Scholars@Duke
Lihong Wang

Lihong Wang

Adjunct Assistant Professor in the Department of Psychiatry and Behavioral Sciences
Psychiatry & Behavioral Sciences, Adult Psychiatry & Psychology
lihong.wang@duke.edu
Box 3918 Med Ctr, Durham, NC 27710
Dept of Rad, Durham, NC 27710

Selected Publications

The differential orbitofrontal activity and connectivity between atypical and typical major depressive disorder

Journal Article NeuroImage: Clinical · January 1, 2025 Objective: Atypical major depressive disorder (MDD) is a distinct subtype of MDD, characterized by increased appetite and/or weight gain, excessive sleep, leaden paralysis, and interpersonal rejection sensitivity. Delineating different neural circuits asso ... Full text Cite

Hybrid representation learning for cognitive diagnosis in late-life depression over 5 years with structural MRI.

Journal Article Med Image Anal · May 2024 Late-life depression (LLD) is a highly prevalent mood disorder occurring in older adults and is frequently accompanied by cognitive impairment (CI). Studies have shown that LLD may increase the risk of Alzheimer's disease (AD). However, the heterogeneity o ... Full text Link to item Cite

Brain Anatomy-Guided MRI Analysis for Assessing Clinical Progression of Cognitive Impairment with Structural MRI.

Conference Med Image Comput Comput Assist Interv · October 2023 Brain structural MRI has been widely used for assessing future progression of cognitive impairment (CI) based on learning-based methods. Previous studies generally suffer from the limited number of labeled training data, while there exists a huge amount of ... Full text Link to item Cite

Functional Connectivity Analysis of Visually Evoked ERPs for Mild Cognitive Impairment: Pilot Study.

Conference Annu Int Conf IEEE Eng Med Biol Soc · July 2023 Mild cognitive impairment (MCI) is considered the early stage of Alzheimer's disease, characterized as mild memory loss. A novel method of functional connectivity (FC) analysis can be used to detect MCI before memory is significantly impaired allowing for ... Full text Link to item Cite

Signal Processing Methods of Enhanced Magnetic Memory Testing

Journal Article Processes · February 1, 2023 As a particular kind of detection technology under weak magnetization, metal magnetic memory testing is very likely to be affected by external factors in the detecting process, which may lead to incorrect results. In order to minimize the negative influenc ... Full text Cite

Brain morphometric features predict depression symptom phenotypes in late-life depression using a deep learning model.

Journal Article Front Neurosci · 2023 OBJECTIVES: Our objective was to use deep learning models to identify underlying brain regions associated with depression symptom phenotypes in late-life depression (LLD). PARTICIPANTS: Diagnosed with LLD (N = 116) and enrolled in a prospective treatment s ... Full text Link to item Cite

The neurobiology of apathy in depression and neurocognitive impairment in older adults: a review of epidemiological, clinical, neuropsychological and biological research.

Journal Article Transl Psychiatry · December 26, 2022 Apathy is a common condition that involves diminished initiative, diminished interest and diminished emotional expression or responsiveness. It is highly prevalent in the context of a variety of neuropsychiatric disorders and is related to poor health outc ... Full text Link to item Cite

Understanding Clinical Progression of Late-Life Depression to Alzheimer's Disease Over 5 Years with Structural MRI.

Conference Mach Learn Med Imaging · September 2022 Previous studies have shown that late-life depression (LLD) may be a precursor of neurodegenerative diseases and may increase the risk of dementia. At present, the pathological relationship between LLD and dementia, in particularly Alzheimer's disease (AD) ... Full text Link to item Cite

Forward model of metal magnetic memory testing based on equivalent surface magnetic charge theory

Journal Article Wuli Xuebao/Acta Physica Sinica · August 5, 2022 The magnetic dipole theory has been widely and successfully used to qualitatively analyze the testing signals of metal magnetic memory (MMM) testing. However, the magnetic charge density of the existing models is always an assumed value distributed uniform ... Full text Cite

Effect and neural mechanisms of the transcutaneous vagus nerve stimulation for relapse prevention in patients with remitted major depressive disorder: protocol for a longitudinal study.

Journal Article BMJ Open · February 22, 2022 INTRODUCTION: After the first episode, patients with remitted major depressive disorder (MDD) have a 60% chance of experiencing a second episode. There are currently no accepted, effective methods to prevent the recurrence of MDD in remission. Transcutaneo ... Full text Link to item Cite

Cognitive variability, brain aging, and cognitive decline in late-life major depression.

Journal Article Int J Geriatr Psychiatry · May 2021 OBJECTIVES: Older adults with late-life major depression (LLMD) are at increased risk of dementia. Dispersion, or within-person performance variability across cognitive tests, is a potential marker of cognitive decline. This study examined group difference ... Full text Link to item Cite

Structural brain changes and neuroticism in late-life depression: a neural basis for depression subtypes.

Journal Article International psychogeriatrics · May 2021 The neurobiological basis of neuroticism in late-life depression (LLD) is understudied. We hypothesized that older depressed subjects scoring high in measures of neuroticism would have smaller hippocampal and prefrontal volumes compared with non-neurotic o ... Full text Cite

Deep factor regression for computer-aided analysis of major depressive disorders with structural MRI data

Conference Proceedings - International Symposium on Biomedical Imaging · April 13, 2021 Major depressive disorder (MDD) is a prevalent and debilitating psychiatric mood disorder that affects millions of people worldwide. Conventional methods for MDD severity diagnosis usually rely on neuropsychological assessments that are subjective and susc ... Full text Cite

Functional connectivity predictors of acute depression treatment outcome.

Journal Article International psychogeriatrics · December 2019 Few studies have examined functional connectivity (FC) patterns using functional magnetic resonance imaging (fMRI) to predict outcomes in late-life depression. We hypothesized that FC within and between frontal and limbic regions would be associated with 1 ... Full text Cite

Improving brain function of pediatric acute lymphoblastic leukemia patients after induction chemotherapy, a pilot self-contrast study by fractional amplitude of low-frequency fluctuation.

Journal Article J Clin Neurosci · August 2019 Our previous study revealed altered resting-stated brain function in children with acute lymphoblastic leukemia (ALL) on new-onset stage. To investigate the effects after induction chemotherapy, a pilot self-contrast study was conducted to compare the diff ... Full text Link to item Cite

Exploring common changes after acute mental stress and acute tryptophan depletion: Resting-state fMRI studies.

Journal Article J Psychiatr Res · June 2019 Stress and low serotonin levels are important biological factors in depression and anxiety etiologies. Although studies indicate that low serotonin levels, stress, and other factors may interact in depression/anxiety psychopathology, few studies have inves ... Full text Link to item Cite

Increased ventromedial prefrontal cortex activity and connectivity predict poor sertraline treatment outcome in late-life depression.

Journal Article Int J Geriatr Psychiatry · May 2019 OBJECTIVE: Previous studies of imaging predictors on acute treatment response in late-life depression (LLD) demonstrated that poor response to selective serotonin reuptake inhibitors (SSRIs) is associated with pre-treatment low functional connectivity (FC) ... Full text Link to item Cite

Resting-state mapping of neural signatures of vulnerability to depression relapse.

Journal Article J Affect Disord · May 1, 2019 BACKGROUND: Patients with major depressive disorder (MDD) can frequently develop new depressive episodes after remission. However, the neural mechanisms underlying the increased risk for depressive relapse remain unclear. Herein, we aimed to explore whethe ... Full text Link to item Cite

Neurodegenerative disorders

Chapter · April 23, 2019 Cite

Role of inflammation in depression relapse.

Journal Article J Neuroinflammation · April 17, 2019 Major depressive disorder (MDD) is a leading cause of disability worldwide. After the first episode, patients with remitted MDD have a 60% chance of experiencing a second episode. Consideration of therapy continuation should be viewed in terms of the balan ... Full text Link to item Cite

Recent advances in the use of imaging in psychiatry: functional magnetic resonance imaging of large-scale brain networks in late-life depression.

Journal Article F1000Res · 2019 Advances in neuroimaging have identified neural systems that contribute to clinical symptoms that occur across various psychiatric disorders. This transdiagnostic approach to understanding psychiatric illnesses may serve as a precise guide to identifying d ... Full text Link to item Cite

Physical exercise increases involvement of motor networks as a compensatory mechanism during a cognitively challenging task.

Journal Article Int J Geriatr Psychiatry · August 2018 OBJECTIVE: Neuroimaging studies suggest that older adults may compensate for declines in cognitive function through neural compensation and reorganization of neural resources. While neural compensation as a key component of cognitive reserve is an importan ... Full text Link to item Cite

Increased salience network activity in patients with insomnia complaints in major depressive disorder

Journal Article Frontiers in Psychiatry · March 20, 2018 Background: Insomnia is one of the main symptom correlates of major depressive disorder (MDD), but the neural mechanisms underlying the multifaceted interplay between insomnia and depression are not fully understood. Materials and methods: Patients with MD ... Full text Cite

A new measure for neural compensation is positively correlated with working memory and gait speed

Journal Article Frontiers in Aging Neuroscience · March 19, 2018 Neuroimaging studies suggest that older adults may compensate for declines in brain function and cognition through reorganization of neural resources. A limitation of prior research is reliance on between-group comparisons of neural activation (e.g., young ... Full text Cite

Dual-TRACER: High resolution fMRI with constrained evolution reconstruction.

Journal Article Neuroimage · January 1, 2018 fMRI with high spatial resolution is beneficial for studies in psychology and neuroscience, but is limited by various factors such as prolonged imaging time, low signal to noise ratio and scarcity of advanced facilities. Compressed Sensing (CS) based metho ... Full text Link to item Cite

Negative Affectivity, Aging, and Depression: Results From the Neurobiology of Late-Life Depression (NBOLD) Study.

Journal Article Am J Geriatr Psychiatry · October 2017 OBJECTIVE: Neuroticism is a common yet understudied condition in older adults. We hypothesized that presence of high negativity affectivity (NA), a key feature of neuroticism, would be associated with different prefrontal cortex (PFC) activity and connecti ... Full text Link to item Cite

Altered brain function in new onset childhood acute lymphoblastic leukemia before chemotherapy: A resting-state fMRI study.

Journal Article Brain Dev · October 2017 OBJECTIVE: Cognitive impairments had been reported in childhood acute lymphoblastic leukemia, what caused the impairments needed to be demonstrated, chemotherapy-related or the disease itself. The primary aim of this exploratory investigation was to determ ... Full text Link to item Cite

Task difficulty modulates brain activation in the emotional oddball task.

Journal Article Brain Res · June 1, 2017 Previous functional magnetic resonance imaging (fMRI) studies have reported that task-irrelevant, emotionally salient events can disrupt target discrimination, particularly when attentional demands are low, while others demonstrate alterations in the distr ... Full text Open Access Link to item Cite

Decreased Resting-State Activity in the Precuneus Is Associated With Depressive Episodes in Recurrent Depression.

Journal Article J Clin Psychiatry · April 2017 OBJECTIVE: To investigate alterations in resting-state spontaneous brain activity in patients with major depressive disorder (MDD) experiencing multiple episodes. METHODS: Between May 2007 and September 2014, 24 recurrent and 22 remitted patients diagnosed ... Full text Link to item Cite

Maintenance and Representation of Mind Wandering during Resting-State fMRI.

Journal Article Sci Rep · January 12, 2017 Major advances in resting-state functional magnetic resonance imaging (fMRI) techniques in the last two decades have provided a tool to better understand the functional organization of the brain both in health and illness. Despite such developments, charac ... Full text Open Access Link to item Cite

Decreased between-hemisphere connectivity strength and network efficiency in geriatric depression.

Journal Article Hum Brain Mapp · January 2017 White matter (WM) lesions have been recognized as a key etiological factor in geriatric depression. However, little is known about the topological pattern changes of WM in geriatric depression in the remitted state (RGD) and its relationship to depressive ... Full text Link to item Cite

Multiple Neuroimaging Measures for Examining Exercise-induced Neuroplasticity in Older Adults: A Quasi-experimental Study.

Journal Article Front Aging Neurosci · 2017 Physical exercise can improve physical and mental health. A number of imaging studies have examined the role of neuroplasticity in improving cognition with physical exercise; however, such neuroplasticity changes are not consistent across the reports partl ... Full text Link to item Cite

Does elicitation method matter? Behavioral and neuroimaging evidence from capacity allocation game

Journal Article Production and Operations Management · May 1, 2016 To date, it has not been elucidated whether the strategy method and the direct-response method lead to different behaviors in experiments of economic games. In this study, we investigate this issue under a multi-round setting of the capacity allocation gam ... Full text Cite

[Brain injury after induction chemotherapy in children with acute lymphoblastic leukemia].

Journal Article Zhongguo Dang Dai Er Ke Za Zhi · March 2016 OBJECTIVE: To investigate the changes in brain injury after the induction chemotherapy in children with acute lymphoblastic leukemia (ALL) by cranial MRI. METHODS: The clinical data and cranial MRI results of 62 children with ALL who were hospitalized from ... Full text Link to item Cite

Atomic connectomics signatures for characterization and differentiation of mild cognitive impairment.

Journal Article Brain Imaging Behav · December 2015 In recent years, functional connectomics signatures have been shown to be a very valuable tool in characterizing and differentiating brain disorders from normal controls. However, if the functional connectivity alterations in a brain disease are localized ... Full text Link to item Cite

Abnormal degree centrality of functional hubs associated with negative coping in older Chinese adults who lost their only child.

Journal Article Biol Psychol · December 2015 The loss of an only child is a negative life event and may potentially increase the risk of psychiatric disorders. However, the psychological consequences of the loss of an only child and the associated neural mechanisms remain largely unexplored. Degree c ... Full text Link to item Cite

Abnormal spontaneous neural activity in the anterior insular and anterior cingulate cortices in anxious depression.

Journal Article Behav Brain Res · March 15, 2015 OBJECTIVE: Anxious depression is a distinct clinical subtype of major depressive disorder (MDD) characterized by palpitations, somatic complaints, altered interoceptive awareness, high risk of suicide, and poor response to pharmacotherapy. However, the neu ... Full text Link to item Cite

Altered Synchronizations among Neural Networks in Geriatric Depression.

Journal Article Biomed Res Int · 2015 Although major depression has been considered as a manifestation of discoordinated activity between affective and cognitive neural networks, only a few studies have examined the relationships among neural networks directly. Because of the known disconnecti ... Full text Link to item Cite

Predictive models of resting state networks for assessment of altered functional connectivity in mild cognitive impairment.

Journal Article Brain Imaging Behav · December 2014 Due to the difficulties in establishing correspondences between functional regions across individuals and populations, systematic elucidation of functional connectivity alterations in mild cognitive impairment (MCI) in comparison with normal controls (NC) ... Full text Link to item Cite

Connectome-scale assessments of structural and functional connectivity in MCI.

Journal Article Hum Brain Mapp · July 2014 Mild cognitive impairment (MCI) has received increasing attention not only because of its potential as a precursor for Alzheimer's disease but also as a predictor of conversion to other neurodegenerative diseases. Although MCI has been defined clinically, ... Full text Link to item Cite

Neural correlates of cognitive and affective processing in maltreated youth with posttraumatic stress symptoms: does gender matter?

Journal Article Dev Psychopathol · May 2014 We investigated the relationship of gender to cognitive and affective processing in maltreated youth with posttraumatic stress disorder symptoms using functional magnetic resonance imaging. Maltreated (N = 29, 13 females, 16 males) and nonmaltreated partic ... Full text Link to item Cite

[The impact of mood on the intrinsic functional connectivity].

Journal Article Sheng Wu Yi Xue Gong Cheng Xue Za Zhi · April 2014 Although a great number of studies have investigated the changes of resting-state functional connectivity (rsFC) in patients with mental disorders, such as depression and schizophrenia etc, little is known how stable the changes are, and whether temporal s ... Link to item Cite

Group-constrained sparse fMRI connectivity modeling for mild cognitive impairment identification.

Journal Article Brain Struct Funct · March 2014 Emergence of advanced network analysis techniques utilizing resting-state functional magnetic resonance imaging (R-fMRI) has enabled a more comprehensive understanding of neurological disorders at a whole-brain level. However, inferring brain connectivity ... Full text Link to item Cite

Neural mechanisms of risky decision-making and reward response in adolescent onset cannabis use disorder.

Journal Article Drug Alcohol Depend · November 1, 2013 BACKGROUND: Neural mechanisms of decision-making and reward response in adolescent cannabis use disorder (CUD) are underexplored. METHODS: Three groups of male adolescents were studied: CUD in full remission (n=15); controls with psychopathology without su ... Full text Link to item Cite

Ventromedial prefrontal cortex encodes emotional value.

Journal Article J Neurosci · July 3, 2013 The ventromedial prefrontal cortex (vmPFC) plays a critical role in processing appetitive stimuli. Recent investigations have shown that reward value signals in the vmPFC can be altered by emotion regulation processes; however, to what extent the processin ... Full text Link to item Cite

Fine-granularity functional interaction signatures for characterization of brain conditions.

Journal Article Neuroinformatics · July 2013 In the human brain, functional activity occurs at multiple spatial scales. Current studies on functional brain networks and their alterations in brain diseases via resting-state functional magnetic resonance imaging (rs-fMRI) are generally either at local ... Full text Link to item Cite

DICCCOL: dense individualized and common connectivity-based cortical landmarks.

Journal Article Cereb Cortex · April 2013 Is there a common structural and functional cortical architecture that can be quantitatively encoded and precisely reproduced across individuals and populations? This question is still largely unanswered due to the vast complexity, variability, and nonline ... Full text Link to item Cite

Frontoparietal attentional network activation differs between smokers and nonsmokers during affective cognition.

Journal Article Psychiatry Res · January 30, 2013 Smoking withdrawal-induced disruption of affect and cognition is associated with dysregulated prefrontal brain function, although little is known regarding the neural foci of smoker-nonsmoker differences during affective cognition. Thus, the current study ... Full text Link to item Cite

Automated segmentation of CBCT image using spiral CT atlases and convex optimization.

Journal Article Med Image Comput Comput Assist Interv · 2013 Cone-beam computed tomography (CBCT) is an increasingly utilized imaging modality for the diagnosis and treatment planning of the patients with craniomaxillofacial (CMF) deformities. CBCT scans have relatively low cost and low radiation dose in comparison ... Full text Link to item Cite

Integration of sparse multi-modality representation and geometrical constraint for isointense infant brain segmentation.

Journal Article Med Image Comput Comput Assist Interv · 2013 Segmentation of infant brain MR images is challenging due to insufficient image quality, severe partial volume effect, and ongoing maturation and myelination process. During the first year of life, the signal contrast between white matter (WM) and gray mat ... Full text Link to item Cite

Multi-atlas based simultaneous labeling of longitudinal dynamic cortical surfaces in infants.

Journal Article Med Image Comput Comput Assist Interv · 2013 Accurate and consistent labeling of longitudinal cortical surfaces is essential to understand the early dynamic development of cortical structure and function in both normal and abnormal infant brains. In this paper, we propose a novel method for simultane ... Full text Link to item Cite

Low-rank total variation for image super-resolution.

Journal Article Med Image Comput Comput Assist Interv · 2013 Most natural images can be approximated using their low-rank components. This fact has'been successfully exploited in recent advancements of matrix completion algorithms for image recovery. However, a major limitation of low-rank matrix completion algorith ... Full text Link to item Cite

Psychological and neural mechanisms of trait mindfulness in reducing depression vulnerability.

Journal Article Soc Cogn Affect Neurosci · January 2013 Mindfulness-based interventions are effective for reducing depressive symptoms. However, the psychological and neural mechanisms are unclear. This study examined which facets of trait mindfulness offer protection against negative bias and rumination, which ... Full text Link to item Cite

Loss of sustained activity in the ventromedial prefrontal cortex in response to repeated stress in individuals with early-life emotional abuse: implications for depression vulnerability.

Journal Article Front Psychol · 2013 Repeated psychosocial stress in early-life has significant impact on both behavior and neural function which, together, increase vulnerability to depression. However, neural mechanisms related to repeated stress remain unclear. We hypothesize that early-li ... Full text Link to item Cite

Electrophysiological correlates of fearful and sad distraction on target processing in adolescents with attention deficit-hyperactivity symptoms and affective disorders

Journal Article Frontiers in Integrative Neuroscience · November 30, 2012 In this study we used event-related brain potentials (ERP) as neural markers of cognitive operations to examine emotion and attentional processing in a population of high-risk adolescents with mental health problems that included ADHD, anxiety, and depress ... Full text Cite

Neural correlates associated with cognitive decline in late-life depression.

Journal Article Am J Geriatr Psychiatry · August 2012 OBJECTIVES: Persistent cognitive impairment (PCI) after remission of depressive symptoms is a major adverse outcome of late-life depression (LLD). The purpose of this study was to examine neural substrates associated with PCI in LLD. DESIGN: Longitudinal s ... Full text Link to item Cite

Smoking abstinence and depressive symptoms modulate the executive control system during emotional information processing.

Journal Article Addict Biol · May 2012 Smoking abstinence disrupts affective and cognitive processes. In this study, functional magnetic resonance imaging (fMRI) was used to investigate the effects of smoking abstinence on emotional information processing. Smokers (n = 17) and non-smokers (n = ... Full text Link to item Cite

Impact of BDNF Val66Met and 5-HTTLPR polymorphism variants on neural substrates related to sadness and executive function.

Journal Article Genes Brain Behav · April 2012 The brain-derived neurotrophic factor (BDNF) Val(66) Met allelic variation is linked to both the occurrence of mood disorders and antidepressant response. These findings are not universally observed, and the mechanism by which this variation results in inc ... Full text Link to item Cite

Nicotine withdrawal modulates frontal brain function during an affective Stroop task.

Journal Article Psychopharmacology (Berl) · April 2012 BACKGROUND: Among nicotine-dependent smokers, smoking abstinence disrupts multiple cognitive and affective processes including conflict resolution and emotional information processing (EIP). However, the neurobiological basis of abstinence effects on resol ... Full text Link to item Cite

Identification of MCI individuals using structural and functional connectivity networks.

Journal Article Neuroimage · February 1, 2012 Different imaging modalities provide essential complementary information that can be used to enhance our understanding of brain disorders. This study focuses on integrating multiple imaging modalities to identify individuals at risk for mild cognitive impa ... Full text Link to item Cite

Brain imaging investigation of the impairing effect of emotion on cognition.

Journal Article J Vis Exp · February 1, 2012 Emotions can impact cognition by exerting both enhancing (e.g., better memory for emotional events) and impairing (e.g., increased emotional distractibility) effects (reviewed in (1)). Complementing our recent protocol (2) describing a method that allows i ... Full text Link to item Cite

Atlas construction via dictionary learning and group sparsity.

Journal Article Med Image Comput Comput Assist Interv · 2012 Atlas construction generally includes first an image registration step to normalize all images into a common space and then an atlas building step to fuse all the aligned images. Although numerous atlas construction studies have been performed to improve t ... Full text Link to item Cite

Constrained sparse functional connectivity networks for MCI classification.

Journal Article Med Image Comput Comput Assist Interv · 2012 Mild cognitive impairment (MCI) is difficult to diagnose due to its subtlety. Recent emergence of advanced network analysis techniques utilizing resting-state functional Magnetic Resonance Imaging (rs-fMRI) has made the understanding of neurological disord ... Full text Link to item Cite

Resting-state multi-spectrum functional connectivity networks for identification of MCI patients.

Journal Article PLoS One · 2012 In this paper, a high-dimensional pattern classification framework, based on functional associations between brain regions during resting-state, is proposed to accurately identify MCI individuals from subjects who experience normal aging. The proposed tech ... Full text Link to item Cite

Constrained sparse functional connectivity networks for MCI classification

Journal Article Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) · January 1, 2012 © Springer-Verlag Berlin Heidelberg 2012. Mild cognitive impairment (MCI) is difficult to diagnose due to its subtlety. Recent emergence of advanced network analysis techniques utilizing resting-state functional Magnetic Resonance Imaging (rs-fMRI) has mad ... Cite

Delivering happiness: translating positive psychology intervention research for treating major and minor depressive disorders.

Journal Article J Altern Complement Med · August 2011 Despite the availability of many treatment options, depressive disorders remain a global public health problem. Even in affluent nations, 70% of reported cases either do not receive the recommended level of treatment or do not get treated at all, and this ... Full text Link to item Cite

Functional imaging of emotion reactivity in opiate-dependent borderline personality disorder.

Journal Article Personal Disord · July 2011 Opiate dependence (OD) and borderline personality disorder (BPD), separately and together, are significant public health problems with poor treatment outcomes. BPD is associated with difficulties in emotion regulation, and brain-imaging studies in BPD indi ... Full text Link to item Cite

Enriched white matter connectivity networks for accurate identification of MCI patients.

Journal Article Neuroimage · February 1, 2011 Mild cognitive impairment (MCI), often a prodromal phase of Alzheimer's disease (AD), is frequently considered to be a good target for early diagnosis and therapeutic interventions of AD. Recent emergence of reliable network characterization techniques has ... Full text Link to item Cite

Learning-based meta-algorithm for MRI brain extraction.

Journal Article Med Image Comput Comput Assist Interv · 2011 Multiple-segmentation-and-fusion method has been widely used for brain extraction, tissue segmentation, and region of interest (ROI) localization. However, such studies are hindered in practice by their computational complexity, mainly coming from the step ... Full text Link to item Cite

Altered cerebellar-cerebral functional connectivity in geriatric depression.

Journal Article PLoS One · 2011 Although volumetric and activation changes in the cerebellum have frequently been reported in studies on major depression, its role in the neural mechanism of depression remains unclear. To understand how the cerebellum may relate to affective and cognitiv ... Full text Link to item Cite

Structural integrity of the uncinate fasciculus and resting state functional connectivity of the ventral prefrontal cortex in late life depression.

Journal Article PLoS One · 2011 BACKGROUND: Neuroimaging studies in late life depression have reported decreased structural integrity of white matter tracts in the prefrontal cortex. Functional studies have identified changes in functional connectivity among several key areas involved in ... Full text Link to item Cite

Identification of individuals with MCI via multimodality connectivity networks.

Journal Article Med Image Comput Comput Assist Interv · 2011 Alzheimer's disease (AD), is difficult to diagnose due to the subtlety of cognitive impairment. Recent emergence of reliable network characterization techniques based on diffusion tensor imaging (DTI) and resting-state functional magnetic resonance imaging ... Full text Link to item Cite

The impact of anxiety-inducing distraction on cognitive performance: a combined brain imaging and personality investigation.

Journal Article PLoS One · November 30, 2010 BACKGROUND: Previous investigations revealed that the impact of task-irrelevant emotional distraction on ongoing goal-oriented cognitive processing is linked to opposite patterns of activation in emotional and perceptual vs. cognitive control/executive bra ... Full text Open Access Link to item Cite

Scan-rescan reliability of subcortical brain volumes derived from automated segmentation.

Journal Article Hum Brain Mapp · November 2010 Large-scale longitudinal studies of regional brain volume require reliable quantification using automated segmentation and labeling. However, repeated MR scanning of the same subject, even if using the same scanner and acquisition parameters, does not resu ... Full text Open Access Link to item Cite

Accurate identification of MCI patients via enriched white-matter connectivity network

Journal Article Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) · October 25, 2010 Mild cognitive impairment (MCI), often a prodromal phase of Alzheimer's disease (AD), is frequently considered to be a good target for early diagnosis and therapeutic interventions of AD. Recent emergence of reliable network characterization techniques hav ... Full text Cite

Toward discovery science of human brain function.

Journal Article Proc Natl Acad Sci U S A · March 9, 2010 Although it is being successfully implemented for exploration of the genome, discovery science has eluded the functional neuroimaging community. The core challenge remains the development of common paradigms for interrogating the myriad functional systems ... Full text Link to item Cite

The effect of acute tryptophan depletion on emotional distraction and subsequent memory.

Journal Article Soc Cogn Affect Neurosci · December 2009 Serotonin is a key neurotransmitter involved in emotional regulation and memory. A number of studies using acute tryptophan depletion (ATD) in healthy subjects have shown that a temporary serotonin reduction both induces a negative emotional bias and impai ... Full text Link to item Cite

Alterations in cortical thickness and white matter integrity in mild cognitive impairment measured by whole-brain cortical thickness mapping and diffusion tensor imaging.

Journal Article AJNR Am J Neuroradiol · May 2009 BACKGROUND AND PURPOSE: Mild cognitive impairment (MCI) is a risk factor for Alzheimer disease and can be difficult to diagnose because of the subtlety of symptoms. This study attempted to examine gray matter (GM) and white matter (WM) changes with cortica ... Full text Link to item Cite

Prefrontal mechanisms for executive control over emotional distraction are altered in major depression.

Journal Article Psychiatry Res · July 15, 2008 A dysfunction in the interaction between executive function and mood regulation has been proposed as the pathophysiology of depression. However, few studies have investigated the alteration in brain systems related to executive control over emotional distr ... Full text Link to item Cite

Depressive state- and disease-related alterations in neural responses to affective and executive challenges in geriatric depression.

Journal Article Am J Psychiatry · July 2008 OBJECTIVE: Geriatric depression has been associated with a heterogeneous neuropathology. Identifying both depressive state-related and disease-related alterations in brain regions associated with emotion and cognitive function could provide useful diagnost ... Full text Link to item Cite

Opposing influences of emotional and non-emotional distracters upon sustained prefrontal cortex activity during a delayed-response working memory task.

Journal Article Neuropsychologia · January 15, 2008 Performance in delayed-response working memory (WM) tasks is typically associated with sustained activation in the dorsolateral prefrontal cortex (dlPFC) that spans the delay between the memoranda and the memory probe. Recent studies have demonstrated that ... Full text Link to item Cite

Neural substrates for processing task-irrelevant sad images in adolescents.

Journal Article Dev Sci · January 2008 Neural systems related to cognitive and emotional processing were examined in adolescents using event-related functional magnetic resonance imaging (fMRI). Ten healthy adolescents performed an emotional oddball task. Subjects detected infrequent circles (t ... Full text Link to item Cite

Prognostic value of posteromedial cortex deactivation in mild cognitive impairment.

Journal Article PLoS One · October 31, 2007 BACKGROUND: Normal subjects deactivate specific brain regions, notably the posteromedial cortex (PMC), during many tasks. Recent cross-sectional functional magnetic resonance imaging (fMRI) data suggests that deactivation during memory tasks is impaired in ... Full text Link to item Cite

Cortical deactivation in mild cognitive impairment: high-field-strength functional MR imaging.

Journal Article Radiology · October 2007 PURPOSE: To prospectively identify brain regions in which task-related changes in activation during a memory encoding task, measured with functional magnetic resonance (MR) imaging, correlate with degree of memory impairment across Alzheimer disease (AD), ... Full text Link to item Cite

Effect of bupropion extended release on negative emotion processing in major depressive disorder: a pilot functional magnetic resonance imaging study.

Journal Article J Clin Psychiatry · February 2007 BACKGROUND: Prior imaging studies suggest that patients with major depressive disorder have abnormalities in frontal and limbic neural circuitry including the amygdala, which is relatively more activated at rest and in response to negative emotional stimul ... Full text Link to item Cite

Mood alters amygdala activation to sad distractors during an attentional task.

Journal Article Biol Psychiatry · November 15, 2006 BACKGROUND: A behavioral hallmark of mood disorders is biased perception and memory for sad events. The amygdala is poised to mediate internal mood and external event processing because of its connections with both the internal milieu and the sensory world ... Full text Link to item Cite

Role of the inferior frontal cortex in coping with distracting emotions.

Journal Article Neuroreport · October 23, 2006 The role of inferior frontal cortex in coping with emotional distracters presented concurrently with a working memory task was investigated using event-related functional magnetic resonance imaging. The study yielded two main findings: (i) processing of em ... Full text Link to item Cite

Visual event-related potentials under different interstimulus intervals in Parkinson's disease: relation to motor disability, WAIS-R, and regional cerebral blood flow.

Journal Article Parkinsonism Relat Disord · June 2005 We have introduced S1-S2 paradigm (task S) as well as oddball paradigm (task O) visual event-related potentials (ERPs) under different interstimulus intervals (ISIs) in Parkinson's disease (PD). ERP measurements were correlated with motor disability, WAIS- ... Full text Link to item Cite

Amygdala activation to sad pictures during high-field (4 tesla) functional magnetic resonance imaging.

Journal Article Emotion · March 2005 Fear-related processing in the amygdala has been well documented, but its role in signaling other emotions remains controversial. The authors recovered signal loss in the amygdala at high-field strength using an inward spiral pulse sequence and probed its ... Full text Link to item Cite

Event-related potentials during visual S1-S2 paradigm in multiple system atrophy: relation to morphologic changes on brain MRI measurement.

Journal Article Parkinsonism Relat Disord · December 2003 Although mild cognitive deficits in multiple system atrophy (MSA) have been proved on neuropsychological testing, the cognitive function in MSA has not been investigated sufficiently from an electrophysiological view point. We performed a visual Event-rela ... Full text Link to item Cite

Spatiotemporal separability in the human cortical response to visual motion speed: a magnetoencephalography study.

Journal Article Neurosci Res · September 2003 Humans can estimate the speed of an object's motion independently of other visual information. Although speed-related neural activity is known to exist in the primate brain, there has been no physiological study that investigated where and how the speed of ... Full text Link to item Cite

Early sensory information processes are enhanced on visual oddball and S1-S2 tasks in Parkinson's disease: a visual event-related potentials study.

Journal Article Parkinsonism Relat Disord · August 2003 To observe sensory and cognitive information processing in Parkinson's disease (PD), 34 PD patients and 26 controls were investigated. A visual oddball paradigm and an S1-S2 paradigm were employed to record the early (P1, N1, P2) and late (N2, P3) event-re ... Full text Link to item Cite

Visual event-related potential changes in two subtypes of multiple system atrophy, MSA-C and MSA-P.

Journal Article J Neurol · August 2002 We investigated the visual event-related potentials (ERPs) in two subtypes of multisystem atrophy (MSA) in 15 MSA-C patients, 12 MSA-P patients, and 21 normal control (NC) subjects. We used a visual oddball task to elicit ERPs. No significant changes were ... Full text Link to item Cite

A magnetoencephalographic study on Wisconsin Card Sorting Test

Journal Article International Congress Series · April 1, 2002 Using magnetoencephalography (MEG), we studied temporal and spatial processing during performance of the Wisconsin Card Sorting Test (WCST) in 12 normal subjects. The MEG responses were compared between the first wrong and the fourth correct feedback both ... Full text Cite

A first comparison of the human multifocal visual evoked magnetic field and visual evoked potential.

Journal Article Neurosci Lett · November 23, 2001 Our objectives were to determine the feasibility of recording reliable multifocal visual evoked magnetic fields (mfVEFs), to investigate the maximum stimulus eccentricity for which the mfVEF responses can be obtained, and to study how this changes with che ... Full text Link to item Cite

Neural activities during Wisconsin Card Sorting Test--MEG observation.

Journal Article Brain Res Cogn Brain Res · August 2001 The present study recorded activities of magnetoencephalography (MEG) to the presentation of cards, and to the presentation of feedback signals in 12 normal subjects while they performed the Wisconsin Card Sorting Test (WCST), to observe temporal and spati ... Full text Link to item Cite

Do P1 and N1 evoked by the ERP task reflect primary visual processing in Parkinson's disease?

Journal Article Doc Ophthalmol · March 2001 OBJECTIVES: To evaluate whether P1 and N1 evoked by ERP tasks could appropriately reflect primary visual processing in Parkinson's disease (PD). METHODS: We recorded ERPs in 13 PD patients with duration of illness less than 5 years and 18 age-matched norma ... Link to item Cite

A contact lens electrode with built-in high intensity white light-emitting diodes. A contact lens electrode with built-in white LEDs.

Journal Article Doc Ophthalmol · January 2001 We determined the clinical usefulness of a new contact lens electrode with built-in, white light-emitting diodes (LEDs) for full-field electroretinograms (ERGs). Three, high-brightness white LEDs were incorporated into a contact lens electrode and served a ... Link to item Cite

Visual event-related potentials in progressive supranuclear palsy, corticobasal degeneration, striatonigral degeneration, and Parkinson's disease.

Journal Article J Neurol · May 2000 To determine whether there are characteristic changes in event-related potentials (ERPs) in parkinsonian syndromes we studied 8 patients with progressive supranuclear palsy (PSP), 10 patients with corticobasal degeneration (CBD), 9 patients with striatonig ... Full text Link to item Cite

The correlation between P300 alterations and regional cerebral blood flow in non-demented Parkinson's disease.

Journal Article Neurosci Lett · March 24, 2000 P300 was evoked by a visual oddball and an S1-S2 task in 22 non-demented Parkinson's disease (PD) patients (13 in the early stage, nine in the late stage) and 18 normal controls. Reaction time was also measured. All patients undertook the (99)Tc-ECD SPECT ... Full text Link to item Cite

Effect of interstimulus interval on visual P300 in Parkinson's disease.

Journal Article J Neurol Neurosurg Psychiatry · October 1999 OBJECTIVE: Visual event related potentials (ERPs) were studied during an oddball paradigm, to testify whether cognitive slowing in Parkinson's disease exists and to investigate whether cognitive information processing can be influenced by different interst ... Full text Link to item Cite

Visual event-related potential changes at two different tasks in nondemented Parkinson's disease.

Journal Article J Neurol Sci · April 1, 1999 A visual oddball paradigm and an S1-S2 paradigm were employed to evoke event-related potentials (ERPs) in 38 nondemented Parkinson's disease (PD) patients and 24 healthy elderly subjects. Delayed N200 and reduced P300 amplitude in the whole PD sample were ... Full text Link to item Cite