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Maggie Sweitzer

Associate Professor in Psychiatry and Behavioral Sciences
Psychiatry & Behavioral Sciences, Behavioral Medicine & Neurosciences

Selected Publications


Reactions to reduced nicotine content cigarettes in a sample of young adult, low-frequency smokers.

Journal Article Psychopharmacology (Berl) · September 2021 RATIONALE: Reducing nicotine content in cigarettes to ≤ 2.4 mg per g of tobacco [mg/g] reduces smoking behavior and toxicant exposure among adult daily smokers. However, cigarettes with similar nicotine content could support continued experimentation and s ... Full text Link to item Cite

The Effects of Nicotine and Tobacco Use on Brain Reward Function: Interaction With Nicotine Dependence Severity.

Journal Article Nicotine Tob Res · May 21, 2019 INTRODUCTION: This study investigated the effects of nicotine/tobacco on neural activation during performance of a monetary incentive delay task. AIMS AND METHODS: Prior to each scan, nonsmokers received nicotine or placebo nasal spray, and smokers were sm ... Full text Link to item Cite

ADHD, Smoking Withdrawal, and Inhibitory Control: Results of a Neuroimaging Study with Methylphenidate Challenge.

Journal Article Neuropsychopharmacology · March 2018 Smoking withdrawal negatively impacts inhibitory control, and these effects are greater for smokers with preexisting attention problems, such as attention deficit/hyperactivity disorder (ADHD). The current study preliminarily evaluated changes in inhibitor ... Full text Link to item Cite

A Primer on Foraging and the Explore/Exploit Trade-Off for Psychiatry Research.

Journal Article Neuropsychopharmacology · September 2017 Foraging is a fundamental behavior, and many types of animals appear to have solved foraging problems using a shared set of mechanisms. Perhaps the most common foraging problem is the choice between exploiting a familiar option for a known reward and explo ... Full text Link to item Cite

Smoking environment cues reduce ability to resist smoking as measured by a delay to smoking task.

Journal Article Addict Behav · April 2017 INTRODUCTION: Environments associated with smoking may promote lapse and relapse in smokers attempting to quit. Here we examined the effects of exposure to visual smoking environment cues on smoking urge and the ability to resist smoking, as measured with ... Full text Link to item Cite

Association Between Baseline Corticothalamic-Mediated Inhibitory Control and Smoking Relapse Vulnerability.

Journal Article JAMA Psychiatry · April 1, 2017 IMPORTANCE: Tobacco use disorder is associated with dysregulated neurocognitive function in the right inferior frontal gyrus (IFG)-one node in a corticothalamic inhibitory control (IC) network. OBJECTIVE: To examine associations between IC neural circuitry ... Full text Link to item Cite

Smoking Abstinence-Induced Changes in Resting State Functional Connectivity with Ventral Striatum Predict Lapse During a Quit Attempt.

Journal Article Neuropsychopharmacology · September 2016 The ventral and dorsal striatum are critical substrates of reward processing and motivation and have been repeatedly linked to addictive disorders, including nicotine dependence. However, little is known about how functional connectivity between these and ... Full text Link to item Cite

The effects of nicotine and non-nicotine smoking factors on working memory and associated brain function.

Journal Article Addict Biol · July 2016 Smoking abstinence impairs executive function, which may promote continued smoking behavior and relapse. The differential influence of nicotine and non-nicotine (i.e. sensory, motor) smoking factors and related neural substrates is not known. In a fully fa ... Full text Link to item Cite

Non-cigarette tobacco and poly-tobacco use among persons living with HIV drawn from a nationally representative sample.

Journal Article Drug Alcohol Depend · May 1, 2016 INTRODUCTION: Smoking is more prevalent among persons living with HIV (PLWH) than the general population. Little is known about the prevalence of non-cigarette tobacco and poly-tobacco use (PTU; using multiple tobacco products) among this population, which ... Full text Link to item Cite

Blunted striatal response to monetary reward anticipation during smoking abstinence predicts lapse during a contingency-managed quit attempt.

Journal Article Psychopharmacology (Berl) · March 2016 RATIONALE: Tobacco smoking is associated with dysregulated reward processing within the striatum, characterized by hypersensitivity to smoking rewards and hyposensitivity to non-smoking rewards. This bias toward smoking reward at the expense of alternative ... Full text Link to item Cite

Hippocampal and Insular Response to Smoking-Related Environments: Neuroimaging Evidence for Drug-Context Effects in Nicotine Dependence.

Journal Article Neuropsychopharmacology · February 2016 Environments associated with prior drug use provoke craving and drug taking, and set the stage for lapse/relapse. Although the neurobehavioral bases of environment-induced drug taking have been investigated with animal models, the influence of drug-environ ... Full text Link to item Cite

"I Use Weed for My ADHD": A Qualitative Analysis of Online Forum Discussions on Cannabis Use and ADHD.

Journal Article PLoS One · 2016 BACKGROUND: Attention-deficit/hyperactivity disorder (ADHD) is a risk factor for problematic cannabis use. However, clinical and anecdotal evidence suggest an increasingly popular perception that cannabis is therapeutic for ADHD, including via online resou ... Full text Open Access Link to item Cite

Increased Functional Connectivity in an Insula-Based Network is Associated with Improved Smoking Cessation Outcomes.

Journal Article Neuropsychopharmacology · October 2015 Little is known regarding the underlying neurobiology of smoking cessation. Neuroimaging studies indicate a role for the insula in connecting the interoceptive awareness of tobacco craving with a larger brain network that motivates smoking. We investigated ... Full text Link to item Cite

Smoking abstinence and neurocognition: implications for cessation and relapse.

Journal Article Curr Top Behav Neurosci · 2015 In this chapter, we review the last decade of research on the effects of smoking abstinence on various forms of neurocognition, including executive function (working memory, sustained attention, response inhibition), reward processing, and cue-reactivity. ... Full text Link to item Cite

Dissociated effects of anticipating smoking versus monetary reward in the caudate as a function of smoking abstinence.

Journal Article Biol Psychiatry · November 1, 2014 BACKGROUND: Theories of addiction suggest that chronic smoking may be associated with both hypersensitivity to smoking and related cues and hyposensitivity to alternative reinforcers. However, neural responses to smoking and nonsmoking rewards are rarely e ... Full text Link to item Cite

Polymorphic variation in the dopamine D4 receptor predicts delay discounting as a function of childhood socioeconomic status: evidence for differential susceptibility.

Journal Article Soc Cogn Affect Neurosci · June 2013 Inconsistent or null findings among studies associating behaviors on the externalizing spectrum--addictions, impulsivity, risk-taking, novelty-seeking traits--with presence of the 7-repeat allele of a common length polymorphism in the gene encoding the dop ... Full text Link to item Cite

Imaging genetics and the neurobiological basis of individual differences in vulnerability to addiction.

Journal Article Drug Alcohol Depend · June 2012 BACKGROUND: Addictive disorders are heritable, but the search for candidate functional polymorphisms playing an etiological role in addiction is hindered by complexity of the phenotype and the variety of factors interacting to impact behavior. Advances in ... Full text Link to item Cite