Scholars@Duke
Cynthia Lea Green

Cynthia Lea Green

Associate Professor of Biostatistics & Bioinformatics
Biostatistics & Bioinformatics, Division of Biostatistics
green054@mc.duke.edu
Duke Box 3850, Durham, NC 27710
200 Morris Street, 6112 200 Morris, Durham, NC 27701

Selected Publications

Referral, enrollment, and health care use in a comprehensive patient-centered management program for osteoarthritis of the hip and knee

Journal Article Osteoarthritis and Cartilage Open · December 1, 2024 Objective: Osteoarthritis management programs (OAMPs) have become a more common way to deliver patient-centered care. However, there is limited information on real-world use of these programs to guide implementation, payment policy, accessibility, and scal ... Full text Cite

Association of rurality and health professional shortages with the clinicopathologic characteristics of melanoma in North Carolina.

Journal Article J Rural Health · October 3, 2024 PURPOSE: To assess rural-urban and health professional shortage area (HPSA)-related influences on the characteristics of melanoma in North Carolina. METHODS: We conducted a single-center retrospective cohort study of patients living in North Carolina with ... Full text Link to item Cite

Static Versus Articulating Spacer: Does Infectious Pathogen Type Affect Treatment Success?

Journal Article Clin Orthop Relat Res · October 1, 2024 BACKGROUND: Treatment with a static or an articulating antibiotic-containing spacer is a common strategy for treating periprosthetic joint infection (PJI), yet many patients have persistent infections after spacer treatment. Although previous studies have ... Full text Link to item Cite

Late follow-up for a randomized trial of surgical treatment of tricuspid valve regurgitation in patients undergoing left ventricular assist device implantation.

Journal Article J Thorac Cardiovasc Surg · September 21, 2024 BACKGROUND: We previously reported that concurrent tricuspid valve surgery (TVS) was not associated with a lower incidence of early right heart failure (RHF) in patients undergoing durable left ventricular assist device (LVAD) implantation. This follow-up ... Full text Link to item Cite

Metformin use associated with lower rate of hospitalization for influenza in individuals with diabetes.

Journal Article Diabetes Obes Metab · August 2024 AIM: To investigate if patients with diabetes taking metformin have better outcomes versus those not taking metformin following an emergency room visit for influenza. METHODS: Using electronic medical records, we performed a retrospective chart review of a ... Full text Link to item Cite

Tuberculosis Is Associated with Chronic Hypoxemia among Kenyan Adults (CHAKA): A Case-Control Study.

Journal Article Ann Am Thorac Soc · August 2024 Rationale: Data on risk factors for chronic hypoxemia in low- and middle-income countries are lacking. Objectives: We aimed to quantify the association between potential risk factors and chronic hypoxemia among adults hospitalized in Kenya. Methods: A hosp ... Full text Link to item Cite

Feasibility of a Novel Augmented 6-Minute Incremental Step Test: A Simplified Cardiorespiratory Fitness Assessment Tool.

Journal Article JACC Adv · August 2024 BACKGROUND: The cardiopulmonary exercise test (CPET) is considered a gold standard in assessing cardiorespiratory fitness (CRF) but has limited accessibility due to competency requirements and cost. Incorporating portable sensor devices into a simple bedsi ... Full text Link to item Cite

Single-shot interscalene block with liposomal bupivacaine vs. non-liposomal bupivacaine in shoulder arthroplasty.

Journal Article J Shoulder Elbow Surg · July 20, 2024 BACKGROUND: Regional anesthesia is a valuable component of multimodal pain control in total shoulder arthroplasty (TSA), and multiple interscalene block anesthetic options exist, including nonliposomal interscalene bupivacaine (NLIB) and liposomal intersca ... Full text Link to item Cite

Association of RBC Transfusion Thresholds and Outcomes in Medical Patients With Acute Respiratory Failure Supported With Extracorporeal Membrane Oxygenation: A Single-Center Retrospective Cohort Study.

Journal Article Chest · July 8, 2024 BACKGROUND: The hemoglobin value to trigger RBC transfusion for patients receiving venovenous extracorporeal membrane oxygenation (ECMO) is controversial. Previous guidelines recommended transfusing to a normal hemoglobin level, but recent studies suggest ... Full text Link to item Cite

Racial Disparities Exist in 90-Day Unplanned Return to the Emergency Department Following Orthopaedic Trauma Surgery.

Journal Article J Orthop Trauma · July 1, 2024 OBJECTIVES: Racial disparities in healthcare outcomes exist, including in orthopaedic trauma care. The aim of this study was to determine the impact of race, social deprivation, and payor status on 90-day emergency department (ED) revisits among orthopaedi ... Full text Link to item Cite

Sacubitril/valsartan and cardiovascular biomarkers among patients with recent COVID-19 infection: The PARACOR-19 randomized clinical trial.

Journal Article Eur J Heart Fail · June 2024 AIMS: The PARACOR-19 randomized controlled trial (RCT) was designed to examine the effects of sacubitril/valsartan on markers of cardiac injury, inflammation, structure, and function among patients who have recovered from acute coronavirus disease 2019 (CO ... Full text Link to item Cite

Multisite Study of the Management of Musculoskeletal Infection After Trauma: The MMUSKIT Study.

Journal Article Open Forum Infect Dis · June 2024 BACKGROUND: The optimal duration and choice of antibiotic for fracture-related infection (FRI) is not well defined. This study aimed to determine whether antibiotic duration (≤6 vs >6 weeks) is associated with infection- and surgery-free survival. The seco ... Full text Link to item Cite

Surgical Treatment of Tricuspid Valve Regurgitation in Patients Undergoing Left Ventricular Assist Device Implantation: Interim analysis of the TVVAD trial.

Journal Article J Thorac Cardiovasc Surg · May 2024 OBJECTIVES: Right heart failure remains a serious complication of left ventricular assist device therapy. Many patients presenting for left ventricular assist device implantation have significant tricuspid regurgitation. It remains unknown whether concurre ... Full text Link to item Cite

A Framework for Studying Healthcare Equity in Adolescent Idiopathic Scoliosis: Scoping Review and Meta-Analysis of Existing Literature.

Journal Article J Am Acad Orthop Surg · May 1, 2024 INTRODUCTION: Health inequities remain a notable barrier for pediatric patients, especially in conditions such as adolescent idiopathic scoliosis (AIS), where the efficacy of nonsurgical treatment is dependent on early diagnosis and referral to a specialis ... Full text Link to item Cite

The burden of severe asthma in sub-Saharan Africa: Findings from the African Severe Asthma Project.

Journal Article J Allergy Clin Immunol Glob · May 2024 BACKGROUND: Severe asthma is associated with high morbidity, mortality, and health care utilization, but its burden in Africa is unknown. OBJECTIVE: We sought to determine the burden (prevalence, mortality, and activity and work impairment) of severe asthm ... Full text Link to item Cite

Association between sleep dysfunction and Patient-Reported Outcomes Measurement Information System scores in patients with rotator cuff tears.

Journal Article J ISAKOS · April 2024 OBJECTIVES: The purpose of this study was to utilize Patient-Reported Outcomes Measurement Information System (PROMIS) sleep scores to determine the prevalence of sleep dysfunction and its association with other PROMIS scores in patients with rotator cuff ... Full text Link to item Cite

Incorporation of Drone Technology Into the Chain of Survival for OHCA: Estimation of Time Needed for Bystander Treatment of OHCA and CPR Performance.

Journal Article Circ Cardiovasc Qual Outcomes · April 2024 BACKGROUND: Drone-delivered automated external defibrillators (AEDs) hold promises in the treatment of out-of-hospital cardiac arrest. Our objective was to estimate the time needed to perform resuscitation with a drone-delivered AED and to measure cardiopu ... Full text Link to item Cite

Nonoperative Management, Repair, or Reconstruction of the Medial Collateral Ligament in Combined Anterior Cruciate and Medial Collateral Ligament Injuries-Which Is Best? A Systematic Review and Meta-analysis.

Journal Article Am J Sports Med · February 2024 BACKGROUND: Combined injury of the anterior cruciate ligament (ACL) and the medial collateral ligament (MCL) is a common injury pattern and accounts for 20% of all ligamentous knee injuries. Despite advancements in surgical technique, there is no up-to-dat ... Full text Link to item Cite

Outcomes after total ankle arthroplasty with an average follow-up of 10 years: A systematic review and meta-analysis.

Journal Article Foot Ankle Surg · January 2024 BACKGROUND: The literature demonstrating positive outcomes after total ankle arthroplasty (TAA) is mounting. However, the long-term outcomes of TAA (≥ 10 years) remain minimally reported. The purpose of this systematic review and meta-analysis was to evalu ... Full text Link to item Cite

Supplemental Patch Testing Identifies Allergens Missed by Standard Screening Series.

Journal Article Dermatitis · 2024 Background: Supplemental patch testing is an adjunct to standard patch test screening series. Objective: To determine the demographics, characteristics, frequency, relevance, and interpretation of patch test reactions for supplemental patch testing. Method ... Full text Link to item Cite

Positive Outliers: A Mixed Methods Study of Resiliency to Childhood Obesity in High-Risk Neighborhoods.

Journal Article Acad Pediatr · 2024 OBJECTIVE: Despite the high prevalence of obesity and the clustering of risk by neighborhood, few studies have examined characteristics which promote healthy child weight in neighborhoods with high obesity risk. We aimed to identify protective factors for ... Full text Link to item Cite

Sociodemographic Trends in Telemedicine Visit Completion in Spine Patients During the COVID-19 Pandemic.

Journal Article Spine (Phila Pa 1976) · November 1, 2023 STUDY DESIGN: Retrospective cohort study. OBJECTIVE: This study identifies potential disparities in telemedicine utilization in the wake of the COVID-19 pandemic and its aftermath in patients receiving spine surgery. SUMMARY OF BACKGROUND DATA: COVID-19 le ... Full text Open Access Link to item Cite

Colchicine for the Prevention of Recurrent Arrhythmia After Catheter Ablation of Atrial Fibrillation: Results of a Single-Center, Retrospective Study.

Journal Article Am J Cardiovasc Drugs · November 2023 BACKGROUND: There is evidence to suggest that colchicine reduces the risk of recurrent atrial fibrillation (AF) after catheter ablation; however, the tolerability and safety of colchicine in routine practice is unknown. METHODS: Patients undergoing cathete ... Full text Link to item Cite

The Association Between Sociodemographic Factors, Social Determinants of Health, and Spine Surgical Patient Portal Utilization.

Journal Article Clin Spine Surg · October 1, 2023 STUDY DESIGN: Retrospective cohort study. OBJECTIVE: To examine patient portal use among the surgical spine patient population across different sociodemographic groups and assess the impact of patient portal use on clinical outcomes. SUMMARY OF BACKGROUND ... Full text Open Access Link to item Cite

Multicenter study of universal prophylaxis versus pre-emptive therapy for patients at intermediate risk (R+) for CMV following heart transplantation.

Journal Article Clin Transplant · October 2023 INTRODUCTION: Heart transplant (HT) recipients with prior exposure to cytomegalovirus (CMV R+) are considered intermediate risk for CMV-related complications. Consensus guidelines allow for either universal prophylaxis (UP) or preemptive therapy (PET) (ser ... Full text Link to item Cite

Prevalence and phenotypic trajectories of hypoxaemia among hospitalised adults in Kenya: a single-centre, prospective cohort study.

Journal Article BMJ Open · September 18, 2023 OBJECTIVE: Global medical oxygen security is limited by knowledge gaps in hypoxaemia burden and oxygen access in low-income and middle-income countries. We examined the prevalence and phenotypic trajectories of hypoxaemia among hospitalised adults in Kenya ... Full text Open Access Link to item Cite

Sudden cardiac arrest response preparedness in Durham County schools.

Journal Article Cardiol Young · September 2023 Sudden cardiac arrest is an uncommon event with high morbidity and mortality. There are improved outcomes with early access to an automated external defibrillator and cardiopulmonary resuscitation. We assessed the availability of automated external defibri ... Full text Link to item Cite

Cast or Nail? Using a Preference-Based Tool for Shared Decision-Making in Pediatric Femoral Shaft Fracture Treatment.

Journal Article J Pediatr Orthop · September 1, 2023 BACKGROUND: Femoral shaft fractures are common injuries in children 2 to 7 years of age, with treatments ranging from casting to flexible intramedullary nails (FIN). Each treatment has unique attributes and outcomes are overall similar. Given equivalent ou ... Full text Link to item Cite

Ability of the respiratory ECMO survival prediction (RESP) score to predict survival for patients with COVID-19 ARDS and non-COVID-19 ARDS: a single-center retrospective study.

Journal Article J Intensive Care · September 1, 2023 The respiratory ECMO survival prediction (RESP) score is used to predict survival for patients managed with extracorporeal membrane oxygenation (ECMO), but its performance in patients with Coronavirus Disease 2019 (COVID-19) acute respiratory distress synd ... Full text Link to item Cite

Chronological trends in the causation of malignant mesothelioma: Fiber burden analysis of 619 cases over four decades.

Journal Article Environ Res · August 1, 2023 Malignant mesothelioma is a relatively rare malignancy with a strong association with prior asbestos exposure. A percentage of cases is not related to asbestos, and fiber analysis of lung tissue is a useful methodology for identifying idiopathic or spontan ... Full text Link to item Cite

U-Shaped Association Between Carboxyhemoglobin and Mortality in Patients With Acute Respiratory Distress Syndrome on Venovenous Extracorporeal Membrane Oxygenation.

Journal Article Crit Care Explor · August 2023 BACKGROUND: Carbon monoxide (CO) is an endogenous signaling molecule that activates cytoprotective programs implicated in the resolution of acute respiratory distress syndrome (ARDS) and survival of critical illness. Because CO levels can be measured in bl ... Full text Link to item Cite

Splanchnic Nerve Modulation Effects on Surrogate Measures of Venous Capacitance.

Journal Article J Am Heart Assoc · July 18, 2023 Background Splanchnic nerve modulation (SNM) is an emerging procedure to reduce cardiac filling pressures in heart failure. Although the main contributor to reduction in cardiac preload is thought to be increased venous capacitance in the splanchnic circul ... Full text Link to item Cite

Effect of Risk-Stratified Care on Disability Among Adults With Low Back Pain Treated in the Military Health System: A Randomized Clinical Trial.

Journal Article JAMA Netw Open · July 3, 2023 IMPORTANCE: Tailored treatments for low back pain (LBP) based on stratifying risk for poor prognosis have emerged as a promising approach to improve quality of care, but they have not been validated in trials at the level of individual randomization in US ... Full text Link to item Cite

Association of race and in-hospital outcomes following acute pulmonary embolism: A retrospective cohort study.

Journal Article Clin Cardiol · July 2023 BACKGROUND: Racial disparities in health care are well established, with Black patients frequently experiencing the most significant consequences of this inequality. Acute pulmonary embolism (PE) is increasing in incidence and an important cause of morbidi ... Full text Link to item Cite

Timing and Magnitude of Peak Body Mass Index and Peak Weight Velocity in Infancy Predict Body Mass Index at 2 Years in a Retrospective Cohort of Electronic Health Record Data.

Journal Article J Pediatr · June 2023 OBJECTIVES: To use growth data from electronic health records to describe and model infant growth (weight velocity and peak body mass index [pBMI]) characteristics. STUDY DESIGN: We extracted data from all children born at ≥34 weeks of gestation within one ... Full text Link to item Cite

Racial Disparities in Lung Cancer Screening Among Veterans, 2013 to 2021.

Journal Article JAMA Netw Open · June 1, 2023 IMPORTANCE: Racial disparities in lung cancer screening (LCS) are often ascribed to barriers such as cost, insurance status, access to care, and transportation. Because these barriers are minimized within the Veterans Affairs system, there is a question of ... Full text Link to item Cite

Impact of Time to Fixation on Outcomes of Operative Treatment of Intra-articular Distal Radius Fractures.

Journal Article Hand (N Y) · May 26, 2023 BACKGROUND: The incidence of operative treatment of distal radius fractures (DRFs) has increased recently, but the optimal timing for surgical fixation remains unclear. We hypothesized that: (1) an increase in time to fixation of intra-articular DRFs would ... Full text Link to item Cite

A validated preoperative risk prediction tool for extended inpatient length of stay following anatomic or reverse total shoulder arthroplasty.

Journal Article Journal of shoulder and elbow surgery · May 2023 BackgroundRecent work has shown inpatient length of stay (LOS) following shoulder arthroplasty to hold the second strongest association with overall cost (after implant cost itself). In particular, a preoperative understanding for the patients at ... Full text Cite

A Validated Pre-operative Risk Prediction Tool for Extended Inpatient Length of Stay Following Primary Total Hip or Knee Arthroplasty.

Journal Article J Arthroplasty · May 2023 BACKGROUND: As value-based reimbursement models mature, understanding the potential trade-off between inpatient lengths of stay and complications or need for costly postacute care becomes more pressing. Understanding and predicting a patient's expected bas ... Full text Link to item Cite

Reflux Surgery in Lung Transplantation: A Multicenter Retrospective Study.

Journal Article Ann Thorac Surg · April 2023 BACKGROUND: Aspiration has been associated with graft dysfunction after lung transplantation, leading some to advocate for selective use of fundoplication despite minimal data supporting this practice. METHODS: We performed a multicenter retrospective stud ... Full text Link to item Cite

Association Between Preoperative Multidimensional Psychological Distress and Physical Function After Surgery for Sports-Related Injury.

Journal Article Orthop J Sports Med · April 2023 BACKGROUND: Psychological distress after orthopaedic surgery can lead to worse outcomes, including higher levels of disability and pain and lower quality of life. The 10-item Optimal Screening for Prediction for Referral and Outcome-Yellow Flag (OSPRO-YF) ... Full text Link to item Cite

Clinicopathologic Characteristics of Melanoma in Patients with Parkinson Disease.

Journal Article JID Innov · March 2023 Patients with Parkinson disease (PD) are at high risk for developing melanoma, although current literature lacks details on the associated clinicopathologic characteristics. Our retrospective case-control study aimed to guide skin cancer surveillance recom ... Full text Link to item Cite

Feeding, television, and sleep behaviors at one year of age in a diverse sample.

Journal Article Obes Pillars · March 2023 BACKGROUND: Healthy lifestyle behaviors that can prevent adverse health outcomes, including obesity, are formed in early childhood. This study describes feeding, television, and sleep behaviors among one-year-old infants and examines differences by sociode ... Full text Link to item Cite

Teledermatology May Benefit Marginalized Populations: National and Institutional Trends during the COVID-19 Pandemic.

Journal Article Dermatol Ther (Heidelb) · March 2023 INTRODUCTION: Limited data exist regarding demographic-specific teledermatology (TD) utilization during the coronavirus disease 2019 (COVID-19) pandemic. This study aimed to determine TD utilization trends during the pandemic. METHODS: A retrospective coho ... Full text Link to item Cite

Incidence and associated risk factors for systemic drug levels with inhaled aminoglycoside therapy.

Journal Article J Antimicrob Chemother · February 1, 2023 OBJECTIVES: To characterize the incidence of and risk factors for a detectable drug level (DDL) in patients that received inhaled aminoglycoside therapy. METHODS: This retrospective, single-centre study included adult patients who received at least one dos ... Full text Link to item Cite

Improved Outcomes in Severe Primary Graft Dysfunction After Heart Transplantation Following Donation After Circulatory Death Compared With Donation After Brain Death.

Journal Article J Card Fail · January 2023 BACKGROUND: Primary graft dysfunction (PGD), the leading cause of early mortality after heart transplantation, is more common following donation after circulatory death (DCD) than donation after brain death (DBD). We conducted a single-center, retrospectiv ... Full text Link to item Cite

Bending the Cardiovascular Event Curve by Evaluating the Potential Impact of Achieving Low-Density Lipoprotein Cholesterol Goal Across a Large Health System Among Secondary Prevention Patients.

Journal Article Am J Cardiol · January 1, 2023 Guidelines recommend aggressive low-density lipoprotein cholesterol (LDL-C) lowering in patients with atherosclerotic cardiovascular disease (ASCVD). However, the recommended threshold of LDL-C ≤70 mg/dL is often not achieved. We used data from the Duke Un ... Full text Link to item Cite

Safety of continuous left atrial phased-array intracardiac echocardiography during left atrial ablation for atrial fibrillation.

Journal Article Heart Rhythm O2 · December 2022 BACKGROUND: Pulmonary vein (PV) isolation using radiofrequency ablation (RFA) to treat atrial fibrillation (AF) requires delivery of contiguous transmural lesions at the PV antra while avoiding injury to the esophagus. Continuous 2-dimensional phased-array ... Full text Link to item Cite

A Randomized Controlled Trial of Mobile Health Intervention in Patients With Heart Failure and Diabetes.

Journal Article J Card Fail · November 2022 BACKGROUND: Mobile health (mHealth) platforms can affect health behaviors but have not been rigorously tested in randomized trials. OBJECTIVES: We sought to evaluate the effectiveness of a pragmatic mHealth intervention in patients with heart failure (HF) ... Full text Link to item Cite

Quality and Perceived Usefulness of Patient-Submitted Store-and-Forward Teledermatology Images.

Journal Article JAMA Dermatol · October 1, 2022 IMPORTANCE: Patient-submitted images vary considerably in quality and usefulness. Studies that characterize patient-submitted images in a real-life setting are lacking. OBJECTIVE: To evaluate the quality and perceived usefulness of patient-submitted images ... Full text Link to item Cite

Concordance of Preoperative 3D Templating in Stemless Anatomic Total Shoulder Arthroplasty.

Journal Article J Am Acad Orthop Surg · October 1, 2022 INTRODUCTION: Recent advances in preoperative 3D templating software allow surgeons to plan implant size and position for stemless total shoulder arthroplasty (TSA). Whether these preoperative plans accurately reflect intraoperative decisions is yet unknow ... Full text Link to item Cite

Monthly sulfadoxine/pyrimethamine-amodiaquine or dihydroartemisinin-piperaquine as malaria chemoprevention in young Kenyan children with sickle cell anemia: A randomized controlled trial.

Journal Article PLoS Med · October 2022 BACKGROUND: Children with sickle cell anemia (SCA) in areas of Africa with endemic malaria transmission are commonly prescribed malaria chemoprevention. Chemoprevention regimens vary between countries, and the comparative efficacy of prevention regimens is ... Full text Link to item Cite

High-dose, high-frequency ustekinumab therapy for patients with severe hidradenitis suppurativa.

Journal Article Br J Dermatol · September 2022 In this case series, ustekinumab therapy demonstrated efficacy in some patients with severe hidradenitis suppurativa previously treated with adalimumab and/or infliximab. Larger prospective studies are needed to evaluate ustekinumab as a treatment option f ... Full text Link to item Cite

Current Trends in Revision Hip Arthroplasty: Indications and Types of Components Revised.

Journal Article J Arthroplasty · July 2022 BACKGROUND: The materials and techniques for both primary and revision total hip arthroplasty (THA) have changed over time. This study evaluated if the indications for revision THA, rates of components utilized (femoral or acetabulum, both, or head/liner e ... Full text Link to item Cite

High Prevalence of Sleep Disturbance Is Associated with Femoroacetabular Impingement Syndrome.

Journal Article Arthrosc Sports Med Rehabil · April 2022 PURPOSE: The purpose of this study was to identify an association between Patient-Reported Outcomes Measurement Information System (PROMIS) sleep scores and other PROMIS domains in patients with femoroacetabular impingement syndrome (FAIS). METHODS: Patien ... Full text Open Access Link to item Cite

Appropriate patient selection for outpatient shoulder arthroplasty: a risk prediction tool.

Journal Article J Shoulder Elbow Surg · February 2022 BACKGROUND: The transition from inpatient to outpatient shoulder arthroplasty critically depends on appropriate patient selection, both to ensure safety and to counsel patients preoperatively regarding individualized risk. Cost and patient demand for same- ... Full text Link to item Cite

Treatment of Navicular Stress Fractures With an Algorithmic Approach.

Journal Article Foot Ankle Int · January 2022 BACKGROUND: Navicular stress fractures are becoming increasingly more common. There is no universal consensus on treatment. We provide an algorithm that we feel will be useful in determining treatment. METHODS: A retrospective study was performed on all pa ... Full text Link to item Cite

Shoe Allergens: A Retrospective Analysis of Cross-sectional Data From the North American Contact Dermatitis Group, 2005-2018.

Journal Article Dermatitis · January 2022 BACKGROUND: Shoe contact allergy can be difficult to diagnose and manage. OBJECTIVE: The aim of the study was to characterize demographics, clinical characteristics, patch test results, and occupational data for the North American Contact Dermatitis Group ... Full text Link to item Cite

Racial and Ethnic Differences in Maternal Social Support and Relationship to Mother-Infant Health Behaviors.

Journal Article Acad Pediatr · 2022 OBJECTIVE: To examine racial and ethnic differences in maternal social support in infancy and the relationship between social support and mother-infant health behaviors. METHODS: Secondary analysis of baseline data from a multisite obesity prevention trial ... Full text Link to item Cite

Prevalence of High Weight Status in Children Under 2 Years in NHANES and Statewide Electronic Health Records Data in North Carolina and South Carolina.

Journal Article Acad Pediatr · 2022 OBJECTIVES: We evaluated the prevalence of high weight status in children ages 0 to 24 months (m) using data from electronic health records (EHR) and NHANES. We also examined relationships between weight status during infancy and obesity at 24 months of ag ... Full text Link to item Cite

A Daily, Respiratory Therapist Assessment of Readiness to Liberate From Venovenous Extracorporeal Membrane Oxygenation in Patients With Acute Respiratory Distress Syndrome.

Journal Article Crit Care Explor · December 2021 UNLABELLED: We assessed the effect of implementing a protocol-directed strategy to determine when patients can be liberated from venovenous extracorporeal membrane oxygenation on extracorporeal membrane oxygenation duration, time to initiation of first swe ... Full text Link to item Cite

Improvement in Health-Related Quality of Life After Total Ankle Arthroplasty Compares Well With Other Successful Orthopaedic and Nonorthopaedic Procedures.

Journal Article Foot Ankle Spec · October 2021 Background. Ankle arthritis is a major cause of disability. Orthopaedic literature suggests improvement in health-related quality of life (HRQOL) after total ankle arthroplasty (TAA). This has not been compared with improvements observed in successful orth ... Full text Link to item Cite

Initial displacement of the intra-articular surface after articular fracture correlates with PTA in C57BL/6 mice but not "superhealer" MRL/MpJ mice.

Journal Article J Orthop Res · September 2021 Posttraumatic arthritis (PTA) occurs commonly after articular fracture and may arise, in part, from joint surface incongruity after injury. MRL/MpJ (MRL) "super-healer" mice are protected from PTA compared to C57BL/6 (B6) mice following articular fracture. ... Full text Open Access Link to item Cite

Early Identification of Patients at Risk for Incident Heart Failure With Preserved Ejection Fraction: Novel Approach to Echocardiographic Trends.

Journal Article J Card Fail · September 2021 BACKGROUND: Heart failure with preserved ejection fraction (HFpEF) continues to increase in prevalence with a 50% mortality rate within 3 years of diagnosis, but lacking effective evidence-based therapies. Specific echocardiographic markers are not typical ... Full text Link to item Cite

Retrospective Analysis of Quality Control Data Using Pooled Blood to Compare Agreement within Two Models of Blood Gas Analyzers.

Journal Article J Appl Lab Med · September 1, 2021 BACKGROUND: Two previous reports from the same group concluded that the analytical reliability of Instrumentation Laboratory GEM4000 analyzers (GEM4K) deteriorated during a 24-hour period, based on results between samples from the same patient but collecte ... Full text Link to item Cite

Atopic dermatitis is associated with hidradenitis suppurativa diagnosis: A single institution retrospective cohort study.

Journal Article JAAD Int · September 2021 BACKGROUND: Hidradenitis suppurativa (HS) and atopic dermatitis (AD) are both chronic inflammatory skin diseases. An association between these 2 conditions can have important potential implications for elucidating pathogenesis, disease course, and treatmen ... Full text Link to item Cite

Heterotopic ossification formation after fractures about the elbow.

Journal Article Eur J Orthop Surg Traumatol · August 2021 INTRODUCTION: Heterotopic ossification (HO) is a well-known sequela after an elbow injury and is widely studied given the associated morbidity. The anatomic location of HO development for specific elbow injuries has not been reported. The purpose of this s ... Full text Link to item Cite

Tracheostomy for COVID-19 Respiratory Failure: Multidisciplinary, Multicenter Data on Timing, Technique, and Outcomes.

Journal Article Ann Surg · August 1, 2021 OBJECTIVE: The aim of this study was to assess the outcomes of tracheostomy in patients with COVID-19 respiratory failure. SUMMARY BACKGROUND DATA: Tracheostomy has an essential role in managing COVID-19 patients with respiratory failure who require prolon ... Full text Open Access Link to item Cite

Establishing Age- and Sex-Specific Norms for Pediatric Return-to-Sports Physical Performance Testing.

Journal Article Orthop J Sports Med · August 2021 BACKGROUND: Graft tears and contralateral anterior cruciate ligament (ACL) tears are common in pediatric athletes after ACL reconstruction. Use of objective return-to-sports (RTS) criteria, in particular physical performance tests (PPTs), is believed to re ... Full text Link to item Cite

Low utilisation of bronchoscopy to assess COVID-19 respiratory infection: a multicenter experience.

Journal Article BMJ Open Respir Res · July 2021 OBJECTIVE: For the diagnosis of COVID-19, the yield of nasopharyngeal (NP) swabs is unclear, and bronchoalveolar lavage (BAL) is obtained to confirm the diagnosis. We assessed the utilisation of bronchoscopy for COVID-19 diagnosis in a multicenter study an ... Full text Link to item Cite

Multisite Quality Improvement Study of a Patient-Pathologist Consultation Program.

Journal Article Am J Clin Pathol · May 18, 2021 OBJECTIVES: The aim of this multisite quality improvement study was to evaluate patients' experiences with the patient-centered pathology (PCP) consultation program and to determine whether PCP enhanced their care experience. METHODS: Patients were invited ... Full text Link to item Cite

Use of hospital resources in the care of patients with intermediate risk pulmonary embolism.

Journal Article Eur Heart J Acute Cardiovasc Care · May 11, 2021 BACKGROUND: Risk stratification and management of hemodynamically stable pulmonary embolism remains challenging. Professional societies have published stratification schemes, but little is known about the management of patients with intermediate risk pulmo ... Full text Link to item Cite

Resilience and pain catastrophizing among patients with total knee arthroplasty: a cohort study to examine psychological constructs as predictors of post-operative outcomes.

Journal Article Health Qual Life Outcomes · May 1, 2021 BACKGROUND: Patients' psychological health may influence recovery and functional outcomes after total knee arthroplasty (TKA). Pain catastrophizing, known to be associated with poor function following TKA, encompasses rumination, magnification, and helples ... Full text Link to item Cite

Contact dermatitis associated with preservatives: Retrospective analysis of North American Contact Dermatitis Group data, 1994 through 2016.

Journal Article J Am Acad Dermatol · April 2021 BACKGROUND: Preservatives are often necessary components of commercial products. Large-scale North American studies on preservative allergy are limited. OBJECTIVE: To evaluate demographics, positive patch test reactions (PPTRs), clinical relevance, and tre ... Full text Link to item Cite

Splanchnic Nerve Block Mediated Changes in Stressed Blood Volume in Heart Failure.

Journal Article JACC Heart Fail · April 2021 OBJECTIVES: The authors estimated changes of stressed blood volume (SBV) induced by splanchnic nerve block (SNB) in patients with either decompensated or ambulatory heart failure with reduced ejection fraction (HFrEF). BACKGROUND: The splanchnic vascular c ... Full text Link to item Cite

Reduced MFAP5 expression in stroma of gallbladder adenocarcinoma and its potential diagnostic utility.

Journal Article Virchows Arch · March 2021 The diagnosis of invasive adenocarcinoma of the gallbladder can sometimes be challenging. The presence of true desmoplastic reaction facilitates the diagnosis of invasion. However, desmoplasia-like changes can be observed in benign gallbladder conditions, ... Full text Link to item Cite

The Critical Portions of Carpal Tunnel Surgery: A Comparison Between Opinions of Surgeons and the General Public.

Journal Article J Hand Surg Am · March 2021 PURPOSE: Attending surgeons must participate in critical and key portions of procedures and otherwise be immediately available. However, surgeon-defined standards of the critical and key portions of surgery have been questioned, potentially affecting train ... Full text Link to item Cite

Cardiac computed tomography improves the identification of cardiomechanical complications among patients with suspected left ventricular assist device malfunction.

Journal Article J Cardiovasc Comput Tomogr · 2021 BACKGROUND: Left ventricular assist devices (LVAD) are increasingly used for durable mechanical circulatory support in advanced heart failure. While LVAD therapy provides substantial improvement in mortality and quality of life, long-term therapy confers i ... Full text Link to item Cite

Fragrance- and Botanical-Related Allergy and Associated Concomitant Reactions: A Retrospective Analysis of the North American Contact Dermatitis Group Data 2007-2016.

Journal Article Dermatitis · January 2021 IMPORTANCE: When fragrance- and botanical-related (F/BR) allergy is identified, concomitant reaction (CR) frequencies can help direct avoidance recommendations. OBJECTIVE: This study aimed to determine the CR rates for F/BR allergens. DESIGN: A retrospecti ... Full text Link to item Cite

Healthy Pediatric Athletes Have Significant Baseline Limb Asymmetries on Common Return-to-Sport Physical Performance Tests.

Journal Article Orthop J Sports Med · January 2021 BACKGROUND: Return to sport (RTS) after anterior cruciate ligament (ACL) reconstruction in children is associated with a much higher risk (∼30%) of subsequent ACL injury than in adults. Most RTS testing protocols use a limb symmetry index (LSI) ≥90% on phy ... Full text Link to item Cite

Staying ahead of the curve: the use of spinopelvic parameters to predict curve progression and bracing success in adolescent idiopathic scoliosis.

Journal Article Spine Deform · December 2020 STUDY DESIGN: Retrospective cohort study. OBJECTIVES: To investigate radiographic sagittal and spinopelvic parameters of patients with adolescent idiopathic scoliosis (AIS) treated with bracing and assess differences among those treated successfully and un ... Full text Link to item Cite

Use of hospital resources in the care of patients with intermediate risk pulmonary embolism.

Journal Article Eur Heart J Acute Cardiovasc Care · November 27, 2020 BACKGROUND: Risk stratification and management of hemodynamically stable pulmonary embolism remains challenging. Professional societies have published stratification schemes, but little is known about the management of patients with intermediate risk pulmo ... Full text Link to item Cite

Splanchnic Nerve Block for Chronic Heart Failure.

Journal Article JACC Heart Fail · September 2020 OBJECTIVES: We hypothesized that splanchnic nerve blockade (SNB) would attenuate increased exercise-induced cardiac filling pressures in patients with chronic HF. BACKGROUND: Chronic heart failure (HF) is characterized by limited exercise capacity driven i ... Full text Link to item Cite

Catheter ablation of atrial fibrillation in patients with diabetes mellitus.

Journal Article Heart Rhythm O2 · August 2020 BACKGROUND: Diabetes mellitus (DM) is an independent risk factor for atrial fibrillation (AF). Few studies have compared clinical outcomes after catheter ablation between patients with and those without DM. OBJECTIVE: The purpose of this study was to compa ... Full text Open Access Link to item Cite

Patient Characteristics of Possible Responders and Nonresponders to Total Ankle Arthroplasty.

Journal Article Foot Ankle Int · August 2020 BACKGROUND: Characteristics of responders, or those who achieve a clinical improvement above the level of a minimal clinically important difference, have not been defined for total ankle arthroplasty (TAA). The purpose of this study was to determine patien ... Full text Link to item Cite

The Role of Radiotherapy for Chordoma Patients Managed With Surgery: Analysis of the National Cancer Database.

Journal Article Spine (Phila Pa 1976) · June 15, 2020 STUDY DESIGN: Retrospective review. OBJECTIVE: To determine if adjuvant radiation therapy (RT) improves overall survival (OS) following surgical resection of chordomas. SUMMARY OF BACKGROUND DATA: The role of RT for the treatment of chordomas remains incom ... Full text Link to item Cite

Meta-analysis of number needed to treat for diagnosis of melanoma by clinical setting.

Journal Article J Am Acad Dermatol · May 2020 OBJECTIVE: To provide a formal statistical comparison of the efficacy of melanoma detection among different clinical settings. METHODS: A systematic review and meta-analysis of all relevant observational studies on number needed to treat (NNT) in relation ... Full text Link to item Cite

Heterogeneous Outcomes of Heart Failure with Better Ejection Fraction.

Journal Article J Cardiovasc Transl Res · April 2020 We evaluated the heterogeneity of outcomes among heart failure patients with ventricular recovery. The BEST trial studied patients with left ventricular ejection fraction (LVEF) ≤ 35%. Serial LVEF assessment was performed at baseline, 3 months, and 12 mont ... Full text Link to item Cite

Malignant Diffuse Mesothelioma in Women: A Study of 354 Cases.

Journal Article Am J Surg Pathol · March 2020 We reviewed 354 cases of malignant diffuse mesothelioma (MM) in women from a database of 2858 histologically confirmed MM cases. There was a pleural predominance with 78% pleural MM and 22% peritoneal MM. The pleural tumors consisted of 72% epithelioid, 19 ... Full text Link to item Cite

Phenotypic characteristics and asthma severity in an East African cohort of adults and adolescents with asthma: findings from the African severe asthma project.

Journal Article BMJ Open Respir Res · February 2020 RATIONALE: The relationship between clinical and biomarker characteristics of asthma and its severity in Africa is not well known. METHODS: Using the Expert Panel Report 3, we assessed for asthma severity and its relationship with key phenotypic characteri ... Full text Link to item Cite

Effects of Virtual Exercise Rehabilitation In-Home Therapy Compared with Traditional Care After Total Knee Arthroplasty: VERITAS, a Randomized Controlled Trial.

Journal Article J Bone Joint Surg Am · January 15, 2020 BACKGROUND: Financial burden for patients, providers, and payers can reduce access to physical therapy (PT) after total knee arthroplasty (TKA). The purpose of the present study was to examine the effect of a virtual PT program on health-care costs and cli ... Full text Link to item Cite

Validated model of platelet slip at stenosis and device surfaces.

Journal Article Platelets · 2020 Platelets are central to thrombosis. However, it is unknown whether platelets slip at vascular or device surfaces. The presence of platelet slip at a surface would interrupt physical contact between the platelet and that surface, and therefore diminish adh ... Full text Link to item Cite

Patch Test Practice Patterns of Members of the American Contact Dermatitis Society.

Journal Article Dermatitis · 2020 BACKGROUND: Patch testing is the criterion standard for diagnosis and management of allergic contact dermatitis. Limitations on the number of allergens tested can negatively impact patient care. OBJECTIVE: This study reports clinical practice patterns of A ... Full text Link to item Cite

A comparison of knowledge acquisition and perceived efficacy of a traditional vs flipped classroom-based dermatology residency curriculum.

Journal Article Cutis · January 2020 Flipped and traditional classroom models were compared in the Duke University Medical Center (Durham, North Carolina) dermatology residency program for the 2014-2015 academic year. The residents participated in 12 lectures-6 traditional and 6 flipped-that ... Link to item Cite

Duration of Dermatitis Before Patch Test Appointment Is Associated With Distance to Clinic and County Poverty Rate.

Journal Article Dermatitis · 2020 BACKGROUND: Contact dermatitis is a common disease that is associated with impaired quality of life. OBJECTIVE: We examined the effect of travel distance and other socioeconomic factors on duration of dermatitis before presentation at the Duke Contact Derm ... Full text Link to item Cite

EBUS-FNA cytologic-histologic correlation of PD-L1 immunohistochemistry in non-small cell lung cancer.

Journal Article J Am Soc Cytopathol · 2020 INTRODUCTION: Immune checkpoint pathway markers induce immune tolerance to non-small cell lung cancer (NSCLC). Therapeutic antibodies targeting the programmed cell death 1 (PD-1)/programmed cell death ligand 1 (PD-L1) pathway have demonstrated efficacy in ... Full text Link to item Cite

Sex influences on ventricular repolarization duration in normal subjects and in type 1, 2 and 3 long QT syndrome patients: Different effect in acquired and congenital type 2 LQTS.

Journal Article J Electrocardiol · 2020 AIM: To evaluate the interaction between sex and rate corrected QT interval (QTc) duration in normal subjects after drug-induced QT prolongation and in LQTS patients. METHODS: Semi-automated measurements were performed on 875 digital ECGs (200 normal subje ... Full text Link to item Cite

Predicting atrial fibrillation recurrence after ablation in patients with heart failure: Validity of the APPLE and CAAP-AF risk scoring systems.

Journal Article Pacing Clin Electrophysiol · November 2019 BACKGROUND: Compared with medical therapy, catheter ablation of atrial fibrillation (AF) in patients with heart failure (HF) improves cardiovascular outcomes. Risk scores (CAAP-AF and APPLE) have been developed to predict the likelihood of AF recurrence af ... Full text Open Access Link to item Cite

Identification, diagnosis, treatment, and in-hospital outcomes of acute pulmonary embolism: Results from a single integrated health system.

Journal Article Am Heart J · October 2019 BACKGROUND: Although the high-risk acute pulmonary embolism (PE) population has been described, little is known about the contemporary inpatient experience and practice patterns of the PE population as a whole. METHODS: All patients with a diagnosis of acu ... Full text Link to item Cite

Tranexamic acid or epsilon-aminocaproic acid in total joint arthroplasty? A randomized controlled trial.

Journal Article Bone Joint J · September 2019 AIMS: Antifibrinolytic agents, including tranexamic acid (TXA) and epsilon-aminocaproic acid (EACA), have been shown to be safe and effective for decreasing perioperative blood loss and transfusion following total hip arthroplasty (THA) and total knee arth ... Full text Link to item Cite

Clinical Impact of Routine Complete Blood Counts Following Total Knee Arthroplasty.

Journal Article J Arthroplasty · July 2019 BACKGROUND: Routine laboratory studies are generally obtained following total knee arthroplasty (TKA), and often continued daily until discharge. This study aims to investigate the utility and cost-effectiveness of complete blood count (CBC) tests followin ... Full text Link to item Cite

Interrater Reliability of Clinical Grading Measures for Cutaneous Chronic Graft-vs-Host Disease.

Journal Article JAMA Dermatol · July 1, 2019 IMPORTANCE: Cutaneous chronic graft-vs-host disease (cGVHD) is common after allogeneic hematopoietic stem cell transplant and is often associated with poor patient outcomes. A reliable and practical method for assessing disease severity and response to the ... Full text Link to item Cite

Small Social Incentives Did Not Improve the Survey Response Rate of Patients Who Underwent Orthopaedic Surgery: A Randomized Trial.

Journal Article Clin Orthop Relat Res · July 2019 BACKGROUND: The generalizability of data derived from patient-reported outcome measures (PROMs) depends largely on the proportion of the relevant population that completes PROM surveys. However, PROM survey responses remain low, despite efforts to increase ... Full text Link to item Cite

Continuous adductor canal blockade facilitates increased home discharge and decreased opioid consumption after total knee arthroplasty.

Journal Article Knee · June 2019 BACKGROUND: There is a growing interest in avoiding discharging patients to rehab to maximize outcome and minimize complications after total knee arthroplasty (TKA). In addition, use of postoperative pain pathways that minimize opioid use is critical amids ... Full text Link to item Cite

Frequency of Contact Allergy to Implanted Cardiac Devices.

Journal Article JAMA Dermatol · June 1, 2019 This retrospective study evaluated 11 patients who underwent cardiac implant patch testing to assess the frequency of allergic reaction. ... Full text Link to item Cite

Comparing Standard Versus Extended Culture Duration in Acute Hip and Knee Periprosthetic Joint Infection.

Journal Article J Am Acad Orthop Surg · May 1, 2019 INTRODUCTION: Periprosthetic joint infection (PJI) is a devastating complication of hip and knee arthroplasties. Surgical cultures are essential for the diagnosis and treatment of PJI. Yet, the ideal culture duration remains unclear. This study compares cu ... Full text Link to item Cite

Utilizing mobile technologies to improve physical activity and medication adherence in patients with heart failure and diabetes mellitus: Rationale and design of the TARGET-HF-DM Trial.

Journal Article Am Heart J · May 2019 Heart failure (HF) and diabetes mellitus (DM) are major public health issues that place significant burden on patients and health care systems. Patients with both HF and DM are at higher risk of adverse cardiovascular and HF outcomes than those with either ... Full text Link to item Cite

The effect of obesity on fatty infiltration of the rotator cuff musculature in patients without rotator cuff tears.

Journal Article Shoulder Elbow · May 2019 BACKGROUND: The modified Goutallier classification system describes the fatty infiltration of rotator cuff musculature (RCM) seen on magnetic resonance imaging (MRI) to assist with surgical decision-making for patients with rotator cuff tears (RCT). We des ... Full text Link to item Cite

Flow cytometry immunophenotyping of vitreous specimens does not contribute to diagnosis of lymphoma without supporting morphologic features.

Journal Article Diagn Cytopathol · April 2019 BACKGROUND: Diagnostic vitrectomy with flow cytometry immunophenotyping (FCI) is being increasingly used as part of screening for diagnostically challenging cases. We aim to evaluate the utility of combined cytopathology and FCI in diagnostic pars plana vi ... Full text Link to item Cite

Hindfoot Arthrodesis Screw Position and Trajectory Effect on Talus Subsidence When Performed With Total Ankle Arthroplasty.

Journal Article Foot Ankle Int · March 2019 BACKGROUND:: Total ankle arthroplasty (TAA) is increasingly being recognized as an effective surgical option for end-stage ankle arthritis. Associated hindfoot arthrodesis procedures are at times needed to correct malalignment or to address adjacent joint ... Full text Link to item Cite

Relationship Between PROMIS Computer Adaptive Tests and Legacy Hip Measures Among Patients Presenting to a Tertiary Care Hip Preservation Center.

Journal Article Am J Sports Med · March 2019 BACKGROUND: Legacy hip outcome measures may be burdensome to patients and sometimes yield floor or ceiling effects. Patient-Reported Outcomes Measurement Information System (PROMIS) computer adaptive tests (CATs) allow for low-burden data capture and limit ... Full text Link to item Cite

Preoperative Hemoglobin Predicts Postoperative Transfusion Despite Antifibrinolytics During Total Knee Arthroplasty.

Journal Article Orthopedics · March 1, 2019 Current antifibrinolytics have decreased perioperative blood loss; however, some patients still require transfusions postoperatively. The authors sought to determine the risk factors associated with postoperative transfusions and to establish a "cutoff" pr ... Full text Link to item Cite

How Arthroscope Orientation Affects Performance: Arthroscopy in the Perspective of the Viewer and Arthroscopy Opposite of the Viewer.

Journal Article J Bone Joint Surg Am · February 20, 2019 BACKGROUND: Elements of competency-based training are being incorporated into surgical training. The primary objective of this study was to determine how the orientation of the arthroscope and the instruments relative to the standing position of the surgeo ... Full text Link to item Cite

Dimensions of elongated mineral particles: a study of more than 570 fibers from more than 90 cases with implications for pathogenicity and classification as asbestiform vs. cleavage fragments.

Journal Article Ultrastruct Pathol · 2019 Asbestos is well-recognized as the cause of a variety of disorders of the respiratory tract, including neoplastic as well as non-neoplastic conditions. Fiber dimensions and biopersistence are important determinants of the pathologic response, and analytica ... Full text Link to item Cite

Immediate Physical Therapy following Total Joint Arthroplasty: Barriers and Impact on Short-Term Outcomes.

Journal Article Adv Orthop · 2019 BACKGROUND: Recent evidence suggests benefit to receiving physical therapy (PT) the same day as total joint arthroplasty (TJA), but relatively little is known about barriers to providing PT in this constrained time period. We address the following question ... Full text Open Access Link to item Cite

Research implications of the FDA ECG warehouse and related resources.

Journal Article J Electrocardiol · 2019 The electrocardiogram is often used as an efficacy endpoint for comparing new drugs or as an indicator for cardiovascular safety in both studies of arrhythmic and non-arrhythmic novel drugs. The FDA ECG Warehouse data are owned by the submitting entities, ... Full text Link to item Cite

Impact of lumbar arthrodesis on outcomes after elective total hip arthroplasty

Journal Article Seminars in Arthroplasty JSES · December 1, 2018 Background: Acetabular component malpositioning has been associated with major complications including dislocation, edge-loading, stripe wear and squeaking. Anteversion is determined by pelvic orientation; flexion of the pelvis increases and extension decr ... Full text Cite

Bursts of reperfusion arrhythmias occur independently of area at risk size and are the first marker of reperfusion injury.

Journal Article Int J Cardiol · November 15, 2018 BACKGROUND: The presence of reperfusion ventricular arrhythmias (VA) has been shown to correlate with larger infarct size (IS). However it is unclear whether the initial area at risk (AAR), also a determining factor for IS, is responsible for this correlat ... Full text Link to item Cite

Albumin Versus American Society of Anesthesiologists Score: Which Is More Predictive of Complications Following Total Joint Arthroplasty?

Journal Article Orthopedics · November 1, 2018 Malnutrition is not uncommon in arthroplasty patients, and hypoalbuminemia has been shown to be predictive of postoperative complications. The authors sought to compare albumin concentration with a global assessment of physical health, the American Society ... Full text Link to item Cite

When Should Complete Blood Count Tests Be Performed in Primary Total Hip Arthroplasty Patients?

Journal Article J Arthroplasty · October 2018 BACKGROUND: Routine laboratory studies are often obtained following total hip arthroplasty (THA). Moreover, laboratory studies are often continued daily until the patient is discharged regardless of medical management. The purpose of this study was to inve ... Full text Link to item Cite

Dislocation rate increases with bariatric surgery before total hip arthroplasty.

Journal Article Hip Int · September 2018 INTRODUCTION: Annually in the USA, 113,000 patients with refractory obesity undergo bariatric surgery (BS), and a subset does so in order to lower body mass index to become a more desirable total hip arthroplasty (THA) candidate. This study aims to evaluat ... Full text Link to item Cite

Preoperative Patient Profile in Total Hip and Knee Arthroplasty: Predictive of Increased Medicare Payments in a Bundled Payment Model.

Journal Article J Arthroplasty · September 2018 BACKGROUND: The shift toward value-based bundled payment models in total joint arthroplasty highlights the need for identification of modifiable risk factors for increased spending as well as opportunities to mitigate perioperative treatment of chronic dis ... Full text Link to item Cite

The Utility of Basic Metabolic Panel Tests After Total Joint Arthroplasty.

Journal Article J Arthroplasty · September 2018 INTRODUCTION: Routine laboratory studies are often obtained daily after total joint arthroplasty (TJA) regardless of medical management. The purpose of this study was to investigate the utility of routine basic metabolic panel (BMP) tests after TJA. Furthe ... Full text Link to item Cite

Splanchnic Nerve Block for Acute Heart Failure.

Journal Article Circulation · August 28, 2018 Full text Link to item Cite

Reply.

Journal Article J Allergy Clin Immunol · August 2018 Full text Link to item Cite

Assessing the impact of a remote digital coaching engagement program on patient-reported outcomes in asthma.

Journal Article J Asthma · July 2018 BACKGROUND: Low adherence and poor outcomes provide opportunity for digital coaching to engage patients with uncontrolled asthma in their care to improve outcomes. OBJECTIVE(S): To examine the impact of a remote digital coaching program on asthma control a ... Full text Link to item Cite

Trends in Opioid Utilization Before and After Total Knee Arthroplasty.

Journal Article J Arthroplasty · July 2018 BACKGROUND: Opioids are a mainstay in perioperative pain management among patients undergoing total knee arthroplasty (TKA). However, patterns in opioid use before and after TKA have not been well-studied. The objectives of this study are to characterize p ... Full text Link to item Cite

Comparison of automated interval measurements by widely used algorithms in digital electrocardiographs.

Journal Article Am Heart J · June 2018 BACKGROUND: Automated measurements of electrocardiographic (ECG) intervals by current-generation digital electrocardiographs are critical to computer-based ECG diagnostic statements, to serial comparison of ECGs, and to epidemiological studies of ECG findi ... Full text Link to item Cite

Catheter ablation of atrial fibrillation in patients with heart failure and preserved ejection fraction.

Journal Article Heart Rhythm · May 2018 BACKGROUND: Few studies have examined outcomes of catheter ablation for atrial fibrillation (AF) in patients with heart failure (HF) with preserved ejection fraction (HFpEF). OBJECTIVE: The purpose of this study was to compare outcomes of AF ablation in pa ... Full text Link to item Cite

Dual Diagnosis and Total Hip Arthroplasty.

Journal Article Orthopedics · May 1, 2018 The co-occurrence of a mental illness and a substance abuse disorder (SUD) is common and has been referred to as a "dual diagnosis" (DD). Although studies have independently investigated mental illness alone and SUD alone, few have examined the effects of ... Full text Link to item Cite

Race is an independent predictor of survival in patients with soft tissue sarcoma of the extremities.

Journal Article BMC Cancer · April 27, 2018 BACKGROUND: In the United States, race and socioeconomic status are well known predictors of adverse outcomes in several different cancers. Existing evidence suggests that race and socioeconomic status may impact survival in soft tissue sarcoma (STS). We i ... Full text Link to item Cite

Reperfusion ventricular arrhythmia bursts identify larger infarct size in spite of optimal epicardial and microvascular reperfusion using cardiac magnetic resonance imaging.

Journal Article Eur Heart J Acute Cardiovasc Care · April 2018 AIMS: Ventricular arrhythmia (VA) bursts following recanalisation in acute ST-elevation myocardial infarction (STEMI) are related to larger infarct size (IS). Inadequate microvascular reperfusion, as determined by microvascular obstruction (MVO) using card ... Full text Link to item Cite

Inpatient Consults and Complications During Primary Total Joint Arthroplasty in a Bundled Care Model.

Journal Article J Arthroplasty · April 2018 BACKGROUND: The Centers for Medicare and Medicaid Services (CMS) are implementing changes in hospital reimbursement models for total joint arthroplasty (TJA), moving to value-based bundled payments from the fee-for-service model. The purpose of this study ... Full text Link to item Cite

(Meth)acrylate allergy: frequently missed?

Journal Article Br J Dermatol · April 2018 Full text Link to item Cite

Obesity's effect on asthma extends to diagnostic criteria.

Journal Article J Allergy Clin Immunol · March 2018 BACKGROUND: The use of inflammatory biomarkers to delineate the type of lung inflammation present in asthmatic subjects is increasingly common. However, the effect of obesity on these markers is unknown. OBJECTIVES: We aimed to determine the effect of obes ... Full text Link to item Cite

Obese asthmatic patients have decreased surfactant protein A levels: Mechanisms and implications.

Journal Article J Allergy Clin Immunol · March 2018 BACKGROUND: Eosinophils are prominent in some patients with asthma and are increased in the submucosa in a subgroup of obese patients with asthma (OAs). Surfactant protein A (SP-A) modulates host responses to infectious and environmental insults. OBJECTIVE ... Full text Open Access Link to item Cite

Intrawound Vancomycin Powder in Primary Total Hip Arthroplasty Increases Rate of Sterile Wound Complications.

Journal Article Hip Pelvis · March 2018 PURPOSE: Total hip arthroplasty (THA) is a successful surgery for the treatment of hip osteoarthritis; however, the risk of a post-operative prosthetic joint infection (PJI) remains at 1% to 2%. The purpose of this study was to investigate the safety profi ... Full text Link to item Cite

Epsilon Aminocaproic Acid to Reduce Blood Loss and Transfusion After Total Hip and Total Knee Arthroplasty.

Journal Article J Arthroplasty · January 2018 BACKGROUND: Total hip and knee arthroplasty (THA and TKA) are associated with significant blood loss and some patients require postoperative blood transfusion. While tranexamic acid has been studied extensively among this population, we tested the hypothes ... Full text Link to item Cite

Pre- and postoperative anemia, acute kidney injury, and mortality after coronary artery bypass grafting surgery: a retrospective observational study.

Journal Article Can J Anaesth · January 2018 BACKGROUND: Preoperative and postoperative anemia have been identified individually as potential risk factors for postoperative complications after coronary artery bypass grafting (CABG) surgery. Their interrelationship with acute kidney injury (AKI) and l ... Full text Link to item Cite

Midterm Results of the Salto Talaris Total Ankle Arthroplasty.

Journal Article Foot Ankle Int · November 2017 BACKGROUND: The Salto Talaris total ankle replacement is a modern fixed-bearing implant used to treat symptomatic ankle arthritis with the goals of providing pain relief, restoring mechanical alignment, and allowing motion of the ankle joint. The goal of t ... Full text Link to item Cite

What Should Define Preoperative Anemia in Primary THA?

Journal Article Clin Orthop Relat Res · November 2017 BACKGROUND: The use of tranexamic acid (TXA) in THA decreases the risk of transfusion after surgery. However, nearly 10% of patients still undergo a transfusion, which has been independently associated with an increased risk of complications. Preoperative ... Full text Link to item Cite

What Factors Drive Inpatient Satisfaction After Knee Arthroplasty?

Journal Article J Arthroplasty · June 2017 BACKGROUND: The Hospital Consumer Assessment of Healthcare Providers and Systems (HCAHPS) survey, developed by the Centers for Medicare & Medicaid Services, is directly tied to hospital reimbursement. The purpose of this study is to analyze survey response ... Full text Link to item Cite

The Association of Recreational and Competitive Running With Hip and Knee Osteoarthritis: A Systematic Review and Meta-analysis.

Journal Article J Orthop Sports Phys Ther · June 2017 Study Design Systematic review and meta-analysis. Background Running is a healthy and popular activity worldwide, but data regarding its association with osteoarthritis (OA) are conflicting. Objectives To evaluate the association of hip and knee OA with ru ... Full text Link to item Cite

Operative Wound Complications Following Total Ankle Arthroplasty.

Journal Article Foot Ankle Int · April 2017 BACKGROUND: Wound complications following total ankle replacement (TAR) potentially lead to devastating consequences. The aim of this study was to compare the operative and demographic differences in patients with and without major wound problems which req ... Full text Link to item Cite

Emphasizing Bloom's Affective Domain to Reduce Pharmacy Students' Stigmatizing Attitudes.

Journal Article Am J Pharm Educ · March 25, 2017 Objective. To create a learning environment using Bloom's affective domain as a framework that would reduce third-year pharmacy students' stigmatizing attitudes toward patients with mental illness. Design. Prior to the start of the module, students were as ... Full text Link to item Cite

Complications of total hip arthroplasty following solid organ transplantation.

Journal Article J Orthop Sci · March 2017 PURPOSE: Solid organ transplants (SOT) continue to increase with recipients living longer than ever before. The lifelong immunosuppression in these patients also may place them at increased risk for postoperative complications. The efficacy of total hip ar ... Full text Link to item Cite

The Effect of Fixation Technique on Continuous Interscalene Nerve Block Catheter Success: A Randomized, Double-Blind Trial.

Journal Article Anesth Analg · March 2017 BACKGROUND: Continuous peripheral nerve blocks offer advantages over single-injection blocks, including extended analgesia and reduction in opioid consumption. These benefits require that the perineural catheter remain intact for the duration of the planne ... Full text Link to item Cite

Contact Allergy to Hydroperoxides of Linalool and D-Limonene in a US Population.

Journal Article Dermatitis · 2017 BACKGROUND: Linalool and D-limonene are common fragrance ingredients that readily oxidize on exposure to air. The resulting hydroperoxides of linalool and D-limonene have been shown to have high frequencies of positive patch test reactions in several Europ ... Full text Link to item Cite

What is the best ST-segment recovery parameter to predict clinical outcome and myocardial infarct size? Amplitude, speed, and completeness of ST-segment recovery after primary percutaneous coronary intervention for ST-segment elevation myocardial infarction.

Journal Article J Electrocardiol · 2017 AIMS: ST-segment recovery (STR) is a strong mechanistic correlate of infarct size (IS) and outcome in ST-segment elevation myocardial infarction (STEMI). Characterizing measures of speed, amplitude, and completeness of STR may extend the use of this noninv ... Full text Link to item Cite

Psychiatric disorders increase complication rate after primary total knee arthroplasty.

Journal Article Knee · October 2016 BACKGROUND: Psychiatric disease is difficult to screen preoperatively and the incidence of mental health disorders in patients undergoing total knee arthroplasty (TKA) may be underappreciated. The purpose of this study is to evaluate the perioperative comp ... Full text Link to item Cite

Association of Cigarette Use and Complication Rates and Outcomes Following Total Ankle Arthroplasty.

Journal Article Foot Ankle Int · October 2016 BACKGROUND: Tobacco use is a known risk factor for increased perioperative complications and having worse functional outcomes in many orthopedic procedures. To date, no study has elucidated the effect of cigarette smoking on complications or functional out ... Full text Link to item Cite

Lingering Risk: Bariatric Surgery Before Total Knee Arthroplasty.

Journal Article J Arthroplasty · September 2016 BACKGROUND: Obesity continues to increase in the United States with an estimated 35% obesity and 8% bariatric (body mass index >40) rate in adults. Bariatric patients seek advice from arthroplasty surgeons regarding the temporality of bariatric surgery (BS ... Full text Link to item Cite

Increased leptin levels correlate with thyroid autoantibodies in nonobese males.

Journal Article Clin Endocrinol (Oxf) · July 2016 OBJECTIVE: Leptin is an adipokine that regulates body weight and appetite. It is also an inflammatory cytokine that influences immune reactivity and autoimmunity. Leptin levels are increased in obesity and are higher in women than in men. We aimed to deter ... Full text Open Access Link to item Cite

The Cardiac Safety Research Consortium enters its second decade: An invitation to participate.

Journal Article Am Heart J · July 2016 The Cardiac Safety Research Consortium (CSRC), a transparent, public-private partnership established in 2005 as a Critical Path Program and formalized in 2006 under a Memorandum of Understanding between the United States Food and Drug Administration and Du ... Full text Link to item Cite

Percent Body Fat Is More Predictive of Function After Total Joint Arthroplasty Than Body Mass Index.

Journal Article J Bone Joint Surg Am · May 18, 2016 BACKGROUND: Obesity has an important impact on the future of total joint arthroplasty; however, the definition and influence of obesity on surgical risks and outcomes remain controversial. Our hypothesis was that percent body fat was better than body mass ... Full text Link to item Cite

In Reply.

Journal Article Anesthesiology · April 2016 Full text Link to item Cite

Maximum likelihood estimation of time to first event in the presence of data gaps and multiple events.

Journal Article Stat Methods Med Res · April 2016 We propose a novel likelihood method for analyzing time-to-event data when multiple events and multiple missing data intervals are possible prior to the first observed event for a given subject. This research is motivated by data obtained from a heart moni ... Full text Link to item Cite

Independent Evaluation of a Mechanical Hip Socket Navigation System in Total Hip Arthroplasty.

Journal Article J Arthroplasty · March 2016 BACKGROUND: Acetabular cup malpositioning during total hip arthroplasty may lead to impingement, instability, wear-induced osteolysis, and increased rates of revision surgery. The purpose of this study was to independently evaluate the accuracy of acetabul ... Full text Link to item Cite

Outcomes of Bone Grafting of Bone Cysts After Total Ankle Arthroplasty.

Journal Article Foot Ankle Int · February 2016 BACKGROUND: The operative treatment of bone cysts after total ankle replacements (TAR) is not well described. Bone cysts may cause component migration, implant failure, and pain. Surgery is performed on cysts with the goals of reducing pain and preventing ... Full text Link to item Cite

The Effect of Obesity on Functional Outcomes and Complications in Total Ankle Arthroplasty.

Journal Article Foot Ankle Int · February 2016 BACKGROUND: The prevalence of obesity in the United States is staggering. Currently, the effect of obesity on third-generation total ankle replacement (TAR) is unknown. METHODS: We prospectively identified a consecutive series of 455 primary TARs operated ... Full text Link to item Cite

Ventricular arrhythmia burst is an independent indicator of larger infarct size even in optimal reperfusion in STEMI.

Journal Article J Electrocardiol · 2016 OBJECTIVE: We hypothesized that ventricular arrhythmia (VA) bursts during reperfusion phase are a marker of larger infarct size despite optimal epicardial and microvascular perfusion. METHODS: 126 STEMI patients were studied with 24h continuous, 12-lead Ho ... Full text Link to item Cite

Opioid-Based Analgesia: Impact on Total Joint Arthroplasty.

Journal Article J Arthroplasty · December 2015 The objective of this study was to characterize the impact of opioid-based analgesia in total joint arthroplasty. The primary outcomes were incidence of in-hospital complications, length of stay, and discharge destination. Six hundred and seventy-three pri ... Full text Link to item Cite

Impact of Diabetes on Outcome of Total Ankle Replacement.

Journal Article Foot Ankle Int · October 2015 BACKGROUND: As the incidence of diabetes mellitus (DM) grows, managing patients with diabetes and concomitant ankle arthritis poses a challenging clinical dilemma. While diabetes is known to be a risk factor for complications relating to open reduction and ... Full text Link to item Cite

Optimal timing of tracheostomy after trauma without associated head injury.

Journal Article J Surg Res · October 2015 BACKGROUND: Controversy exists over optimal timing of tracheostomy in patients with respiratory failure after blunt trauma. The study aimed to determine whether the timing of tracheostomy affects mortality in this population. METHODS: The 2008-2011 Nationa ... Full text Link to item Cite

Current Evidence Does Not Support Medicare's 3-Day Rule in Primary Total Joint Arthroplasty.

Journal Article Am J Orthop (Belle Mead NJ) · October 2015 Patients who undergo total joint arthroplasty and are destined for discharge to an extended-care facility--particularly Medicare beneficiaries--are required to have an inpatient stay of at least 3 consecutive days. The primary objective of this study was t ... Link to item Cite

Prospective evaluation of where reperfusion ventricular arrhythmia "bursts" fit into optimal reperfusion in STEMI.

Journal Article Int J Cardiol · September 15, 2015 BACKGROUND: Early reperfusion of ischemic myocytes is essential for optimal salvage in acute myocardial infarction. VA (ventricular arrhythmia) bursts after recanalization of the culprit vessel have been found to be related to larger infarct size (IS), usi ... Full text Link to item Cite

Medicare's 3-Day Rule: Time for a Rethink.

Journal Article J Arthroplasty · September 2015 A pilot study was undertaken to examine the impact of Medicare's 3-day rule on length of stay (LOS). One hundred consecutive patients who underwent primary total joint arthroplasty and were discharged to extended care facilities were retrospectively review ... Full text Link to item Cite

A randomized crossover study comparing a novel needle guidance technology for simulated internal jugular vein cannulation.

Journal Article Anesthesiology · September 2015 BACKGROUND: Despite ultrasound guidance for central line placement, complications persist, as exact needle location is often difficult to confirm with standard two-dimension ultrasound. A novel real-time needle guidance technology has recently become avail ... Full text Link to item Cite

Comparison of First- and Second-Generation Fixed-Bearing Total Ankle Arthroplasty Using a Modular Intramedullary Tibial Component.

Journal Article Foot Ankle Int · August 2015 BACKGROUND: This series reviews the clinical and radiographic outcomes of patients who underwent total ankle replacement (TAR) using first- and second-generations of a modern fixed-bearing prosthesis utilizing a modular intramedullary stem. METHODS: A cons ... Full text Link to item Cite

The Incidence of Propionibacterium acnes in Open Shoulder Surgery: A Controlled Diagnostic Study.

Journal Article J Bone Joint Surg Am · June 17, 2015 BACKGROUND: Propionibacterium acnes has arisen as the most common microorganism identified at the time of revision shoulder arthroplasty. There is limited evidence to suggest how frequently false-positive cultures occur. The purpose of this prospective con ... Full text Link to item Cite

Liposomal bupivacaine in forefoot surgery.

Journal Article Foot Ankle Int · May 2015 BACKGROUND: Liposomal bupivacaine is increasingly being utilized in attempts to provide prolonged local analgesia in the immediate postoperative period. The purpose of this study was to quantify the reduction in opioid consumption as well as postoperative ... Full text Link to item Cite

Preoperative pain level and patient expectation predict hospital length of stay after total hip arthroplasty.

Journal Article J Arthroplasty · April 2015 The purpose of this study was to identify preoperative predictors of length of stay after primary total hip arthroplasty in a patient population reflecting current trends toward shorter hospitalization and using readily obtainable factors that do not requi ... Full text Open Access Link to item Cite

Patient expectation is the most important predictor of discharge destination after primary total joint arthroplasty.

Journal Article J Arthroplasty · April 2015 The purpose of this study was to identify preoperative predictors of discharge destination after total joint arthroplasty. A retrospective study of three hundred and seventy-two consecutive patients who underwent primary total hip and knee arthroplasty was ... Full text Open Access Link to item Cite

Results from the IQ-CSRC prospective study support replacement of the thorough QT study by QT assessment in the early clinical phase.

Journal Article Clin Pharmacol Ther · April 2015 The QT effects of five "QT-positive" and one negative drug were tested to evaluate whether exposure-response analysis can detect QT effects in a small study with healthy subjects. Each drug was given to nine subjects (six for placebo) in two dose levels; p ... Full text Link to item Cite

Preoperative predictors of extended hospital length of stay following total knee arthroplasty.

Journal Article J Arthroplasty · March 2015 The purpose of this study was to identify the preoperative predictors of hospital length of stay after primary total knee arthroplasty in a patient population reflecting current trends toward shorter hospitalization and using readily obtainable factors tha ... Full text Open Access Link to item Cite

The Use of Radiation Therapy in Well-Differentiated Soft Tissue Sarcoma of the Extremities: An NCDB Review.

Journal Article Sarcoma · 2015 Objective. This study investigated patterns of utilization of radiation therapy (RT) and correlated this with overall survival by assessing patients with well-differentiated soft tissue sarcoma of the extremity (STS-E) in the National Cancer Database (NCDB ... Full text Link to item Cite

Prognostic implications of creatine kinase-MB measurements in ST-segment elevation myocardial infarction patients treated with primary percutaneous coronary intervention.

Journal Article Am Heart J · October 2014 BACKGROUND: Peak creatine kinase (CK)-MB concentration is related to reperfusion success and clinical outcomes after fibrinolytic therapy for acute myocardial infarction. However, prognostic implications of CK-MB measurements after primary percutaneous cor ... Full text Link to item Cite

Impact of perioperative allogeneic and autologous blood transfusion on acute wound infection following total knee and total hip arthroplasty.

Journal Article J Bone Joint Surg Am · February 19, 2014 BACKGROUND: Patients undergoing total hip or knee arthroplasty frequently receive blood transfusions. The relationship between transfusion and the risk of infection following total joint arthroplasty is unclear. In this study, we sought to examine the impa ... Full text Link to item Cite

Comparison of automated measurements of electrocardiographic intervals and durations by computer-based algorithms of digital electrocardiographs.

Journal Article Am Heart J · February 2014 BACKGROUND AND PURPOSE: Automated measurements of electrocardiographic (ECG) intervals are widely used by clinicians for individual patient diagnosis and by investigators in population studies. We examined whether clinically significant systematic differen ... Full text Link to item Cite

Electrocardiographic safety of cangrelor, a new intravenous antiplatelet agent: a randomized, double-blind, placebo- and moxifloxacin-controlled thorough QT study.

Journal Article J Cardiovasc Pharmacol · November 2013 Cangrelor is an intravenous P2Y12 inhibitor under investigation as an antiplatelet drug in the setting of acute coronary syndromes. To determine the electrophysiologic safety of parenteral cangrelor, cardiac repolarization effects were measured in 67 healt ... Full text Link to item Cite

Impact of choice of imaging modality accompanying outpatient exercise stress testing on outcomes and resource use after revascularization for acute coronary syndromes.

Journal Article Am Heart J · October 2013 BACKGROUND: Exercise stress testing is commonly obtained after percutaneous coronary intervention (PCI) performed for acute coronary syndromes (ACS). We compared the relationships between exercise echocardiography and nuclear testing after ACS-related PCI ... Full text Link to item Cite

Temporal trends in percutaneous coronary intervention outcomes among older patients in the United States.

Conference Am Heart J · August 2013 BACKGROUND: New percutaneous coronary intervention (PCI) device technologies are often rapidly adopted into clinical practice, yet few studies have examined the overall impact of these new technologies on patient outcomes in community practice. METHODS: In ... Full text Link to item Cite

Use of stress testing and diagnostic catheterization after coronary stenting: association of site-level patterns with patient characteristics and outcomes in 247,052 Medicare beneficiaries.

Journal Article J Am Coll Cardiol · July 30, 2013 OBJECTIVES: The aim of this study was to determine diagnostic testing patterns after percutaneous coronary intervention (PCI). BACKGROUND: Little is known about patterns of diagnostic testing after PCI in the United States or the relationship of these patt ... Full text Link to item Cite

ECG-based signal analysis technologies for evaluating patients with acute coronary syndrome: a systematic review.

Journal Article J Electrocardiol · 2013 BACKGROUND/OBJECTIVES: Timely identification of cardiac ischemia is critical in patients with acute coronary syndrome (ACS). The first test is often the standard, resting 12-lead ECG. Given its limitations, signal analysis enhancements have been proposed. ... Full text Link to item Cite

Patterns of stress testing and diagnostic catheterization after coronary stenting in 250 350 medicare beneficiaries.

Journal Article Circ Cardiovasc Imaging · January 1, 2013 BACKGROUND: Patterns of noninvasive stress test (ST) and invasive coronary angiography (CA) utilization after percutaneous coronary intervention (PCI) are not well described in older populations. METHODS AND RESULTS: We linked National Cardiovascular Data ... Full text Link to item Cite

Patterns and predictors of stress testing modality after percutaneous coronary stenting: data from the NCDR(®).

Journal Article JACC Cardiovasc Imaging · October 2012 OBJECTIVES: We evaluated temporal trends and geographic variation in choice of stress testing modality after percutaneous coronary intervention (PCI), as well as associations between modality and procedure use after testing. BACKGROUND: Stress testing is f ... Full text Link to item Cite

Downstream testing and subsequent procedures after coronary computed tomographic angiography following coronary stenting in patients ≥65 years of age.

Journal Article Am J Cardiol · September 15, 2012 Limited data are available on the use of coronary computed tomographic angiography (CCTA) in patients who have received percutaneous coronary intervention (PCI). To evaluate patterns of cardiac testing including CCTA after PCI, we created a retrospective o ... Full text Link to item Cite

Detection of QT prolongation using a novel electrocardiographic analysis algorithm applying intelligent automation: prospective blinded evaluation using the Cardiac Safety Research Consortium electrocardiographic database.

Journal Article Am Heart J · March 2012 BACKGROUND: The Cardiac Safety Research Consortium (CSRC) provides both "learning" and blinded "testing" digital electrocardiographic (ECG) data sets from thorough QT (TQT) studies annotated for submission to the US Food and Drug Administration (FDA) to de ... Full text Link to item Cite

The Cardiac Safety Research Consortium ECG database.

Journal Article J Electrocardiol · 2012 The Cardiac Safety Research Consortium (CSRC) ECG database was initiated to foster research using anonymized, XML-formatted, digitized ECGs with corresponding descriptive variables from placebo- and positive-control arms of thorough QT studies submitted to ... Full text Link to item Cite

Design considerations for a study to evaluate the impact of smoking cessation treatment on stimulant use outcomes in stimulant-dependent individuals.

Journal Article Contemp Clin Trials · January 2012 Cigarette smoking is prevalent in cocaine/methamphetamine-dependent patients and associated with significant morbidity and mortality, yet, the provision of smoking cessation treatment in conjunction with substance use disorder (SUD) treatment is not standa ... Full text Link to item Cite

The Cardiac Safety Research Consortium electrocardiogram warehouse: thorough QT database specifications and principles of use for algorithm development and testing.

Journal Article Am Heart J · December 2010 This document examines the formation, structure, and principles guiding the use of electrocardiogram (ECG) data sets obtained during thorough QT studies that have been derived from the ECG Warehouse of the Cardiac Safety Research Consortium (CSRC). These p ... Full text Link to item Cite

Safety and feasibility of adjunctive antiplatelet therapy with intravenous elinogrel, a direct-acting and reversible P2Y12 ADP-receptor antagonist, before primary percutaneous intervention in patients with ST-elevation myocardial infarction: the Early Rapid ReversAl of platelet thromboSis with intravenous Elinogrel before PCI to optimize reperfusion in acute Myocardial Infarction (ERASE MI) pilot trial.

Journal Article Am Heart J · December 2009 BACKGROUND: Inhibition of the P2Y12 ADP-receptor with oral antiplatelet agents given to patients undergoing primary percutaneous coronary intervention (PCI) for ST-elevation myocardial infarction (STEMI) is associated with improved outcomes, but this strat ... Full text Link to item Cite

QT as a safety biomarker in drug development.

Journal Article Clin Pharmacol Ther · July 2009 Featured Publication The cardiovascular safety of new drugs is an overarching concern for all stakeholders: the pharmaceutical industry and the US Food and Drug Administration (FDA) prior to approval and doctors and patients during postrelease drug use. Of the many cardiac saf ... Full text Link to item Cite

Intracoronary KAI-9803 as an adjunct to primary percutaneous coronary intervention for acute ST-segment elevation myocardial infarction.

Journal Article Circulation · February 19, 2008 BACKGROUND: KAI-9803, a delta-protein kinase C inhibitor, has been shown to ameliorate injury associated with ischemia and reperfusion in animal models of acute myocardial infarction (MI). METHODS AND RESULTS: Direct Inhibition of delta-Protein Kinase C En ... Full text Link to item Cite

Comparison of ST-segment resolution with combined fibrinolytic and glycoprotein IIb/IIIa inhibitor therapy versus fibrinolytic alone (data from four clinical trials).

Journal Article Am J Cardiol · March 1, 2005 Featured Publication We compared combination fibrinolytic plus glycoprotein IIb/IIIa inhibitor therapy with stand-alone fibrinolysis with respect to speed and stability of reperfusion in patients who had acute ST-segment elevation myocardial infarction; data were obtained from ... Full text Link to item Cite

An academic ECG core lab perspective of the FDA initiative for digital ECG capture and data management in large-scale clinical trials

Journal Article Drug Information Journal · 2005 Maximal utility of accessible data is attractive to all partners in clinical research, whether it directly improves patient care or more accurately allows identification of the safety and efficacy of a new drug or procedure. The Food and Drug Administratio ... Cite

Assessment of derived 12-lead electrocardiograms using general and patient-specific reconstruction strategies at rest and during transient myocardial ischemia.

Journal Article Am J Cardiol · December 15, 2004 Featured Publication Twelve-lead ST-segment monitoring is a widely used tool for capturing focal ischemia and transient intermittent episodes. However, continuous registration of all 10 electrodes is impractical in clinical settings. This study investigated the accuracy of 2 d ... Full text Link to item Cite

J. Maxwell Chamberlain Memorial Paper. Early fundoplication prevents chronic allograft dysfunction in patients with gastroesophageal reflux disease.

Journal Article Ann Thorac Surg · October 2004 BACKGROUND: Chronic allograft dysfunction limits the long-term success of lung transplantation. Increasing evidence suggests nonimmune mediated injury such as due to reflux contributes to the development of bronchiolitis obliterans syndrome. We have previo ... Full text Link to item Cite

Association of the timing of ST-segment resolution with TIMI myocardial perfusion grade in acute myocardial infarction.

Journal Article Am Heart J · May 2004 Featured Publication BACKGROUND: More complete ST-segment resolution (ST res) in acute myocardial infarction (MI) has been associated with better epicardial and myocardial reperfusion as assessed with the Thrombolysis in Myocardial Infarction (TIMI) flow grade (TFG) and the TI ... Full text Link to item Cite

Combining baseline clinical descriptors and real-time response to therapy: the incremental prognostic value of continuous ST-segment monitoring in acute myocardial infarction.

Journal Article Am Heart J · April 2004 Featured Publication BACKGROUND: Clinical descriptors and ST-segment recovery variables hold prognostic information for clinical outcome after thrombolysis for acute myocardial infarction (MI). We sought to define the incremental prognostic value of continuous 12-lead ST-segme ... Full text Link to item Cite

Improved speed and stability of ST-segment recovery with reduced-dose tenecteplase and eptifibatide compared with full-dose tenecteplase for acute ST-segment elevation myocardial infarction.

Journal Article J Am Coll Cardiol · February 18, 2004 Featured Publication OBJECTIVES: This sub-study of the Integrilin and Tenecteplase in Acute Myocardial Infarction (INTEGRITI) trial evaluated of the impact of combination reperfusion therapy with reduced-dose tenecteplase plus eptifibatide on continuous ST-segment recovery and ... Full text Link to item Cite

Usefulness of frequent arrhythmias after epicardial recanalization in anterior wall acute myocardial infarction as a marker of cellular injury leading to poor recovery of left ventricular function.

Journal Article Am J Cardiol · November 15, 2003 Featured Publication Ventricular arrhythmias are associated with epicardial reperfusion but may also be a sign of cellular injury, which affects recovery of left ventricular (LV) function. To assess the correlation between reperfusion arrhythmias and the change in LV function ... Full text Link to item Cite

Reduction of myocardial ischemic injury following coronary intervention (the MC-1 to Eliminate Necrosis and Damage trial).

Journal Article Am J Cardiol · September 15, 2003 Featured Publication Myocardial ischemic injury complicating acute myocardial infarction (AMI) and coronary revascularization procedures remains an unresolved clinical dilemma. In preclinical studies, treatment with pyridoxal-5'-phosphate monohydrate (MC-1), a vitamin B6 metab ... Full text Link to item Cite

Correlations between preprocedure mood and clinical outcome in patients undergoing coronary angioplasty.

Journal Article Cardiol Rev · 2003 Featured Publication We studied the relationship between mood and mood shift immediately before percutaneous coronary intervention (PCI) and 3 end points: total ischemic burden during PCI, adverse cardiac end points (ACE) after PCI, and death by 6-month follow up. Patients (n ... Full text Link to item Cite

Integrative noetic therapies as adjuncts to percutaneous intervention during unstable coronary syndromes: Monitoring and Actualization of Noetic Training (MANTRA) feasibility pilot.

Journal Article Am Heart J · November 2001 Featured Publication BACKGROUND: Patients undergoing percutaneous coronary intervention (PCI) for unstable coronary syndromes have substantial emotional and spiritual distress that may promote procedural complications. Noetic (nonpharmacologic) therapies may reduce anxiety, pa ... Full text Link to item Cite

ST-Segment recovery adds to the assessment of TIMI 2 and 3 flow in predicting infarct wall motion after thrombolytic therapy.

Journal Article Circulation · May 9, 2000 Featured Publication BACKGROUND: Early resolution of ST-segment elevation (ST-segment recovery) is associated with an improved outcome after infarction. Whether this relation is present in patients with Thrombolysis In Myocardial Infarction (TIMI) grade 2 or 3 flow (ie, patent ... Full text Link to item Cite

Myocardial ischemia correlates with reduced fibrinolytic activity following peripheral vascular surgery.

Journal Article J Clin Anesth · March 2000 Featured Publication STUDY OBJECTIVES: To evaluate the relationship between perioperative ischemia and serial concentrations of D-dimer, which is a sensitive and specific marker of fibrinolytic activity. Myocardial ischemia and infarction are well-recognized complications of p ... Full text Link to item Cite

Prognostic implications of TIMI flow grade in the infarct related artery compared with continuous 12-lead ST-segment resolution analysis. Reexamining the "gold standard" for myocardial reperfusion assessment.

Journal Article J Am Coll Cardiol · March 1, 2000 Featured Publication OBJECTIVE: To compare the prognostic significance of reperfusion assessment by Thrombolysis in Myocardial Infarction (TIMI) flow grade in the infarct related artery and ST-segment resolution analysis, by correlating with clinical outcomes in patients with ... Full text Link to item Cite

Neurosurgical evacuation of intracranial hemorrhage after thrombolytic therapy for acute myocardial infarction: experience from the GUSTO-I trial. Global Utilization of Streptokinase and tissue-plasminogen activator (tPA) for Occluded Coronary Arteries.

Journal Article Am Heart J · September 1999 Featured Publication BACKGROUND: Intracranial hemorrhage is an uncommon but very dangerous complication in patients receiving thrombolytic therapy for acute myocardial infarction. Neurosurgical evacuation is often an available treatment option. However, the association between ... Full text Link to item Cite

Comparison of slow oscillating versus fast balloon inflation strategies for coronary angioplasty.

Journal Article Am J Cardiol · March 1, 1999 Featured Publication Previous studies suggest that slow and/or oscillating balloon inflation during coronary angioplasty may decrease the incidence of coronary dissection and improve clinical outcomes. To compare the effect of slow oscillating versus conventional fast inflatio ... Full text Link to item Cite

Novel applications of ECG monitoring for the quantification of noetic phenomena

Journal Article Journal of Electrocardiology · January 1, 1999 A safety and efficacy study of nondrug, nondevice 'noetic' medical interventions requires unique clinical trial design elements and tools. Although the precise mechanisms through which meditative or spiritual practices might influence clinical outcomes may ... Full text Cite

Combining thrombolysis with the platelet glycoprotein IIb/IIIa inhibitor lamifiban: results of the Platelet Aggregation Receptor Antagonist Dose Investigation and Reperfusion Gain in Myocardial Infarction (PARADIGM) trial.

Journal Article J Am Coll Cardiol · December 1998 OBJECTIVES: The trial was designed to assess the safety, pharmacodynamics and effects on reperfusion of the platelet glycoprotein (GP) IIb/IIIa inhibitor lamifiban when given with thrombolysis to patients with ST segment elevation acute myocardial infarcti ... Full text Link to item Cite

Prediction of 30-day mortality among patients with thrombolysis-related intracranial hemorrhage.

Journal Article Circulation · October 6, 1998 Featured Publication BACKGROUND: Limited information exists on risk factors for mortality after thrombolysis-related intracranial hemorrhage. We wished to determine the characteristics associated with 30-day mortality after thrombolysis-related intracranial hemorrhage. METHODS ... Full text Link to item Cite

Comparison of the ABC/2 estimation technique to computer-assisted volumetric analysis of intraparenchymal and subdural hematomas complicating the GUSTO-1 trial.

Journal Article Stroke · September 1998 Featured Publication BACKGROUND AND PURPOSE: The volume of an intracerebral hemorrhage has been shown to be an important independent predictor of mortality in several reports. A technique for estimating hematoma volume, known as the ABC/2 method, has been proven a reliable, si ... Full text Link to item Cite

A randomized trial of vascular hemostasis techniques to reduce femoral vascular complications after coronary intervention.

Journal Article Am J Cardiol · April 15, 1998 Featured Publication This report details a prospectively randomized clinical trial comparing mechanical clamp compression to hand applied pressure for attaining vascular hemostasis after coronary intervention. Effectiveness was determined by comparing the incidence of femoral ... Full text Link to item Cite

Thrombolysis-related intracranial hemorrhage: a radiographic analysis of 244 cases from the GUSTO-1 trial with clinical correlation. Global Utilization of Streptokinase and Tissue Plasminogen Activator for Occluded Coronary Arteries.

Journal Article Stroke · March 1998 Featured Publication BACKGROUND AND PURPOSE: Intracranial hemorrhage (ICH) is a serious complication of thrombolytic therapy. We systematically reviewed the radiographic features of 244 cases of symptomatic ICH complicating thrombolysis for acute myocardial infarction in the G ... Full text Link to item Cite

A Comparison of Static Serial vs Continuous ST-Segment Recovery to Predict Outcome After Lytics for MI

Journal Article Journal of the American College of Cardiology · February 1998 Full text Cite

Device implementation, validation, and application assessment of two continuous 12-lead ECG monitors during percutaneous transluminal coronary angioplasty: description of the validation method and implications for clinical trials.

Journal Article J Electrocardiol · 1998 Featured Publication Comparability of clinical and research data sets may be undermined if the instruments used to acquire them vary. Even when standard 12-lead electrocardiographic formats are used for monitoring, proprietary signal processing techniques and sampling interval ... Full text Link to item Cite

Comparative prognostic significance of simultaneous versus independent resolution of ST segment depression relative to ST segment elevation during acute myocardial infarction.

Journal Article J Am Coll Cardiol · November 15, 1997 Featured Publication OBJECTIVES: We sought to determine the prognostic significance of simultaneous versus independent resolution of ST segment depression that occurs concomitant with ST segment elevation during acute myocardial infarction (AMI). BACKGROUND: ST segment depress ... Full text Link to item Cite

Electrocardiographic differentiation of the ST-segment depression of acute myocardial injury due to the left circumflex artery occlusion from that of myocardial ischemia of nonocclusive etiologies.

Journal Article Am J Cardiol · August 15, 1997 Featured Publication Lead distributions of peak ST-segment depression were compared between patients undergoing left circumflex artery percutaneous transluminal coronary angioplasty and exercise tolerance test. Localization of peak ST-segment depression to leads V2 or V3 was 9 ... Full text Link to item Cite

Coronary revascularization surgery after myocardial infarction: impact of bypass surgery on survival after thrombolysis. GUSTO Investigators. Global Utilization of Streptokinase and Tissue Plasminogen Activator for Occluded Coronary Arteries.

Journal Article J Am Coll Cardiol · February 1997 Featured Publication OBJECTIVES: This study sought to investigate the impact of surgical revascularization on outcome after myocardial infarction. BACKGROUND: Small variations in rates of coronary artery bypass graft surgery (CABG) were noted among thrombolytic regimens in the ... Full text Link to item Cite

The paradigm for anti-platelet effect on continuous 12-lead ST-segment recovery in acute MI

Journal Article JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY · February 1, 1997 Link to item Cite

Incidence and clinical relevance of the occurrence of bundle-branch block in patients treated with thrombolytic therapy.

Journal Article Circulation · November 15, 1996 Featured Publication BACKGROUND: Whether thrombolytic therapy alters the incidence and clinical outcome of bundle-branch block is unclear. METHODS AND RESULTS: We examined the occurrence of new-onset bundle-branch block, both transient and persistent, in 681 patients with acut ... Full text Link to item Cite

Non-invasive prediction of reperfusion and coronary artery patency by continuous ST segment monitoring in the GUSTO-I trial.

Journal Article Eur Heart J · May 1996 Featured Publication In the GUSTO-I ECG ischaemia monitoring substudy, 1067 patients underwent continuous ST segment monitoring, using vector-derived 12-lead (406 patients), 12-lead (373 patients) and 3-lead Holter (288 patients) ECG recording systems. Simultaneous angiograms ... Full text Link to item Cite

Rebound increase in thrombin generation and activity after cessation of intravenous heparin in patients with acute coronary syndromes

Journal Article Journal of Intravenous Nursing · May 1, 1996 Background: The abrupt cessation of heparin and other thrombin inhibitors when used to treat acute coronary syndromes has been accompanied by a clustering of thrombotic events. It is unknown whether these events are the result of inadequate antithrombin th ... Cite

Rebound increase in thrombin generation and activity after cessation of intravenous heparin in patients with acute coronary syndromes.

Journal Article Circulation · April 1, 1995 Featured Publication BACKGROUND: The abrupt cessation of heparin and other thrombin inhibitors when used to treat acute coronary syndromes has been accompanied by a clustering of thrombotic events. It is unknown whether these events are the result of inadequate antithrombin th ... Full text Link to item Cite

Comparison of continuous ST-segment recovery analysis with methods using static electrocardiograms for noninvasive patency assessment during acute myocardial infarction. Thrombolysis and Angioplasty in Myocardial Infarction (TAMI) 7 Study Group.

Journal Article Am J Cardiol · June 1, 1994 Featured Publication Continuous ST-segment recovery analysis and 5 static methods using ST-segment comparison between a pre- and post-treatment electrocardiogram were compared for their ability to predict infarct-related artery patency in 82 patients with acute myocardial infa ... Full text Link to item Cite