Scholars@Duke
Victor Hasselblad

Victor Hasselblad

Professor Emeritus of Biostatistics & Bioinformatics
Biostatistics & Bioinformatics, Division of Biostatistics
hasse002@mc.duke.edu
Duke Box 2721, Durham, NC 27710
Hock Plaza Suite 1102, Suite 1102 Hock Plaza, Durham, NC 27705

Selected Publications

Systematic review and meta-analysis of endovascular and surgical revascularization for patients with chronic lower extremity venous insufficiency and varicose veins.

Journal Article Am Heart J · February 2018 BACKGROUND: Chronic lower extremity venous disease (LECVD) is twice as prevalent as coronary heart disease, and invasive therapies to treat LECVD accounted for an estimated $290 million in Medicare expenditures in 2015. Despite increasing use of these inva ... Full text Link to item Cite

Predictors of perioperative major bleeding in patients who interrupt warfarin for an elective surgery or procedure: Analysis of the BRIDGE trial.

Journal Article Am Heart J · January 2018 BACKGROUND: The use of low-molecular weight heparin bridge therapy during warfarin interruption for elective surgery/procedures increases bleeding. Other predictors of bleeding in this setting are not well described. METHODS: BRIDGE was a randomized, doubl ... Full text Link to item Cite

Cardiovascular adverse events in the drug-development program of bupropion for smoking cessation: A systematic retrospective adjudication effort.

Journal Article Clin Cardiol · October 2017 BACKGROUND: In 2011, the US Food and Drug Administration requested that GlaxoSmithKline perform retrospective adjudication of cardiovascular (CV) events reported in the bupropion drug-development trials for smoking cessation. HYPOTHESIS: Retrospective adju ... Full text Link to item Cite

Antithrombotic agents for secondary prevention after acute coronary syndromes: A systematic review and network meta-analysis.

Journal Article Int J Cardiol · August 15, 2017 BACKGROUND: Nine oral antithrombotic medications currently available in the United States and Europe have been studied in clinical trials for secondary prevention of cardiac events following acute coronary syndrome (ACS). Few combinations of these medicati ... Full text Link to item Cite

Levonorgestrel Intrauterine Device as an Endometrial Cancer Prevention Strategy in Obese Women: A Cost-Effectiveness Analysis.

Journal Article Obstet Gynecol · October 2016 OBJECTIVE: To estimate the cost-effectiveness of the levonorgestrel intrauterine device (IUD) as an endometrial cancer prevention strategy in obese women. METHODS: A modified Markov model was used to compare IUD placement at age 50 with usual care among wo ... Full text Link to item Cite

Power considerations for trials of two experimental arms versus a standard active control or placebo.

Journal Article Stat Methods Med Res · October 2016 The power of the two-experimental arm trial depends on three choices: (1) when one arm is dropped (if at all); (2) the final testing procedure, assuming no dropping; and (3) the sampling ratio for the three arms. Multiple-arm designs require critical value ... Full text Link to item Cite

The Systemic Juvenile Idiopathic Arthritis Cohort of the Childhood Arthritis and Rheumatology Research Alliance Registry: 2010-2013.

Journal Article J Rheumatol · September 2016 OBJECTIVE: We aimed to identify the (1) demographic/clinical characteristics, (2) medication usage trends, (3) variables associated with worse disease activity, and (4) characteristics of patients with persistent chronic arthritis in the Childhood Arthriti ... Full text Link to item Cite

Proceedings of the 2016 Childhood Arthritis and Rheumatology Research Alliance (CARRA) Scientific Meeting : Toronto, Canada. 14-17 April 2016.

Journal Article Pediatr Rheumatol Online J · July 12, 2016 P1 Serologic evidence of gut-driven systemic inflammation in juvenile idiopathic arthritis Lampros Fotis, Nur Shaikh, Kevin Baszis, Anthony French, Phillip Tarr P2 Oral health and anti-citrullinated peptide antibodies (ACPA) in juvenile idiopathic arthriti ... Full text Open Access Link to item Cite

Nesiritide in patients hospitalized for acute heart failure: does timing matter? Implication for future acute heart failure trials.

Journal Article Eur J Heart Fail · June 2016 AIMS: It remains unclear if early administration of i.v. nesiritide in patients hospitalized with acute heart failure (AHF) is associated with improved clinical outcomes. METHODS AND RESULTS: We analysed data from 7007 patients enrolled in ASCEND-HF to exa ... Full text Link to item Cite

Dichotomous Relationship Between Age and 30-Day Death or Rehospitalization in Heart Failure Patients Admitted With Acute Decompensated Heart Failure: Results From the ASCEND-HF Trial.

Journal Article J Card Fail · June 2016 BACKGROUND: Younger age as an independent predictor of death or all-cause rehospitalization at 30 days post-randomization for hospitalized heart failure (HF) patients has not been well described. METHODS AND RESULTS: ASCEND-HF enrolled 7141 hospitalized ac ... Full text Link to item Cite

Catheter ablation for ventricular tachycardia (VT) in patients with ischemic heart disease: a systematic review and a meta-analysis of randomized controlled trials.

Journal Article J Interv Card Electrophysiol · March 2016 BACKGROUND: Patients with ischemic heart disease may have implantable cardioverter defibrillators (ICDs) implanted for primary or secondary prevention of sudden cardiac death. Although ICD shocks can be life saving, in some patients, they have been associa ... Full text Link to item Cite

Torsemide Versus Furosemide in Patients With Acute Heart Failure (from the ASCEND-HF Trial).

Journal Article Am J Cardiol · February 1, 2016 Furosemide is the most commonly used loop diuretic in patients with heart failure (HF) despite data suggesting potential pharmacologic and antifibrotic benefits with torsemide. We investigated patients with HF in Acute Study of Clinical Effectiveness of Ne ... Full text Link to item Cite

A Systematic Review of Race and Ethnicity in Hepatitis C Clinical Trial Enrollment.

Journal Article J Natl Med Assoc · February 2016 The African American/Black population in the United States (US) is disproportionately affected by hepatitis C virus (HCV) and has lower response rates to current treatments. This analysis evaluates the participation of African American/Blacks in North Amer ... Full text Open Access Link to item Cite

Effect of the REG1 anticoagulation system versus bivalirudin on outcomes after percutaneous coronary intervention (REGULATE-PCI): a randomised clinical trial.

Journal Article Lancet · January 23, 2016 BACKGROUND: REG1 is a novel anticoagulation system consisting of pegnivacogin, an RNA aptamer inhibitor of coagulation factor IXa, and anivamersen, a complementary sequence reversal oligonucleotide. We tested the hypothesis that near complete inhibition of ... Full text Link to item Cite

Body mass index and mortality in endometrial cancer: A systematic review and meta-analysis.

Journal Article Gynecol Oncol · January 2016 OBJECTIVE: To evaluate the association between body mass index (BMI) and mortality in women with endometrial cancer. METHODS: A systematic review was performed utilizing a Medline search with Mesh keywords 'endometrial neoplasms' and ('body mass index' or ... Full text Link to item Cite

Psyllium fiber improves glycemic control proportional to loss of glycemic control: a meta-analysis of data in euglycemic subjects, patients at risk of type 2 diabetes mellitus, and patients being treated for type 2 diabetes mellitus.

Journal Article Am J Clin Nutr · December 2015 BACKGROUND: A number of health benefits are associated with intake of soluble, viscous, gel-forming fibers, including reduced serum cholesterol and the attenuation of postprandial glucose excursions. OBJECTIVE: We assess the effects of psyllium, which is a ... Full text Link to item Cite

Individual Proton Pump Inhibitors and Outcomes in Patients With Coronary Artery Disease on Dual Antiplatelet Therapy: A Systematic Review.

Journal Article J Am Heart Assoc · October 29, 2015 BACKGROUND: Observational studies evaluating the possible interaction between proton pump inhibitors (PPIs) and clopidogrel have shown mixed results. We conducted a systematic review comparing the safety of individual PPIs in patients with coronary artery ... Full text Open Access Link to item Cite

Comparative effectiveness of torsemide versus furosemide in heart failure patients: insights from the PROTECT trial.

Journal Article Future Cardiol · September 2015 AIM: The authors assessed the comparative effectiveness of torsemide versus furosemide in the PROTECT trial. METHODS: The authors assessed the relationship between loop diuretic at discharge and death or cardiovascular/renal hospitalization within 30 days, ... Full text Link to item Cite

Perioperative Bridging Anticoagulation in Patients with Atrial Fibrillation.

Journal Article N Engl J Med · August 27, 2015 BACKGROUND: It is uncertain whether bridging anticoagulation is necessary for patients with atrial fibrillation who need an interruption in warfarin treatment for an elective operation or other elective invasive procedure. We hypothesized that forgoing bri ... Full text Link to item Cite

Worsening heart failure during hospitalization for acute heart failure: Insights from the Acute Study of Clinical Effectiveness of Nesiritide in Decompensated Heart Failure (ASCEND-HF).

Journal Article Am Heart J · August 2015 BACKGROUND: Despite initial in-hospital treatment of acute heart failure (HF), some patients experience worsening HF (WHF). There are limited data about the outcomes and characteristics of patients who experience in-hospital WHF. METHODS AND RESULTS: We as ... Full text Link to item Cite

Predictors of clinical outcomes in acute decompensated heart failure: Acute Study of Clinical Effectiveness of Nesiritide in Decompensated Heart Failure outcome models.

Journal Article Am Heart J · August 2015 BACKGROUND: Patients hospitalized for acute decompensated heart failure (ADHF) are at high risk for early mortality and rehospitalization. Risk stratification of ADHF using clinically available data on admission is increasingly important to integrate with ... Full text Link to item Cite

Complications from prophylactic replacement of cardiac implantable electronic device generators in response to United States Food and Drug Administration recall: A systematic review and meta-analysis.

Journal Article Heart Rhythm · July 2015 BACKGROUND: The number of cardiac implantable electronic device (CIED) recalls and advisories has increased over the past 3 decades, yet no consensus exists on how to best manage patients with these CIEDs, partially because rates of complications from prop ... Full text Link to item Cite

Supervised vs unsupervised exercise for intermittent claudication: A systematic review and meta-analysis.

Journal Article Am Heart J · June 2015 BACKGROUND: Supervised exercise (SE) is widely accepted as an effective therapy for intermittent claudication (IC), but its use is limited by cost. Unsupervised exercise (UE) represents a less costly alternative. We assessed the comparative effectiveness o ... Full text Link to item Cite

Comparative Effectiveness of Medical Therapy, Supervised Exercise, and Revascularization for Patients With Intermittent Claudication: A Network Meta-analysis.

Journal Article Clin Cardiol · June 2015 BACKGROUND: There are limited data on the comparative effectiveness of medical therapy, supervised exercise, and revascularization to improve walking and quality of life in patients with intermittent claudication (IC). HYPOTHESIS: Supervised exercise and r ... Full text Link to item Cite

Loop diuretic dose adjustments after a hospitalization for heart failure: insights from ASCEND-HF.

Conference Eur J Heart Fail · March 2015 AIMS: Loop diuretics are a cornerstone of heart failure (HF) treatment, but data regarding diuretic dose adjustments after a HF hospitalization and the association with subsequent outcomes are limited. This study was therefore conducted to determine these ... Full text Link to item Cite

Conflicting results between randomized trials and observational studies on the impact of proton pump inhibitors on cardiovascular events when coadministered with dual antiplatelet therapy: systematic review.

Journal Article Circ Cardiovasc Qual Outcomes · January 2015 BACKGROUND: Discordant results have been reported on the effects of concomitant use of proton pump inhibitors (PPIs) and dual antiplatelet therapy (DAPT) for cardiovascular outcomes. We conducted a systematic review comparing the effectiveness and safety o ... Full text Link to item Cite

Hypotension during hospitalization for acute heart failure is independently associated with 30-day mortality: findings from ASCEND-HF.

Journal Article Circ Heart Fail · November 2014 BACKGROUND: Outcomes associated with episodes of hypotension while hospitalized with acute decompensated heart failure are not well understood. METHODS AND RESULTS: Using data from Acute Study of Clinical Effectiveness of Nesiritide in Decompensated Heart ... Full text Link to item Cite

Dual antiplatelet therapy with or without oral anticoagulation in the postdischarge management of acute coronary syndrome patients with an indication for long term anticoagulation: a systematic review.

Journal Article J Thromb Thrombolysis · October 2014 Currently, there is a lack of consensus among guidelines for the postdischarge treatment of patients presenting with acute coronary syndrome (ACS) who have a long-term indication for anticoagulation. We conducted a systematic review comparing the safety an ... Full text Link to item Cite

Nesiritide, renal function, and associated outcomes during hospitalization for acute decompensated heart failure: results from the Acute Study of Clinical Effectiveness of Nesiritide and Decompensated Heart Failure (ASCEND-HF).

Journal Article Circulation · September 16, 2014 BACKGROUND: Contradictory results have been reported on the effects of nesiritide on renal function in patients with acute decompensated heart failure. We studied the effects of nesiritide on renal function during hospitalization for acute decompensated he ... Full text Link to item Cite

Pharmacologic and behavioral interventions to improve cardiovascular risk factors in adults with serious mental illness: a systematic review and meta-analysis.

Journal Article J Clin Psychiatry · May 2014 OBJECTIVE: Individuals with serious mental illness have high rates of cardiovascular disease (CVD) risk factors and mortality. This systematic review was conducted to evaluate pharmacologic and behavioral interventions to reduce CVD risk in adults with ser ... Full text Link to item Cite

Comparative effectiveness of endovascular and surgical revascularization for patients with peripheral artery disease and critical limb ischemia: systematic review of revascularization in critical limb ischemia.

Journal Article Am Heart J · April 2014 BACKGROUND: For patients with critical limb ischemia (CLI), the optimal treatment to enhance limb preservation, prevent death, and improve functional status is unknown. We performed a systematic review and meta-analysis to assess the comparative effectiven ... Full text Link to item Cite

Efficacy and tolerability of treatments for chronic cough: a systematic review and meta-analysis.

Journal Article Chest · December 2013 BACKGROUND: Understanding the comparative effectiveness of treatments for patients with unexplained or refractory cough is important to increase awareness of proven therapies and their potential adverse effects in this unique population. METHODS: We perfor ... Full text Link to item Cite

Evaluating cough assessment tools: a systematic review.

Journal Article Chest · December 2013 BACKGROUND: Little is known about the comparative validity, reliability, or responsiveness of instruments for assessing cough frequency or impact, where the term impact encompasses both cough severity and the impact of cough on health-related quality of li ... Full text Link to item Cite

Effect of levosimendan on survival and adverse events after cardiac surgery: a meta-analysis.

Journal Article J Cardiothorac Vasc Anesth · December 2013 OBJECTIVE: Left ventricular systolic dysfunction is associated with increased morbidity and mortality in patients undergoing cardiac surgery. The authors performed a meta-analysis investigating the effects of levosimendan in cardiac surgery patients with a ... Full text Link to item Cite

Oral contraceptives and risk of ovarian cancer and breast cancer among high-risk women: a systematic review and meta-analysis.

Journal Article J Clin Oncol · November 20, 2013 PURPOSE: To estimate the risks of ovarian cancer and breast cancer associated with oral contraceptive (OC) use among women at elevated risk owing to mutations in BRCA1/2 or a strong family history. METHODS: We searched PubMed, Embase, the Cochrane Database ... Full text Link to item Cite

EPC mobilization after erythropoietin treatment in acute ST-elevation myocardial infarction: the REVEAL EPC substudy.

Journal Article J Thromb Thrombolysis · November 2013 Erythropoietin (EPO) was hypothesized to mitigate reperfusion injury, in part via mobilization of endothelial progenitor cells (EPCs). The REVEAL trial found no reduction in infarct size with a single dose of EPO (60,000 U) in patients with ST-segment elev ... Full text Link to item Cite

Oral contraceptive use and risk of breast, cervical, colorectal, and endometrial cancers: a systematic review.

Journal Article Cancer Epidemiol Biomarkers Prev · November 2013 Oral contraceptives may influence the risk of certain cancers. As part of the AHRQ Evidence Report, Oral Contraceptive Use for the Primary Prevention of Ovarian Cancer, we conducted a systematic review to estimate associations between oral contraceptive us ... Full text Link to item Cite

Transtibial versus independent drilling techniques for anterior cruciate ligament reconstruction: a systematic review, meta-analysis, and meta-regression.

Journal Article Am J Sports Med · November 2013 BACKGROUND: While numerous cadaveric, in vivo, and clinical studies have compared transtibial and independent drilling of femoral tunnels during anterior cruciate ligament reconstruction, there is no evidence-based consensus on which technique affords the ... Full text Link to item Cite

Prognostic relevance of baseline pro- and anti-inflammatory markers in STEMI: an APEX AMI substudy.

Journal Article Int J Cardiol · October 3, 2013 BACKGROUND: Plaque rupture, acute ischemia, and necrosis in acute coronary syndromes are accompanied by concurrent pro- and anti-inflammatory cascades. Whether STEMI clinical prediction models can be improved with the addition of baseline inflammatory biom ... Full text Link to item Cite

Effects of nesiritide and predictors of urine output in acute decompensated heart failure: results from ASCEND-HF (acute study of clinical effectiveness of nesiritide and decompensated heart failure).

Journal Article J Am Coll Cardiol · September 24, 2013 OBJECTIVES: This study sought to determine if nesiritide increases diuresis in congestive heart failure patients. BACKGROUND: In the ASCEND-HF (Acute Study of Clinical Effectiveness of Nesiritide and Decompensated Heart Failure), 7,141 patients hospitalize ... Full text Link to item Cite

Dabigatran for periprocedural anticoagulation following radiofrequency ablation for atrial fibrillation: a meta-analysis of observational studies.

Journal Article J Interv Card Electrophysiol · September 2013 PURPOSE: Dabigatran is approved for prevention of stroke or systemic embolism in patients with nonvalvular atrial fibrillation (AF). The safety and effectiveness of periprocedural dabigatran in ablation for AF are unknown. METHODS: We performed a meta-anal ... Full text Link to item Cite

Risk of acute thromboembolic events with oral contraceptive use: a systematic review and meta-analysis.

Journal Article Obstet Gynecol · August 2013 OBJECTIVE: To estimate the risk of venous thromboembolism, stroke, or myocardial infarction (MI) associated with the use of oral contraceptive pills (OCPs) and to describe how these risks vary by dose or formulation. DATA SOURCES: We searched PubMed, Embas ... Full text Link to item Cite

Oral contraceptive pills as primary prevention for ovarian cancer: a systematic review and meta-analysis.

Journal Article Obstet Gynecol · July 2013 OBJECTIVE: To estimate the overall reduction in ovarian cancer risk associated with the use of oral contraceptive pills (OCPs) and whether reduction in risk is affected by specifics of OCP use, such as formulation or duration of use. DATA SOURCES: We searc ... Full text Link to item Cite

Oral contraceptive use for the primary prevention of ovarian cancer.

Journal Article Evid Rep Technol Assess (Full Rep) · June 2013 OBJECTIVE: To estimate the overall balance of harms and benefits from the potential use of oral contraceptives (OCs) for the primary prevention of ovarian cancer DATA SOURCES: We searched PubMed®, Embase®, the Cochrane Database of Systematic Reviews, and C ... Link to item Cite

Methods of creatine kinase-MB analysis to predict mortality in patients with myocardial infarction treated with reperfusion therapy.

Journal Article Trials · May 2, 2013 BACKGROUND: Larger infarct size measured by creatine kinase (CK)-MB release is associated with higher mortality and has been used as an important surrogate endpoint in the evaluation of new treatments for ST-segment elevation myocardial infarction (STEMI). ... Full text Open Access Link to item Cite

Incorporation of bleeding as an element of the composite end point in clinical trials of antithrombotic therapies in patients with non-ST-segment elevation acute coronary syndrome: validity, pitfalls, and future approaches.

Journal Article Am Heart J · May 2013 With the large number of antithrombotic therapies available and under investigation for the treatment of non-ST-segment elevation acute coronary syndromes (NSTE ACS), practice guidelines now stress the importance of selecting an antithrombotic strategy acc ... Full text Link to item Cite

Predictors of early dyspnoea relief in acute heart failure and the association with 30-day outcomes: findings from ASCEND-HF.

Journal Article Eur J Heart Fail · April 2013 AIMS: To examine the characteristics associated with early dyspnoea relief during acute heart failure (HF) hospitalization, and its association with 30-day outcomes. METHODS AND RESULTS: ASCEND-HF was a randomized trial of nesiritide vs. placebo in 7141 pa ... Full text Link to item Cite

Would tirofiban have been shown non-inferior to abciximab had the TENACITY trial not been terminated for financial reasons?

Journal Article J Interv Cardiol · April 2013 OBJECTIVES: To investigate whether tirofiban would have been non-inferior to abciximab had the trial completed enrollment and place the termination of this trial in a broader research ethics context. BACKGROUND: TENACITY was terminated by the sponsor for f ... Full text Link to item Cite

A Heuristic Bayesian Approach to Knowledge Acquisition: Application to Analysis of Tissue-Type Plasminogen Activator

Conference · March 27, 2013 This paper describes a heuristic Bayesian method for computing probability distributions from experimental data, based upon the multivariate normal form of the influence diagram. An example illustrates its use in medical technology assessment. This approac ... Link to item Cite

HYPOTENSION IN ACUTE DECOMPENSATED HEART FAILURE: FINDINGS FROM ASCEND-HF

Conference Journal of the American College of Cardiology · March 2013 Full text Cite

The patient centered medical home. A systematic review.

Journal Article Ann Intern Med · February 5, 2013 BACKGROUND: The patient-centered medical home (PCMH) describes mechanisms for organizing primary care to provide high quality care across the full range of individuals' health care needs.It is being widely implemented by provider organizations and third pa ... Full text Link to item Cite

Is cardiac resynchronization therapy an antiarrhythmic therapy for atrial fibrillation? A systematic review and meta-analysis.

Journal Article Curr Cardiol Rep · February 2013 The impact of cardiac resynchronization therapy (CRT) on atrial fibrillation (AF) burden is poorly characterized. To assess the influence of CRT on AF, we performed a systematic literature search in MEDLINE using the MeSH headings "cardiac resynchronizatio ... Full text Link to item Cite

Risk of acute thromboembolic events with oral contraceptive use: a systematic review and meta-analysis.

Journal Article Obstetrics and gynecology · January 1, 2013 To estimate the risk of venous thromboembolism, stroke, or myocardial infarction (MI) associated with the use of oral contraceptive pills (OCPs) and to describe how these risks vary by dose or formulation. We searched PubMed, Embase, the Cochrane Database ... Cite

Assessment and Management of Chronic Cough.

Journal Article AHRQ Comparative Effectiveness Reviews · January 2013 Cite

Quality of anticoagulation with warfarin in patients with nonvalvular atrial fibrillation in the community setting.

Journal Article J Electrocardiol · 2013 BACKGROUND: The benefit of oral anticoagulation therapy with warfarin for stroke prevention in atrial fibrillation (AF) is directly dependent on the quality of anticoagulation (QoA), which in the US is provided predominantly in the community setting. With ... Full text Link to item Cite

Troponin I in acute decompensated heart failure: insights from the ASCEND-HF study.

Journal Article Eur J Heart Fail · November 2012 AIMS: We examined the prognostic importance of cardiac troponin I (cTnI) in a cohort of patients enrolled in the ASCEND-HF study of nesiritide in acute decompensated heart failure (ADHF). Circulating troponins are a prognostic marker in patients with ADHF. ... Full text Link to item Cite

The study of LoSmapimod treatment on inflammation and InfarCtSizE (SOLSTICE): design and rationale.

Journal Article Am Heart J · November 2012 The p38 mitogen-activated protein kinase (MAPK) is a nexus point in inflammation, sensing, and stimulating cytokine production and driving cell migration and death. In acute coronary syndromes, p38MAPK inhibition could stabilize ruptured atherosclerotic pl ... Full text Link to item Cite

Effect of clinical decision-support systems: a systematic review.

Journal Article Ann Intern Med · July 3, 2012 BACKGROUND: Despite increasing emphasis on the role of clinical decision-support systems (CDSSs) for improving care and reducing costs, evidence to support widespread use is lacking. PURPOSE: To evaluate the effect of CDSSs on clinical outcomes, health car ... Full text Link to item Cite

Closing the quality gap: revisiting the state of the science (vol. 2: the patient-centered medical home).

Journal Article Evid Rep Technol Assess (Full Rep) · July 2012 OBJECTIVES: As part of the Closing the Quality Gap: Revisiting the State of the Science series of the Agency for Healthcare Research and Quality (AHRQ), this systematic review sought to identify completed and ongoing evaluations of the comprehensive patien ... Link to item Cite

Updated report on comparative effectiveness of ACE inhibitors, ARBs, and direct renin inhibitors for patients with essential hypertension: much more data, little new information.

Journal Article J Gen Intern Med · June 2012 OBJECTIVES: A 2007 systematic review compared angiotensin-converting enzyme (ACE) inhibitors and angiotensin II receptor blockers (ARBs) in patients with hypertension. Direct renin inhibitors (DRIs) have since been introduced, and significant new research ... Full text Link to item Cite

Effect of Clinical Decision-Support Systems: A Systematic Review.

Journal Article Annals of internal medicine · April 2012 Background: Despite increasing emphasis on the role of clinical decision-support systems (CDSSs) for improving care and reducing costs, evidence to support widespread use is lacking. Purpose: To evaluate the effect of CDSSs on clinical outcomes, health car ... Full text Cite

Enabling health care decisionmaking through clinical decision support and knowledge management.

Journal Article Evid Rep Technol Assess (Full Rep) · April 2012 OBJECTIVES: To catalogue study designs used to assess the clinical effectiveness of CDSSs and KMSs, to identify features that impact the success of CDSSs/KMSs, to document the impact of CDSSs/KMSs on outcomes, and to identify knowledge types that can be in ... Link to item Cite

Clinical data simplified.

Journal Article J Neurosurg · February 2012 Full text Link to item Cite

Effect of nesiritide in patients with acute decompensated heart failure.

Journal Article N Engl J Med · July 7, 2011 BACKGROUND: Nesiritide is approved in the United States for early relief of dyspnea in patients with acute heart failure. Previous meta-analyses have raised questions regarding renal toxicity and the mortality associated with this agent. METHODS: We random ... Full text Link to item Cite

Upstream use of small-molecule glycoprotein iib/iiia inhibitors in patients with non-ST-segment elevation acute coronary syndromes: a systematic overview of randomized clinical trials.

Journal Article Circ Cardiovasc Qual Outcomes · July 2011 BACKGROUND: The use of upstream small-molecule glycoprotein (GP) IIb/IIIa inhibitors in non-ST-segment elevation acute coronary syndromes (NSTE ACS) has been studied in multiple randomized clinical trials. We systematically reviewed the effect of upstream ... Full text Link to item Cite

Intravenous erythropoietin in patients with ST-segment elevation myocardial infarction: REVEAL: a randomized controlled trial.

Journal Article JAMA · May 11, 2011 CONTEXT: Acute ST-segment elevation myocardial infarction (STEMI) is a leading cause of morbidity and mortality. In experimental models of MI, erythropoietin reduces infarct size and improves left ventricular (LV) function. OBJECTIVE: To evaluate the safet ... Full text Link to item Cite

Association of myocardial enzyme elevation and survival following coronary artery bypass graft surgery.

Journal Article JAMA · February 9, 2011 CONTEXT: Several small studies have suggested that cardiac enzyme elevation in the 24 hours following coronary artery bypass graft (CABG) surgery is associated with worse prognosis, but a definitive study is not available. Also, the long-term prognostic im ... Full text Link to item Cite

Use of implantable cardioverter-defibrillators for primary prevention in older patients: a systematic literature review and meta-analysis.

Journal Article Cardiol J · 2011 BACKGROUND: Randomized clinical trials (RCTs) have demonstrated the efficacy of implantable cardioverter-defibrillators (ICDs) in reducing sudden cardiac death (SCD) in specific patient populations. However, patients ≥ 65 years were under-represented in th ... Full text Link to item Cite

Surgical Maze procedure as a treatment for atrial fibrillation: a meta-analysis of randomized controlled trials.

Journal Article Cardiovasc Ther · October 2010 Surgical or modified Maze procedures have been promoted to treat atrial fibrillation (AF); however, few randomized controlled clinical trials (RCTs) examine their outcomes. The purpose of this meta-analysis is to compare the efficacy of surgical Maze proce ... Full text Link to item Cite

Natural killer cell-enriched donor lymphocyte infusions from A 3-6/6 HLA matched family member following nonmyeloablative allogeneic stem cell transplantation.

Journal Article Biol Blood Marrow Transplant · August 2010 Infusing natural killer (NK) cells following transplantation may allow less infections and relapse with little risk of acute graft-versus-host disease (aGVHD). We delivered 51 total NK cell-enriched donor lymphocyte infusions (DLIs) to 30 patients followin ... Full text Link to item Cite

Correction

Journal Article Journal of the American College of Cardiology · May 2010 Full text Cite

Triage after hospitalization with advanced heart failure: the ESCAPE (Evaluation Study of Congestive Heart Failure and Pulmonary Artery Catheterization Effectiveness) risk model and discharge score.

Journal Article J Am Coll Cardiol · March 2, 2010 OBJECTIVES: Identifying high-risk heart failure (HF) patients at hospital discharge may allow more effective triage to management strategies. BACKGROUND: Heart failure severity at presentation predicts outcomes, but the prognostic importance of clinical st ... Full text Link to item Cite

Pulmonary vein isolation for the maintenance of sinus rhythm in patients with atrial fibrillation: a meta-analysis of randomized, controlled trials.

Journal Article Circ Arrhythm Electrophysiol · December 2009 BACKGROUND: Catheter ablation is an established yet evolving nonpharmacologic intervention for the maintenance of sinus rhythm in patients with atrial fibrillation (AF). The efficacy and safety of pulmonary vein isolation (PVI) compared with medical therap ... Full text Link to item Cite

Transforming verbal counts in reports of qualitative descriptive studies into numbers.

Journal Article West J Nurs Res · November 2009 Reports of qualitative studies typically do not offer much information on the numbers of respondents linked to any one finding. This information may be especially useful in reports of basic, or minimally interpretive, qualitative descriptive studies focuse ... Full text Link to item Cite

Comparative efficacy of dronedarone and amiodarone for the maintenance of sinus rhythm in patients with atrial fibrillation.

Journal Article J Am Coll Cardiol · September 15, 2009 OBJECTIVES: We sought to compare the efficacy and safety of dronedarone versus amiodarone for the prevention of recurrent atrial fibrillation (AF). BACKGROUND: Dronedarone is a noniodinated amiodarone congener developed to maintain sinus rhythm. Few data a ... Full text Link to item Cite

Biomarker-guided therapy in chronic heart failure: a meta-analysis of randomized controlled trials.

Journal Article Am Heart J · September 2009 BACKGROUND: Measurement of circulating natriuretic peptides has been shown to play an important role in diagnosis and prognosis in patients with chronic heart failure. Whether serial natriuretic peptide measurements to aid in the titration of therapy can i ... Full text Link to item Cite

Acute in-vivo evaluation of bleeding with Gelfoam plus saline and Gelfoam plus human thrombin using a liver square lesion model in swine.

Journal Article J Thromb Thrombolysis · July 2009 BACKGROUND: Management of post-operative bleeding has historically used topical bovine thrombin. However, possible harm through activation of coagulation inhibitors has encouraged investigation with other hemostatic agents. This study utilized a novel ordi ... Full text Link to item Cite

Biomarker Guided Therapy in Chronic Heart Failure: A Meta-Analysis of Randomized Controlled Trials

Journal Article JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY · March 10, 2009 Link to item Cite

Rationale and design of the Acute Study of Clinical Effectiveness of Nesiritide in Decompensated Heart Failure Trial (ASCEND-HF).

Journal Article Am Heart J · February 2009 BACKGROUND: Acute decompensated heart failure (ADHF) is a major public health burden with significant mortality and morbidity. Nesiritide is a recombinantly produced intravenous formulation of human B-type natriuretic peptide that promotes vasodilation and ... Full text Link to item Cite

Association of weight change with subsequent outcomes in patients hospitalized with acute decompensated heart failure.

Journal Article Am J Cardiol · January 1, 2009 The association of weight loss achieved through various decongestive strategies with clinical outcomes in patients with acute decompensated heart failure (HF) is not well described. The aim of this study was to determine the relation between weight change ... Full text Link to item Cite

Racial differences in blood pressure response to angiotensin-converting enzyme inhibitors in children: a meta-analysis.

Journal Article Clin Pharmacol Ther · September 2008 Angiotensin-converting enzyme (ACE) inhibitors are frequently used to treat hypertension in children.(1) ACE inhibitors alter the balance between the vasoconstrictive, salt-retentive, and cardiac hypertrophic properties of angiotensin II and the vasodilato ... Full text Link to item Cite

A clinical practice guideline for treating tobacco use and dependence: 2008 update. A U.S. Public Health Service report.

Journal Article Am J Prev Med · August 2008 OBJECTIVE: To summarize the U.S. Public Health Service guideline Treating Tobacco Use and Dependence: 2008 Update, which provides recommendations for clinical interventions and system changes to promote the treatment of tobacco dependence. PARTICIPANTS: An ... Full text Link to item Cite

A novel bioresorbable polymer paclitaxel-eluting stent for the treatment of single and multivessel coronary disease: primary results of the COSTAR (Cobalt Chromium Stent With Antiproliferative for Restenosis) II study.

Journal Article J Am Coll Cardiol · April 22, 2008 OBJECTIVES: The aim was to compare safety and effectiveness of the CoStar drug-eluting stent (DES) (Conor MedSystems, Menlo Park, California) with those of the Taxus DES (Boston Scientific, Maple Grove, Minnesota) in de novo single- and multivessel percuta ... Full text Link to item Cite

Efficacy and safety of pyridoxal 5'-phosphate (MC-1) in high-risk patients undergoing coronary artery bypass graft surgery: the MEND-CABG II randomized clinical trial.

Journal Article JAMA · April 16, 2008 CONTEXT: Coronary artery bypass graft (CABG) surgery is frequently performed and effective; however, perioperative complications related to ischemia-reperfusion injury, including myocardial infarction (MI), remain common and result in significant morbidity ... Full text Link to item Cite

Pediatric antihypertensive trial failures: analysis of end points and dose range.

Journal Article Hypertension · April 2008 Historically, drugs prescribed for children have not been studied in pediatric populations. Since 1997, however, a 6-month extension of marketing rights is granted if manufacturers conduct Food and Drug Administration-defined pediatric trials. In nearly ha ... Full text Link to item Cite

A randomized, double-blind, placebo-controlled, multicenter study to evaluate the cardioprotective effects of MC-1 in patients undergoing high-risk coronary artery bypass graft surgery: MC-1 to Eliminate Necrosis and Damage in Coronary Artery Bypass Graft Surgery Trial (MEND-CABG) II--study design and rationale.

Journal Article Am Heart J · April 2008 BACKGROUND: Coronary artery bypass graft (CABG) surgery is effective in relieving angina and improving survival and quality of life in patients with obstructive coronary artery disease; however, recurrent angina, myocardial infarction, neurological injury, ... Full text Link to item Cite

Cardiorenal interactions: insights from the ESCAPE trial.

Journal Article J Am Coll Cardiol · April 1, 2008 OBJECTIVES: We examined the ESCAPE (Evaluation Study of Congestive Heart Failure and Pulmonary Artery Catheterization Effectiveness) database to understand the impact and pathophysiology of renal dysfunction in patients hospitalized with advanced decompens ... Full text Link to item Cite

Delivering heart failure disease management in 3 tertiary care centers: key clinical components and venues of care.

Journal Article Am Heart J · April 2008 BACKGROUND: Little data exist to assist to help those organizing and managing heart failure (HF) disease management (DM) programs. We aimed to describe the intensity of outpatient HF care (clinic visits and telephone calls) and medical and nonpharmacologic ... Full text Link to item Cite

Making Sense of Qualitative and Quantitative Findings in Mixed Research Synthesis Studies.

Journal Article Field methods · 2008 The synthesis of qualitative and quantitative research findings is increasingly promoted, but many of the conceptual and methodological issues it raises have yet to be fully understood and resolved. In this article, we describe how we handled issues encoun ... Full text Link to item Cite

Effectiveness of Glycerol Mono-oleate as a Biosealant.

Journal Article J Invasive Cardiol · January 2008 BACKGROUND: The number of femoral artery catheterizations will increase over the next decade to more than 9 million worldwide. Accordingly, a new era of access site management with vascular closure techniques utilizing biologics are being developed and imp ... Link to item Cite

INTEGRATING QUALITATIVE AND QUANTITATIVE RESEARCH FINDINGS

Journal Article ANNALS OF BEHAVIORAL MEDICINE · December 1, 2007 Link to item Cite

Rapid assay brain natriuretic peptide and troponin I in patients hospitalized with decompensated heart failure (from the Evaluation Study of Congestive Heart Failure and Pulmonary Artery Catheterization Effectiveness Trial).

Journal Article Am J Cardiol · November 1, 2007 Rapid-assay biomarkers may predict outcomes in patients with decompensated heart failure (HF). This study assessed whether rapid-assay B-type natriuretic peptide (BNP) and troponin I predicts length of stay and mortality and correlates with pulmonary arter ... Full text Link to item Cite

Relation between dose of loop diuretics and outcomes in a heart failure population: results of the ESCAPE trial.

Journal Article Eur J Heart Fail · October 2007 BACKGROUND: We examined the relation of maximal in-hospital diuretic dose to weight loss, changes in renal function, and mortality in hospitalised heart failure (HF) patients. METHODS: In ESCAPE, 395 patients received diuretics in-hospital. Weight was meas ... Full text Link to item Cite

Physical examination tests for assessing a torn meniscus in the knee: a systematic review with meta-analysis.

Journal Article J Orthop Sports Phys Ther · September 2007 STUDY DESIGN: Systematic review and meta-analysis. OBJECTIVES: To identify, analyze, and synthesize the literature to determine which physical examination tests, if any, accurately diagnose a torn tibial meniscus. BACKGROUND: Knee pain has a lifetime preva ... Full text Link to item Cite

In or out? Methodological considerations for including and excluding findings from a meta-analysis of predictors of antiretroviral adherence in HIV-positive women.

Journal Article J Adv Nurs · July 2007 AIM: This paper is a discussion detailing the decisions concerning whether to include or exclude findings from a meta-analysis of report of quantitative studies of antiretroviral adherence in HIV-positive women. BACKGROUND: Publication constraints and the ... Full text Link to item Cite

Relationship between interdialytic weight gain and blood pressure among prevalent hemodialysis patients.

Journal Article Am J Kidney Dis · July 2007 BACKGROUND: Hypertension is common in hemodialysis patients; however, the relationship between interdialytic weight gain (IDWG) and blood pressure (BP) is incompletely characterized. This study seeks to define the relationship between IDWG and BP in preval ... Full text Link to item Cite

Effects of pyridoxal-5'-phosphate (MC-1) in patients undergoing high-risk coronary artery bypass surgery: results of the MEND-CABG randomized study.

Journal Article J Thorac Cardiovasc Surg · June 2007 OBJECTIVE: Coronary artery bypass graft surgery remains associated with significant postoperative cardiovascular morbidity and mortality in high-risk patients. MC-1 (pyridoxal-5'-phosphate monohydrate) inhibits purinergic receptors and intracellular influx ... Full text Link to item Cite

The Cobalt chromium STent with Antiproliferative for Restenosis II (COSTAR II) trial study design: advancing the active-control evaluation of second-generation drug-eluting stents.

Journal Article Am Heart J · May 2007 BACKGROUND: Randomized clinical trials have demonstrated the superiority of drug-eluting stents (DESs) compared with bare-metal stents in reducing the need for revascularization and major adverse cardiac events (MACEs) in low-risk patients with single-vess ... Full text Link to item Cite

Association of intradialytic blood pressure changes with hospitalization and mortality rates in prevalent ESRD patients.

Journal Article Kidney Int · March 2007 The relationship between blood pressure (BP) and clinical outcomes among hemodialysis patients is complex and incompletely understood. This study sought to assess the relationship between blood pressure changes with hemodialysis and clinical outcomes durin ... Full text Link to item Cite

Prediction of rehospitalization and death in severe heart failure by physicians and nurses of the ESCAPE trial.

Journal Article J Card Fail · February 2007 BACKGROUND: The predictive accuracy of physician investigators and nurse coordinators in estimating the risk of rehospitalization and death was determined for 373 hospitalized patients with severe advanced heart failure enrolled in the Evaluation Study of ... Full text Link to item Cite

Tests for 2 × 2 tables in clinical trials

Journal Article Journal of Modern Applied Statistical Methods · January 1, 2007 Five standard tests are compared: chi-squared, Fisher's exact, Yates' correction, Fisher's exact mid-p, and Barnard's. Yates' is always inferior to Fisher's exact. Fisher's exact is so conservative that one should look for alternatives. For certain sample ... Full text Cite

Effect of pexelizumab on mortality in patients with acute myocardial infarction or undergoing coronary artery bypass surgery: a systematic overview.

Journal Article Am Heart J · August 2006 BACKGROUND: Recent trials evaluating the C5 complement inhibitor, pexelizumab, have shown that modulation of inflammation during ischemia/reperfusion in patients with acute myocardial infarction (MI) or undergoing coronary artery bypass graft (CABG) surger ... Full text Link to item Cite

The ESCAPE Discharge Risk Score: Don't Go Home without It

Conference Journal of Cardiac Failure · August 2006 Full text Cite

Can one assess whether missing data are missing at random in medical studies?

Journal Article Stat Methods Med Res · June 2006 For handling missing data, newer methods such as those based on multiple imputation are generally more accurate than older ones and entail weaker assumptions. Yet most do assume that data are missing at random (MAR). The issue of assessing whether the MAR ... Full text Link to item Cite

Effect of the novel direct factor Xa inhibitor DX-9065a on thrombin generation and inhibition among patients with stable atherosclerotic coronary artery disease.

Journal Article Thromb Res · 2006 Featured Publication INTRODUCTION: Thrombin, a pluripotential effector enzyme with prothrombotic, proinflammatory, and mitogenic properties, plays a pivotal role in the pathobiology and clinical expression of atherothrombotic coronary artery disease. Existing anticoagulant dru ... Full text Link to item Cite

Impact of the pulmonary artery catheter in critically ill patients: meta-analysis of randomized clinical trials.

Journal Article JAMA · October 5, 2005 Featured Publication CONTEXT: Randomized clinical trials (RCTs) evaluating the pulmonary artery catheter (PAC) have been limited by small sample size. Some nonrandomized studies suggest that PAC use is associated with increased morbidity and mortality. OBJECTIVE: To estimate t ... Full text Link to item Cite

Evaluation study of congestive heart failure and pulmonary artery catheterization effectiveness: the ESCAPE trial.

Journal Article JAMA · October 5, 2005 Featured Publication CONTEXT: Pulmonary artery catheters (PACs) have been used to guide therapy in multiple settings, but recent studies have raised concerns that PACs may lead to increased mortality in hospitalized patients. OBJECTIVE: To determine whether PAC use is safe and ... Full text Link to item Cite

The Pilot Randomized Study of Nesiritide Versus Dobutamine in Heart Failure (PRESERVD-HF).

Journal Article Am J Cardiol · September 19, 2005 Featured Publication Acute heart failure syndromes (AHFS) are related to several diseases affecting not only the heart but also the kidneys and blood vessels. Emerging evidence indicates that myocardial injury may also play a role in the pathophysiology of AHFS, as suggested b ... Full text Link to item Cite

Intradialytic blood volume monitoring in ambulatory hemodialysis patients: a randomized trial.

Journal Article J Am Soc Nephrol · July 2005 Featured Publication Complications related to inadequate volume management are common during hemodialysis. This trial tested the hypothesis that availability of an intradialytic blood volume monitoring (IBVM) device improves fluid removal, reducing morbidity. A six-center, ran ... Full text Link to item Cite

Diabetes-related knowledge, atherosclerotic risk factor control, and outcomes in acute coronary syndromes.

Journal Article Am J Cardiol · June 1, 2005 Featured Publication Patients who have diabetes mellitus have 2 times the incidence of an acute coronary syndrome (ACS) and 2 times the mortality rate after ACS compared with patients who do not have diabetes. Poor patient understanding of diabetes is believed to impede approp ... Full text Link to item Cite

Intensity and focus of heart failure disease management after hospital discharge.

Journal Article Am Heart J · April 2005 Featured Publication BACKGROUND: Although features of heart failure disease management programs are broadly outlined, little is known about which interventions are actually used in the outpatient setting or which patients are most likely to require interventions. METHODS AND R ... Full text Link to item Cite

A perspective on trials comparing enoxaparin and unfractionated heparin in the treatment of non-ST-elevation acute coronary syndromes.

Journal Article Am Heart J · April 2005 Featured Publication BACKGROUND: Non-ST-elevation (NSTE) acute coronary syndrome (ACS) is a serious, acute illness characterized by a high rate of death and morbid events, and antithrombin therapy is integral to its management. Contemporary guidelines from the American College ... Full text Link to item Cite

A systematic review of diabetes disease management programs.

Journal Article Am J Manag Care · April 2005 Featured Publication OBJECTIVE: To systematically evaluate and synthesize published evidence regarding the effect of disease management programs for patients with diabetes mellitus on processes and outcomes of care. STUDY DESIGN: Systematic literature review and meta-analysis. ... Link to item Cite

Metaanalysis and review of heart failure disease management randomized controlled clinical trials.

Journal Article Am Heart J · April 2005 Featured Publication BACKGROUND: The medical community has turned to disease management (DM) to bridge the gap between proven therapies and clinical practice for patients with heart failure (HF). The aim of this study was to assess the effectiveness of DM programs in reducing ... Full text Link to item Cite

Demographics, clinical characteristics, and outcomes of patients hospitalized for decompensated heart failure: observations from the IMPACT-HF registry.

Journal Article J Card Fail · April 2005 Featured Publication BACKGROUND: Hospitalizations for decompensated heart failure are frequent. The Initiation Management Pre-discharge Assessment of Carvedilol Heart Failure (IMPACT-HF) registry collected observational data in patients hospitalized for worsening heart failure ... Full text Link to item Cite

Prediction of rehospitalization and death in advanced heart failure patients by nurses and physicians

Conference JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY · February 1, 2005 Link to item Cite

Does disease management improve clinical and economic outcomes in patients with chronic diseases? A systematic review.

Journal Article Am J Med · August 1, 2004 Featured Publication PURPOSE: To assess the clinical and economic effects of disease management in patients with chronic diseases. METHODS: Electronic databases were searched for English-language articles from 1987 to 2001. Articles were included if they used a systematic appr ... Full text Link to item Cite

Safety and efficacy of enoxaparin vs unfractionated heparin in patients with non-ST-segment elevation acute coronary syndromes who receive tirofiban and aspirin: a randomized controlled trial.

Journal Article JAMA · July 7, 2004 Featured Publication CONTEXT: Enoxaparin or the combination of glycoprotein IIb/IIIa inhibitor tirofiban with unfractionated heparin independently have shown superior efficacy over unfractionated heparin alone in patients with non-ST-elevation acute coronary syndromes (ACS). I ... Full text Link to item Cite

Efficacy and bleeding complications among patients randomized to enoxaparin or unfractionated heparin for antithrombin therapy in non-ST-Segment elevation acute coronary syndromes: a systematic overview.

Journal Article JAMA · July 7, 2004 Featured Publication CONTEXT: Antithrombin therapy has become a guidelines-recommended standard of care in the treatment of acute coronary syndromes (ACS), but recent trials comparing use of enoxaparin and unfractionated heparin in ACS have yielded less robust efficacy and saf ... Full text Link to item Cite

Usefulness of an elevated troponin-I in predicting clinical events in patients admitted with acute heart failure and acute coronary syndrome (from the RITZ-4 trial).

Journal Article Am J Cardiol · June 1, 2004 Featured Publication The relation of cardiac troponin-I (cTnI) to clinical outcomes was examined in patients with decompensated heart failure and concomitant acute coronary syndrome enrolled into the Randomized Intravenous TeZosentan 4 (RITZ-4) study. RITZ-4 was a multicenter, ... Full text Link to item Cite

Predischarge initiation of carvedilol in patients hospitalized for decompensated heart failure: results of the Initiation Management Predischarge: Process for Assessment of Carvedilol Therapy in Heart Failure (IMPACT-HF) trial.

Journal Article J Am Coll Cardiol · May 5, 2004 Featured Publication OBJECTIVES: The Initiation Management Predischarge: Process for Assessment of Carvedilol Therapy in Heart Failure (IMPACT-HF) trial was an investigator-initiated study to evaluate if predischarge carvedilol initiation in stabilized patients hospitalized fo ... Full text Link to item Cite

Effect of angiotensin-converting enzyme inhibitors, beta blockers, statins, and aspirin on C-reactive protein levels in outpatients with heart failure.

Journal Article Am J Cardiol · March 15, 2004 Featured Publication C-reactive protein (CRP) levels were measured in a cohort of 96 outpatients with heart failure. Baseline angiotensin-converting enzyme inhibitor plus beta-blocker use were associated with lower levels of CRP; no relation was found between CRP levels and as ... Full text Link to item Cite

Improved clinical outcomes with abciximab therapy in acute myocardial infarction: a systematic overview of randomized clinical trials.

Journal Article Am Heart J · March 2004 Featured Publication BACKGROUND: Investigations of glycoprotein (GP) IIb/IIIa inhibition in primary percutaneous coronary intervention (PCI) have suggested the efficacy of abciximab in improving clinical and angiographic outcomes, but sample-size limitations and variability in ... Full text Link to item Cite

Feasibility of endovascular cooling as an adjunct to primary percutaneous coronary intervention (results of the LOWTEMP pilot study).

Journal Article Am J Cardiol · March 1, 2004 Featured Publication In a nonrandomized feasibility study of therapeutic hypothermia in acute myocardial infarction, 18 patients were treated with endovascular cooling (Alsius, Irvine, California) as adjunctive therapy to primary percutaneous coronary intervention to assess me ... Full text Link to item Cite

Implications of elevated cardiac troponin T in ambulatory patients with heart failure: a prospective analysis.

Journal Article Am Heart J · March 2004 Featured Publication BACKGROUND: Elevated concentrations of cardiac troponin T (TnT) have been reported in patients hospitalized for decompensated heart failure (HF). We assessed whether elevated TnT levels are associated with the severity, etiology, and prognosis of HF in sta ... Full text Link to item Cite

Differential treatment benefit of platelet glycoprotein IIb/IIIa inhibition with percutaneous coronary intervention versus medical therapy for acute coronary syndromes: exploration of methods.

Journal Article Circulation · February 10, 2004 Featured Publication BACKGROUND: Although many believe that platelet glycoprotein IIb/IIIa inhibitors should be used only in acute coronary syndrome patients undergoing percutaneous coronary intervention, supporting data from randomized clinical trials are tenuous. The assumpt ... Full text Link to item Cite

Initial experience with factor-Xa inhibition in percutaneous coronary intervention: the XaNADU-PCI Pilot.

Journal Article J Thromb Haemost · February 2004 Featured Publication BACKGROUND: Direct factor (F)Xa inhibition is an attractive method to limit thrombotic complications during percutaneous coronary intervention (PCI). OBJECTIVES: To investigate drug levels achieved, effect on coagulation markers, and preliminary efficacy a ... Full text Link to item Cite

Effectiveness of disease management programs in depression: a systematic review.

Journal Article Am J Psychiatry · December 2003 Featured Publication OBJECTIVE: The authors systematically evaluated the published evidence to assess the effectiveness of disease management programs in depression. METHOD: English-language articles on depression were identified through a MEDLINE search for the period from Ja ... Full text Link to item Cite

Revascularization in patients with coronary artery disease, left ventricular dysfunction, and viability: a meta-analysis.

Journal Article Am Heart J · October 2003 Featured Publication BACKGROUND: The effects of viability status and treatment allocation on long-term mortality in patients with left ventricular dysfunction and coronary artery disease have not been determined. Several observational studies with significant limitations have ... Full text Link to item Cite

Meta-analysis of survival with platelet glycoprotein IIb/IIIa antagonists for percutaneous coronary interventions.

Journal Article Am J Cardiol · September 15, 2003 Featured Publication We performed a cumulative meta-analysis of available studies to evaluate the effect of intravenous platelet glycoprotein (GP) IIb/IIIa antagonists on survival at 30 days and 6 months after percutaneous coronary intervention (PCI). Compounds that block the ... Full text Link to item Cite

Reduction of myocardial ischemic injury following coronary intervention (the MC-1 to Eliminate Necrosis and Damage trial).

Journal Article Am J Cardiol · September 15, 2003 Featured Publication Myocardial ischemic injury complicating acute myocardial infarction (AMI) and coronary revascularization procedures remains an unresolved clinical dilemma. In preclinical studies, treatment with pyridoxal-5'-phosphate monohydrate (MC-1), a vitamin B6 metab ... Full text Link to item Cite

Evaluation of an infrared/radiofrequency equipment-tracking system in a tertiary care hospital.

Journal Article J Med Syst · August 2003 Featured Publication Optimal management of assets in large hospitals is important to both cost control and patient care. A prospective controlled evaluation was conducted to determine whether an asset-tracking system using combined radiofrequency and infrared signals could inc ... Full text Link to item Cite

Power calculations for large multi-arm placebo-controlled studies of dichotomous outcomes.

Journal Article Stat Med · June 30, 2003 Featured Publication Several statistical methods can be used to test for differences in placebo-controlled dichotomous multi-arm studies. These tests include linear and quadratic trends, Dunnett's test, Hochberg's test, and the overall chi-square test. We computed the power of ... Full text Link to item Cite

Tocolytic treatment for the management of preterm labor: a review of the evidence.

Journal Article Am J Obstet Gynecol · June 2003 Featured Publication OBJECTIVE: Preterm labor is often a prelude to early births and the significant attendant burden of infant morbidity and mortality. Treatment consists of bedrest, hydration, pharmacologic interventions, and combinations of these. We systematically reviewed ... Full text Link to item Cite

Tezosentan in patients with acute heart failure and acute coronary syndromes: results of the Randomized Intravenous TeZosentan Study (RITZ-4).

Journal Article J Am Coll Cardiol · May 7, 2003 Featured Publication OBJECTIVES: We sought to determine the effect of tezosentan in patients with acute decompensated heart failure (HF) associated with acute coronary syndrome (ACS). BACKGROUND: Tezosentan is a dual endothelin receptor antagonist that has been shown to improv ... Full text Link to item Cite

Prognostic value of isolated troponin elevation across the spectrum of chest pain syndromes.

Journal Article Am J Cardiol · April 15, 2003 Featured Publication The risk of death or recurrent myocardial infarction (MI) in patients with chest pain and baseline isolated troponin elevation is unclear. To determine the early and short-term risk of death or MI associated with isolated troponin elevation across a spectr ... Full text Link to item Cite

Troponin T and quantitative ST-segment depression offer complementary prognostic information in the risk stratification of acute coronary syndrome patients.

Journal Article J Am Coll Cardiol · February 5, 2003 Featured Publication OBJECTIVES: Our primary objective was to examine the prognostic relationship between baseline quantitative ST-segment depression (ST) and cardiac troponin T (cTnT) elevation. The secondary objectives were to: 1) examine whether ST provided additional insig ... Full text Link to item Cite

Time-based risk assessment after myocardial infarction. Implications for timing of discharge and applications to medical decision-making.

Journal Article Eur Heart J · January 2003 Featured Publication AIMS: We evaluated timing of adverse cardiac events after thrombolysis to guide length of stay after ST-segment elevation myocardial infarction. METHODS AND RESULTS: Kaplan-Meier survival curves described timing of major postinfarction complications in 410 ... Full text Link to item Cite

Evaluation of a tool to categorize patients by reading literacy and computer skill to facilitate the computer-administered patient interview.

Journal Article AMIA Annu Symp Proc · 2003 Featured Publication Past efforts to collect clinical information directly from patients using computers have had limited utility because these efforts required users to be literate and facile with the computerized information collecting system. In this paper we describe the c ... Link to item Cite

Coronary artery pattern and outcome of arterial switch operation for transposition of the great arteries: a meta-analysis.

Journal Article Circulation · November 12, 2002 Featured Publication BACKGROUND: Prior studies of coronary pattern and outcome after arterial switch operation (ASO) for transposition of the great arteries (TGA) have been hindered by limited statistical power. This meta-analysis assesses the effect of coronary anatomy on pos ... Full text Link to item Cite

Interventions used in disease management programmes for patients with chronic illness-which ones work? Meta-analysis of published reports.

Journal Article BMJ · October 26, 2002 Featured Publication OBJECTIVE: To systematically evaluate the published evidence regarding the characteristics and effectiveness of disease management programmes. DESIGN: Meta-analysis. DATA SOURCES: Computerised databases for English language articles during 1987-2001. STUDY ... Full text Link to item Cite

Seeking the optimal aspirin dose in acute coronary syndromes.

Journal Article Am J Cardiol · September 15, 2002 Featured Publication Full text Link to item Cite

Benefits of smoking cessation for longevity. (vol 92, pg 990, 2002)

Journal Article AMERICAN JOURNAL OF PUBLIC HEALTH · September 1, 2002 Link to item Cite

Role of target vessel size and body surface area on outcomes after percutaneous coronary interventions in women.

Journal Article Am Heart J · August 2002 Featured Publication BACKGROUND: Women have higher mortality rates than men after coronary angioplasty. Differences in target vessel size may partially account for these differences. We set out to explore the effects of sex, body surface area (BSA), and target coronary vessel ... Full text Link to item Cite

Systematic review and meta-analysis of monotherapy compared with combined androgen blockade for patients with advanced prostate carcinoma.

Journal Article Cancer · July 15, 2002 Featured Publication BACKGROUND: The current systematic review and meta-analysis compared monotherapy and combined androgen blockade in the treatment of men with advanced prostate carcinoma. Outcomes of interest included overall, cancer specific, and progression-free survival; ... Full text Link to item Cite

Prognostic significance of elevated troponin I after percutaneous coronary intervention.

Journal Article J Am Coll Cardiol · June 5, 2002 Featured Publication OBJECTIVES: We sought to assess the incidence and clinical significance of elevated cardiac troponin I (cTnI) after percutaneous coronary intervention (PCI). BACKGROUND: Elevated creatine kinase-MB (CK-MB) is prognostically important after PCI, but the pro ... Full text Link to item Cite

The failure of orally administered glycoprotein IIb/IIIa inhibitors to prevent recurrent cardiac events.

Journal Article Am J Med · June 1, 2002 Featured Publication PURPOSE: Despite the success of intravenous glycoprotein IIb/IIIa antagonists, oral formulations have failed to show benefit and have been associated with increased mortality. To understand these findings, we performed a meta-analysis of results from four ... Full text Link to item Cite

Benefits of smoking cessation for longevity.

Journal Article Am J Public Health · June 2002 Featured Publication OBJECTIVES: This study determined the life extension obtained from stopping smoking at various ages. METHODS: We estimated the relation between smoking and mortality among 877,243 respondents to the Cancer Prevention Study II. These estimates were applied ... Full text Link to item Cite

Evaluation of platelets in heart failure: is platelet activity related to etiology, functional class, or clinical outcomes?

Journal Article Am Heart J · June 2002 Featured Publication OBJECTIVES: We sought to determine whether platelet activity in patients with heart failure is related to an ischemic versus nonischemic etiologic condition, clinical disease severity, or adverse clinical outcomes. BACKGROUND: Platelet activity may affect ... Full text Link to item Cite

Dissociation between hemodynamic changes and symptom improvement in patients with advanced congestive heart failure.

Journal Article Eur J Heart Fail · June 2002 Featured Publication BACKGROUND: Changes in hemodynamic measures often serve as surrogate end points in efficacy trials for advanced heart failure, although there are few objective data to support this practice. AIMS: We compared changes in hemodynamic variables vs. changes in ... Full text Link to item Cite

First experience with direct factor Xa inhibition in patients with stable coronary disease: a pharmacokinetic and pharmacodynamic evaluation.

Journal Article Circulation · May 21, 2002 Featured Publication BACKGROUND: Thrombin generation is critical to the formation of an arterial thrombus after rupture of an atherosclerotic plaque. In patients with stable coronary disease receiving standard medical therapy, we evaluated the pharmacokinetics, pharmacodynamic ... Full text Link to item Cite

Antibiotic therapy for the treatment of preterm labor: a review of the evidence.

Journal Article Am J Obstet Gynecol · March 2002 Featured Publication OBJECTIVE: The purpose of this study was to evaluate the evidence regarding antibiotics for the treatment of preterm labor. STUDY DESIGN: Through dual review, we abstracted study design and masking, definitions of preterm labor and pregnancy outcome, patie ... Full text Link to item Cite

A randomized, placebo-controlled trial of enoxaparin after high-risk coronary stenting: the ATLAST trial.

Journal Article J Am Coll Cardiol · November 15, 2001 Featured Publication OBJECTIVES: We performed a multicenter, double-blind placebo-controlled trial to examine the efficacy and safety of enoxaparin in patients at high risk for stent thrombosis (ST). BACKGROUND: The optimal antithrombotic regimen for such patients is unknown. ... Full text Link to item Cite

Prognostic usefulness of the six-minute walk in patients with advanced congestive heart failure secondary to ischemic or nonischemic cardiomyopathy.

Journal Article Am J Cardiol · November 1, 2001 Featured Publication Clinicians have relied on history and results from physical examinations to guide treatment of patients with advanced congestive heart failure, but these results may not reflect disease severity or hemodynamic status. We assessed how the distance walked in ... Full text Link to item Cite

Relationship between transferrin saturation and iron stores in the African American and US Caucasian populations: analysis of data from the third National Health and Nutrition Examination Survey.

Journal Article Blood · October 15, 2001 Featured Publication In previous analyses of transferrin saturation data in African Americans and Caucasians from the second National Health and Nutrition Examination Survey (NHANES II), subpopulations were found consistent with population genetics for common loci that influen ... Full text Link to item Cite

Short-term trials and long-term effects.

Journal Article Science · September 28, 2001 Full text Link to item Cite

Short-term trials and long-term effects - Response

Journal Article SCIENCE · September 28, 2001 Link to item Cite

Epoetin treatment of anemia associated with cancer therapy: a systematic review and meta-analysis of controlled clinical trials.

Journal Article J Natl Cancer Inst · August 15, 2001 Featured Publication Epoetin treatment offers an attractive but costly alternative to red blood cell transfusion for managing anemia associated with cancer therapy. The goal of this review is to facilitate more efficient use of epoetin by 1) quantifying the effects of epoetin ... Full text Link to item Cite

Assessing the clinical and economic burden of coronary artery disease: 1986-1998.

Journal Article Med Care · August 2001 Featured Publication BACKGROUND: The acute phase of coronary artery disease (CAD) is dramatic and receives much attention because of its high mortality and associated treatment cost. However, the acute phase typically resolves within 30 days whereas CAD is a chronic disease, w ... Full text Link to item Cite

Benefit of glycoprotein IIb/IIIa inhibition in patients with acute coronary syndromes and troponin t-positive status: the paragon-B troponin T substudy.

Journal Article Circulation · June 19, 2001 Featured Publication BACKGROUND: Troponin T (TnT) is valuable for short- and long-term risk stratification of patients with acute coronary syndromes (ACS). It also may predict which ACS patients will benefit from glycoprotein (GP) IIb/IIIa blockade. METHODS AND RESULTS: We pro ... Full text Link to item Cite

Medicine. Placebo-controls in short-term clinical trials of hypertension.

Journal Article Science · June 15, 2001 Featured Publication Full text Link to item Cite

Hemodynamic profiles of advanced heart failure: association with clinical characteristics and long-term outcomes.

Journal Article J Card Fail · June 2001 Featured Publication BACKGROUND: Classifying patients with advanced congestive heart failure (CHF) by baseline measures of congestion and perfusion has been used to estimate hemodynamic status and to select and titrate therapy. We describe clinical characteristics of 4 hemodyn ... Full text Link to item Cite

Platelet glycoprotein IIb/IIIa integrin blockade with eptifibatide in coronary stent intervention: the ESPRIT trial: a randomized controlled trial.

Journal Article JAMA · May 16, 2001 Featured Publication CONTEXT: The Enhanced Suppression of the Platelet IIb/IIIa Receptor with Integrilin Therapy (ESPRIT) trial showed the efficacy of adjunctive, double-bolus eptifibatide therapy in reducing ischemic complications of nonurgent coronary stent implantation at 4 ... Full text Link to item Cite

Evaluation Study of Congestive Heart Failure and Pulmonary Artery Catheterization Effectiveness (ESCAPE): design and rationale.

Journal Article Am Heart J · April 2001 Featured Publication BACKGROUND: There is little information about how to adjust pharmacologic agents in the treatment of patients with advanced congestive heart failure (CHF). Some studies have suggested that use of pulmonary artery catheterization to guide reductions in fill ... Full text Link to item Cite

Reactivation of ischemic events in acute coronary syndromes: results from GUSTO-IIb. Gobal Use of Strategies To Open occluded arteries in acute coronary syndromes.

Journal Article J Am Coll Cardiol · March 15, 2001 Featured Publication OBJECTIVES: We sought to determine the incidence of and risk factors for thrombotic events early after discontinuing antithrombin therapy in patients with acute coronary syndromes. BACKGROUND: Discontinuation of treatment with heparin and other thrombin in ... Full text Link to item Cite

Uses of epoetin for anemia in oncology.

Journal Article Evid Rep Technol Assess (Summ) · March 2001 Featured Publication Link to item Cite

Statistical methods for comparison to placebo in active-control trials

Journal Article Drug Information Journal · 2001 There has been a proliferation of active-control clinical trials comparing experimental therapies with standard ones (active control). In such cases, one often wants to know how the experimental therapy would have performed if it had been compared directly ... Cite

Novel dosing regimen of eptifibatide in planned coronary stent implantation (ESPRIT): a randomised, placebo-controlled trial.

Journal Article Lancet · December 16, 2000 BACKGROUND: The platelet glycoprotein IIb/IIIa inhibitors, although effective in reducing ischaemic complications of percutaneous coronary intervention, are used in few coronary stent implantation procedures. ESPRIT (Enhanced Suppression of the Platelet II ... Full text Link to item Cite

Reply.

Other J AAPOS · December 2000 Featured Publication Full text Link to item Cite

Relationship between transferrin saturation and iron stores in U.S. African-american and caucasian populations

Journal Article Blood · December 1, 2000 In previous analyses of transferrin saturation (TS), we found TS subpopulations consistent with population genetics for common loci that influence iron metabolism in African Americans and Caucasians (Gordeuk et al., Blood 1998:91:2175; McLaren et al., Bloo ... Cite

Management of preterm labor.

Journal Article Evid Rep Technol Assess (Summ) · October 2000 Featured Publication Link to item Cite

A clinical practice guideline for treating tobacco use and dependence: A US Public Health Service report. The Tobacco Use and Dependence Clinical Practice Guideline Panel, Staff, and Consortium Representatives.

Journal Article JAMA · June 28, 2000 OBJECTIVE: To summarize the recently published US Public Health Service report Treating Tobacco Use and Dependence: A Clinical Practice Guideline, which provides recommendations for brief clinical interventions, intensive clinical interventions, and system ... Link to item Cite

Accuracy of the Papanicolaou test in screening for and follow-up of cervical cytologic abnormalities: a systematic review.

Journal Article Ann Intern Med · May 16, 2000 Featured Publication PURPOSE: To evaluate the accuracy of conventional and new methods of Papanicolaou (Pap) testing when used to detect cervical cancer and its precursors. DATA SOURCES: Systematic search of English-language literature through October 1999 using MEDLINE, EMBAS ... Full text Link to item Cite

Single-therapy androgen suppression in men with advanced prostate cancer: a systematic review and meta-analysis.

Journal Article Ann Intern Med · April 4, 2000 Featured Publication PURPOSE: To compare luteinizing hormone-releasing hormone (LHRH) agonists with orchiectomy or diethylstilbestrol, and to compare antiandrogens with any of these three alternatives. DATA SOURCES: A search of the MEDLINE, Cancerlit, EMBASE, and Cochrane Libr ... Full text Link to item Cite

Does primary intraocular lens implantation prevent "aphakic" glaucoma in children?

Journal Article J AAPOS · February 2000 Featured Publication PURPOSE: Open-angle glaucoma may develop after surgery for congenital or developmental cataract with an incidence ranging from 3% to 41%. The pathogenesis of "aphakic" (open-angle) glaucoma remains unknown. Despite numerous reported clinical series (>1000 ... Full text Link to item Cite

Reply.

Other J Infect Dis · February 2000 Full text Link to item Cite

Clinical outcomes of bivalirudin for ischemic heart disease.

Journal Article Circulation · November 16, 1999 Featured Publication BACKGROUND: Current treatment strategies for percutaneous coronary revascularization and acute coronary syndromes incorporate thrombin inhibition with either unfractionated or fractionated heparin. The peptide bivalirudin (Hirulog) is a direct thrombin inh ... Full text Link to item Cite

Assessment of human exposure to ambient particulate matter.

Journal Article J Air Waste Manag Assoc · November 1999 Featured Publication Recent epidemiological studies have consistently shown that the acute mortality effects of high concentrations of ambient particulate matter (PM), documented in historic air pollution episodes, may also be occurring at the low to moderate concentrations of ... Full text Link to item Cite

Reduction in heart failure events by the addition of a clinical pharmacist to the heart failure management team: results of the Pharmacist in Heart Failure Assessment Recommendation and Monitoring (PHARM) Study.

Journal Article Arch Intern Med · September 13, 1999 Featured Publication BACKGROUND: The multidisciplinary approach to managing heart failure has been shown to improve outcomes. The role of a clinical pharmacist in treating heart failure has not been evaluated. METHODS: One hundred eighty-one patients with heart failure and lef ... Full text Link to item Cite

Hormone replacement therapy and the risk of colorectal cancer: a meta-analysis.

Journal Article Obstet Gynecol · May 1999 Featured Publication OBJECTIVE: To review systematically the association between hormone replacement therapy (HRT) and the risk of developing or dying from colorectal cancer. DATA SOURCES: We searched the English-language literature using MEDLINE, Current Contents, CancerLit, ... Full text Link to item Cite

Relative effectiveness and cost-effectiveness of methods of androgen suppression in the treatment of advanced prostate cancer.

Journal Article Evid Rep Technol Assess (Summ) · May 1999 Featured Publication OBJECTIVES: With 184,500 new cases and 39,200 deaths anticipated in 1998, prostate cancer is second only to lung cancer in cancer mortality for men. This report is a systematic review of the evidence from randomized controlled trials on the relative effect ... Link to item Cite

Meta-Analysis of Migraine Headache Treatments: Combining Information from Heterogeneous Designs

Journal Article Journal of the American Statistical Association · March 1, 1999 Migraine headache is a common condition in the United States for which a wide range of drug and nondrug treatments are available. There is wide disagreement about which treatments are most effective; meta-analysis of existing clinical trials can help to br ... Full text Cite

Quick Reference Guide for Smoking Cessation Specialists, Number 18, Smoking Cessation Information for Specialists

Journal Article Journal of Pharmacoepidemiology · January 5, 1999 This Quick Reference Guide for Smoking Cessation Specialists contains strategies and recommendations from Smoking Cessation Clinical Practice Guideline No. 18, designed to assist clinicians, smoking cessation specialists, and health care administrators/ins ... Cite

Patient Outcomes Research Teams: contribution to outcomes and effectiveness research.

Journal Article Annu Rev Public Health · 1999 Featured Publication This paper describes the key methodological and substantive findings of Patient Outcomes Research Teams, the first outcomes and effectiveness research centers funded by the Agency for Health Care Policy and Research. Patient Outcomes Research Teams contrib ... Full text Link to item Cite

Evaluation of cervical cytology.

Journal Article Evid Rep Technol Assess (Summ) · January 1999 Featured Publication Link to item Cite

Clinical outcomes of therapeutic agents that block the platelet glycoprotein IIb/IIIa integrin in ischemic heart disease.

Journal Article Circulation · December 22, 1998 Featured Publication BACKGROUND: Several platelet glycoprotein (GP) IIb/IIIa receptor antagonists have been evaluated in clinical trials. We conducted a systematic overview (meta-analysis) to assess the effect of these compounds on death, myocardial infarction (MI), and revasc ... Full text Link to item Cite

Hormone replacement therapy and the risk of colorectal cancer: a meta-analysis.

Journal Article Prim Care Update Ob Gyns · July 1, 1998 Featured Publication Objective: To review systematically the association between hormone replacement therapy and colorectal cancer incidence and mortality.Methods: We conducted a literature search of English-language studies using MEDLINE, Current Contents, CancerLit, and bibl ... Full text Link to item Cite

Is optimal angiotensin-converting enzyme inhibitor dosing neglected in elderly patients with heart failure?

Journal Article Am Heart J · July 1998 Featured Publication BACKGROUND: The benefit of angiotensin-converting enzyme (ACE) inhibitors on mortality in heart failure has been proved in randomized controlled trials. METHODS: We prospectively evaluated the prescribing of ACE inhibitors and the prescribing of target ACE ... Full text Link to item Cite

The Agency for Health Care Policy and Research Smoking Cessation Clinical Practice Guideline. Findings and implications for psychologists.

Journal Article Am Psychol · June 1998 Featured Publication Smoking is the leading cause of preventable morbidity and mortality in the United States, and the health benefits of quitting smoking are substantial. Nevertheless, over 25% of American adults (48 million individuals) continue to smoke, and the vast majori ... Full text Link to item Cite

Failure of the mandatory domestic violence reporting law to increase medical facility referral to police.

Journal Article Ann Emerg Med · April 1998 Featured Publication STUDY OBJECTIVE: To assess the effect of California's 1994 mandatory domestic violence reporting law on Los Angeles Sheriff's Department dispatches to medical facilities for domestic violence incidents. METHODS: This ecological time-trend study analyzed da ... Full text Link to item Cite

Cost-effectiveness of the AHCPR guidelines for smoking - Reply

Journal Article JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION · March 18, 1998 Link to item Cite

Distribution of transferrin saturations in the African-American population.

Journal Article Blood · March 15, 1998 Featured Publication To determine if transferrin saturations in African Americans may reflect the presence of a gene that influences iron metabolism, we analyzed the distribution of these values in 808 African Americans from the second National Health and Nutrition Survey. We ... Link to item Cite

Diagnostic efficiency of home pregnancy test kits. A meta-analysis.

Journal Article Arch Fam Med · 1998 Featured Publication OBJECTIVE: To assess the diagnostic efficiency of home pregnancy test (HPT) kits. DATA SOURCES: A literature search of English-language studies was performed with MEDLINE and a review of bibliographies. STUDY SELECTION: Studies were included if HPT kits we ... Full text Link to item Cite

Meta-analysis of multitreatment studies.

Journal Article Med Decis Making · 1998 Featured Publication Studies comparing more than two competing therapies are common in several fields, but standard meta-analytic methods can make only pairwise comparisons. The methods proposed in this article, a generalization of current meta-analytic methods, allow for any ... Full text Link to item Cite

Combining expert judgment by hierarchical modeling: An application to physician staffing

Journal Article Management Science · January 1, 1998 Expert panels are playing an increasingly important role in U.S. health policy decision making. A fundamental issue in these applications is how to synthesize the judgments of individual experts into a group judgment. In this paper we propose an approach t ... Full text Cite

Predicting the cost of illness: a comparison of alternative models applied to stroke.

Journal Article Med Decis Making · 1998 Featured Publication Predictions of cost over well-defined time horizons are frequently required in the analysis of clinical trials and social experiments, for decision models investigating the cost-effectiveness of interventions, and for macro-level estimates of the resource ... Full text Link to item Cite

Cost-effectiveness of the clinical practice recommendations in the AHCPR guideline for smoking cessation. Agency for Health Care Policy and Research.

Journal Article JAMA · December 3, 1997 Featured Publication CONTEXT: The Agency for Health Care Policy and Research (AHCPR) published the Smoking Cessation: Clinical Practice Guideline in 1996. Based on the results of meta-analyses and expert opinion, the guideline identifies efficacious interventions for primary c ... Link to item Cite

Cost-effectiveness of the clinical practice recommendations in the AHCPR guideline for smoking cessation

Journal Article JAMA · December 3, 1997 Context. - The Agency for Health Care Policy and Research (AHCPR) published the Smoking Cessation: Clinical Practice Guideline in 1996. Based on the results of meta-analyses and expert opinion, the guideline identifies efficacious interventions for primary ... Full text Cite

The Stroke Prevention Policy Model: linking evidence and clinical decisions.

Journal Article Ann Intern Med · October 15, 1997 Featured Publication Simulation models that support decision and cost-effectiveness analysis can further the goals of evidence-based medicine by facilitating the synthesis of information from several sources into a single comprehensive structure. The Stroke Prevention Policy M ... Full text Link to item Cite

Pediatric Vesicoureteral Reflux Guidelines Panel summary report on the management of primary vesicoureteral reflux in children.

Journal Article J Urol · May 1997 Featured Publication PURPOSE: The American Urological Association convened the Pediatric Vesicoureteral Reflux Guidelines Panel to analyze the literature regarding available methods for treating vesicoureteral reflux diagnosed following a urinary tract infection in children an ... Link to item Cite

Assessing uncertainty in cost-effectiveness analyses: application to a complex decision model.

Journal Article Med Decis Making · 1997 Featured Publication A framework for quantifying uncertainty about costs, effectiveness measures, and marginal cost-effectiveness ratios in complex decision models is presented. This type of application requires special techniques because of the multiple sources of information ... Full text Link to item Cite

A metaanalysis of predischarge risk stratification after acute myocardial infarction with stress electrocardiographic, myocardial perfusion, and ventricular function imaging.

Journal Article Am J Cardiol · December 15, 1996 Featured Publication We assessed the relation of abnormal predischarge non-invasive test results to outcomes in postmyocardial infarction patients. We included series published from 1980 to 1995 containing only myocardial infarction patients, enrolling most patients after 1980 ... Full text Link to item Cite

A clinical approach for the diagnosis of diabetes mellitus: an analysis using glycosylated hemoglobin levels. Meta-analysis Research Group on the Diagnosis of Diabetes Using Glycated Hemoglobin Levels.

Journal Article JAMA · October 16, 1996 Featured Publication OBJECTIVE: To determine whether a glycosylated hemoglobin level can be used in place of an oral glucose tolerance test (OGTT) to diagnose diabetes. DATA SOURCES/STUDY SELECTION: An augmented MEDLINE search was performed to identify all reports from 1966 th ... Link to item Cite

The Agency for Health Care Policy and Research Smoking Cessation Clinical Practice Guideline.

Journal Article JAMA · April 24, 1996 OBJECTIVE: To summarize the Smoking Cessation Clinical Practice Guideline that provides recommendations for 3 groups of professionals: primary care clinicians, smoking cessation specialists, and health care administrators, insurers, and purchasers. PARTICI ... Link to item Cite

Comparison and meta-analysis of randomized trials of endarterectomy for symptomatic carotid artery stenosis.

Journal Article Neurology · November 1995 Featured Publication OBJECTIVE: Comparison and meta-analysis of randomized trials of carotid endarterectomy for symptomatic stenosis of the extracranial carotid artery. BACKGROUND: Randomized trials (North American Symptomatic Carotid Endarterectomy Trial [NASCET], the Europea ... Full text Link to item Cite

Prevalence of heterozygotes for hemochromatosis in the white population of the United States.

Journal Article Blood · September 1, 1995 Featured Publication In previous studies, the prevalence of HLA-linked hemochromatosis, thought to be the most common genetic illness in whites, has been estimated by identifying homozygotes in the population. Because not all homozygotes express the disease phenotypically, the ... Link to item Cite

Noninvasive carotid artery testing. A meta-analytic review.

Journal Article Ann Intern Med · March 1, 1995 Featured Publication PURPOSE: To compare the operating characteristics of six noninvasive tests for carotid artery stenosis. DATA SOURCES: A structured search was done using MEDLINE, reference lists from selected articles, and bibliographies from neurology textbooks that focus ... Full text Link to item Cite

A survey of current problems in meta-analysis. Discussion from the Agency for Health Care Policy and Research inter-PORT Work Group on Literature Review/Meta-Analysis.

Journal Article Med Care · February 1995 Featured Publication The United States Agency for Health Care Policy and Research brought together representatives from each of the Patient Outcomes Research Teams (PORTs) as the Inter-PORT Meta-Analysis Work Group. The purpose of the meeting was to discuss a wide range of pro ... Link to item Cite

Meta-analysis of environmental health data.

Journal Article Sci Total Environ · January 15, 1995 Featured Publication Most airborne contaminants have minimal health effects at typical ambient levels, and this is especially true for contaminant levels in the Arctic. Among multiple studies of similar health effects, usually only one or two of the studies show statistically ... Full text Link to item Cite

Meta-analytic tools for medical decision making: a practical guide.

Journal Article Med Decis Making · 1995 Featured Publication This paper is an extension of notes used for the short course in meta-analysis given at the 13th and 14th annual meetings of the Society for Medical Decision Making. The material covers both standard and evolving methods of meta-analysis. The methods inclu ... Full text Link to item Cite

Meta-analysis of screening and diagnostic tests.

Journal Article Psychol Bull · January 1995 Featured Publication Screening and diagnostic tests are common in the fields of psychology, medicine, and education. Often there are several competing tests, and decisions must be made about the relative accuracy of those tests. This article describes a general measure that ca ... Full text Link to item Cite

Meta-analysis of screening and diagnostic tests

Journal Article Psychol Bull · 1995 Cite

21 Meta-analysis in environmental statistics

Journal Article Handbook of Statistics · December 1, 1994 The synthesis of evidence from different experiments or investigations is a challenging problem for environmental science. This chapter reviews standard methods for such synthesis, including combining p-values, effect sizes, and methods for combining conti ... Full text Cite

NUMERICAL TECHNIQUES IN DISTRIBUTION FITTING

Conference COMPUTING SCIENCE AND STATISTICS, VOL 26 · January 1, 1994 Link to item Cite

A STATISTICAL OVERVIEW OF NONINVASIVE CAROTID-ARTERY TESTING

Journal Article CLINICAL RESEARCH · December 1, 1993 Link to item Cite

Synthesis of environmental evidence: nitrogen dioxide epidemiology studies.

Journal Article J Air Waste Manage Assoc · May 1992 Featured Publication The use of meta-analysis is becoming more common in the medical literature, but it is not common in the environmental literature. Although meta-analysis cannot combine a group of poorly executed, conflicting studies to get an unequivocal answer, there are ... Full text Link to item Cite

ROLE OF EPIDEMIOLOGIC DATA IN ASSESSING HEALTH RISKS FOR SELECTED METALS

Journal Article ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY · April 5, 1992 Link to item Cite

An introduction to a Bayesian method for meta-analysis: The confidence profile method.

Journal Article Med Decis Making · 1990 Featured Publication The Confidence Profile Method is a new Bayesian method that can be used to assess technologies where the available evidence involves a variety of experimental designs, types of outcomes, and effect measures; a variety of biases; combinations of biases and ... Full text Link to item Cite

A Bayesian method for synthesizing evidence. The Confidence Profile Method.

Journal Article Int J Technol Assess Health Care · 1990 Featured Publication This article describes a collection of meta-analysis techniques based on Bayesian statistics for interpreting, adjusting, and combining evidence to estimate parameters and outcomes important to the assessment of health technologies. The result of an analys ... Full text Link to item Cite

AN INTRODUCTION TO A BAYESIAN METHOD FOR METAANALYSIS - THE CONFIDENCE PROFILE METHOD

Conference MODERN METHODS OF CLINICAL INVESTIGATION · January 1, 1990 Link to item Cite

The value of mammography screening in women under age 50 years

Journal Article Investigative Radiology · January 1, 1989 Cite

MATHEMATICS OF THE CONFIDENCE PROFILE METHOD

Journal Article MEDICAL DECISION MAKING · October 1, 1988 Link to item Cite

The value of mammography screening in women under age 50 years.

Journal Article JAMA · March 11, 1988 Featured Publication Two quantitative methods, Confidence Profiles and CAN*TROL, are used to analyze evidence and estimate the health and economic consequences of adding annual mammography to annual breast physical examinations in asymptomatic women aged 40 to 49 years who are ... Link to item Cite

MAMMOGRAPHY SCREENING IN WOMEN UNDER AGE 50 YEARS - REPLY

Journal Article JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION · 1988 Full text Cite

Statistical and graphical evaluation of erythrocyte volume distributions.

Journal Article Am J Physiol · April 1987 Featured Publication A protocol for the statistical and graphical evaluation of erythrocyte volume distributions has been developed using expectation-maximization methods for distribution parameter estimation. In a reference sample group of 50 healthy individuals, none of the ... Full text Link to item Cite

STATISTICAL AND GRAPHICAL EVALUATION OF ERYTHROCYTE VOLUME DISTRIBUTIONS

Journal Article AMERICAN JOURNAL OF PHYSIOLOGY · April 1, 1987 Link to item Cite

CONFIDENCE PROFILES - A BAYESIAN METHOD FOR SYNTHESIZING EVIDENCE

Journal Article MEDICAL DECISION MAKING · January 1, 1987 Link to item Cite

Analysis of the volume of red blood cells: application of the expectation-maximization algorithm to grouped data from the doubly-truncated lognormal distribution.

Journal Article Biometrics · March 1986 Featured Publication In accordance with general principles recommended by the International Committee for Standardization in Haematology (1982, Journal of Clinical Pathology 35, 1320-1322), we have developed statistical methods for the analysis of red cell volume distributions ... Link to item Cite

Prevalence of persistent cough and phlegm in young adults in relation to long-term ambient sulfur oxide exposure.

Journal Article Am Rev Respir Dis · August 1985 Featured Publication In early 1976, a survey of persistent cough and phlegm (PCP) prevalence was conducted in 5,623 young adults in 4 Utah communities. Over the previous 5 years, community-specific mean sulfur dioxide levels had been 11, 18, 36, and 115 micrograms/m3. Correspo ... Full text Link to item Cite

PREVALENCE OF PERSISTENT RESPIRATORY SYMPTOMS IN RELATION TO AMBIENT SULFUR OXIDE EXPOSURE

Journal Article AMERICAN REVIEW OF RESPIRATORY DISEASE · January 1, 1983 Link to item Cite

Corrigenda: Analysis of Coarsely Grouped Data from the Lognormal Distribution

Journal Article Journal of the American Statistical Association · December 1982 Full text Cite

DISFIT: A Program for Fitting Discrete Distributions to Data

Journal Article The American Statistician · November 1981 Full text Cite

Indoor environmental determinants of lung function in children.

Journal Article Am Rev Respir Dis · May 1981 Featured Publication Using pulmonary function and family respiratory questionnaire data for 16,689 white children 6 to 13 yr of age from 7 geographic areas, the investigators examined the effect of several environmental and other factors on performance, in a standard test of b ... Full text Link to item Cite

Modeling the Ames test.

Journal Article Mutat Res · February 1981 Featured Publication Despite the value and widespread use of the Ames test, little attention has been focused on standardizing quantitative methods of analyzing these data. In this paper, a realistic and statistically tractable model is developed for the evaluation of Ames-typ ... Full text Link to item Cite

DISFIT: A program for fitting discrete distributions to data

Journal Article American Statistician · January 1, 1981 Full text Cite

A STATISTICAL-MODEL FOR EVALUATING THE RESULTS OF AMES TYPE BIOASSAY DATA

Journal Article ENVIRONMENTAL MUTAGENESIS · January 1, 1981 Link to item Cite

Analysis of Coarsely Grouped Data from the Lognormal Distribution

Journal Article Journal of the American Statistical Association · December 1980 Full text Cite

Multiple Probit Analysis with a Nonzero Background

Journal Article Biometrics · December 1980 Full text Cite

Analysis of coarsely grouped data from the lognormal distribution

Journal Article Journal of the American Statistical Association · January 1, 1980 A missing information technique is applied to blood lead data that is both grouped and assumed to be lognormally distributed. These maximum likelihood techniques are extended from the simple lognormal case to obtain solutions for a general linear model cas ... Full text Cite

APPLICATIONS OF THE MIP TO ENVIRONMENTAL DATA

Journal Article BIOMETRICS · January 1, 1979 Link to item Cite

Spirometric changes in normal children with upper respiratory infections.

Journal Article Am Rev Respir Dis · January 1978 Featured Publication Recent evidence that certain uncomplicated upper respiratory infections induce pulmonary function abnormalities in adults prompted a prospective study in children, in whom such infections occur more frequently. In a longitudinal study, 55 children 2.5 to 1 ... Full text Link to item Cite

Additional analyses of the seven city lead study.

Journal Article Environ Qual Saf Suppl · 1975 Featured Publication Link to item Cite

NO2 exposure and ventilatory function in schoolchildren

Journal Article American Journal of Epidemiology · 1975 Cite

ADDITIONAL ANALYSES OF THE SEVEN CITY LEAD STUDY.

Journal Article Lead · January 1, 1975 Analysis of blood lead concentration as a function of air lead area differences is presented in graphical and tabular form. ... Cite

NO2 exposure and ventilatory function in schoolchildren

Journal Article American Journal of Epidemiology · January 1, 1975 Cite

Analysis of health effects data: some results and problems

Journal Article MARCEL DEKKER INC. · 1974 This paper describes an Environmental Protection Agency study program given the acronym CHESS, for Community Health and Environmental Surveillance System. The purpose of these studies is to relate air pollution levels to both acute and chronic human health ... Cite

Analysis of health effects data: some results and problems

Book · January 1, 1974 This paper describes an Environmental Protection Agency study program given the acronym CHESS, for Community Health and Environmental Surveillance System. The purpose of these studies is to relate air pollution levels to both acute and chronic human health ... Cite

Cadmium and lead in autopsy tissues.

Journal Article J Occup Med · December 1973 Featured Publication Link to item Cite

SO2 levels and perturbations in mortality. A study in the New York-New Jersey metropolis.

Journal Article Arch Environ Health · September 1973 Featured Publication Full text Link to item Cite

SO2 levels and perturbations in mortality: a study in the New York - New Jersey metropolis

Journal Article Archives of Environmental Health · 1973 Analysis of daily mortality for 422 places in the United States from 1962 to 1966 provided a consistent set of mortality predictors of three classes: annual cycle, day of week, and Christmas holidays; influenza epidemics; and days or spells of extreme cold ... Cite

Estimation of Finite Mixtures of Distributions from the Exponential Family

Journal Article Journal of the American Statistical Association · January 1, 1969 General “successive substitutions” iteration equations are developed for obtaining estimates for finite mixtures of distributions from the exponential family. These, in general, correspond to relative maximums of the likelihood function. It is assumed that ... Full text Cite

Dividing the blood pressures from the Los Angeles heart study into two normal distributions.

Journal Article Johns Hopkins Med J · February 1968 Featured Publication Link to item Cite

Estimation of Parameters for a Mixture of Normal Distributions

Journal Article Technometrics · January 1, 1966 In observations are taken from a mixture of K normal subpopulations, where the value of K is known. It is assumed that these n observations are given as N frequencies from equally spaced intervals. Initial guesses of the K means, K variances, and K − 1 pro ... Full text Cite

Certification of algorithm 224: Evaluation of determinant

Journal Article Communications of the ACM · December 1, 1964 Full text Cite