Scholars@Duke
Deborah Koltai

Deborah Koltai

Associate Professor in Psychiatry and Behavioral Sciences
Psychiatry & Behavioral Sciences, Adult Psychiatry & Psychology
attix001@duke.edu
Box 3333 Med Ctr, Durham, NC
Morreene Rd Clinic, Durham, NC
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Selected Publications

RECOVER-NEURO: study protocol for a multi-center, multi-arm, phase 2, randomized, active comparator trial evaluating three interventions for cognitive dysfunction in post-acute sequelae of SARS-CoV-2 infection (PASC).

Journal Article Trials · May 17, 2024 BACKGROUND: Post-acute sequelae of SARS-CoV-2 infection (PASC) symptoms have broad impact, and may affect individuals regardless of COVID-19 severity, socioeconomic status, race, ethnicity, or age. A prominent PASC symptom is cognitive dysfunction, colloqu ... Full text Open Access Link to item Cite

Depression following small vessel stroke is common and more prevalent in women.

Journal Article J Stroke Cerebrovasc Dis · May 2024 OBJECTIVES: We sought to examine the frequency of depression after small vessel-type stroke (SVS) and associated risk factors. MATERIALS AND METHODS: We conducted a retrospective analysis of a prospective cohort of patients enrolled in the American Stroke ... Full text Open Access Link to item Cite

Neuropsychological normative standards for late career physicians.

Journal Article Clin Neuropsychol · February 29, 2024 Objective: In the context of an aging, vital physician workforce, there is clear value in establishing a specialized neuropsychological normative dataset for the evaluation of late career physicians practicing clinical medicine. Methods: Physicians aged 60 ... Full text Link to item Cite

Epilepsy among the older population of sub-Saharan Africa: Analysis of the global burden of disease database.

Journal Article Epilepsy Behav · October 2023 INTRODUCTION: Epilepsy is considered one of the most burdensome neurologic diseases by the World Health Organization due to the high risk of morbidity and mortality. Few studies have investigated the epidemiology of idiopathic epilepsy in Sub-Saharan Afric ... Full text Link to item Cite

A prospective randomized study examining the impact of intravenous versus inhalational anesthesia on postoperative cognitive decline and delirium.

Journal Article Appl Neuropsychol Adult · August 12, 2023 The present prospective randomized study was designed to investigate whether the development of Post Operative Cognitive Decline (POCD) is related to anesthesia type in older adults. All patients were screened for delirium and mental status, received basel ... Full text Link to item Cite

"Walking the Journey Together": Creating a unique learning module in provider-patient communication for the care of epilepsy in Uganda.

Journal Article Epilepsy Behav · March 2023 OBJECTIVE: This report documents the creation of a practical communication skills module about epilepsy care, specifically targeted at first-line care providers who treat patients with epilepsy in Uganda. METHODS: Our team conducted semi-structured intervi ... Full text Link to item Cite

Evaluation of a tailored epilepsy training program for healthcare providers in Uganda.

Journal Article Epilepsy Behav · January 2023 OBJECTIVE: This study evaluated an epilepsy training program for healthcare workers that was designed to improve their knowledge of epilepsy, its treatment, and its psychosocial effects. METHODS: This single group, before and after survey was conducted in ... Full text Link to item Cite

Abstract P67: Role of Genetic Variants in Predicting Cognitive Outcomes Following Small Vessel Ischemic Stroke

Conference Stroke · March 2021 Background: About 20% of patients with small vessel ischemic stroke (SVS) have cognitive impairment; however, the role of genetic factors in predicting cognitive outcomes following SVS has not been fu ... Full text Cite

Sociocultural determinants and patterns of healthcare utilization for epilepsy care in Uganda.

Journal Article Epilepsy Behav · January 2021 OBJECTIVE: Epilepsy is a global public health concern, with the majority of cases occurring in lower- and middle-income countries where the treatment gap remains formidable. In this study, we simultaneously explore how beliefs about epilepsy causation, per ... Full text Link to item Cite

Epilepsy beliefs and misconceptions among patient and community samples in Uganda.

Journal Article Epilepsy Behav · January 2021 OBJECTIVE: The objective of the study was to characterize and compare the attitudes, beliefs, and perceptions about epilepsy across community and patient cohorts in Uganda. METHODS: This was a descriptive study utilizing two samples: a randomly selected, n ... Full text Link to item Cite

Healthcare provider perspectives regarding epilepsy care in Uganda.

Journal Article Epilepsy Behav · January 2021 OBJECTIVE: Epilepsy is the most common chronic neurological disorder in the world and imposes a large economic burden on global healthcare systems, especially in low-income settings and rural areas as is found in sub-Saharan Africa (SSA). Despite the high ... Full text Link to item Cite

Validity of the Personal Impact of Epilepsy Scale (PIES) in patients with epilepsy in Uganda.

Journal Article Epilepsy Behav · January 2021 PURPOSE: We sought to address the construct validity and reliability of the Personal Impact of Epilepsy Scale (PIES), an epilepsy-specific quality-of-life measure, in patients with epilepsy in Uganda. We also sought to assess the applicability of the scale ... Full text Link to item Cite

Stakeholder views of the practical and cultural barriers to epilepsy care in Uganda.

Journal Article Epilepsy Behav · January 2021 OBJECTIVE: Epilepsy is one of the most prevalent, treatable neurological diseases globally. In sub-Saharan Africa, people with epilepsy (PWE) frequently seek treatment from traditional or pastoral healers, who are more accessible than biomedical care provi ... Full text Link to item Cite

Pluralistic and singular causal attributions for epilepsy in Uganda.

Journal Article Epilepsy Behav · January 2021 OBJECTIVE: In Uganda, causal attributions for epilepsy reflect a variety of beliefs and impact care-seeking behavior, perpetuate stigma, and undermine the effectiveness of interventions to narrow the epilepsy treatment gap. The objective of this study was ... Full text Link to item Cite

Hospital-based epilepsy care in Uganda: A prospective study of three major public referral hospitals.

Journal Article Epilepsy Behav · January 2021 OBJECTIVE: This study sets out to describe the current demographics of people with epilepsy (PWE) attending hospital-based care in Uganda and the epilepsy treatment practices within three of the largest Ugandan public referral hospitals. METHODS: In a six- ... Full text Link to item Cite

Leveraging the lessons learned from studies on the cultural context of epilepsy care in Uganda: Opportunities and future directions.

Journal Article Epilepsy Behav · January 2021 In this summary paper, we review the body of research contained in this special issue, The Intersection of Culture, Resources, and Disease: Epilepsy Care in Uganda, and corollary recommendations for a way forward. We review key findings and conclusions for ... Full text Link to item Cite

Stigma reduction interventions for epilepsy: A systematized literature review.

Journal Article Epilepsy Behav · January 2021 OBJECTIVE: Epilepsy is a disease that is stigmatized globally. Several studies have introduced sensitization efforts to reduce stigma towards people with epilepsy (PWE) in various settings. Although sensitization efforts have shown some evidence of improve ... Full text Link to item Cite

Barriers to biomedical care for people with epilepsy in Uganda: A cross-sectional study.

Journal Article Epilepsy Behav · January 2021 OBJECTIVE: Epilepsy, a neurological disorder with effective biomedical treatment, remains largely untreated in Uganda. Potential reasons for this treatment gap (TG) include limited access to trained providers and clinics, social stigmata of seizures, cultu ... Full text Link to item Cite

Understanding the cultural context of epilepsy care in Uganda: Introduction to this special issue.

Journal Article Epilepsy Behav · January 2021 This article is part of the Special Issue "The Intersection of Culture, Resources, and Disease: Epilepsy Care in Uganda". ... Full text Link to item Cite

RECOVER-NEURO: study protocol for a multi-center, multi-arm, phase 2, randomized, active comparator trial evaluating three interventions for cognitive dysfunction in post-acute sequelae of SARS-CoV-2 infection (PASC).

Journal Article Trials · May 17, 2024 BACKGROUND: Post-acute sequelae of SARS-CoV-2 infection (PASC) symptoms have broad impact, and may affect individuals regardless of COVID-19 severity, socioeconomic status, race, ethnicity, or age. A prominent PASC symptom is cognitive dysfunction, colloqu ... Full text Open Access Link to item Cite

Depression following small vessel stroke is common and more prevalent in women.

Journal Article J Stroke Cerebrovasc Dis · May 2024 OBJECTIVES: We sought to examine the frequency of depression after small vessel-type stroke (SVS) and associated risk factors. MATERIALS AND METHODS: We conducted a retrospective analysis of a prospective cohort of patients enrolled in the American Stroke ... Full text Open Access Link to item Cite

Neuropsychological normative standards for late career physicians.

Journal Article Clin Neuropsychol · February 29, 2024 Objective: In the context of an aging, vital physician workforce, there is clear value in establishing a specialized neuropsychological normative dataset for the evaluation of late career physicians practicing clinical medicine. Methods: Physicians aged 60 ... Full text Link to item Cite

Epilepsy among the older population of sub-Saharan Africa: Analysis of the global burden of disease database.

Journal Article Epilepsy Behav · October 2023 INTRODUCTION: Epilepsy is considered one of the most burdensome neurologic diseases by the World Health Organization due to the high risk of morbidity and mortality. Few studies have investigated the epidemiology of idiopathic epilepsy in Sub-Saharan Afric ... Full text Link to item Cite

A prospective randomized study examining the impact of intravenous versus inhalational anesthesia on postoperative cognitive decline and delirium.

Journal Article Appl Neuropsychol Adult · August 12, 2023 The present prospective randomized study was designed to investigate whether the development of Post Operative Cognitive Decline (POCD) is related to anesthesia type in older adults. All patients were screened for delirium and mental status, received basel ... Full text Link to item Cite

"Walking the Journey Together": Creating a unique learning module in provider-patient communication for the care of epilepsy in Uganda.

Journal Article Epilepsy Behav · March 2023 OBJECTIVE: This report documents the creation of a practical communication skills module about epilepsy care, specifically targeted at first-line care providers who treat patients with epilepsy in Uganda. METHODS: Our team conducted semi-structured intervi ... Full text Link to item Cite

Evaluation of a tailored epilepsy training program for healthcare providers in Uganda.

Journal Article Epilepsy Behav · January 2023 OBJECTIVE: This study evaluated an epilepsy training program for healthcare workers that was designed to improve their knowledge of epilepsy, its treatment, and its psychosocial effects. METHODS: This single group, before and after survey was conducted in ... Full text Link to item Cite

Abstract P67: Role of Genetic Variants in Predicting Cognitive Outcomes Following Small Vessel Ischemic Stroke

Conference Stroke · March 2021 Background: About 20% of patients with small vessel ischemic stroke (SVS) have cognitive impairment; however, the role of genetic factors in predicting cognitive outcomes following SVS has not been fu ... Full text Cite

Sociocultural determinants and patterns of healthcare utilization for epilepsy care in Uganda.

Journal Article Epilepsy Behav · January 2021 OBJECTIVE: Epilepsy is a global public health concern, with the majority of cases occurring in lower- and middle-income countries where the treatment gap remains formidable. In this study, we simultaneously explore how beliefs about epilepsy causation, per ... Full text Link to item Cite

Epilepsy beliefs and misconceptions among patient and community samples in Uganda.

Journal Article Epilepsy Behav · January 2021 OBJECTIVE: The objective of the study was to characterize and compare the attitudes, beliefs, and perceptions about epilepsy across community and patient cohorts in Uganda. METHODS: This was a descriptive study utilizing two samples: a randomly selected, n ... Full text Link to item Cite

Healthcare provider perspectives regarding epilepsy care in Uganda.

Journal Article Epilepsy Behav · January 2021 OBJECTIVE: Epilepsy is the most common chronic neurological disorder in the world and imposes a large economic burden on global healthcare systems, especially in low-income settings and rural areas as is found in sub-Saharan Africa (SSA). Despite the high ... Full text Link to item Cite

Validity of the Personal Impact of Epilepsy Scale (PIES) in patients with epilepsy in Uganda.

Journal Article Epilepsy Behav · January 2021 PURPOSE: We sought to address the construct validity and reliability of the Personal Impact of Epilepsy Scale (PIES), an epilepsy-specific quality-of-life measure, in patients with epilepsy in Uganda. We also sought to assess the applicability of the scale ... Full text Link to item Cite

Stakeholder views of the practical and cultural barriers to epilepsy care in Uganda.

Journal Article Epilepsy Behav · January 2021 OBJECTIVE: Epilepsy is one of the most prevalent, treatable neurological diseases globally. In sub-Saharan Africa, people with epilepsy (PWE) frequently seek treatment from traditional or pastoral healers, who are more accessible than biomedical care provi ... Full text Link to item Cite

Pluralistic and singular causal attributions for epilepsy in Uganda.

Journal Article Epilepsy Behav · January 2021 OBJECTIVE: In Uganda, causal attributions for epilepsy reflect a variety of beliefs and impact care-seeking behavior, perpetuate stigma, and undermine the effectiveness of interventions to narrow the epilepsy treatment gap. The objective of this study was ... Full text Link to item Cite

Hospital-based epilepsy care in Uganda: A prospective study of three major public referral hospitals.

Journal Article Epilepsy Behav · January 2021 OBJECTIVE: This study sets out to describe the current demographics of people with epilepsy (PWE) attending hospital-based care in Uganda and the epilepsy treatment practices within three of the largest Ugandan public referral hospitals. METHODS: In a six- ... Full text Link to item Cite

Leveraging the lessons learned from studies on the cultural context of epilepsy care in Uganda: Opportunities and future directions.

Journal Article Epilepsy Behav · January 2021 In this summary paper, we review the body of research contained in this special issue, The Intersection of Culture, Resources, and Disease: Epilepsy Care in Uganda, and corollary recommendations for a way forward. We review key findings and conclusions for ... Full text Link to item Cite

Stigma reduction interventions for epilepsy: A systematized literature review.

Journal Article Epilepsy Behav · January 2021 OBJECTIVE: Epilepsy is a disease that is stigmatized globally. Several studies have introduced sensitization efforts to reduce stigma towards people with epilepsy (PWE) in various settings. Although sensitization efforts have shown some evidence of improve ... Full text Link to item Cite

Barriers to biomedical care for people with epilepsy in Uganda: A cross-sectional study.

Journal Article Epilepsy Behav · January 2021 OBJECTIVE: Epilepsy, a neurological disorder with effective biomedical treatment, remains largely untreated in Uganda. Potential reasons for this treatment gap (TG) include limited access to trained providers and clinics, social stigmata of seizures, cultu ... Full text Link to item Cite

Understanding the cultural context of epilepsy care in Uganda: Introduction to this special issue.

Journal Article Epilepsy Behav · January 2021 This article is part of the Special Issue "The Intersection of Culture, Resources, and Disease: Epilepsy Care in Uganda". ... Full text Link to item Cite

Vascular Cellular Adhesion Molecule-1 (VCAM-1) and Memory Impairment in African-Americans after Small Vessel-Type Stroke.

Journal Article J Stroke Cerebrovasc Dis · April 2020 BACKGROUND: African-Americans (AA) are 3 times more likely to have small-vessel-type ischemic strokes (SVS) than Whites. Small vessel strokes are associated with cognitive impairment, a relationship incompletely explained by white matter hyperintensity (WM ... Full text Link to item Cite

American Academy of Clinical Neuropsychology consensus conference statement on uniform labeling of performance test scores.

Journal Article Clin Neuropsychol · April 2020 Objectives: Descriptive labels of performance test scores are a critical component of communicating outcomes of neuropsychological and psychological evaluations. Yet, no universally accepted system exists for assigning qualitative descriptors to scores in ... Full text Link to item Cite

COVID-19-Associated Guillain-Barre Syndrome: Atypical Para-infectious Profile, Symptom Overlap, and Increased Risk of Severe Neurological Complications.

Journal Article SN Compr Clin Med · 2020 The concurrence of COVID-19 with Guillain-Barre syndrome (GBS) can increase the likelihood of neuromuscular respiratory failure, autonomic dysfunction, and other life-threatening symptoms. Currently, very little is known about the underlying mechanisms, cl ... Full text Open Access Link to item Cite

Pleiotropic Meta-Analysis of Cognition, Education, and Schizophrenia Differentiates Roles of Early Neurodevelopmental and Adult Synaptic Pathways.

Journal Article Am J Hum Genet · August 1, 2019 Susceptibility to schizophrenia is inversely correlated with general cognitive ability at both the phenotypic and the genetic level. Paradoxically, a modest but consistent positive genetic correlation has been reported between schizophrenia and educational ... Full text Link to item Cite

Author Correction: Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function.

Journal Article Nat Commun · May 1, 2019 Christina M. Lill, who contributed to analysis of data, was inadvertently omitted from the author list in the originally published version of this article. This has now been corrected in both the PDF and HTML versions of the article. ... Full text Link to item Cite

Multi-Trait Analysis of GWAS and Biological Insights Into Cognition: A Response to Hill (2018).

Journal Article Twin Res Hum Genet · October 2018 Hill (Twin Research and Human Genetics, Vol. 21, 2018, 84-88) presented a critique of our recently published paper in Cell Reports entitled 'Large-Scale Cognitive GWAS Meta-Analysis Reveals Tissue-Specific Neural Expression and Potential Nootropic Drug Tar ... Full text Link to item Cite

Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence.

Journal Article Nat Genet · July 2018 Intelligence is highly heritable1 and a major determinant of human health and well-being2. Recent genome-wide meta-analyses have identified 24 genomic loci linked to variation in intelligence3-7, but much about its genetic underpinnings remains to be disco ... Full text Link to item Cite

Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function.

Journal Article Nat Commun · May 29, 2018 General cognitive function is a prominent and relatively stable human trait that is associated with many important life outcomes. We combine cognitive and genetic data from the CHARGE and COGENT consortia, and UK Biobank (total N = 300,486; age 16-102) and ... Full text Link to item Cite

A Practical Guide to Geriatric Neuropsychology

Book · March 1, 2018 This book will be helpful for neuropsychologists interested in testing and providing recommendations for older adults and for psychologists interested in treating older adults. ... Cite

Large-Scale Cognitive GWAS Meta-Analysis Reveals Tissue-Specific Neural Expression and Potential Nootropic Drug Targets.

Journal Article Cell Rep · November 28, 2017 Here, we present a large (n = 107,207) genome-wide association study (GWAS) of general cognitive ability ("g"), further enhanced by combining results with a large-scale GWAS of educational attainment. We identified 70 independent genomic loci associated wi ... Full text Link to item Cite

GWAS meta-analysis reveals novel loci and genetic correlates for general cognitive function: a report from the COGENT consortium.

Journal Article Mol Psychiatry · November 2017 This corrects the article DOI: 10.1038/mp.2016.244. ... Full text Link to item Cite

Preventing Episodic Migraine With Caloric Vestibular Stimulation: A Randomized Controlled Trial.

Journal Article Headache · July 2017 OBJECTIVE: To evaluate the safety and efficacy of a novel solid-state, caloric vestibular stimulation (CVS) device to provide adjuvant therapy for the prevention of episodic migraine in adult migraineurs. BACKGROUND: Migraine causes significant disability ... Full text Link to item Cite

GWAS meta-analysis reveals novel loci and genetic correlates for general cognitive function: a report from the COGENT consortium.

Journal Article Mol Psychiatry · March 2017 The complex nature of human cognition has resulted in cognitive genomics lagging behind many other fields in terms of gene discovery using genome-wide association study (GWAS) methods. In an attempt to overcome these barriers, the current study utilized GW ... Full text Link to item Cite

Depressive Symptoms and Risk of Postoperative Delirium.

Journal Article Am J Geriatr Psychiatry · March 2016 OBJECTIVE: Previous studies have shown that elevated depressive symptoms are associated with increased risk of postoperative delirium. However, to our knowledge no previous studies have examined whether different components of depression are differentially ... Full text Link to item Cite

A comparison of the Cambridge Automated Neuropsychological Test Battery (CANTAB) with "traditional" neuropsychological testing instruments.

Journal Article J Clin Exp Neuropsychol · 2013 The Cambridge Neuropsychological Test Automated Battery (CANTAB) is frequently used in research protocols and increasingly in clinical practice. Despite the frequency of its use, important aspects of its measurement validity have yet to be established in h ... Full text Link to item Cite

A homopolymer polymorphism in the TOMM40 gene contributes to cognitive performance in aging.

Journal Article Alzheimers Dement · September 2012 INTRODUCTION: A highly polymorphic T homopolymer was recently found to be associated with late-onset Alzheimer's disease risk and age of onset. OBJECTIVE: To explore the effects of the polymorphic polyT tract (rs10524523, referred as '523') on cognitive pe ... Full text Link to item Cite

Neuropsychological evaluation

Chapter · March 28, 2012 Cite

Genetic and environmental correlates of topiramate-induced cognitive impairment.

Journal Article Epilepsia · January 2012 Topiramate is an antiepileptic drug that has marked treatment-limiting side effects on specific aspects of cognitive performance in both patients and healthy volunteers. Because these severe side effects occur only in certain individuals, identifying genet ... Full text Link to item Cite

Longitudinal Neuropsychological Outcomes of Postoperative Delirium

Conference CLINICAL NEUROPSYCHOLOGIST · January 1, 2012 Link to item Cite

Contribution of pastimes and testing strategies to the performance of healthy volunteers on cognitive tests.

Journal Article Clin Neuropsychol · July 2011 Clinicians routinely query factors known to impact cognitive test scores, including age and education. However, without data delineating the impact of less-frequently tracked variables, clinicians are limited to educated inferences about their effect. We e ... Full text Link to item Cite

Executive Functioning as a Predictor for Post-Operative Delirium

Conference CLINICAL NEUROPSYCHOLOGIST · January 1, 2011 Link to item Cite

Diversity Summit 2008: challenges in the recruitment and retention of ethnic minorities in neuropsychology.

Journal Article Clin Neuropsychol · November 2010 The 2008 Diversity Summit recognized the many advantages of increasing the number of neuropsychologists from ethnically diverse backgrounds. The Summit addressed the aspiration of creating a more ethnically diverse body of neuropsychologists by increasing ... Full text Link to item Cite

Official position of the American Academy of Clinical Neuropsychology on serial neuropsychological assessments: the utility and challenges of repeat test administrations in clinical and forensic contexts.

Journal Article Clin Neuropsychol · November 2010 Serial assessments are now common in neuropsychological practice, and have a recognized value in numerous clinical and forensic settings. These assessments can aid in differential diagnosis, tracking neuropsychological strengths and weaknesses over time, a ... Full text Link to item Cite

Differential patterns of cognitive decline in anterior and posterior white matter hyperintensity progression.

Journal Article Stroke · September 2010 BACKGROUND AND PURPOSE: White matter hyperintensities (WMHs) found on brain MRI in elderly individuals are largely thought to be due to microvascular disease, and its progression has been associated with cognitive decline. The present study sought to deter ... Full text Link to item Cite

Common genetic variation and performance on standardized cognitive tests.

Journal Article Eur J Hum Genet · July 2010 One surprising feature of the recently completed waves of genome-wide association studies is the limited impact of common genetic variation in individually detectable polymorphisms on many human traits. This has been particularly pronounced for studies on ... Full text Link to item Cite

Increasing awareness of clinical neuropsychology in the general public.

Journal Article Clin Neuropsychol · April 2010 We can only benefit from raising public awareness about the unique role of clinical neuropsychology in patient care and clinical research. Public awareness of the distinctive skills of our practitioners and researchers and the utility of our products may w ... Full text Link to item Cite

Models of developmental neuropsychology: Adult and geriatric

Chapter · January 1, 2010 Neuropsychologists often assess cognitive function to distinguish normal aging from pathological conditions. For elders, interpretation hinges on accurate conceptualization of cognitive performances associated with normal neurological aging versus deficits ... Full text Cite

A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB.

Journal Article Hum Mol Genet · December 1, 2009 Psychiatric disorders such as schizophrenia are commonly accompanied by cognitive impairments that are treatment resistant and crucial to functional outcome. There has been great interest in studying cognitive measures as endophenotypes for psychiatric dis ... Full text Link to item Cite

Surviving critical illness: acute respiratory distress syndrome as experienced by patients and their caregivers.

Journal Article Crit Care Med · October 2009 OBJECTIVE: To characterize the effects of critical illness in the daily lives and functioning of acute respiratory distress syndrome survivors. Survivors of acute respiratory distress syndrome, a systemic critical illness, often report poor quality of life ... Full text Link to item Cite

Executive function and depression as independent risk factors for postoperative delirium.

Journal Article Anesthesiology · April 2009 BACKGROUND: Postoperative delirium has been associated with greater complications, medical cost, and increased mortality during hospitalization. Recent evidence suggests that preoperative executive dysfunction and depression may predict postoperative delir ... Full text Link to item Cite

Measures of executive function and depression identify patients at risk for postoperative delirium.

Journal Article Anesthesiology · April 2009 BACKGROUND: Postoperative delirium is associated with increased morbidity and mortality. Preexisting cognitive impairment and depression have been frequently cited as important risk factors for this complication. This prospective cohort study was designed ... Full text Link to item Cite

The prediction of change: normative neuropsychological trajectories.

Journal Article Clin Neuropsychol · January 2009 While the application of normative standards is vital to the practice of clinical neuropsychology, data regarding normative change remains scarce despite the frequency of serial assessments. Based on 285 normal individuals, we provide co-normed baseline da ... Full text Link to item Cite

Neurocognitive correlates of response to treatment in late-life depression.

Journal Article Am J Geriatr Psychiatry · September 2008 UNLABELLED: Depression is often associated with neurocognitive deficits in older adults, particularly in the domains of information processing speed, episodic memory, and executive functions. Greater neurocognitive dysfunction while depressed is associated ... Full text Link to item Cite

Failure to replicate effect of Kibra on human memory in two large cohorts of European origin.

Journal Article Am J Med Genet B Neuropsychiatr Genet · July 5, 2008 It was recently suggested that the Kibra polymorphism rs17070145 has a strong effect on multiple episodic memory tasks in humans. We attempted to replicate this using two cohorts of European genetic origin (n = 319 and n = 365). We found no association wit ... Full text Link to item Cite

An efficient screening tool for preoperative depression: the Geriatric Depression Scale-Short Form.

Journal Article Anesth Analg · March 2008 BACKGROUND: Depression is highly prevalent in patients before surgery, and it has been widely shown to have a serious impact on their postoperative outcomes. It would therefore be desirable for physicians to obtain a quick, simple screen to evaluate depres ... Full text Link to item Cite

Cognitive risk factors for post-operative cognitive decline

Conference CLINICAL NEUROPSYCHOLOGIST · January 1, 2007 Link to item Cite

Human health effects of exposure to Pfiesteria piscicida: a review.

Journal Article Microbes Infect · June 2002 Since its identification, the dinoflagellate Pfiesteria piscicida has been implicated in fish kills and fish disease in the southeastern United States. Adverse health effects have been reported in researchers working with the organism and in watermen follo ... Full text Link to item Cite

Cohort studies of health effects among people exposed to estuarine waters: North Carolina, Virginia, and Maryland.

Journal Article Environ Health Perspect · October 2001 A variety of human symptoms have been associated with exposure to the dinoflagellate Pfiesteria and have been grouped together into a syndrome termed "possible estuary-associated syndrome." Prospective cohort studies of health effects associated with expos ... Full text Link to item Cite

Potential human health effects associated with laboratory exposures to Pfiesteria piscicida.

Journal Article Environ Health Perspect · October 2001 The adverse human health effects associated with the most prolonged and intense exposure known to Pfiesteria piscicida Steidinger & Burkholder cultures and toxin(s) are described. In December 1993, a patient presented with acute illness to the Memory Disor ... Full text Link to item Cite

Influence of anosognosia on treatment outcome among dementia patients

Journal Article Neuropsychological Rehabilitation · July 30, 2001 This study was a preliminary investigation of the effects of a Memory and Coping Program among mild to moderate dementia patients. A total of 24 elderly participants were randomly assigned to treatment and waiting-list control conditions. A pre-test, post- ... Full text Cite

Human visual function in the North Carolina clinical study on possible estuary-associated syndrome.

Journal Article J Toxicol Environ Health A · April 20, 2001 The U.S. Environmental Protection Agency assisted the North Carolina Department of Health and Human Services in conducting a study to investigate the potential for an association between fish kills in the North Carolina estuary system and the risk for pers ... Full text Link to item Cite

Estuary-associated syndrome in North Carolina: an occupational prevalence study.

Journal Article Environ Health Perspect · January 2001 Atlantic coast estuaries recently have experienced fish kills and fish with lesions attributed to Pfiesteria piscicida and related dinoflagellates. Human health effects have been reported from laboratory exposure and from a 1997 Maryland fish kill. North C ... Full text Link to item Cite

Subjective appraisals of memory functioning in dementia: Validity and cautions

Journal Article Archives of Clinical Neuropsychology · January 1, 1999 Full text Cite

The geriatric executive interview (EXIT): A measure of executive dysfunction or dementia?

Conference Archives of Clinical Neuropsychology · January 1, 1997 Full text Cite

The Rivermead behavioural memory test and Wechsler memory scale-revised: Relationship to everyday memory impairment

Journal Article Assessment · January 1, 1996 Investigations questioning the ecological validity of standardized neuropsychological instruments have led to the development of tests that are purported to be relevant to everyday functioning. The present investigation examined the relationships of the Ri ... Full text Cite