Scholars@Duke
Deborah T. Gold

Deborah T. Gold

Professor Emeritus in Psychiatry and Behavioral Sciences
Psychiatry, Child & Family Mental Health & Community Psychiatry
deborah.gold@duke.edu
Box 3003 Med Ctr, Durham, NC 27710
1507 Busse Bldg, Durham, NC 27710

Selected Publications

Treatment patterns in women with postmenopausal osteoporosis using abaloparatide: a real-world observational study.

Journal Article Osteoporos Int · August 2024 UNLABELLED: Review of medical records from 173 women with osteoporosis who received abaloparatide treatment revealed that 96.0% had at least one visit for osteoporosis management and 55.5% had medication support group access. The most common reasons for di ... Full text Link to item Cite

A Qualitative Study to Assess US Patient Preferences between new Transdermal System and Injectable Anabolic Therapies for Osteoporosis Treatment.

Journal Article Arch Osteoporos · April 4, 2022 UNLABELLED: US patients with osteoporosis included in three focus groups identified efficacy, safety, cost, and convenience as important attributes of treatment when choosing between anabolic therapies with high stated preference for the solid Microstructu ... Full text Link to item Cite

Keepers of the House: A documentary.

Journal Article Clin Teach · February 2022 BACKGROUND: Our documentary, Keepers of the House, highlights ways that hospital housekeepers, typically unnoticed care team members, provide emotional support for patients and their families. This film addresses a gap in education by emphasizing the impor ... Full text Open Access Link to item Cite

Abaloparatide Real-World Patient Experience Study.

Journal Article JBMR Plus · March 2021 Despite the availability of various osteoporosis treatments, adherence remains suboptimal. One contributing factor may be patient experience with therapy. This US, multicenter, combined retrospective chart review and patient questionnaire study included po ... Full text Link to item Cite

Influence of Caretakers' Health Literacy on Delays to Traumatic Brain Injury Care in Uganda.

Journal Article Ann Glob Health · October 6, 2020 BACKGROUND: Traumatic brain injury (TBI) is a life-altering condition, and delays to care can significantly impact outcomes. In Uganda, where nurse shortages are prevalent, patients' family members are the primary caretakers of these patients and play an i ... Full text Open Access Link to item Cite

Condition still critical: Compliance and persistence with osteoporosis medications

Chapter · January 1, 2020 Despite multiple efforts at changing patient and provider behaviors to improve the use of pharmacologic medication for osteoporosis, the rates of compliance and persistence are still below desirable levels. This is a multifaceted problem that stems from a ... Full text Cite

Recommendations for the conduct of economic evaluations in osteoporosis: outcomes of an experts' consensus meeting organized by the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) and the US branch of the International Osteoporosis Foundation.

Journal Article Osteoporos Int · January 2019 UNLABELLED: Economic evaluations are increasingly used to assess the value of health interventions, but variable quality and heterogeneity limit the use of these evaluations by decision-makers. These recommendations provide guidance for the design, conduct ... Full text Link to item Cite

Impact of fractures on quality of life in patients with osteoporosis: a US cross-sectional survey.

Journal Article J Drug Assess · 2019 Objective: To evaluate the impact of osteoporosis-related fractures on health-related quality of life (HRQoL). Methods: Data were obtained from the 2016 Adelphi US Osteoporosis Disease Specific Programme™, a cross-sectional survey of physicians and their m ... Full text Link to item Cite

Sibling bereavement in late life

Journal Article · January 1, 2019 Elders are more likely to confront the death of a sibling than any other kinship bereavement. Yet we know almost nothing about the impact of sibling deaths on older adults. We used attachment theory to generate hypotheses about the impact of this life even ... Cite

Medication Decision-making in Osteoporosis: Can We Explain Why Patients Do Not Take Their Osteoporosis Medications?

Journal Article Curr Osteoporos Rep · December 2018 Patients at high risk of fracture often do not take medication for osteoporosis. Recent literature may give us some insights into why patients at high risk of fracture do not take medications for osteoporosis. ... Full text Link to item Cite

Persistence at 24 months with denosumab among postmenopausal women with osteoporosis: results of a prospective cohort study.

Journal Article Arch Osteoporos · August 7, 2018 UNLABELLED: Persistence with prescribed medications for chronic diseases is important; however, persistence with osteoporosis treatments is historically poor. In this prospective cohort study of postmenopausal women treated for osteoporosis in real-world c ... Full text Link to item Cite

Adherence to osteoporosis therapies

Chapter · January 1, 2018 Osteoporosis therapies reduce the risk of osteoporotic related fractures. Patients with poor persistence to osteoporosis medications are nonpersistent with nutritional interventions such as calcium or with medications such as statins for other asymptomatic ... Full text Cite

The importance of physical function to people with osteoporosis.

Journal Article Osteoporos Int · May 2017 UNLABELLED: There is increasing need to understand patient outcomes in osteoporosis. This article discusses that fracture in osteoporosis can lead to a cycle of impairment, driven by complex psychosocial factors, having a profound impact on physical functi ... Full text Link to item Cite

International Osteoporosis Foundation and European Calcified Tissue Society Working Group. Recommendations for the screening of adherence to oral bisphosphonates.

Journal Article Osteoporos Int · March 2017 UNLABELLED: Adherence to oral bisphosphonates is low. A screening strategy is proposed based on the response of biochemical markers of bone turnover after 3 months of therapy. If no change is observed, the clinician should reassess the adherence to the tre ... Full text Link to item Cite

Postmenopausal osteoporosis.

Journal Article Nat Rev Dis Primers · September 29, 2016 Osteoporosis is a metabolic bone disorder that is characterized by low bone mass and micro-architectural deterioration of bone tissue. Fractures of the proximal femur, the vertebrae and the distal radius are the most frequent osteoporotic fractures, althou ... Full text Link to item Cite

Association Between Gastrointestinal Events and Health Care Resource Utilization Among Patients with Osteoporosis: Analysis of a U.S. Managed Care Population.

Journal Article J Manag Care Spec Pharm · September 2015 BACKGROUND: Among patients on osteoporosis therapy, including oral bisphosphonates (BIS), upper gastrointestinal (GI) conditions have been linked with lower adherence to treatment and increased treatment discontinuation in clinical practice. Patients who a ... Full text Link to item Cite

Persistence at 12 months with denosumab in postmenopausal women with osteoporosis: interim results from a prospective observational study.

Journal Article Osteoporos Int · January 2015 UNLABELLED: To determine persistence with subcutaneous denosumab every 6 months in women being treated for osteoporosis, we conducted a single-arm prospective, observational study in the United States and Canada. Among 935 patients enrolled, 12-month persi ... Full text Link to item Cite

Patients who do not take their osteoporosis medications: Can we help them become compliant?

Chapter · January 1, 2015 Patients with chronic diseases frequently do not take their medications correctly. People with osteoporosis are no exception. Epidemiologic data show that noncompliance and nonpersistence should be serious concerns for healthcare professionals who treat th ... Full text Cite

Psychometric properties of the osteoporosis assessment questionnaire (OPAQ) 2.0: results from the multiple outcomes of raloxifene evaluation (MORE) study.

Journal Article BMC Musculoskelet Disord · November 17, 2014 BACKGROUND: We explored psychometric properties of the Osteoporosis Assessment Questionnaire 2.0 in terms of reliability, validity, and responsiveness with generic, clinical, demographic, and preference-based data collected from a population of postmenopau ... Full text Open Access Link to item Cite

Persistence at 12 months with denosumab in postmenopausal women with osteoporosis: interim results from a prospective observational study

Conference Osteoporosis International · September 19, 2014 Summary: To determine persistence with subcutaneous denosumab every 6 months in women being treated for osteoporosis, we conducted a single-arm prospective, observational study in the United States and Canada. Among 935 patients enrolled, 12-month persiste ... Full text Cite

Validation of the Osteoporosis-Specific Morisky Medication Adherence Scale in long-term users of bisphosphonates.

Journal Article Qual Life Res · September 2014 PURPOSE: To examine the psychometric properties and validity of the 8-item Osteoporosis-Specific Morisky Medication Adherence Scale (OS-MMAS-8) in postmenopausal women prescribed bisphosphonates (BPs) for at least 15 months. METHODS: A random sample of wom ... Full text Link to item Cite

Osteoporosis Assessment Questionnaire-Physical Function (OPAQ-PF): a psychometrically validated osteoporosis-targeted patient reported outcome measure of daily activities of physical function.

Journal Article Osteoporos Int · June 2014 UNLABELLED: The purpose of this study was to evaluate the measurement properties of the Osteoporosis Assessment Questionnaire-Physical Functioning (OPAQ-PF). Based on this study, the OPAQ-PF has confirmed unidimensionality and acceptable reliability, const ... Full text Link to item Cite

Reports of Depression in Older Women with Osteoporosis

Conference The American Journal of Geriatric Psychiatry · March 2014 Full text Cite

Development of the Osteoporosis Assessment Questionnaire--physical Function (OPAQ-PF): an osteoporosis-targeted, patient-reported outcomes (PRO) measure of physical function.

Journal Article Osteoporos Int · February 2014 UNLABELLED: We have developed a short, patient-reported outcome questionnaire--the Osteoporosis Assessment Questionnaire--Physical Function (OPAQ-PF)--that assesses the impact of osteoporosis on physical function. OPAQ-PF contains 15 items in three domains ... Full text Link to item Cite

Life course perspectives on intergenerational and generational connections

Journal Article · January 1, 2014 Life course perspectives are recent additions to the conceptual armamentarium of the social sciences. Nonetheless, they already have demonstrated their value for understanding temporal aspects of life patterns. At the individual level, life course perspect ... Full text Cite

Development of the osteoporosis assessment questionnaire - Physical function (OPAQ-PF): An osteoporosis-targeted, patient-reported outcomes (PRO) measure of physical function

Journal Article Osteoporosis International · January 1, 2014 Summary: We have developed a short, patient-reported outcome questionnaire - the Osteoporosis Assessment Questionnaire - Physical Function (OPAQ-PF)-that assesses the impact of osteoporosis on physical function. OPAQ-PF contains 15 items in three domains ( ... Full text Cite

Use of health-related quality of life measures to predict health utility in postmenopausal osteoporotic women: results from the Multiple Outcomes of Raloxifene Evaluation study.

Journal Article Health Qual Life Outcomes · November 5, 2013 BACKGROUND: The aim of this study is to examine the associations between health utility (HU), health-related quality of life (HRQoL), and patient characteristics in postmenopausal osteoporotic (PMO) women. METHODS: Baseline data from a subsample of 1,245 p ... Full text Link to item Cite

Primary non-adherence to bisphosphonates in an integrated healthcare setting.

Journal Article Osteoporos Int · September 2013 UNLABELLED: We estimated primary non-adherence to oral bisphosphonate medication and examined the factors associated with primary non-adherence. Nearly 30% of women did not pick up their new bisphosphonate within 60 days. Identifying barriers and developin ... Full text Link to item Cite

Compliance and Persistence with Osteoporosis Medications

Chapter · July 19, 2013 This chapter reviews five key controversies about research into compliance and persistence with osteoporosis treatments, and provides supporting evidence about those controversies. All researchers who study compliance and persistence with osteoporosis medi ... Full text Cite

Patient weighting of osteoporosis medication attributes across racial and ethnic groups: a study of osteoporosis medication preferences using conjoint analysis.

Journal Article Osteoporos Int · July 2013 UNLABELLED: We studied the ranking of osteoporosis (OP) medication attributes in a convenience sample of four different racial/ethnic groups in the United States. Our study showed that postmenopausal women differ in the ranking of OP medication attributes ... Full text Link to item Cite

THE IMPACT OF HEALTH BELIEFS ON OSTEOPOROSIS TREATMENT

Conference OSTEOPOROSIS INTERNATIONAL · April 1, 2013 Link to item Cite

Condition Critical: Compliance and Persistence with Osteoporosis Medications

Journal Article · January 1, 2013 Since the introduction of alendronate as the first bisphosphonate approved for osteoporosis prevention and treatment, compliance and persistence with osteoporosis medications has been a serious problem for healthcare professionals and patients alike. Initi ... Full text Cite

Oral bisphosphonates reduce the risk of clinical fractures in glucocorticoid-induced osteoporosis in clinical practice.

Journal Article Osteoporos Int · January 2013 UNLABELLED: This study aims to estimate bisphosphonate effectiveness by comparing fracture incidence over time on therapy in glucocorticoid-induced osteoporosis (GIO). From this observational study, alendronate and risedronate decreased clinical vertebral ... Full text Link to item Cite

Use of health-related quality of life measures to predict health utility in postmenopausal osteoporotic women: results from the Multiple Outcomes of Raloxifene Evaluation study.

Conference Health and quality of life outcomes · January 1, 2013 The aim of this study is to examine the associations between health utility (HU), health-related quality of life (HRQoL), and patient characteristics in postmenopausal osteoporotic (PMO) women. Baseline data from a subsample of 1,245 participants of the Mu ... Full text Cite

Psychometric properties of the Osteoporosis-specific Morisky Medication Adherence Scale in postmenopausal women with osteoporosis newly treated with bisphosphonates.

Journal Article Ann Pharmacother · May 2012 BACKGROUND: Poor adherence to oral osteoporosis medications is common. Strategies for improving adherence begin with identification of the problem. The 8-item Morisky Medication Adherence Scale for self-reported adherence to antihypertensive medications wa ... Full text Link to item Cite

Measuring health-related quality of life (HRQOL) in osteoporotic males using the Male OPAQ.

Journal Article Osteoporos Int · March 2012 UNLABELLED: The Male Osteoporosis Assessment Questionnaire (OPAQ™) is a health-related quality of life (HRQOL) instrument that can differentiate between men with and without fracture. The Male OPAQ™ is a reliable and validated instrument that may be utiliz ... Full text Link to item Cite

Development, reliability, and validity of a new Preference and Satisfaction Questionnaire.

Journal Article Value Health · December 2011 OBJECTIVES: Existing questionnaires that assess preference and/or satisfaction with postmenopausal bone loss treatments were reviewed and determined to be inadequate for the assessment of an oral pill versus a subcutaneous injection. The Preference and Sat ... Full text Link to item Cite

Late-life death and dying in 21st-century america

Journal Article · December 1, 2011 The social and medical changes of the twentieth century have been remarkable, and expectations for such change in the twenty-first century seem almost without bounds. Medical technology assists physicians to identify ways in which life can be extended. Thi ... Full text Cite

Older men's explanatory model for osteoporosis.

Journal Article Gerontologist · August 2011 PURPOSE: To explore the nature of men's experiences of osteoporosis by developing an understanding of men's explanatory models. DESIGN AND METHODS: This descriptive study invited community-residing male osteoporosis patients aged 50+ to participate in inte ... Full text Link to item Cite

Growing up with sickle cell disease: a pilot study of a transition program for adolescents with sickle cell disease.

Journal Article J Pediatr Hematol Oncol · July 2011 We implemented the Duke Sickle Cell Disease (SCD) Transition Program for adolescents with SCD and investigated the knowledge about SCD; concerns and emotions about transitioning; and the initial impact of the Transition Program. Thirty-three adolescents pa ... Full text Link to item Cite

SELF EFFICACY ACROSS BONE HEALTH BEHAVIORS IS NOT CONSISTENT

Journal Article OSTEOPOROSIS INTERNATIONAL · May 1, 2011 Link to item Cite

Understanding patient compliance and persistence with osteoporosis therapy.

Journal Article Drugs Aging · April 1, 2011 Chronic non-terminal diseases, including postmenopausal osteoporosis, are associated with poor treatment compliance and persistence. The longer a patient with osteoporosis complies and persists with treatment, the lower the risk of fracture. Retrospective ... Full text Link to item Cite

Oral bisphosphonate compliance and persistence: a matter of choice?

Journal Article Osteoporos Int · January 2011 Compliance to oral bisphosphonates is suboptimal, with negative consequences of increased healthcare utilization and less effective fracture risk reduction. Extending dose interval increased adherence only moderately. We used literature derived from multip ... Full text Link to item Cite

Factors Associated with Persistence with Teriparatide Therapy: Results from the DANCE Observational Study.

Journal Article J Osteoporos · 2011 Purpose. Determine patient-reported reasons for discontinuation with teriparatide. Methods. Patients taking teriparatide in a multicenter, prospective, and observational study were given three questionnaires: baseline, follow-up questionnaire 1 (QF1, 2 to ... Full text Link to item Cite

Compliance and persistence with osteoporosis medications: a critical review of the literature.

Journal Article Rev Endocr Metab Disord · December 2010 It is widely acknowledged that compliance and persistence with oral osteoporosis medications, particularly with bisphosphonates, is poor. Several excellent reviews have been written on compliance and persistence with osteoporosis medications and have discu ... Full text Link to item Cite

Adverse Health Outcomes in Men with Osteoporosis

Journal Article · December 1, 2010 The evidence about men and osteoporosis has changed over the last 30 years. Recent data suggest that at least 20% of people with osteoporosis are men. That means that 2 million men or more already have osteoporosis and another 12 million are at risk of the ... Full text Cite

Longitudinal change in clinical fracture incidence after initiation of bisphosphonates.

Journal Article Osteoporos Int · June 2010 SUMMARY: There are differences in the risk profile of patients prescribed alendronate, risedronate, or ibandronate. Observed reductions in fracture incidence over time suggest that the effectiveness of each bisphosphonate in clinical practice has been cons ... Full text Link to item Cite

Preference and satisfaction with a 6-month subcutaneous injection versus a weekly tablet for treatment of low bone mass.

Journal Article Osteoporos Int · May 2010 UNLABELLED: The Preference and Satisfaction Questionnaire (PSQ) compares patient preference and satisfaction between a 6-month subcutaneous injection and weekly oral tablet for treatment of bone loss. Patients preferred and were more satisfied with a treat ... Full text Link to item Cite

Adverse Health Outcomes in Men with Osteoporosis

Chapter · November 17, 2009 The evidence about men and osteoporosis has changed over the last 30 years. Recent data suggest that at least 20% of people with osteoporosis are men. That means that 2 million men or more already have osteoporosis and another 12 million are at risk of the ... Full text Cite

Weekly versus monthly drug regimens: 1-year compliance and persistence with bisphosphonate therapy.

Journal Article Curr Med Res Opin · August 2009 OBJECTIVE: To determine compliance and persistence with weekly risedronate and monthly ibandronate therapy. RESEARCH DESIGN AND METHODS: The IMS longitudinal prescription database was used to evaluate compliance (mean medication possession ratio), persiste ... Full text Link to item Cite

Correlation between symptoms and function in older adults with comorbidity.

Journal Article J Am Geriatr Soc · April 2009 OBJECTIVES: To describe the relationship between symptom scores and mobility function measures, assess whether symptom scores and disease scores are similarly associated with mobility function, and identify clusters of symptoms that are most strongly assoc ... Full text Link to item Cite

Depressive symptomatology and fracture risk in community-dwelling older men and women.

Journal Article Aging Clin Exp Res · December 2008 BACKGROUND AND AIMS: Previous studies suggest that depression increases risk of falls, low bone mineral density, and fractures. Our aim was to evaluate whether depressive symptomatology alone predicts 5- year clinical fracture risk in older adults. METHODS ... Full text Link to item Cite

Descriptive analysis of concomitant prescription medication patterns from 1999 to 2004 among US women receiving daily or weekly oral bisphosphonate therapy.

Journal Article Gend Med · December 2008 BACKGROUND: To improve medication-taking behavior, it is important to identify factors that may contribute to suboptimal compliance and persistence with osteoporosis medications. OBJECTIVE: The purpose of this descriptive analysis was to identify concurren ... Full text Link to item Cite

Osteoporosis prevention and management: an evidence-based review.

Journal Article Clin Obstet Gynecol · September 2008 Evidence-based guidelines that have been prepared by many professional organizations aimed at assisting the clinician in the initial evaluation of postmenopausal women who should be considered for bone mineral density evaluation by dual-energy x-ray absorp ... Full text Link to item Cite

Compliance and persistence with osteoporosis therapies.

Journal Article Curr Rheumatol Rep · April 2008 The US Food and Drug Administration has approved a diverse group of effective osteoporosis therapies. However, these therapies obviously only work when patients with osteoporosis take them. Data from retrospective observational databases have shown poor co ... Full text Link to item Cite

Reduced fracture rates observed only in patients with proper persistence and compliance with bisphosphonate therapies.

Journal Article South Med J · December 2007 Numerous studies have analyzed data from administrative claims databases to determine persistence and compliance with bisphosphonate therapy for osteoporosis; several of these studies have also examined how persistence and compliance with therapy affect fr ... Full text Link to item Cite

Osteoporosis

Journal Article · December 1, 2007 Full text Cite

Methodological considerations in using claims databases to evaluate persistence with bisphosphonates for osteoporosis.

Journal Article Curr Med Res Opin · October 2007 OBJECTIVE: To demonstrate that retrospective analyses of medication persistence require careful methodological approaches to assure accuracy and consistency across various types of databases. Bisphosphonates (BPs) are used as an example because of the avai ... Full text Link to item Cite

Compliance and persistence with osteoporosis therapies: We can do better

Journal Article Future Rheumatology · October 1, 2007 Full text Cite

A systematic review of persistence and compliance with bisphosphonates for osteoporosis.

Journal Article Osteoporos Int · August 2007 UNLABELLED: Fourteen reports utilizing data from de-identified administrative databases were reviewed. Studies contained at least one measure of patient persistence or compliance with bisphosphonates or bisphosphonates and other anti-osteoporosis medicatio ... Full text Link to item Cite

Do estrogen or selective estrogen receptor modulators improve quality of life for women with postmenopausal osteoporosis?

Journal Article Curr Osteoporos Rep · March 2007 Osteoporotic fractures result in significant deficits in health-related quality of life (HRQOL). The accumulation of deficits resulting from osteoporosis and fractures is now recognized as a major cause of reduced HRQOL in women after the menopause and in ... Full text Link to item Cite

A claims database analysis of persistence with alendronate therapy and fracture risk in post-menopausal women with osteoporosis.

Journal Article Curr Med Res Opin · March 2007 OBJECTIVE: To explore the relationship between persistence with alendronate therapy and fracture rates in women with postmenopausal osteoporosis. RESEARCH DESIGN AND METHODS: Claims data from a large US health plan database were used to examine persistence ... Full text Link to item Cite

European women's preference for osteoporosis treatment: influence of clinical effectiveness and dosing frequency.

Journal Article Curr Med Res Opin · December 2006 OBJECTIVE: To determine participant preference for weekly versus monthly bisphosphonate therapy for osteoporosis after being informed about differences in fracture efficacy. DESIGN: 20-minute, semi-structured, face-to-face or telephone interviews. Two bisp ... Full text Link to item Cite

Patient preference and adherence: comparative US studies between two bisphosphonates, weekly risedronate and monthly ibandronate.

Journal Article Curr Med Res Opin · December 2006 OBJECTIVES: To determine how patients' preferences for weekly versus monthly bisphosphonate therapy is influenced by their knowledge of the medication's proven fracture efficacy. An additional objective is to determine whether patient adherence to therapy ... Full text Link to item Cite

Osteoporosis and depression: a historical perspective.

Journal Article Curr Osteoporos Rep · December 2006 In the early 1980s, researchers studying osteoporosis noted that depression was one of the major negative consequences of bone loss and fractures. These researchers believed that osteoporosis and fractures occurred first, causing a reactive depression. Mea ... Full text Link to item Cite

Medication adherence: a challenge for patients with postmenopausal osteoporosis and other chronic illnesses.

Conference J Manag Care Pharm · July 2006 OBJECTIVE: To define medication adherence and describe the limitations of various assessment methods, reasons for nonadherence to medications used to manage chronic illness, the impact of nonadherence to osteoporosis medications, and strategies for improvi ... Full text Link to item Cite

How can osteoporosis patients benefit more from their therapy? Adherence issues with bisphosphonate therapy.

Journal Article Ann Pharmacother · June 2006 OBJECTIVE: To review the evidence on adherence with bisphosphonates and evolving dosing strategies for osteoporosis treatment. DATA SOURCES: Articles were identified by searching MEDLINE (1975-December 2005) using the following terms: osteoporosis, postmen ... Full text Link to item Cite

An evaluation of patient preferences for osteoporosis medication attributes: results from the PREFER-US study.

Journal Article Curr Med Res Opin · May 2006 OBJECTIVE: To evaluate preferences for eight medication attributes that women may consider when evaluating prescription osteoporosis medications. RESEARCH DESIGN AND METHODS: The eligible sample consisted of women aged 50 years or older who responded to th ... Full text Link to item Cite

Initial experience with teriparatide in the United States.

Journal Article Curr Med Res Opin · April 2006 Teriparatide has been commercially available in the United States (US) for over 3 years. This summary spans the early experience with this therapy. As of December 31, 2005, over 235 000 patients had filled a prescription for teriparatide world-wide. Data c ... Full text Link to item Cite

Update on male osteoporosis

Journal Article Advanced Studies in Medicine · April 1, 2006 PURPOSE: Fragility fractures are increasingly recognized as an important cause of morbidity and mortality in men. This review focuses on the potential causes, means of diagnosis, and available treatment for male osteoporosis. EPIDEMIOLOGY: More than 2 mill ... Cite

Approaches to patient education: emphasizing the long-term value of compliance and persistence.

Journal Article Am J Med · April 2006 Approximately 50% of patients with chronic disease do not obtain optimal clinical benefit from treatment because of poor compliance with medication regimens. Lack of compliance is associated with poor clinical outcomes, increased hospitalizations, lower qu ... Full text Link to item Cite

Review of adherence to medications for the treatment of osteoporosis.

Journal Article Curr Osteoporos Rep · March 2006 One of the major challenges of successful osteoporosis management is poor patient adherence to current therapies. Individuals who are nonadherent have significant consequences of reduced bone mineral density response, reduced bone marker suppression, and i ... Full text Link to item Cite

Rationale, objectives and design of the Direct Analysis of Nonvertebral Fracture in the Community Experience (DANCE) study.

Journal Article Osteoporos Int · January 2006 The experience in randomized placebo-controlled clinical trials may differ from that in community practice. The pivotal teriparatide [rhPTH(1-34)] studies were initiated when few therapeutic options for osteoporosis were available. The Direct Analysis of N ... Full text Link to item Cite

Introduction to osteoporosis: From pathogenesis to prevention and treatment strategies

Journal Article American Journal of Obstetrics and Gynecology · January 1, 2006 Full text Cite

Elevated calcium requirements for women and unique approaches to improving calcium adherence.

Journal Article J Reprod Med · November 2005 Recent analyses from the Women's Health Initiative have shed new light on the importance of adequate calcium and vitamin D intake to women's bone health. This new information reveals the need for behavioral change in women's calcium and vitamin D intake. T ... Link to item Cite

How can osteoporosis patients get more out of their therapy?

Journal Article American Family Physician · 2005 Cite

The downward spiral of osteoporosis

Journal Article Annals of Internal Medicine · 2005 Cite

The influence of osteoporosis on the marital relationship of older couples

Journal Article Journal of Applied Gerontology · December 1, 2004 Thirty-four older wives and their husbands participated in interviews about adaptation to the wives' osteoporosis and its influence on their relationship. For most couples, the wives' osteoporosis resulted in changes in the structure of their marital relat ... Full text Cite

Group treatment improves trunk strength and psychological status in older women with vertebral fractures: results of a randomized, clinical trial.

Journal Article J Am Geriatr Soc · September 2004 OBJECTIVES: To assess whether group exercise and coping classes reduce physical and psychological impairments and functional disability in older women with prevalent vertebral fractures (VFs). DESIGN: Randomized, controlled trial (modified cross-over) with ... Full text Link to item Cite

Osteoporosis self-management: Choices For Better Bone Health.

Journal Article South Med J · June 2004 Despite recent pharmacologic advances in the prevention and treatment of osteoporosis, the disease remains incurable. Effective disease management ultimately lies in the hands of the individual patient, who must take responsibility for key health behaviors ... Full text Link to item Cite

Age-related declines in activity level: the relationship between chronic illness and religious activities.

Journal Article J Gerontol B Psychol Sci Soc Sci · November 2003 OBJECTIVES: When they are faced with major life transitions such as worsening health, older adults may selectively withdraw from activities. Because of the importance of religion to a large proportion of the elderly population, research is needed to determ ... Full text Link to item Cite

APOE epsilon4 as a predictor of subjective quality of life in a biracial older person community sample.

Journal Article J Aging Health · November 2003 UNLABELLED: The epsilon4 allele of apolipoprotein E (APOE) has been associated with health-related outcomes that may adversely affect quality of life (QOL) in older adults. In the absence of published information, we sought to determine whether the epsilon ... Full text Link to item Cite

Osteoporosis and quality of life psychosocial outcomes and interventions for individual patients.

Journal Article Clin Geriatr Med · May 2003 Despite the substantial psychosocial impact of osteoporosis, little research has evolved in this area. Early reports conceptualized these nonskeletal problems as psychosocial in nature, but more recent investigations focus on health-related quality of life ... Full text Link to item Cite

Chronic pain in later life women: issues and challenges from the research literature.

Journal Article J Am Med Womens Assoc (1972) · 2002 Because research on chronic pain in older adults comes from many disciplines, existing information about geriatric pain is widely scattered. In order to establish a foundation from which to construct future research and interventions for older women and me ... Link to item Cite

Disability as a function of social networks and support in elderly African Americans and Whites: the Duke EPESE 1986--1992.

Journal Article J Gerontol B Psychol Sci Soc Sci · May 2001 OBJECTIVES: We examined the association of structural and functional aspects of social relationships with change in disability, and the degree to which race modifies these associations. METHODS: Data are from a population-based sample of 4,136 African Amer ... Full text Link to item Cite

The nonskeletal consequences of osteoporotic fractures. Psychologic and social outcomes.

Journal Article Rheum Dis Clin North Am · February 2001 The prevalence of osteoporosis is rising as the population of the United States and other developed countries ages. These increasing numbers of people have motivated pharmaceutical companies to develop and market several antiresorptive medications that can ... Full text Link to item Cite

Racial differences in use of cancer prevention services among older Americans.

Journal Article J Am Geriatr Soc · July 2000 CONTEXT: Racial differences in receipt of cancer prevention services may be related to poorer outcomes for minorities. Understanding reasons for such differences could help target appropriate interventions. OBJECTIVES: To determine if racial differences ex ... Full text Link to item Cite

Correlates and consequences of chronic pain in older adults.

Journal Article Geriatr Nurs · 2000 Chronic pain is a frequent challenge to older adults' coping skills. Despite the widespread occurrence of chronic geriatric pain, no comprehensive body of literature on this topic exists. Instead, research on chronic pain is scattered across disciplines an ... Full text Link to item Cite

Effects of educational materials concerning osteoporosis on women's knowledge, beliefs, and behavior.

Journal Article Am J Health Promot · 2000 PURPOSE: This study examined the effects of brief written educational materials on osteoporosis-related knowledge, beliefs, and behaviors. The study also examined whether observed effects varied as a function of one's stage in the precaution adoption proce ... Full text Link to item Cite

Timed loaded standing: a measure of combined trunk and arm endurance suitable for people with vertebral osteoporosis.

Journal Article Osteoporos Int · 2000 Chronic back tiredness or fatigue is a common complaint of people who have a history of osteoporotic vertebral fracture. Trunk muscle endurance has not been studied in people with vertebral osteoporosis, partly due to the lack of assessment tools. We devel ... Full text Link to item Cite

Factors associated with self-rated health in patients with Paget's disease of bone.

Journal Article J Bone Miner Res · October 1999 Multiple studies show that poor self-rated health (SRH) increases the risk of mortality up to 5-fold when compared to excellent SRH. This powerful association remains even with objective health status and risk factors controlled. However, few studies have ... Full text Link to item Cite

Spinal deformity and mobility self-confidence among women with osteoporosis and vertebral fractures.

Journal Article Aging (Milano) · August 1999 This study evaluated the direct and indirect effects of spinal deformity on confidence in mobility among 185 older women with osteoporosis and vertebral fractures. We administered multidimensional tests of physical and psychosocial impairment and function ... Full text Link to item Cite

Association of race and other potential risk factors with nonvertebral fractures in community-dwelling elderly women.

Journal Article Am J Epidemiol · June 1, 1999 This study determined potential associations of sociodemographic, lifestyle, health, and drug use factors known to affect bone metabolism with incident nonvertebral fractures. The baseline sample consisted of 2,590 female, nonproxy subjects from the Duke E ... Full text Link to item Cite

Reliability of physical performance tests in four different randomized clinical trials.

Journal Article Arch Phys Med Rehabil · May 1999 OBJECTIVES: (1) To assess the test-retest reliability of physical performance tests in subject groups with different levels of impairment and disability, and (2) to assess the stability of these tests over different time intervals. DESIGN: Test-retest, rep ... Full text Link to item Cite

Quality of life and Parkinson's disease.

Journal Article J Gerontol A Biol Sci Med Sci · April 1999 BACKGROUND: People with Parkinson's disease (PD) have a progressive loss of function eventually leading to severe disability. Although PD would be expected to have a profound impact on an individual's psychosocial health, there is relatively limited resear ... Full text Link to item Cite

Spinal deformity and mobility self-confidence among women with osteoporosis

Journal Article Aging: Clinical and Experimental Research · 1999 Cite

Using a short food frequency questionnaire to estimate dietary calcium consumption: a tool for patient education.

Journal Article Arthritis Care Res · December 1998 OBJECTIVE: To develop a short food frequency questionnaire (FFQ) assessing calcium intake and a prediction equation for estimating total calcium intake from the short FFQ. METHODS: Data were collected from 536 women via mailed questionnaires at 3 time poin ... Full text Link to item Cite

Private health insurance coverage and disability among older Americans.

Journal Article J Gerontol B Psychol Sci Soc Sci · September 1998 OBJECTIVES: This study examines the relationship between the lack of private supplemental health insurance coverage and the development of disability among adults aged 65 and older. METHODS: Data are from the baseline and six follow-up waves of the Duke Es ... Full text Link to item Cite

Managing patients with complications of osteoporosis.

Journal Article Endocrinol Metab Clin North Am · June 1998 This article reviews the impact of osteoporosis on quality of life. It defines specific impairments and suggests how best to minimize the impact of osteoporosis on patients' daily lives. Specific issues such as a spinal deformity, limitations on activities ... Full text Link to item Cite

Peyronie's disease is associated with Paget's disease of bone.

Journal Article J Bone Miner Res · June 1997 Peyronie's disease is an idiopathic disorder in which an inflammatory fibrosis occurs in the tunica albuginea of the corpora cavernosa which causes the erect penis to become deformed. Peyronie's disease has a prevalence of 1% in men over age 50 years. Page ... Full text Link to item Cite

Memory complaint as a predictor of cognitive decline: a comparison of African American and White elders.

Journal Article J Aging Health · May 1997 Of a representative, racially mixed community sample of older adults in North Carolina, 59% of Whites and 49% of African Americans reported worsening memory. The complaint about memory was positively correlated with age, depressive symptomatology, and phys ... Full text Link to item Cite

Spousal support of older women with osteoporotic pain: Congruity of perceptions

Journal Article Journal of Women and Aging · January 1, 1997 Thirty-four couples were interviewed to assess the congruity of husbands’ and wives’ perceptions of the wives’ osteoporotic pain and the exchange of instrumental support within the marital relationship. Moderate correlations were found between the husbands ... Full text Cite

Paget's disease of bone and quality of life.

Journal Article J Bone Miner Res · December 1996 Little is known about how Paget's disease of bone affects quality of life. To better understand the relative impact of factors on quality of life, we mailed a brief survey to 2000 people randomly selected from the Paget's Foundation mailing list. The sampl ... Full text Link to item Cite

Global self-ratings of health and mortality: hazard in the North Carolina Piedmont.

Journal Article J Clin Epidemiol · September 1996 We analyzed the first 5 years of surveillance data from the Established Population for the Epidemiologic Studies of the Elderly (EPESE) in the Piedmont of North Carolina (n = 4162) to estimate the effect of a global self-rating of health on survival. Covar ... Full text Link to item Cite

Do racial differences in hypertension persist in successful agers? Findings from the MacArthur Study of Successful Aging.

Journal Article J Aging Health · May 1996 The objective of this study was to determine whether racial differences in hypertension in a random sample of community-dwelling older adults also remained significant in a sample of successful agers. Data for the random sample of community-dwelling older ... Full text Link to item Cite

Introduction.

Journal Article Gerontologist · April 1996 Full text Link to item Cite

Osteoporosis prevention in premenopausal women: using a stage model approach to examine the predictors of behavior.

Journal Article Health Psychol · March 1996 The precaution adoption process model was used to examine the predictors of 2 behaviors recommended to reduce the risk of developing osteoporosis: calcium consumption and weight-bearing exercise. A total of 452 premenopausal women completed a mailed questi ... Full text Link to item Cite

The clinical impact of vertebral fractures: quality of life in women with osteoporosis.

Journal Article Bone · March 1996 Osteoporosis has obvious physical and functional consequences such as kyphosis, restricted range of motion, and pain. What are not so obvious are the psychosocial sequelae that result from this metabolic bone disease. Many patients in the initial phases of ... Full text Link to item Cite

Black-white and urban-rural differences in stability of household composition among elderly persons.

Journal Article J Gerontol B Psychol Sci Soc Sci · September 1995 The dynamic nature of household composition in a population of elderly persons, with particular focus on Black-White and urban-rural differences, is described in this study. The Duke EPESE is a stratified, random household sample (N = 4,162) of elderly per ... Full text Link to item Cite

Functional and mobility impairments associated with Paget's disease of bone.

Journal Article J Am Geriatr Soc · May 1995 OBJECTIVE: To determine if patients with Paget's disease of bone involving the tibia, femur, and/or acetabular portion of the ilium had more impairments in function and mobility than age- and sex-matched control subjects. PATIENTS AND METHODS: A case contr ... Full text Link to item Cite

Chronic musculoskeletal pain: Older women and their coping strategies

Journal Article Journal of Women and Aging · November 14, 1994 Two diseases, osteoporosis and osteoarthritis, are responsible for a majority of the chronic musculoskeletal pain that older women experience. Osteoporosis is the metabolic bone disease most common in older women and is responsible for fractures, kyphosis, ... Full text Cite

Self-rated health and mortality in the high-functioning elderly--a closer look at healthy individuals: MacArthur field study of successful aging.

Journal Article J Gerontol · May 1994 BACKGROUND: This study tested the predictive value of self-rated health on 3-year mortality, with attention focused on healthy, high-functioning elders. METHODS: Data from the MacArthur Field Study of Successful Aging were utilized. Subjects were 70-79-yea ... Full text Link to item Cite

Recurrent syncope as a chronic disease: preliminary validation of a disease-specific measure of functional impairment.

Journal Article J Gen Intern Med · April 1994 BACKGROUND: A disease-specific measure of functional health in syncope would provide an important outcome measure for use either in clinical trials or in the clinical management of patients with recurrent syncope. METHODS AND MEASUREMENTS: In a previous st ... Full text Link to item Cite

Association of osteoporotic vertebral compression fractures with impaired functional status.

Journal Article Am J Med · June 1993 PURPOSE: To determine if vertebral compression fractures in elderly women were associated with impairments in physical, functional, and psychosocial performance. SUBJECTS AND METHODS: Ten white women with confirmed vertebral compression fractures were age- ... Full text Link to item Cite

Expenditures in caring for patients with dementia who live at home.

Journal Article Am J Public Health · March 1993 OBJECTIVES: Given the national interest in progressive dementia, we estimated expenditures incurred in caring for dementia patients who live at home. METHODS: Primary caregivers of 264 patients from a university-based memory disorders clinic were interview ... Full text Link to item Cite

CES-D: cutpoint or change score?

Journal Article J Am Geriatr Soc · March 1993 Full text Link to item Cite

Social service interventions for caregivers of patients with dementia: impact on health care utilization and expenditures.

Journal Article J Am Geriatr Soc · February 1993 OBJECTIVES: An intervention, which had as its primary goal the enhancement of compliance to social work recommendations, was shown to produce extremely high rates of compliance. This report addresses the secondary objective of the study: to evaluate the im ... Full text Link to item Cite

Psychosocial functioning and osteoporosis in late life: Results of a multidisciplinary intervention

Journal Article Journal of Women's Health · January 1, 1993 Objective: To determine whether older women and men with osteoporosis who participated in a medica. evaluation program showed improvement in psychosocial functioning when compared to a age-, gender-, and disease severity-matched group of osteoporotic patie ... Full text Cite

Expenditures in caring for patients with dementia

Journal Article American Journal of Public Health · 1993 Cite

Physician-related barriers to breast cancer screening in older women.

Journal Article J Gerontol · November 1992 Despite evidence that annual mammographic screening in women 50 years and older reduces mortality, surveys of physicians and patients have repeatedly demonstrated that annual screening mammography is not performed. The fundamental question addressed in thi ... Link to item Cite

Special care units: a typology of care settings for memory-impaired older adults.

Journal Article Gerontologist · August 1991 After rating 55 nursing homes in five states, we created a typology of care settings that included eight distinct types of units designed to care for memory-impaired older adults. SCUs appeared to be associated with higher quality care than were traditiona ... Full text Link to item Cite

Osteoporosis in late life: does health locus of control affect psychosocial adaptation?

Journal Article J Am Geriatr Soc · July 1991 Osteoporosis, a metabolic bone disease most prevalent in older adults, is a major public health problem. Although management of osteoporosis through diet, exercise, and medication has improved, little is known about the psychosocial consequences of this di ... Full text Link to item Cite

Literacy and laryngectomy: how should one treat head and neck cancer in patients who cannot read or write?

Journal Article South Med J · February 1991 The entire population of otolaryngologists and radiation oncologists (N = 192) in active practice in the state of North Carolina were surveyed to assess their level of awareness of illiteracy among adults in the United States and to determine whether these ... Link to item Cite

Impairment of physical and psychosocial function in recurrent syncope.

Journal Article J Clin Epidemiol · 1991 Physical and psychosocial function have rarely been assessed in syncope. We used two valid and reliable measures of health status, the Sickness Impact Profile (SIP) and the Symptom Checklist 90 (SCL-90-R), to assess functional impairment in 62 patients wit ... Full text Link to item Cite

Life Course Perspectives on Intergenerational and Generational Connections

Journal Article Marriage and Family Review · 1991 Cite

Breast cancer screening in older women: practices and barriers reported by primary care physicians.

Journal Article J Am Geriatr Soc · January 1991 Annual mammography, in combination with clinical breast examinations, can reduce mortality from breast cancer. However, surveys of both patients and physicians suggest that mammography is underutilized. This study examined whether physicians' reported brea ... Full text Link to item Cite

Late-life sibling relationships: does race affect typological distribution?

Journal Article Gerontologist · December 1990 Using a typology of sibling relationships in old age (Gold, 1989a), effects of race on distribution of relationships were studied. Differences between elderly white and black sibling pairs on several dimensions were also examined. Analyses of interview dat ... Full text Link to item Cite

Relationship classification using grade of membership analysis: a typology of sibling relationships in later life.

Journal Article J Gerontol · March 1990 The results of a comparison of two typologies of sibling relationships in old age are reported. Both analyses rely on the same data collected in individual interviews with adults over the age of 65. The first typology was constructed using constant compara ... Full text Link to item Cite

Generational Solidarity

Journal Article American Behavioral Scientist · September 1989 Full text Cite

Treatment of osteoporosis. The psychological impact of a medical education program on older patients.

Journal Article J Am Geriatr Soc · May 1989 Participants in a therapeutic program for osteoporosis were studied to determine if program participation improved psychological outcomes. The 4-day program included intensive education about the disease and its prognosis, physical therapy education, nutri ... Full text Link to item Cite

Home or Institutional Care: Which is Better?

Journal Article Gerontologist · January 1, 1989 Full text Cite

Sibling relationships in old age: a typology.

Journal Article Int J Aging Hum Dev · 1989 Sibling interactions in old age have received limited attention in social science literature. This article examines the different kinds of relationships which exist between siblings in old age and the ways in which each type meets or ignores the social and ... Full text Link to item Cite

The prevention of elder abuse: An educational curriculum

Journal Article Family Relations · 1989 Cite

The Prevention of Elder Abuse: An Educational Model

Journal Article Family Relations · January 1989 Full text Cite

Siblings in Old Age: Something Special

Journal Article Canadian Journal on Aging / La Revue canadienne du vieillissement · January 1, 1987 This paper reports the findings of a qualitative examination of sibling relationships in old age. Interviews with sixty people over the age of sixty-five revealed that interactions with sisters and brothers took on new meaning in late life. A shared histor ... Full text Cite

Osteoporosis.

Journal Article J Ky Med Assoc · August 1973 Link to item Cite