-fluorocytidin ... Full text Link to item Cite

Fotemustine, dacarbazine, vindesine combination chemotherapy in advanced malignant melanoma: a phase II study of 43 patients.

Journal Article Melanoma Res · December 1995 Fotemustine and dacarbazine constitute the most active single chemotherapeutic agents in the treatment of melanoma. In this phase II study we evaluated the activity and toxicity of a combination of fotemustine, dacarbazine and vindesine as a means of incre ... Full text Link to item Cite

A phase II study of tamoxifen combined with cisplatin-interleukin 2 and alpha-interferon in metastatic melanoma.

Journal Article Am J Clin Oncol · October 1995 Tamoxifen (TAM) has been reported to enhance cisplatin (CDDP) cytotoxicity in experimental and clinical melanoma studies. Based on our previous experience with sequential cisplatin-interleukin-2 (IL2)-interferon (IFN), we performed a phase II study of TAM ... Full text Link to item Cite

Ventilatory management in critical neurologic illness.

Journal Article Neurol Clin · August 1995 Evolution and refinement of airway and ventilatory management has taken place in neurologic critical care. Applications for ventilatory management have been extended to virtually all acute life-threatening illnesses found in neurologic critical care units ... Link to item Cite

[Role of radiotherapy in the treatment of meningioma].

Journal Article Bull Cancer Radiother · 1995 Between 1962 and 1986, 32 patients with intracranial meningiomas were referred to the Institut Gustave-Roussy for external radiotherapy either after incomplete surgery, or unfavorable histology (meningiosarcoma/anaplastic meningioma), or after recurrences. ... Link to item Cite

Respiratory dysfunction in Guillain-Barré syndrome.

Journal Article Clin Chest Med · December 1994 Guillain-Barré syndrome (GBS) is the most common cause of acute paralysis and neuromuscular ventilatory failure. Although treatment with plasma exchange and immune globulins has decreased the duration of mechanical ventilation by half, 10% to 30% of patien ... Link to item Cite

Central nervous system modulation of respiratory function in the critically ill.

Journal Article New Horiz · November 1994 Neural control of ventilation is exercised at multiple levels and includes an array of sensors and diverse control areas. Abnormalities in the neural control of ventilation are seen in a variety of pathologic states and illnesses commonly seen in critical ... Link to item Cite

Follow up of soluble IL-2 receptor level in metastatic malignant melanoma patients treated by chemoimmunotherapy.

Journal Article Clin Exp Immunol · February 1994 Immunological parameters following chemoimmunotherapy combination were studied in 31 patients with metastatic malignant melanoma. They received Cisplatin (100 mg/m2) on day 1 and 28, recombinant IL-2 (rIL-2; Eurocetus) in continuous infusion from day 3 to ... Full text Link to item Cite

Incidence and perioperative management of tension pneumocephalus following craniofacial resection.

Journal Article J Neurosurg Anesthesiol · January 1994 This study is a retrospective review to evaluate factors associated with the risk of pneumocephalus following craniofacial resection and the management of tension pneumocephalus. Twenty-two craniofacial operative procedures were reviewed in 18 patients ent ... Full text Link to item Cite

Ventilatory drive and carbon dioxide response in ventilatory failure due to myasthenia gravis and Guillain-Barré syndrome.

Journal Article Crit Care Med · November 1993 OBJECTIVE: To test the hypothesis that either decreased ventilatory drive or decreased CO2 responsiveness accounts for the hypoventilation observed in patients during acute ventilatory failure from myasthenia gravis or Guillain-Barré syndrome. DESIGN: Pros ... Full text Link to item Cite

Sequential chemoimmunotherapy with cisplatin, interleukin-2, and interferon alfa-2a for metastatic melanoma.

Journal Article J Clin Oncol · November 1993 PURPOSE: To evaluate the activity and the toxicity of the combination of cisplatin (CDDP)/recombinant interleukin-2 (rIL-2) and interferon alfa-2a (IFN alpha) in disseminated malignant melanoma (DMM). PATIENTS AND METHODS: Between December 1990 and March 1 ... Full text Link to item Cite

Dicranin, an antimicrobial and 15-lipoxygenase inhibitor from the moss Dicranum scoparium.

Journal Article J Nat Prod · July 1993 Extracts of nine mosses, collected in Switzerland, were screened for antimicrobial, antioxidative, and 15-lipoxygenase (15-lpo) inhibitory activities. The CH2Cl2 extract of Dicranum scoparium was found to possess pronounced antimicrobial activity against B ... Full text Link to item Cite

Effect of selective diaphragmatic paralysis on the inspiratory motor drive.

Journal Article J Appl Physiol (1985) · May 1993 Using alpha-chloralose-anesthetized mechanically ventilated vagotomized dogs, we assessed the effects of selective diaphragmatic paralysis on the inspiratory motor drive. Diaphragmatic paralysis was accomplished by a bolus injection of vecuronium, a neurom ... Full text Link to item Cite

Relapse in Guillain-Barré syndrome after treatment with human immune globulin.

Journal Article Neurology · May 1993 Seven adult patients received human immune globulin intravenously as initial therapy for Guillain-Barré syndrome. Although all patients initially stabilized or improved, five patients deteriorated 1 to 16 days after completion of treatment. In all five pat ... Full text Link to item Cite

Alterations in natural anticoagulant levels during allogeneic bone marrow transplantation: a prospective study in 27 patients.

Journal Article Bone Marrow Transplant · April 1993 The natural anticoagulants (antithrombin III, protein C, protein S), plasminogen and tissue plasminogen activator antigen (t-PA ag), were measured in 27 consecutive patients following allogeneic BMT. Thrombosis and veno-occlusive disease were not seen in t ... Link to item Cite

Intensive management and treatment of severe Guillain-Barré syndrome.

Journal Article Crit Care Med · March 1993 OBJECTIVE: To review the management and therapeutic approaches to severe acute Guillain-Barré syndrome, with emphasis on the ventilatory dysfunction, and cardiovascular instability seen in patients with this syndrome. DATA SOURCES/STUDY SELECTION: Clinical ... Full text Link to item Cite

Chemoimmunotherapy of metastatic malignant melanoma. The Salpétrière Hospital (SOMPS) experience.

Journal Article Eur J Cancer · 1993 Optimistic results were obtained in the treatment of 39 patients with surgically incurable metastatic malignant melanoma using a regimen including 2 to 3 monthly induction cycles of cis-diamminedichloroplatinum (CDDP), recombinant interleukin-2 (rIL-2) and ... Full text Link to item Cite

[Primary chemotherapy in the treatment of breast cancer].

Journal Article Ann Chir Plast Esthet · December 1992 Between 1980 and 1992, 457 consecutive patients with initial breast cancer entered two successive protocols combining neoadjuvant chemotherapy, hormonotherapy (tamoxifen) and locoregional radiotherapy (teleradiotherapy and boost by iridium) as exclusive lo ... Link to item Cite

[Treatment of primary cancer of the breast in elderly women. Role of hormone therapy].

Journal Article Presse Med · October 17, 1992 About 40 percent of newly diagnosed breast cancers occur in women older than 65. Hormonotherapy plays an important role as adjuvant treatment of primary cancers in post-menopausal women because of their great hormone-dependence. The drug of choice is tamox ... Link to item Cite

Effects of 9, 12, 15-octadecatrien-6-ynoic acid on the metabolism of arachidonic acid in platelets and on platelet aggregation.

Journal Article Thromb Res · March 15, 1992 An acetylenic fatty acid: 9,12,15-octadecatrien-6-ynoic acid (dicranin) was extracted from Dicranum Scoparium and preincubated with platelets which were then stimulated by exogenous arachidonic acid (20:4 n-6). This molecule at 10(-4) M weakly inhibited th ... Full text Link to item Cite

Amyloid myopathy presenting with respiratory failure.

Journal Article J Neurol Neurosurg Psychiatry · February 1992 Amyloidosis is a rare cause of myopathy. Its prominent or presenting feature may be respiratory failure. Physiological measurement of transdiaphragmatic pressure and biopsy specimens of muscle show the pathological mechanism to be diaphragm weakness due to ... Full text Link to item Cite

Hypermetabolism and hypercatabolism in Guillain-Barré syndrome.

Journal Article JPEN J Parenter Enteral Nutr · 1992 We studied 21 patients with Guillain-Barré syndrome who demonstrated multiple nutritional risk factors upon admission to an intensive care unit: ventilator dependence (71.4%), adynamic ileus (23.8%), significant weight loss in the 2 weeks before admission ... Full text Link to item Cite

Phase I study of Datelliptium chloride, hydrochloride given by 24-h continuous intravenous infusion.

Journal Article Cancer Chemother Pharmacol · 1992 Datelliptium chloride, hydrochloride (SR 95 156B, NSC 626718X, DHE) was studied in a phase I trial of escalating doses given on a single 24-h continuous intravenous infusion schedule. Doses were escalated from 40 to 500 mg/m2 in 19 patients who received a ... Full text Link to item Cite

Effects of 9,12,15-octadecatrien-6-ynoic acid on the metabolism of arachidonic acid in platelets and on the platelet aggregation.

Journal Article Agents Actions Suppl · 1992 An acetylenic fatty acid: 9,12,15-octadecatrien-6-ynoic acid (dicranin), extracted from Dicranum Scoparium was preincubated with platelets stimulated by exogenous arachidonic acid (20:4 n-6). Dicranin (10(-4) M) weakly inhibited the cyclooxygenase activity ... Full text Link to item Cite

Preoperative lumbar epidural morphine improves postoperative analgesia and ventilatory function after transsternal thymectomy in patients with myasthenia gravis.

Journal Article Crit Care Med · December 1991 OBJECTIVE: To test the hypothesis that preoperative lumbar epidural morphine improves postoperative pain control and ventilatory function after transsternal thymectomy in patients with myasthenia gravis. DESIGN: The study design was randomized, placebo-con ... Full text Link to item Cite

Fotemustine (S 10036) in the intra-arterial treatment of liver metastasis from malignant melanoma. A phase II Study.

Journal Article Am J Clin Oncol · October 1991 Fotemustine is a new nitrosourea which has shown some efficacy on disseminated malignant melanoma (DMM) (24.2% response rate (RR) among 153 patients in a Phase II trial) but little activity on hepatic metastasis (8.8% RR). In order to improve those poor re ... Full text Link to item Cite

Diaphragmatic performance during recovery from acute ventilatory failure in Guillain-Barré syndrome and myasthenia gravis.

Journal Article Chest · February 1991 Diaphragmatic muscle performance during acute ventilatory failure due to Guillain-Barré syndrome and myasthenia gravis was assessed to evaluate (1) diaphragmatic function during weaning from ventilatory support and (2) diaphragmatic tension-time integral ( ... Full text Link to item Cite

[Tumor regression as a prognostic factor in breast cancer].

Journal Article Bull Cancer · 1991 Two hundred and fifty evaluable patients with breast cancer entered a protocol combining neoadjuvant and consolidation therapy by vinblastine (V), thiotepa (T), methotrexate (m) and 5-fluorouracil (f) (VTMF) with or without Adriamycin (A) (Doxorubicin; Adr ... Link to item Cite

Cerebrospinal fluid atrial natriuretic factor in intracranial disease.

Journal Article Stroke · November 1990 We tested the hypothesis that the concentration of atrial natriuretic factor in the cerebrospinal fluid is an indicator of brain injury in patients with intracranial disease. Atrial natriuretic factor concentration was measured in 72 samples of cerebrospin ... Full text Link to item Cite

[Malignant melanoma: hepatic intra-arterial chemotherapy].

Journal Article Pathol Biol (Paris) · October 1990 Link to item Cite

[The role of neo-adjuvant chemotherapy in breast cancers].

Journal Article Pathol Biol (Paris) · October 1990 Link to item Cite

Intensive management of severe head injury.

Journal Article Chest · July 1990 Intensive management of patients with severe head injury offers the best hope of minimizing death and functional disability in a young, working population. Secondary neurologic insult can be decreased by cardiorespiratory support and ICP control from the o ... Full text Link to item Cite

Results of neoadjuvant chemotherapy and radiation therapy in the breast-conserving treatment of 250 patients with all stages of infiltrative breast cancer.

Journal Article Cancer · July 1, 1990 Two hundred fifty evaluable patients with breast cancer entered a protocol combining neoadjuvant and consolidation therapy by vinblastine (V), thiotepa (T), methotrexate (M), and 5-fluorouracil (F) (VTMF), with or without Adriamycin (A) (doxorubicin; Adria ... Full text Link to item Cite

Acute management of intracranial hemorrhage in patients receiving thrombolytic therapy: case reports.

Journal Article Neurosurgery · May 1990 Intracranial hemorrhage is an uncommon complication of antithrombotic therapy. We present two patients who suffered life-threatening intracranial bleeding as a complication of thrombolytic/anticoagulant treatment. Early diagnosis and treatment appear to be ... Full text Link to item Cite

[Expectations and defeat in the treatment of epithelial cancer of the ovary].

Journal Article Ann Med Interne (Paris) · 1990 One hundred and thirty-nine patients were treated between 1980 and 1988 for epithelial cancer of the ovary: 35 stage I, 30 stage II, 66 stage III and 8 stage IV (according to the IFGO classification). For stage I and II patients, who underwent total abdomi ... Link to item Cite

Cerebral aneurysms: mechanisms of injury and critical care interventions.

Journal Article Crit Care Clin · October 1989 Subarachnoid hemorrhage remains an important cause of mortality and morbidity despite recent attempts at aggressive surgical and medical therapy. This article reviews proposed mechanisms of brain injury following subarachnoid hemorrhage and rationale for t ... Link to item Cite

Sodium and water regulation in a patient with cerebral salt wasting.

Journal Article Arch Neurol · August 1989 Hyponatremia, in patients with central nervous system disease, can be attributable to impaired free water excretion (syndrome of inappropriate secretion of antidiuretic hormone) or to excessive sodium excretion (cerebral salt wasting). We present a patient ... Full text Link to item Cite

Brain resuscitation. Medical management and innovations.

Journal Article Crit Care Nurs Clin North Am · March 1989 In this article, we have reviewed the pathophysiology and several therapeutic strategies for cerebral ischemia. It seems likely that there will never be simple therapeutic answers to the complex pathophysiology of cerebral ischemia as we now understand it. ... Link to item Cite

Treatment of sagittal sinus thrombosis associated with cerebral hemorrhage and intracranial hypertension.

Journal Article Stroke · July 1988 Two cases of complete sagittal sinus occlusion with multiple brain hemorrhages, elevated intracranial pressure, and disseminated intravascular coagulation are described. These patients were successfully managed using pentobarbital-induced coma to ameliorat ... Full text Link to item Cite

Cardiovascular autonomic dysfunction in Guillain-Barré syndrome. Therapeutic implications of Swan-Ganz monitoring.

Journal Article Arch Neurol · January 1988 Guillain-Barré syndrome (GBS) is an acute inflammatory polyneuropathy that may lead to quadriparesis, ventilatory failure, and autonomic dysfunction. While significant mortality due to ventilatory failure has been associated with this syndrome, this compli ... Full text Link to item Cite

Cerebral blood flow autoregulation during intracranial hypertension in hypoxic lambs.

Journal Article Am J Physiol · December 1987 We tested the hypothesis that hypoxic hypoxia interferes with cerebral blood flow (CBF) autoregulation when intracranial pressure (ICP) is elevated in pentobarbital-anesthetized lambs (3 to 9 days old). Cerebral perfusion pressure (CPP) was lowered stepwis ... Full text Link to item Cite

Cerebral blood flow autoregulation during intracranial hypertension in hypoxic lambs

Journal Article American Journal of Physiology - Heart and Circulatory Physiology · 1987 We tested the hypothesis that hypoxic hypoxia interferes with cerebral blood flow (CBF) autoregulation when intracranial pressure (ICP) is elevated in pentobarbital-anesthetized lambs (3 to 9 days old). Cerebral perfusion pressure (CPP) was lowered stepwis ... Cite

Laboratory and field trials at Ifakara (Kilombero District, Tanzania) on the plant molluscicide Swartzia madagascariensis.

Journal Article Acta Trop · March 1986 The molluscicidal activity of crushed seed pods of Swartzia madagascariensis was assessed by laboratory and field trials. Mature dry seed pods were ground and extracted in tap water for 24 h. Water extracts exerted a significant molluscicidal activity agai ... Link to item Cite

Evoked potentials in neurointensive care medicine

Journal Article American Journal of EEG Technology · January 1, 1986 Severe, acute disorders of the central nervous system account for a large proportion of patients seen in neurointensive care units (NICUs). In such cases of actual or threatened brain damage, it is necessary, for diagnostic, therapeutic, and prognostic pur ... Full text Cite

Neurologic intensive care unit monitoring.

Journal Article Crit Care Clin · July 1985 Monitoring modalities unique to the neurologic intensive care unit include intracranial pressure monitors and neuroelectrophysiologic monitors. Each modality fullfills criteria for accuracy, responsivity during clinical change, and stability over time for ... Link to item Cite

Dopamine and dobutamine in septic shock. A comparison.

Journal Article Arch Int Physiol Biochim · November 1984 Full text Link to item Cite

Dopamine and dobutamine in septic shock. A comparison

Journal Article Anesthesiology · January 1, 1981 Cite

Nosocomial influenza A (H1N1) infection.

Journal Article Am J Med Technol · May 1980 In late February 1979, 21 days after admission to the hospital for a diagnostic evaluation of weight loss and abdominal pain, a 25-year-old female developed nosocomial influenza. The case was presumed to be associated with an outbreak of influenza involvin ... Link to item Cite