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John Samuel Wiener

Professor of Urology
Urology
Box 3831 Med Ctr, Durham, NC 27710
1572C Clin Res II, Durham, NC 27710

Selected Publications


Transitioning young adults with spina bifida: Challenges and paths to success.

Journal Article J Pediatr Urol · April 2024 INTRODUCTION AND BACKGROUND: Recent medical advances, including closure of myelomeningocele defects, shunting of hydrocephalus, and focusing on renal preservation have led to many individuals with spina bifida (SB) living into adulthood. This has led to mo ... Full text Link to item Cite

Urinary and Fecal Incontinence During Sexual Activity Is Common and Bothersome Among Adults With Spina Bifida.

Journal Article Urology · April 2024 OBJECTIVE: To evaluate the prevalence of and risk factors for urinary fecal incontinence (UI, FI) during sexual activity (UIS, FIS) among adults with spina bifida (SB). METHODS: An international online survey of adults with SB was administered through SB c ... Full text Link to item Cite

Prevalence of sexual abuse and intimate partner violence in adults with spina bifida.

Journal Article Disabil Health J · March 20, 2024 BACKGROUND: People with disabilities and chronic medical conditions are known to be at higher risk of sexual abuse (SA) and intimate partner violence (IPV). People with spina bifida (SB) are vulnerable, but little is known about the prevalence of abuse in ... Full text Open Access Link to item Cite

Comparing binary & ordinal definitions of urinary & stool continence outcomes: Data from the National Spina Bifida Patient Registry.

Journal Article J Pediatr Urol · February 7, 2024 INTRODUCTION: The National Spina Bifida Patient Registry (NSBPR) assesses bladder and bowel incontinence using ordinal categories, but prior NSBPR analyses employed binary classification. Our aims were to 1) perform the first NSBPR analysis of bladder and ... Full text Link to item Cite

What the editors are reading: Adolescent urology.

Journal Article J Pediatr Urol · February 2024 Full text Link to item Cite

Age-Specific Probability of 4 Major Health Outcomes in Children with Spina Bifida.

Journal Article J Dev Behav Pediatr · December 1, 2023 OBJECTIVE: This study aimed to estimate the age-specific probability of 4 health outcomes in a large registry of individuals with spina bifida (SB). METHODS: The association between age and 4 health outcomes was examined in individuals with myelomeningocel ... Full text Open Access Link to item Cite

Neurogenic Lower Urinary Tract Dysfunction.

Journal Article Urol Clin North Am · August 2023 Neurogenic lower urinary tract dysfunction (NLUTD) remains a formidable challenge to pediatric urologists to achieve the goals of renal preservation and the reduction of urinary tract infections as well as the attainment of continence and independence as c ... Full text Link to item Cite

Codevelopment of an illustration representative of people living with spina bifida for health educational materials.

Journal Article Disabil Health J · July 2023 BACKGROUND: The lack of health education resources specific to people with disabilities contributes to disparities in outcomes. Developing user-centered materials with representative images tailored to people with disabilities could help improve knowledge ... Full text Link to item Cite

Single-port hidden incision endoscopic (HIdES) pediatric nephrectomy via pfannenstiel incision.

Conference J Pediatr Urol · June 2023 Laparoendoscopic single-site surgery (LESS) and hidden incision endoscopic surgery techniques are increasingly used in pediatric urology. For pediatric nephrectomy, access through a single Pfannenstiel incision is novel and may offer cosmetic benefit. In t ... Full text Link to item Cite

Education and employment as young adults living with spina bifida transition to adulthood in the USA: A study of the National Spina Bifida Patient Registry.

Journal Article Dev Med Child Neurol · June 2023 AIM: To describe the education and employment transition experience of young adults with spina bifida (YASB) and investigate factors associated with employment. METHOD: We queried education and employment data from the US National Spina Bifida Patient Regi ... Full text Link to item Cite

Sexual activity and function of adult men with spina bifida.

Journal Article J Pediatr Urol · June 2023 OBJECTIVE: Data on sexual function of men with spina bifida (SB) is limited. We aimed to assess sexual activity and erectile dysfunction (ED) in a large international sample of men with SB. METHODS: Men with SB (≥18yo) were recruited in an international on ... Full text Link to item Cite

Medical management of neurogenic bladder in patients with spina bifida: A scoping review.

Journal Article J Pediatr Urol · February 2023 INTRODUCTION: Neurogenic bladder is a common source of morbidity in patients with spina bifida and can cause renal damage. Medical management may include imaging, urodynamic studies (UDS), laboratory testing, clean intermittent catheterization (CIC), and m ... Full text Link to item Cite

Pediatric genitourinary disorders

Chapter · January 1, 2023 Pediatric urology encompasses a wide spectrum of genitourinary disorders ranging from minor birth defects to life-threatening malignancies. An understanding of the embryology of the urinary and genital tracts, as well as functional development of processes ... Full text Cite

Causes of death among people with myelomeningocele: A multi-institutional 47-year retrospective study.

Journal Article J Pediatr Rehabil Med · 2023 PURPOSE: This study aimed to analyze organ system-based causes and non-organ system-based mechanisms of death (COD, MOD) in people with myelomeningocele (MMC), comparing urological to other COD. METHODS: A retrospective review was performed of 16 instituti ... Full text Open Access Link to item Cite

Solo and Partnered Sexual Behavior Among an International Sample of Adults With Spina Bifida.

Journal Article J Sex Med · December 2022 BACKGROUND: Spina bifida (SB) may differentially impact adults' participation in solo and partnered sexual behaviors, but little research investigates this topic. AIM: Describe solo and partnered sexual behaviors among an international sample of adult men ... Full text Link to item Cite

Solo and Partnered Sexual Behavior Among an International Sample of Adults with Spina Bifida.

Journal Article J Sex Med · December 1, 2022 BACKGROUND: Spina bifida (SB) may differentially impact adults' participation in solo and partnered sexual behaviors, but little research investigates this topic. AIM: Describe solo and partnered sexual behaviors among an international sample of adult men ... Full text Link to item Cite

Framing the picture: Impact of radiographic imaging on parental vesicoureteral reflux management preferences.

Journal Article J Pediatr Urol · October 2022 INTRODUCTION/OBJECTIVE: Given the variety of treatment options for vesicoureteral reflux (VUR), shared decision making between clinicians and parents is essential. Despite its importance, shared decision making is limited by the framing effect - people pro ... Full text Link to item Cite

Transitioning young adults with spina bifida: Challenges and paths to success.

Journal Article J Pediatr Urol · April 2024 INTRODUCTION AND BACKGROUND: Recent medical advances, including closure of myelomeningocele defects, shunting of hydrocephalus, and focusing on renal preservation have led to many individuals with spina bifida (SB) living into adulthood. This has led to mo ... Full text Link to item Cite

Urinary and Fecal Incontinence During Sexual Activity Is Common and Bothersome Among Adults With Spina Bifida.

Journal Article Urology · April 2024 OBJECTIVE: To evaluate the prevalence of and risk factors for urinary fecal incontinence (UI, FI) during sexual activity (UIS, FIS) among adults with spina bifida (SB). METHODS: An international online survey of adults with SB was administered through SB c ... Full text Link to item Cite

Prevalence of sexual abuse and intimate partner violence in adults with spina bifida.

Journal Article Disabil Health J · March 20, 2024 BACKGROUND: People with disabilities and chronic medical conditions are known to be at higher risk of sexual abuse (SA) and intimate partner violence (IPV). People with spina bifida (SB) are vulnerable, but little is known about the prevalence of abuse in ... Full text Open Access Link to item Cite

Comparing binary & ordinal definitions of urinary & stool continence outcomes: Data from the National Spina Bifida Patient Registry.

Journal Article J Pediatr Urol · February 7, 2024 INTRODUCTION: The National Spina Bifida Patient Registry (NSBPR) assesses bladder and bowel incontinence using ordinal categories, but prior NSBPR analyses employed binary classification. Our aims were to 1) perform the first NSBPR analysis of bladder and ... Full text Link to item Cite

What the editors are reading: Adolescent urology.

Journal Article J Pediatr Urol · February 2024 Full text Link to item Cite

Age-Specific Probability of 4 Major Health Outcomes in Children with Spina Bifida.

Journal Article J Dev Behav Pediatr · December 1, 2023 OBJECTIVE: This study aimed to estimate the age-specific probability of 4 health outcomes in a large registry of individuals with spina bifida (SB). METHODS: The association between age and 4 health outcomes was examined in individuals with myelomeningocel ... Full text Open Access Link to item Cite

Neurogenic Lower Urinary Tract Dysfunction.

Journal Article Urol Clin North Am · August 2023 Neurogenic lower urinary tract dysfunction (NLUTD) remains a formidable challenge to pediatric urologists to achieve the goals of renal preservation and the reduction of urinary tract infections as well as the attainment of continence and independence as c ... Full text Link to item Cite

Codevelopment of an illustration representative of people living with spina bifida for health educational materials.

Journal Article Disabil Health J · July 2023 BACKGROUND: The lack of health education resources specific to people with disabilities contributes to disparities in outcomes. Developing user-centered materials with representative images tailored to people with disabilities could help improve knowledge ... Full text Link to item Cite

Single-port hidden incision endoscopic (HIdES) pediatric nephrectomy via pfannenstiel incision.

Conference J Pediatr Urol · June 2023 Laparoendoscopic single-site surgery (LESS) and hidden incision endoscopic surgery techniques are increasingly used in pediatric urology. For pediatric nephrectomy, access through a single Pfannenstiel incision is novel and may offer cosmetic benefit. In t ... Full text Link to item Cite

Education and employment as young adults living with spina bifida transition to adulthood in the USA: A study of the National Spina Bifida Patient Registry.

Journal Article Dev Med Child Neurol · June 2023 AIM: To describe the education and employment transition experience of young adults with spina bifida (YASB) and investigate factors associated with employment. METHOD: We queried education and employment data from the US National Spina Bifida Patient Regi ... Full text Link to item Cite

Sexual activity and function of adult men with spina bifida.

Journal Article J Pediatr Urol · June 2023 OBJECTIVE: Data on sexual function of men with spina bifida (SB) is limited. We aimed to assess sexual activity and erectile dysfunction (ED) in a large international sample of men with SB. METHODS: Men with SB (≥18yo) were recruited in an international on ... Full text Link to item Cite

Medical management of neurogenic bladder in patients with spina bifida: A scoping review.

Journal Article J Pediatr Urol · February 2023 INTRODUCTION: Neurogenic bladder is a common source of morbidity in patients with spina bifida and can cause renal damage. Medical management may include imaging, urodynamic studies (UDS), laboratory testing, clean intermittent catheterization (CIC), and m ... Full text Link to item Cite

Pediatric genitourinary disorders

Chapter · January 1, 2023 Pediatric urology encompasses a wide spectrum of genitourinary disorders ranging from minor birth defects to life-threatening malignancies. An understanding of the embryology of the urinary and genital tracts, as well as functional development of processes ... Full text Cite

Causes of death among people with myelomeningocele: A multi-institutional 47-year retrospective study.

Journal Article J Pediatr Rehabil Med · 2023 PURPOSE: This study aimed to analyze organ system-based causes and non-organ system-based mechanisms of death (COD, MOD) in people with myelomeningocele (MMC), comparing urological to other COD. METHODS: A retrospective review was performed of 16 instituti ... Full text Open Access Link to item Cite

Solo and Partnered Sexual Behavior Among an International Sample of Adults With Spina Bifida.

Journal Article J Sex Med · December 2022 BACKGROUND: Spina bifida (SB) may differentially impact adults' participation in solo and partnered sexual behaviors, but little research investigates this topic. AIM: Describe solo and partnered sexual behaviors among an international sample of adult men ... Full text Link to item Cite

Solo and Partnered Sexual Behavior Among an International Sample of Adults with Spina Bifida.

Journal Article J Sex Med · December 1, 2022 BACKGROUND: Spina bifida (SB) may differentially impact adults' participation in solo and partnered sexual behaviors, but little research investigates this topic. AIM: Describe solo and partnered sexual behaviors among an international sample of adult men ... Full text Link to item Cite

Framing the picture: Impact of radiographic imaging on parental vesicoureteral reflux management preferences.

Journal Article J Pediatr Urol · October 2022 INTRODUCTION/OBJECTIVE: Given the variety of treatment options for vesicoureteral reflux (VUR), shared decision making between clinicians and parents is essential. Despite its importance, shared decision making is limited by the framing effect - people pro ... Full text Link to item Cite

Financial toxicity among individuals with spina bifida and their families: A qualitative study and conceptual model.

Journal Article J Pediatr Urol · June 2022 INTRODUCTION: Spina bifida is the most common permanently disabling birth defect in the United States and requires lifelong, multi-specialty care. The cost of such care has the potential to result in financial toxicity - the 'objective financial burden' an ... Full text Link to item Cite

Editorial Comment.

Journal Article J Urol · January 2022 Full text Link to item Cite

Neurosurgical procedures for children with myelomeningocele after fetal or postnatal surgery: a comparative effectiveness study.

Journal Article Dev Med Child Neurol · November 2021 AIM: To compare the frequencies of neurosurgical procedures to treat comorbid conditions of myelomeningocele in patients who underwent fetal surgery versus postnatal surgery for closure of the placode. METHOD: By utilizing the National Spina Bifida Patient ... Full text Link to item Cite

Sexual Function and Dysfunction in Individuals with Spina Bifida: A Systematic Review.

Journal Article Urology · October 2021 OBJECTIVE: To conduct a systematic review of self-reported experiences of sexual function and dysfunction in individuals with spina bifida (SB). MATERIALS AND METHODS: Medline, Embase, and Web of Science were systematically searched. Studies included conta ... Full text Link to item Cite

Urodynamic characteristics of neurogenic bladder in newborns with myelomeningocele and refinement of the definition of bladder hostility: Findings from the UMPIRE multi-center study.

Journal Article J Pediatr Urol · October 2021 INTRODUCTION: Infants with myelomeningocele are at risk for chronic kidney disease caused by neurogenic bladder dysfunction. Urodynamic evaluation plays a key role to risk stratify individuals for renal deterioration. OBJECTIVE: To present baseline urodyna ... Full text Link to item Cite

Translating pediatric urodynamics from clinic into collaborative research: Lessons and recommendations from the UMPIRE study group.

Journal Article J Pediatr Urol · October 2021 Pediatric patients present unique challenges in the performance and interpretation of urodynamic studies. Interpretation of urodynamics to guide clinical management at an institutional level is accepted as reliable. Challenges arise however when multi-site ... Full text Link to item Cite

Incidence of Urinary Tract Infections in Newborns with Spina Bifida-Is Antibiotic Prophylaxis Necessary?

Journal Article J Urol · July 2021 PURPOSE: Urinary tract infections commonly occur in patients with spina bifida and pose a risk of renal scarring. Routine antibiotic prophylaxis has been utilized in newborns with spina bifida to prevent urinary tract infections. We hypothesized that proph ... Full text Link to item Cite

Pediatric Urology.

Journal Article J Urol · July 2021 Full text Link to item Cite

Challenges in pediatric urologic practice: a lifelong view.

Journal Article World J Urol · April 2021 The role of the pediatric urologic surgeon does not end with initial reconstructive surgery. Many of the congenital anomalies encountered require multiple staged operations while others may not involve further surgery but require a life-long follow-up and ... Full text Open Access Link to item Cite

Editorial Comment.

Journal Article J Urol · April 2021 Full text Link to item Cite

Sexual Function of Men and Women With Spina Bifida: A Scoping Literature Review.

Journal Article Sex Med Rev · April 2021 INTRODUCTION: As most adults with spina bifida are either sexually active or interested in becoming sexually active, providers should understand how spina bifida impacts sexual function and options for treatment. OBJECTIVES: The objective of this study is ... Full text Link to item Cite

Immune Expression in Children With Vesicoureteral Reflux: A Pilot Study.

Journal Article Urology · February 2021 OBJECTIVE: To perform an exploratory, descriptive pilot study of the systemic and local immune environment in patients with vesicoureteral reflux (VUR) and bladder-bowel dysfunction (BBD). METHODS: Consecutive children with VUR undergoing intravesical uret ... Full text Link to item Cite

Parental preferences for vesicoureteral reflux treatment: Profile case best-worst scaling.

Journal Article J Pediatr Urol · February 2021 INTRODUCTION: Vesicoureteral reflux is a common pediatric urologic condition that often has several reasonable treatment options depending on condition severity. In order to choose the best treatment for their child, parents are expected to make judgements ... Full text Link to item Cite

EDITORIAL COMMENT.

Journal Article Urology · February 2021 Full text Link to item Cite

The Importance of Early Diagnosis and Management of Pediatric Neurogenic Bladder Dysfunction.

Journal Article Res Rep Urol · 2021 Neurogenic bladder dysfunction is a major source of urologic morbidity in children, especially in those with spina bifida (SB). Complications from progression of bladder dysfunction can include urinary tract infections (UTIs), urinary incontinence, upper t ... Full text Open Access Link to item Cite

Who is managing the bowels? A survey of clinical practice patterns in spina bifida clinics.

Journal Article J Pediatr Rehabil Med · 2021 PURPOSE: Neurogenic bowel dysfunction (NBD) affects 80% of individuals with spina bifida. Performing and disseminating research on NBD to reach the appropriate audience is difficult given the variability among medical specialties managing NBD. This study a ... Full text Link to item Cite

Association between race and in-hospital outcomes in children with spina bifida following inpatient urologic surgery.

Journal Article J Pediatr Rehabil Med · 2021 PURPOSE: Post-operative complication rates may vary among racial and/or ethnic groups and have not been previously described in individuals with spina bifida (SB) undergoing urologic surgery. The aim of this study was to compare in-hospital complication fr ... Full text Link to item Cite

Delayed presentation of urethrocutaneous fistulae after hypospadias repair.

Journal Article J Pediatr Surg · October 2020 BACKGROUND: Delayed urethrocutaneous fistula (UCF) presentation after hypospadias repair is rarely reported. The aim of this study is to report our experience with delayed UCF presenting more than 5 years after hypospadias repair. METHODS: We conducted a r ... Full text Open Access Link to item Cite

Pediatric Neurogenic Bladder and Bowel Dysfunction: Will My Child Ever Be out of Diapers?

Journal Article Eur Urol Focus · September 15, 2020 CONTEXT: Managing patient and parent expectations regarding urinary and fecal continence is important with congenital conditions that produce neurogenic bladder and bowel dysfunction. Physicians need to be aware of common treatment algorithms and expected ... Full text Open Access Link to item Cite

"I Tell Them What I Can Feel and How Far My Legs Can Bend": Optimizing Sexual Satisfaction for Women With Spina Bifida.

Journal Article J Sex Med · September 2020 BACKGROUND: There is a high reported rate of sexual dysfunction among women with spina bifida, but little is known about the etiology of this or how sexual satisfaction could be improved. AIM: To identify, through the words of women with spina bifida, perc ... Full text Link to item Cite

Editorial Comment.

Journal Article J Urol · July 2020 Full text Link to item Cite

Patterns of inpatient care for prostate cancer in men with spina bifida.

Journal Article Disabil Health J · April 2020 BACKGROUND: Advances in medical care have increased the long-term survival of patients with spina bifida. Despite this growing population, limited knowledge is available on age-related illnesses in adults with spina bifida, particularly prostate cancer for ... Full text Open Access Link to item Cite

Neurogenic bowel treatments and continence outcomes in children and adults with myelomeningocele.

Journal Article J Pediatr Rehabil Med · 2020 PURPOSE: Neurogenic bowel dysfunction (NBD) is a common comorbidity of myelomeningocele (MMC), the most common and severe form of spina bifida. The National Spina Bifida Patient Registry (NSBPR) is a research collaboration between the CDC and Spina Bifida ... Full text Link to item Cite

A Genocentric Approach to Discovery of Mendelian Disorders.

Journal Article Am J Hum Genet · November 7, 2019 The advent of inexpensive, clinical exome sequencing (ES) has led to the accumulation of genetic data from thousands of samples from individuals affected with a wide range of diseases, but for whom the underlying genetic and molecular etiology of their cli ... Full text Open Access Link to item Cite

National Imaging and Antibiotic Practice Patterns in Children Presenting With Urinary Tract Infection to Community Practices: Little Impact From the American Academy of Pediatrics Guidelines?

Journal Article Clin Pediatr (Phila) · October 2019 Our objective was to use community-based, national databases to evaluate diagnostic imaging and antibiotic prophylaxis practice patterns before and after the release of the 2011 American Academy of Pediatrics guidelines for acute febrile urinary tract infe ... Full text Link to item Cite

Editorial Comment.

Journal Article J Urol · September 2019 Full text Link to item Cite

Hospital and ED charges for spina bifida care in the United States between 2006 and 2014: Over $2 billion annually.

Journal Article Disabil Health J · July 2019 BACKGROUND: More children with spina bifida (SB) are surviving into adulthood. Unfortunately, little data exist regarding the economic implications of modern SB care. OBJECTIVE: We examined economic data from two national databases to estimate the annual n ... Full text Link to item Cite

Baseline Urinary Tract Imaging in Infants Enrolled in the UMPIRE Protocol for Children with Spina Bifida.

Journal Article J Urol · June 2019 PURPOSE: The lifetime risk of renal damage in children with spina bifida is high but only limited baseline imaging data are available for this population. We evaluated a large prospective cohort of infants with spina bifida to define their baseline imaging ... Full text Link to item Cite

Parental Preferences for Vesicoureteral Reflux Treatment: A Crowd-sourced, Best-worst Scaling Study.

Journal Article Urology · June 2019 OBJECTIVE: To quantitatively evaluate parental preferences for the various treatments for vesicoureteral reflux using crowd-sourced best-worst scaling, a novel technique in urologic preference estimation. METHODS: Preference data were collected from a comm ... Full text Open Access Link to item Cite

Mutations in NCAPG2 Cause a Severe Neurodevelopmental Syndrome that Expands the Phenotypic Spectrum of Condensinopathies.

Journal Article Am J Hum Genet · January 3, 2019 The use of whole-exome and whole-genome sequencing has been a catalyst for a genotype-first approach to diagnostics. Under this paradigm, we have implemented systematic sequencing of neonates and young children with a suspected genetic disorder. Here, we r ... Full text Open Access Link to item Cite

Lower Urinary Tract Symptoms in Older Children With and Without Diabetes Mellitus.

Journal Article Clin Pediatr (Phila) · November 2018 Lower urinary tract symptoms (LUTS) are an underrecognized complication of diabetes mellitus (DM) in adults and have undergone limited investigation in children. We estimated the prevalence of LUTS in 120 older children (11-17 years) with and without DM an ... Full text Link to item Cite

Predominant bacteria and patterns of antibiotic susceptibility in urinary tract infection in children with spina bifida.

Journal Article J Pediatr Urol · October 2018 BACKGROUND: Urinary tract infection is more common in children with spina bifida (SB) than neurologically intact children, and Escherichia coli is the most common urinary pathogen in the general pediatric population. Less is known of the pathogens responsi ... Full text Link to item Cite

Surgeries and Health Outcomes Among Patients With Spina Bifida.

Journal Article Pediatrics · September 2018 BACKGROUND AND OBJECTIVES: Patients with spina bifida (SB) typically develop serious secondary conditions and undergo surgical procedures related to neurologic disorders, orthopedic abnormalities, bladder and bowel dysfunction, and skin breakdown. In this ... Full text Link to item Cite

Effect of the Adoption of a Comprehensive Electronic Health Record on Graduate Medical Education: Perceptions of Faculty and Trainees.

Journal Article South Med J · August 2018 OBJECTIVES: Health systems are adopting electronic health records (EHRs). There are few studies on the effects of EHR implementation on graduate medical education. The authors sought to longitudinally assess perceptions of the impact of EHRs on graduate me ... Full text Link to item Cite

Bladder Management and Continence Outcomes in Adults with Spina Bifida: Results from the National Spina Bifida Patient Registry, 2009 to 2015.

Journal Article J Urol · July 2018 PURPOSE: Most children with spina bifida now survive into adulthood, although most have neuropathic bladder with potential complications of incontinence, infection, renal damage and diminished quality of life. In this study we sought to 1) describe contemp ... Full text Link to item Cite

The evaluation of three comorbidity indices in predicting postoperative complications and readmissions in pediatric urology.

Journal Article J Pediatr Urol · June 2018 INTRODUCTION: The surgical comorbidity assessment is important for patient risk stratification, counseling, and research. In adults, risk assessment indices, such as the Charlson Co-morbidity Score (CCS) or Van Walraven Index (VWI), are well established. I ... Full text Link to item Cite

Editorial Comment.

Journal Article J Urol · June 2018 Full text Open Access Link to item Cite

Spina Bifida Health-care Guidelines for Men's Health.

Journal Article Urology · June 2018 Spina bifida has traditionally been regarded as a pediatric health issue with little regard to adult consequences of the disorder. The congenital neurologic and urologic anomalies, as well as sequelae of bladder management, can have a profound impact on ad ... Full text Link to item Cite

Interrater Reliability in Interpretation of Neuropathic Pediatric Urodynamic Tracings: An Expanded Multicenter Study.

Journal Article J Urol · May 2018 PURPOSE: Urodynamic findings often guide treatment for neuropathic bladder and are reported as objective data points in multi-institutional trials. However, urodynamic interpretation can be variable. In a pilot study pediatric urologists interpreting video ... Full text Link to item Cite

Contemporary Demographic, Treatment, and Geographic Distribution Patterns for Disorders of Sex Development.

Journal Article Clin Pediatr (Phila) · March 2018 This study aimed to describe the demographic characteristics, hospital utilizations, patterns of inpatient surgical management, and the overall state/regional variation in surgery rate among patients with disorders of sex development (DSD). We analyzed the ... Full text Link to item Cite

Longitudinal Study of Bladder Continence in Patients with Spina Bifida in the National Spina Bifida Patient Registry.

Journal Article J Urol · March 2018 PURPOSE: Achieving bladder continence in individuals with spina bifida is a lifetime management goal. We investigated bladder continence status through time and factors associated with this status in patients with spina bifida. MATERIALS AND METHODS: We us ... Full text Link to item Cite

Bladder Reconstruction Rates Differ among Centers Participating in National Spina Bifida Patient Registry.

Journal Article J Urol · January 2018 PURPOSE: We performed an exploratory analysis of data from the NSBPR (National Spina Bifida Patient Registry) to assess variation in the frequency of bladder reconstruction surgeries among NSBPR centers. MATERIALS AND METHODS: We queried the 2009-2014 NSBP ... Full text Link to item Cite

Bowel management and continence in adults with spina bifida: Results from the National Spina Bifida Patient Registry 2009-15.

Journal Article J Pediatr Rehabil Med · December 11, 2017 INTRODUCTION: Advances in care have allowed most children with spina bifida (SB) to live to adulthood. The majority have neuropathic bowel dysfunction (NBD), resulting in constipation, incontinence, and diminished quality of life. We sought to 1) describe ... Full text Link to item Cite

Variation in bowel and bladder continence across US spina bifida programs: A descriptive study.

Journal Article J Pediatr Rehabil Med · December 11, 2017 PURPOSE: Continence is low in individuals with spina bifida, but published prevalence varies markedly across studies. The objective of this study was to examine bladder and bowel continence among patients served by multidisciplinary clinics participating i ... Full text Link to item Cite

Sexual identity and orientation in adult men and women with spina bifida.

Journal Article J Pediatr Rehabil Med · December 11, 2017 PURPOSE: Sexuality has received little attention in spina bifida (SB) care. The aim of this study was to assess sexual identity and orientation in adults with SB. METHODS: An international online survey to adults with SB was administered over 10-months (re ... Full text Link to item Cite

Genetic epidemiology of neural tube defects.

Journal Article J Pediatr Rehabil Med · December 11, 2017 It has been estimated that 60-70% of neural tube defects (NTDs) have a genetic component, but few causative genes have been identified. The lack of information on genes associated with non-syndromic NTDs in humans is especially notable as the "genomic revo ... Full text Link to item Cite

Variation in surgical management of neurogenic bowel among centers participating in National Spina Bifida Patient Registry.

Journal Article J Pediatr Rehabil Med · December 11, 2017 PURPOSE: Optimal management of neurogenic bowel in patients with spina bifida (SB) remains controversial. Surgical interventions may be utilized to treat constipation and provide fecal continence, but their use may vary among SB treatment centers. METHODS: ... Full text Link to item Cite

Readmissions, unplanned emergency room visits, and surgical retreatment rates after anti-reflux procedures.

Journal Article J Pediatr Urol · October 2017 INTRODUCTION/BACKGROUND: The choice between endoscopic injection (EI) and ureteroneocystotomy (UNC) for surgical correction of vesicoureteral reflux (VUR) is controversial. OBJECTIVE: To compare postoperative outcomes of EI vs UNC. STUDY DESIGN: This study ... Full text Link to item Cite

The association between caudal anesthesia and increased risk of postoperative surgical complications in boys undergoing hypospadias repair.

Journal Article Paediatr Anaesth · July 2017 INTRODUCTION: Recent reports have suggested that caudal anesthesia may be associated with an increased risk of postoperative surgical complications. We examined our experience with caudal anesthesia in hypospadias repair to evaluate for increased risk of u ... Full text Link to item Cite

Open versus minimally invasive surgical approaches in pediatric urology: Trends in utilization and complications.

Journal Article J Pediatr Urol · June 2017 OBJECTIVE: Minimally invasive surgery (MIS) techniques are anecdotally reported to be increasingly used, but little objective data supports this. Our objective was to assess trends in MIS utilization across various procedures in pediatric urology and to co ... Full text Link to item Cite

Risk Factors Associated With Recurrent Urinary Tract Infection in Neurogenic Bladders Managed by Clean Intermittent Catheterization.

Journal Article Urology · April 2017 OBJECTIVE: To identify risk factors for recurrent urinary tract infection (UTI) in patients who perform clean intermittent catheterization (CIC). METHODS: A 6-year retrospective chart review of patients with spina bifida or tethered cord who perform clean ... Full text Link to item Cite

Editorial Comment.

Other J Urol · March 2017 Full text Link to item Cite

Increased pediatric sub-specialization is associated with decreased surgical complication rates for inpatient pediatric urology procedures.

Journal Article J Pediatr Urol · December 2016 INTRODUCTION: Increased case volumes and training are associated with better surgical outcomes. However, the impact of pediatric urology sub-specialization on perioperative complication rates is unknown. OBJECTIVES: To determine the presence and magnitude ... Full text Link to item Cite

Design and Methodological Considerations of the Centers for Disease Control and Prevention Urologic and Renal Protocol for the Newborn and Young Child with Spina Bifida.

Journal Article J Urol · December 2016 PURPOSE: Care of children with spina bifida has significantly advanced in the last half century, resulting in gains in longevity and quality of life for affected children and caregivers. Bladder dysfunction is the norm in patients with spina bifida and may ... Full text Link to item Cite

Developing Teaching Strategies in the EHR Era: A Survey of GME Experts.

Journal Article J Grad Med Educ · October 2016 BACKGROUND: There is limited information on the impact of widespread adoption of the electronic health record (EHR) on graduate medical education (GME). OBJECTIVE: To identify areas of consensus by education experts, where the use of EHR impacts GME, with ... Full text Link to item Cite

Open versus minimally invasive ureteroneocystostomy: A population-level analysis.

Journal Article J Pediatr Urol · August 2016 INTRODUCTION: Open ureteroneocystostomy (UNC) is the gold standard for surgical correction of vesicoureteral reflux (VUR). Beyond single-center reports, there are few published data on outcomes of minimally-invasive (MIS) UNC. Our objective was to compare ... Full text Link to item Cite

Is the Economic Impact and Utilization of Imaging Studies for Pediatric Urolithiasis Across the United States Increasing?

Journal Article Urology · August 2016 OBJECTIVE: To identify longitudinal trends of economic impact and resource utilization for management of pediatric urolithiasis using national databases. METHODS: We analyzed the 2006-2012 Nationwide Emergency Department Sample and Nationwide Inpatient Sam ... Full text Link to item Cite

Outcomes of Shock Wave Lithotripsy and Ureteroscopy for Treatment of Pediatric Urolithiasis.

Journal Article J Urol · July 2016 PURPOSE: Shock wave lithotripsy has been commonly used to treat children with renal and ureteral calculi but recently ureteroscopy has been used more frequently. We examined postoperative outcomes from these 2 modalities in children. MATERIALS AND METHODS: ... Full text Link to item Cite

Nationwide Trends and Variations in Urological Surgical Interventions and Renal Outcome in Patients with Spina Bifida.

Journal Article J Urol · April 2016 PURPOSE: Bladder dysfunction in patients with spina bifida can lead to significant morbidity due to renal insufficiency. Indications for surgery vary among institutions and the impact is unclear. We examined trends and variations in urological intervention ... Full text Link to item Cite

Trends in Sickle Cell Disease-related Priapism in U.S. Children's Hospitals.

Journal Article Urology · March 2016 OBJECTIVE: To define rates of priapism diagnosis and inpatient admission among males with sickle cell disease (SCD). PATIENTS AND METHODS: We retrospectively reviewed the Pediatric Health Information System database for males aged <21 years treated 2004-20 ... Full text Link to item Cite

Rare variants in tenascin genes in a cohort of children with primary vesicoureteric reflux.

Journal Article Pediatr Nephrol · February 2016 BACKGROUND: Primary vesicoureteral reflux (PVUR) is the most common malformation of the kidney and urinary tract, and reflux nephropathy is a major cause of chronic kidney disease in children. Recently, we reported mutations in the tenascin XB gene (TNXB) ... Full text Link to item Cite

Lower Urinary Tract Symptoms and Incontinence in Children with Pompe Disease.

Journal Article JIMD Rep · 2016 BACKGROUND: Pompe disease (PD) is a disorder of lysosomal glycogen storage. The introduction of enzyme replacement therapy (ERT) has shifted the focus of care from survival to quality of life. The presence of lower urinary tract symptoms (LUTS) and inconti ... Full text Link to item Cite

Medical expulsive therapy for pediatric urolithiasis: Systematic review and meta-analysis.

Journal Article J Pediatr Urol · December 2015 OBJECTIVE: Kidney stone disease has become more common among children and young adults. Despite its well-documented success in adults, published success rates of medical expulsive therapy (MET) for pediatric urolithiasis vary widely. Our objective was to d ... Full text Link to item Cite

Hospital Surgical Volume and Associated Postoperative Complications of Pediatric Urological Surgery in the United States.

Journal Article J Urol · August 2015 PURPOSE: Hospital and provider surgical volume have been increasingly linked to surgical outcomes. However, this topic has rarely been addressed in children. We investigated whether hospital surgical volume impacts complication rates in pediatric urology. ... Full text Link to item Cite

Factors associated with pressure ulcers in individuals with spina bifida.

Journal Article Arch Phys Med Rehabil · August 2015 OBJECTIVE: To describe factors associated with pressure ulcers in individuals with spina bifida (SB) enrolled in the National Spina Bifida Patient Registry (NSBPR). DESIGN: Unbalanced longitudinal multicenter cohort study. SETTING: Nineteen SB clinics. PAR ... Full text Link to item Cite

Estimating the nationwide, hospital based economic impact of pediatric urolithiasis.

Journal Article J Urol · May 2015 PURPOSE: The incidence of urolithiasis is increasing in children and adolescents but the economic impact of this problem is unclear. We examined 2 large databases to estimate the nationwide economic impact of pediatric urolithiasis. MATERIALS AND METHODS: ... Full text Link to item Cite

Neurogenic bladder dysfunction presenting as urinary retention in neuronopathic Gaucher disease.

Journal Article JIMD Rep · 2015 Neuronopathic Gaucher disease can present as a continuum of clinical findings, including somatic symptoms of anemia, thrombocytopenia, hepatosplenomegaly, and bone disease as well as neurologic sequelae. There is a spectrum of neurologic symptoms ranging f ... Full text Link to item Cite

Emergent care patterns in patients with spina bifida: a case-control study.

Journal Article J Urol · January 2015 PURPOSE: Individuals with spina bifida are typically followed closely as outpatients by multidisciplinary teams. However, emergent care of these patients is not well defined. We describe patterns of emergent care in patients with spina bifida and healthy c ... Full text Link to item Cite

Expanding our understanding of lower urinary tract symptoms and incontinence in adults with pompe disease.

Journal Article JIMD Rep · 2015 OBJECTIVE: To study the prevalence of lower urinary tract symptoms (LUTS) and incontinence in late-onset Pompe disease (LOPD) Methods: Adult LOPD patients seen at the Duke Pompe Clinic were prospectively recruited and asked to complete validated questionna ... Full text Link to item Cite

Estimating utility values for vesicoureteral reflux in the general public using an online tool.

Journal Article J Pediatr Urol · December 2014 INTRODUCTION: Cost-utility analyses are useful to study conditions without a widely accepted treatment algorithm; in pediatric urology, one such condition is vesicoureteral reflux (VUR). A necessary component of cost-utility analyses is to accurately calcu ... Full text Link to item Cite

COMBINATION PHARMACOTHERAPY FOR TREATMENT OF NEUROGENIC BLADDER

Conference NEUROUROLOGY AND URODYNAMICS · February 1, 2014 Link to item Cite

A novel method of teaching surgical techniques to residents--computerized enhanced visual learning (CEVL) with simulation to certify mastery of training: a model using newborn clamp circumcision.

Journal Article J Pediatr Urol · December 2013 OBJECTIVE: To assess the learning process of combining a web-based video of a simulated surgical procedure with a step-by-step checklist of the same procedure in achieving competency of the simulated technique, in this case a newborn clamp circumcision. Fu ... Full text Link to item Cite

Enhanced susceptibility to urinary tract infection in the spinal cord-injured host with neurogenic bladder.

Journal Article Infect Immun · August 2013 Neurogenic bladder predisposes to recurrent urinary tract infections (UTI) and renal failure, and susceptibility is commonly ascribed to urinary stasis from elevated residual urine volumes. Escherichia coli UTI was modeled in the spinal cord-injured (SCI) ... Full text Link to item Cite

TNXB mutations can cause vesicoureteral reflux.

Journal Article J Am Soc Nephrol · July 2013 Primary vesicoureteral reflux (VUR) is the most common congenital anomaly of the kidney and the urinary tract, and it is a major risk factor for pyelonephritic scarring and CKD in children. Although twin studies support the heritability of VUR, specific ge ... Full text Link to item Cite

Variation in definitions of urinary tract infections in spina bifida patients: a systematic review.

Journal Article Pediatrics · July 2013 OBJECTIVE: Urinary tract infections (UTIs) are a common source of morbidity among children with spina bifida (SB) and are a frequently reported outcome in studies of this patient population. However, the criteria for a diagnosis of UTI are often not stated ... Full text Link to item Cite

Partial orchiectomy for bilateral synchronous testicular masses in a prepubescent boy: a case report.

Journal Article Urology · November 2012 Featured Publication Testicular masses in prepubescent children are typically benign. Most masses are mature teratomas, epidermoid cysts, and stromal tumors. Synchronous bilateral testicular masses in children are rare. The etiology of these includes synchronous primary testic ... Full text Link to item Cite

How dry is dry? A review of definitions of continence in the contemporary exstrophy/epispadias literature.

Journal Article J Urol · November 2012 Featured Publication PURPOSE: Definitions of continence following surgery in children with exstrophy-epispadias complex vary widely. We assessed the most common definitions of continence and evaluated the clinical significance of usage patterns for those definitions. MATERIALS ... Full text Link to item Cite

EFFECTS OF SODIUM AND FRUCTOSE INTAKE ON PEDIATRIC STONE FORMATION

Conference JOURNAL OF ENDOUROLOGY · September 1, 2012 Link to item Cite

Bladder augmentation versus urinary diversion in patients with spina bifida in the United States.

Journal Article J Urol · July 2011 Featured Publication PURPOSE: Augmentation cystoplasty has replaced urinary diversion as the cornerstone of surgical management of refractory neurogenic bladder in patients with spina bifida. Other than single institution series little is known about practice patterns of bladd ... Full text Link to item Cite

Pediatric Urinary Tract Infections

Chapter · July 9, 2010 Management of UTIs in children is often different than in adults. Since many cannot easily give a urine specimen, urine collection can be problematic. Suprapubic aspiration from the bladder is best followed by urethral catheterization; bag collection and a ... Full text Cite

Editorial comment.

Other Urology · July 2010 Featured Publication Full text Link to item Cite

Prevalence of renal anomalies after urinary tract infections in hospitalized infants less than 2 months of age.

Journal Article J Perinatol · April 2010 Featured Publication OBJECTIVE: Our aim was to determine the incidence of anatomical abnormalities after a urinary tract infection (UTI) in infants <2 months of age hospitalized in the neonatal intensive care unit (NICU). STUDY DESIGN: This was a retrospective, single-center c ... Full text Open Access Link to item Cite

Purulent vaginal discharge secondary to ureteral ectopia.

Journal Article Clin Pediatr (Phila) · September 2009 Featured Publication Full text Link to item Cite

Voiding cystography practices and preferences of North American pediatric urologists.

Journal Article J Urol · July 2009 Featured Publication PURPOSE: Little consensus exists regarding the choice of a specific modality of voiding cystography in the evaluation and management of vesicoureteral reflux. We hypothesized that choices of pediatric urologists are based on technical factors of the studie ... Full text Link to item Cite

Evaluating outcomes of enterocystoplasty in patients with spina bifida: a review of the literature.

Journal Article J Urol · December 2008 Featured Publication PURPOSE: The urological complications of spina bifida impose a significant burden of disability and disease. Therapy is focused on the bladder to achieve the primary goals of maintaining normal renal function and attaining urinary continence. When medical ... Full text Link to item Cite

Endoscopic treatment: Who, when, and how?

Journal Article Contemporary Urology · August 1, 2007 Cite

Editorial Comment

Other Journal of Urology · October 1, 2006 Full text Cite

Editorial comment

Other Journal of Urology · June 1, 2006 Full text Cite

Intermittent testicular torsion.

Journal Article BJU Int · May 2005 Featured Publication Full text Link to item Cite

Aphallia with congenital urethrorectal fistula.

Journal Article Urology · February 2003 Featured Publication Full text Link to item Cite

Optimal timing of initial postnatal ultrasonography in newborns with prenatal hydronephrosis.

Journal Article J Urol · October 2002 Featured Publication PURPOSE: Conflicting data exist concerning optimal timing for initial postnatal ultrasound in newborns with prenatal hydronephrosis. To determine whether timing significantly affects the accuracy of postnatal ultrasound, we conducted a prospective study co ... Full text Link to item Cite

Genitourinary complications of sickle cell disease.

Journal Article J Urol · September 2001 Featured Publication PURPOSE: In the last half century the molecular biology, pathophysiology and natural history of sickle cell disease have been well defined. Sickle cell disease causes microvascular occlusion, which is manifested in most organ systems. The genitourinary tra ... Link to item Cite

Acute abdominal symptoms and signs in children and young adults with spina bifida: ten years' experience.

Journal Article J Pediatr Surg · September 2001 Featured Publication BACKGROUND/PURPOSE: Diagnosis and management of the acute abdomen in patients with spina bifida (SB) can be problematic. There are at least 4 clinical factors that can predispose to the development of acute abdominal symptoms and signs, and patients with a ... Full text Link to item Cite

Long-term efficacy of simple behavioral therapy for daytime wetting in children.

Journal Article J Urol · September 2000 Featured Publication PURPOSE: Behavioral therapy has proved benefit for children with daytime wetting but most studies have used biofeedback techniques and provide no long-term assessment of results. We previously reported similar results using simple behavioral therapy withou ... Full text Link to item Cite

Insights into causes of sexual ambiguity.

Journal Article Curr Opin Urol · November 1999 Our understanding of the causes of sexual ambiguity has progressed from the determination of the hormonal etiologies to defining the genetic basis of intersex disorders. The localization of specific genes involved in the process of sexual differentiation h ... Full text Link to item Cite

The incidence of nephrolithiasis in patients with spinal neural tube defects.

Journal Article J Urol · September 1999 PURPOSE: Bladder stones are common in patients with spinal neural tube defects but there are little data on the incidence of renal calculi in this population. We examined the incidence, nature and risk factors of nephrolithiasis in our clinic population of ... Full text Link to item Cite

Analysis of homeobox gene HOXA10 mutations in cryptorchidism.

Journal Article J Urol · January 1999 PURPOSE: Cryptorchidism is the most common congenital abnormality of the genitalia. However, its exact etiology remains to be defined. Homeobox (HOX) containing genes have a key role in the morphogenesis of segmental structures along the primary body axis, ... Link to item Cite

Androgen receptor gene alterations are not associated with isolated cryptorchidism.

Journal Article The Journal of urology · September 1998 PURPOSE: Multiple theories of testicular descent exist but there is no consensus. Cryptorchidism is a component of the androgen insensitivity syndrome, suggesting that testicular descent may be at least partially under the control of androgenic stimulation ... Cite

Outcome based comparison of surgical approaches for pediatric pyeloplasty: dorsal lumbar versus flank incision.

Journal Article J Urol · June 1998 PURPOSE: Dismembered pyeloplasty for the correction of ureteropelvic junction obstruction can be performed through a flank or dorsal lumbar incision. We compared the records of children who had undergone pyeloplasty by each approach to determine if 1 techn ... Full text Link to item Cite

Current concepts in the biology and management of Wilms tumor.

Journal Article J Urol · April 1998 PURPOSE: There have been a number of advances that have increased our understanding of the biology of Wilms tumor during the last decade. This information is now being incorporated into current pediatric oncology protocols. We present a summary of these ad ... Link to item Cite

Androgen gene mutation in hypospadias: a genetic and functional analysis

Other British Journal of Urology · December 1, 1997 Objective; Hypospadias has no known single etiology. Defects in the androgen receptor (AR) gene may result in partial or incomplete androgen insensitivity syndrome producing a spectrum of phenotypes including hypospsadias. We screened for AR gene mutations ... Cite

Laparoscopic management of persistent Müllerian duct remnants associated with an abdominal testis.

Journal Article J Endourol · October 1997 In recent years, laparoscopy has evolved from a purely diagnostic procedure in the management of nonpalpable testis to a definitive therapeutic intervention. Additional genital malformations occur in association with cryptorchidism, but reports of laparosc ... Full text Link to item Cite

Comparison of onlay and tubularized island flaps of inner preputial skin for the repair of proximal hypospadias.

Journal Article The Journal of urology · September 1997 PURPOSE: Transverse island flaps of inner preputial skin have provided a reliable technique for the repair of proximal hypospadias. The flap may be used to create a neourethra by tubularizing the flap after urethral transection or applying the flap as an o ... Cite

A renal size nomogram for the patient with myelomeningocele.

Journal Article The Journal of urology · September 1997 PURPOSE: Renal anatomy and function are usually monitored in the myelomeningocele population using routine ultrasound as the child grows. Clinical questions arise when a renal unit is of marginal size when evaluated with nomograms derived from normal patie ... Cite

Stent-free Thiersch-Duplay hypospadias repair with the Snodgrass modification.

Other J Urol · September 1997 PURPOSE: Incision of the glanular urethral plate (the Snodgrass modification) permits tubularization of the neourethra in the Thiersch-Duplay fashion when anatomy would otherwise preclude a tension-free anastomosis and necessitate another operative techniq ... Full text Link to item Cite

Molecular biology and function of the androgen receptor in genital development.

Journal Article J Urol · April 1997 PURPOSE: The rapidly growing field of molecular biology has caused exponential growth in our knowledge of the processes of embryogenesis. Since the cloning of the androgen receptor gene in 1988, investigators have been able to clarify many of the molecular ... Link to item Cite

Renal ultrasound changes after pyeloplasty in children with ureteropelvic junction obstruction: long-term outcome in 47 renal units.

Journal Article J Urol · December 1996 PURPOSE: We evaluated the use of renal ultrasound for monitoring pyelocaliectasis after pyeloplasty in children. MATERIALS AND METHODS: Changes in pyelocaliceal dilatation following pyeloplasty were assessed by serial ultrasound. Of 104 children 0 to 12 ye ... Link to item Cite

Androgen receptor gene mutations are rarely associated with isolated penile hypospadias.

Journal Article The Journal of urology · August 1996 PURPOSE: Hypospadias has no known single etiology but it has been linked to androgen insensitivity caused by mutations of the androgen receptor gene. The purpose of this study was to search for such mutations in cases of various degrees of isolated hypospa ... Cite

Molecular determinants of sexual differentiation.

Journal Article World J Urol · 1996 The processes of sexual differentiation have been greatly clarified by molecular biologic discoveries over the past five years. Gonadal differentiation into a testis or ovaries is controlled by a multitude of genes beginning with SRY which is believed to r ... Full text Link to item Cite

Intersex

Journal Article Current Opinion in Urology · January 1, 1996 Intersex often presents at birth with ambiguous genitalia but today can be diagnosed prenatally. The condition is the result of aberrant sexual differentiation - a complex process that involves the interplay of many genes recently identified by molecular b ... Full text Cite

Are modern imaging techniques over diagnosing ureteropelvic junction obstruction?

Journal Article J Urol · August 1995 Since the widespread use of real-time ultrasonography in the early 1980s, ureteropelvic junction obstruction has been diagnosed at earlier ages and prenatally on a presumptive basis. However, substantial controversy exists over the diagnosis and treatment ... Full text Link to item Cite

The association of oncogenic human papillomaviruses with urologic malignancy. The controversies and clinical implications.

Journal Article Surg Oncol Clin N Am · April 1995 Sexually transmitted human papillomaviruses (HPV) are linked to both benign and malignant lesions of the genitourinary tract. Evidence links oncogenic HPV types with carcinomas of the penis and urethra. An association with other common sites of urologic ma ... Link to item Cite

Oncogenic human papillomaviruses are rarely associated with squamous cell carcinoma of the bladder: evaluation by differential polymerase chain reaction.

Journal Article J Urol · February 1994 While a strong association between oncogenic human papillomaviruses and squamous cell cancers of the genital tract (penis, urethra and cervix) is known to exist, there is substantial controversy regarding the association of human papillomaviruses and cance ... Full text Link to item Cite

A high association of oncogenic human papillomaviruses with carcinomas of the female urethra: polymerase chain reaction-based analysis of multiple histological types.

Journal Article J Urol · January 1994 Using polymerase chain reaction with type-specific human papillomavirus type 16 and 18 primers, and general primers screening for 9 other genotypes, we analyzed archival surgical specimens of urethral carcinoma from 18 women (17 with invasive cancer and 1 ... Full text Link to item Cite

Squamous cell carcinoma of the prostate: 2 cases of a rare malignancy and review of the literature.

Journal Article J Urol · January 1993 Primary squamous cell carcinoma of the prostate is an extremely uncommon malignancy, accounting for less than 1% of all prostatic cancers. We report on 2 patients with primary squamous cell carcinoma of the prostate: 1 with organ-confined disease and 1 wit ... Full text Link to item Cite

Oncogenic human papillomavirus type 16 is associated with squamous cell cancer of the male urethra.

Journal Article Cancer Res · September 15, 1992 Human papillomaviruses (HPV), especially genotypes 16 and 18, are probable effectors of human urogenital malignancies. Although the male urethra is a proposed reservoir of HPV transmission, the association between HPV and squamous cell carcinoma (SCC) of t ... Link to item Cite

Interleukin-2-induced dermatotoxicity resembling toxic epidermal necrolysis.

Journal Article South Med J · June 1992 Interleukin-2 is a promising new immunotherapeutic antineoplastic agent, but it can cause severe multiorgan toxicity. Although dermatologic toxicity is seen in most patients receiving IL-2 therapy, it is usually manifested as pruritus and an erythematous m ... Full text Link to item Cite

Prevalence of human papillomavirus types 16 and 18 in squamous-cell carcinoma of the penis: a retrospective analysis of primary and metastatic lesions by differential polymerase chain reaction.

Journal Article Int J Cancer · March 12, 1992 Human papillomaviruses (HPV), particularly types 16 and 18, may be carcinogenic effectors in a variety of human lower-genital-tract malignancies. Using the highly sensitive technique of differential polymerase chain reaction (D-PCR) with amplimers from the ... Full text Link to item Cite