Scholars@Duke
Leila Mureebe

Leila Mureebe

Professor of Surgery
Surgery, Vascular and Endovascular Surgery
leila.mureebe@duke.edu
Box 3467 Med Ctr, Durham, NC 27710
7682B Hosp North Hafs Building, Durham, NC 27710
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Selected Publications

Mechanical thrombectomy of inferior vena cava filter-associated caval thrombosis using FlowTriever and ClotTriever systems.

Journal Article J Vasc Surg Venous Lymphat Disord · November 2023 OBJECTIVE: Chronically indwelling inferior vena cava filters (IVCFs) can have multiple adverse sequelae, including IVCF-associated thrombosis. The Inari ClotTriever and FlowTriever mechanical and aspiration thrombectomy systems (Inari Medical) can be used ... Full text Link to item Cite

Surgical Outcomes of Patients With Inferior Vena Cava Leiomyosarcoma

Journal Article Journal of Vascular Surgery · October 2023 Full text Cite

Factors associated with preference of choice of aortic aneurysm repair in the PReference for Open Versus Endovascular repair of AAA (PROVE-AAA) study.

Journal Article J Vasc Surg · December 2022 OBJECTIVE: Patients can choose between open repair and endovascular repair (EVAR) of abdominal aortic aneurysm (AAA). However, the factors associated with patient preference for one repair type over another are not well-characterized. Here we assess the fa ... Full text Link to item Cite

The Impact of Work Status and Age in Choosing Type of Abdominal Aortic Aneurysm Repair.

Journal Article J Surg Res · July 2022 INTRODUCTION: The PReferences for Open Versus Endovascular Repair of Abdominal Aortic Aneurysm (PROVE-AAA) trial aimed to determine the efficacy of a validated decision aid to enable better alignment between patient preference and their ultimate repair. We ... Full text Link to item Cite

Short-Term Concerns Primarily Determine Patient Preference for Abdominal Aortic Aneurysm Repair.

Journal Article J Surg Res · January 2022 INTRODUCTION: Abdominal aortic aneurysm (AAA) repair may be performed through open or endovascular approaches, but the factors influencing a patient's repair-type preference are not well characterized. Here we performed a qualitative analysis to better und ... Full text Link to item Cite

Exploring Factors Associated With Morbidity and Mortality in Patients With Do-Not-Resuscitate Orders: A National Surgical Quality Improvement Program Database Analysis Within Surgical Groups.

Journal Article Anesth Analg · February 1, 2021 BACKGROUND: Anesthesiologists caring for patients with do-not-resuscitate (DNR) orders may have ethical concerns because of their resuscitative wishes and may have clinical concerns because of their known increased risk of morbidity/mortality. Patient hete ... Full text Link to item Cite

FRAMING THE (VIDEO)CALL TO ACTION IN PRIMARY CARE WITHIN VISN 6

Conference JOURNAL OF GENERAL INTERNAL MEDICINE · 2021 Cite

Basic Angiography: Radiation Safety, Power Injector Use, and Image Intensifier Positioning

Chapter · January 1, 2021 Radiation safety is critically important for both patients and healthcare staff during diagnostic and therapeutic angiography. As technology advances, improvements in fluoroscopy equipment have reduced radiation exposure, but procedures have become more co ... Full text Cite

The Vascular Implant Surveillance and Interventional Outcomes (VISION) Coordinated Registry Network: An effort to advance evidence evaluation for vascular devices.

Journal Article J Vasc Surg · December 2020 The Vascular Implant Surveillance and Interventional Outcomes Network (VISION) is a Coordinated Registry Network (CRN) a member of Medical Device Epidemiology Network, a U.S. Food and Drug Administration (FDA)-supported global public-private partnership th ... Full text Link to item Cite

Development and Performance of a Clinical Decision Support Tool to Inform Resource Utilization for Elective Operations.

Journal Article JAMA Netw Open · November 2, 2020 IMPORTANCE: Hospitals ceased most elective procedures during the height of coronavirus disease 2019 (COVID-19) infections. As hospitals begin to recommence elective procedures, it is necessary to have a means to assess how resource intensive a given case m ... Full text Link to item Cite

Design of the PReferences for Open Versus Endovascular Repair of Abdominal Aortic Aneurysm (PROVE-AAA) Trial.

Journal Article Ann Vasc Surg · May 2020 For patients with abdominal aortic aneurysm (AAA), randomized trials have found endovascular AAA repair (EVAR) is associated with lower perioperative morbidity and mortality than open surgical repair (OSR). However, OSR has fewer long-term aneurysm-related ... Full text Link to item Cite

Assessing Quality of Surgical Real-World Data from an Automated Electronic Health Record Pipeline.

Journal Article J Am Coll Surg · March 2020 BACKGROUND: Significant analysis errors can be caused by nonvalidated data quality of electronic health records data. To determine surgical data fitness, a framework of foundational and study-specific data analyses was adapted and assessed using conformanc ... Full text Link to item Cite

Patient information sources when facing repair of abdominal aortic aneurysm.

Journal Article J Vasc Surg · February 2020 OBJECTIVE: Shared medical decision making is most important when there are competing options for repair such as in treatment of abdominal aortic aneurysm (AAA). We sought to understand the sources of patients' pre-existing knowledge about AAA to better inf ... Full text Link to item Cite

Assessing Quality of Real-World Data Supplied by an Automated Surgical Data Pipeline

Conference JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS · October 1, 2019 Link to item Cite

Carotid stenting and endarterectomy and contralateral carotid occlusion.

Journal Article J Vasc Surg · September 2019 BACKGROUND: The presence of contralateral carotid occlusion (CCO) has been controversial throughout the history of carotid intervention. Some studies cite a higher stroke risk in the setting of CCO, whereas other studies document no difference in stroke ri ... Full text Link to item Cite

Minimally Invasive Surgical Site Infection in Procedure-Targeted ACS NSQIP Pancreaticoduodenectomies.

Journal Article J Surg Res · January 2019 BACKGROUND: Pancreaticoduodenectomy (PD) incurs a surgical site infection rate of up to 18%. Published rates after minimally invasive PD are comparable or superior to open, but data are limited to high-volume, single-institution series. This study aimed to ... Full text Link to item Cite

Mechanical thrombectomy of inferior vena cava filter-associated caval thrombosis using FlowTriever and ClotTriever systems.

Journal Article J Vasc Surg Venous Lymphat Disord · November 2023 OBJECTIVE: Chronically indwelling inferior vena cava filters (IVCFs) can have multiple adverse sequelae, including IVCF-associated thrombosis. The Inari ClotTriever and FlowTriever mechanical and aspiration thrombectomy systems (Inari Medical) can be used ... Full text Link to item Cite

Surgical Outcomes of Patients With Inferior Vena Cava Leiomyosarcoma

Journal Article Journal of Vascular Surgery · October 2023 Full text Cite

Factors associated with preference of choice of aortic aneurysm repair in the PReference for Open Versus Endovascular repair of AAA (PROVE-AAA) study.

Journal Article J Vasc Surg · December 2022 OBJECTIVE: Patients can choose between open repair and endovascular repair (EVAR) of abdominal aortic aneurysm (AAA). However, the factors associated with patient preference for one repair type over another are not well-characterized. Here we assess the fa ... Full text Link to item Cite

The Impact of Work Status and Age in Choosing Type of Abdominal Aortic Aneurysm Repair.

Journal Article J Surg Res · July 2022 INTRODUCTION: The PReferences for Open Versus Endovascular Repair of Abdominal Aortic Aneurysm (PROVE-AAA) trial aimed to determine the efficacy of a validated decision aid to enable better alignment between patient preference and their ultimate repair. We ... Full text Link to item Cite

Short-Term Concerns Primarily Determine Patient Preference for Abdominal Aortic Aneurysm Repair.

Journal Article J Surg Res · January 2022 INTRODUCTION: Abdominal aortic aneurysm (AAA) repair may be performed through open or endovascular approaches, but the factors influencing a patient's repair-type preference are not well characterized. Here we performed a qualitative analysis to better und ... Full text Link to item Cite

Exploring Factors Associated With Morbidity and Mortality in Patients With Do-Not-Resuscitate Orders: A National Surgical Quality Improvement Program Database Analysis Within Surgical Groups.

Journal Article Anesth Analg · February 1, 2021 BACKGROUND: Anesthesiologists caring for patients with do-not-resuscitate (DNR) orders may have ethical concerns because of their resuscitative wishes and may have clinical concerns because of their known increased risk of morbidity/mortality. Patient hete ... Full text Link to item Cite

FRAMING THE (VIDEO)CALL TO ACTION IN PRIMARY CARE WITHIN VISN 6

Conference JOURNAL OF GENERAL INTERNAL MEDICINE · 2021 Cite

Basic Angiography: Radiation Safety, Power Injector Use, and Image Intensifier Positioning

Chapter · January 1, 2021 Radiation safety is critically important for both patients and healthcare staff during diagnostic and therapeutic angiography. As technology advances, improvements in fluoroscopy equipment have reduced radiation exposure, but procedures have become more co ... Full text Cite

The Vascular Implant Surveillance and Interventional Outcomes (VISION) Coordinated Registry Network: An effort to advance evidence evaluation for vascular devices.

Journal Article J Vasc Surg · December 2020 The Vascular Implant Surveillance and Interventional Outcomes Network (VISION) is a Coordinated Registry Network (CRN) a member of Medical Device Epidemiology Network, a U.S. Food and Drug Administration (FDA)-supported global public-private partnership th ... Full text Link to item Cite

Development and Performance of a Clinical Decision Support Tool to Inform Resource Utilization for Elective Operations.

Journal Article JAMA Netw Open · November 2, 2020 IMPORTANCE: Hospitals ceased most elective procedures during the height of coronavirus disease 2019 (COVID-19) infections. As hospitals begin to recommence elective procedures, it is necessary to have a means to assess how resource intensive a given case m ... Full text Link to item Cite

Design of the PReferences for Open Versus Endovascular Repair of Abdominal Aortic Aneurysm (PROVE-AAA) Trial.

Journal Article Ann Vasc Surg · May 2020 For patients with abdominal aortic aneurysm (AAA), randomized trials have found endovascular AAA repair (EVAR) is associated with lower perioperative morbidity and mortality than open surgical repair (OSR). However, OSR has fewer long-term aneurysm-related ... Full text Link to item Cite

Assessing Quality of Surgical Real-World Data from an Automated Electronic Health Record Pipeline.

Journal Article J Am Coll Surg · March 2020 BACKGROUND: Significant analysis errors can be caused by nonvalidated data quality of electronic health records data. To determine surgical data fitness, a framework of foundational and study-specific data analyses was adapted and assessed using conformanc ... Full text Link to item Cite

Patient information sources when facing repair of abdominal aortic aneurysm.

Journal Article J Vasc Surg · February 2020 OBJECTIVE: Shared medical decision making is most important when there are competing options for repair such as in treatment of abdominal aortic aneurysm (AAA). We sought to understand the sources of patients' pre-existing knowledge about AAA to better inf ... Full text Link to item Cite

Assessing Quality of Real-World Data Supplied by an Automated Surgical Data Pipeline

Conference JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS · October 1, 2019 Link to item Cite

Carotid stenting and endarterectomy and contralateral carotid occlusion.

Journal Article J Vasc Surg · September 2019 BACKGROUND: The presence of contralateral carotid occlusion (CCO) has been controversial throughout the history of carotid intervention. Some studies cite a higher stroke risk in the setting of CCO, whereas other studies document no difference in stroke ri ... Full text Link to item Cite

Minimally Invasive Surgical Site Infection in Procedure-Targeted ACS NSQIP Pancreaticoduodenectomies.

Journal Article J Surg Res · January 2019 BACKGROUND: Pancreaticoduodenectomy (PD) incurs a surgical site infection rate of up to 18%. Published rates after minimally invasive PD are comparable or superior to open, but data are limited to high-volume, single-institution series. This study aimed to ... Full text Link to item Cite

Low mortality rates after endovascular aortic repair expand use to high-risk patients.

Journal Article J Vasc Surg · February 2018 OBJECTIVE: The 2010 endovascular aneurysm repair (EVAR) trial 2 (EVAR 2) reported that patients with comorbidity profiles rendering them unfit for open aneurysm repair who underwent EVAR did not experience a survival advantage compared with those who did n ... Full text Link to item Cite

Vascular Complications and Use of a Distal Perfusion Cannula in Femorally Cannulated Patients on Extracorporeal Membrane Oxygenation.

Journal Article ASAIO J · 2018 Femoral arterial cannulation in adult venoarterial (VA) extracorporeal membrane oxygenation (ECMO) predisposes patients to ipsilateral limb ischemia. Placement of a distal perfusion catheter (DPC) is one of few techniques available to prevent or manage thi ... Full text Link to item Cite

Endovascular and Open Repair of Ruptured Infrarenal Aortic Aneurysms at a Tertiary Care Center.

Journal Article Ann Vasc Surg · May 2017 BACKGROUND: The mortality of ruptured abdominal aortic aneurysms (rAAAs) has been reported as high as 90%. Loss of consciousness and a systolic blood pressure of <80 mm Hg on presentation are the most important predictors of mortality after emergent open r ... Full text Link to item Cite

2016 AHA/ACC Guideline on the Management of Patients With Lower Extremity Peripheral Artery Disease: Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines.

Journal Article Circulation · March 21, 2017 UNLABELLED: Since 1980, the American College of Cardiology (ACC) and American Heart Association (AHA) have translated scientific evidence into clinical practice guidelines with recommendations to improve cardiovascular health. These guidelines, based on sy ... Full text Link to item Cite

2016 AHA/ACC Guideline on the Management of Patients With Lower Extremity Peripheral Artery Disease: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines.

Journal Article Circulation · March 21, 2017 UNLABELLED: Since 1980, the American College of Cardiology (ACC) and American Heart Association (AHA) have translated scientific evidence into clinical practice guidelines with recommendations to improve cardiovascular health. These guidelines, based on sy ... Full text Link to item Cite

Correction

Journal Article Journal of the American College of Cardiology · March 2017 Full text Cite

Laparotomy during endovascular repair of ruptured abdominal aortic aneurysms increases mortality.

Journal Article J Vasc Surg · February 2017 OBJECTIVE: Subset analyses from small case series suggest patients requiring laparotomy during endovascular repair of ruptured abdominal aortic aneurysms (REVAR) have worse survival than those undergoing REVAR without laparotomy. Most concomitant laparotom ... Full text Link to item Cite

Operative and perioperative management of infected arteriovenous grafts.

Journal Article J Vasc Access · January 18, 2017 Vascular graft infections are a particularly troublesome complication for dialysis patients, many of whom are in an already immunocompromised state. The objective of this review is to detail the risk factors, etiology, diagnosis, perioperative and operativ ... Full text Link to item Cite

Perioperative Optimization of Geriatric Lower Extremity Bypass in the Era of Increased Performance Accountability.

Journal Article Ann Vasc Surg · January 2017 BACKGROUND: The initiation of bundled payment for care improvement by Centers for Medicare and Medicaid Services (CMS) has led to increased financial and performance accountability. As most vascular surgery patients are elderly and reimbursed via CMS, impr ... Full text Link to item Cite

Gonadal Vein Transposition in the Treatment of Nutcracker Syndrome

Conference Journal of Vascular Surgery · September 2016 Full text Cite

Urgent workup of lower gastrointestinal bleeding

Chapter · January 1, 2016 Lower gastrointestinal bleeding occurs at a rate of 20 cases per 100,000 persons per year with a similar overall mortality to upper gastrointestinal bleeding. Prognosis is favorable, with the majority of bleeding episodes ceasing without intervention. The ... Full text Cite

Eversion Versus Conventional Carotid Endarterectomy: Both Winners

Conference Journal of Vascular Surgery · June 2015 Full text Cite

Complications of indwelling retrievable versus permanent inferior vena cava filters DISCUSSION

Journal Article JOURNAL OF VASCULAR SURGERY-VENOUS AND LYMPHATIC DISORDERS · April 1, 2014 Link to item Cite

Spliced Arm Vein Grafts for Critical Lower Limb Ischemia

Conference Journal of Vascular Surgery · December 2012 Full text Cite

A novel scoring system for predicting postoperative venous thromboembolic complications in patients after open aortic surgery.

Journal Article J Am Coll Surg · April 2012 BACKGROUND: Although the overall incidence of venous thromboembolism (VTE) after open aortic surgery is low, it is not known whether specific factors can place patients at increased risk for this complication. The goal of our study was to identify patient ... Full text Link to item Cite

Direct thrombin inhibitors.

Journal Article J Cardiovasc Pharmacol Ther · March 2012 Cardiovascular disease is a leading cause of death and pathologic coagulation plays an integral role in the development, propagation, and intervention of cardiovascular disease. The 2 classic anticoagulants, heparin and vitamin K antagonists, though having ... Full text Link to item Cite

A 53-Year-Old female with lower abdominal pain

Journal Article Journal of Surgical Radiology · December 1, 2011 Cite

Reply

Other Journal of Vascular Surgery · January 1, 2011 Full text Cite

Urgent workup of lower GI bleeding

Chapter · December 1, 2010 Lower gastrointestinal bleeding (LGIB) is defined as bleeding originating from bowel distal to the ligament of Treitz. LGIB presents as either melena or hematochezia, depending on the source and the rapidity of hemorrhage. The most common cause of blood pe ... Full text Cite

Gender trends in the repair of ruptured abdominal aortic aneurysms and outcomes.

Journal Article J Vasc Surg · April 2010 BACKGROUND: This study evaluated gender-specific trends in the diagnosis and treatment of ruptured abdominal aortic aneurysms (rAAAs) in the United States Medicare population. METHODS: The Medicare beneficiary database (1995 through 2006) was examined for ... Full text Link to item Cite

Current insights on the biology and clinical aspects of VEGF regulation.

Journal Article Vasc Endovascular Surg · December 2008 Vascular endothelial growth factor (VEGF) is a key molecule that orchestrates the formation and function of vascular networks. Impaired regulation of angiogenesis is implicated in a number of pathologic states. For instance, neoplasias exhibit uncontrolled ... Full text Link to item Cite

National trends in the repair of ruptured abdominal aortic aneurysms.

Journal Article J Vasc Surg · November 2008 OBJECTIVE: This study evaluated trends in hospitalizations, treatment, and mortality of ruptured abdominal aortic aneurysms (rAAAs) in the United States Medicare population. METHODS: The Medicare inpatient database (1995 through 2006) was reviewed for pati ... Full text Link to item Cite

The impact of recent European trials on abdominal aortic aneurysm repair: is a paradigm shift warranted?

Journal Article J Surg Res · August 2008 Recent reports, following upon the reported outcomes of European randomized prospective trials of endovascular abdominal aortic aneurysm repair (EVAR), have brought into question the appropriateness of some of the trials' main conclusions, particularly in ... Full text Link to item Cite

Periprocedural complication rates are equivalent between symptomatic and asymptomatic patients undergoing carotid angioplasty and stenting.

Journal Article Ann Vasc Surg · March 2008 Patients with neurologic symptoms who undergo carotid endarterectomy (CEA) have a higher incidence of stroke and death in the perioperative period than those with asymptomatic carotid disease. This study examines the outcomes of symptomatic and asymptomati ... Full text Link to item Cite

Risk of heparin-induced thrombocytopenia from heparin-bonded vascular prostheses.

Journal Article Ann Vasc Surg · November 2007 Heparin can be bonded to vascular devices to improve their patency. The purpose of this study was to determine if a clinically utilized heparin-bonded Dacron((R)) graft (HBG) places patients at risk for heparin-induced thrombocytopenia (HIT) and its compli ... Full text Link to item Cite

Direct thrombin inhibitors: alternatives to heparin.

Journal Article Vascular · 2007 After more than 70 years of effective clinical use, heparin remains the most common anticoagulant in use and one of the most commonly prescribed drugs to hospitalized patients. However, the biologic variability and immunogenicity limit its utility. With in ... Full text Link to item Cite

Analysis of outcomes following failed endovascular treatment of chronic limb ischemia.

Journal Article Ann Vasc Surg · July 2006 Despite recent studies highlighting the advantages of endoluminal intervention in the management of chronic limb ischemia (CLI), outcomes following failed peripheral angioplasty remain less well described. We present a retrospective analysis of failed tran ... Full text Link to item Cite

Abdominal aortic aneurysm in women: Should they be screened?

Conference JOURNAL OF ENDOVASCULAR THERAPY · February 1, 2006 Link to item Cite

Infrainguinal arterial intervention: is there a role for an atherectomy device?

Journal Article Vascular · 2006 Excision of atheromatous plaque is an attractive option for the minimally invasive treatment of peripheral arterial disease. Approved for use in 2003, the SilverHawk Plaque Exicison System (FoxHollow Technologies, Redwood City, CA) is a catheter-based plaq ... Full text Link to item Cite

Platelet function and pharmacologic inhibition.

Journal Article Vasc Endovascular Surg · 2006 Platelets have traditionally been understood within the context of hemostasis and hemorrhagic disorders. However, with increasing procedures being performed in smaller vessels and with an increasing incidence of atherosclerosis, the often critical role pla ... Full text Link to item Cite

Analysis of anatomic factors and age in patients undergoing carotid angioplasty and stenting.

Journal Article Ann Vasc Surg · November 2005 Recent data suggest that patient age >80 years may be associated with increased risk of periprocedural complications from carotid angioplasty and stenting (CAS). In this study, we analyzed anatomic risk factors in patients undergoing CAS based on age >80 o ... Full text Link to item Cite

Argatroban for anticoagulation during cardiopulmonary bypass in an infant.

Journal Article Paediatr Anaesth · April 2005 Heparin induced thrombocytopenia (HIT) is a rare, but potentially life-threatening complication of heparin therapy. In patients with HIT, alternative means of anticoagulation are necessary. The authors present an infant with HIT who required anticoagulatio ... Full text Link to item Cite

Heparin-induced thrombocytopenia in the pediatric intensive care unit population.

Journal Article Pediatr Crit Care Med · March 2005 OBJECTIVES: To report the occurrence of heparin-induced thrombocytopenia (HIT), discuss its pathophysiology, and outline an approach to management in the pediatric intensive care unit (ICU) patient. DESIGN: Retrospective case reports. SETTING: Pediatric IC ... Full text Link to item Cite

Hypercoagulable states: a review.

Journal Article Vasc Endovascular Surg · 2005 Vascular surgeons are often asked to evaluate patients with recurrent thromboses or thromboses in unusual locations either arterial or venous. There may be obvious inciting factors, but in many of these patients the possibility of a previously undiagnosed ... Full text Link to item Cite

Pharmacomechanical thrombectomy for treatment of symptomatic lower extremity deep venous thrombosis: safety and feasibility study.

Journal Article J Vasc Surg · November 2004 PURPOSE: The current standard of care for deep venous thromboembolism (DVT) is anticoagulation; however, this treatment method does not rapidly relieve clot burden or clinical symptoms. We describe a rapid and effective method of thrombus removal, with sim ... Full text Link to item Cite

Heparin-associated antiplatelet antibodies increase morbidity and mortality in hemodialysis patients.

Journal Article Surgery · October 2004 BACKGROUND: Patients are frequently exposed to heparin during hemodialysis (HD) to prevent thrombosis of the extracorporeal circuit. Other groups with frequent heparin exposures have a high rate of development of heparin-associated antiplatelet antibodies ... Full text Link to item Cite

Inhibition of intimal hyperplasia by direct thrombin inhibitors in an animal vein bypass model.

Journal Article Ann Vasc Surg · March 2004 Many functions of the coagulation system have nonthrombotic effects. The indirect thrombin inhibitor heparin has been previously shown to be effective in limiting intimal hyperplasia (IH). We sought to study the effect of thrombin on IH by using two direct ... Full text Link to item Cite

Role of race and sex in diagnosis and one-year follow up of deep venous thrombosis.

Journal Article Surg Technol Int · 2004 This study examines the role of sex and race in the diagnosis and outcome of deep vein thrombosis (DVT). A retrospective study was performed of 632 patients who underwent venous duplex ultrasound from August 1998 to July 1999. Comparisons were made by Chi- ... Link to item Cite

Calciphylaxis: a poor prognostic indicator for limb salvage.

Journal Article J Vasc Surg · June 2001 INTRODUCTION: Calciphylaxis (calcific uremic arteriolopathy) is a rare complication of end-stage renal disease in patients with secondary hyperparathyroidism. Subcutaneous skin nodules and extensive tissue necrosis with vascular calcification characterize ... Full text Link to item Cite

Epidemiology, risk factors, and management of peripheral vascular disease.

Journal Article Ostomy Wound Manage · September 1998 Peripheral vascular occlusive disease is initiated with a genetic risk factor component compounded by patient-controlled contributions including obesity, diabetes, hypertension, and smoking. Medical management of these factors may delay or obviate surgical ... Link to item Cite

Wound infection: a physician's perspective.

Journal Article Ostomy Wound Manage · August 1998 Infection in a wound represents a colony count of 10(5) or greater. Contamination is the presence of many surface organisms. Moist wound healing, not dehydration, protects and prepares the wound for coverage and closure. Relief of pain is a critical factor ... Link to item Cite

Differential diagnosis: Assessment of the lower-extremity ulcer - Is it arterial, venous, neuropathic?

Journal Article Wounds · July 1, 1998 A non-healing ulcer of the lower extremity may be multifactorial in origin. The classic description includes: an ulcer superior to the medial malleolus usually indicating venous disease; ulceration of the anterior tibial surface as reflective of blood dysc ... Cite

Smooth muscle cell migration and proliferation are mediated by distinct phases of activation of the intracellular messenger mitogen-activated protein kinase.

Journal Article J Vasc Surg · January 1998 PURPOSE: Mitogen-activated protein kinase (MAPK) is a ubiquitous signaling protein that has been associated with cellular proliferation; however, its role in cellular migration has not been established. In this study, we investigate the role of MAPK in pla ... Full text Link to item Cite

Activation of pp60c-src is necessary for human vascular smooth muscle cell migration.

Journal Article Surgery · August 1997 BACKGROUND: The most widely distributed nonreceptor tyrosine kinase is pp60c-src (src), yet the role of this intracellular signaling protein in cell migration has not been defined. Given that smooth muscle cell (SMC) migration is essential for the developm ... Full text Link to item Cite

The role of integrins in saphenous vein vascular smooth muscle cell migration.

Journal Article Journal of vascular surgery · June 1997 PurposeSmooth muscle cell (SMC) migration is an essential feature of the intimal hyperplastic process that so frequently limits the patency of vascular reconstructions. The purpose of this investigation was to evaluate the effect of a series of in ... Full text Cite

Differential effects of platelet-derived growth factor isotypes on human smooth muscle cell proliferation and migration are mediated by distinct signaling pathways.

Journal Article Surgery · August 1996 BACKGROUND: Platelet-derived growth factor (PDGF) is a potent mitogen and chemoattractant for vascular smooth muscle cells (SMCs). Three isotypes of PDGF (BB, AB, and AA) have been identified; each of these isotypes may have differing effects on the behavi ... Full text Link to item Cite

Popliteal artery injury after total knee arthroplasty.

Journal Article Am Surg · May 1996 Total knee arthroplasty (TKA) is a commonly performed orthopedic procedure. The incidence of vascular complications after TKA is low. However, these complications may be debilitating, limb-threatening, and potentially avoidable. Our first patient, who had ... Link to item Cite