Kingshuk Roy Choudhury

Conference Journal of Lung, Pulmonary & Respiratory Research · December 30, 2020 Rationale: Recent advances in perfluoropropane magnetic resonance imaging of the lung have provided the means to assess pulmonary ventilation and gas distribution throughout the pulmonary airways and acini in a non-invasive manner. Objectives: The ... Full text Cite

Hepatobiliary phase hypointensity predicts progression to hepatocellular carcinoma for intermediate-high risk observations, but not time to progression.

Journal Article Eur J Radiol · July 2020 PURPOSE: To determine whether hepatobiliary phase hypointensity, enhancing "capsule" and size provide prognostic information regarding the risk of progression to hepatocellular carcinoma (HCC), as well as the time to progression, of intermediate to high ri ... Full text Link to item Cite

Long-term Evolution of Hepatocellular Adenomas at MRI Follow-up.

Journal Article Radiology · May 2020 Background Hepatocellular adenomas (HCAs) are rare benign liver tumors. Guidelines recommend continued surveillance of patients diagnosed with HCAs, but these guidelines are mainly based on small studies or expert opinion. Purpose To analyze the long-term ... Full text Link to item Cite

Influence of background lung characteristics on nodule detection with computed tomography.

Journal Article J Med Imaging (Bellingham) · March 2020 We sought to characterize local lung complexity in chest computed tomography (CT) and to characterize its impact on the detectability of pulmonary nodules. Forty volumetric chest CT scans were created by embedding between three and five simulated 5-mm lung ... Full text Link to item Cite

Impact of baseline covariate imbalance on bias in treatment effect estimation in cluster randomized trials: Race as an example.

Journal Article Contemp Clin Trials · January 2020 Individual-level baseline covariate imbalance could happen more frequently in cluster randomized trials, and may influence the observed treatment effect. Using computer and real-data simulations, this paper quantifies the extent and impact of covariate imb ... Full text Link to item Cite

Retrospective analysis of safety and efficacy of anti-PD-1 therapy and radiation therapy in advanced melanoma: A bi-institutional study.

Journal Article Radiother Oncol · September 2019 BACKGROUND AND PURPOSE: Antibodies against programmed cell death protein 1 (PD-1) are standard treatments for advanced melanoma. Palliative radiation therapy (RT) is commonly administered for this disease. Safety and optimal timing for this combination for ... Full text Link to item Cite

Bayesian modeling of the structural connectome for studying Alzheimer’s disease

Journal Article Annals of Applied Statistics · September 1, 2019 We study possible relations between Alzheimer’s disease progression and the structure of the connectome which is white matter connecting different regions of the brain. Regression models in covariates including age, gender and disease status for the extent ... Full text Cite

Automated Early Identification of an Excessive Air-in-Oil X-ray Tube Artifact That Mimics Acute Cerebral Infarct.

Journal Article J Comput Assist Tomogr · 2019 PURPOSE: This study aimed to develop an automated, quantitative method to increase the likelihood of identifying and preventing such air-in-oil (AIO) artifact. METHODS: A 1-dimensional radial representation of the 2-dimensional noise power spectrum (NPS) w ... Full text Link to item Cite

Geographic Access to CT for Lung Cancer Screening: A Census Tract-Level Analysis of Cigarette Smoking in the United States and Driving Distance to a CT Facility.

Journal Article J Am Coll Radiol · January 2019 PURPOSE: Spatial access to health care resources is a requisite for utilization. Our purpose was to determine, at a census tract level, the geographic distribution of US smokers and their driving distance to an ACR-accredited CT facility. METHODS: The numb ... Full text Link to item Cite

A Lamina-Associated Domain Border Governs Nuclear Lamina Interactions, Transcription, and Recombination of the Tcrb Locus.

Journal Article Cell Rep · November 13, 2018 Tcrb locus V(D)J recombination is regulated by positioning at the nuclear periphery. Here, we used DamID to profile Tcrb locus interactions with the nuclear lamina at high resolution. We identified a lamina-associated domain (LAD) border composed of severa ... Full text Link to item Cite

Local complexity metrics to quantify the effect of anatomical noise on detectability of lung nodules in chest CT imaging.

Journal Article J Med Imaging (Bellingham) · October 2018 The purpose of this study is to (1) develop metrics to characterize the regional anatomical complexity of the lungs, and (2) relate these metrics with lung nodule detection in chest CT. A free-scrolling reader-study with virtually inserted nodules (13 radi ... Full text Link to item Cite

Development and Preliminary Evaluation of a Murine Model of Chronic Radiation-Induced Proctitis.

Journal Article Int J Radiat Oncol Biol Phys · August 1, 2018 PURPOSE: Radiotherapy (RT) is commonly used to treat most pelvic malignancies. While treatment is often effective, curative radiation doses to the rectum can result in chronic radiation-induced proctitis, which is characterized by diarrhea, tenesmus, and/o ... Full text Link to item Cite

Application of a Novel Murine Ear Vein Model to Evaluate the Effects of a Vascular Radioprotectant on Radiation-Induced Vascular Permeability and Leukocyte Adhesion.

Journal Article Radiat Res · July 2018 Vascular injury after radiation exposure contributes to multiple types of tissue injury through a cascade of events. Some of the earliest consequences of radiation damage include increased vascular permeability and promotion of inflammation, which is parti ... Full text Link to item Cite

Effect of Transmit Beamforming on Clutter Levels in Transthoracic Echocardiography.

Journal Article Ultrason Imaging · July 2018 Transmit beamforming has a strong impact on several factors that govern image quality, field-of-view, and frame-rate in ultrasound imaging. For cardiac applications, the visualization of fine structures and the ability to track their motion is equally impo ... Full text Link to item Cite

Interchangeability between real and three-dimensional simulated lung tumors in computed tomography: an interalgorithm volumetry study.

Journal Article J Med Imaging (Bellingham) · July 2018 Using hybrid datasets consisting of patient-derived computed tomography (CT) images with digitally inserted computational tumors, we establish volumetric interchangeability between real and computational lung tumors in CT. Pathologically-confirmed malignan ... Full text Link to item Cite

Effectiveness of informational decision aids and a live donor financial assistance program on pursuit of live kidney transplants in African American hemodialysis patients.

Journal Article BMC Nephrol · May 3, 2018 BACKGROUND: African Americans have persistently poor access to living donor kidney transplants (LDKT). We conducted a small randomized trial to provide preliminary evidence of the effect of informational decision support and donor financial assistance inte ... Full text Link to item Cite

Clinical Utility of Fetal Short-Lag Spatial Coherence Imaging.

Journal Article Ultrasound Med Biol · April 2018 In this study, we evaluate the clinical utility of fetal short-lag spatial coherence (SLSC) imaging. Previous work has documented significant improvements in image quality with fetal SLSC imaging as quantified by measurements of contrast and contrast-to-no ... Full text Link to item Cite

Effect of Tumor Size on Risk of Metastatic Disease and Survival for Thyroid Cancer: Implications for Biopsy Guidelines.

Journal Article Thyroid · March 2018 BACKGROUND: In many risk-stratification systems, the decision to biopsy thyroid nodules is determined by their sonographic features and size. Nevertheless, even low-suspicion nodules are often biopsied at small size thresholds because it is assumed that la ... Full text Link to item Cite

Branch order regression for modeling brain vasculature.

Journal Article Med Phys · March 2018 PURPOSE: Many biological objects, including neuronal dendrites, blood vasculature, airways, phylogenetic trees, produce tree structured data. Current methods of analysis either ignore the complex structure of trees or use distance-based methods which limit ... Full text Link to item Cite

White Matter Changes Related to Subconcussive Impact Frequency during a Single Season of High School Football.

Journal Article AJNR Am J Neuroradiol · February 2018 BACKGROUND AND PURPOSE: The effect of exposing the developing brain of a high school football player to subconcussive impacts during a single season is unknown. The purpose of this pilot study was to use diffusion tensor imaging to assess white matter chan ... Full text Open Access Link to item Cite

Association between neoadjuvant chemoradiation and survival for patients with locally advanced rectal cancer.

Journal Article Colorectal Dis · December 2017 AIM: To examine the overall survival differences for the following neoadjuvant therapy modalities - no therapy, chemotherapy alone, radiation alone and chemoradiation - in a large cohort of patients with locally advanced rectal cancer. METHOD: Adults with ... Full text Link to item Cite

Differential response to exercise in claudin-low breast cancer.

Journal Article Oncotarget · November 24, 2017 Exposure to exercise following a breast cancer diagnosis is associated with reductions in the risk of recurrence. However, it is not known whether breast cancers within the same molecular-intrinsic subtype respond differently to exercise. Syngeneic mouse m ... Full text Open Access Link to item Cite

Optimizing window settings for improved presentation of virtual monoenergetic images in dual-energy computed tomography.

Journal Article Med Phys · November 2017 PURPOSE: Dual-energy computed tomography virtual monoenergetic imaging (VMI) at 40 keV exhibits superior contrast-to-noise ratio (CNR), although practicing radiologists do not consistently prefer it over VMI at 70 keV due to high perceivable noise. We hypo ... Full text Link to item Cite

Notice of Removal: Translation of fetal short-lag spatial coherence (SLSC) imaging into clinical practice: A pilot study

Conference IEEE International Ultrasonics Symposium, IUS · October 31, 2017 Fetal short-lag spatial coherence (SLSC) imaging has demonstrated 64-85% increases in CNR and 17-29% increases in contrast relative to conventional B-mode imaging. However, despite its proven technical efficacy, the viability of fetal SLSC in the clinical ... Full text Cite

Characterization of Small (< 4 cm) Focal Renal Lesions: Diagnostic Accuracy of Spectral Analysis Using Single-Phase Contrast-Enhanced Dual-Energy CT.

Journal Article AJR Am J Roentgenol · October 2017 OBJECTIVE: The purpose of this study is to determine whether single-phase contrast-enhanced dual-energy quantitative spectral analysis improves the accuracy of diagnosis of small (< 4.0 cm) renal lesions, compared with conventional single-energy attenuatio ... Full text Link to item Cite

Liver imaging reporting and data system category 4 observations in MRI: Risk factors predicting upgrade to category 5.

Journal Article J Magn Reson Imaging · September 2017 PURPOSE: To identify demographic and imaging features in magnetic resonance imaging (MRI) that are associated with upgrade of Liver Imaging Reporting and Data System (LI-RADS) category 4 (LR-4) observations to category 5 (LR-5), and to assess their effects ... Full text Link to item Cite

Effect of Radiation Dose Reduction and Reconstruction Algorithm on Image Noise, Contrast, Resolution, and Detectability of Subtle Hypoattenuating Liver Lesions at Multidetector CT: Filtered Back Projection versus a Commercial Model-based Iterative Reconstruction Algorithm.

Journal Article Radiology · September 2017 Purpose To determine the effect of radiation dose and iterative reconstruction (IR) on noise, contrast, resolution, and observer-based detectability of subtle hypoattenuating liver lesions and to estimate the dose reduction potential of the IR algorithm in ... Full text Link to item Cite

Characterization of Small Focal Renal Lesions: Diagnostic Accuracy with Single-Phase Contrast-enhanced Dual-Energy CT with Material Attenuation Analysis Compared with Conventional Attenuation Measurements.

Journal Article Radiology · September 2017 Purpose To determine whether single-phase contrast material-enhanced dual-energy material attenuation analysis improves the characterization of small (1-4 cm) renal lesions compared with conventional attenuation measurements by using histopathologic analys ... Full text Link to item Cite

Techniques for virtual lung nodule insertion: volumetric and morphometric comparison of projection-based and image-based methods for quantitative CT.

Journal Article Phys Med Biol · August 22, 2017 Virtual nodule insertion paves the way towards the development of standardized databases of hybrid CT images with known lesions. The purpose of this study was to assess three methods (an established and two newly developed techniques) for inserting virtual ... Full text Link to item Cite

Assessment of healthcare personnel knowledge of stroke care at a large referral hospital in sub-Saharan Africa - A survey based approach.

Journal Article J Clin Neurosci · August 2017 There is no published literature regarding sub-Saharan health-care providers' understanding of stroke management patterns. Understanding current stroke management knowledge is important in formulating future education opportunities for providers to optimiz ... Full text Link to item Cite

Subtype-Specific Radiation Response and Therapeutic Effect of FAS Death Receptor Modulation in Human Breast Cancer.

Journal Article Radiat Res · August 2017 Breast cancer is the most common malignancy diagnosed among women and represents a heterogeneous group of subtypes. Radiation therapy is a critical component of treatment for breast cancer patients. However, little is known about radiation response among t ... Full text Link to item Cite

Variations in the functional visual field for detection of lung nodules on chest computed tomography: Impact of nodule size, distance, and local lung complexity.

Journal Article Med Phys · July 2017 PURPOSE: To explore the characteristics that impact lung nodule detection by peripheral vision when searching for lung nodules on chest CT-scans. METHODS: This study was approved by the local IRB and is HIPAA compliant. A simulated primary (1°) target mass ... Full text Link to item Cite

Inhibition of the Continuum of Radiation-Induced Normal Tissue Injury by a Redox-Active Mn Porphyrin.

Journal Article Radiat Res · July 2017 Normal tissue damage after head and neck radiotherapy involves a continuum of pathologic events to the mucosa, tongue and salivary glands. We examined the radioprotective effects of MnBuOE, a redox-active manganese porphyrin, at three stages of normal tiss ... Full text Link to item Cite

Tcrd Rearrangement Redirects a Processive Tcra Recombination Program to Expand the Tcra Repertoire.

Journal Article Cell Rep · June 6, 2017 Adaptive immunity depends on diverse T cell receptor repertoires generated by variable, diversity, and joining (V[D]J) recombination. Here, we define the principles by which combinatorial diversity is generated in the murine Tcra repertoire. Tcra and Tcrd ... Full text Link to item Cite

Is carpal tunnel syndrome present in acute stroke patients? An investigative study using clinical and imaging screening tools.

Journal Article J Clin Neurosci · May 2017 Carpal tunnel syndrome (CTS) is known to develop post-stroke. Median nerve ultrasound (US) is an inexpensive, effective means of screening. In this prospective feasibility study, we compared the ability of the physical exam, the Boston Carpal Tunnel Questi ... Full text Link to item Cite

Inadvertent Intrafacet Injection during Lumbar Interlaminar Epidural Steroid Injection: A Comparison of CT Fluoroscopic and Conventional Fluoroscopic Guidance.

Journal Article AJNR Am J Neuroradiol · February 2017 BACKGROUND AND PURPOSE: Inadvertent intrafacet injection can occur during interlaminar epidural steroid injection, resulting in a false-positive loss of resistance and nontarget injection of medication. The purpose of this investigation was to compare the ... Full text Link to item Cite

Accuracy and variability of texture-based radiomics features of lung lesions across CT imaging conditions

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2017 Texture analysis for lung lesions is sensitive to changing imaging conditions but these effects are not well understood, in part, due to a lack of ground-truth phantoms with realistic textures. The purpose of this study was to explore the accuracy and vari ... Full text Cite

Development of local complexity metrics to quantify the effect of anatomical noise on detectability of lung nodules in chest CT imaging

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2017 The purpose of this study was to develop metrics of local anatomical complexity and compare them with detectability of lung nodules in CT. Data were drawn retrospectively from a published perception experiment in which detectability was assessed in cases e ... Full text Cite

Time-Dependent Changes in Dural Enhancement Associated With Spontaneous Intracranial Hypotension.

Journal Article AJR Am J Roentgenol · December 2016 OBJECTIVE: The objective of our study was to determine whether the presence of individual imaging signs of spontaneous intracranial hypotension (SIH) is correlated with increasing duration of headache symptoms. Of particular interest is the relationship of ... Full text Link to item Cite

Assessing task performance in FFDM, DBT, and synthetic mammography using uniform and anthropomorphic physical phantoms.

Journal Article Med Phys · October 2016 PURPOSE: The purpose of this study is to quantify the differences in detectability between full field digital mammography (FFDM), digital breast tomosynthesis (DBT), and synthetic mammography (SM) for challenging, low contrast signals, in the context of bo ... Full text Link to item Cite

Natural history of liver imaging reporting and data system category 4 nodules in MRI.

Journal Article Abdom Radiol (NY) · September 2016 PURPOSE: The purpose of this study was to characterize the MR imaging features and outcomes of liver imaging reporting and data system (LI-RADS) category 4 (LR4) nodules, with an emphasis on upgrade to category 5 (LR5) and development of contraindications ... Full text Link to item Cite

The analytical change in plasma creatinine that constitutes a biologic/physiologic change.

Journal Article Clin Chim Acta · August 1, 2016 PURPOSE: Accurate and precise measurements of creatinine are necessary to evaluate changes in kidney function related to a decreased glomerular filtration rate (GFR). When serial measurements of creatinine are monitored in an individual, it is useful to kn ... Full text Link to item Cite

Diagnostic performance of MDCT in identifying closed loop small bowel obstruction.

Journal Article Abdom Radiol (NY) · July 2016 PURPOSE: To assess the diagnostic performance of MDCT in the diagnosis of closed loop small bowel obstruction. MATERIALS AND METHODS: One hundred fifty patients with CT reports including "small bowel obstruction (SBO)" between 1/30/2011 and 12/4/2012 were ... Full text Link to item Cite

Imaging Signs in Spontaneous Intracranial Hypotension: Prevalence and Relationship to CSF Pressure.

Journal Article AJNR Am J Neuroradiol · July 2016 BACKGROUND AND PURPOSE: Patients with spontaneous intracranial hypotension often exhibit low CSF pressure and changes on brain MR imaging and/or evidence of CSF leak on myelography. We investigated whether individual imaging signs of spontaneous intracrani ... Full text Link to item Cite

Classification of polyhedral shapes from individual anisotropically resolved cryo-electron tomography reconstructions.

Journal Article BMC Bioinformatics · June 13, 2016 BACKGROUND: Cryo-electron tomography (cryo-ET) enables 3D imaging of macromolecular structures. Reconstructed cryo-ET images have a "missing wedge" of data loss due to limitations in rotation of the mounting stage. Most current approaches for structure det ... Full text Link to item Cite

Neurobehavioral radiation mitigation to standard brain cancer therapy regimens by Mn(III) n-butoxyethylpyridylporphyrin-based redox modifier.

Journal Article Environ Mol Mutagen · June 2016 Combinations of radiotherapy (RT) and chemotherapy have shown efficacy toward brain tumors. However, therapy-induced oxidative stress can damage normal brain tissue, resulting in both progressive neurocognitive loss and diminished quality of life. We have ... Full text Link to item Cite

A Therapeutic Antibody for Cancer, Derived from Single Human B Cells.

Journal Article Cell Rep · May 17, 2016 Some patients with cancer never develop metastasis, and their host response might provide cues for innovative treatment strategies. We previously reported an association between autoantibodies against complement factor H (CFH) and early-stage lung cancer. ... Full text Open Access Link to item Cite

Difference in appearance between prone and supine myocardial perfusion images obtained on a high-efficiency cadmium zinc telluride SPECT camera.

Journal Article Nucl Med Commun · May 2016 OBJECTIVE: The recent introduction of high-efficiency solid-state gamma cameras for myocardial perfusion single photon emission computed tomography has enabled lower patient radiation dose, faster imaging, and improved image quality. However, artifacts sti ... Full text Link to item Cite

Virtual Monochromatic Images from Dual-Energy Multidetector CT: Variance in CT Numbers from the Same Lesion between Single-Source Projection-based and Dual-Source Image-based Implementations.

Journal Article Radiology · April 2016 PURPOSE: To determine the variance in virtual monochromatic computed tomography (CT) numbers from the same lesion, comparing the two clinically available dual-energy multidetector CT hardware implementations (single-source projection-based and dual-source ... Full text Link to item Cite

Quantitative Features of Liver Lesions, Lung Nodules, and Renal Stones at Multi-Detector Row CT Examinations: Dependency on Radiation Dose and Reconstruction Algorithm.

Journal Article Radiology · April 2016 PURPOSE: To determine if radiation dose and reconstruction algorithm affect the computer-based extraction and analysis of quantitative imaging features in lung nodules, liver lesions, and renal stones at multi-detector row computed tomography (CT). MATERIA ... Full text Link to item Cite

Correction: Leishmania donovani Infection Enhances Lateral Mobility of Macrophage Membrane Protein Which Is Reversed by Liposomal Cholesterol.

Journal Article PLoS Negl Trop Dis · April 2016 Full text Link to item Cite

The Alzheimer Structural Connectome: Changes in Cortical Network Topology with Increased Amyloid Plaque Burden.

Journal Article Radiology · April 2016 Full text Link to item Cite

Effects of automatic tube potential selection on radiation dose index, image quality, and lesion detectability in pediatric abdominopelvic CT and CTA: a phantom study.

Journal Article Eur Radiol · January 2016 OBJECTIVES: To assess the effect of automatic tube potential selection (ATPS) on radiation dose, image quality, and lesion detectability in paediatric abdominopelvic CT and CT angiography (CTA). METHODS: A paediatric modular phantom with contrast inserts w ... Full text Link to item Cite

Novel Manganese-Porphyrin Superoxide Dismutase-Mimetic Widens the Therapeutic Margin in a Preclinical Head and Neck Cancer Model.

Journal Article Int J Radiat Oncol Biol Phys · November 15, 2015 PURPOSE: To test the effects of a novel Mn porphyrin oxidative stress modifier, Mn(III) meso-tetrakis(N-n-butoxyethylpyridinium-2-yl)porphyrin (MnBuOE), for its radioprotective and radiosensitizing properties in normal tissue versus tumor, respectively. ME ... Full text Open Access Link to item Cite

Effect of radiologists' experience with an adaptive statistical iterative reconstruction algorithm on detection of hypervascular liver lesions and perception of image quality.

Journal Article Abdom Imaging · October 2015 PURPOSE: To prospectively evaluate whether clinical experience with an adaptive statistical iterative reconstruction algorithm (ASiR) has an effect on radiologists' diagnostic performance and confidence for the diagnosis of hypervascular liver tumors, as w ... Full text Link to item Cite

Minimally Invasive Distal Pancreatectomy for Cancer: Short-Term Oncologic Outcomes in 1,733 Patients.

Journal Article World J Surg · October 2015 BACKGROUND: Data from high-volume institutions suggest that minimally invasive distal pancreatectomy (MIDP) provides favorable perioperative outcomes and adequate oncologic resection for pancreatic cancer; however, these outcomes may not be generalizable. ... Full text Link to item Cite

Diagnostic performance of imaging criteria for distinguishing autoimmune cholangiopathy from primary sclerosing cholangitis and bile duct malignancy.

Journal Article Abdom Imaging · October 2015 OBJECTIVE: To determine the diagnostic performance of imaging criteria for distinguishing Ig-G4-associated autoimmune cholangiopathy (IAC) from primary sclerosing cholangitis (PSC) and bile duct malignancy. METHODS: A medical records search between January ... Full text Link to item Cite

High-Pitch Dual-Source MDCT for Imaging of the Thoracoabdominal Aorta: Relationships Among Radiation Dose, Noise, Pitch, and Body Size in a Phantom Experiment and Clinical Study.

Journal Article AJR Am J Roentgenol · October 2015 OBJECTIVE: The purpose of this study was to investigate, both in a phantom experiment and a within-patient clinical study the relationships among radiation dose, image noise, pitch, and body size in MDCT angiography of the thoracoabdominal aorta, with the ... Full text Link to item Cite

Marked gender differences in progression of mild cognitive impairment over 8 years.

Journal Article Alzheimers Dement (N Y) · September 1, 2015 INTRODUCTION: This study examined whether, among subjects with mild cognitive impairment (MCI), women progressed at faster rates than men. METHODS: We examine longitudinal rates of change from baseline in 398 MCI subjects (141 Females, 257 Males) in the Al ... Full text Link to item Cite

Minimally Invasive Versus Open Pancreaticoduodenectomy for Cancer: Practice Patterns and Short-term Outcomes Among 7061 Patients.

Journal Article Ann Surg · August 2015 OBJECTIVES: To describe national practice patterns regarding utilization of minimally invasive pancreaticoduodenectomy (MIPD) and compare short-term outcomes with those following open pancreaticoduodenectomy for cancer. BACKGROUND: There is increasing inte ... Full text Link to item Cite

Dynamic treatment effect (DTE) curves reveal the mode of action for standard and experimental cancer therapies.

Journal Article Oncotarget · June 10, 2015 We present a method for estimating the empirical dynamic treatment effect (DTE) curves from tumor growth delay (TGD) studies. This improves on current common methods of TGD analysis, such as T/C ratio and doubling times, by providing a more detailed treatm ... Full text Link to item Cite

Precision cancer immunotherapy: optimizing dendritic cell-based strategies to induce tumor antigen-specific T-cell responses against individual patient tumors.

Journal Article J Immunother · May 2015 Most dendritic cell (DC)-based vaccines have loaded the DC with defined antigens, but loading with autologos tumor-derived antigens would generate DCs that activate personalized tumor-specific T-cell responses. We hypothesized that DC matured with an optim ... Full text Link to item Cite

Meta-analysis of the technical performance of an imaging procedure: guidelines and statistical methodology.

Journal Article Stat Methods Med Res · February 2015 Medical imaging serves many roles in patient care and the drug approval process, including assessing treatment response and guiding treatment decisions. These roles often involve a quantitative imaging biomarker, an objectively measured characteristic of t ... Full text Link to item Cite

The emerging science of quantitative imaging biomarkers terminology and definitions for scientific studies and regulatory submissions.

Journal Article Stat Methods Med Res · February 2015 The development and implementation of quantitative imaging biomarkers has been hampered by the inconsistent and often incorrect use of terminology related to these markers. Sponsored by the Radiological Society of North America, an interdisciplinary group ... Full text Open Access Link to item Cite

Radiology reports for incidental thyroid nodules on CT and MRI: high variability across subspecialties.

Journal Article AJNR Am J Neuroradiol · February 2015 BACKGROUND AND PURPOSE: Variability in radiologists' reporting styles and recommendations for incidental thyroid nodules can lead to confusion among clinicians and may contribute to inconsistent patient care. Our aim was to describe reporting practices of ... Full text Link to item Cite

Dual-energy multidetector CT for the characterization of incidental adrenal nodules: diagnostic performance of contrast-enhanced material density analysis.

Journal Article Radiology · February 2015 PURPOSE: To determine whether contrast material-enhanced dual-energy multidetector computed tomography (CT) with material decomposition analysis allows differentiation of adrenal adenomas from nonadenomatous lesions and to compare findings with those of no ... Full text Link to item Cite

Detection of prostate cancer with multiparametric MRI (mpMRI): effect of dedicated reader education on accuracy and confidence of index and anterior cancer diagnosis.

Journal Article Abdom Imaging · January 2015 PURPOSE: To evaluate the impact of dedicated reader education on accuracy/confidence of peripheral zone index cancer and anterior prostate cancer (PCa) diagnosis with mpMRI; secondary aim was to assess the ability of readers to differentiate low-grade canc ... Full text Link to item Cite

Characterizing search, recognition, and decision in the detection of lung nodules on CT scans: elucidation with eye tracking.

Journal Article Radiology · January 2015 PURPOSE: To determine the effectiveness of radiologists' search, recognition, and acceptance of lung nodules on computed tomographic (CT) images by using eye tracking. MATERIALS AND METHODS: This study was performed with a protocol approved by the institut ... Full text Link to item Cite

Educational attainment and hippocampal atrophy in the Alzheimer's disease neuroimaging initiative cohort.

Journal Article J Neuroradiol · December 2014 INTRODUCTION: Subjects with higher cognitive reserve (CR) may be at a lower risk for Alzheimer's disease (AD), but the neural mechanisms underlying this are not known. Hippocampal volume loss is an early event in AD that triggers cognitive decline. MATERIA ... Full text Link to item Cite

Dual-energy MDCT in hypervascular liver tumors: effect of body size on selection of the optimal monochromatic energy level.

Journal Article AJR Am J Roentgenol · December 2014 OBJECTIVE: The purpose of this article is to investigate the effect of body size on the selection of optimal monochromatic energy level for maximizing the conspicuity of hypervascular liver tumors during late hepatic arterial phase using dual-energy MDCT. ... Full text Link to item Cite

Leishmania donovani infection enhances lateral mobility of macrophage membrane protein which is reversed by liposomal cholesterol.

Journal Article PLoS Negl Trop Dis · December 2014 BACKGROUND: The protozoan parasite Leishmania donovani (LD) reduces cellular cholesterol of the host possibly for its own benefit. Cholesterol is mostly present in the specialized compartment of the plasma membrane. The relation between mobility of membran ... Full text Link to item Cite

Diffusion-weighted imaging for head and neck squamous cell carcinoma: quantifying repeatability to understand early treatment-induced change.

Journal Article AJR Am J Roentgenol · November 2014 OBJECTIVE: The purpose of this study was to define baseline variability of apparent diffusion coefficient (ADC) on diffusion-weighted MR imaging (DWI) in patients with head and neck squamous cell carcinoma (HNSCC) and to compare it with early treatment-ind ... Full text Link to item Cite

Automated characterization of perceptual quality of clinical chest radiographs: validation and calibration to observer preference.

Journal Article Med Phys · November 2014 PURPOSE: The authors previously proposed an image-based technique [Y. Lin et al. Med. Phys. 39, 7019-7031 (2012)] to assess the perceptual quality of clinical chest radiographs. In this study, an observer study was designed and conducted to validate the ou ... Full text Link to item Cite

The Alzheimer structural connectome: changes in cortical network topology with increased amyloid plaque burden.

Journal Article Radiology · October 2014 PURPOSE: To evaluate differences in the structural connectome among patients with normal cognition (NC), mild cognitive impairment (MCI), and Alzheimer disease (AD) and to determine associations between the structural connectome and cortical amyloid deposi ... Full text Link to item Cite

Dual-energy multi-detector row CT with virtual monochromatic imaging for improving patient-to-patient uniformity of aortic enhancement during CT angiography: an in vitro and in vivo study.

Journal Article Radiology · September 2014 PURPOSE: To determine whether virtual monochromatic imaging from a dual-energy acquisition can improve patient-to-patient uniformity of aortic enhancement during multi-detector row computed tomographic (CT) angiography. MATERIALS AND METHODS: This retrospe ... Full text Link to item Cite

Impact of dual-energy multi-detector row CT with virtual monochromatic imaging on renal cyst pseudoenhancement: in vitro and in vivo study.

Journal Article Radiology · September 2014 PURPOSE: To investigate whether dual-energy multi-detector row computed tomography (CT) with virtual monochromatic imaging can overcome renal cyst pseudoenhancement in a phantom experiment and a clinical study. MATERIALS AND METHODS: This retrospective sin ... Full text Link to item Cite

Trends in incidentally identified thyroid cancers over a decade: a retrospective analysis of 2,090 surgical patients.

Journal Article World J Surg · June 2014 BACKGROUND: The aim of this study was to describe trends in the incidence of incidental thyroid cancers and compare their characteristics with clinically presenting cancers. METHODS: We performed a retrospective review of patients with thyroid cancer who u ... Full text Link to item Cite

Coil embolization of the splenic artery: impact on splenic volume.

Journal Article J Vasc Interv Radiol · June 2014 PURPOSE: To determine the impact of coil embolization of the splenic artery on splenic volume based on computed tomography (CT) imaging. MATERIALS AND METHODS: Splenic artery embolization (SAE) was performed in 148 consecutive patients over an 8-year perio ... Full text Link to item Cite

Mapping the effect of the apolipoprotein E genotype on 4-year atrophy rates in an Alzheimer disease-related brain network.

Journal Article Radiology · April 2014 PURPOSE: To determine the effect of the apolipoprotein E (APOE) genotype on atrophy rates of specific brain gray matter regions hypothesized to be key components of cognitive networks disrupted in Alzheimer disease. MATERIALS AND METHODS: The Alzheimer's D ... Full text Link to item Cite

An exponential growth in incidence of thyroid cancer: trends and impact of CT imaging.

Journal Article AJNR Am J Neuroradiol · April 2014 BACKGROUND AND PURPOSE: Workup of incidental thyroid nodules detected on CT imaging could be contributing to the increased diagnosis of small thyroid cancers. The purpose of this study was to evaluate recent trends in the incidence of thyroid cancer, and t ... Full text Link to item Cite

An analysis of the uncertainty and bias in DCE-MRI measurements using the spoiled gradient-recalled echo pulse sequence.

Journal Article Med Phys · March 2014 PURPOSE: The pharmacokinetic parameters derived from dynamic contrast-enhanced (DCE) MRI have been used in more than 100 phase I trials and investigator led studies. A comparison of the absolute values of these quantities requires an estimation of their re ... Full text Link to item Cite

Prevalence of the polar vessel sign in parathyroid adenomas on the arterial phase of 4D CT.

Journal Article AJNR Am J Neuroradiol · March 2014 BACKGROUND AND PURPOSE: The "polar vessel" sign has been previously described on sonography of parathyroid adenomas. We estimated the 4D CT prevalence of the polar vessel sign and determined features of parathyroid adenomas that are associated with this si ... Full text Link to item Cite

Computed tomography findings in liver fibrosis and cirrhosis.

Journal Article Swiss Med Wkly · February 19, 2014 PRINCIPLES: Computed tomography (CT) is inferior to the fibroscan and laboratory testing in the noninvasive diagnosis of liver fibrosis. On the other hand, CT is a frequently used diagnostic tool in modern medicine. The auxiliary finding of clinically occu ... Full text Link to item Cite

Validation of an image-based technique to assess the perceptual quality of clinical chest radiographs with an observer study

Journal Article Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2014 We previously proposed a novel image-based quality assessment technique1 to assess the perceptual quality of clinical chest radiographs. In this paper, an observer study was designed and conducted to systematically validate this technique. Ten metrics were ... Full text Cite

Brain atrophy rates in first degree relatives at risk for Alzheimer's.

Journal Article Neuroimage Clin · 2014 A positive family history (FH) raises the risk for late-onset Alzheimer's disease though, other than the known risk conferred by apolipoprotein ε4 (ApoE4), much of the genetic variance remains unexplained. We examined the effect of family history on longit ... Full text Link to item Cite

Clinical impact of an adaptive statistical iterative reconstruction algorithm for detection of hypervascular liver tumours using a low tube voltage, high tube current MDCT technique.

Journal Article Eur Radiol · December 2013 OBJECTIVES: To investigate the impact of an adaptive statistical iterative reconstruction (ASiR) algorithm on diagnostic accuracy and confidence for the diagnosis of hypervascular liver tumours, as well as the reader's perception of image quality, using a ... Full text Link to item Cite

Bone marrow biopsy: RNA isolation with expression profiling in men with metastatic castration-resistant prostate cancer--factors affecting diagnostic success.

Journal Article Radiology · December 2013 PURPOSE: To determine the rate at which computed tomographically guided pelvic percutaneous bone biopsy in men with metastatic castration-resistant prostate cancer (mCRPC) yields adequate tissue for genomic profiling and to identify issues likely to affect ... Full text Link to item Cite

Peripheral subnuclear positioning suppresses Tcrb recombination and segregates Tcrb alleles from RAG2.

Journal Article Proc Natl Acad Sci U S A · November 26, 2013 Allelic exclusion requires that the two alleles at antigen-receptor loci attempt to recombine variable (V), diversity (D), and joining (J) gene segments [V(D)J recombination] asynchronously in nuclei of developing lymphocytes. It previously was shown that ... Full text Link to item Cite

Erratum: CT patterns of fungal pulmonary infections of the lung: Comparison of standard-dose and simulated low-dose CT (European Journal of Radiology (2012) 81 (2860-2866))

Journal Article European Journal of Radiology · November 1, 2013 Full text Cite

Incidental thyroid nodules on CT: evaluation of 2 risk-categorization methods for work-up of nodules.

Journal Article AJNR Am J Neuroradiol · September 2013 BACKGROUND AND PURPOSE: Thyroid nodules are common incidental findings on CT, but there are no clear guidelines regarding their further diagnostic work-up. This study compares the performance of 2 risk-categorization methods of selecting CT-detected incide ... Full text Link to item Cite

Mapping the effects of ApoE4, age and cognitive status on 18F-florbetapir PET measured regional cortical patterns of beta-amyloid density and growth.

Journal Article Neuroimage · September 2013 BACKGROUND: Although it is well known that many clinical and genetic factors have been associated with beta-amyloid deposition, few studies have examined the interactions of such factors across different stages of Alzheimer's pathogenesis. METHODS: We used ... Full text Link to item Cite

Effective DQE (eDQE) for monoscopic and stereoscopic chest radiography imaging systems with the incorporation of anatomical noise.

Journal Article Med Phys · September 2013 PURPOSE: Stereoscopic chest biplane correlation imaging (stereo∕BCI) has been proposed as an alternative modality to single view chest x-ray (CXR). The metrics effective modulation transfer function (eMTF), effective normalized noise power spectrum (eNNPS) ... Full text Link to item Cite

Impact of image quality, radiologists, lung segments, and Gunnar eyewear on detectability of lung nodules in chest CT.

Journal Article Acta Radiol · July 2013 BACKGROUND: Despite the increasingly higher spatial and contrast resolution of CT, nodular lesions are prone to be missed on chest CT. Tinted lenses increase visual acuity and contrast sensitivity by filtering short wavelength light of solar and artificial ... Full text Link to item Cite

Using FDG-PET to measure early treatment response in head and neck squamous cell carcinoma: quantifying intrinsic variability in order to understand treatment-induced change.

Journal Article AJNR Am J Neuroradiol · July 2013 BACKGROUND AND PURPOSE: Quantification of both baseline variability and intratreatment change is necessary to optimally incorporate functional imaging into adaptive therapy strategies for HNSCC. Our aim was to define the baseline variability of SUV on FDG- ... Full text Link to item Cite

Does the preparation and utilization of 99mTc-sulfur colloid affect the outcomes of breast lymphoscintigraphy?

Journal Article J Nucl Med Technol · June 2013 UNLABELLED: The purpose of this study was to determine whether certain factors in the preparation and use of (99m)Tc-sulfur colloid affected the number of sentinel lymph nodes (SLNs) detected during SLN mapping and during intraoperative SLN identification. ... Full text Link to item Cite

Accuracy of low-dose computed tomography (CT) for detecting and characterizing the most common CT-patterns of pulmonary disease.

Journal Article Eur J Radiol · March 2013 PURPOSE: To assess the ability of low-dose CT to detect and characterize the most common CT patterns of pulmonary disease. METHODS AND MATERIALS: Sixty patients with nodules, consolidations or interstitial disease were scanned using a low-dose (128 mm × 0. ... Full text Link to item Cite

Predicting cognitive decline in subjects at risk for Alzheimer disease by using combined cerebrospinal fluid, MR imaging, and PET biomarkers.

Journal Article Radiology · February 2013 PURPOSE: To assess the extent to which multiple Alzheimer disease (AD) biomarkers improve the ability to predict future decline in subjects with mild cognitive impairment (MCI) compared with predictions based on clinical parameters alone. MATERIALS AND MET ... Full text Link to item Cite

A cautionary note on the use of positivity constrained reconstructions for quantification of regional PET imaging data

Conference IEEE Nuclear Science Symposium Conference Record · January 1, 2013 Positively constrained maximum likelihood (ML) reconstructions in PET eliminate the negative values associated with unconstrained least squares (LS) - more commonly known as filtered back-projection (FBP). This is desirable for certain qualitative imaging ... Full text Cite

Dissecting the gene dose-effects of the APOE ε4 and ε2 alleles on hippocampal volumes in aging and Alzheimer's disease.

Journal Article PLoS One · 2013 OBJECTIVE: To investigate whether there is a specific dose-dependent effect of the Apolipoprotein E (APOE) ε4 and ε2 alleles on hippocampal volume, across the cognitive spectrum, from normal aging to Alzheimer's Disease (AD). MATERIALS AND METHODS: We anal ... Full text Link to item Cite

Prevalence of Alzheimer's pathologic endophenotypes in asymptomatic and mildly impaired first-degree relatives.

Journal Article PLoS One · 2013 OBJECTIVE: A positive family history (FH) is a risk factor for late-onset Alzheimer's disease (AD). Our aim was to examine the effects of FH on pathological and neuronal loss biomarkers across the cognitive spectrum. DESIGN: Cross-sectional analyses of dat ... Full text Link to item Cite

A comparison of least squares and conditional maximum likelihood estimators under volume endpoint censoring in tumor growth experiments.

Journal Article Stat Med · December 20, 2012 Measurements in tumor growth experiments are stopped once the tumor volume exceeds a preset threshold: a mechanism we term volume endpoint censoring. We argue that this type of censoring is informative. Further, least squares (LS) parameter estimates are s ... Full text Link to item Cite

CT-guided lumbar nerve root injections: are we using the correct radiation dose settings?

Journal Article AJNR Am J Neuroradiol · November 2012 BACKGROUND AND PURPOSE: Selecting a lower tube current for CT fluoroscopic spine injections is a method of radiation dose reduction. Ideally tube current should be tailored to the patient's body habitus, but a greater influence on tube current may be the p ... Full text Link to item Cite

Observation of dually decoded regions of the human genome using ribosome profiling data.

Journal Article Genome Res · November 2012 The recently developed ribosome profiling technique (Ribo-Seq) allows mapping of the locations of translating ribosomes on mRNAs with subcodon precision. When ribosome protected fragments (RPFs) are aligned to mRNA, a characteristic triplet periodicity pat ... Full text Link to item Cite

CT patterns of fungal pulmonary infections of the lung: comparison of standard-dose and simulated low-dose CT.

Journal Article Eur J Radiol · October 2012 PURPOSE: To assess the effect of radiation dose reduction on the appearance and visual quantification of specific CT patterns of fungal infection in immuno-compromised patients. MATERIALS AND METHODS: Raw data of thoracic CT scans (64 × 0.75 mm, 120 kVp, 3 ... Full text Link to item Cite

Quantification of Tc-99m sestamibi distribution in normal breast tissue using dedicated breast SPECT-CT

Journal Article Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) · August 15, 2012 The use of Tc-99m-Sestamibi in molecular breast imaging is common due to its preferential uptake in malignant tissue. However, quantification of the baseline uptake in normal, healthy breast tissue is not possible using planar-imaging devices. Using our de ... Full text Cite

Reproducible research in medical imaging.

Journal Article Mol Imaging Biol · August 2012 Full text Link to item Cite

SU-E-T-275: Dose Verification in a Small Animal Image-Guided Radiation Therapy X-Ray Machine: A Dose Comparison between TG-61 Based Look-Up Table and MOSFET Method for Various Collimator Sizes.

Journal Article Med Phys · June 2012 PURPOSE: To verify the accuracy of TG-61 based dosimetry with MOSFET technology using a tissue-equivalent mouse phantom. METHODS: Accuracy of mouse dose between a TG-61 based look-up table was verified with MOSFET technology. The look-up table followed a T ... Full text Link to item Cite

SU-E-I-47: Comparison of Risks for Two Medical Imaging Procedures.

Journal Article Med Phys · June 2012 PURPOSE: Radiologists may need to decide which type of image procedure is most appropriate for a particular patient. One factor relevant in making this decision is the relative risk of secondary cancers due to each relevant procedure. Differences in the ri ... Full text Link to item Cite

Organ-based dose current modulation and thyroid shields: techniques of radiation dose reduction for neck CT.

Journal Article AJR Am J Roentgenol · May 2012 OBJECTIVE: The purpose of this study was to assess the difference in absorbed organ dose and image quality for MDCT neck protocols using automatic tube current modulation alone compared with organ-based dose modulation and in-plane thyroid bismuth shieldin ... Full text Link to item Cite

Variation in tube voltage for adult neck MDCT: effect on radiation dose and image quality.

Journal Article AJR Am J Roentgenol · March 2012 OBJECTIVE: The purpose of this study was to assess the effect of peak kilovoltage on radiation dose and image quality in adult neck MDCT. MATERIALS AND METHODS: An anthropomorphic phantom with metal oxide semiconductor field effect transistor detectors was ... Full text Link to item Cite

Accuracy of a remote eye tracker for radiologic observer studies: effects of calibration and recording environment.

Journal Article Acad Radiol · February 2012 RATIONALE AND OBJECTIVES: To determine the accuracy and reproducibility of a remote eye-tracking system for studies of observer gaze while displaying volumetric chest computed tomography (CT) images. MATERIALS AND METHODS: Four participants performed calib ... Full text Link to item Cite

WE‐A‐217A‐02: The Impact of Fluorodeoxyglucose Positron Emission Tomography (FDG‐PET) Variability on the Assessment of Treatment Response in Head‐And‐Neck Cancer Patients Undergoing Chemoradiotherapy

Conference Medical Physics · January 1, 2012 Purpose: To compare intrinsic, temporal variability of tumor glucose metabolism versus early treatment‐induced change. This assessment is necessary to use changes in imaging parameters during therapy to properly segregate metabolic responders from non‐resp ... Full text Cite

Parametric scalp mapping and inference via spatially smooth linear models for mismatch negativity studies

Journal Article Journal of Statistical Planning and Inference · January 1, 2012 Mismatch negativity (MMN) is a neurophysiological tool that can be used to investigate various facets of comprehension. Subjects are presented with different stimuli to elicit the MMN response, which is derived from electroencephalography (EEG) signals rec ... Full text Cite

Intra subject variation and correlation of motor potentials evoked by transcranial magnetic stimulation.

Journal Article Ir J Med Sci · December 2011 Featured Publication BACKGROUND: Characterising intra and inter-subject variability of motor-evoked potential (MEP) measurements from transcranial magnetic stimulation (TMS) is key to its development as a diagnostic tool. METHODS: We performed three experiments to elucidate ME ... Full text Link to item Cite

Revival of Seeliger's historical 'Special Listeria Culture Collection'.

Journal Article Environ Microbiol · December 2011 The recent evolution of bacterial species can be elucidated with the aid of large historical strain collections. Unfortunately, information for some of these strain collections is not publicly available, or only in a format which is not readily digitized. ... Full text Link to item Cite

CT screening and follow-up of lung nodules: effects of tube current-time setting and nodule size and density on detectability and of tube current-time setting on apparent size.

Journal Article AJR Am J Roentgenol · September 2011 Featured Publication OBJECTIVE: The purpose of the study was to quantify and compare the effect of CT dose and of size and density of nodules on the detectability of lung nodules and to quantify the influence of CT dose on the size of the nodules. MATERIALS AND METHODS: From 5 ... Full text Link to item Cite

Analysis of total aerobic viable counts in raw fish by high-throughput optical oxygen respirometry.

Journal Article J Food Prot · May 2011 A simple, miniaturized, and automated screening assay for the determination of total aerobic viable counts in fish samples is presented here. Fish tissue homogenates were prepared in peptone buffered water medium, according to standard method, and aliquots ... Full text Link to item Cite

Human visceral leishmaniasis: decrease in serum cholesterol as a function of splenic parasite load.

Journal Article Ann Trop Med Parasitol · April 2011 Full text Link to item Cite

Analysis of multi-arm tumor growth trials in xenograft animals using phase change adaptive piecewise quadratic models.

Journal Article Stat Med · October 15, 2010 Featured Publication Xenograft trials allow tumor growth in human cell lines to be monitored over time in a mouse model. We consider the problem of inferring the effect of treatment combinations on tumor growth. A piecewise quadratic model with flexible phase change locations ... Full text Link to item Cite

Hypothesis testing for neural cell growth experiments using a hybrid branching process model.

Journal Article Biostatistics · October 2010 Featured Publication Neuron branching patterns can characterize neural cell types and act as markers for neurodegenerative disease and neural development. We develop a hybrid Markovian model for neural branching that extends previously published models by (i) using a discretiz ... Full text Link to item Cite

Analysis of spatial distribution of marker expression in cells using boundary distance plots

Journal Article Annals of Applied Statistics · September 1, 2010 Boundary distance (BD) plotting is a technique for making orientation invariant comparisons of the spatial distribution of biochemical markers within and across cells/nuclei. Marker expression is aggregated over points with the same distance from the bound ... Full text Cite

Population trends of widespread breeding birds in the Republic of Ireland 1998-2008

Journal Article Bird Study · August 1, 2010 Capsule The first analyses of trends in relative abundance of terrestrial birds in Ireland showed that trends were predominantly stable or increased between 1998 and 2008. Aims To determine trends in relative abundance of common and widespread breeding bir ... Full text Cite

Assessing operating characteristics of CAD algorithms in the absence of a gold standard.

Journal Article Med Phys · April 2010 Featured Publication PURPOSE: The authors examine potential bias when using a reference reader panel as "gold standard" for estimating operating characteristics of CAD algorithms for detecting lesions. As an alternative, the authors propose latent class analysis (LCA), which d ... Full text Link to item Cite

Computer-aided detection (CAD) of lung nodules in CT scans: radiologist performance and reading time with incremental CAD assistance.

Journal Article Eur Radiol · March 2010 OBJECTIVE: The diagnostic performance of radiologists using incremental CAD assistance for lung nodule detection on CT and their temporal variation in performance during CAD evaluation was assessed. METHODS: CAD was applied to 20 chest multidetector-row co ... Full text Link to item Cite

Regularized reconstruction of wave height and slope fields from refracted images of water

Journal Article Journal of the American Statistical Association · March 1, 2010 Refractive imaging of wave fields in an established experimental technique. We consider the associated reconstruction problem and investigate some statistically motivated refinements, including (a) bias correction of local slope estimates, (b) regularizati ... Full text Cite

A robust automated measure of average antibody staining in immunohistochemistry images.

Journal Article J Histochem Cytochem · February 2010 Featured Publication Identifying and scoring cancer markers plays a key role in oncology, helping to characterize the tumor and predict the clinical course of the disease. The current method for scoring immunohistochemistry (IHC) slides is labor intensive and has inherent issu ... Full text Link to item Cite

Analysis of the variability of a two-dimensional finite strain estimate

Journal Article Mathematical Geosciences · January 1, 2009 Finite strain estimation is a widely used technique for the study of rock deformation in structural geology. One particular algorithm proposed by Shimamoto and Ikeda uses the 'average shape matrix' of deformed markers. This paper provides a detailed error ... Full text Cite

A modular CDF approach for the approximation of percentiles

Journal Article Communications in Statistics: Simulation and Computation · November 1, 2008 This article describes a method for computing approximate statistics for large data sets, when exact computations may not be feasible. Such situations arise in applications such as climatology, data mining, and information retrieval (search engines). The k ... Full text Cite

Likelihood ratio tests for equality of shape under varying degrees of orientation invariance

Journal Article Journal of Multivariate Analysis · September 1, 2008 We consider a problem from image cytometry where the objective is to describe possible changes in the shape and orientation of cellular nuclei after treatment with a toxin. The shapes of nuclei are represented by individual ellipses. It is argued that the ... Full text Cite

Regularized reconstruction of water surfaces from noisy gradient information via plane-wave superposition

Journal Article Inverse Problems · June 1, 2008 Refraction-based imaging systems, used in wave tank facilities, provide measurements of local water surface gradients. The reconstruction of wave height fields from this information is considered. Utilizing the convenient approximation of target wave heigh ... Full text Cite

Morphometric analysis for early detection of changes in cellular structure in a toxicological experiment.

Journal Article Stat Med · December 20, 2007 Featured Publication This paper presents a method for semi-automatic analysis of morphometry in image cytometry studies. We examine morphological changes in neuroblastoma cells caused by a toxin. Nuclei are automatically recognized from images using a constrained seeded region ... Full text Link to item Cite

A statistical measure of regularity for the study of wind-generated wave field images

Journal Article Journal of the American Statistical Association · September 1, 2006 The study of water waves has generated a wealth of sophisticated modeling developments in applied mathematics. Empirical observation capabilities have created a need for novel data analysis tools. This article is motivated by consideration of wind-generate ... Full text Cite

A comparative error analysis of manual versus automated methods of data acquisition for algebraic strain estimation

Journal Article Tectonophysics · August 1, 2006 This paper presents a statistical analysis of the algebraic strain estimation algorithm of Shimamoto and Ikeda [Shimamoto, T., Ikeda, Y., 1976. A simple algebraic method for strain estimation from deformed eillipsoidal objects: 1. Basic theory. Tectonophys ... Full text Cite

Automated grain boundary detection by CASRG

Journal Article Journal of Structural Geology · March 1, 2006 Constrained automated seeded region growing (CASRG) is an algorithm for automated grain boundary detection. It uses as input a single digitised microphotograph, such as ones obtained from a polarising microscope with an attached digital camera. In addition ... Full text Cite

Farmer's lung is now in decline.

Journal Article Ir Med J · 2006 Farmer's lung incidence in Ireland was constant until 1996, even though hay making methods were revolutionised in late 1980's. We undertook this study to find out the incidence of farmer's lung in Ireland from 1982-2002 and its correlation with rainfall an ... Link to item Cite

SAPE: A program for semi-automatic parameter extraction for strain analysis

Journal Article Journal of Structural Geology · November 1, 2005 SAPE (Semi-Automatic Parameter Extraction) is a program for extracting information relevant to strain analysis from input digital images. Input images are manually produced by tracing the outlines of objects of interest. This is a less onerous, more object ... Full text Cite

Fitting an ellipse to an arbitrary shape: Implications for strain analysis

Journal Article Journal of Structural Geology · January 1, 2004 An ellipse can be fit to an arbitrary shape using a linear least squares approach applied to boundary data. Alternatively, this problem can also be solved by calculating the second moments of the entire region, a technique popular in image analysis applica ... Full text Cite

Sarcoma tumor FDG uptake measured by PET and patient outcome: a retrospective analysis.

Journal Article Eur J Nucl Med Mol Imaging · September 2002 Featured Publication In a retrospective analysis of patients with sarcoma who underwent fluorodeoxyglucose positron emission tomography (FDG PET) imaging, tumor maximum FDG uptake was analyzed for ability to predict patient survival and disease-free interval. Two hundred and n ... Full text Link to item Cite

An analysis of the role of positivity and mixture model constraints in poisson deconvolution problems

Journal Article Journal of Computational and Graphical Statistics · January 1, 2001 We consider a class of estimation problems in which data of a Poisson character are related by a linear model to a target function that satisfies certain physical constraints. The classic example of this situation is the reconstruction problem of positron ... Full text Cite

Natural fluctuations of hepatitis C viral load in a homogeneous patient population: a prospective study.

Journal Article Hepatology · January 2000 Featured Publication The aim of this study was to determine the variation in hepatitis C viral load over an extended period of patient follow up. Serum samples were collected from 49 female individuals who were identified as having been infected from the same source of hepatit ... Full text Link to item Cite

Constrained least squares regularization in PET

Journal Article IEEE Nuclear Science Symposium & Medical Imaging Conference · December 1, 1996 Standard reconstruction methods used in tomography produce images with undesirable negative artifacts in background and in areas of high local contrast. While sophisticated statistical reconstruction methods can be devised to correct for these artifacts, t ... Cite

Effect of foliar arrangement on the leaf epidermal structures in Areca palm (Areca catechu Linn.)

Journal Article Acta Botanica Neerlandica · January 1, 1996 The Areca palm (Areca catechu Linn.) shows alternate phyllotaxy with angular deflection of about 143°between two consecutive leaves, which leads to a spiral mechanism. Foliar spirality of the plant may either be left (FSL) or right (FSR). Analysis of data ... Full text Cite

Statistical examination of FBP and ML for estimating mixture models from dynamic PET data

Journal Article IEEE Nuclear Science Symposium & Medical Imaging Conference · December 1, 1995 We have been developing the use of mixture models for quantitative analysis of dynamic PET data (O'Sullivan, IEEE, TMI, 1993). In the approach pixel-wise time activity curve (TAC) data are represented as a mixture of a set of underlying sub-TACs correspond ... Cite