Scholars@Duke
David W Jang

David W Jang

Associate Professor of Head and Neck Surgery & Communication Sciences
Rhinology and Skull Base Surgery
david.jang@duke.edu
Duke South Yellow Zone 4000, DUMC Box 3805, Durham, NC 27710
40 Medicine Circle, DUMC Box 3805, Durham, NC 27710

Selected Publications

Turbinate Injection of Botulinum Toxin in the Treatment of the Chronic Rhinitis.

Journal Article Laryngoscope · May 2025 OBJECTIVES: This systemic review with meta-analysis evaluated the effect of intranasal BTX-A turbinate injection on chronic rhinitis-related symptoms. DATA SOURCES: PubMed, SCOPUS, Embase, Web of Science, and Cochrane databases. REVIEW METHODS: We reviewed ... Full text Link to item Cite

Utility of Existing Patient-Reported Outcome Measures for Identifying Non-Rhinogenic Facial Pain.

Journal Article Laryngoscope · March 22, 2025 OBJECTIVE: Facial pain/pressure is often non-rhinogenic and migraine-related in etiology. However, this is frequently misdiagnosed as sinusitis, leading to inappropriate antibiotic utilization and unnecessary procedures. We assessed the utility of the 3-It ... Full text Link to item Cite

Dose-Related Effects and Bleeding Risk of Ketorolac in Pediatric Tonsillectomy.

Journal Article Otolaryngol Head Neck Surg · March 2025 OBJECTIVE: To investigate the safety and effectiveness of dose-related ketorolac administration in children who underwent tonsillectomy. DATA SOURCES: Data sourced from PubMed, SCOPUS, Embase, Web of Science, and Cochrane databases, encompassing literature ... Full text Link to item Cite

Enhancing Endothelial Differentiation of Mesenchymal Stem Cells Derived from Human Turbinates Using Lab-on-a-Chip Technology

Journal Article Medicina (Lithuania) · March 1, 2025 Background and Objectives: Endothelial cells are essential to various therapeutic strategies for cardiovascular diseases. Developing efficient methods to generate large quantities of well-defined endothelial cells could improve cardiovascular treatment. Th ... Full text Cite

Recent developments in olfactory neuroblastoma research.

Journal Article Curr Opin Otolaryngol Head Neck Surg · February 1, 2025 PURPOSE OF REVIEW: Olfactory neuroblastoma (ONB) is a rare malignancy originating from olfactory neuroepithelial cells. Given its uncommon nature and complex clinical presentation, this comprehensive review highlights recent findings and treatment approach ... Full text Link to item Cite

Impact of Intra-Phenotypic Nasal Vestibular Variation on Local Airflow Dynamics.

Journal Article Laryngoscope · January 2025 OBJECTIVES: Many individuals with healthy normal nasal anatomy and function exhibit a prominent notch indentation at the junction of the ala and sidewall, specifically around the anterior-superior region of the unilateral nasal vestibule up to the internal ... Full text Link to item Cite

Concurrent Nasal Symptoms in Non-Rhinogenic Headache.

Journal Article OTO Open · 2025 OBJECTIVE: This study aims to characterize concurrent nasal symptoms in a cohort of patients with non-rhinogenic headache (NRH) presenting to an otolaryngology clinic. STUDY DESIGN: A prospective cohort. SETTING: Single tertiary care institution. METHODS: ... Full text Link to item Cite

Baseline disease characteristics by surgery history among patients with chronic rhinosinusitis with nasal polyps (CRSwNP) in the global AROMA registry.

Journal Article Am J Otolaryngol · 2025 PURPOSE: The global Assessing long-teRm Outcomes in dupiluMAb (AROMA) registry study aims to characterize the long-term, real-world use of dupilumab in patients with chronic rhinosinusitis with nasal polyps (CRSwNP). This paper reports interim analysis of ... Full text Link to item Cite

Comparison of Patient-Reported Outcomes Between Dorsal Preservation and Conventional Dorsal Hump Reduction Rhinoplasty: A Systematic Review and Meta-Analysis

Journal Article Aesthetic Plastic Surgery · January 1, 2025 Background: Recently, improvements in dorsal preservation rhinoplasty have been reported to minimize swelling, reduce scarring, and the aesthetic lines of the nasal dorsum. Methods: Sourcing studies from six databases, the change in patient-reported scores ... Full text Cite

Sinonasal Complications of Combined Transseptal-Transnasal and Bilateral Transnasal Approaches for Endoscopic Endonasal Transsphenoidal Pituitary Surgery.

Journal Article World Neurosurg · December 2024 BACKGROUND: The endoscopic combined transseptal-transnasal technique for pituitary adenoma excision is notable for enhanced postoperative functional outcomes. Our study compared the incidence of anterior nasal septal perforation and the resulting sinonasal ... Full text Link to item Cite

The lateral based nasopharyngeal flap: A novel vascularized flap for skull base reconstruction.

Journal Article Head Neck · October 2024 As the indications for endoscopic skull base approaches have increased, so has the need for more versatile vascularized flaps for skull base reconstruction. Here, we describe a novel lateral based nasopharyngeal flap (LNPF). Two cadaver heads were dissecte ... Full text Link to item Cite

The Development of a Human Respiratory Mucosa-on-a-Chip Using Human Turbinate-Derived Mesenchymal Stem Cells.

Journal Article Medicina (Kaunas, Lithuania) · October 2024 Background and Objectives: This study aimed to investigate the influence of a respiratory mucosa-on-a-chip on the respiratory epithelial differentiation potential of human nasal inferior turbinate-derived stem cells (hNTSCs). Materials and Method ... Full text Cite

Development of a New Swine Model Resembling Human Empty Nose Syndrome.

Journal Article Medicina (Kaunas) · September 24, 2024 Background and Objectives: Empty nose syndrome (ENS) is a debilitating condition that often results from traumatic or iatrogenic causes, such as nasal surgery. There are various conservative and surgical treatments for ENS, but their effectiveness remains ... Full text Link to item Cite

Olfactory neuroblastoma mimics molecular heterogeneity and lineage trajectories of small-cell lung cancer.

Journal Article Cancer Cell · June 10, 2024 The olfactory epithelium undergoes neuronal regeneration from basal stem cells and is susceptible to olfactory neuroblastoma (ONB), a rare tumor of unclear origins. Employing alterations in Rb1/Trp53/Myc (RPM), we establish a genetically engineered mouse m ... Full text Link to item Cite

Predictors of Non-Rhinogenic Facial Pain or Pressure in Otolaryngology Clinic.

Journal Article Otolaryngol Head Neck Surg · May 2024 OBJECTIVES: Identify demographic and clinical characteristics that may help differentiate non-rhinogenic facial pain or pressure (NRFP) from sinusitis. STUDY DESIGN: Retrospective single-institution study. SETTING: Tertiary Care Center Rhinology Clinic. ME ... Full text Link to item Cite

Barosinusitis due to routine weather changes: A cross-sectional analysis of public websites.

Journal Article World J Otorhinolaryngol Head Neck Surg · March 2024 BACKGROUND: Sinusitis is a common diagnosis that can be erroneously associated with routine weather-related barometric pressure changes. In actuality, these pressure changes likely exacerbate migraine headaches, which can cause facial pain and pressure rat ... Full text Link to item Cite

Safety and Feasibility of Steroid-Eluting Stent as a Bolster in Endoscopic Anterior Skull Base Reconstruction.

Journal Article Ann Otol Rhinol Laryngol · January 2024 BACKGROUND: With a rising incidence of cerebrospinal fluid (CSF) leaks, endoscopic endonasal CSF leak repair is increasingly performed. Current approaches utilize a variety of materials including free mucosal grafts and vascularized flaps, but post-op leak ... Full text Link to item Cite

Olfactory neuroblastoma

Journal Article Mini-invasive Surgery · January 1, 2024 Originating from the olfactory neuroepithelium, olfactory neuroblastoma is a rare malignant tumor of the nasal cavity that typically affects adults between the ages of 35 and 70. Clinical presentation predominantly consists of nonspecific symptoms such as ... Full text Cite

SNOT-22 Quality of Life Scores Improve After Endoscopic Endonasal Repair of Spontaneous Cerebrospinal Fluid Rhinorrhea.

Journal Article Ann Otol Rhinol Laryngol · September 2023 OBJECTIVES: Patients with spontaneous cerebrospinal fluid (CSF) rhinorrhea can experience significant sinonasal symptom burden, leading to poor quality of life (QOL). The objective of this study was to investigate sinonasal outcome test-22 (SNOT-22) scores ... Full text Link to item Cite

Use of Tympanostomy T-Tube for Endoscopic Endonasal Marsupialization of Small Rathke's Cleft Cysts: A Case Series.

Journal Article J Neurol Surg B Skull Base · August 2023 Objectives  This article describes a novel technique implementing the use of a tympanostomy t-tube to provide long-term marsupialization of small Rathke's cleft cysts (RCCs). Design  A retrospective review of electronic medical records was performed to col ... Full text Link to item Cite

Nasopharyngeal Carcinoma: Case Presentation and Literature Review of Treatment Innovation with Immunotherapy.

Journal Article J Neurol Surg Rep · July 2023 Nasopharyngeal carcinoma (NPC), a rare head and neck malignancy, arises from the epithelial lining of nasopharyngeal mucosa. The confluence of various risk factors, such as latent Epstein-Barr virus infection, genetic susceptibility, smoking, alcohol consu ... Full text Link to item Cite

Nasopharyngeal Carcinoma: Case Presentation and Literature Review of Treatment Innovation with Immunotherapy

Journal Article Journal of Neurological Surgery Reports · July 2023 AbstractNasopharyngeal carcinoma (NPC), a rare head and neck malignancy, arises from the epithelial lining of nasopharyngeal mucosa. The confluence of various risk factors, such as latent Epstein–Barr virus infection, genet ... Full text Cite

Data from Deconstructing Olfactory Epithelium Developmental Pathways in Olfactory Neuroblastoma

Other · June 6, 2023 <div><p>Olfactory neuroblastoma is a rare tumor arising from the olfactory cleft region of the nasal cavity. Because of the low incidence of this tumor, as well as an absence of established cell lines and murine models, understanding th ... Full text Cite

Table S1 from Deconstructing Olfactory Epithelium Developmental Pathways in Olfactory Neuroblastoma

Other · June 6, 2023 <p>Tumor demographics separated by Hyams grade, Dulguerov T stage, and gene expression groups (low versus high) used for survival analysis in Figure 5 and Figure S4. Average Ki-67 mRNA expression obtained from bulk RNA-Seq outputs. Average Ki ... Full text Cite

FIGURE 2 from Deconstructing Olfactory Epithelium Developmental Pathways in Olfactory Neuroblastoma

Other · June 6, 2023 <p>Pseudodeconvolution of ONB bulk RNA-seq defines proportions of cell type–specific transcriptomics across low- and high-grade tumors. <b>A,</b> Stacked bar chart depicts predicted proportions of cell types in bulk tumors when ma ... Full text Cite

FIGURE 4 from Deconstructing Olfactory Epithelium Developmental Pathways in Olfactory Neuroblastoma

Other · June 6, 2023 <p>PRC2 complex expression in ONB. <b>A,</b> PRC2 transcripts in the core complex are mostly upregulated in high-grade ONB. <b>B,</b> EPOP expression is significantly increased in high-grade ONB compared with low grade ... Full text Cite

Figure S4 from Deconstructing Olfactory Epithelium Developmental Pathways in Olfactory Neuroblastoma

Other · June 6, 2023 <p>Additional Kaplan-Meier survival curves based on Hyams Grade, Dulguerov T-stage, and MKI67 gene expression. Log-rank test used to determine statistical significance.</p> ... Full text Cite

FIGURE 3 from Deconstructing Olfactory Epithelium Developmental Pathways in Olfactory Neuroblastoma

Other · June 6, 2023 <p>Patterns of gene expression in the normal differentiating OE. <b>A,</b> Trajectory UMAP depicting differentiation states across pseudotime, in seven normal olfactory mucosa biopsies scRNA-seq from Durante and colleagues, 2020 a ... Full text Cite

Figure S2 from Deconstructing Olfactory Epithelium Developmental Pathways in Olfactory Neuroblastoma

Other · June 6, 2023 <p>RNA expression signatures of ONB from Classe et al., 2018 based on markers traditionally associated with sinonasal undifferentiated carcinoma (A), small cell neuroendocrine carcinoma (B), and olfactory neuroblastoma (C), divided by control ... Full text Cite

FIGURE 1 from Deconstructing Olfactory Epithelium Developmental Pathways in Olfactory Neuroblastoma

Other · June 6, 2023 <p>Schematic of the deconvolution workflow. Diagram of normal OE in the top left colored by cell identity (HBC: yellow; GBC: pink; immature OSN: blue; mature OSN: orange; Sustentacular: green; Bowman's Gland: purple; Olfactory ensheating cell ... Full text Cite

Figure S3 from Deconstructing Olfactory Epithelium Developmental Pathways in Olfactory Neuroblastoma

Other · June 6, 2023 <p>Identical RNA expression plots to those shown in Fig. 4 A and B, but with IDH2 mutant ONB separated out from wild type tumors.</p> ... Full text Cite

Figure S4 from Deconstructing Olfactory Epithelium Developmental Pathways in Olfactory Neuroblastoma

Other · June 6, 2023 <p>Additional Kaplan-Meier survival curves based on Hyams Grade, Dulguerov T-stage, and MKI67 gene expression. Log-rank test used to determine statistical significance.</p> ... Full text Cite

FIGURE 3 from Deconstructing Olfactory Epithelium Developmental Pathways in Olfactory Neuroblastoma

Other · June 6, 2023 <p>Patterns of gene expression in the normal differentiating OE. <b>A,</b> Trajectory UMAP depicting differentiation states across pseudotime, in seven normal olfactory mucosa biopsies scRNA-seq from Durante and colleagues, 2020 a ... Full text Cite

Table S1 from Deconstructing Olfactory Epithelium Developmental Pathways in Olfactory Neuroblastoma

Other · June 6, 2023 <p>Tumor demographics separated by Hyams grade, Dulguerov T stage, and gene expression groups (low versus high) used for survival analysis in Figure 5 and Figure S4. Average Ki-67 mRNA expression obtained from bulk RNA-Seq outputs. Average Ki ... Full text Cite

FIGURE 1 from Deconstructing Olfactory Epithelium Developmental Pathways in Olfactory Neuroblastoma

Other · June 6, 2023 <p>Schematic of the deconvolution workflow. Diagram of normal OE in the top left colored by cell identity (HBC: yellow; GBC: pink; immature OSN: blue; mature OSN: orange; Sustentacular: green; Bowman's Gland: purple; Olfactory ensheating cell ... Full text Cite

Figure S2 from Deconstructing Olfactory Epithelium Developmental Pathways in Olfactory Neuroblastoma

Other · June 6, 2023 <p>RNA expression signatures of ONB from Classe et al., 2018 based on markers traditionally associated with sinonasal undifferentiated carcinoma (A), small cell neuroendocrine carcinoma (B), and olfactory neuroblastoma (C), divided by control ... Full text Cite

Data from Deconstructing Olfactory Epithelium Developmental Pathways in Olfactory Neuroblastoma

Other · June 6, 2023 <div><p>Olfactory neuroblastoma is a rare tumor arising from the olfactory cleft region of the nasal cavity. Because of the low incidence of this tumor, as well as an absence of established cell lines and murine models, understanding th ... Full text Cite

Figure S3 from Deconstructing Olfactory Epithelium Developmental Pathways in Olfactory Neuroblastoma

Other · June 6, 2023 <p>Identical RNA expression plots to those shown in Fig. 4 A and B, but with IDH2 mutant ONB separated out from wild type tumors.</p> ... Full text Cite

FIGURE 2 from Deconstructing Olfactory Epithelium Developmental Pathways in Olfactory Neuroblastoma

Other · June 6, 2023 <p>Pseudodeconvolution of ONB bulk RNA-seq defines proportions of cell type–specific transcriptomics across low- and high-grade tumors. <b>A,</b> Stacked bar chart depicts predicted proportions of cell types in bulk tumors when ma ... Full text Cite

Figure S1 from Deconstructing Olfactory Epithelium Developmental Pathways in Olfactory Neuroblastoma

Other · June 6, 2023 <p>A and B identical to Figure 2A and B, but with the two IDH2 mutant tumors separated out from the other tumors into their own category. C shows estimated respiratory cell type proportions across normal OE, low grade, high grade, and IDH2 mu ... Full text Cite

FIGURE 5 from Deconstructing Olfactory Epithelium Developmental Pathways in Olfactory Neuroblastoma

Other · June 6, 2023 <p>Glandular and olfactory ensheathing cell markers are present in low-grade ONB and are associated with increased survival. <b>A,</b> UMAP visualization of non-tumor olfactory mucosa scRNA-seq data depicts the cell type–specific ... Full text Cite

FIGURE 5 from Deconstructing Olfactory Epithelium Developmental Pathways in Olfactory Neuroblastoma

Other · June 6, 2023 <p>Glandular and olfactory ensheathing cell markers are present in low-grade ONB and are associated with increased survival. <b>A,</b> UMAP visualization of non-tumor olfactory mucosa scRNA-seq data depicts the cell type–specific ... Full text Cite

Figure S1 from Deconstructing Olfactory Epithelium Developmental Pathways in Olfactory Neuroblastoma

Other · June 6, 2023 <p>A and B identical to Figure 2A and B, but with the two IDH2 mutant tumors separated out from the other tumors into their own category. C shows estimated respiratory cell type proportions across normal OE, low grade, high grade, and IDH2 mu ... Full text Cite

FIGURE 4 from Deconstructing Olfactory Epithelium Developmental Pathways in Olfactory Neuroblastoma

Other · June 6, 2023 <p>PRC2 complex expression in ONB. <b>A,</b> PRC2 transcripts in the core complex are mostly upregulated in high-grade ONB. <b>B,</b> EPOP expression is significantly increased in high-grade ONB compared with low grade ... Full text Cite

Individual SNOT-22 Items Aid in Differentiating Between Spontaneous Cerebrospinal Fluid Rhinorrhea and Chronic Rhinosinusitis Without Nasal Polyps.

Journal Article Ann Otol Rhinol Laryngol · June 2023 OBJECTIVES: Spontaneous cerebrospinal fluid (CSF) rhinorrhea is a diagnostic challenge due to its overlapping symptomatology with other sinonasal diseases. The objective of this study was to investigate whether items on the sinonasal outcome test (SNOT)-22 ... Full text Link to item Cite

Deconstructing Olfactory Epithelium Developmental Pathways in Olfactory Neuroblastoma.

Journal Article Cancer Res Commun · June 2023 UNLABELLED: Olfactory neuroblastoma is a rare tumor arising from the olfactory cleft region of the nasal cavity. Because of the low incidence of this tumor, as well as an absence of established cell lines and murine models, understanding the mechanisms dri ... Full text Link to item Cite

Figure S3 from Deconstructing olfactory epithelium developmental pathways in olfactory neuroblastoma

Other · May 18, 2023 <p>Identical RNA expression plots to those shown in Fig. 4 A and B, but with IDH2 mutant ONB separated out from wild type tumors.</p> ... Full text Cite

Table S1 from Deconstructing olfactory epithelium developmental pathways in olfactory neuroblastoma

Other · May 18, 2023 <p>Tumor demographics separated by Hyams grade, Dulguerov T stage, and gene expression groups (low versus high) used for survival analysis in Figure 5 and Figure S4. Average Ki-67 mRNA expression obtained from bulk RNA-Seq outputs. Average Ki ... Full text Cite

Figure S1 from Deconstructing olfactory epithelium developmental pathways in olfactory neuroblastoma

Other · May 18, 2023 <p>A and B identical to Figure 2A and B, but with the two IDH2 mutant tumors separated out from the other tumors into their own category. C shows estimated respiratory cell type proportions across normal OE, low grade, high grade, and IDH2 mu ... Full text Cite

Figure S2 from Deconstructing olfactory epithelium developmental pathways in olfactory neuroblastoma

Other · May 18, 2023 <p>RNA expression signatures of ONB from Classe et al., 2018 based on markers traditionally associated with sinonasal undifferentiated carcinoma (A), small cell neuroendocrine carcinoma (B), and olfactory neuroblastoma (C), divided by control ... Full text Cite

Figure S3 from Deconstructing olfactory epithelium developmental pathways in olfactory neuroblastoma

Other · May 18, 2023 <p>Identical RNA expression plots to those shown in Fig. 4 A and B, but with IDH2 mutant ONB separated out from wild type tumors.</p> ... Full text Cite

Figure S4 from Deconstructing olfactory epithelium developmental pathways in olfactory neuroblastoma

Other · May 18, 2023 <p>Additional Kaplan-Meier survival curves based on Hyams Grade, Dulguerov T-stage, and MKI67 gene expression. Log-rank test used to determine statistical significance.</p> ... Full text Cite

Table S1 from Deconstructing olfactory epithelium developmental pathways in olfactory neuroblastoma

Other · May 18, 2023 <p>Tumor demographics separated by Hyams grade, Dulguerov T stage, and gene expression groups (low versus high) used for survival analysis in Figure 5 and Figure S4. Average Ki-67 mRNA expression obtained from bulk RNA-Seq outputs. Average Ki ... Full text Cite

Figure S1 from Deconstructing olfactory epithelium developmental pathways in olfactory neuroblastoma

Other · May 18, 2023 <p>A and B identical to Figure 2A and B, but with the two IDH2 mutant tumors separated out from the other tumors into their own category. C shows estimated respiratory cell type proportions across normal OE, low grade, high grade, and IDH2 mu ... Full text Cite

Data from Deconstructing olfactory epithelium developmental pathways in olfactory neuroblastoma

Other · May 18, 2023 <div>Abstract<p>Olfactory neuroblastoma is a rare tumor arising from the olfactory cleft region of the nasal cavity. Due to the low incidence of this tumor, as well as an absence of established cell lines and murine models, understandin ... Full text Cite

Figure S2 from Deconstructing olfactory epithelium developmental pathways in olfactory neuroblastoma

Other · May 18, 2023 <p>RNA expression signatures of ONB from Classe et al., 2018 based on markers traditionally associated with sinonasal undifferentiated carcinoma (A), small cell neuroendocrine carcinoma (B), and olfactory neuroblastoma (C), divided by control ... Full text Cite

Figure S4 from Deconstructing olfactory epithelium developmental pathways in olfactory neuroblastoma

Other · May 18, 2023 <p>Additional Kaplan-Meier survival curves based on Hyams Grade, Dulguerov T-stage, and MKI67 gene expression. Log-rank test used to determine statistical significance.</p> ... Full text Cite

Immunoglobulin Deficiency and the Unified Airway.

Journal Article Otolaryngol Clin North Am · February 2023 Primary Ig deficiencies are a heterogeneous group of disorders with widespread implications for the unified airway. Manifestations can vary greatly, with some patients being asymptomatic, whereas others suffering from acute and chronic life-threatening pat ... Full text Link to item Cite

The Unified Airway: From Concept to Practice.

Journal Article Otolaryngol Clin North Am · February 2023 Full text Link to item Cite

Intraoperative Ex Vivo Pituitary Adenoma Subtype Classification Using Noncontact Laser Fluorescence Spectroscopy

Conference 32nd Annual Meeting North American Skull Base Society · February 2023 Full text Cite

Nasal Cavity Squamous Cell Carcinoma: Factors Associated With Treatment Outcomes and Potential Organ Preservation.

Journal Article Am J Rhinol Allergy · January 2023 BACKGROUND: Squamous cell carcinoma of the nasal cavity (NCSCC) is a rare, challenging malignancy. Surgical resection of this tumor can cause significant facial deformity, and indications for adjuvant or organ preservation therapies are not well-described. ... Full text Link to item Cite

Characterizing Olfactory Dysfunction in Patients with Unilateral Cleft Lip Nasal Deformities.

Journal Article Facial Plast Surg Aesthet Med · 2023 Background: Unilateral cleft lip nasal deformity (uCLND) is associated with olfactory dysfunction, but the underlying etiology remains poorly understood. Objective: To investigate the etiology of uCLND-associated olfactory dysfunction using clinical, compu ... Full text Open Access Link to item Cite

Preparation of Human Olfactory Epithelial Biopsies for Downstream Analysis.

Journal Article Methods Mol Biol · 2023 The olfactory mucosa, lining a portion of the nasal cavity, houses the primary olfactory sensory neurons responsible for odor transduction, along with supporting cell populations. Tremendous advances have come from studying the peripheral olfactory system ... Full text Link to item Cite

Retrospective Review of Surgical Site Infections after Endoscopic Endonasal Sellar and Parasellar Surgery: Multicenter Quality Data from the North American Skull Base Society.

Journal Article J Neurol Surg B Skull Base · December 2022 Introduction  Transnasal access to the anterior skull base provides a minimally invasive approach for sellar and parasellar masses compared with its open counterparts. The unique microbiome of the sinonasal mucosa provides distinct challenges not encounter ... Full text Link to item Cite

Persistent post-COVID-19 smell loss is associated with immune cell infiltration and altered gene expression in olfactory epithelium.

Journal Article Science translational medicine · December 2022 SARS-CoV-2 causes profound changes in the sense of smell, including total smell loss. Although these alterations are often transient, many patients with COVID-19 exhibit olfactory dysfunction that lasts months to years. Although animal and human autopsy st ... Full text Cite

Endoscopic Sinus Surgery in Older Patients With Significant Medical Comorbidities.

Journal Article Am J Rhinol Allergy · September 2022 BACKGROUND: Endoscopic sinus surgery (ESS) offers excellent outcomes for patients with chronic rhinosinusitis (CRS) in the general population. It is unclear whether older patients with significant medical comorbidities experience similar benefits. OBJECTIV ... Full text Link to item Cite

Rapid tissue prototyping with micro-organospheres.

Journal Article Stem cell reports · September 2022 In vitro tissue models hold great promise for modeling diseases and drug responses. Here, we used emulsion microfluidics to form micro-organospheres (MOSs), which are droplet-encapsulated miniature three-dimensional (3D) tissue models that can be establish ... Full text Open Access Cite

Endoscopic Sinus Surgery for Cystic Fibrosis: Variables Influencing Sinonasal and Pulmonary Outcomes.

Journal Article Am J Rhinol Allergy · May 2022 BACKGROUND: Endoscopic sinus surgery is a well-established treatment for chronic rhinosinusitis in patients with cystic fibrosis, though its benefits seem to be limited to improving sinonasal symptoms rather than affecting lung function. OBJECTIVE: This st ... Full text Link to item Cite

Management of Chronic Rhinosinusitis Prior to Otolaryngology Referral: An Opportunity for Quality Improvement.

Journal Article Otolaryngol Head Neck Surg · March 2022 OBJECTIVE: The management of chronic rhinosinusitis (CRS) by a nonotolaryngologist prior to otolaryngology referral is an important component of the patient care pathway. The purpose of this study is to characterize CRS management during this period and to ... Full text Link to item Cite

Aging-related olfactory loss is associated with olfactory stem cell transcriptional alterations in humans.

Journal Article J Clin Invest · February 15, 2022 BACKGROUNDPresbyosmia, or aging-related olfactory loss, occurs in a majority of humans over age 65 years, yet remains poorly understood, with no specific treatment options. The olfactory epithelium (OE) is the peripheral organ for olfaction and is subject ... Full text Link to item Cite

Sinus headache: changing the treatment paradigm.

Journal Article Curr Opin Otolaryngol Head Neck Surg · February 1, 2022 PURPOSE OF REVIEW: Although the majority of patients with sinus headache do not have rhinosinusitis, many patients will unnecessarily undergo work-up and treatment for rhinosinusitis. This leads to a significant cost burden to the healthcare system. In the ... Full text Link to item Cite

Postoperative changes in cognition and cerebrospinal fluid neurodegenerative disease biomarkers.

Journal Article Ann Clin Transl Neurol · February 2022 OBJECTIVE: Numerous investigators have theorized that postoperative changes in Alzheimer's disease neuropathology may underlie postoperative neurocognitive disorders. Thus, we determined the relationship between postoperative changes in cognition and cereb ... Full text Open Access Link to item Cite

Geographic Variations in Healthcare Utilization and Expenditure for Chronic Rhinosinusitis: A Population-Based Approach.

Journal Article Laryngoscope · December 2021 OBJECTIVES/HYPOTHESIS: Chronic rhinosinusitis (CRS) is a common and costly health problem in the United States. A better understanding of healthcare resource utilization (HCRU) and healthcare expenditure (HCE) pertaining to CRS is required. The objective o ... Full text Link to item Cite

Sinus Irrigation Penetration After Proposed Modified Draf IIa Technique in a Side-to-Side Cadaveric Model.

Journal Article Am J Rhinol Allergy · July 2021 BACKGROUND: Endoscopic sinus surgery (ESS) is an effective intervention for patients with medically refractory chronic rhinosinusitis. Frontal sinusotomy is the most challenging part of ESS, with one of the key outcomes being access for topical irrigations ... Full text Link to item Cite

Healthcare Resource Utilization for Chronic Rhinosinusitis in Older Adults.

Journal Article Healthcare (Basel) · June 25, 2021 OBJECTIVES: Chronic rhinosinusitis (CRS) is a common and costly health problem in the United States. While often associated with younger adults, CRS can affect the elderly. As the aging population increases in the United States, the cost burden of CRS in o ... Full text Open Access Link to item Cite

Assessment of Available Online Information About Nasopharyngeal Swab Testing in Patient Instructions for Sinus and Pituitary Surgery.

Journal Article JAMA Otolaryngol Head Neck Surg · June 1, 2021 This cross-sectional study assess online preoperative and postoperative patient information regarding the potential risks of severe acute respiratory syndrome coronavirus 2 nasopharyngeal swab testing for those with a history of sinus or skull-base surgery ... Full text Link to item Cite

General Complications after Endoscopic Sinus Surgery in Smokers: A 2005-2016 NSQIP Analysis.

Journal Article Ann Otol Rhinol Laryngol · April 2021 BACKGROUND: Exposure to cigarette smoke has been associated with a higher incidence of postoperative complications across a variety of surgical specialties. However, it is unclear if smoking increases this risk after endoscopic sinus surgery (ESS). Because ... Full text Link to item Cite

Survival Outcomes in Sinonasal Poorly Differentiated Squamous Cell Carcinoma.

Journal Article Laryngoscope · April 2021 OBJECTIVE: Sinonasal squamous cell carcinoma (SCC) is rare with no consensus on treatment regimen. Our goal is to analyze treatment outcomes in poorly differentiated SCC (PDSCC) using a large national database. STUDY DESIGN: Retrospective database study. M ... Full text Link to item Cite

Survival outcomes in sinonasal carcinoma with neuroendocrine differentiation: A NCDB analysis.

Journal Article Am J Otolaryngol · 2021 BACKGROUND: Sinonasal carcinoma with neuroendocrine differentiation (SCND) is a rare group of tumors with poor prognosis. Treatment and sequence of therapies are still unclear. The goal of this study is to analyze treatment outcomes in SCND using a nationa ... Full text Link to item Cite

Olfactory-Specific Quality of Life Outcomes after Endoscopic Endonasal Surgery of the Sella.

Journal Article Allergy Rhinol (Providence) · 2021 OBJECTIVE: To assess olfactory outcomes as measured by an olfactory-specific quality of life (QOL) questionnaire in patients undergoing EESBS for sellar lesions. DESIGN: Retrospective case series. SETTING: Tertiary academic medical center. PARTICIPANTS: In ... Full text Link to item Cite

Sinonasal Squamous Cell Carcinoma Outcomes: Does Treatment at a High-Volume Center Confer Survival Benefit?

Journal Article Otolaryngol Head Neck Surg · November 2020 OBJECTIVE: To determine whether treatment of sinonasal squamous cell carcinoma (SCC) at a high-volume facility affects survival. STUDY DESIGN: Retrospective database analysis. SETTING: National Cancer Database (2004-2014). SUBJECTS AND METHODS: The Nationa ... Full text Link to item Cite

The use of balloon dilation in revision sinus surgery.

Journal Article Int Forum Allergy Rhinol · October 2020 BACKGROUND: Recent studies have demonstrated a dramatic increase in the use of balloon sinus dilation (BSD) in the United States. However, the use of BSD specifically in revision sinus surgery has not been investigated. This study addresses the question of ... Full text Link to item Cite

The MARBLE Study Protocol: Modulating ApoE Signaling to Reduce Brain Inflammation, DeLirium, and PostopErative Cognitive Dysfunction.

Journal Article J Alzheimers Dis · 2020 BACKGROUND: Perioperative neurocognitive disorders (PND) are common complications in older adults associated with increased 1-year mortality and long-term cognitive decline. One risk factor for worsened long-term postoperative cognitive trajectory is the A ... Full text Open Access Link to item Cite

Novel Application of Steroid Eluting Stent in Petrous Apex Cholesterol Granuloma.

Journal Article J Neurol Surg B Skull Base · October 2019 Objective  This study describes the safety and efficacy of mometasone furoate eluting stents in the management of petrous apex cholesterol granuloma approached through an endonasal endoscopic route and assesses the restenosis rate. Methods  Consecutive pat ... Full text Link to item Cite

Symptom Profile of Chronic Rhinosinusitis Versus Obstructive Sleep Apnea in a Tertiary Rhinology Clinic.

Journal Article Ann Otol Rhinol Laryngol · October 2019 OBJECTIVES: Patients with undiagnosed obstructive sleep apnea (OSA) often present to an otolaryngologist with symptoms of chronic rhinosinusitis (CRS). This study analyzes symptom profiles of such patients to help identify those who may benefit from polyso ... Full text Link to item Cite

Factors associated with opioid use after endoscopic sinus surgery.

Journal Article Laryngoscope · August 2019 OBJECTIVES/HYPOTHESIS: Responsible prescribing of postoperative pain medications is necessary in combatting the current opioid epidemic in the United States. The goal of this study was to determine which clinical factors affect opioid usage following funct ... Full text Link to item Cite

Sinonasal Quality of Life Outcomes After Extended Endonasal Approaches to the Skull Base.

Journal Article J Neurol Surg B Skull Base · August 2019 Introduction  Endoscopic endonasal skull base surgery (EESBS) leads to significant alterations in sinonasal anatomy and physiology. However, there is limited data available on quality of life (QOL) outcomes following EESBS. Methods  A retrospective review ... Full text Link to item Cite

Factors Associated with Revision Surgery after Balloon Sinuplasty.

Journal Article Otolaryngol Head Neck Surg · April 2019 OBJECTIVE: Although balloon sinuplasty (BSP) is increasing in popularity, little is known about which patients are the ideal candidates. The objective of this study is to investigate factors that may be associated with BSP failure. STUDY DESIGN: Retrospect ... Full text Link to item Cite

Role of induction chemotherapy in sinonasal malignancies: a systematic review.

Journal Article Int Forum Allergy Rhinol · February 2019 BACKGROUND: Cancers of the paranasal sinuses are rare tumors that tend to be aggressive and usually are diagnosed at an advanced stage. Despite being rare, these tumors include a wide spectrum of histological subtypes with different biological behaviors. C ... Full text Link to item Cite

International assessment of inter- and intrarater reliability of the International Frontal Sinus Anatomy Classification system.

Journal Article Int Forum Allergy Rhinol · January 2019 BACKGROUND: Inconsistencies in the nomenclature of structures of the frontal sinus have impeded the development of a validated "reference standard" classification system that surgeons can reliably agree upon. The International Frontal Sinus Anatomy Classif ... Full text Link to item Cite

Balloon Catheter Dilation of the Sinuses: A 2011-2014 MarketScan Analysis.

Journal Article Otolaryngol Head Neck Surg · December 2018 OBJECTIVE: This study uses a large national claims-based database to analyze recent practice patterns related to balloon catheter dilation (BCD) of the sinuses. STUDY DESIGN: Retrospective study. SETTING: Academic. SUBJECTS AND METHODS: Patients with chron ... Full text Link to item Cite

Management of epistaxis in patients with ventricular assist device: a retrospective review.

Journal Article J Otolaryngol Head Neck Surg · August 2, 2018 BACKGROUND: Patients with a ventricular assist device (VAD) are at risk for epistaxis due to the need for anticoagulation. Additionally, these patients develop acquired von Willebrand syndrome (AvWS) due to these devices. Management is complicated by the r ... Full text Link to item Cite

Transnasal Transsphenoidal Elevation of Optic Chiasm in Secondary Empty Sella Syndrome Following Prolactinoma Treatment.

Journal Article World Neurosurg · April 2018 BACKGROUND: Prolactinomas are typically treated nonsurgically with a dopamine agonist. Once the tumor shrinks, adjacent eloquent structures, such as the optic apparatus, can become skeletonized and herniate into the dilated parasellar space. CASE DESCRIPTI ... Full text Link to item Cite

Correlation between sinus and lung cultures in lung transplant patients with cystic fibrosis.

Journal Article Int Forum Allergy Rhinol · March 2018 BACKGROUND: Lung transplantation has revolutionized the treatment of end-stage pulmonary disease due to cystic fibrosis. However, infection of the transplanted lungs can lead to serious complications, including graft failure and death. Although many of the ... Full text Link to item Cite

Endoscopic Endonasal Approaches to the Orbit.

Journal Article Int Ophthalmol Clin · 2018 Full text Link to item Cite

Radiodensity of the Ostiomeatal Complex in Recurrent Acute Rhinosinusitis.

Journal Article Otolaryngol Head Neck Surg · November 2017 Objective Recurrent acute rhinosinusitis (RARS) can be an elusive diagnosis due to the lack of clinical and radiographic findings in between acute episodes. This study aims to identify objective computed tomography (CT) characteristics in RARS. Study Desig ... Full text Link to item Cite

Adverse Events in Endoscopic Sinus Surgery for Infectious Orbital Complications of Sinusitis: 30-Day NSQIP Pediatric Outcomes.

Journal Article Otolaryngol Head Neck Surg · October 2017 Objective Identify predictors of adverse events for children who underwent endoscopic sinus surgery for treatment of orbital complications associated with sinusitis. Study Design Cross-sectional analysis of a US national database. Setting American College ... Full text Link to item Cite

Sinusitis in patients on tumor necrosis factor alpha inhibitors.

Journal Article Int Forum Allergy Rhinol · April 2017 BACKGROUND: Tumor necrosis factor alpha (TNF-α) inhibitors have revolutionized treatment of many inflammatory diseases. Sinusitis after initiation of TNF-α inhibitors has been observed, but has not been well described in the literature. We aim to character ... Full text Link to item Cite

Radiographic characterization of the retroantral ethmoid cell.

Journal Article Int Forum Allergy Rhinol · December 2016 BACKGROUND: The retroantral ethmoid cell (RAEC) is defined as a posterior ethmoid cell that pneumatizes inferolaterally behind the posterior wall of the maxillary sinus. The RAEC can present a challenge to otolaryngologists during endoscopic ethmoidectomy ... Full text Link to item Cite

Why sinonasal disease spares the inferior turbinate: An immunohistochemical analysis.

Conference Laryngoscope · May 2016 OBJECTIVES/HYPOTHESIS: Clinically, inflammatory polyps are found in the middle turbinate (MT) in patients with chronic rhinosinusitis (CRS) but not in the inferior turbinate (IT). The purpose of this study was to investigate differences in protein expressi ... Full text Link to item Cite

Surgical Correction of an Extensive Skull Base Defect as a Result of Pneumocele.

Journal Article J Craniofac Surg · January 2016 Pneumocele is a condition involving the pathologic expansion of paranasal sinuses with corresponding bony erosion of the skull base. Extensive pneumocele can lead to pneumocephalus, especially in patients with long-term cerebrospinal fluid shunts. Here, th ... Full text Link to item Cite

Product comparison model in otolaryngology: Equivalency analysis of absorbable hemostatic agents after endoscopic sinus surgery.

Thesis Dissertation · January 2016 OBJECTIVES/HYPOTHESIS: Evidence-based medicine in otolaryngology literature continues to be lacking, especially with regard to new products brought to market. The marketing of products often includes statements of benefit that have limited objective suppor ... Link to item Cite

Characterizing airflow profile in the postoperative maxillary sinus by using computational fluid dynamics modeling: A pilot study.

Journal Article Am J Rhinol Allergy · 2016 BACKGROUND: Maxillary antrostomy is commonly performed during endoscopic sinus surgery. Little is known about the association surrounding recalcitrant maxillary sinusitis, antrostomy size, and intranasal airflow changes. Furthermore, the interaction betwee ... Full text Link to item Cite

Primary endoscopic surgery

Chapter · January 1, 2016 Primary endoscopic surgery of the frontal sinus is a technically challenging procedure that requires a thorough understanding of the three-dimensional anatomy of the frontal recess. In addition to recognizing the various types of frontal recess cells as de ... Full text Cite

Comorbidities in patients with all-positive symptoms on sinonasal outcomes test quality-of-life instrument.

Journal Article Laryngoscope · December 2015 OBJECTIVES/HYPOTHESIS: The Sinonasal Outcomes Test-20 (SNOT-20) is a validated tool to assess treatment outcomes in patients with chronic rhinosinusitis (CRS). In the clinic, we observed that patients who responded with a positive score on all 20 items of ... Full text Link to item Cite

Nasopharyngeal Masses Arising from Embryologic Remnants of the Clivus: A Case Series.

Journal Article J Neurol Surg Rep · November 2015 Objectives This study aims to (1) discuss rare nasopharyngeal masses originating from embryologic remnants of the clivus, and (2) discuss the embryology of the clivus and understand its importance in the diagnosis and treatment of these masses. Design and ... Full text Open Access Link to item Cite

Direct Repair of Iatrogenic Internal Carotid Artery Injury During Endoscopic Endonasal Approach Surgery With Temporary Endovascular Balloon-Assisted Occlusion: Technical Case Report.

Journal Article Neurosurgery · September 2015 BACKGROUND AND IMPORTANCE: Iatrogenic internal carotid artery (ICA) injuries during endoscopic endonasal approach (EEA) surgeries are associated with a high morbidity and mortality, with few acceptable methods described for repair. CLINICAL PRESENTATION: A ... Full text Link to item Cite

Bony erosion patterns in patients with allergic fungal sinusitis.

Journal Article American journal of rhinology & allergy · July 2015 ObjectiveTo investigate bony erosion patterns in allergic fungal sinusitis (AFS) and to determine whether the extent of erosion correlates with demographics and preoperative clinical parameters.Study designRetrospective review of prospect ... Full text Cite

Pathophysiology and etiologic factors of chronic rhinosinusitis

Chapter · April 1, 2015 Our current understanding of chronic rhinosinusitis (CRS) is that its etiology is multifactorial. One example of a distinct disease process leading to CRS is aspirin sensitivity, in which a dysregulation of eicasanoid metabolism leads to upper and lower ai ... Cite

Modeling alterations in sinonasal physiology after skull base surgery.

Journal Article Am J Rhinol Allergy · 2015 BACKGROUND: Endonasal endoscopic skull base surgery (EESBS) often requires significant alterations in intranasal anatomy. For example, posterior septectomy (PS) with middle turbinate resection (MTR) is frequently performed to provide access to large sellar ... Full text Link to item Cite

The effect of smoking on quality of life following sinus surgery: 10-year follow-up.

Journal Article ORL J Otorhinolaryngol Relat Spec · 2015 OBJECTIVES: The purpose of this study is to investigate the 10-year postoperative quality of life outcomes in smokers and nonsmokers with chronic rhinosinusitis. STUDY DESIGN: This is a single-institution prospective cohort study. METHODS: 235 patients who ... Full text Link to item Cite

Supraorbital ethmoid cell: a consistent landmark for endoscopic identification of the anterior ethmoidal artery.

Journal Article Otolaryngol Head Neck Surg · December 2014 OBJECTIVE: To demonstrate that the supraorbital ethmoid cell (SOEC) is a consistent and reliable landmark in identification of the anterior ethmoidal artery (AEA). STUDY DESIGN: Retrospective radiographic study. SETTING: Tertiary care rhinology practice. S ... Full text Link to item Cite

Thyroglossal duct cyst carcinoma: case report and review of the literature.

Journal Article Ear Nose Throat J · September 2013 Well-differentiated thyroid carcinoma of a thyroglossal duct cyst (TGDC) is a rare entity, found in about 1% of all TGDCs. Diagnosis is usually made incidentally after a Sistrunk procedure. Options for further therapy include total thyroidectomy, T4 suppre ... Link to item Cite

Adult sleep apnea and related procedures

Chapter · September 1, 2013 Obstructive sleep apnea (OSA) is the most prevalent breathing disorder in sleep, affecting up to 20 % of the population, with approximately 5 % experiencing excessive daytime sleepiness [1, 2]. The total economic burden of OSA including health-care costs, ... Full text Cite

Budesonide nasal irrigations in the postoperative management of chronic rhinosinusitis.

Journal Article International forum of allergy & rhinology · September 2013 BackgroundNasal steroids play an important role in the postoperative management of patients with chronic rhinosinusitis (CRS). However, commercially available nasal steroid sprays may not deliver adequate amounts of medication to the entire postop ... Full text Cite

Palliative surgery for head and neck cancer with extensive skin involvement.

Journal Article Laryngoscope · May 2013 OBJECTIVES/HYPOTHESIS: To evaluate the role of regional and free tissue transfer for the palliative management of head and neck cancer with extensive skin involvement. STUDY DESIGN: Case Series. METHODS: A retrospective review was performed of patients tre ... Full text Link to item Cite

Epidemiologic factors and surgical outcomes in patients with nasal polyposis and asthma.

Journal Article ORL J Otorhinolaryngol Relat Spec · 2013 BACKGROUND/AIM: To evaluate the role of epidemiologic factors in surgical outcomes for patients with nasal polyposis (NP) and asthma. METHODS: Data was prospectively collected on patients who underwent endoscopic sinus surgery over a 7-year period. Among p ... Full text Link to item Cite

Syphilitic lymphadenitis diagnosed via fine needle aspiration biopsy.

Journal Article Diagnostic cytopathology · August 2011 Syphilis is coming back in the recent a few decades especially in the gay and HIV populations. Since syphilis can be "the great mimic" clinically and pathologically, a case report with updated review can be helpful to the medical community. We report, a ca ... Full text Cite

Tympanostomy tube outcomes in children at-risk and not at-risk for developmental delays.

Journal Article Int J Pediatr Otorhinolaryngol · February 2011 OBJECTIVES: To assess outcomes after tympanostomy tubes in children at-risk or not-at-risk for developmental delays based on criteria from the American Academies of Pediatrics, Family Physicians, and Otolaryngology - Head and Neck Surgeons. METHODS: Histor ... Full text Link to item Cite

Case report of Madelung's disease with upper airway obstruction

Conference Laryngoscope · January 1, 2011 Educational Objective: At the conclusion of this presentation, the participants should be able to discuss the presentation and management of Madelung's disease, including the rare case of upper airway obstruction. Objectives: We present the case of a patie ... Full text Cite

Hamartoma of the larynx: A report of two cases

Conference Laryngoscope · January 1, 2011 Educational Objective: At the conclusion of this presentation, the participants should be able to describe the clinical presentation, histopathologic findings, and management strategies of hamartomas occurring in the larynx. Objectives: Hamartomas of the l ... Full text Cite

Autophagy and tumor cell dormancy in head and neck cancer

Conference Laryngoscope · January 1, 2011 Educational Objective: At the conclusion of this presentation, the participants should be able to discuss the concepts of autophagy and tumor cell dormancy, and how these cellular processes may be targeted in order to prolong survival in patients with squa ... Full text Cite

Neuromonics™ Tinnitus Treatment: preliminary experience in a private practice setting.

Conference Laryngoscope · 2010 EDUCATIONAL OBJECTIVE: At the conclusion of this presentation, the participants should be able to identify the principles behind the Neuromonics™ Tinnitus Treatment (NTT) and understand its strengths and potential shortfalls. OBJECTIVES: To describe the pr ... Full text Link to item Cite

Hearing loss in vogt-koyanagi-harada syndrome treated with intratympanic steroids

Conference Laryngoscope · August 17, 2009 Educational Objective:At the conclusion of this presentation, the participants should be able todescribe Vogt-Koyanagi-Harada (VHK) Syndrome, know it as a rarecause of inner ear symptoms, and recognize the possible utility ofintratympanic steroid injection ... Full text Cite

Case report of patient with neck mass diagnosed as syphilitic lymphadenitis via fine needle aspiration biopsy

Conference Laryngoscope · January 1, 2009 Objectives: To describe a rare case of syphilitic lymphadenitis diagnosed via fine needle aspiration biopsy (FNAB). To review the pitfalls associated with the diagnosis of syphilitic lymphadenitis. Methods: The patient's medical records were reviewed. The ... Full text Cite

Transoral robotic surgery using a carbon dioxide flexible laser for tumors of the upper aerodigestive tract.

Journal Article Laryngoscope · December 2008 OBJECTIVE: To determine the safety, feasibility, and efficacy of coupling transoral robotic technology with the flexible carbon dioxide (CO2) laser for various tumors of the oropharynx and supraglottic larynx. STUDY DESIGN: Prospective, pilot trial. METHOD ... Full text Link to item Cite