Scholars@Duke
Jeffrey Harold Lawson

Jeffrey Harold Lawson

Adjunct Professor in the Department of Surgery
Surgery, Vascular and Endovascular Surgery
lawso006@mc.duke.edu
Box 2622 Med Ctr, Durham, NC
481 Med Sci Res Bldg, Durham, NC
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Selected Publications

Evaluation of tissue-engineered human acellular vessels as a Blalock-Taussig-Thomas shunt in a juvenile primate model.

Journal Article JTCVS Open · September 2023 OBJECTIVES: Palliative treatment of cyanotic congenital heart disease (CCHD) uses systemic-to-pulmonary conduits, often a modified Blalock-Taussig-Thomas shunt (mBTTs). Expanded polytetrafluoroethylene (ePTFE) mBTTs have associated risks for thrombosis and ... Full text Link to item Cite

Six-year outcomes of a phase II study of human-tissue engineered blood vessels for peripheral arterial bypass.

Journal Article JVS Vasc Sci · 2023 OBJECTIVE: The human acellular vessel (HAV) was evaluated for surgical bypass in a phase II study. The primary results at 24 months after implantation have been reported, and the patients will be evaluated for ≤10 years. METHODS: In the present report, we ... Full text Link to item Cite

Patient-reported outcomes in hemodialysis vascular access: A call to action.

Journal Article J Vasc Access · November 2022 While access-related dysfunction is a clear driver of clinical outcomes and costs, the full impact of vascular access dysfunction on patient experience and quality of life is not fully characterized in the literature. One way to more comprehensively charac ... Full text Link to item Cite

Abstract P1017: Tissue Engineered Human Acellular Blood Vessels For Coronary Artery Bypass Grafting

Conference Circulation Research · August 5, 2022 Objective: Conduit for coronary artery bypass grafting (CABG) can be limited due to poor quality or prior removal of saphenous veins. A human acellular vessel (HAV) bioengineered from vascular cells a ... Full text Cite

Five Year Outcomes in Patients with End Stage Renal Disease Who Received a Bioengineered Human Acellular Vessel for Dialysis Access.

Journal Article EJVES Vasc Forum · 2022 OBJECTIVE: Patients with end stage renal failure who require haemodialysis suffer morbidity and mortality due to vascular access. Bioengineered human acellular vessels (HAVs) may provide a haemodialysis access option with fewer complications than other gra ... Full text Link to item Cite

Hemodialysis Reliable Outflow (HeRO) graft creation in upper extremities abandoned due to stent obstruction via recanalization and HeRO outflow component insertion across stent interstices.

Journal Article J Vasc Access · December 10, 2021 BACKGROUND: The purpose of this study was to assess the feasibility and outcomes of recanalization and subsequent HeRO graft outflow component insertion across stent interstices in patients with an otherwise abandoned upper extremity. METHODS: Over a 10-ye ... Full text Link to item Cite

Development of a Bioartificial Vascular Pancreas.

Journal Article J Tissue Eng · 2021 Transplantation of pancreatic islets has been shown to be effective, in some patients, for the long-term treatment of type 1 diabetes. However, transplantation of islets into either the portal vein or the subcutaneous space can be limited by insufficient o ... Full text Link to item Cite

Arterial reconstruction with human bioengineered acellular blood vessels in patients with peripheral arterial disease.

Journal Article J Vasc Surg · October 2020 OBJECTIVE: Vascular conduit is essential for arterial reconstruction for a number of conditions, including trauma and atherosclerotic occlusive disease. We have developed a tissue-engineered human acellular vessel (HAV) that can be manufactured, stored on ... Full text Link to item Cite

Challenges and novel therapies for vascular access in haemodialysis.

Journal Article Nat Rev Nephrol · October 2020 Advances in standards of care have extended the life expectancy of patients with kidney failure. However, options for chronic vascular access for haemodialysis - an essential part of kidney replacement therapy - have remained unchanged for decades. The hig ... Full text Link to item Cite

Bioengineered human blood vessels.

Journal Article Science (New York, N.Y.) · October 2020 Since the advent of the vascular anastomosis by Alexis Carrel in the early 20th century, the repair and replacement of blood vessels have been key to treating acute injuries, as well as chronic atherosclerotic disease. Arteries serve diverse mechanical and ... Full text Cite

Proteomic Analysis of Infants Undergoing Cardiopulmonary Bypass Using Contemporary Ontological Tools.

Journal Article J Surg Res · February 2020 BACKGROUND: Cardiopulmonary bypass (CPB) is essential for the repair of many congenital cardiac defects in infants but is associated with significant derangements in hemostasis and systemic inflammation. As a result, hemorrhagic complications and thrombosi ... Full text Link to item Cite

Treatment of Arm Swelling in Hemodialysis Patients with Ipsilateral Arteriovenous Access and Central Vein Stenosis: Conversion to the Hemodialysis Reliable Outflow Graft versus Stent Deployment.

Journal Article J Vasc Interv Radiol · February 2020 PURPOSE: To compare outcomes after conversion of arteriovenous (AV) access to Hemodialysis Reliable Outflow (HeRO) graft vs stent deployment in patients with arm swelling owing to ipsilateral central vein stenosis. MATERIALS AND METHODS: This single-center ... Full text Link to item Cite

Clinical implementation of the Humacyte human acellular vessel: Implications for military and civilian trauma care.

Journal Article J Trauma Acute Care Surg · July 2019 The incidence of wartime vascular injury has increased and is a leading cause of mortality and morbidity. While ligation remains an option, current resuscitation and damage control techniques have resulted in vascular repair being pursued in more than half ... Full text Link to item Cite

Bioengineered human acellular vessels recellularize and evolve into living blood vessels after human implantation.

Journal Article Sci Transl Med · March 27, 2019 Traditional vascular grafts constructed from synthetic polymers or cadaveric human or animal tissues support the clinical need for readily available blood vessels, but often come with associated risks. Histopathological evaluation of these materials has sh ... Full text Link to item Cite

Clinical Outcomes of Arteriovenous Access in Incident Hemodialysis Patients with Medicare Coverage, 2012-2014.

Journal Article Am J Nephrol · 2019 BACKGROUND: Chronic hemodialysis requires a mode of vascular access through an arteriovenous fistula (AVF), a prosthetic arteriovenous graft (AVG), or a central venous catheter (CVC). AVF is recommended over AVG or CVC due to increased patency and decrease ... Full text Link to item Cite

Erratum: Bioengineered human acellular vessels recellularize and evolve into living blood vessels after human implantation (Science Translational Medicine DOI: 10.1126/scitranslmed.aau6934)

Journal Article Science Translational Medicine · January 1, 2019 In the Research Article "Bioengineered human acellular vessels recellularize and evolve into living blood vessels after human implantation," the reference value for suture strength of HAVs was reported incorrectly within the Results section. The PDF and HT ... Full text Cite

Engineering Human Acellular Vessels for Dialysis Access and Vascular Repair

Conference Journal of the American College of Surgeons · October 2018 Full text Cite

Evaluation of tissue-engineered human acellular vessels as a Blalock-Taussig-Thomas shunt in a juvenile primate model.

Journal Article JTCVS Open · September 2023 OBJECTIVES: Palliative treatment of cyanotic congenital heart disease (CCHD) uses systemic-to-pulmonary conduits, often a modified Blalock-Taussig-Thomas shunt (mBTTs). Expanded polytetrafluoroethylene (ePTFE) mBTTs have associated risks for thrombosis and ... Full text Link to item Cite

Six-year outcomes of a phase II study of human-tissue engineered blood vessels for peripheral arterial bypass.

Journal Article JVS Vasc Sci · 2023 OBJECTIVE: The human acellular vessel (HAV) was evaluated for surgical bypass in a phase II study. The primary results at 24 months after implantation have been reported, and the patients will be evaluated for ≤10 years. METHODS: In the present report, we ... Full text Link to item Cite

Patient-reported outcomes in hemodialysis vascular access: A call to action.

Journal Article J Vasc Access · November 2022 While access-related dysfunction is a clear driver of clinical outcomes and costs, the full impact of vascular access dysfunction on patient experience and quality of life is not fully characterized in the literature. One way to more comprehensively charac ... Full text Link to item Cite

Abstract P1017: Tissue Engineered Human Acellular Blood Vessels For Coronary Artery Bypass Grafting

Conference Circulation Research · August 5, 2022 Objective: Conduit for coronary artery bypass grafting (CABG) can be limited due to poor quality or prior removal of saphenous veins. A human acellular vessel (HAV) bioengineered from vascular cells a ... Full text Cite

Five Year Outcomes in Patients with End Stage Renal Disease Who Received a Bioengineered Human Acellular Vessel for Dialysis Access.

Journal Article EJVES Vasc Forum · 2022 OBJECTIVE: Patients with end stage renal failure who require haemodialysis suffer morbidity and mortality due to vascular access. Bioengineered human acellular vessels (HAVs) may provide a haemodialysis access option with fewer complications than other gra ... Full text Link to item Cite

Hemodialysis Reliable Outflow (HeRO) graft creation in upper extremities abandoned due to stent obstruction via recanalization and HeRO outflow component insertion across stent interstices.

Journal Article J Vasc Access · December 10, 2021 BACKGROUND: The purpose of this study was to assess the feasibility and outcomes of recanalization and subsequent HeRO graft outflow component insertion across stent interstices in patients with an otherwise abandoned upper extremity. METHODS: Over a 10-ye ... Full text Link to item Cite

Development of a Bioartificial Vascular Pancreas.

Journal Article J Tissue Eng · 2021 Transplantation of pancreatic islets has been shown to be effective, in some patients, for the long-term treatment of type 1 diabetes. However, transplantation of islets into either the portal vein or the subcutaneous space can be limited by insufficient o ... Full text Link to item Cite

Arterial reconstruction with human bioengineered acellular blood vessels in patients with peripheral arterial disease.

Journal Article J Vasc Surg · October 2020 OBJECTIVE: Vascular conduit is essential for arterial reconstruction for a number of conditions, including trauma and atherosclerotic occlusive disease. We have developed a tissue-engineered human acellular vessel (HAV) that can be manufactured, stored on ... Full text Link to item Cite

Challenges and novel therapies for vascular access in haemodialysis.

Journal Article Nat Rev Nephrol · October 2020 Advances in standards of care have extended the life expectancy of patients with kidney failure. However, options for chronic vascular access for haemodialysis - an essential part of kidney replacement therapy - have remained unchanged for decades. The hig ... Full text Link to item Cite

Bioengineered human blood vessels.

Journal Article Science (New York, N.Y.) · October 2020 Since the advent of the vascular anastomosis by Alexis Carrel in the early 20th century, the repair and replacement of blood vessels have been key to treating acute injuries, as well as chronic atherosclerotic disease. Arteries serve diverse mechanical and ... Full text Cite

Proteomic Analysis of Infants Undergoing Cardiopulmonary Bypass Using Contemporary Ontological Tools.

Journal Article J Surg Res · February 2020 BACKGROUND: Cardiopulmonary bypass (CPB) is essential for the repair of many congenital cardiac defects in infants but is associated with significant derangements in hemostasis and systemic inflammation. As a result, hemorrhagic complications and thrombosi ... Full text Link to item Cite

Treatment of Arm Swelling in Hemodialysis Patients with Ipsilateral Arteriovenous Access and Central Vein Stenosis: Conversion to the Hemodialysis Reliable Outflow Graft versus Stent Deployment.

Journal Article J Vasc Interv Radiol · February 2020 PURPOSE: To compare outcomes after conversion of arteriovenous (AV) access to Hemodialysis Reliable Outflow (HeRO) graft vs stent deployment in patients with arm swelling owing to ipsilateral central vein stenosis. MATERIALS AND METHODS: This single-center ... Full text Link to item Cite

Clinical implementation of the Humacyte human acellular vessel: Implications for military and civilian trauma care.

Journal Article J Trauma Acute Care Surg · July 2019 The incidence of wartime vascular injury has increased and is a leading cause of mortality and morbidity. While ligation remains an option, current resuscitation and damage control techniques have resulted in vascular repair being pursued in more than half ... Full text Link to item Cite

Bioengineered human acellular vessels recellularize and evolve into living blood vessels after human implantation.

Journal Article Sci Transl Med · March 27, 2019 Traditional vascular grafts constructed from synthetic polymers or cadaveric human or animal tissues support the clinical need for readily available blood vessels, but often come with associated risks. Histopathological evaluation of these materials has sh ... Full text Link to item Cite

Clinical Outcomes of Arteriovenous Access in Incident Hemodialysis Patients with Medicare Coverage, 2012-2014.

Journal Article Am J Nephrol · 2019 BACKGROUND: Chronic hemodialysis requires a mode of vascular access through an arteriovenous fistula (AVF), a prosthetic arteriovenous graft (AVG), or a central venous catheter (CVC). AVF is recommended over AVG or CVC due to increased patency and decrease ... Full text Link to item Cite

Erratum: Bioengineered human acellular vessels recellularize and evolve into living blood vessels after human implantation (Science Translational Medicine DOI: 10.1126/scitranslmed.aau6934)

Journal Article Science Translational Medicine · January 1, 2019 In the Research Article "Bioengineered human acellular vessels recellularize and evolve into living blood vessels after human implantation," the reference value for suture strength of HAVs was reported incorrectly within the Results section. The PDF and HT ... Full text Cite

Engineering Human Acellular Vessels for Dialysis Access and Vascular Repair

Conference Journal of the American College of Surgeons · October 2018 Full text Cite

Drug Coated Balloon Angioplasty in Failing AV Fistulas: A Randomized Controlled Trial.

Journal Article Clin J Am Soc Nephrol · August 7, 2018 BACKGROUND: Restenosis remains a problem in hemodialysis access interventions. Paclitaxel-coated balloons have shown promise in reducing access-related restenosis in small trials. The primary hypotheses for our multicenter trial were superior effectiveness ... Full text Link to item Cite

Definitions and End Points for Interventional Studies for Arteriovenous Dialysis Access.

Journal Article Clin J Am Soc Nephrol · March 7, 2018 This paper is part of the Clinical Trial Endpoints for Dialysis Vascular Access Project of the American Society of Nephrology Kidney Health Initiative. The purpose of this project is to promote research in vascular access by clarifying trial end points whi ... Full text Link to item Cite

Susceptibility of ePTFE vascular grafts and bioengineered human acellular vessels to infection.

Journal Article J Surg Res · January 2018 BACKGROUND: Synthetic expanded polytetrafluorethylene (ePTFE) grafts are routinely used for vascular repair and reconstruction but prone to sustained bacterial infections. Investigational bioengineered human acellular vessels (HAVs) have shown clinical suc ... Full text Link to item Cite

Interleukin-9 mediates chronic kidney disease-dependent vein graft disease: a role for mast cells.

Journal Article Cardiovasc Res · November 1, 2017 AIMS: Chronic kidney disease (CKD) is a powerful independent risk factor for cardiovascular events, including vein graft failure. Because CKD impairs the clearance of small proteins, we tested the hypothesis that CKD exacerbates vein graft disease by eleva ... Full text Open Access Link to item Cite

Arteriovenous Fistulae for Haemodialysis: A Systematic Review and Meta-analysis of Efficacy and Safety Outcomes.

Journal Article Eur J Vasc Endovasc Surg · October 2017 BACKGROUND: Arteriovenous fistulae are the currently recommended gold standard vascular access modality for haemodialysis because of their prolonged patency, improved durability, and low risk of infection for those that mature. However, notable disadvantag ... Full text Link to item Cite

Bioengineered Human Acellular Vessels for Dialysis Access: Completed Phase 2 Studies

Conference Journal of the American College of Surgeons · October 2017 Full text Cite

The impact of femoral arterial thrombosis in paediatric cardiac catheterisation: a national study.

Journal Article Cardiol Young · July 2017 BACKGROUND: Previous studies have identified risk factors for femoral arterial thrombosis after paediatric cardiac catheterisation, but none of them have evaluated the clinical and economic significance of this complication at the population level. Therefo ... Full text Link to item Cite

Establishing patient-specific criteria for selecting the optimal upper extremity vascular access procedure.

Journal Article J Vasc Surg · April 2017 OBJECTIVE: The Kidney Disease Outcome Quality Initiative and Fistula First Breakthrough Initiative call for the indiscriminate creation of arteriovenous fistulas (AVFs) over arteriovenous grafts (AVGs) without providing patient-specific criteria for vascul ... Full text Link to item Cite

Bioengineered hemodialysis access grafts.

Journal Article J Vasc Access · March 6, 2017 There is a need for bioengineered therapies to improve the overall health of the growing and aging world population. Patients with renal failure have a life-long requirement for a durable form of hemodialysis vascular access. In this article, we review the ... Full text Link to item Cite

Forearm versus upper arm grafts for vascular access.

Journal Article J Vasc Access · March 6, 2017 Forearm and upper arm arteriovenous grafts perform similarly in terms of patency and complications. Primary patency at 1 year for forearm arteriovenous grafts versus upper arm grafts ranges from 22%-50% versus 22%-42%, and secondary patency at 1 year range ... Full text Link to item Cite

Meta-analysis of individual-patient data from EVAR-1, DREAM, OVER and ACE trials comparing outcomes of endovascular or open repair for abdominal aortic aneurysm over 5 years.

Journal Article Br J Surg · February 2017 BACKGROUND: The erosion of the early mortality advantage of elective endovascular aneurysm repair (EVAR) compared with open repair of abdominal aortic aneurysm remains without a satisfactory explanation. METHODS: An individual-patient data meta-analysis of ... Full text Link to item Cite

Operative and perioperative management of infected arteriovenous grafts.

Journal Article J Vasc Access · January 18, 2017 Vascular graft infections are a particularly troublesome complication for dialysis patients, many of whom are in an already immunocompromised state. The objective of this review is to detail the risk factors, etiology, diagnosis, perioperative and operativ ... Full text Link to item Cite

Early infection risk with primary versus staged Hemodialysis Reliable Outflow (HeRO) graft implantation.

Journal Article J Vasc Surg · January 2017 OBJECTIVE: This study evaluated whether the use of a staged Hemodialysis Reliable Outflow (HeRO; Merit Medical, South Jordan, Utah) implantation strategy incurs increased early infection risk compared with conventional primary HeRO implantation. METHODS: A ... Full text Link to item Cite

Bioengineered human acellular vessels for dialysis access in patients with end-stage renal disease: two phase 2 single-arm trials.

Journal Article Lancet · May 14, 2016 BACKGROUND: For patients with end-stage renal disease who are not candidates for fistula, dialysis access grafts are the best option for chronic haemodialysis. However, polytetrafluoroethylene arteriovenous grafts are prone to thrombosis, infection, and in ... Full text Link to item Cite

Tissue engineered vascular grafts: Origins, development, and current strategies for clinical application.

Journal Article Methods · April 15, 2016 Since the development of a dependable and durable synthetic non-autogenous vascular conduit in the mid-twentieth century, the field of vascular surgery has experienced tremendous growth. Concomitant with this growth, development in the field of bioengineer ... Full text Link to item Cite

The effect of location and configuration on forearm and upper arm hemodialysis arteriovenous grafts.

Conference J Vasc Surg · November 2015 OBJECTIVE: The arteriovenous graft (AVG) is most often used in hemodialysis patients when an autogenous fistula is not feasible. The optimal location (forearm or upper arm) and configuration (loop or straight) of AVGs are not known. To evaluate relationshi ... Full text Link to item Cite

Jeffrey Lawson, MD, Describes Development of a Bioengineered Blood Vessel

Journal Article Vascular Disease Management · March 1, 2015 Cite

Hemodialysis Reliable Outflow device impingement in the subclavian position: a case report.

Journal Article J Vasc Access · 2015 PURPOSE: The purpose of this study is to report a case of Hemodialysis Reliable Outflow (HeRO) device malfunction in the subclavian position secondary to costoclavicular impingement. METHODS AND RESULTS: The electronic medical record was reviewed for the p ... Full text Link to item Cite

Paradoxical embolus following percutaneous thrombectomy of hemodialysis reliable outflow graft.

Journal Article J Vasc Access · 2015 Percutaneous interventions to maintain or re-establish patent vascular access are common and often necessary for patients on hemodialysis. This case illustrates an extremely rare but potentially devastating complication of one of these procedures: cerebrov ... Full text Link to item Cite

Atypical aortic thrombus: should nonoperative management be first line?

Journal Article Ann Vasc Surg · October 2014 BACKGROUND: Aortic thrombus in the absence of atherosclerotic plaque or aneurysm is rare, and its optimal management remains unclear. Although atypical aortic thrombus (AAT) has been historically managed operatively, successful nonoperative strategies have ... Full text Link to item Cite

Management of anticoagulation agents in trauma patients.

Journal Article Clin Lab Med · September 2014 A lack of consensus on anticoagulant reversal during acute trauma is compounded by an aging population and the expanding spectrum of new anticoagulation agents. Developments in laboratory assays and transfusion medicine, including thromboelastography, reco ... Full text Link to item Cite

A comparison between the HeRO graft and conventional arteriovenous grafts in hemodialysis patients.

Journal Article Semin Dial · 2014 Venous stenosis and occlusion are a major cause of vascular access dysfunction and failure. The HeRO Graft bypasses occlusion and traverses stenosis with outflow directly into the central venous circulation. A randomized, multicenter study was conducted to ... Full text Link to item Cite

Percutaneous interventions on the hemodialysis reliable outflow vascular access device.

Journal Article J Vasc Interv Radiol · April 2013 PURPOSE: To determine the outcomes of percutaneous interventions for prolonging the patency of the Hemodialysis Reliable Outflow (HeRO) device. MATERIALS AND METHODS: Between January 2007 and August 2011, 73 percutaneous interventions were performed on 26 ... Full text Link to item Cite

A multi-center, dose-escalation study of human type I pancreatic elastase (PRT-201) administered after arteriovenous fistula creation.

Journal Article J Vasc Access · 2013 PURPOSE: To explore the safety and efficacy of PRT-201. METHODS: Randomized, double-blind, placebo-controlled, single-dose escalation study of PRT-201 (0.0033 to 9 mg) applied after arteriovenous fistula (AVF) creation. Participants were followed for one y ... Full text Link to item Cite

Tissue-engineered vascular grafts: autologous off-the-shelf vascular access?

Journal Article Semin Nephrol · November 2012 Dialysis grafts have provided reliable access for millions of patients in need of renal replacement therapy. However, regardless of the material used for artificial dialysis grafts their mean patency remains generally poor and infection rates are greater t ... Full text Link to item Cite

Assessment of vascular contrast and depiction of stenoses in abdominopelvic and lower extremity vasculature: comparison of dual-energy MDCT with digital subtraction angiography.

Journal Article Acad Radiol · September 2012 RATIONALE AND OBJECTIVES: To assess whether dual-energy computed tomography (DECT) multidetector computed tomography (MDCT) angiography improves vascular contrast beyond MDCT angiography and digital subtraction angiography (DSA) while preserving the abilit ... Full text Link to item Cite

Multi-center experience of 164 consecutive Hemodialysis Reliable Outflow [HeRO] graft implants for hemodialysis treatment.

Journal Article Eur J Vasc Endovasc Surg · July 2012 OBJECTIVE: To report a multi-center experience with the novel Hemodialysis Reliable Outflow (HeRO) vascular access graft. MATERIALS AND METHODS: Four centers conducted a retrospective review of end stage renal disease patients who received the HeRO device ... Full text Link to item Cite

Analysis of infection risk following covered stent exclusion of pseudoaneurysms in prosthetic arteriovenous hemodialysis access grafts.

Journal Article J Vasc Interv Radiol · January 2012 PURPOSE: To determine whether exclusion of pseudoaneurysms with the use of a covered stent in prosthetic arteriovenous (AV) hemodialysis access grafts impacts the incidence of eventual AV graft infection. MATERIALS AND METHODS: Review of an interventional ... Full text Link to item Cite

Use of autologous blood-derived endothelial progenitor cells at point-of-care to protect against implant thrombosis in a large animal model.

Journal Article Biomaterials · November 2011 Titanium (Ti) is commonly utilized in many cardiovascular devices, e.g. as a component of Nitinol stents, intra- and extracorporeal mechanical circulatory assist devices, but is associated with the risk of thromboemboli formation. We propose to solve this ... Full text Link to item Cite

Influence of diabetes and perivascular allogeneic endothelial cell implants on arteriovenous fistula remodeling.

Journal Article J Vasc Surg · November 2011 OBJECTIVES: Arteriovenous fistula (AVF) is the preferred type of vascular access for hemodialysis to treat end-stage renal disease. A high proportion of AVF are never used for dialysis because the vein fails to mature adequately. We have previously describ ... Full text Link to item Cite

An early study on the mechanisms that allow tissue-engineered vascular grafts to resist intimal hyperplasia.

Journal Article J Cardiovasc Transl Res · October 2011 Intimal hyperplasia is one of the prominent failure mechanisms for arteriovenous fistulas and arteriovenous access grafts. Human tissue-engineered vascular grafts (TEVGs) were implanted as arteriovenous grafts in a novel baboon model. Ultrasound was used t ... Full text Link to item Cite

In vitro functional testing of endothelial progenitor cells that overexpress thrombomodulin.

Journal Article Tissue Eng Part A · August 2011 This study investigated the augmentation of endothelial progenitor cell (EPC) thromboresistance by using gene therapy to overexpress thrombomodulin (TM), an endothelial cell membrane glycoprotein that has potent anti-coagulant properties. Late outgrowth EP ... Full text Link to item Cite

Autologous bone marrow mononuclear cell therapy is safe and promotes amputation-free survival in patients with critical limb ischemia.

Journal Article J Vasc Surg · June 2011 OBJECTIVE: The purpose of this Phase I open label nonrandomized trial was to assess the safety and efficacy of autologous bone marrow mononuclear cell (ABMNC) therapy in promoting amputation-free survival (AFS) in patients with critical limb ischemia (CLI) ... Full text Link to item Cite

Decellularized tissue-engineered blood vessel as an arterial conduit.

Journal Article Proc Natl Acad Sci U S A · May 31, 2011 Arterial tissue-engineering techniques that have been reported previously typically involve long waiting times of several months while cells from the recipient are cultured to create the engineered vessel. In this study, we developed a different approach t ... Full text Link to item Cite

Use of aspirin associates with longer primary patency of hemodialysis grafts.

Journal Article J Am Soc Nephrol · April 2011 Extended-release dipyridamole plus low-dose aspirin (ERDP/ASA) prolongs primary unassisted graft patency of newly created hemodialysis arteriovenous grafts, but the individual contributions of each component are unknown. Here, we analyzed whether use of as ... Full text Link to item Cite

Salvaging vascular access and treatment of severe limb edema: case reports on the novel use of the hemodialysis reliable outflow vascular access device.

Journal Article Ann Vasc Surg · April 2011 We report two cases in which patients on chronic hemodialysis presented with morbid unilateral edema of the upper extremity and chest on the side of a currently functioning arteriovenous access. Both patients were known to the vascular surgery service and ... Full text Link to item Cite

Readily available tissue-engineered vascular grafts.

Journal Article Sci Transl Med · February 2, 2011 Autologous or synthetic vascular grafts are used routinely for providing access in hemodialysis or for arterial bypass in patients with cardiovascular disease. However, some patients either lack suitable autologous tissue or cannot receive synthetic grafts ... Full text Link to item Cite

The biocompatibility of titanium cardiovascular devices seeded with autologous blood-derived endothelial progenitor cells: EPC-seeded antithrombotic Ti implants.

Journal Article Biomaterials · January 2011 Implantable and extracorporeal cardiovascular devices are commonly made from titanium (Ti) (e.g. Ti-coated Nitinol stents and mechanical circulatory assist devices). Endothelializing the blood-contacting Ti surfaces of these devices would provide them with ... Full text Link to item Cite

Introduction

Journal Article Literature and Theology: New Interdisciplinary Spaces · January 1, 2011 Full text Cite

A comprehensive review of topical hemostatic agents: efficacy and recommendations for use.

Journal Article Ann Surg · February 2010 Since ancient times we have attempted to facilitate hemostasis by application of topical agents. In the last decade, the number of different effective hemostatic agents has increased drastically. In order for the modern surgeon to successfully choose the r ... Full text Link to item Cite

Multidisciplinary approach to the challenge of hemostasis.

Other Anesth Analg · February 1, 2010 A multidisciplinary panel consisting of experts chosen by the 2 chairs of the group representing experts in anesthesiology, blood banking, hematology, critical care medicine, and various surgical disciplines (trauma, cardiac, pediatric, neurologic, obstetr ... Full text Link to item Cite

Surgical aspects and biological considerations of arteriovenous fistula placement.

Journal Article Semin Dial · 2010 Since the Fistula First Initiative was formulated in 2003, providers and payers have increasingly emphasized the need to create more arteriovenous fistulae. To maximize the chances of successful fistula maturation, a thorough understanding of the biology a ... Full text Link to item Cite

Regenerating titanium ventricular assist device surfaces after gold/palladium coating for scanning electron microscopy.

Journal Article Microsc Res Tech · January 2010 Titanium is one of the most commonly used materials for implantable devices in humans. Scanning electron microscopy (SEM) serves as an important tool for imaging titanium surfaces and analyzing cells and other organic matter adhering to titanium implants. ... Full text Link to item Cite

Application of energy-based technologies and topical hemostatic agents in the management of surgical hemostasis.

Journal Article Vascular · 2010 Achieving intraoperative hemostasis is essential for excellent surgical outcomes. A variety of methods, ranging from mechanical tools and energy-based technologies to topical hemostatic agents, are available to the modern surgeon. Given that bleeding devel ... Full text Link to item Cite

Multicenter phase I/II trial of the safety of allogeneic endothelial cell implants after the creation of arteriovenous access for hemodialysis use: the V-HEALTH study.

Journal Article J Vasc Surg · December 2009 OBJECTIVES: Vascular access dysfunction is the major cause of morbidity in patients on hemodialysis to treat end stage renal disease. Preclinical studies have demonstrated that the perivascular placement of implants containing allogeneic aortic endothelial ... Full text Link to item Cite

Initial experience and outcome of a new hemodialysis access device for catheter-dependent patients.

Journal Article J Vasc Surg · September 2009 OBJECTIVE: The effects of a new long-term subcutaneous vascular access device were studied in access-challenged patients who were poor candidates for fistulas or grafts due to venous obstruction. Bacteremia rates, patency, and function of the Hemodialysis ... Full text Link to item Cite

Acute in-vivo evaluation of bleeding with Gelfoam plus saline and Gelfoam plus human thrombin using a liver square lesion model in swine.

Journal Article J Thromb Thrombolysis · July 2009 BACKGROUND: Management of post-operative bleeding has historically used topical bovine thrombin. However, possible harm through activation of coagulation inhibitors has encouraged investigation with other hemostatic agents. This study utilized a novel ordi ... Full text Link to item Cite

Anticoagulation strategies for venous thromboembolism.

Journal Article Perspect Vasc Surg Endovasc Ther · June 2009 Venous thromboembolism (VTE) continues to be a major source of morbidity and mortality in the United States with an estimated incidence of greater than 600 000 clinically evident cases each year. It results in more than 200 000 deaths per year and is thoug ... Full text Link to item Cite

Effect of dipyridamole plus aspirin on hemodialysis graft patency.

Journal Article N Engl J Med · May 21, 2009 BACKGROUND: Arteriovenous graft stenosis leading to thrombosis is a major cause of complications in patients undergoing hemodialysis. Procedural interventions may restore patency but are costly. Although there is no proven pharmacologic therapy, dipyridamo ... Full text Link to item Cite

Right ventricular hypertrophy with early dysfunction: A proteomics study in a neonatal model.

Journal Article J Thorac Cardiovasc Surg · May 2009 OBJECTIVE: Right ventricular hypertrophy and subsequent dysfunction is common in patients with congenital heart defects, but the molecular mechanisms underlying change from adaptive hypertrophy to dysfunction remain elusive. We used the novel technique of ... Full text Link to item Cite

Surgical excision of infected arteriovenous grafts: technique and review.

Journal Article J Vasc Access · 2009 Infected prosthetic arteriovenous grafts for hemodialysis present a profound risk to patient well being. Here we present five recent cases and describe our technique for total graft excision. We also review the literature and discuss the much debated role ... Full text Link to item Cite

Congenital jugular vein phlebectasia: a case report and review of the literature.

Journal Article Ann Vasc Surg · September 2008 Fusiform dilation of the jugular vein, or jugular venous phlebectasia, is a rare clinical entity, with an etiology of cervical swelling. We present a case of a 15-year-old male with no antecedent history of trauma and an enlarging right neck mass. Pertinen ... Full text Link to item Cite

Genomic modeling of atherosclerosis in peripheral arterial disease and its variant phenotype in patients with diabetes.

Journal Article Vascular · 2008 Microarrays can be used to discover candidate genes associated with peripheral arterial disease (PAD) and develop models that predict patient clinical status. We hypothesize that multiple phenotypes of PAD with distinct patterns of gene expression exist. W ... Full text Link to item Cite

Management of surgical hemostasis: topical agents.

Journal Article Vascular · 2008 Intraoperative control of bleeding during any surgical procedure is vital for achieving a positive patient outcome. Hemostasis can be achieved through practical and effective systemic or topical approaches. A variety of hemostatic methods can be employed, ... Link to item Cite

Review of the biology of bleeding and clotting in the surgical patient.

Journal Article Vascular · 2008 To effectively balance bleeding and clotting in surgical patients, the surgeon needs a fundamental knowledge of coagulation biology. The endothelium and activated platelets play crucial roles in coagulation. Activated platelets and damaged endothelial cell ... Link to item Cite

Effectiveness of Glycerol Mono-oleate as a Biosealant.

Journal Article J Invasive Cardiol · January 2008 BACKGROUND: The number of femoral artery catheterizations will increase over the next decade to more than 9 million worldwide. Accordingly, a new era of access site management with vascular closure techniques utilizing biologics are being developed and imp ... Link to item Cite

Bovine thrombin: history, use, and risk in the surgical patient.

Journal Article Vascular · 2008 Thrombin is a common hemostatic drug used in surgical practice for over 100 years because of its simplicity and efficacy. Thrombin converts fibrinogen to fibrin, activates platelets, and induces vascular contraction. It is available in multiple forms, incl ... Link to item Cite

Management of hemostasis in vascular surgery.

Journal Article Surgery · October 2007 The fate of the circulatory system in response to vascular injury is governed by a series of complex biochemical reactions involving cellular elements and plasma proteins. Alteration of this hemostatic balance can result in excessive bleeding or procoagula ... Full text Link to item Cite

Adventitial endothelial implants reduce matrix metalloproteinase-2 expression and increase luminal diameter in porcine arteriovenous grafts.

Journal Article J Vasc Surg · September 2007 OBJECTIVE: Vascular access dysfunction is a major problem in hemodialysis patients. Only 50% of arteriovenous grafts (AVGs) will remain patent 1 year after surgery. AVGs frequently develop stenoses and occlusions at the venous anastomoses in the venous out ... Full text Link to item Cite

An amphiphilic lipid compound is an effective biosealant agent and bacterial deterrent

Conference ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY · June 1, 2007 Link to item Cite

The balance of thrombosis and hemorrhage in surgery.

Journal Article Hematol Oncol Clin North Am · February 2007 Postoperative hemorrhage and thrombosis is a significant problem during the perioperative period. Understanding the complex and dynamic interplay of factors, proteins, and enzymes during coagulation is imperative to maintain balance between hemostasis and ... Full text Link to item Cite

Regulation of hemostatic system function by biochemical and mechanical factors

Chapter · January 1, 2007 The mammalian hemostatic system has evolved to accomplish the task of sealing defects in the cardiovascular system. Hemostasis occurs in and around a disruption in a vascular conduit through which blood normally flows, and is characterized by the localized ... Full text Cite

Hypercoagulable states associated with chronic venous insufficiency

Journal Article · January 1, 2007 This chapter discusses the hypercoagulable states associated with chronoic venous insufficiency. For many patients with deep venous thrombosis (DVT), the clinical course following an initial thrombotic event may be complicated by further manifestations of ... Full text Cite

The scientific basis for evaluation and management of thrombotic disorders.

Journal Article Thorac Surg Clin · November 2006 The hemostatic mechanisms at work in the body involve a complex series of interactions between platelets, the endothelium, and the coagulation cascade. Much has been learned regarding the molecular mechanisms governing these intricate processes. The hyperc ... Full text Link to item Cite

Proteomics of cerebral injury in a neonatal model of cardiopulmonary bypass with deep hypothermic circulatory arrest.

Journal Article J Thorac Cardiovasc Surg · October 2006 OBJECTIVE: Concern over neurologic injury limits safe duration of deep hypothermic circulatory arrest (DHCA) in surgery for congenital cardiac disease. Proteomics is a novel and powerful technique to study global protein changes in a given protein system. ... Full text Link to item Cite

Stem cell use in a patient with an ischemic foot ulcer: a case study.

Journal Article J Vasc Nurs · June 2006 Stem cell research has been discussed in both the political and popular arenas lately. Some types of stem cell research are controversial; however, not all stem cell research involves harvesting cells from an embryo or an aborted fetus. Another type of ste ... Full text Link to item Cite

The coagulopathy of trauma versus disseminated intravascular coagulation.

Journal Article The Journal of trauma · June 2006 The coagulopathy of trauma is a syndrome of non-surgical bleeding from mucosal lesions, serosal surfaces, and wound and vascular access sites associated with serious injury, hypothermia, acidosis, hemodilution, and occasionally with classic disseminated in ... Cite

The clinical benefits of the leukoreduction of blood products

Journal Article Journal of Trauma - Injury, Infection and Critical Care · June 1, 2006 Full text Cite

The coagulopathy of trauma versus disseminated intravascular coagulation.

Journal Article J Trauma · June 2006 The coagulopathy of trauma is a syndrome of non-surgical bleeding from mucosal lesions, serosal surfaces, and wound and vascular access sites associated with serious injury, hypothermia, acidosis, hemodilution, and occasionally with classic disseminated in ... Full text Link to item Cite

Indications for early fresh frozen plasma, cryoprecipitate, and platelet transfusion in trauma

Journal Article Journal of Trauma - Injury, Infection and Critical Care · June 1, 2006 Cite

Early predictors of transfusion and mortality after injury: A review of the data-based literature

Journal Article Journal of Trauma - Injury, Infection and Critical Care · June 1, 2006 Full text Cite

Efficacy evaluation of current and future platelet transfusion products

Journal Article Journal of Trauma - Injury, Infection and Critical Care · June 1, 2006 Full text Cite

The clinical use and immunologic impact of thrombin in surgery.

Journal Article Semin Thromb Hemost · April 2006 Thrombin is a naturally derived enzyme that has been widely characterized for its roles in hemostasis, inflammation, and cell signaling. Thrombin has been purified from numerous sources and used as a clinical aid for topical hemostasis for more than 60 yea ... Full text Link to item Cite

Recombinant activated factor VII and the anaesthetist.

Journal Article Anaesthesia · December 2005 Recombinant activated factor VII is a safe and effective for the treatment and prevention of haemorrhage in haemophiliacs with circulating inhibitors to replacement factors, and patients with Glanzmann's thrombasthenia refractory to platelet transfusion. B ... Full text Link to item Cite

Giant cell arteritis manifesting as mesenteric ischemia.

Journal Article J Vasc Surg · November 2005 We report a case of giant cell arteritis in an 80-year-old woman who presented with chronic mesenteric ischemia to our vascular surgery service. Computed tomography, arteriography, and magnetic resonance angiography revealed long, smooth stenosis of the su ... Full text Link to item Cite

Consensus recommendations for the off-label use of recombinant human factor VIIa (NovoSeven®) therapy

Journal Article P and T · November 1, 2005 Objective: To rationalize decision-making concerning the growing and costly off-label use of recombinant human factor VII (rFVIIa, NovoSeven®) therapy. Options: Using rFVIIa therapy for patients with bleeding or providing usual care (e.g., continued clotti ... Cite

Reduction of vascular intimal-medial hyperplasia in polytetrafluoroethylene arteriovenous grafts via expression of an inhibitor of G protein signaling.

Journal Article Ann Vasc Surg · September 2005 Polytetrafluoroethylene (PTFE) arteriovenous (AV) grafts are performed routinely for vascular access. The limited life span of PTFE grafts is a major cause of morbidity. Graft failure is attributed to venous outflow tract vascular smooth muscle (VSM) hyper ... Full text Link to item Cite

Genetic modification of endothelial cells to improve vascular graft function

Conference Journal of the American College of Surgeons · September 2005 Full text Cite

Gene expression profiling to describe and model peripheral arterial disease

Conference Journal of the American College of Surgeons · September 2005 Full text Cite

Multicenter evaluation of the bovine mesenteric vein bioprostheses for hemodialysis access in patients with an earlier failed prosthetic graft.

Journal Article J Am Coll Surg · August 2005 BACKGROUND: The number of patients requiring hemodialysis increases each year, with a large cohort of patients still requiring prosthetic grafts for hemodialysis. All available prosthetic vascular access grafts have predictable failure rates, leading to a ... Full text Link to item Cite

Antihuman factor V antibodies after use of relatively pure bovine thrombin.

Journal Article Ann Thorac Surg · March 2005 Although bovine thrombin is commonly used in the operating room, there is evidence that exposure to bovine thrombin can result in the development of autoimmune antibodies, usually against factor V, which can lead to a profound coagulopathy. It is thought t ... Full text Link to item Cite

Axillary to common iliac arteriovenous graft for hemodialysis access: Case report and review of 'exotic' axillary-based grafts.

Journal Article J Vasc Access · 2005 A 58-year-old Caucasian male with end-stage renal disease and peripheral arterial disease was referred to us for management of his complex vascular access. His vascular access history included a left wrist primary fistula, a left upper arm access graft, a ... Full text Link to item Cite

Design of the Dialysis Access Consortium (DAC) Clopidogrel Prevention of Early AV Fistula Thrombosis Trial.

Journal Article Clin Trials · 2005 BACKGROUND: The Dialysis Access Consortium (DAC) was developed to investigate interventions to improve hemodialysis vascular access outcomes. The autogenous arteriovenous fistula created by direct connection of native artery to vein is the recommended vasc ... Full text Link to item Cite

Design of the Dialysis Access Consortium (DAC) Aggrenox Prevention Of Access Stenosis Trial.

Journal Article Clin Trials · 2005 BACKGROUND: Surgically created arteriovenous (AV) grafts are the most common type of hemodialysis vascular access in the United States, but fail frequently due to the development of venous stenosis. The Dialysis Access Consortium (DAC) Aggrenox Prevention ... Full text Link to item Cite

A review of the therapeutic uses of thrombin.

Journal Article Thromb Haemost · May 2004 Thrombin is the product of the hemostatic response essential to the conversion of fibrinogen to fibrin. In addition, it is also responsible for the aggregation of blood platelets in the formation of the "platelet plug" as well as the activation of factor V ... Full text Link to item Cite

Challenges for providing effective hemostasis in surgery and trauma.

Journal Article Semin Hematol · January 2004 Vascular injury, whether surgical or traumatic, triggers a complex series of regulatory events. The understanding of these events, their interdependence, and their effect on hemostasis and thrombosis, is slowly being unraveled. The current understanding of ... Full text Link to item Cite

Type I aortic dissection involving visceral arteries

Journal Article EJVES Extra · January 1, 2004 Full text Cite

Gene therapy in tissue-engineered blood vessels.

Journal Article Tissue Eng · December 2003 Cardiovascular disease is the leading cause of morbidity and mortality in Western society. More than 1 million arterial bypass procedures are performed annually in the United States, where either autologous veins or synthetic grafts are used to replace art ... Full text Link to item Cite

Relative purity of thrombin-based hemostatic agents used in surgery.

Journal Article J Am Coll Surg · October 2003 BACKGROUND: Hemostatic agents used in surgery contain thrombin isolated from either a bovine or human source. The use of thrombin derived from a bovine source has been associated with the development of an abnormal immune response, but a study of the immun ... Full text Link to item Cite

Hypercoagulable states and antithrombotic strategies in recurrent vascular access site thrombosis.

Journal Article J Vasc Surg · September 2003 Vascular access site thrombosis is a major cause of morbidity in patients receiving hemodialysis. The role of hypercoagulable states in recurrent vascular access site thrombosis remains poorly understood. Data are limited regarding systemic anticoagulation ... Full text Link to item Cite

Fibrin sealant improves hemostasis in peripheral vascular surgery: a randomized prospective trial.

Journal Article Ann Surg · June 2003 OBJECTIVE: To evaluate the efficacy and safety of an investigational fibrin sealant (FS) in a randomized prospective, partially blinded, controlled, multicenter trial. SUMMARY BACKGROUND DATA: Upper extremity vascular access surgery using polytetrafluoreth ... Full text Link to item Cite

Human arteries engineered in vitro.

Journal Article EMBO Rep · June 2003 There is a pressing need to develop methods to engineer small-calibre arteries for bypass surgery. We hypothesized that the rate-limiting step that has thwarted previous attempts to engineer such vessels from non-neonatal tissues is the limited proliferati ... Full text Link to item Cite

Protease-activated receptor-2 signaling triggers dendritic cell development.

Journal Article Am J Pathol · June 2003 Dendritic cells (DC) are potent antigen-presenting cells that govern the effector cell responses of the immune system. DC are thought to continuously develop from circulating progenitors in a process that is accelerated by inflammatory stimuli. However, th ... Full text Link to item Cite

Bovine thrombin and systemic autoimmunity.

Journal Article Am J Pathol · April 2003 Full text Link to item Cite

A porcine model of intimal-medial hyperplasia in polytetrafluoroethylene arteriovenous grafts.

Journal Article J Vasc Access · 2003 PURPOSE: Vascular access polytetrafluoroethylene (PTFE) graft failure is a major cause of morbidity in the hemodialysis population. The most common cause of graft failure is thrombosis secondary to stenosis at the venous outflow tract. Venous outflow steno ... Link to item Cite

Challenges of hemodialysis access for high risk patients: Impact of mesenteric vein bioprosthetic graft

Journal Article Journal of Vascular Access · January 1, 2003 Objective: The purpose of this study is to compare in a prospective fashion the performance of a new bioprosthesis, the mesenteric vein bioprosthesis (MVB), in patients who have had multiple failed ePTFE grafts. Performance measures include primary patency ... Full text Cite

Disseminated intravascular coagulation in association with pig-to-primate pulmonary xenotransplantation.

Journal Article Transplantation · June 15, 2002 Featured Publication BACKGROUND: Profound coagulopathy has been proposed as a barrier to xenotransplantation. Disseminated intravascular coagulation (DIC) has been observed with the rejection of renal and bone marrow xenografts but has not yet been described in pulmonary xenog ... Full text Link to item Cite

Antiphospholipid antibodies after surgical exposure to topical bovine thrombin.

Journal Article J Lab Clin Med · June 2002 Featured Publication Exposure to topical bovine thrombin during surgery frequently results in the development of antibodies to multiple protein and carbohydrate antigens. We investigated the frequency of increased levels of antibodies to cardiolipin and beta(2)-glycoprotein I ... Full text Link to item Cite

Generation of species cross-reactive aptamers using "toggle" SELEX.

Journal Article Mol Ther · December 2001 Species cross-reactivity facilitates the preclinical evaluation of potentially therapeutic molecules in animal models. Here we describe an in vitro selection strategy in which RNA ligands (aptamers) that bind both human and porcine thrombin were selected b ... Full text Link to item Cite

Exposure of mice to topical bovine thrombin induces systemic autoimmunity.

Journal Article Am J Pathol · November 2001 Featured Publication Bovine thrombin is used as an aid to hemostasis in medical and surgical procedures. At least 500,000 Americans are exposed to this therapeutic annually and reports suggest that exposure is associated with the development of autoreactive antibodies. To dete ... Full text Link to item Cite

A human CD46 transgenic pig model system for the study of discordant xenotransplantation.

Journal Article Transplantation · January 15, 2001 BACKGROUND: The chronic shortage in the supply of human organs available for allotransplantation has turned attention toward the use of animals as potential donors, with pigs as the most likely species under consideration. Hyperacute rejection, the initial ... Full text Link to item Cite

Immunologic impact and clinical outcomes after surgical exposure to bovine thrombin.

Journal Article Ann Surg · January 2001 Featured Publication OBJECTIVE: To determine prospectively the immunologic response and adverse clinical events in surgical patients exposed to bovine thrombin during cardiac surgical procedures. SUMMARY BACKGROUND DATA: Topical bovine thrombin is used extensively as a hemosta ... Full text Link to item Cite

Blocking the initiation of coagulation by RNA aptamers to factor VIIa.

Journal Article Thromb Haemost · November 2000 The tissue factor/factor VIIa complex is thought to be the primary initiator of most physiologic blood coagulation events. Because of its proximal role in this process, we sought to generate new inhibitors of tissue factor/factor VIIa activity by targeting ... Link to item Cite

Exposure to topical bovine thrombin during surgery elicits a response against the xenogeneic carbohydrate galactose alpha1-3galactose.

Journal Article J Clin Immunol · November 2000 Exposure of humans to topical bovine thrombin has been associated with development of antibodies against bovine and human coagulation factors and blood coagulation abnormalities. However, the nature of this humoral response is unknown. In this study, numer ... Full text Link to item Cite

Use of fibrin sealant as a hemostatic agent after liver biopsy in swine.

Journal Article J Vasc Interv Radiol · 2000 PURPOSE: To determine whether fibrin sealant injected into the tract created by liver biopsy can be used to decrease postprocedural bleeding. An innovative delivery system was used to deploy the fibrin sealant. MATERIALS AND METHODS: Fibrin sealant is a he ... Full text Link to item Cite

Mini-circuit cardiopulmonary bypass with vacuum assisted venous drainage: feasibility of an asanguineous prime in the neonate.

Journal Article Perfusion · September 1999 Conventional cardiopulmonary bypass (CPB) in neonates results in increased transfusion requirements and hemodilution. There has been little advancement in CPB for the neonatal population. There is evidence that increased priming volumes and blood product t ... Full text Link to item Cite

Infant cardiopulmonary bypass: a procoagulant state.

Journal Article Ann Thorac Surg · August 1999 BACKGROUND: Procoagulant activity after cardiopulmonary bypass (CPB) in infants may predispose to thrombotic and bleeding complications. The induction of tissue factor and prothrombinase activity on endothelial cell membranes is a primary step in the activ ... Full text Link to item Cite

Decreased fibrinolytic activity in porcine-to-primate cardiac xenotransplantation.

Journal Article Mol Med · September 1998 BACKGROUND: One major barrier to successful xenotransplantation is acute vascular rejection, a process pathologically characterized by microvascular thrombosis and diffuse fibrin deposition in transplant blood vessels. This pathologic picture may result fr ... Link to item Cite

The role of antibodies in acute vascular rejection of pig-to-baboon cardiac transplants.

Journal Article J Clin Invest · April 15, 1998 Long-term success in xenotransplantation is currently hampered by acute vascular rejection. The inciting cause of acute vascular rejection is not yet known; however, a variety of observations suggest that the humoral immune response of the recipient agains ... Full text Link to item Cite

The role of natural anti-Gal alpha 1-3Gal antibodies in hyperacute rejection of pig-to-baboon cardiac xenotransplants.

Journal Article Transpl Immunol · September 1997 Xenoreactive natural antibodies in humans and higher primates are directed predominantly at Gal alpha 1-3Gal. These antibodies are thought to initiate hyperacute rejection of porcine organ xenografts. The contribution of anti-Gal alpha 1-3Gal antibodies to ... Full text Link to item Cite

Swine lungs expressing human complement-regulatory proteins are protected against acute pulmonary dysfunction in a human plasma perfusion model.

Journal Article J Thorac Cardiovasc Surg · February 1997 UNLABELLED: Pulmonary transplantation is currently limited by the number of suitable cadaver donor lungs. For this reason, pulmonary xenotransplantation is currently being investigated. OBJECTIVE: Our goal was to assess the role of complement in pulmonary ... Full text Link to item Cite

Molecular barriers to xenotransplantation.

Journal Article Transplantation · August 15, 1996 Full text Link to item Cite

A model for the tissue factor pathway to thrombin. I. An empirical study.

Journal Article J Biol Chem · September 16, 1994 The activation of prothrombin, factor V, factor VIII, factor IX, and factor X by the tissue factor-factor VIIa complex, in vitro, in a system in which each precursor protein was present at plasma concentration, was evaluated using a combination of activity ... Link to item Cite

Cooperative interaction of divalent metal ions, substrate, and tissue factor with factor VIIa.

Journal Article Biochemistry · March 22, 1994 Factor VIIa-tissue factor (TF) complex formation in the presence of EDTA or divalent cations (Me2+) was investigated. The influence of Me2+ on the amidolytic activity of factor VIIa and factor VIIa-TF complex was evaluated using low molecular weight synthe ... Full text Link to item Cite

Complex-dependent inhibition of factor VIIa by antithrombin III and heparin.

Journal Article J Biol Chem · January 15, 1993 The regulation of the factor VIIa-tissue factor complex is essential for control of the hemostatic response. However, the role of the inhibitor antithrombin III in the regulation of factor VIIa has remained in question. The inhibition of factor VIIa activi ... Link to item Cite

Extrinsic pathway proteolytic activity.

Journal Article Methods Enzymol · 1993 Full text Link to item Cite

The role of the membrane in the expression of the vitamin K-dependent enzymes.

Journal Article Arch Pathol Lab Med · December 1992 The hemostatic response to vascular damage results in the focal generation of thrombin to produce a fibrin/platelet clot at the site of vascular injury. This regulated hemostatic response derives from the assembly and activity of enzyme complexes that are ... Link to item Cite

Surface-dependent hemostasis.

Journal Article Semin Hematol · July 1992 Link to item Cite

Aminonaphthalenesulfonamides, a new class of modifiable fluorescent detecting groups and their use in substrates for serine protease enzymes.

Journal Article Biochemistry · June 16, 1992 A series of new compounds, 6-amino-1-naphthalenesulfonamides (ANSN), were used as fluorescent detecting groups for substrates of amidases. These compounds have a high quantum fluorescent yield, and the sulfonyl moiety permits a large range of chemical modi ... Full text Link to item Cite

The evaluation of complex-dependent alterations in human factor VIIa.

Journal Article J Biol Chem · March 5, 1992 Factor VIIa is a plasma glycoprotein which, when bound to the integral membrane glycoprotein tissue factor, forms an enzymatic complex that is essential for normal hemostasis. We have developed a fluorescent substrate (6-(Mes-D-Leu-Gly-Arg)amino-1-naphthal ... Link to item Cite

Cooperative activation of human factor IX by the human extrinsic pathway of blood coagulation.

Journal Article J Biol Chem · June 15, 1991 The activation of human coagulation factor IX by human tissue factor.factor VIIa.PCPS.Ca2+ (TF.VIIa.PCPS.Ca2+) and factor Xa.PCPS.Ca2+ enzyme complexes was investigated. Reactions were performed in a highly purified system consisting of isolated human plas ... Link to item Cite

Isolation and characterization of an acquired antithrombin antibody.

Journal Article Blood · December 1, 1990 A 68-year-old man, following mitral valve replacement, presented with a low-grade chronic consumptive coagulopathy. Laboratory analysis showed mild fibrinolysis, minimal effect of coumadin therapy, and a prolonged thrombin time (greater than 150 seconds us ... Link to item Cite

Thoratec VAD system as a bridge to heart transplantation.

Journal Article J Heart Transplant · 1990 As of October 1988 the Thoratec ventricular assist device system was used in 72 heart transplant candidates at 20 medical centers in five countries. All patients were in imminent risk of dying before donor heart procurement, with a mean cardiac index of 1. ... Link to item Cite

In vivo evaluations of a new thromboresistant polyurethane for artificial heart blood pumps.

Journal Article J Thorac Cardiovasc Surg · February 1988 To reduce the risk of thromboembolic complications in prosthetic blood pumps, we have developed a new segmented polyurethane elastomer. This material is unique because its mechanical properties for long-term durability and surface properties for biocompati ... Link to item Cite

A seven-month survival of a calf with an artificial heart designed for human use.

Journal Article Artif Organs · May 1981 A Jarvik-7 type of pneumatic artificial heart, which was specifically designed to fit the anatomy and hemodynamic requirements of human patients, was implanted in a calf in an experiment to test the hemodynamic performance of the artificial heart. The expe ... Full text Link to item Cite

Reoperative surgery in calves with a total artificial heart.

Journal Article Int J Artif Organs · January 1980 Two surgical techniques have been developed in our laboratory to deal with identifiable problems in long-term artificial heart experiments. A right throacotomy is used to deal with problems such as extensive bleeding, which occur in the immediate postopera ... Link to item Cite

Six-month survival of a calf with an artificial heart.

Journal Article J Thorac Cardiovasc Surg · July 1979 A pneumatically powered artificial heart, constructed primarily from a polyurethane, was implanted in the chest of a calf and supported the calf for more than 6 months. The heart, which was designed to fit in the chest of a 90 kilogram calf, was able to su ... Link to item Cite

Recent advances with the total artificial heart.

Journal Article N Engl J Med · February 16, 1978 Full text Link to item Cite

The beat goes on: status of the artificial heart, 1977.

Journal Article Int J Artif Organs · January 1978 After two decades of continuous research on the artificial heart, survival times of experimental animals indicate that clinical application of such a device is definitely feasible. However, a number of problems remain to be solved. Durability of the device ... Link to item Cite