Scholars@Duke
Chen-Hao Yeh

Chen-Hao Yeh

Assistant Professor in Medicine
Medicine, Duke Human Vaccine Institute
chen.hao.yeh@duke.edu
PO Box 103020, Durham, NC 27710
2 Genome Court, Room 3011, Durham, NC 27710

Selected Publications

Recall of B cell memory depends on relative locations of prime and boost immunization.

Journal Article Science immunology · May 2022 Immunization or microbial infection can establish long-term B cell memory not only systemically but also locally. Evidence has suggested that local B cell memory contributes to early local plasmacytic responses after secondary challenge. However, it is unc ... Full text Cite

Primary germinal center-resident T follicular helper cells are a physiologically distinct subset of CXCR5hiPD-1hi T follicular helper cells.

Journal Article Immunity · February 8, 2022 T follicular helper (Tfh) cells are defined by a Bcl6+CXCR5hiPD-1hi phenotype, but only a minor fraction of these reside in germinal centers (GCs). Here, we examined whether GC-resident and -nonresident Tfh cells share a common physiology and function. Flu ... Full text Link to item Cite

Immune checkpoint modulation enhances HIV-1 antibody induction.

Journal Article Nat Commun · February 19, 2020 Eliciting protective titers of HIV-1 broadly neutralizing antibodies (bnAbs) is a goal of HIV-1 vaccine development, but current vaccine strategies have yet to induce bnAbs in humans. Many bnAbs isolated from HIV-1-infected individuals are encoded by immun ... Full text Open Access Link to item Cite

Germinal center responses to complex antigens.

Journal Article Immunol Rev · July 2018 Germinal centers (GCs) are the primary sites of antibody affinity maturation, sites where B-cell antigen-receptor (BCR) genes rapidly acquire mutations and are selected for increasing affinity for antigen. This process of hypermutation and affinity-driven ... Full text Link to item Cite

Germinal center entry not selection of B cells is controlled by peptide-MHCII complex density.

Journal Article Nat Commun · March 2, 2018 B cells expressing high affinity antigen receptors are advantaged in germinal centers (GC), perhaps by increased acquisition of antigen for presentation to follicular helper T cells and improved T-cell help. In this model for affinity-dependent selection, ... Full text Open Access Link to item Cite

Cutting Edge: c-Maf Is Required for Regulatory T Cells To Adopt RORγt+ and Follicular Phenotypes.

Journal Article J Immunol · December 15, 2017 Regulatory T cells (Tregs) adopt specialized phenotypes defined by coexpression of lineage-defining transcription factors, such as RORγt, Bcl-6, or PPARγ, alongside Foxp3. These Treg subsets have unique tissue distributions and diverse roles in maintaining ... Full text Link to item Cite

Efficient Culture of Human Naive and Memory B Cells for Use as APCs.

Journal Article J Immunol · November 15, 2016 The ability to culture and expand B cells in vitro has become a useful tool for studying human immunity. A limitation of current methods for human B cell culture is the capacity to support mature B cell proliferation. We developed a culture method to suppo ... Full text Link to item Cite

Dietary flavonoid naringenin induces regulatory T cells via an aryl hydrocarbon receptor mediated pathway.

Journal Article J Agric Food Chem · March 7, 2012 The aryl hydrocarbon receptor (AhR), a transcription factor mediating xenobiotic detoxification, plays a considerable role in regulatory T cell (Treg) induction. Tregs regulate the immune system, thus suppressing allergies and autoimmune diseases. This stu ... Full text Link to item Cite

Polysaccharides PS-G and protein LZ-8 from Reishi (Ganoderma lucidum) exhibit diverse functions in regulating murine macrophages and T lymphocytes.

Journal Article J Agric Food Chem · August 11, 2010 Bioactive components in Ganoderma lucidum mainly include polysaccharides (PS-G) and immunomodulatory protein Ling Zhi-8 (LZ-8). These components may have diverse regulatory functions in the immune system. However, the PS-G preparations from different proce ... Full text Link to item Cite

Oral administration of an Enoki mushroom protein FVE activates innate and adaptive immunity and induces anti-tumor activity against murine hepatocellular carcinoma.

Journal Article Int Immunopharmacol · February 2010 FVE is a documented immunomodulatory protein purified from Enoki mushroom (Flammulina velutipes) and known as an activator for human T lymphocytes. This present study was aimed to investigate the anti-tumor effect and the related mechanisms of oral adminis ... Full text Link to item Cite

Immunological impact of magnetic nanoparticles (Ferucarbotran) on murine peritoneal macrophages

Journal Article Journal of Nanoparticle Research · January 1, 2010 Ferucarbotran, a clinically used superparamagnetic iron oxide, is widely developed as a magnetic resonance imaging (MRI) contrast agent and has the potential to improve the monitoring of macrophage recirculation in vivo. However, the biological effect of F ... Full text Cite

A novel immunomodulatory protein from Poria cocos induces Toll-like receptor 4-dependent activation within mouse peritoneal macrophages.

Journal Article J Agric Food Chem · July 22, 2009 Poria cocos is an important Oriental medical fungus with multiple functionalities, yet its bioactive substances and the mechanisms involved have not been fully characterized. A novel immunomodulatory protein (P. cocos immunomodulatory protein; PCP) was pur ... Full text Link to item Cite