Scholars@Duke
Daniel Benjamin Mark

Daniel Benjamin Mark

Professor of Medicine
Medicine, Cardiology
daniel.mark@duke.edu
Duke Box 3485, Durham, NC 27710
300 West Morgan St, Durham, NC 27701

Selected Publications

Relationship Between Severity of Ischemia and Coronary Artery Disease for Different Stress Test Modalities in the ISCHEMIA Trial.

Journal Article Circ Cardiovasc Interv · December 2024 BACKGROUND: The relationship between the extent and severity of stress-induced ischemia and the extent and severity of anatomic coronary artery disease (CAD) in patients with obstructive CAD is multifactorial and includes the intensity of stress achieved, ... Full text Link to item Cite

RAndomized Cluster Evaluation of Cardiac ARrest Systems (RACE-CARS) trial: Study rationale and design.

Journal Article Am Heart J · November 2024 Out-of-hospital cardiac arrest (OHCA) occurs in nearly 350,000 people each year in the United States (US). Despite advances in pre and in-hospital care, OHCA survival remains low and is highly variable across systems and regions. The critical barrier to im ... Full text Open Access Link to item Cite

Public access defibrillator locations and details in Forsyth County, North Carolina: Results of a telephone survey canvas of large businesses to facilitate out-of-hospital cardiac arrest treatment.

Journal Article Am J Emerg Med · November 2024 BACKGROUND: Limited data are available on locations of public access defibrillation programs across communities in the United States, despite their widespread presence. Our goal was to determine publicly available AED locations of large businesses in a mix ... Full text Link to item Cite

Outcomes with revascularisation versus conservative management of participants with 3-vessel coronary artery disease in the ISCHEMIA trial.

Journal Article EuroIntervention · October 21, 2024 BACKGROUND: Whether revascularisation (REV) improves outcomes in patients with three-vessel coronary artery disease (3V-CAD) is uncertain. AIMS: Our objective was to evaluate outcomes with REV (percutaneous coronary intervention [PCI] or coronary artery by ... Full text Link to item Cite

Atherosclerosis quantification and cardiovascular risk: the ISCHEMIA trial.

Journal Article Eur Heart J · September 29, 2024 BACKGROUND AND AIMS: The aim of this study was to determine the prognostic value of coronary computed tomography angiography (CCTA)-derived atherosclerotic plaque analysis in ISCHEMIA. METHODS: Atherosclerosis imaging quantitative computed tomography (AI-Q ... Full text Link to item Cite

Edetate Disodium-Based Chelation for Patients With a Previous Myocardial Infarction and Diabetes: TACT2 Randomized Clinical Trial.

Journal Article JAMA · September 10, 2024 IMPORTANCE: In 2013, the Trial to Assess Chelation Therapy (TACT) reported that edetate disodium (EDTA)-based chelation significantly reduced cardiovascular disease (CVD) events by 18% in 1708 patients with a prior myocardial infarction (MI). OBJECTIVE: To ... Full text Link to item Cite

Forecasting the Economic Burden of Cardiovascular Disease and Stroke in the United States Through 2050: A Presidential Advisory From the American Heart Association.

Journal Article Circulation · July 23, 2024 BACKGROUND: Quantifying the economic burden of cardiovascular disease and stroke over the coming decades may inform policy, health system, and community-level interventions for prevention and treatment. METHODS: We used nationally representative health, ec ... Full text Link to item Cite

Baseline characteristics including blood and urine metal levels in the Trial to Assess Chelation Therapy 2 (TACT2).

Journal Article Am Heart J · July 2024 BACKGROUND: The reduction in cardiovascular disease (CVD) events with edetate disodium (EDTA) in the Trial to Assess Chelation Therapy (TACT) suggested that chelation of toxic metals might provide novel opportunities to reduce CVD in patients with diabetes ... Full text Link to item Cite

Combinations of First Responder and Drone Delivery to Achieve 5-Minute AED Deployment in OHCA.

Journal Article JACC Adv · July 2024 BACKGROUND: Defibrillation in the critical first minutes of out-of-hospital cardiac arrest (OHCA) can significantly improve survival. However, timely access to automated external defibrillators (AEDs) remains a barrier. OBJECTIVES: The authors estimated th ... Full text Link to item Cite

Prognostic Impact of Sinus Rhythm in Atrial Fibrillation Patients: Separating Rhythm Outcomes From Randomized Strategy Findings From the CABANA Trial.

Journal Article Circ Arrhythm Electrophysiol · May 2024 BACKGROUND: Clinically detected atrial fibrillation (AF) is associated with a significant increase in mortality and other adverse cardiovascular events. Since the advent of effective methods for AF rhythm control, investigators have attempted to determine ... Full text Open Access Link to item Cite

Variation in Health Status With Invasive vs Conservative Management of Chronic Coronary Disease.

Journal Article J Am Coll Cardiol · April 16, 2024 BACKGROUND: The ISCHEMIA trial found that patients with chronic coronary disease randomized to invasive strategy had better health status than those randomized to conservative strategy. It is unclear how best to translate these population-level results to ... Full text Link to item Cite

Regional differences in outcomes with ablation versus drug therapy for atrial fibrillation: Results from the CABANA trial.

Journal Article Am Heart J · April 2024 BACKGROUND: The finding of unexpected variations in treatment benefits by geographic region in international clinical trials raises complex questions about the interpretation and generalizability of trial findings. We observed such geographical variations ... Full text Open Access Link to item Cite

Incorporation of Drone Technology Into the Chain of Survival for OHCA: Estimation of Time Needed for Bystander Treatment of OHCA and CPR Performance.

Journal Article Circ Cardiovasc Qual Outcomes · April 2024 BACKGROUND: Drone-delivered automated external defibrillators (AEDs) hold promises in the treatment of out-of-hospital cardiac arrest. Our objective was to estimate the time needed to perform resuscitation with a drone-delivered AED and to measure cardiopu ... Full text Link to item Cite

Prognostic Impact of Repeated NT-proBNP Measurements in Patients With Heart Failure With Reduced Ejection Fraction.

Journal Article JACC Heart Fail · March 2024 BACKGROUND: Although clinical studies have demonstrated the association between a single N-terminal pro-B-type natriuretic peptide (NT-proBNP) measurement and clinical outcomes in chronic heart failure, the biomarker is frequently measured serially in clin ... Full text Link to item Cite

2022 ACC/AHA guideline for the diagnosis and management of aortic disease: A report of the American Heart Association/American College of Cardiology Joint Committee on Clinical Practice Guidelines.

Journal Article J Thorac Cardiovasc Surg · November 2023 AIM: The "2022 ACC/AHA Guideline for the Diagnosis and Management of Aortic Disease" provides recommendations to guide clinicians in the diagnosis, genetic evaluation and family screening, medical therapy, endovascular and surgical treatment, and long-term ... Full text Link to item Cite

Cost-Effectiveness of Vericiguat in Patients With Heart Failure With Reduced Ejection Fraction: The VICTORIA Randomized Clinical Trial.

Conference Circulation · October 3, 2023 BACKGROUND: The VICTORIA trial (Vericiguat Global Study in Subjects With Heart Failure With Reduced Ejection Fraction) demonstrated that, in patients with high-risk heart failure, vericiguat reduced the primary composite outcome of cardiovascular death or ... Full text Link to item Cite

Comparison of an Initial Risk-Based Testing Strategy vs Usual Testing in Stable Symptomatic Patients With Suspected Coronary Artery Disease: The PRECISE Randomized Clinical Trial.

Journal Article JAMA Cardiol · October 1, 2023 IMPORTANCE: Trials showing equivalent or better outcomes with initial evaluation using coronary computed tomography angiography (cCTA) compared with stress testing in patients with stable chest pain have informed guidelines but raise questions about overte ... Full text Link to item Cite

Deferred Testing in Stable Outpatients With Suspected Coronary Artery Disease: A Prespecified Secondary Analysis of the PRECISE Randomized Clinical Trial.

Journal Article JAMA Cardiol · October 1, 2023 IMPORTANCE: Guidelines recommend deferral of testing for symptomatic people with suspected coronary artery disease (CAD) and low pretest probability. To our knowledge, no randomized trial has prospectively evaluated such a strategy. OBJECTIVE: To assess pr ... Full text Link to item Cite

Impact of Complete Revascularization in the ISCHEMIA Trial.

Journal Article J Am Coll Cardiol · September 19, 2023 BACKGROUND: Anatomic complete revascularization (ACR) and functional complete revascularization (FCR) have been associated with reduced death and myocardial infarction (MI) in some prior studies. The impact of complete revascularization (CR) in patients un ... Full text Link to item Cite

2023 AHA/ACC/ACCP/ASPC/NLA/PCNA Guideline for the Management of Patients With Chronic Coronary Disease: A Report of the American Heart Association/American College of Cardiology Joint Committee on Clinical Practice Guidelines.

Journal Article Circulation · August 29, 2023 AIM: The "2023 AHA/ACC/ACCP/ASPC/NLA/PCNA Guideline for the Management of Patients With Chronic Coronary Disease" provides an update to and consolidates new evidence since the "2012 ACCF/AHA/ACP/AATS/PCNA/SCAI/STS Guideline for the Diagnosis and Management ... Full text Link to item Cite

Complete Revascularization and Angina-Related Health Status in the ISCHEMIA Trial.

Journal Article J Am Coll Cardiol · July 25, 2023 BACKGROUND: The impact of complete revascularization (CR) on angina-related health status (symptoms, function, quality of life) in chronic coronary disease (CCD) has not been well studied. OBJECTIVES: Among patients with CCD randomized to invasive (INV) vs ... Full text Link to item Cite

Clinical and cost implications of deferred testing in low-risk patients with stable chest pain: a simulation using the PROMISE trial.

Journal Article Am Heart J · July 2023 Current guidelines recommend a deferred testing approach in low-risk patients presenting with stable chest pain. After simulating a deferred testing approach using the PROMISE Minimal Risk Score to identify 915 minimal risk participants with cost data from ... Full text Link to item Cite

Health Status and Clinical Outcomes in Older Adults With Chronic Coronary Disease: The ISCHEMIA Trial.

Journal Article J Am Coll Cardiol · May 2, 2023 BACKGROUND: Whether initial invasive management in older vs younger adults with chronic coronary disease and moderate or severe ischemia improves health status or clinical outcomes is unknown. OBJECTIVES: The goal of this study was to examine the impact of ... Full text Link to item Cite

Effects of Ablation Versus Drug Therapy on Quality of Life by Sex in Atrial Fibrillation: Results From the CABANA Trial.

Journal Article J Am Heart Assoc · February 7, 2023 Background Women with atrial fibrillation (AF) demonstrate more AF-related symptoms and worse quality of life (QOL). Whether increased use of ablation in women reduces sex-related QOL differences is unknown. Sex-related outcomes for ablation versus drug th ... Full text Open Access Link to item Cite

Survival After Invasive or Conservative Management of Stable Coronary Disease.

Journal Article Circulation · January 3, 2023 BACKGROUND: The ISCHEMIA trial (International Study of Comparative Health Effectiveness With Medical and Invasive Approaches) compared an initial invasive versus an initial conservative management strategy for patients with chronic coronary disease and mod ... Full text Link to item Cite

Initial Thoracic Endovascular Aortic Repair vs Medical Therapy for Acute Uncomplicated Type B Aortic Dissection.

Journal Article JAMA Cardiol · January 1, 2023 IMPORTANCE: Thoracic endovascular aortic repair (TEVAR) has increasingly been used for uncomplicated type B aortic dissection (uTBAD) despite limited supporting data. OBJECTIVE: To assess whether initial TEVAR following uTBAD is associated with reduced mor ... Full text Link to item Cite

Opportunities and challenges to non-communicable disease (NCD) research and training in Pakistan: a qualitative study from Pakistan.

Journal Article BMJ Open · December 19, 2022 INTRODUCTION: Most of the global non-communicable disease (NCD)-related death burden is borne by low and middle-income countries (LMICs). In LMICs like Pakistan, however, a major gap in responding to NCDs is a lack of high-quality research leading to polic ... Full text Link to item Cite

Identifying quality of life outcome patterns to inform treatment choices in ischemic cardiomyopathy.

Journal Article Am Heart J · December 2022 BACKGROUND: The Surgical Treatment for Ischemic Heart Failure (STICH) trial found that routine use of coronary artery bypass surgery (CABG) improved mean quality of life (QoL) scores relative to guideline-directed medical therapy (GDMT) in patients with is ... Full text Link to item Cite

Influence of atrial fibrillation type on outcomes of ablation vs. drug therapy: results from CABANA.

Journal Article Europace · October 13, 2022 AIMS: Influence of atrial fibrillation (AF) type on outcomes seen with catheter ablation vs. drug therapy is incompletely understood. This study assesses the impact of AF type on treatment outcomes in the Catheter Ablation vs. Antiarrhythmic Drug Therapy f ... Full text Open Access Link to item Cite

The trial to assess chelation therapy 2 (TACT2): Rationale and design.

Journal Article Am Heart J · October 2022 BACKGROUND: Intravenous edetate disodium-based infusions reduced cardiovascular events in a prior clinical trial. The Trial to Assess Chelation Therapy 2 (TACT2) will replicate the initial study design. METHODS: TACT2 is an NIH-sponsored, randomized, 2x2 f ... Full text Link to item Cite

Patient-Reported Outcome Measures in Cardiovascular Disease: An Evidence Map of the Psychometric Properties of Health Status Instruments.

Journal Article Ann Intern Med · October 2022 BACKGROUND: Patient-reported outcomes (PROs) are important measures of treatment effect and can be used to inform the approval of cardiovascular drugs and devices by the U.S. Food and Drug Administration (FDA). PURPOSE: To catalogue the health status patie ... Full text Link to item Cite

Association of Medication Adherence With Health Outcomes in the ISCHEMIA Trial.

Journal Article J Am Coll Cardiol · August 23, 2022 BACKGROUND: The ISCHEMIA (International Study of Comparative Health Effectiveness With Medical and Invasive Approaches) trial randomized participants with chronic coronary disease (CCD) to guideline-directed medical therapy with or without angiography and ... Full text Link to item Cite

Cost-Effectiveness of Catheter Ablation Versus Antiarrhythmic Drug Therapy in Atrial Fibrillation: The CABANA Randomized Clinical Trial.

Journal Article Circulation · August 16, 2022 BACKGROUND: In the CABANA trial (Catheter Ablation vs Antiarrhythmic Drug Therapy for Atrial Fibrillation), catheter ablation did not significantly reduce the primary end point of death, disabling stroke, serious bleeding, or cardiac arrest compared with d ... Full text Link to item Cite

Physician judgement in predicting obstructive coronary artery disease and adverse events in chest pain patients.

Journal Article Heart · May 12, 2022 OBJECTIVE: To evaluate informal physician judgement versus pretest probability scores in estimating risk in patients with suspected coronary artery disease (CAD). METHODS: We included 4533 patients from the PROMISE (Prospective Multicenter Imaging Study fo ... Full text Link to item Cite

Presenting Symptoms in Patients Undergoing Coronary Artery Disease Evaluation: Association With Noninvasive Test Results and Clinical Outcomes in the PROMISE Trial.

Journal Article Circ Cardiovasc Qual Outcomes · May 2022 BACKGROUND: Patients evaluated for coronary artery disease have a range of symptoms and underlying risk. The relationships between patient-described symptoms, clinician conclusions, and subsequent clinical management and outcomes remain incompletely descri ... Full text Link to item Cite

2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure.

Journal Article J Card Fail · May 2022 AIM: The "2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure" replaces the "2013 ACCF/AHA Guideline for the Management of Heart Failure" and the "2017 ACC/AHA/HFSA Focused Update of the 2013 ACCF/AHA Guideline for the Management of Heart Failu ... Full text Link to item Cite

Comprehensive Quality-of-Life Outcomes With Invasive Versus Conservative Management of Chronic Coronary Disease in ISCHEMIA.

Journal Article Circulation · April 26, 2022 BACKGROUND: ISCHEMIA (International Study of Comparative Health Effectiveness with Medical and Invasive Approaches) compared an initial invasive treatment strategy (INV) with an initial conservative strategy in 5179 participants with chronic coronary disea ... Full text Link to item Cite

Association Between Age and Outcomes of Catheter Ablation Versus Medical Therapy for Atrial Fibrillation: Results From the CABANA Trial.

Journal Article Circulation · March 15, 2022 BACKGROUND: Observational data suggest that catheter ablation may be safe and effective to treat younger and older patients with atrial fibrillation. No large, randomized trial has examined this issue. This report describes outcomes according to age at ent ... Full text Open Access Link to item Cite

Cost-Effectiveness of Coronary Artery Bypass Surgery Versus Medicine in Ischemic Cardiomyopathy: The STICH Randomized Clinical Trial.

Journal Article Circulation · March 15, 2022 BACKGROUND: The STICH Randomized Clinical Trial (Surgical Treatment for Ischemic Heart Failure) demonstrated that coronary artery bypass grafting (CABG) reduced all-cause mortality rates out to 10 years compared with medical therapy alone (MED) in patients ... Full text Link to item Cite

Differences in Cardiovascular Risk, Coronary Artery Disease, and Cardiac Events Between Black and White Individuals Enrolled in the PROMISE Trial.

Journal Article JAMA Cardiol · March 1, 2022 IMPORTANCE: Race and ethnicity have been studied as risk factors in cardiovascular disease. How risk factors, epicardial coronary artery disease, and cardiac events differ between Black and White individuals undergoing noninvasive testing for coronary arte ... Full text Link to item Cite

The prospective randomized trial of the optimal evaluation of cardiac symptoms and revascularization: Rationale and design of the PRECISE trial.

Journal Article Am Heart J · March 2022 BACKGROUND: Clinicians vary widely in their preferred diagnostic approach to patients with non-acute chest pain. Such variation exposes patients to potentially avoidable risks, as well as inefficient care with increased costs and unresolved patient concern ... Full text Link to item Cite

Polypharmacy in Palliative Care for Advanced Heart Failure: The PAL-HF Experience.

Journal Article J Card Fail · February 2022 BACKGROUND: Palliative care (PC) in advanced heart failure (HF) aims to improve symptoms and quality of life (QOL), in part through medication management. The impact of PC on polypharmacy (>5 medications) remains unknown. METHODS AND RESULTS: We explored p ... Full text Link to item Cite

The influence of comorbidities on achieving an N-terminal pro-b-type natriuretic peptide target: a secondary analysis of the GUIDE-IT trial.

Journal Article ESC Heart Fail · February 2022 AIMS: N-terminal pro-b-type natriuretic peptide (NT-proBNP) values may be influenced by patient factors beyond the severity of illness, including atrial fibrillation (AF), renal dysfunction, or increased body mass index (BMI). We hypothesized that these fa ... Full text Link to item Cite

Association between economic and arrhythmic burden of paroxysmal atrial fibrillation in patients with cardiac implanted electronic devices.

Journal Article Am Heart J · February 2022 BACKGROUND: As the prevalence of atrial fibrillation (AF) increases, a greater understanding of the costs associated with AF care is required. While individuals with greater arrhythmic burden may interact with the health system more frequently, the relatio ... Full text Link to item Cite

Race Differences in Quality of Life following a Palliative Care Intervention in Patients with Advanced Heart Failure: Insights from the Palliative Care in Heart Failure Trial.

Journal Article J Palliat Med · February 2022 Introduction: Black patients have a higher incidence of heart failure (HF) and worse outcomes than white patients. Guidelines recommend palliative care for patients with advanced HF, but no studies have examined outcomes in a black patient cohort. Methods: ... Full text Link to item Cite

Bimodal distribution of atrial fibrillation burden in 3 distinct cohorts: What is 'paroxysmal' atrial fibrillation?

Journal Article Am Heart J · February 2022 BACKGROUND: Burden of atrial fibrillation (AF), as a continuous measure, is an emerging alternative classification often assumed to increase linearly with progression of disease. Yet there are no descriptions of AF burden distributions across populations. ... Full text Link to item Cite

Arrhythmic Burden and the Risk of Cardiovascular Outcomes in Patients With Paroxysmal Atrial Fibrillation and Cardiac Implanted Electronic Devices.

Journal Article Circ Arrhythm Electrophysiol · February 2022 BACKGROUND: Whether the amount of atrial fibrillation (AF) patients experience conveys important prognostic information beyond that provided by the diagnosis of AF is uncertain. The study objective was to assess the dose-response relationship between devic ... Full text Link to item Cite

Diagnosis-to-ablation time predicts recurrent atrial fibrillation and rehospitalization following catheter ablation.

Journal Article Heart Rhythm O2 · February 2022 BACKGROUND: Wait times for catheter ablation in patients with symptomatic atrial fibrillation (AF) may influence clinical outcomes. OBJECTIVE: This study examined the relationship between the duration from AF diagnosis to ablation, or diagnosis-to-ablation ... Full text Open Access Link to item Cite

Effects of initial invasive vs. initial conservative treatment strategies on recurrent and total cardiovascular events in the ISCHEMIA trial.

Journal Article Eur Heart J · January 13, 2022 AIMS: The International Study of Comparative Health Effectiveness with Medical and Invasive Approaches (ISCHEMIA) trial prespecified an analysis to determine whether accounting for recurrent cardiovascular events in addition to first events modified unders ... Full text Link to item Cite

Factors and outcomes associated with improved left ventricular systolic function in patients with cardiomyopathy.

Journal Article Cardiol J · 2022 BACKGROUND: Many patients in the Sudden Cardiac Death in Heart Failure Trial (SCD-HeFT) had a significant improvement (> 10%) in the left ventricular ejection fraction (LVEF) during the course of the study, but the factors and outcomes associated with such ... Full text Link to item Cite

Assessing race and ethnicity differences in outcomes based on GDMT and target NT-proBNP in patients with heart failure with reduced ejection fraction: An analysis of the GUIDE-IT study.

Journal Article Prog Cardiovasc Dis · 2022 BACKGROUND: The GUIDE-IT trial was, a multicenter, randomized, parallel group, unblinded study that randomized patients to having heart failure therapy titrated to achieve an NT-proBNP <1000 pg/mL or to usual clinical care. METHODS AND RESULTS: We performe ... Full text Link to item Cite

Outcomes for patients with anterior myocardial infarction and prior cardiac arrest in the home automated external defibrillator trial (HAT).

Journal Article Resuscitation · November 2021 BACKGROUND: Patients with sudden cardiac arrest occurring in the acute phase of myocardial infarction (MI-SCA) are believed to be at similar risk of death after revascularization compared with MI patients without SCA (MI-no SCA). Among patients with anteri ... Full text Link to item Cite

Outcomes in the ISCHEMIA Trial Based on Coronary Artery Disease and Ischemia Severity.

Journal Article Circulation · September 28, 2021 BACKGROUND: The ISCHEMIA trial (International Study of Comparative Health Effectiveness With Medical and Invasive Approaches) postulated that patients with stable coronary artery disease (CAD) and moderate or severe ischemia would benefit from revasculariz ... Full text Link to item Cite

Ablation Versus Drug Therapy for Atrial Fibrillation in Racial and Ethnic Minorities.

Journal Article J Am Coll Cardiol · July 13, 2021 BACKGROUND: Rhythm control strategies for atrial fibrillation (AF), including catheter ablation, are substantially underused in racial/ethnic minorities in North America. OBJECTIVES: This study sought to describe outcomes in the CABANA trial as a function ... Full text Open Access Link to item Cite

The Cost-Effectiveness of Palliative Care: Insights from the PAL-HF Trial.

Journal Article J Card Fail · June 2021 BACKGROUND: In a randomized control trial, Palliative Care in Heart Failure (PAL-HF) improved heart failure-related quality of life, though cost-effectiveness remains unknown. The aim of this study was to evaluate the cost-effectiveness of the PAL-HF trial ... Full text Link to item Cite

Atrial fibrillation burden and heart failure: Data from 39,710 individuals with cardiac implanted electronic devices.

Journal Article Heart Rhythm · May 2021 BACKGROUND: Atrial fibrillation (AF) and heart failure (HF) often accompany one another, and each is independently associated with poor outcomes. However, the association between AF burden and outcomes is poorly understood. OBJECTIVE: The purpose of this s ... Full text Link to item Cite

Ablation Versus Drug Therapy for Atrial Fibrillation in Heart Failure: Results From the CABANA Trial.

Journal Article Circulation · April 6, 2021 BACKGROUND: In patients with heart failure and atrial fibrillation (AF), several clinical trials have reported improved outcomes, including freedom from AF recurrence, quality of life, and survival, with catheter ablation. This article describes the treatm ... Full text Open Access Link to item Cite

Association Between Sex and Treatment Outcomes of Atrial Fibrillation Ablation Versus Drug Therapy: Results From the CABANA Trial.

Journal Article Circulation · February 16, 2021 BACKGROUND: Among patients with atrial fibrillation (AF), women are less likely to receive catheter ablation and may have more complications and less durable results. Most information about sex-specific differences after ablation comes from observational d ... Full text Open Access Link to item Cite

2020 ACC/AHA Guideline for the Management of Patients With Valvular Heart Disease: Executive Summary: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines.

Journal Article Circulation · February 2, 2021 AIM: This executive summary of the valvular heart disease guideline provides recommendations for clinicians to diagnose and manage valvular heart disease as well as supporting documentation to encourage their use. METHODS: A comprehensive literature search ... Full text Link to item Cite

Disparities in Cardiovascular Research Output and Disease Outcomes among High-, Middle- and Low-Income Countries - An Analysis of Global Cardiovascular Publications over the Last Decade (2008-2017).

Journal Article Glob Heart · January 18, 2021 BACKGROUND: Cardiovascular disease (CVD) is the leading cause of death and disability worldwide. Health research is crucial to managing disease burden. Previous work has highlighted marked discrepancies in research output and disease burden between high-in ... Full text Link to item Cite

Economic Evaluation of Catheter Ablation of Atrial Fibrillation in Patients with Heart Failure With Reduced Ejection Fraction.

Journal Article Circ Cardiovasc Qual Outcomes · December 2020 BACKGROUND: Randomized clinical trials have demonstrated that catheter ablation for atrial fibrillation in patients with heart failure with reduced ejection fraction may improve survival and other cardiovascular outcomes. METHODS: We constructed a decision ... Full text Link to item Cite

Cost-effectiveness Analysis of Anatomic vs Functional Index Testing in Patients With Low-Risk Stable Chest Pain.

Journal Article JAMA Netw Open · December 1, 2020 IMPORTANCE: Both noninvasive anatomic and functional testing strategies are now routinely used as initial workup in patients with low-risk stable chest pain (SCP). OBJECTIVE: To determine whether anatomic approaches (ie, coronary computed tomography angiog ... Full text Link to item Cite

Differential Outcomes With Edetate Disodium-Based Treatment Among Stable Post Anterior vs. Non-Anterior Myocardial Infarction Patients.

Journal Article Cardiovasc Revasc Med · November 2020 BACKGROUND: The Trial to Assess Chelation Therapy (TACT) found that chelation therapy significantly reduced clinical events in patients with a history of myocardial infarction (MI). The initial report of TACT included the observation of an interaction betw ... Full text Link to item Cite

Possible differential benefits of edetate disodium in post-myocardial infarction patients with diabetes treated with different hypoglycemic strategies in the Trial to Assess Chelation Therapy (TACT).

Journal Article J Diabetes Complications · August 2020 BACKGROUND: The NIH-funded Trial to Assess Chelation Therapy (TACT) randomized 1708 stable patients age ≥50 who were ≥6 months post myocardial infarction to 40 infusions of an edetate disodium-based regimen or placebo. In 633 patients with diabetes, edetat ... Full text Link to item Cite

Long-Term Outcomes of Implantable Cardioverter-Defibrillator Therapy in the SCD-HeFT.

Journal Article J Am Coll Cardiol · July 28, 2020 BACKGROUND: The SCD-HeFT (Sudden Cardiac Death in Heart Failure Trial) randomized 2,521 patients with moderate heart failure (HF) to amiodarone, placebo drug, or implantable cardioverter-defibrillator (ICD) therapy. Original trial follow-up ended October 3 ... Full text Link to item Cite

Assessment of Limitations to Optimization of Guideline-Directed Medical Therapy in Heart Failure From the GUIDE-IT Trial: A Secondary Analysis of a Randomized Clinical Trial.

Journal Article JAMA Cardiol · July 1, 2020 IMPORTANCE: Despite evidence that guideline-directed medical therapy (GDMT) improves outcomes in patients with heart failure (HF) and reduced ejection fraction, many patients are undertreated. The Guiding Evidence-Based Therapy Using Biomarker Intensified ... Full text Link to item Cite

Cost-Effectiveness of Extended Electrocardiogram Monitoring for Atrial Fibrillation After Stroke: A Systematic Review.

Journal Article Stroke · July 2020 BACKGROUND AND PURPOSE: Management of cryptogenic stroke involves the identification of modifiable risk factors, such as atrial fibrillation (AF). Extended rhythm monitoring increases AF detection rates but at an increased device cost compared with convent ... Full text Link to item Cite

Recurrence of Atrial Fibrillation After Catheter Ablation or Antiarrhythmic Drug Therapy in the CABANA Trial.

Journal Article J Am Coll Cardiol · June 30, 2020 BACKGROUND: The CABANA (Catheter Ablation Versus Antiarrhythmic Drug Therapy for Atrial Fibrillation) trial randomized 2,204 patients with atrial fibrillation (AF) to catheter ablation or drug therapy. Analysis by intention-to-treat showed a nonsignificant ... Full text Open Access Link to item Cite

Levosimendan in patients with reduced left ventricular function undergoing isolated coronary or valve surgery.

Journal Article J Thorac Cardiovasc Surg · June 2020 OBJECTIVE: In the Levosimendan in Patients with Left Ventricular Systolic Dysfunction Undergoing Cardiac Surgery Requiring Cardiopulmonary Bypass (LEVO-CTS) trial, no differences in clinical outcomes were observed between levosimendan and placebo in a broa ... Full text Link to item Cite

Management of Coronary Disease in Patients with Advanced Kidney Disease.

Journal Article N Engl J Med · April 23, 2020 BACKGROUND: Clinical trials that have assessed the effect of revascularization in patients with stable coronary disease have routinely excluded those with advanced chronic kidney disease. METHODS: We randomly assigned 777 patients with advanced kidney dise ... Full text Link to item Cite

Health Status after Invasive or Conservative Care in Coronary and Advanced Kidney Disease.

Journal Article N Engl J Med · April 23, 2020 BACKGROUND: In the ISCHEMIA-CKD trial, the primary analysis showed no significant difference in the risk of death or myocardial infarction with initial angiography and revascularization plus guideline-based medical therapy (invasive strategy) as compared w ... Full text Link to item Cite

Health-Status Outcomes with Invasive or Conservative Care in Coronary Disease.

Journal Article N Engl J Med · April 9, 2020 BACKGROUND: In the ISCHEMIA trial, an invasive strategy with angiographic assessment and revascularization did not reduce clinical events among patients with stable ischemic heart disease and moderate or severe ischemia. A secondary objective of the trial ... Full text Link to item Cite

Initial Invasive or Conservative Strategy for Stable Coronary Disease.

Journal Article N Engl J Med · April 9, 2020 BACKGROUND: Among patients with stable coronary disease and moderate or severe ischemia, whether clinical outcomes are better in those who receive an invasive intervention plus medical therapy than in those who receive medical therapy alone is uncertain. M ... Full text Link to item Cite

Implications of Abnormal Exercise Electrocardiography With Normal Stress Echocardiography.

Journal Article JAMA Intern Med · April 1, 2020 IMPORTANCE: Patients with abnormal (positive) exercise electrocardiography, but normal stress echocardiography (+ECG/-Echo) are commonly encountered in clinical practice; however, the prognostic significance of this discordant result is unclear. OBJECTIVE: ... Full text Link to item Cite

Diagnosis-to-Ablation Time and Recurrence of Atrial Fibrillation Following Catheter Ablation: A Systematic Review and Meta-Analysis of Observational Studies.

Journal Article Circ Arrhythm Electrophysiol · April 2020 BACKGROUND: The optimal timing of catheter ablation for atrial fibrillation (AF) in reference to the time of diagnosis is unknown. We sought to assess the impact of the duration between first diagnosis of AF and ablation, or diagnosis-to-ablation time (DAT ... Full text Link to item Cite

Clinical and Economic Implications of Inconclusive Noninvasive Test Results in Stable Patients With Suspected Coronary Artery Disease: Insights From the PROMISE Trial.

Journal Article Circ Cardiovasc Imaging · April 2020 BACKGROUND: Inconclusive noninvasive tests complicate the care of patients with suspected coronary artery disease, but their prevalence and impact on management, outcomes, and costs are not well described. METHODS: PROMISE (Prospective Multicenter Imaging ... Full text Link to item Cite

Discordances between predicted and actual risk in obese patients with suspected cardiac ischaemia.

Journal Article Heart · February 2020 OBJECTIVES: To test the relationship between increasing severity of obesity, calculated risk and observed outcomes. METHODS: Patients with symptoms suggestive of coronary artery disease (CAD) (n=10 003) were stratified according to body mass index (BMI). W ... Full text Link to item Cite

ISCHEMIA trial update.

Journal Article Am Heart J · December 2019 Full text Link to item Cite

Natriuretic Peptide Response and Outcomes in Chronic Heart Failure With Reduced Ejection Fraction.

Journal Article J Am Coll Cardiol · September 3, 2019 BACKGROUND: The GUIDE-IT (GUIDing Evidence Based Therapy Using Biomarker Intensified Treatment in Heart Failure) trial demonstrated that a strategy to "guide" application of guideline-directed medical therapy (GDMT) by reducing amino-terminal pro-B-type na ... Full text Link to item Cite

Myocardial Viability and Long-Term Outcomes in Ischemic Cardiomyopathy.

Journal Article N Engl J Med · August 22, 2019 BACKGROUND: The role of assessment of myocardial viability in identifying patients with ischemic cardiomyopathy who might benefit from surgical revascularization remains controversial. Furthermore, although improvement in left ventricular function is one o ... Full text Link to item Cite

The effect of EDTA-based chelation on patients with diabetes and peripheral artery disease in the Trial to Assess Chelation Therapy (TACT).

Journal Article J Diabetes Complications · July 2019 OBJECTIVE: Approximately 1 in 7 US adults have diabetes; and over 60% of deaths in patients with diabetes have cardiac disease as a principal or contributing cause. Both coronary and peripheral artery disease (PAD) identify high-risk cohorts among patients ... Full text Link to item Cite

Clinical factors related to morbidity and mortality in high-risk heart failure patients: the GUIDE-IT predictive model and risk score.

Journal Article Eur J Heart Fail · June 2019 BACKGROUND: Most heart failure (HF) risk scores have been derived from cohorts of stable HF patients and may not incorporate up to date treatment regimens or deep phenotype characterization that change baseline risk over the short- and long-term follow-up ... Full text Link to item Cite

Relationship Between Optimism and Outcomes in Patients With Chronic Angina Pectoris.

Journal Article Am J Cardiol · May 1, 2019 Greater optimism regarding recovery from chronic illness is associated with improved quality of life and clinical outcomes. We performed a post-hoc analysis on the association between optimism and outcomes in Ranolazine in Patients with Incomplete Revascul ... Full text Link to item Cite

Patient-Reported Outcomes in Atrial Fibrillation Research: Results of a Clinicaltrials.gov Analysis.

Journal Article JACC Clin Electrophysiol · May 2019 OBJECTIVES: This study sought to determine how frequently patient-reported outcomes (PROs) are collected in registered clinical studies of atrial fibrillation (AF). BACKGROUND: Improving symptom burden and quality of life are important goals in the treatme ... Full text Link to item Cite

Acute and 1-Year Hospitalization Costs for Acute Myocardial Infarction Treated With Percutaneous Coronary Intervention: Results From the TRANSLATE-ACS Registry.

Journal Article J Am Heart Assoc · April 16, 2019 Background Hospitalization for acute myocardial infarction (MI) in the United States is both common and expensive, but those features alone provide little insight into cost-saving opportunities. Methods and Results To understand the cost drivers during hos ... Full text Link to item Cite

Effect of Catheter Ablation vs Medical Therapy on Quality of Life Among Patients With Atrial Fibrillation: The CABANA Randomized Clinical Trial.

Journal Article JAMA · April 2, 2019 IMPORTANCE: Catheter ablation is more effective than drug therapy in restoring sinus rhythm in patients with atrial fibrillation (AF), but its incremental effect on long-term quality of life (QOL) is uncertain. OBJECTIVE: To determine whether catheter abla ... Full text Link to item Cite

Effect of Catheter Ablation vs Antiarrhythmic Drug Therapy on Mortality, Stroke, Bleeding, and Cardiac Arrest Among Patients With Atrial Fibrillation: The CABANA Randomized Clinical Trial.

Journal Article JAMA · April 2, 2019 IMPORTANCE: Catheter ablation is effective in restoring sinus rhythm in atrial fibrillation (AF), but its effects on long-term mortality and stroke risk are uncertain. OBJECTIVE: To determine whether catheter ablation is more effective than conventional me ... Full text Open Access Link to item Cite

Stress Testing Versus CT Angiography in Patients With Diabetes and Suspected Coronary Artery Disease.

Journal Article J Am Coll Cardiol · March 5, 2019 BACKGROUND: The optimal noninvasive test (NIT) for patients with diabetes and stable symptoms of coronary artery disease (CAD) is unknown. OBJECTIVES: The purpose of this study was to assess whether a diagnostic strategy based on coronary computed tomograp ... Full text Link to item Cite

Baseline Characteristics and Risk Profiles of Participants in the ISCHEMIA Randomized Clinical Trial.

Journal Article JAMA Cardiol · March 1, 2019 IMPORTANCE: It is unknown whether coronary revascularization, when added to optimal medical therapy, improves prognosis in patients with stable ischemic heart disease (SIHD) at increased risk of cardiovascular events owing to moderate or severe ischemia. O ... Full text Link to item Cite

Design Considerations for UAV-Delivered Opioid Overdose Interventions

Conference IEEE Aerospace Conference Proceedings · March 1, 2019 With recent regulatory changes that allow for commercial unmanned aerial vehicle (UAV)operations, there has been increasing interest in using UAVs, aka drones, for delivery of medical care, especially in rural areas. Previous work has focused on Automated ... Full text Cite

Sex differences in management and outcomes of patients with stable symptoms suggestive of coronary artery disease: Insights from the PROMISE trial.

Journal Article Am Heart J · February 2019 BACKGROUND: Although sex differences exist in the management of acute coronary syndromes, less is known about the management and outcomes of women and men with suspected coronary artery disease being evaluated with noninvasive testing (NIT). METHODS: We in ... Full text Link to item Cite

NT-proBNP Goal Achievement Is Associated With Significant Reverse Remodeling and Improved Clinical Outcomes in HFrEF.

Journal Article JACC Heart Fail · February 2019 OBJECTIVES: This study aims to assess the association between biomarker-guided therapy and left ventricular (LV) remodeling. BACKGROUND: In patients with heart failure with reduced ejection fraction (HFrEF), it is unclear if lowering natriuretic peptides r ... Full text Link to item Cite

Predictive Model for High-Risk Coronary Artery Disease.

Journal Article Circ Cardiovasc Imaging · February 2019 BACKGROUND: Patients with high-risk coronary artery disease (CAD) may be difficult to identify. METHODS: Using the PROMISE (Prospective Multicenter Imaging Study for Evaluation of Chest Pain) cohort randomized to coronary computed tomographic angiography ( ... Full text Link to item Cite

Effects of obesity on noninvasive test results in patients with suspected cardiac ischemia: Insights from the PROMISE trial.

Journal Article J Cardiovasc Comput Tomogr · 2019 BACKGROUND: Obesity is a risk factor for coronary artery disease (CAD), but adiposity may mimic symptoms of CAD and reduce the accuracy of diagnostic testing. METHODS: Patients from the PROMISE trial (n = 8889) were classified according to body mass index ... Full text Link to item Cite

Economic and Quality-of-Life Outcomes of Natriuretic Peptide-Guided Therapy for Heart Failure.

Journal Article J Am Coll Cardiol · November 27, 2018 BACKGROUND: The GUIDE-IT (GUIDing Evidence Based Therapy Using Biomarker Intensified Treatment in Heart Failure) trial prospectively compared the efficacy of an N-terminal pro-B-type natriuretic peptide (NT-proBNP)-guided heart failure treatment strategy ( ... Full text Link to item Cite

International Study of Comparative Health Effectiveness with Medical and Invasive Approaches-Chronic Kidney Disease (ISCHEMIA-CKD): Rationale and design.

Journal Article Am Heart J · November 2018 BACKGROUND: Patients with chronic kidney disease (CKD) and stable ischemic heart disease are at markedly increased risk of cardiovascular events. Prior trials comparing a strategy of optimal medical therapy (OMT) with or without revascularization have larg ... Full text Link to item Cite

Long-term outcomes of mitral regurgitation by type and severity.

Journal Article Am Heart J · September 2018 BACKGROUND: We aimed to determine the association of MR severity and type with all-cause death in a large, real-world, clinical setting. METHODS: We reviewed full echocardiography studies at Duke Echocardiography Laboratory (01/01/1995-12/31/2010), classif ... Full text Link to item Cite

Improving the Use of Primary Prevention Implantable Cardioverter-Defibrillators Therapy With Validated Patient-Centric Risk Estimates.

Journal Article JACC Clin Electrophysiol · August 2018 OBJECTIVES: The authors previously developed the Seattle Proportional Risk Model (SPRM) in systolic heart failure patients without implantable cardioverter-defibrillators (ICDs)to predict the proportion of deaths that were sudden. They subsequently validat ... Full text Link to item Cite

Revascularization in stable coronary disease: evidence and uncertainties.

Journal Article Nat Rev Cardiol · July 2018 Although revascularization has been one of the primary treatment options for obstructive coronary artery disease (CAD) for about 50 years, the evidence base for its use is most robust in the area of acute coronary disease. By contrast, evidence - particula ... Full text Link to item Cite

International Study of Comparative Health Effectiveness with Medical and Invasive Approaches (ISCHEMIA) trial: Rationale and design.

Journal Article Am Heart J · July 2018 BACKGROUND: Prior trials comparing a strategy of optimal medical therapy with or without revascularization have not shown that revascularization reduces cardiovascular events in patients with stable ischemic heart disease (SIHD). However, those trials only ... Full text Link to item Cite

In Response.

Journal Article Anesth Analg · July 2018 Full text Link to item Cite

Implantable cardioverter-defibrillators in heart failure patients with reduced ejection fraction and diabetes.

Journal Article Eur J Heart Fail · June 2018 AIM: There is limited information on the outcomes after primary prevention implantable cardioverter-defibrillator (ICD) implantation in patients with heart failure (HF) and diabetes. This analysis evaluates the effectiveness of a strategy of ICD plus medic ... Full text Link to item Cite

Catheter Ablation versus Antiarrhythmic Drug Therapy for Atrial Fibrillation (CABANA) Trial: Study Rationale and Design.

Journal Article Am Heart J · May 2018 The Catheter Ablation Versus Anti-arrhythmic Drug Therapy for Atrial Fibrillation (CABANA,NCT00911508)(1) trial is testing the hypothesis that the treatment strategy of percutaneous left atrial catheter ablation for the purpose of eliminating atrial fibril ... Full text Link to item Cite

The External Validity of Prediction Models for the Diagnosis of Obstructive Coronary Artery Disease in Patients With Stable Chest Pain: Insights From the PROMISE Trial.

Journal Article JACC Cardiovasc Imaging · March 2018 OBJECTIVES: This study sought to externally validate prediction models for the presence of obstructive coronary artery disease (CAD). BACKGROUND: A better assessment of the probability of CAD may improve the identification of patients who benefit from noni ... Full text Link to item Cite

Quality of life in patients with implantable cardioverter-defibrillator: systematic review of randomized controlled trials.

Journal Article Eur J Cardiovasc Nurs · March 2018 BACKGROUND: Implantable cardioverter-defibrillator (ICD) therapy significantly improves the survival of patients who are at high risk for sudden cardiac death. However, it is unclear whether this survival is accompanied by impairment on quality of life (Qo ... Full text Link to item Cite

Use of High-Risk Coronary Atherosclerotic Plaque Detection for Risk Stratification of Patients With Stable Chest Pain: A Secondary Analysis of the PROMISE Randomized Clinical Trial.

Journal Article JAMA Cardiol · February 1, 2018 IMPORTANCE: Coronary computed tomographic angiography (coronary CTA) can characterize coronary artery disease, including high-risk plaque. A noninvasive method of identifying high-risk plaque before major adverse cardiovascular events (MACE) could provide ... Full text Link to item Cite

Effect of high-dose oral multivitamins and minerals in participants not treated with statins in the randomized Trial to Assess Chelation Therapy (TACT).

Journal Article Am Heart J · January 2018 IMPORTANCE: In a prespecified subgroup analysis of participants not on statin therapy at baseline in the TACT, a high-dose complex oral multivitamins and multimineral regimen was found to have a large unexpected benefit compared with placebo. The regimen t ... Full text Link to item Cite

Six-minute walk distance after coronary artery bypass grafting compared with medical therapy in ischaemic cardiomyopathy.

Journal Article Open Heart · 2018 BACKGROUND: In patients with ischaemic left ventricular dysfunction, coronary artery bypass surgery (CABG) may decrease mortality, but it is not known whether CABG improves functional capacity. OBJECTIVE: To determine whether CABG compared with medical the ... Full text Open Access Link to item Cite

Comparison of Incidence of Left Ventricular Systolic Dysfunction Among Patients With Left Bundle Branch Block Versus Those With Normal QRS Duration.

Journal Article Am J Cardiol · December 1, 2017 We compared the incidence of left ventricular systolic dysfunction (LVSD) among patients with left bundle branch block (LBBB) to a matched cohort of patients with a narrow QRS duration <120 ms (NQRS). We hypothesized patients with preserved ejection fracti ... Full text Link to item Cite

Noninvasive FFR Derived From Coronary CT Angiography: Management and Outcomes in the PROMISE Trial.

Journal Article JACC Cardiovasc Imaging · November 2017 OBJECTIVES: The purpose of this study was to determine whether noninvasive fractional flow reserve derived from computed tomography (FFRCT) predicts coronary revascularization and outcomes and whether its addition improves efficiency of referral to invasiv ... Full text Link to item Cite

Predicting appropriate shocks in patients with heart failure: Patient level meta-analysis from SCD-HeFT and MADIT II.

Conference J Cardiovasc Electrophysiol · November 2017 BACKGROUND: No precise tools exist to predict appropriate shocks in patients with a primary prevention ICD. We sought to identify characteristics predictive of appropriate shocks in patients with a primary prevention implantable cardioverter defibrillator ... Full text Link to item Cite

Impact of Diabetes Mellitus on the Evaluation of Stable Chest Pain Patients: Insights From the PROMISE (Prospective Multicenter Imaging Study for Evaluation of Chest Pain) Trial.

Journal Article J Am Heart Assoc · October 31, 2017 BACKGROUND: The impact of diabetes mellitus on the clinical presentation and noninvasive test (NIT) results among stable outpatients presenting with symptoms suggestive of coronary artery disease (CAD) has not been well described. METHODS AND RESULTS: The ... Full text Link to item Cite

Quantifying sociodemographic and income disparities in medical therapy and lifestyle among symptomatic patients with suspected coronary artery disease: a cross-sectional study in North America.

Journal Article BMJ Open · September 29, 2017 OBJECTIVES: To evaluate potential gaps in preventive medical therapy and healthy lifestyle practices among symptomatic patients with suspected coronary artery disease (CAD) seeing primary care physicians and cardiologists and how gaps vary by sociodemograp ... Full text Link to item Cite

New York Heart Association class and the survival benefit from primary prevention implantable cardioverter defibrillators: A pooled analysis of 4 randomized controlled trials.

Conference Am Heart J · September 2017 BACKGROUND: Primary prevention implantable cardioverter defibrillator (ICD) reduce all-cause mortality by reducing sudden cardiac death. There are conflicting data regarding whether patients with more advanced heart failure derive ICD benefit owing to the ... Full text Link to item Cite

The Metabolic Syndrome and Risk of Sudden Cardiac Death: The Atherosclerosis Risk in Communities Study.

Journal Article J Am Heart Assoc · August 23, 2017 BACKGROUND: Prior studies have demonstrated a link between the metabolic syndrome and increased risk of cardiovascular mortality. Whether the metabolic syndrome is associated with sudden cardiac death is uncertain. METHODS AND RESULTS: We characterized the ... Full text Link to item Cite

Effect of Natriuretic Peptide-Guided Therapy on Hospitalization or Cardiovascular Mortality in High-Risk Patients With Heart Failure and Reduced Ejection Fraction: A Randomized Clinical Trial.

Journal Article JAMA · August 22, 2017 IMPORTANCE: The natriuretic peptides are biochemical markers of heart failure (HF) severity and predictors of adverse outcomes. Smaller studies have evaluated adjusting HF therapy based on natriuretic peptide levels ("guided therapy") with inconsistent res ... Full text Link to item Cite

Palliative Care in Heart Failure: The PAL-HF Randomized, Controlled Clinical Trial.

Journal Article J Am Coll Cardiol · July 18, 2017 BACKGROUND: Advanced heart failure (HF) is characterized by high morbidity and mortality. Conventional therapy may not sufficiently reduce patient suffering and maximize quality of life. OBJECTIVES: The authors investigated whether an interdisciplinary pal ... Full text Link to item Cite

Accuracy of Medical Claims for Identifying Cardiovascular and Bleeding Events After Myocardial Infarction : A Secondary Analysis of the TRANSLATE-ACS Study.

Journal Article JAMA Cardiol · July 1, 2017 IMPORTANCE: Pragmatic clinical trial designs have proposed the use of medical claims data to ascertain clinical events; however, the accuracy of billed diagnoses in identifying potential events is unclear. OBJECTIVES: To compare the 1-year cumulative incid ... Full text Link to item Cite

Prognostic Value of Noninvasive Cardiovascular Testing in Patients With Stable Chest Pain: Insights From the PROMISE Trial (Prospective Multicenter Imaging Study for Evaluation of Chest Pain).

Journal Article Circulation · June 13, 2017 BACKGROUND: Optimal management of patients with stable chest pain relies on the prognostic information provided by noninvasive cardiovascular testing, but there are limited data from randomized trials comparing anatomic with functional testing. METHODS: In ... Full text Link to item Cite

Primary Prevention Implantable Cardioverter Defibrillators in Patients With Nonischemic Cardiomyopathy: A Meta-analysis.

Journal Article JAMA Cardiol · June 1, 2017 IMPORTANCE: Conflicting data have emerged on the efficacy of implantable cardioverter defibrillators (ICDs) for primary prevention of sudden cardiac death (primary prevention ICDs) in patients with nonischemic cardiomyopathy. OBJECTIVE: To investigate the ... Full text Link to item Cite

Ranolazine After Incomplete Percutaneous Coronary Revascularization in Patients With Versus Without Diabetes Mellitus: RIVER-PCI Trial.

Journal Article J Am Coll Cardiol · May 9, 2017 BACKGROUND: Chronic angina is more common in patients with diabetes mellitus (DM) with poor glucose control. Ranolazine both treats chronic angina and improves glucose control. OBJECTIVES: This study sought to examine ranolazine's antianginal effect in rel ... Full text Link to item Cite

Economic Analysis of Apixaban Therapy for Patients With Atrial Fibrillation From a US Perspective: Results From the ARISTOTLE Randomized Clinical Trial.

Journal Article JAMA Cardiol · May 1, 2017 IMPORTANCE: The Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation (ARISTOTLE) trial reported that apixaban therapy was superior to warfarin therapy in preventing stroke and all-cause death while causing significantly f ... Full text Link to item Cite

Impact of Ezetimibe on the Rate of Cardiovascular-Related Hospitalizations and Associated Costs Among Patients With a Recent Acute Coronary Syndrome: Results From the IMPROVE-IT Trial (Improved Reduction of Outcomes: Vytorin Efficacy International Trial).

Journal Article Circ Cardiovasc Qual Outcomes · May 2017 BACKGROUND: Ezetimibe, when added to simvastatin therapy, reduces cardiovascular events after recent acute coronary syndrome. However, the impact of ezetimibe on cardiovascular-related hospitalizations and associated costs is unknown. METHODS AND RESULTS: ... Full text Link to item Cite

Identification of Patients With Stable Chest Pain Deriving Minimal Value From Noninvasive Testing: The PROMISE Minimal-Risk Tool, A Secondary Analysis of a Randomized Clinical Trial.

Journal Article JAMA Cardiol · April 1, 2017 IMPORTANCE: Guidelines recommend noninvasive testing for patients with stable chest pain, although many subsequently have normal test results and no adverse clinical events. OBJECTIVE: To describe a risk tool developed to use only pretest clinical data to ... Full text Link to item Cite

Comparison of visual assessment of coronary stenosis with independent quantitative coronary angiography: Findings from the Prospective Multicenter Imaging Study for Evaluation of Chest Pain (PROMISE) trial.

Journal Article Am Heart J · February 2017 BACKGROUND: The outcomes in patients by visual assessment and quantitative coronary angiography (QCA) for obstructive coronary artery disease (CAD) are not known. Our objectives were to compare visual and QCA estimates of obstructive CAD and to assess thei ... Full text Link to item Cite

Safety of coronary CT angiography and functional testing for stable chest pain in the PROMISE trial: A randomized comparison of test complications, incidental findings, and radiation dose.

Journal Article J Cardiovasc Comput Tomogr · 2017 BACKGROUND: Coronary computed tomography angiography (CTA) and functional testing strategies for stable chest pain yield similar outcomes; one aspect that may guide test choice is safety. METHODS: We compared test safety (test complications, incidental fin ... Full text Open Access Link to item Cite

Understanding the Role of P Values and Hypothesis Tests in Clinical Research.

Journal Article JAMA Cardiol · December 1, 2016 P values and hypothesis testing methods are frequently misused in clinical research. Much of this misuse appears to be owing to the widespread, mistaken belief that they provide simple, reliable, and objective triage tools for separating the true and impor ... Full text Link to item Cite

Changes in Medical Therapy and Lifestyle After Anatomical or Functional Testing for Coronary Artery Disease.

Journal Article J Am Heart Assoc · October 12, 2016 BACKGROUND: Diagnostic testing in the care of patients newly presenting with symptoms suggestive of coronary artery disease may influence risk factor management, independent of test type or test results. However, little is known about changes in medication ... Full text Open Access Link to item Cite

Health-related quality of life outcomes with prasugrel among medically managed non-ST-segment elevation acute coronary syndrome patients: Insights from the Targeted Platelet Inhibition to Clarify the Optimal Strategy to Medically Manage Acute Coronary Syndromes (TRILOGY ACS) trial.

Journal Article Am Heart J · August 2016 BACKGROUND: Few studies have assessed treatment effects on health-related quality of life (HRQoL) in patients with acute coronary syndrome (ACS) treated without revascularization. The TRILOGY ACS trial randomized patients with ACS to either prasugrel or cl ... Full text Link to item Cite

Economic Outcomes With Anatomical Versus Functional Diagnostic Testing for Coronary Artery Disease.

Journal Article Ann Intern Med · July 19, 2016 BACKGROUND: PROMISE (PROspective Multicenter Imaging Study for Evaluation of Chest Pain) found that initial use of at least 64-slice multidetector computed tomography angiography (CTA) versus functional diagnostic testing strategies did not improve clinica ... Full text Open Access Link to item Cite

Sex Differences in Functional and CT Angiography Testing in Patients With Suspected Coronary Artery Disease.

Journal Article J Am Coll Cardiol · June 7, 2016 BACKGROUND: Although risk stratification is an important goal of cardiac noninvasive tests (NITs), few contemporary data exist on the prognostic value of different NITs according to patient sex. OBJECTIVES: The goal of this study was to compare the results ... Full text Link to item Cite

Quality-of-Life Outcomes With Anatomic Versus Functional Diagnostic Testing Strategies in Symptomatic Patients With Suspected Coronary Artery Disease: Results From the PROMISE Randomized Trial.

Journal Article Circulation · May 24, 2016 BACKGROUND: The Prospective Multicenter Imaging Study for Evaluation of Chest Pain (PROMISE) trial found that initial use of ≥64 detector-row computed tomography angiography versus standard functional testing strategies (exercise ECG, stress nuclear method ... Full text Link to item Cite

Heavy Metals, Cardiovascular Disease, and the Unexpected Benefits of Chelation Therapy.

Journal Article J Am Coll Cardiol · May 24, 2016 This review summarizes evidence from 2 lines of research previously thought to be unrelated: the unexpectedly positive results of TACT (Trial to Assess Chelation Therapy), and a body of epidemiological data showing that accumulation of biologically active ... Full text Link to item Cite

Assessing quality-of-life outcomes in cardiovascular clinical research.

Journal Article Nat Rev Cardiol · May 2016 The field of quality-of-life (QOL) measurement grew out of attempts in the 1960s and 1970s to connect the ever-increasing levels of public expenditure on technology-based health care for chronic diseases with evidence of the benefits and harms to patients. ... Full text Link to item Cite

Assessing Quality of Life and Medical Care in Chronic Angina: An Internet Survey.

Journal Article Interact J Med Res · April 28, 2016 BACKGROUND: Angina is a clinical syndrome whose recognition relies heavily on self-report, so its identification can be challenging. Most data come from cohorts identified by physicians and nurses at the point of care; however, current widespread access to ... Full text Link to item Cite

Sex Differences in Demographics, Risk Factors, Presentation, and Noninvasive Testing in Stable Outpatients With Suspected Coronary Artery Disease: Insights From the PROMISE Trial.

Journal Article JACC Cardiovasc Imaging · April 2016 OBJECTIVES: The aim of this study was to determine whether presentation, risk assessment, testing choices, and results differ by sex in stable symptomatic outpatients with suspected coronary artery disease (CAD). BACKGROUND: Although established CAD presen ... Full text Link to item Cite

How Reliable are Patient-Reported Rehospitalizations? Implications for the Design of Future Practical Clinical Studies.

Journal Article J Am Heart Assoc · January 25, 2016 BACKGROUND: Longitudinal clinical investigations often rely on patient reports to screen for postdischarge adverse outcomes events, yet few studies have examined the accuracy of such patient reports. METHODS AND RESULTS: Patients with acute myocardial infa ... Full text Open Access Link to item Cite

Effects of Ranolazine on Angina and Quality of Life After Percutaneous Coronary Intervention With Incomplete Revascularization: Results From the Ranolazine for Incomplete Vessel Revascularization (RIVER-PCI) Trial.

Journal Article Circulation · January 5, 2016 BACKGROUND: Angina often persists or returns in populations following percutaneous coronary intervention (PCI). We hypothesized that ranolazine would be effective in reducing angina and improving quality of life (QOL) in incomplete revascularization (ICR) ... Full text Link to item Cite

SCD-HeFT: Use of R-R interval statistics for long-term risk stratification for arrhythmic sudden cardiac death.

Journal Article Heart Rhythm · October 2015 BACKGROUND: In the Sudden Cardiac Death in Heart Failure Trial (SCD-HeFT), a significant fraction of the patients with congestive heart failure ultimately did not die suddenly of arrhythmic causes. Patients with CHF will benefit from better tools to identi ... Full text Link to item Cite

Comparison of quality-of-life measures after radial versus femoral artery access for cardiac catheterization in women: Results of the Study of Access Site for Enhancement of Percutaneous Coronary Intervention for Women quality-of-life substudy.

Journal Article Am Heart J · August 2015 BACKGROUND: In the SAFE-PCI for Women trial, patient preference for radial access for future procedures was greater than for femoral access. We sought to assess whether radial or femoral access impacts formal measures of quality-of-life (QOL) among women u ... Full text Link to item Cite

Outcomes of anatomical versus functional testing for coronary artery disease.

Journal Article N Engl J Med · April 2, 2015 BACKGROUND: Many patients have symptoms suggestive of coronary artery disease (CAD) and are often evaluated with the use of diagnostic testing, although there are limited data from randomized trials to guide care. METHODS: We randomly assigned 10,003 sympt ... Full text Link to item Cite

Survival benefit of the primary prevention implantable cardioverter-defibrillator among older patients: does age matter? An analysis of pooled data from 5 clinical trials.

Journal Article Circ Cardiovasc Qual Outcomes · March 2015 BACKGROUND: The impact of patient age on the risks of death or rehospitalization after primary prevention implantable cardioverter-defibrillator (ICD) placement is uncertain. METHODS AND RESULTS: Data from 5 major ICD trials were merged: the Multicenter Au ... Full text Link to item Cite

Economic analysis of ticagrelor therapy from a U.S. perspective: results from the PLATO study.

Journal Article J Am Coll Cardiol · February 10, 2015 BACKGROUND: Based on results of the PLATO (Platelet Inhibition and Patient Outcomes) trial comparing ticagrelor with clopidogrel therapy, the U.S. Food and Drug Administration approved ticagrelor in 2011 for reducing thrombotic cardiovascular events in pat ... Full text Link to item Cite

Catheter ablation for ventricular tachycardia in patients with an implantable cardioverter defibrillator (CALYPSO) pilot trial.

Journal Article J Cardiovasc Electrophysiol · February 2015 INTRODUCTION: We conducted this pilot randomized clinical trial to determine the feasibility of a large clinical trial aimed at testing whether early use of catheter ablation of ventricular tachycardia (VT) is superior to antiarrhythmic medications at redu ... Full text Link to item Cite

Primary prevention implantable cardioverter-defibrillators and survival in older women.

Journal Article JACC Heart Fail · February 2015 OBJECTIVES: The purpose of this study was to assess the benefit of primary prevention implantable cardioverter defibrillators (ICDs) in women. BACKGROUND: Clinical trials of primary prevention ICDs enrolled a limited number of women. METHODS: Using a prope ... Full text Link to item Cite

Outcomes of implantable cardioverter-defibrillator use in patients with comorbidities: results from a combined analysis of 4 randomized clinical trials.

Journal Article JACC Heart Fail · December 2014 OBJECTIVES: The aim of this study was to determine if the benefit of implantable cardioverter-defibrillators (ICDs) is modulated by medical comorbidity. BACKGROUND: Primary prevention ICDs improve survival in patients at risk for sudden cardiac death. Thei ... Full text Link to item Cite

Rationale and design of the GUIDE-IT study: Guiding Evidence Based Therapy Using Biomarker Intensified Treatment in Heart Failure.

Journal Article JACC Heart Fail · October 2014 OBJECTIVES: The GUIDE-IT (Guiding Evidence Based Therapy Using Biomarker Intensified Treatment in Heart Failure) study is designed to determine the safety, efficacy, and cost-effectiveness of a strategy of adjusting therapy with the goal of achieving and m ... Full text Link to item Cite

Quality-of-life outcomes with coronary artery bypass graft surgery in ischemic left ventricular dysfunction: a randomized trial.

Journal Article Ann Intern Med · September 16, 2014 BACKGROUND: The STICH (Surgical Treatment for Ischemic Heart Failure) trial compared a strategy of routine coronary artery bypass grafting (CABG) with guideline-based medical therapy for patients with ischemic left ventricular dysfunction. OBJECTIVE: To de ... Full text Link to item Cite

Cost-effectiveness of follow-up of pulmonary nodules incidentally detected on cardiac computed tomographic angiography in patients with suspected coronary artery disease.

Journal Article Circulation · August 19, 2014 BACKGROUND: Pulmonary nodules (PNs) are often detected incidentally during coronary computed tomographic (CT) angiography, which is increasingly being used to evaluate patients with chest pain symptoms. However, the efficiency of following up on incidental ... Full text Link to item Cite

Exercise capacity and mortality in patients with ischemic left ventricular dysfunction randomized to coronary artery bypass graft surgery or medical therapy: an analysis from the STICH trial (Surgical Treatment for Ischemic Heart Failure).

Journal Article JACC Heart Fail · August 2014 OBJECTIVES: The objective of this study was to assess the prognostic significance of exercise capacity in patients with ischemic left ventricular (LV) dysfunction eligible for coronary artery bypass graft surgery (CABG). BACKGROUND: Poor exercise capacity ... Full text Link to item Cite

Implantable cardioverter-defibrillators for primary prevention of sudden cardiac death in CKD: a meta-analysis of patient-level data from 3 randomized trials.

Journal Article Am J Kidney Dis · July 2014 BACKGROUND: The benefit of a primary prevention implantable cardioverter-defibrillator (ICD) among patients with chronic kidney disease is uncertain. STUDY DESIGN: Meta-analysis of patient-level data from randomized controlled trials. SETTING & POPULATION: ... Full text Link to item Cite

EDTA chelation therapy alone and in combination with oral high-dose multivitamins and minerals for coronary disease: The factorial group results of the Trial to Assess Chelation Therapy.

Journal Article Am Heart J · July 2014 BACKGROUND: Disodium ethylenediaminetetraacetic acid (EDTA) reduced adverse cardiac outcomes in a factorial trial also testing oral vitamins. This report describes the intent-to-treat comparison of the 4 factorial groups overall and in patients with diabet ... Full text Link to item Cite

Quality-of-life outcomes with a disodium EDTA chelation regimen for coronary disease: results from the trial to assess chelation therapy randomized trial.

Journal Article Circ Cardiovasc Qual Outcomes · July 2014 BACKGROUND: The National Institutes of Health.funded Trial to Assess Chelation Therapy (TACT) randomized 1708 stablecoronary disease patients aged .50 years who were .6 months post.myocardial infarction (2003.2010) to 40 infusions ofa multicomponent EDTA c ... Full text Link to item Cite

Unexpected deviation in circadian variation of ventricular arrhythmias: the SCD-HeFT (Sudden Cardiac Death in Heart Failure Trial).

Journal Article J Am Coll Cardiol · June 24, 2014 OBJECTIVES: This study sought to determine whether circadian patterns in ventricular arrhythmias (VAs) occur in a current primary prevention defibrillator (implantable cardioverter-defibrillator [ICD]) population. BACKGROUND: Cardiovascular events, includi ... Full text Link to item Cite

Use of the 6-min walk distance to identify variations in treatment benefits from implantable cardioverter-defibrillator and amiodarone: results from the SCD-HeFT (Sudden Cardiac Death in Heart Failure Trial).

Journal Article J Am Coll Cardiol · June 17, 2014 OBJECTIVES: The purpose of this study was to determine if 6-min walk test data assists in treatment decisions for patients with heart failure. BACKGROUND: In the SCD-HeFT (Sudden Cardiac Death in Heart Failure Trial), a pre-specified subgroup analysis show ... Full text Link to item Cite

Association between prophylactic implantable cardioverter-defibrillators and survival in patients with left ventricular ejection fraction between 30% and 35%.

Journal Article JAMA · June 4, 2014 IMPORTANCE: Clinical trials of prophylactic implantable cardioverter-defibrillators (ICDs) have included a minority of patients with a left ventricular ejection fraction (LVEF) between 30% and 35%. Because a large number of ICDs in the United States are im ... Full text Link to item Cite

PROspective Multicenter Imaging Study for Evaluation of chest pain: rationale and design of the PROMISE trial.

Journal Article Am Heart J · June 2014 BACKGROUND: Suspected coronary artery disease (CAD) is one of the most common, potentially life-threatening diagnostic problems clinicians encounter. However, no large outcome-based randomized trials have been performed to guide the selection of diagnostic ... Full text Link to item Cite

The effects of exercise on cardiovascular biomarkers in patients with chronic heart failure.

Journal Article Am Heart J · February 2014 BACKGROUND: Exercise training is recommended for chronic heart failure (HF) patients to improve functional status and reduce risk of adverse outcomes. Elevated plasma levels of amino-terminal pro-brain natriuretic peptide (NT-proBNP), high-sensitivity C-re ... Full text Link to item Cite

The effect of an EDTA-based chelation regimen on patients with diabetes mellitus and prior myocardial infarction in the Trial to Assess Chelation Therapy (TACT).

Journal Article Circ Cardiovasc Qual Outcomes · January 2014 BACKGROUND: The Trial to Assess Chelation Therapy (TACT) showed clinical benefit of an EDTA-based infusion regimen in patients aged ≥50 years with prior myocardial infarction. Diabetes mellitus before enrollment was a prespecified subgroup. METHODS AND RES ... Full text Link to item Cite

Oral high-dose multivitamins and minerals after myocardial infarction: a randomized trial.

Journal Article Ann Intern Med · December 17, 2013 BACKGROUND: Whether high-dose multivitamins are effective for secondary prevention of atherosclerotic disease is unknown. OBJECTIVE: To assess whether oral multivitamins reduce cardiovascular events and are safe. DESIGN: Double-blind, placebo-controlled, 2 ... Full text Link to item Cite

No benefit of a dual coil over a single coil ICD lead: evidence from the Sudden Cardiac Death in Heart Failure Trial.

Journal Article Heart Rhythm · July 2013 BACKGROUND: Dual coil implantable cardioverter-defibrillator (ICD) leads with a superior vena cava (SVC) electrode have been considered standard of care despite sparse data suggesting improved ICD defibrillation efficacy. SVC coils increase lead complexity ... Full text Link to item Cite

Survival benefit of primary prevention implantable cardioverter-defibrillator therapy after myocardial infarction: does time to implant matter? A meta-analysis using patient-level data from 4 clinical trials.

Journal Article Heart Rhythm · June 2013 BACKGROUND: Whether there is an optimal time to place an implantable cardioverter-defibrillator (ICD) more than 40 days after myocardial infarction (MI) in guideline-eligible patients is unknown. OBJECTIVE: To evaluate the effect of time from MI to randomi ... Full text Link to item Cite

Rapid-rate nonsustained ventricular tachycardia found on implantable cardioverter-defibrillator interrogation: relationship to outcomes in the SCD-HeFT (Sudden Cardiac Death in Heart Failure Trial).

Journal Article J Am Coll Cardiol · May 28, 2013 OBJECTIVES: The aim of this study was to examine rapid-rate nonsustained ventricular tachycardia (RR-NSVT) during routine implantable cardioverter-defibrillator (ICD) evaluation in patients with heart failure and its relationship to outcomes. BACKGROUND: T ... Full text Link to item Cite

Effect of disodium EDTA chelation regimen on cardiovascular events in patients with previous myocardial infarction: the TACT randomized trial.

Journal Article JAMA · March 27, 2013 IMPORTANCE: Chelation therapy with disodium EDTA has been used for more than 50 years to treat atherosclerosis without proof of efficacy. OBJECTIVE: To determine if an EDTA-based chelation regimen reduces cardiovascular events. DESIGN, SETTING, AND PARTICI ... Full text Link to item Cite

Impact of lung transplantation on recipient quality of life: a serial, prospective, multicenter analysis through the first posttransplant year.

Journal Article Chest · March 2013 BACKGROUND: Quality of life (QOL) is an important but understudied outcome after lung transplantation. Previous cross-sectional, single-center studies suggest improved QOL, but few prior longitudinal multicenter data exist regarding the effect of transplan ... Full text Link to item Cite

Thyroid function in heart failure and impact on mortality.

Journal Article JACC Heart Fail · February 2013 OBJECTIVES: The aim of this study was to investigate whether patients with systolic heart failure (HF) and abnormal thyroid function are at increased risk for death. BACKGROUND: Thyroid hormone homeostasis is vital to the optimal functioning of the cardiov ... Full text Link to item Cite

Survival of patients receiving a primary prevention implantable cardioverter-defibrillator in clinical practice vs clinical trials.

Journal Article JAMA · January 2, 2013 IMPORTANCE: Randomized clinical trials have shown that implantable cardioverter-defibrillator (ICD) therapy saves lives. Whether the survival of patients who received an ICD in primary prevention clinical trials differs from that of trial-eligible patients ... Full text Link to item Cite

The economics of heart failure.

Journal Article Heart Fail Clin · January 2013 Full text Link to item Cite

Results of the Trial to Assess Chelation Therapy

Conference CIRCULATION · December 4, 2012 Link to item Cite

Educational and psychological interventions to improve outcomes for recipients of implantable cardioverter defibrillators and their families: a scientific statement from the American Heart Association.

Journal Article Circulation · October 23, 2012 Significant mortality benefits have been documented in recipients of implantable cardioverter defibrillators (ICDs); however, the psychosocial distress created by the underlying arrhythmia and its potential treatments in patients and family members may be ... Full text Link to item Cite

Downstream testing and subsequent procedures after coronary computed tomographic angiography following coronary stenting in patients ≥65 years of age.

Journal Article Am J Cardiol · September 15, 2012 Limited data are available on the use of coronary computed tomographic angiography (CCTA) in patients who have received percutaneous coronary intervention (PCI). To evaluate patterns of cardiac testing including CCTA after PCI, we created a retrospective o ... Full text Link to item Cite

Relationship of female sex to outcomes after myocardial infarction with persistent total occlusion of the infarct artery: analysis of the Occluded Artery Trial (OAT).

Journal Article Am Heart J · March 2012 BACKGROUND: Long-term follow-up (up to 9 years) from the OAT allows for the examination of sex differences in outcomes and the effect of percutaneous coronary intervention (PCI) in a relatively homogeneous cohort of myocardial infarction (MI) survivors. ME ... Full text Link to item Cite

Design of the Trial to Assess Chelation Therapy (TACT).

Journal Article Am Heart J · January 2012 TACT is an National Institutes of Health-sponsored, randomized, double-blind, placebo-controlled, 2 × 2 factorial clinical trial testing the benefits and risks of 40 infusions of a multicomponent disodium EDTA chelation solution compared with placebo and o ... Full text Link to item Cite

Long-term effects of percutaneous coronary intervention of the totally occluded infarct-related artery in the subacute phase after myocardial infarction.

Journal Article Circulation · November 22, 2011 BACKGROUND: Despite observations suggesting a benefit for late opening of totally occluded infarct-related arteries after myocardial infarction, the Occluded Artery Trial (OAT) demonstrated no reduction in the composite of death, reinfarction, and class IV ... Full text Link to item Cite

Treatment with adenosine diphosphate receptor inhibitors-longitudinal assessment of treatment patterns and events after acute coronary syndrome (TRANSLATE-ACS) study design: expanding the paradigm of longitudinal observational research.

Journal Article Am Heart J · November 2011 BACKGROUND: Platelet inhibition is critical in reducing both short- and long-term atherothrombotic risks after acute myocardial infarction (MI), especially among patients managed with percutaneous coronary intervention (PCI). Currently available antiplatel ... Full text Link to item Cite

Utility of a simple algorithm to grade diastolic dysfunction and predict outcome after coronary artery bypass graft surgery.

Journal Article Ann Thorac Surg · June 2011 BACKGROUND: Inclusion of a measure of left ventricular diastolic dysfunction (LVDD) may improve risk prediction after cardiac surgery. Current LVDD grading guidelines rely on echocardiographic variables that are not always available or aligned to allow gra ... Full text Link to item Cite

Recovery expectations and long-term prognosis of patients with coronary heart disease.

Journal Article Arch Intern Med · May 23, 2011 BACKGROUND: Expectations of patients regarding their prospects for recovery have been shown to predict subsequent physical and social functioning. Evidence regarding the impact of expectations on clinical outcomes is limited. METHODS: At the inpatient serv ... Full text Link to item Cite

In reply

Journal Article JAMA · April 20, 2011 Full text Cite

Mortality benefits from implantable cardioverter-defibrillator therapy are not restricted to patients with remote myocardial infarction: an analysis from the Sudden Cardiac Death in Heart Failure Trial (SCD-HeFT).

Journal Article Heart Rhythm · March 2011 BACKGROUND: The implantable cardioverter-defibrillator (ICD) is an effective therapy for preventing sudden cardiac death (SCD) in patients with prior myocardial infarction (MI) and reduced left ventricular function; however, the optimal timing of ICD impla ... Full text Link to item Cite

Non-evidence-based ICD implantations in the United States.

Journal Article JAMA · January 5, 2011 CONTEXT: Practice guidelines do not recommend use of an implantable cardioverter-defibrillator (ICD) for primary prevention in patients recovering from a myocardial infarction or coronary artery bypass graft surgery and those with severe heart failure symp ... Full text Link to item Cite

An ECG index of myocardial scar enhances prediction of defibrillator shocks: an analysis of the Sudden Cardiac Death in Heart Failure Trial.

Journal Article Heart Rhythm · January 2011 BACKGROUND: Only a minority of patients receiving implantable cardioverter-defibrillators (ICDs) for the primary prevention of sudden death receive appropriate shocks, yet almost as many are subjected to inappropriate shocks and device complications. Ident ... Full text Link to item Cite

Loss of short-term symptomatic benefit in patients with an occluded infarct artery is unrelated to non-protocol revascularization: results from the Occluded Artery Trial (OAT).

Journal Article Am Heart J · January 2011 BACKGROUND: the OAT found that routine late (3-28 days post-myocardial infarction) percutaneous coronary intervention (PCI) of an occluded infarct-related artery did not reduce death, reinfarction, or heart failure relative to medical treatment (MED). Angi ... Full text Link to item Cite

ACCF/SCCT/ACR/AHA/ASE/ASNC/NASCI/SCAI/SCMR 2010 Appropriate Use Criteria for Cardiac Computed Tomography. A Report of the American College of Cardiology Foundation Appropriate Use Criteria Task Force, the Society of Cardiovascular Computed Tomography, the American College of Radiology, the American Heart Association, the American Society of Echocardiography, the American Society of Nuclear Cardiology, the North American Society for Cardiovascular Imaging, the Society for Cardiovascular Angiography and Interventions, and the Society for Cardiovascular Magnetic Resonance.

Journal Article Circulation · November 23, 2010 The American College of Cardiology Foundation, along with key specialty and subspecialty societies, conducted an appropriate use review of common clinical scenarios where cardiac computed tomography (CCT) is frequently considered. The present document is a ... Full text Link to item Cite

ACCF/SCCT/ACR/AHA/ASE/ASNC/NASCI/SCAI/SCMR 2010 appropriate use criteria for cardiac computed tomography. A report of the American College of Cardiology Foundation Appropriate Use Criteria Task Force, the Society of Cardiovascular Computed Tomography, the American College of Radiology, the American Heart Association, the American Society of Echocardiography, the American Society of Nuclear Cardiology, the North American Society for Cardiovascular Imaging, the Society for Cardiovascular Angiography and Interventions, and the Society for Cardiovascular Magnetic Resonance.

Journal Article J Am Coll Cardiol · November 23, 2010 The American College of Cardiology Foundation (ACCF), along with key specialty and subspecialty societies, conducted an appropriate use review of common clinical scenarios where cardiac computed tomography (CCT) is frequently considered. The present docume ... Full text Link to item Cite

In reply

Journal Article JAMA · November 17, 2010 Full text Cite

Gentamicin-collagen sponge for infection prophylaxis in colorectal surgery.

Journal Article N Engl J Med · September 9, 2010 BACKGROUND: Despite the routine use of prophylactic systemic antibiotics, surgical-site infection continues to be associated with significant morbidity and cost after colorectal surgery. The gentamicin-collagen sponge, an implantable topical antibiotic age ... Full text Link to item Cite

Effect of an implantable gentamicin-collagen sponge on sternal wound infections following cardiac surgery: a randomized trial.

Journal Article JAMA · August 18, 2010 CONTEXT: Despite the routine use of prophylactic systemic antibiotics, sternal wound infection still occurs in 5% or more of cardiac surgical patients and is associated with significant excess morbidity, mortality, and cost. The gentamicin-collagen sponge, ... Full text Link to item Cite

The impact of new and emerging clinical data on treatment strategies for atrial fibrillation.

Journal Article J Cardiovasc Electrophysiol · August 1, 2010 INTRODUCTION: The Atrial Fibrillation (AF) Exchange Group, an international multidisciplinary group concerned with the management of AF, was convened to review recent advances in the field and the potential impact on treatment strategies. METHODS: Issues d ... Full text Link to item Cite

Quality of life effects of automatic external defibrillators in the home: results from the Home Automatic External Defibrillator Trial (HAT).

Journal Article Am Heart J · April 2010 BACKGROUND: Public access automatic external defibrillators (AEDs) can save lives, but most deaths from out-of-hospital sudden cardiac arrest occur at home. The Home Automatic External Defibrillator Trial (HAT) found no survival advantage for adding a home ... Full text Link to item Cite

Representation of women in randomized clinical trials of cardiovascular disease prevention.

Journal Article Circ Cardiovasc Qual Outcomes · March 2010 BACKGROUND: The 2007 American Heart Association guidelines for cardiovascular disease prevention in women drew heavily on results from randomized clinical trials; however, representation of women in trials of cardiovascular disease prevention has not been ... Full text Link to item Cite

Evolution of the coronary care unit: clinical characteristics and temporal trends in healthcare delivery and outcomes.

Journal Article Crit Care Med · February 2010 OBJECTIVE: To describe long-term temporal trends in patient characteristics, processes of care, and in-hospital outcomes among unselected admissions within the contemporary coronary care unit. DESIGN: Hospital administrative database that records both paym ... Full text Link to item Cite

Planning the Safety of Atrial Fibrillation Ablation Registry Initiative (SAFARI) as a Collaborative Pan-Stakeholder Critical Path Registry Model: a Cardiac Safety Research Consortium "Incubator" Think Tank.

Journal Article Am Heart J · January 2010 Atrial fibrillation (AF) is a major public health problem in the United States that is associated with increased mortality and morbidity. Of the therapeutic modalities available to treat AF, the use of percutaneous catheter ablation of AF is expanding rapi ... Full text Link to item Cite

ACCF/SCCT/ACR/AHA/ASE/ASNC/NASCI/SCAI/SCMR 2010 Appropriate Use Criteria for Cardiac Computed Tomography. A Report of the American College of Cardiology Foundation Appropriate Use Criteria Task Force, the Society of Cardiovascular Computed Tomography, the American College of Radiology, the American Heart Association, the American Society of Echocardiography, the American Society of Nuclear Cardiology, the North American Society for Cardiovascular Imaging, the Society for Cardiovascular Angiography and Interventions, and the Society for Cardiovascular Magnetic Resonance.

Journal Article J Cardiovasc Comput Tomogr · 2010 The American College of Cardiology Foundation (ACCF), along with key specialty and subspecialty societies, conducted an appropriate use review of common clinical scenarios where cardiac computed tomography (CCT) is frequently considered. The present docume ... Full text Link to item Cite

Impact of implantable cardioverter-defibrillator, amiodarone, and placebo on the mode of death in stable patients with heart failure: analysis from the sudden cardiac death in heart failure trial.

Journal Article Circulation · December 1, 2009 BACKGROUND: The Sudden Cardiac Death in Heart Failure Trial (SCD-HeFT) demonstrated that implantable cardioverter-defibrillator (ICD) therapy reduces all-cause mortality in patients with New York Heart Association class II/III heart failure and a left vent ... Full text Link to item Cite

Reporting and representation of race/ethnicity in published randomized trials.

Journal Article Am Heart J · November 2009 BACKGROUND: Although adequate representation of specific subgroups (eg, women and the elderly) in randomized controlled trials (RCTs) has been under intense scrutiny, there are few data on representation by race. METHODS: Using all RCTs cited by the 2007 A ... Full text Link to item Cite

Maximizing survival benefit with primary prevention implantable cardioverter-defibrillator therapy in a heart failure population.

Journal Article Circulation · September 8, 2009 BACKGROUND: Although implantable cardioverter-defibrillator (ICD) therapy reduces mortality in moderately symptomatic heart failure patients with an ejection fraction Full text Link to item Cite

Assessing the economic attractiveness of coronary artery revascularization in chronic kidney disease patients.

Journal Article J Med Syst · August 2009 Chronic kidney disease (CKD) is associated with increased morbidity and mortality in coronary artery disease (CAD) patients. We compared the economic attractiveness of CAD revascularization procedures in patients with and without CKD. Our population includ ... Full text Link to item Cite

Assessment of activity status and survival according to the Canadian Cardiovascular Society angina classification.

Journal Article Can J Cardiol · July 2009 BACKGROUND: Despite its widespread use, limited data on the validity of the Canadian Cardiovascular Society angina (CCSA) classification relative to other measures of functional status have been reported. OBJECTIVE: To assess the validity of the CCSA class ... Full text Link to item Cite

Careers for clinician investigators.

Journal Article Circulation · June 9, 2009 Full text Link to item Cite

Prospective study of associations among positive emotion and functional status in older patients with coronary artery disease.

Journal Article J Gerontol B Psychol Sci Soc Sci · June 2009 We examined associations between positive emotion (PE) and functional status (Duke Activity Status Inventory) in 948 coronary artery disease (CAD) patients (35.1% women; age M = 70.1 years, SD = 6.3). Emotion and function measures were gathered during hosp ... Full text Link to item Cite

Quality of life and economic outcomes with surgical ventricular reconstruction in ischemic heart failure: results from the Surgical Treatment for Ischemic Heart Failure trial.

Journal Article Am Heart J · May 2009 BACKGROUND: Surgical ventricular reconstruction (SVR) is used in conjunction with coronary artery bypass graft surgery (CABG) to improve left ventricular function and clinical outcomes in selected patients with ischemic heart failure. The impact of SVR on ... Full text Link to item Cite

Percutaneous transluminal coronary angioplasty after infarction: More effort, little effect

Journal Article MMW-Fortschritte der Medizin · April 30, 2009 Cite

Reporting and Representation of Race in Published Randomized Trials

Journal Article JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY · March 10, 2009 Link to item Cite

AHA science advisory. Depression and coronary heart disease. Recommendations for screening, referral, and treatment. A science advisory from the American Heart Association Prevention Committee to the Council on Cardiovascular Nursing, Council on Clinical Cardiology, Council on Epidemiology and Prevention, and Interdisciplinary Council on Quality of Care Outcomes Research. Endorsed by the American Psychiatric Association.

Journal Article Prog Cardiovasc Nurs · March 2009 Depression is commonly present in patients with coronary heart disease (CHD) and is independently associated with increased cardiovascular morbidity and mortality. Screening tests for depressive symptoms should be applied to identify patients who may requi ... Full text Link to item Cite

Quality of life after late invasive therapy for occluded arteries.

Journal Article N Engl J Med · February 19, 2009 BACKGROUND: The open-artery hypothesis postulates that late opening of an infarct-related artery after myocardial infarction will improve clinical outcomes. We evaluated the quality-of-life and economic outcomes associated with the use of this strategy. ME ... Full text Link to item Cite

Do income level and race influence survival in patients receiving hemodialysis?

Journal Article Am J Med · February 2009 BACKGROUND: Residence in a lower-income area has been associated with higher mortality among patients receiving dialysis. We sought to determine whether these differences persist and whether the effect of income-area on mortality is different for African A ... Full text Link to item Cite

Defibrillators in Heart Failure and Quality of Life Reply

Journal Article NEW ENGLAND JOURNAL OF MEDICINE · January 8, 2009 Link to item Cite

Has American Heart Journal gone to the blogs?

Journal Article American Heart Journal · January 1, 2009 Full text Cite

Ejection fraction assessment and survival: an analysis of the Sudden Cardiac Death in Heart Failure Trial (SCD-HeFT).

Journal Article Am Heart J · December 2008 BACKGROUND: Ejection fraction (EF) is an important method of mortality prediction among cardiac patients, and has been used to identify the highest risk patients for enrollment in the defibrillator primary prevention trials. Evidence suggests that measures ... Full text Link to item Cite

Re-evaluating the volume-outcome relationship in hemodialysis patients.

Journal Article Health Policy · December 2008 OBJECTIVES: We sought to determine whether dialysis patient mortality rates are associated with differences in dialysis facility size, and whether this relationship differs among higher risk diabetic and lower-risk non-diabetic patients. METHODS: Using 186 ... Full text Link to item Cite

Empirical estimation of life expectancy from large clinical trials: use of left-truncated, right-censored survival analysis methodology.

Journal Article Stat Med · November 20, 2008 In the current era of ever-increasing health care costs, economic analyses are an essential component in the comprehensive evaluation of new medical interventions. Cost-effectiveness analysis (CEA)--the most common form of economic analysis used in medicin ... Full text Link to item Cite

Role of microvolt T-wave alternans in assessment of arrhythmia vulnerability among patients with heart failure and systolic dysfunction: primary results from the T-wave alternans sudden cardiac death in heart failure trial substudy.

Journal Article Circulation · November 11, 2008 BACKGROUND: Sudden cardiac death remains a leading cause of mortality despite advances in medical treatment for the prevention of ischemic heart disease and heart failure. Recent studies showed a benefit of implantable cardioverter defibrillator implantati ... Full text Link to item Cite

Clopidogrel use and bleeding after coronary artery bypass graft surgery.

Journal Article Am Heart J · November 2008 BACKGROUND: Short-term use of clopidogrel plus aspirin among patients with acute coronary syndrome reduces ischemic events, but concerns about coronary artery bypass graft (CABG) surgery-related bleeding limit its early use. METHODS: Using data from 4,794 ... Full text Link to item Cite

Depression and coronary heart disease: recommendations for screening, referral, and treatment: a science advisory from the American Heart Association Prevention Committee of the Council on Cardiovascular Nursing, Council on Clinical Cardiology, Council on Epidemiology and Prevention, and Interdisciplinary Council on Quality of Care and Outcomes Research: endorsed by the American Psychiatric Association.

Journal Article Circulation · October 21, 2008 Depression is commonly present in patients with coronary heart disease (CHD) and is independently associated with increased cardiovascular morbidity and mortality. Screening tests for depressive symptoms should be applied to identify patients who may requi ... Full text Link to item Cite

Predictors of outcome and the lack of effect of percutaneous coronary intervention across the risk strata in patients with persistent total occlusion after myocardial infarction: Results from the OAT (Occluded Artery Trial) study.

Journal Article JACC Cardiovasc Interv · October 2008 OBJECTIVES: This study sought to determine predictors of outcome and examine the influence of baseline risk on therapeutic impact of late mechanical opening of a persistently occluded infarct related artery after myocardial infarction in stable patients. B ... Full text Link to item Cite

Implantable cardioverter defibrillator therapy in patients with prior coronary revascularization in the Sudden Cardiac Death in Heart Failure Trial (SCD-HeFT).

Journal Article J Cardiovasc Electrophysiol · October 2008 INTRODUCTION: We conducted this study to examine the effect of the ICD on the outcomes of patients with prior coronary revascularization enrolled in the Sudden Cardiac Death in Heart Failure Trial (SCD-HeFT) and to assess the association of time from coron ... Full text Link to item Cite

Long-term economic outcomes associated with intensive versus moderate lipid-lowering therapy in coronary artery disease: results from the Treating to New Targets (TNT) Trial.

Journal Article Am Heart J · October 2008 BACKGROUND: In 10,001 patients with stable coronary artery disease (CAD) enrolled in the Treating to New Targets (TNT) trial, 80 mg/d of atorvastatin (high-dose regimen) reduced the composite primary end point of death from CAD, nonfatal myocardial infarct ... Full text Link to item Cite

Preventing tomorrow's sudden cardiac death today: dissemination of effective therapies for sudden cardiac death prevention.

Journal Article Am Heart J · October 2008 Because the burden of sudden cardiac death (SCD) is substantial, it is important to use all guideline-driven therapies to prevent SCD. Among those therapies is the implantable cardioverter defibrillator (ICD). When indicated, ICD use is beneficial and cost ... Full text Link to item Cite

Prognostic importance of defibrillator shocks in patients with heart failure.

Journal Article N Engl J Med · September 4, 2008 BACKGROUND: Patients with heart failure who receive an implantable cardioverter-defibrillator (ICD) for primary prevention (i.e., prevention of a first life-threatening arrhythmic event) may later receive therapeutic shocks from the ICD. Information about ... Full text Link to item Cite

Quality of life with defibrillator therapy or amiodarone in heart failure.

Journal Article N Engl J Med · September 4, 2008 BACKGROUND: Implantable cardioverter-defibrillator (ICD) therapy significantly prolongs life in patients at increased risk for sudden death from depressed left ventricular function. However, whether this increased longevity is accompanied by deterioration ... Full text Link to item Cite

No benefit from defibrillation threshold testing in the SCD-HeFT (Sudden Cardiac Death in Heart Failure Trial).

Journal Article J Am Coll Cardiol · August 12, 2008 OBJECTIVES: This study investigated whether defibrillation threshold (DFT) testing during implantable cardioverter-defibrillator (ICD) implantation predicts clinical outcomes. BACKGROUND: Defibrillation testing is often performed during insertion of ICDs t ... Full text Link to item Cite

Long-term clinical outcomes following coronary stenting.

Journal Article Arch Intern Med · August 11, 2008 BACKGROUND: Clinical trials of drug-eluting stents (DES) vs bare metal stents (BMS) report a reduced need for target lesion revascularization with no difference in death or myocardial infarction. However, these trials selectively enrolled patients with low ... Full text Link to item Cite

Primary prevention with defibrillator therapy in women: results from the Sudden Cardiac Death in Heart Failure Trial.

Journal Article J Cardiovasc Electrophysiol · July 2008 INTRODUCTION: The Sudden Cardiac Death in Heart Failure Trial (SCD-HeFT) demonstrated that implantable cardioverter defibrillator (ICD) therapy reduced overall mortality in patients with class II or III heart failure and left ventricular ejection fraction ... Full text Link to item Cite

Strategies for incorporating resource allocation and economic considerations: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition).

Journal Article Chest · June 2008 Although clinical guidelines may have substantial implications for allocation of health-care resources, these issues typically are not considered in the guideline development process or are only considered informally. This is a particular challenge for gui ... Full text Link to item Cite

The primary and secondary prevention of coronary artery disease: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition).

Journal Article Chest · June 2008 The following chapter devoted to antithrombotic therapy for chronic coronary artery disease (CAD) is part of the Antithrombotic and Thrombolytic Therapy: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). Grade ... Full text Link to item Cite

Home use of automated external defibrillators for sudden cardiac arrest.

Journal Article N Engl J Med · April 24, 2008 BACKGROUND: The most common location of out-of-hospital sudden cardiac arrest is the home, a situation in which emergency medical services are challenged to provide timely care. Consequently, home use of an automated external defibrillator (AED) might offe ... Full text Link to item Cite

Syncope predicts the outcome of cardiomyopathy patients: analysis of the SCD-HeFT study.

Journal Article J Am Coll Cardiol · April 1, 2008 OBJECTIVES: The outcome of congestive heart failure (CHF) patients with syncope is understood incompletely. BACKGROUND: We analyzed data from patients enrolled in the SCD-HeFT (Sudden Cardiac Death Heart Failure Trial) to determine whether syncope predicte ... Full text Link to item Cite

Representation of women in randomized clinical trials of cardiovascular disease prevention

Conference JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY · March 11, 2008 Link to item Cite

Rationale and design of the Home Automatic External Defibrillator Trial (HAT).

Journal Article Am Heart J · March 2008 Most cardiac arrests occur in the home, where emergency medical services (EMS) systems are challenged to provide timely care. Because a large proportion of sudden cardiac arrests (SCAs) are due to ventricular tachycardia or ventricular fibrillation, home u ... Full text Link to item Cite

Outcome in African Americans and other minorities in the Sudden Cardiac Death in Heart Failure Trial (SCD-HeFT).

Journal Article Am Heart J · March 2008 BACKGROUND: The SCD-HeFT demonstrated that implantable cardioverter/defibrillator (ICD) therapy significantly improved survival compared to medical therapy alone in stable moderately symptomatic heart failure patients with an ejection fraction < or = 35%. ... Full text Link to item Cite

Clinical and research issues regarding chronic advanced coronary artery disease part II: Trial design, outcomes, and regulatory issues.

Journal Article Am Heart J · March 2008 The population of patients with advanced coronary artery disease (CAD) is growing as a result of the aging of the general population, the extensive use of revascularization, and the efficacy of therapies that have prolonged the survival of patients with se ... Full text Link to item Cite

Clinical and research issues regarding chronic advanced coronary artery disease: part I: Contemporary and emerging therapies.

Journal Article Am Heart J · March 2008 The following report is based on a working group meeting about advanced coronary artery disease for patients with refractory ischemia who cannot receive revascularization. The aims were to review currently available treatment strategies, define unmet clini ... Full text Link to item Cite

Association between bleeding, blood transfusion, and costs among patients with non-ST-segment elevation acute coronary syndromes.

Journal Article Am Heart J · February 2008 BACKGROUND: Bleeding and blood transfusion are associated with increased morbidity and mortality among patients with non-ST-segment elevation acute coronary syndromes (NSTE ACS); however, the economic consequences of these complications are not well define ... Full text Link to item Cite

PCI in the OAT trial: Lots of bucks, not much bang (EQOL OAT)

Journal Article ACC Cardiosource Review Journal · January 1, 2008 The Occluded Artery Trial (OAT) evaluated the use of percutaneous coronary intervention (PCI) for an occluded coronary artery. In patients with a total occluded artery, the medical therapy alone (MED) strategy was more cost-effective than the PCI strategy. ... Cite

The rationale and design of the Surgical Treatment for Ischemic Heart Failure (STICH) trial.

Journal Article J Thorac Cardiovasc Surg · December 2007 OBJECTIVES: The rationale and design of the Surgical Treatment for Ischemic Heart Failure trial is described. Before the Surgical Treatment for Ischemic Heart Failure trial, less than 1000 patients with ischemic cardiomyopathy had been studied in randomize ... Full text Link to item Cite

PCI in the OAT trial: Lots of bucks, not much bang

Conference CIRCULATION · November 27, 2007 Link to item Cite

Cardiovascular disease on a global scale: defining the path forward for research and practice.

Journal Article Eur Heart J · November 2007 During the 2006 World Congress of Cardiology meeting in Barcelona, the Virtual Coordinating Centre for Global Collaborative Cardiovascular Research (VIGOUR) group held a symposium examining potential approaches to understanding and controlling the explosiv ... Full text Link to item Cite

Percutaneous coronary revascularisation: is it ever worth what it costs?

Journal Article Heart · October 2007 “How could percutaneous coronary intervention without the risks and morbidities of heart surgery not be of benefit to patients? Hard experience teaches that such attractive “pathophysiological” simplifications are unreliable guides to practice and paradoxi ... Full text Link to item Cite

Impact of rate-modulated pacing on quality of life and exercise capacity--evidence from the Advanced Elements of Pacing Randomized Controlled Trial (ADEPT).

Journal Article Heart Rhythm · September 2007 BACKGROUND: Ninety-nine percent of pacemakers implanted in the United States include an option for rate modulation. OBJECTIVE: The purpose of this study was to determine whether dual-chamber rate-modulated pacing, when compared with dual-chamber pacing alo ... Full text Link to item Cite

What we publish in the American Heart Journal and why

Journal Article American Heart Journal · July 1, 2007 Full text Cite

Preventing tomorrow's sudden cardiac death today: part I: Current data on risk stratification for sudden cardiac death.

Journal Article Am Heart J · June 2007 Accurate and timely prediction of sudden cardiac death (SCD) is a necessary prerequisite for effective prevention and therapy. Although the largest number of SCD events occurs in patients without overt heart disease, there are currently no tests that are o ... Full text Link to item Cite

Impact of residency status on perfusion times and outcomes for coronary artery bypass graft surgery.

Journal Article Ann Thorac Surg · June 2007 BACKGROUND: A price of training residents in cardiothoracic surgery is often perceived to be a loss in intraoperative efficiencies, leading to prolonged cardiopulmonary bypass and perfusion time. Because these indicators are also thought to adversely affec ... Full text Link to item Cite

Where patients with mild to moderate heart failure die: results from the Sudden Cardiac Death in Heart Failure Trial (SCD-HeFT).

Journal Article Am Heart J · June 2007 BACKGROUND: Common locations of death in patients with congestive heart failure (CHF) are unknown. In the SCD-HeFT, mortality of patients with CHF was assessed after randomization to an implantable cardioverter/defibrillator (ICD), amiodarone, or placebo. ... Full text Link to item Cite

Preventing tomorrow's sudden cardiac death today: part II: Translating sudden cardiac death risk assessment strategies into practice and policy.

Journal Article Am Heart J · June 2007 Although current evidence supporting a more precise strategy for identifying patients at highest risk for sudden cardiac death (SCD) is sparse, strategies for translating existing and future evidence into clinical practice and policy are needed today. A gr ... Full text Link to item Cite

Risk of thromboembolism in heart failure: an analysis from the Sudden Cardiac Death in Heart Failure Trial (SCD-HeFT).

Journal Article Circulation · May 22, 2007 BACKGROUND: In patients with heart failure, rates of clinically apparent stroke range from 1.3% to 3.5% per year. Little is known about the incidence and risk factors in the absence of atrial fibrillation. In the Sudden Cardiac Death in Heart Failure Trial ... Full text Link to item Cite

Absence of bilateral vision loss from amiodarone: a randomized trial.

Journal Article Am Heart J · May 2007 BACKGROUND: Amiodarone's role as a cause of toxic optic neuropathy is based on case reports. Annual frequency estimates of 0.36% to 2.0%, which have been made without reference to the dose or duration of treatment, are 12 to 200 times higher than those for ... Full text Link to item Cite

Facets of openness predict mortality in patients with cardiac disease.

Journal Article Psychosom Med · May 2007 OBJECTIVE: To examine the NEO Personality Inventory (NEO PI) Openness to Experience (O) domain and its facets as predictors of cardiac deaths and all-cause mortality. METHODS: The NEO PI was administered to a sample of 977 coronary catheterization patients ... Full text Link to item Cite

Myocardial infarction following coronary artery bypass graft surgery increases healthcare resource utilization.

Journal Article Crit Care Med · May 2007 OBJECTIVE: To assess the health economic impact of perioperative myocardial infarction in a cohort of patients undergoing coronary artery bypass graft surgery. DESIGN: Retrospective cohort analysis using data from hospital bills and uniform billing forms. ... Full text Link to item Cite

Statin use was associated with reduced mortality in both ischemic and nonischemic cardiomyopathy and in patients with implantable defibrillators: mortality data and mechanistic insights from the Sudden Cardiac Death in Heart Failure Trial (SCD-HeFT).

Journal Article Am Heart J · April 2007 BACKGROUND: Recent observations suggest statin treatment may be associated with lower mortality in heart failure (HF). The SCD-HeFT was a study of 2521 functional class II and III HF patients with left ventricular ejection fractions < or = 35% and ischemic ... Full text Link to item Cite

Noninvasive imaging for coronary artery disease: a technology assessment for the Medicare Coverage Advisory Commission.

Journal Article Am Heart J · February 2007 This report describes a review of the available scientific evidence through 2005 on direct noninvasive imaging tests (NITs) for coronary artery disease. In particular, the report addresses 6 key questions provided by the Agency for Healthcare Research and ... Full text Link to item Cite

The high cost of implantable defibrillators.

Journal Article Eur Heart J · February 2007 Increased use of ICDs in patients with cardiac disease has the potential to strain national health care budgets because of the large numbers of eligible patients and the high cost of the ICDs. Randomized trials show ICDs increase life-expectancy in some gr ... Full text Link to item Cite

Long-term costs and resource use in elderly participants with congestive heart failure in the Cardiovascular Health Study.

Journal Article Am Heart J · February 2007 BACKGROUND: Although heart failure (HF) afflicts nearly 5 million Americans, the long-term cost of HF care has not been described previously. In a prospective, longitudinal cohort of community-dwelling elderly from 4 regions, we examined the long-term cost ... Full text Link to item Cite

Clopidogrel use and long-term clinical outcomes after drug-eluting stent implantation.

Journal Article JAMA · January 10, 2007 CONTEXT: Recent studies of drug-eluting intracoronary stents suggest that current antiplatelet regimens may not be sufficient to prevent late stent thrombosis. OBJECTIVE: To assess the association between clopidogrel use and long-term clinical outcomes of ... Full text Link to item Cite

Is early too early? Effect of shorter stays after bypass surgery.

Journal Article Ann Thorac Surg · January 2007 BACKGROUND: Postoperative stays after coronary artery bypass graft surgery (CABG) decreased substantially in the 1990s. Although shorter stays offer clinical benefits, premature discharge could increase adverse events and offset initial savings. This study ... Full text Link to item Cite

Coronary intervention for persistent occlusion after myocardial infarction.

Journal Article N Engl J Med · December 7, 2006 BACKGROUND: It is unclear whether stable, high-risk patients with persistent total occlusion of the infarct-related coronary artery identified after the currently accepted period for myocardial salvage has passed should undergo percutaneous coronary interv ... Full text Link to item Cite

Trends in postoperative length of stay after bypass surgery.

Journal Article Am Heart J · December 2006 BACKGROUND: Although single-site studies have reported reductions in coronary artery bypass graft (CABG) surgery length of stay (LOS) over the last 15 years, less information is available regarding overall temporal trends and interhospital variability. Thi ... Full text Link to item Cite

Role of amiodarone or implantable cardioverter/defibrillator in patients with atrial fibrillation and heart failure.

Journal Article Am Heart J · November 2006 BACKGROUND: Heart failure complicated by atrial fibrillation (AF) is associated with excessive mortality and morbidity. The aim of the study was to determine the role of amiodarone or implantable cardioverter/defibrillator (ICD) in patients with AF and hea ... Full text Link to item Cite

Natriuretic peptides in the diagnosis and management of heart failure.

Journal Article CMAJ · September 12, 2006 The natriuretic peptides are a family of related hormones that play a crucial role in cardiovascular homeostasis. They have recently emerged as potentially important clinical markers in heart failure. Recent data have suggested an important role for these ... Full text Link to item Cite

Central nervous system injury associated with cardiac surgery.

Journal Article Lancet · August 19, 2006 Millions of individuals with coronary artery or valvular heart disease have been given a new chance at life by heart surgery, but the potential for neurological injury is an Achilles heel. Technological advancements and innovations in surgical and anaesthe ... Full text Link to item Cite

Cost-effectiveness of defibrillator therapy or amiodarone in chronic stable heart failure: results from the Sudden Cardiac Death in Heart Failure Trial (SCD-HeFT).

Journal Article Circulation · July 11, 2006 BACKGROUND: In the Sudden Cardiac Death in Heart Failure Trial (SCD-HeFT), implantable cardioverter-defibrillator (ICD) therapy significantly reduced all-cause mortality rates compared with medical therapy alone in patients with stable, moderately symptoma ... Full text Link to item Cite

What is the economic value of digoxin therapy in congestive heart failure patients? Results from the DIG trial.

Journal Article J Card Fail · June 2006 BACKGROUND: The Digitalis Investigation Group (DIG) clinical train randomized 6800 congestive heart failure patients (ejection fraction > or =45%) to a daily regimen of either digoxin or placebo. At 37 months average follow-up, patients in both groups had ... Full text Link to item Cite

The value of estimated functional capacity in estimating outcome: results from the NHBLI-Sponsored Women's Ischemia Syndrome Evaluation (WISE) Study.

Journal Article J Am Coll Cardiol · February 7, 2006 OBJECTIVES: Our objective was to determine the prognostic value of estimated metabolic equivalents (METs) based on self-reported functional capacity by the Duke Activity Status Index (DASI) in symptomatic women. BACKGROUND: Functional capacity is an import ... Full text Link to item Cite

Costs for heart failure with normal vs reduced ejection fraction.

Journal Article Arch Intern Med · January 9, 2006 BACKGROUND: Among the elderly population, heart failure (HF) with normal ejection fraction (EF) is more common than classic HF with low EF. However, there are few data regarding the costs of HF with normal EF. In a prospective, population-based cohort of e ... Full text Link to item Cite

Implications of the Multicenter Automatic Defibrillator Implantation Trial-II

Journal Article Annals of Internal Medicine · January 3, 2006 Full text Cite

Association of neurocognitive function and quality of life 1 year after coronary artery bypass graft (CABG) surgery.

Journal Article Psychosom Med · 2006 OBJECTIVE: Although coronary artery bypass grafting (CABG) has been shown to improve quality of life and functional capacity for many patients, recent studies have demonstrated that a significant number of patients exhibit impairment in cognitive function ... Full text Link to item Cite

Cardiac resynchronization therapy: Part 2--issues during and after device implantation and unresolved questions.

Journal Article J Am Coll Cardiol · December 20, 2005 Encouraged by the clinical success of cardiac resynchronization therapy (CRT), the implantation rate has increased exponentially, although several limitations and unresolved issues of CRT have been identified. This review concerns issues that are encounter ... Full text Link to item Cite

Cardiac resynchronization therapy: Part 1--issues before device implantation.

Journal Article J Am Coll Cardiol · December 20, 2005 Cardiac resynchronization therapy (CRT) has been used extensively over the last years in the therapeutic management of patients with end-stage heart failure. Data from 4,017 patients have been published in eight large, randomized trials on CRT. Improvement ... Full text Link to item Cite

The MANTRA II study.

Journal Article Lancet · November 19, 2005 Full text Link to item Cite

A new anatomic score for prognosis after cardiac catheterization in patients with previous bypass surgery.

Journal Article J Am Coll Cardiol · November 1, 2005 OBJECTIVES: The purpose of this study was to determine the value of a new anatomic score for prognosis after diagnostic catheterization in patients with previous coronary artery bypass grafting (CABG). BACKGROUND: Previous CABG patients comprise a growing ... Full text Link to item Cite

Design and methodology of the Occluded Artery Trial (OAT).

Journal Article Am Heart J · October 2005 Experimental and clinical studies have suggested that late opening of an infarct-related artery (IRA) after myocardial infarction (MI) could improve clinical outcome. However, the suggestive observational data are limited by selection biases. Indeed, most ... Full text Link to item Cite

Prognostic/Clinical Prediction Models: Using Observational Data to Estimate Prognosis: An Example Using a Coronary Artery Disease Registry

Chapter · August 24, 2005 With the proliferation of clinical data registries and the rising expense of clinical trials, observational data sources are increasingly providing evidence for clinical decision making. These data are viewed as complementary to randomized clinical trials ... Full text Cite

Prognostic/Clinical Prediction Models: Multivariable Prognostic Models: Issues in Developing Models, Evaluating Assumptions and Adequacy, and Measuring and Reducing Errors

Chapter · August 24, 2005 Multivariable regression models are powerful tools that are used frequently in studies of clinical outcomes. These models can use a mixture of categorical and continuous variables and can handle partially observed (censored) responses. However, uncritical ... Full text Cite

Music, imagery, touch, and prayer as adjuncts to interventional cardiac care: the Monitoring and Actualisation of Noetic Trainings (MANTRA) II randomised study.

Journal Article Lancet · July 16, 2005 BACKGROUND: Data from a pilot study suggested that noetic therapies-healing practices that are not mediated by tangible elements-can reduce preprocedural distress and might affect outcomes in patients undergoing percutaneous coronary intervention. We under ... Full text Link to item Cite

Relation between baseline risk and treatment decisions in non-ST elevation acute coronary syndromes: an examination of international practice patterns.

Journal Article Heart · July 2005 OBJECTIVES: To examine the interaction between ST segment depression on the baseline ECG and subsequent in-hospital revascularisation on six month mortality among patients with non-ST elevation acute coronary syndromes. To examine whether ST segment depres ... Full text Link to item Cite

Hostility, age, and mortality in a sample of cardiac patients.

Journal Article Am J Cardiol · July 1, 2005 This study examined hostility as a predictor of survival in a sample of 1,328 patients who had documented coronary artery disease. After controlling for disease severity, there was a significant interaction between age and hostility. Hostility was signific ... Full text Link to item Cite

Implantable cardioverter defibrillators and cardiac resynchronization therapy in patients with left ventricular dysfunction: randomized trial evidence through 2004.

Journal Article Am Heart J · June 2005 Although many studies have shown that implantable cardioverter defibrillator (ICD) therapy improves the survival of patients with significant left ventricular dysfunction, the magnitude of effectiveness of ICD therapy in clinically defined subgroups remain ... Full text Link to item Cite

Implantable cardioverter-defibrillators.

Journal Article N Engl J Med · May 12, 2005 Link to item Cite

Ratings of positive and depressive emotion as predictors of mortality in coronary patients.

Journal Article Int J Cardiol · April 20, 2005 BACKGROUND: An extensive body of research has demonstrated an association between negative affective states and health outcomes. Positive emotions may also influence physical health, however, their examination has received far less attention. METHODS: Posi ... Full text Link to item Cite

Clinical and economic implications of the Multicenter Automatic Defibrillator Implantation Trial-II.

Journal Article Ann Intern Med · April 19, 2005 BACKGROUND: The Multicenter Automatic Defibrillator Implantation Trial (MADIT)-II demonstrated that implantable cardioverter defibrillators (ICDs) save lives when used in patients with a history of myocardial infarction (MI) and an ejection fraction of 0.3 ... Full text Link to item Cite

Economic analysis of the Assessment of the Safety and Efficacy of a New Thrombolytic Regimen (ASSENT-3) study: costs of reperfusion strategies in acute myocardial infarction.

Journal Article Am Heart J · April 2005 BACKGROUND: The ASSENT-3 study examined the safety and efficacy of 3 alternative regimens for ST-elevation acute myocardial infarction: full-dose tenecteplase (TNK-tPA) plus enoxaparin; half-dose TNK-tPA plus unfractionated heparin plus abciximab; and full ... Full text Link to item Cite

Surgeons' economic profiles: can we get the "right" answers?

Journal Article J Med Syst · April 2005 Hospitals and payers use economic profiling to evaluate physician and surgeon performance. However, there is significant variation in the data sources and analytic methods that are used. We used information from a hospital's cardiac surgery and cost accoun ... Full text Link to item Cite

Conducting economic evaluations alongside multinational clinical trials: toward a research consensus.

Journal Article Am Heart J · March 2005 Demand for economic evaluations in multinational clinical trials is increasing, but there is little consensus about how such studies should be conducted and reported. At a workshop in Durham, North Carolina, we sought to identify areas of agreement about h ... Full text Link to item Cite

Research, managed care, and patient privacy: Challenges to successful collaboration

Journal Article Journal of Clinical Outcomes Management · March 1, 2005 • Objective: To illustrate the impact of increased patient privacy concerns on the conduct of research on managed care patients and to suggest mechanisms for successful collaboration between managed care organizations and academic research organizations. • ... Cite

Amiodarone or an implantable cardioverter-defibrillator for congestive heart failure.

Journal Article N Engl J Med · January 20, 2005 BACKGROUND: Sudden death from cardiac causes remains a leading cause of death among patients with congestive heart failure (CHF). Treatment with amiodarone or an implantable cardioverter-defibrillator (ICD) has been proposed to improve the prognosis in suc ... Full text Link to item Cite

Perceived social support as a predictor of mortality in coronary patients: effects of smoking, sedentary behavior, and depressive symptoms.

Journal Article Psychosom Med · 2005 OBJECTIVE: Numerous studies have shown network assessments of social contact predict mortality in patients with coronary artery disease (CAD). Fewer studies have demonstrated an association between perceived social support and longevity in patient samples. ... Full text Link to item Cite

Fixing the heart: must the brain pay the price?

Journal Article Circulation · November 30, 2004 Full text Link to item Cite

Prognostic value of predischarge electrocardiographic measurement of infarct size after thrombolysis: insights from GUSTO I Economics and Quality of Life substudy.

Journal Article Am Heart J · November 2004 BACKGROUND: Current methods for risk stratification after acute myocardial infarction (MI) include several noninvasive studies. In this cost-containment era, the development of low-cost means should be encouraged. We assessed the ability of an electrocardi ... Full text Link to item Cite

Medical costs and quality of life 10 to 12 years after randomization to angioplasty or bypass surgery for multivessel coronary artery disease.

Journal Article Circulation · October 5, 2004 BACKGROUND: Coronary bypass surgery (CABG) and angioplasty (PTCA) have been compared in several randomized trials, but data about long-term economic and quality-of-life outcomes are limited. METHODS AND RESULTS: Cost and quality-of-life data were collected ... Full text Link to item Cite

Long-term mortality of patients with acute myocardial infarction in the United States and Canada: comparison of patients enrolled in Global Utilization of Streptokinase and t-PA for Occluded Coronary Arteries (GUSTO)-I.

Journal Article Circulation · September 28, 2004 BACKGROUND: In a previous substudy of the GUSTO-I trial, we observed better functional and quality-of-life outcomes among patients in the United States (US patients) compared with patients in Canada. Rates of invasive therapy were significantly higher in t ... Full text Link to item Cite

Impact of different patterns of invasive care on quality of life outcomes in patients with non-ST elevation acute coronary syndrome: results from the GUSTO-IIb Canada-United States substudy.

Journal Article Can J Cardiol · June 2004 BACKGROUND: Comparing American and Canadian practice patterns and outcomes offers a natural experiment to examine the relative benefits of aggressive versus conservative management of coronary artery disease. In a prospective substudy of the Global Use of ... Link to item Cite

Economic impact of drug-eluting stents on hospital systems: a disease-state model.

Journal Article Am Heart J · March 2004 BACKGROUND: Drug-eluting intracoronary stents decrease restenosis and later revascularization. The US Department of Health and Human Services (HHS), recognizing the financial and clinical impact of this technology, recently proposed accelerated reimburseme ... Full text Link to item Cite

The prognostic importance of comorbidity for mortality in patients with stable coronary artery disease.

Journal Article J Am Coll Cardiol · February 18, 2004 OBJECTIVES: To identify the prevalent and prognostically important coexisting illnesses among single coronary artery disease (CAD) patients. BACKGROUND: As the population ages, physicians are increasingly required to make decisions concerning patients with ... Full text Link to item Cite

International differences in evolution of early discharge after acute myocardial infarction.

Journal Article Lancet · February 14, 2004 BACKGROUND: Early discharge of low-risk patients with acute myocardial infarction is feasible and can be achieved at no additional risk of adverse events. We aimed to identify the extent to which countries have taken advantage of the opportunity for early ... Full text Link to item Cite

Prospective study of perceived stress in cardiac patients.

Journal Article Ann Behav Med · February 2004 BACKGROUND: Psychological stress is known to have a negative effect on the health and well-being of coronary artery disease (CAD) patients. Although the study of stress CAD samples has received considerable attention, few studies have examined the effects ... Full text Link to item Cite

Cost-Effectiveness of New Diagnostic Tools and Therapies for Acute Coronary Syndromes

Chapter · January 1, 2004 INTRODUCTION Three 20th century trends have converged to create today’s technology-driven health care system [1]. First, increasing life expectancy (49.2 years in 1900 vs. 77.2 years in 2001 for the United States) means that people live long enough to deve ... Full text Cite

Exploring options for improving healthcare.

Journal Article Am Heart J · January 2004 New medical technologies generally must receive clearance or approval for marketing by the US Food and Drug Administration and be covered by an insurer, such as the Centers for Medicare and Medicaid Services, before becoming available for widespread clinic ... Full text Link to item Cite

Hostility as a predictor of survival in patients with coronary artery disease.

Journal Article Psychosom Med · 2004 OBJECTIVE: This article presents a reanalysis of an earlier study that reported a nonsignificant relation between the 50-item Cook-Medley Hostility Scale (CMHS) and survival in a sample of coronary patients. Since publication of those results, there have b ... Full text Link to item Cite

Cerebral embolization during cardiac surgery: impact of aortic atheroma burden.

Other Br J Anaesth · November 2003 BACKGROUND: Aortic atheromatous disease is known to be associated with an increased risk of perioperative stroke in the setting of cardiac surgery. In this study, we sought to determine the relationship between cerebral microemboli and aortic atheroma burd ... Full text Link to item Cite

Clinical prediction models: are we building better mousetraps?

Journal Article J Am Coll Cardiol · September 3, 2003 Full text Link to item Cite

Effect of smoking and sedentary behavior on the association between depressive symptoms and mortality from coronary heart disease.

Journal Article Am J Cardiol · September 1, 2003 It has been suggested that one of the mechanisms linking depression with elevated mortality risk is the association between depressive symptoms and other established coronary artery disease (CAD) risk factors, such as smoking and failure to exercise. The p ... Full text Link to item Cite

Chronic kidney disease, mortality, and treatment strategies among patients with clinically significant coronary artery disease.

Journal Article J Am Soc Nephrol · September 2003 Cardiovascular disease is an important cause of mortality among patients with chronic kidney disease (CKD). This study describes associations between CKD, cardiac revascularization strategies, and mortality among patients with CKD and cardiovascular diseas ... Full text Link to item Cite

Depression as a risk factor for mortality after coronary artery bypass surgery.

Journal Article Lancet · August 23, 2003 BACKGROUND: Studies that have shown clinical depression to be a risk factor for cardiac events after coronary artery bypass graft (CABG) surgery have had small sample sizes, short follow-up, and have not had adequate power to assess mortality. We sought to ... Full text Link to item Cite

Poverty, process of care, and outcome in acute coronary syndromes.

Journal Article J Am Coll Cardiol · June 4, 2003 OBJECTIVES: We sought to determine whether income-based disparities in care processes and outcome exist in patients with acute coronary syndromes. BACKGROUND: Using income proxies and limited clinical data, some observational studies have shown income disp ... Full text Link to item Cite

34th Bethesda Conference: Can atherosclerosis imaging techniques improve the detection of patients at risk for ischemic heart disease?

Journal Article Journal of the American College of Cardiology · June 4, 2003 This document presents the summary findings from the 34th Bethesda Conference: "Can Atherosclerosis Imaging Techniques Improve the Detection of Patients at Risk for Ischemic Heart Disease?" This conference, comprised of five writing groups, began the proce ... Full text Cite

Impact of on-site cardiac interventional facilities on management and outcome of patients with acute coronary syndromes.

Journal Article Can J Cardiol · March 15, 2003 OBJECTIVES: To investigate the impact of on-site cardiac interventional facilities on the management and outcome of patients with versus those without ST elevation acute coronary syndromes (ACS) in the Canadian-American Global Use of Strategies to Open Occ ... Link to item Cite

Development and validation of a simple model to predict severe coronary artery disease after myocardial infarction: potential impact on cardiac catheterization use in the United States and Canada.

Journal Article Am Heart J · February 2003 BACKGROUND: Improved patient selection may optimize the efficiency of cardiac catheterization in both high- and low-rate regions. The purpose of this study was to develop and validate a clinical model for predicting high-risk coronary artery disease (CAD) ... Full text Link to item Cite

Female gender is associated with impaired quality of life 1 year after coronary artery bypass surgery.

Journal Article Psychosom Med · 2003 OBJECTIVE: To evaluate gender-related differences in quality of life (QOL) and cognitive function 1 year after coronary artery bypass surgery (CABG) after adjusting for known baseline differences. MATERIALS AND METHODS: Two hundred eighty patients (96 wome ... Full text Link to item Cite

Correlations between preprocedure mood and clinical outcome in patients undergoing coronary angioplasty.

Journal Article Cardiol Rev · 2003 We studied the relationship between mood and mood shift immediately before percutaneous coronary intervention (PCI) and 3 end points: total ischemic burden during PCI, adverse cardiac end points (ACE) after PCI, and death by 6-month follow up. Patients (n ... Full text Link to item Cite

Time-based risk assessment after myocardial infarction. Implications for timing of discharge and applications to medical decision-making.

Journal Article Eur Heart J · January 2003 AIMS: We evaluated timing of adverse cardiac events after thrombolysis to guide length of stay after ST-segment elevation myocardial infarction. METHODS AND RESULTS: Kaplan-Meier survival curves described timing of major postinfarction complications in 410 ... Full text Link to item Cite

A national survey of provisions in clinical-trial agreements between medical schools and industry sponsors.

Journal Article N Engl J Med · October 24, 2002 BACKGROUND: Concerned about threats to the integrity of clinical trials in a research environment increasingly controlled by private interests, the International Committee of Medical Journal Editors (ICMJE) has issued revised guidelines for investigators' ... Full text Link to item Cite

Intracoronary brachytherapy: time to sell short?

Journal Article Circulation · August 6, 2002 Full text Link to item Cite

Serum creatinine patterns in coronary bypass surgery patients with and without postoperative cognitive dysfunction.

Other Anesth Analg · July 2002 UNLABELLED: Renal dysfunction is common after coronary artery bypass graft (CABG) surgery. We have previously shown that CABG procedures complicated by stroke have a threefold greater peak serum creatinine level relative to uncomplicated surgery. However, ... Full text Link to item Cite

Vasopeptidase inhibitor reduces inhospital costs for patients with congestive heart failure: results from the IMPRESS trial. Inhibition of Metallo Protease by BMS-186716 in a Randomized Exercise and Symptoms Study in Subjects With Heart Failure.

Journal Article Am Heart J · June 2002 BACKGROUND: The Inhibition of Metallo Protease by BMS-186716 in a Randomized Exercise and Symptoms Study in Subjects With Heart Failure (IMPRESS) clinical trial randomized patients with congestive heart failure to a daily regimen of either omapatrilat or l ... Full text Link to item Cite

Glycoprotein IIb-IIIa inhibition with abciximab and postprocedural risk assessment: lessons from the evaluation of platelet IIb/IIIa inhibitor for stenting trial and implication for ad hoc use of glycoprotein IIb-IIIa antagonists.

Journal Article Am Heart J · April 2002 BACKGROUND: Angiographic features of vessels in which stents have been deployed can be used to predict the risk of postprocedural ischemic events. The purpose of this study was to compare the effects of abciximab in patients with and without high-risk post ... Full text Link to item Cite

Obesity and long-term clinical and economic outcomes in coronary artery disease patients.

Journal Article Obes Res · February 2002 OBJECTIVE: Obesity is an important risk factor for coronary artery disease (CAD); however, its effect on acute coronary syndrome (ACS) patients' long-term clinical and economic outcomes has not been quantified. We assessed the impact of increasing body mas ... Full text Link to item Cite

Usefulness of psychosocial treatment of mental stress-induced myocardial ischemia in men.

Journal Article Am J Cardiol · January 15, 2002 This study examined the effects of exercise and stress management training on clinical outcomes and medical expenditures over a 5-year follow-up period in 94 male patients with established coronary artery disease (CAD) and evidence of ambulatory or mental ... Full text Link to item Cite

Predictors of smoking cessation in patients with a diagnosis of coronary artery disease.

Journal Article J Cardiopulm Rehabil · 2002 PURPOSE: This study aimed to examine demographic, psychosocial, and clinical variables as predictors of smoking cessation in patients with coronary artery disease. METHODS: Smoking status and psychosocial variables were obtained at baseline. Participants w ... Full text Link to item Cite

Variability in cost of coronary bypass surgery in New York State: potential for cost savings.

Journal Article Am Heart J · January 2002 OBJECTIVE: Previous analyses of variability in bypass resource use have not focused on hospital-level variation or adequately explored the influence of patient risk. We combined a clinical database with claims data to fully characterize patient level and h ... Full text Link to item Cite

Report of the substudy assessing the impact of neurocognitive function on quality of life 5 years after cardiac surgery.

Journal Article Stroke · December 1, 2001 BACKGROUND AND PURPOSE: The importance of perioperative cognitive decline has long been debated. We recently demonstrated a significant correlation between perioperative cognitive decline and long-term cognitive dysfunction. Despite this association, some ... Full text Link to item Cite

Advanced coronary artery disease: Appropriate end points for trials of novel therapies.

Journal Article Am Heart J · November 2001 BACKGROUND: The segment of patients with advanced coronary artery disease, or disease that is not amenable to conventional revascularization therapies, continues to grow. Because the natural history of these patients is less defined, the appropriate end po ... Full text Link to item Cite

Prospective randomized trial of normothermic versus hypothermic cardiopulmonary bypass on cognitive function after coronary artery bypass graft surgery.

Journal Article Anesthesiology · November 2001 BACKGROUND: Despite significant advances in cardiopulmonary bypass (CPB) technology, surgical techniques, and anesthetic management, central nervous system complications occur in a large percentage of patients undergoing surgery requiring CPB. Many centers ... Full text Link to item Cite

Severity of renal vascular disease predicts mortality in patients undergoing coronary angiography.

Journal Article Kidney Int · October 2001 BACKGROUND: Renal artery stenosis (RAS) is a relatively uncommon but potentially reversible cause of renal failure. In a previous report, we demonstrated that the presence of RAS is independently associated with mortality in a group of patients undergoing ... Full text Link to item Cite

Using observational data to estimate prognosis: an example using a coronary artery disease registry.

Journal Article Stat Med · August 30, 2001 With the proliferation of clinical data registries and the rising expense of clinical trials, observational data sources are increasingly providing evidence for clinical decision making. These data are viewed as complementary to randomized clinical trials ... Full text Link to item Cite

Assessing the clinical and economic burden of coronary artery disease: 1986-1998.

Journal Article Med Care · August 2001 BACKGROUND: The acute phase of coronary artery disease (CAD) is dramatic and receives much attention because of its high mortality and associated treatment cost. However, the acute phase typically resolves within 30 days whereas CAD is a chronic disease, w ... Full text Link to item Cite

Outcomes of noncardiac surgery after coronary bypass surgery or coronary angioplasty in the Bypass Angioplasty Revascularization Investigation (BARI).

Journal Article Am J Med · March 2001 PURPOSE: Previous studies have shown that coronary artery bypass surgery reduces the risk of cardiac complications after noncardiac surgery. Whether coronary angioplasty provides equivalent protection is not known. SUBJECTS AND METHODS: Patients were rando ... Full text Link to item Cite

Risk stratification in patients with chest pain.

Journal Article Prim Care · March 2001 This article reviews the role of exercise testing in the assessment of patients with suspected coronary disease. To accomplish this, four major topics are considered: the general concept of risk stratification; the estimation of outcomes using data from th ... Full text Link to item Cite

Longitudinal assessment of neurocognitive function after coronary-artery bypass surgery.

Journal Article N Engl J Med · February 8, 2001 BACKGROUND: Cognitive decline complicates early recovery after coronary-artery bypass grafting (CABG) and may be evident in as many as three quarters of patients at the time of discharge from the hospital and a third of patients after six months. We sought ... Full text Link to item Cite

Personality and coping with a common stressor: cardiac catheterization.

Journal Article J Behav Med · February 2001 The association between coping and personality was examined in a sample of 204 cardiac catheterization patients who were asked to evaluate the use of specific coping strategies used to deal with their cardiac catheterization. Personality, as measured by th ... Full text Link to item Cite

Enhancing Recovery in Coronary Heart Disease (ENRICHD) study intervention: rationale and design.

Journal Article Psychosom Med · 2001 OBJECTIVE: Depression and low social support are risk factors for medical morbidity and mortality after acute MI. The ENRICHD study is a multicenter, randomized, controlled clinical trial of a cognitive-behavioral treatment for depression and low social su ... Link to item Cite

Temperature during coronary artery bypass surgery affects quality of life.

Journal Article Ann Thorac Surg · January 2001 BACKGROUND: The objective of this study was to examine the effects of temperature on a variety of indices of psychologic adjustment and quality of life. METHODS: A total of 209 patients randomly received normothermic (warm) or hypothermic (cold) conditions ... Full text Link to item Cite

Characteristics of socially isolated patients with coronary artery disease who are at elevated risk for mortality.

Journal Article Psychosom Med · 2001 OBJECTIVES: Social isolation has been linked to poor survival in patients with coronary artery disease (CAD). Few studies have closely examined the psychosocial characteristics of CAD patients who lack social contact. METHODS: Social isolation was examined ... Full text Link to item Cite

Economic assessment of platelet glycoprotein IIb/IIIa receptor blockade with abciximab and low-dose heparin during percutaneous coronary revascularization: results from the EPILOG randomized trial. Evaluation in PTCA to Improve Long-term Outcome with abciximab GP IIb/IIIa blockade.

Journal Article Circulation · December 12, 2000 BACKGROUND: In the EPILOG trial (Evaluation in PTCA to Improve Long-term Outcome with abciximab GP IIb/IIIa blockade), abciximab administered with weight-adjusted heparin diminished the risk of ischemic complications within 30 days by 56% among patients un ... Full text Link to item Cite

Temporal evolution in the management of acute ST elevation myocardial infarction: The seven-year GUSTO experience from Canada and the United States

Journal Article Canadian Journal of Cardiology · December 12, 2000 Background: Temporal changes in baseline characteristics, treatment and clinical outcomes of patients presenting with acute ST elevation myocardial infarction in Canada and the United States have not been examined comprehensively over time. Objectives: To ... Cite

Temporal evolution in the management of acute ST elevation myocardial infarction: the seven-year GUSTO experience from canada and the united states. The North American GUSTO-I and GUSTO-III investigators.

Journal Article Can J Cardiol · October 2000 BACKGROUND: Temporal changes in baseline characteristics, treatment and clinical outcomes of patients presenting with acute ST elevation myocardial infarction in Canada and the United States have not been examined comprehensively over time. OBJECTIVES: To ... Link to item Cite

Canadian-American differences in the management of acute coronary syndromes in the GUSTO IIb trial: one-year follow-up of patients without ST-segment elevation. Global Use of Strategies to Open Occluded Coronary Arteries (GUSTO) II Investigators.

Journal Article Circulation · September 19, 2000 BACKGROUND: Little information exists concerning practice patterns between Canada and the United States in the management of myocardial infarction (MI) patients without ST-segment elevation and unstable angina. METHODS AND RESULTS: We examined the practice ... Full text Link to item Cite

Moderators of the effect of social support on depressive symptoms in cardiac patients.

Journal Article Am J Cardiol · August 15, 2000 Social support and depression have been shown to affect the prognosis of coronary patients, and social support has been found to influence depression in community and patient samples. We investigated the characteristics of coronary patients whose depressiv ... Full text Link to item Cite

Use of resources, quality of life, and clinical outcomes in patients with and without new Q waves after thrombolytic therapy for acute myocardial infarction (from the GUSTO-I trial).

Journal Article Am J Cardiol · July 1, 2000 Previous reports indicate that patients who do not develop Q waves after thrombolytic therapy are a different population with a better long-term survival than those who do develop Q waves. However, the use of resources, quality of life, and health status o ... Full text Link to item Cite

Importance of on-site catheterization facilities in the cost saving potential of GPIIb/IIIa inhibitors for acute coronary syndrome: Results from PURSUIT

Journal Article Heart · June 1, 2000 Background: To examine the effect of on-site cardiac catheterization facilities (CC) on the medical care costs and resource use in the PURSUIT trial in Western Europe (WE) and the USA. Methods: Hospitals participating in the PURSUIT trial were sorted based ... Cite

Economic end points in phase II trials.

Journal Article Am Heart J · April 2000 Full text Link to item Cite

Cost effectiveness of early discharge after uncomplicated acute myocardial infarction.

Journal Article N Engl J Med · March 16, 2000 BACKGROUND: Reducing the length of hospitalizations can reduce short-term costs, but there are few data on the long-term clinical and economic consequences of early discharge. METHODS: Using data from the Global Utilization of Streptokinase and Tissue Plas ... Full text Link to item Cite

Quality of life after coronary revascularization in the United States and Canada.

Journal Article Am J Cardiol · March 1, 2000 Cardiac procedures are performed less frequently in Canada than in the United States (US), yet rates of cardiac death and myocardial infarction are similar. We therefore sought to compare long-term symptoms and quality of life in Canadian and American pati ... Full text Link to item Cite

Evaluating the potential 'economic attractiveness' of new therapies in patients with non-ST elevation acute coronary syndrome.

Journal Article Pharmacoeconomics · March 2000 OBJECTIVE: To evaluate the relationship between how much a new cardiovascular therapy improves clinical outcomes over current therapies and how much more it can cost while still remaining 'economically attractive'. DESIGN: We developed a decision model to ... Full text Link to item Cite

Cost-effectiveness of platelet glycoprotein IIb/IIIa inhibition with eptifibatide in patients with non-ST-elevation acute coronary syndromes.

Journal Article Circulation · February 1, 2000 BACKGROUND: In the PURSUIT trial, eptifibatide significantly reduced the 30-day incidence of death and myocardial infarction relative to placebo in 9461 patients with an acute coronary syndrome (unstable angina or non-Q-wave myocardial infarction). METHODS ... Full text Link to item Cite

Comparison of sibrafiban with aspirin for prevention of cardiovascular events after acute coronary syndromes: a randomised trial. The SYMPHONY Investigators. Sibrafiban versus Aspirin to Yield Maximum Protection from Ischemic Heart Events Post-acute Coronary Syndromes.

Journal Article Lancet · January 29, 2000 BACKGROUND: Aspirin lowers risks of death and myocardial infarction in patients with acute coronary syndromes. Intravenous glycoprotein IIb/IIIa receptor antagonists further reduce the rates of ischaemic events in these patients, but the efficacy of long-t ... Link to item Cite

Coronary catherization patient and wife's perceptions of social support: effects due to characteristics of recipient, provider, and their interaction.

Journal Article Int J Aging Hum Dev · 2000 This investigation explored relationships between coronary catherization patient and wife's characteristics and their perceptions of social support. Participants were 124 male patients undergoing diagnostic catherization to detect coronary artery disease ( ... Full text Link to item Cite

Depressive symptoms and survival of patients with coronary artery disease.

Journal Article Psychosom Med · 2000 OBJECTIVE: Multiple studies have shown that high levels of depressive symptoms increase the mortality risk of patients with established coronary disease. This investigation divided depressive symptoms into groups to assess their relative effectiveness in p ... Full text Link to item Cite

Social support and quality of life in patients with coronary artery disease.

Journal Article Qual Life Res · 2000 The relationship between perceived social support and domain-specific health-related quality of life (HRQOL) was examined in a sample of cardiac catheterization patients after considering age, gender, race, education, and coronary artery disease (CAD) seve ... Full text Link to item Cite

Outcomes at 1 year and economic implications of platelet glycoprotein IIb/IIIa blockade in patients undergoing coronary stenting: results from a multicentre randomised trial. EPISTENT Investigators. Evaluation of Platelet IIb/IIIa Inhibitor for Stenting.

Journal Article Lancet · December 11, 1999 BACKGROUND: We assessed in a randomised trial the long-term outcomes for potent adjunctive antiplatelet therapy given at the time of coronary stenting. METHODS: In 63 hospitals in the USA and Canada, 2399 patients were randomly assigned stenting with abcix ... Full text Link to item Cite

Cost estimates for treatment of cardiac ischemia (from the Asymptomatic Cardiac Ischemia Pilot [ACIP] study).

Journal Article Am J Cardiol · December 1, 1999 Costs for management of myocardial ischemia are enormous, yet comparison cost and outcome data for various ischemia treatment strategies from randomized trials are lacking and will require cost and resource utilization data from a large prospective trial. ... Full text Link to item Cite

The association between self-rated health and mortality in a well-characterized sample of coronary artery disease patients.

Journal Article Med Care · December 1999 BACKGROUND: The relationship between self-rated health and mortality after adjustment for sociodemographic variables, physician-rated comorbidities, disease severity, health-related quality of life (HRQOL), and psychosocial measures (depression, social sup ... Full text Link to item Cite

The relationship between self-rated health and health status among coronary artery patients.

Journal Article J Aging Health · November 1999 OBJECTIVES: This study examined the descriptive relationship of self-rated health (SRH) with various psychosocial measures, sociodemographic variables, coronary artery disease (CAD) diagnostic/clinical measures, and medically abstracted comorbidities. METH ... Full text Link to item Cite

Clinical correlates of the initial and long-term cost of coronary bypass surgery and coronary angioplasty.

Journal Article Am Heart J · August 1999 BACKGROUND: Medical costs vary substantially among patients. Understanding the baseline factors that predict subsequent cost may allow better selection of therapy for individual patients. Understanding the postprocedure events that increase cost should hel ... Full text Link to item Cite

A comparison of U.S. and Canadian cardiac catheterization practices in detecting severe coronary artery disease after myocardial infarction: efficiency, yield and long-term implications.

Journal Article J Am Coll Cardiol · July 1999 OBJECTIVES: We sought to compare U.S. and Canada's post-myocardial infarction (MI) cardiac catheterization practices in the detection of severe coronary artery disease (CAD). BACKGROUND: Little is known about the efficiency with which the aggressive post-M ... Full text Link to item Cite

Acute and long-term cost implications of coronary stenting.

Journal Article J Am Coll Cardiol · May 1999 OBJECTIVES: We compared the acute and one year medical costs and outcomes of coronary stenting with those for balloon angioplasty (percutaneous transluminal coronary angioplasty) in contemporary clinical practice. BACKGROUND: While coronary stent implantat ... Full text Link to item Cite

Perception of cognitive function in older adults following coronary artery bypass surgery.

Journal Article Health Psychol · May 1999 This study examined the effects of coronary artery bypass grafting (CABG) on objective and subjective measures of neurocognitive functioning. Participants were 170 older patients (127 men and 43 women; mean age = 61 years) undergoing CABG. Measures of neur ... Full text Link to item Cite

Effects of stroke on medical resource use and costs in acute myocardial infarction. GUSTO I Investigators. Global Utilization of Streptokinase and Tissue Plasminogen Activator for Occluded Coronary Arteries Study.

Journal Article Circulation · January 26, 1999 BACKGROUND: Stroke occurs concurrently with myocardial infarction (MI) in approximately 30 000 US patients each year. This number is expected to rise with the increasing use of thrombolytic therapy for MI. However, no data exist for the economic effect of ... Full text Link to item Cite

Dealing with success at the American Heart Journal

Journal Article American Heart Journal · January 1, 1999 Full text Cite

The chest-pain unit--ready for prime time?

Journal Article N Engl J Med · December 24, 1998 Full text Link to item Cite

Value of exercise treadmill testing in women.

Journal Article J Am Coll Cardiol · November 15, 1998 OBJECTIVES: We sought to determine the ability of a treadmill score to provide accurate diagnostic and prognostic risk estimates in women. BACKGROUND: Treadmill testing has been reported to have a lower accuracy for diagnosis of chest pain in women. The di ... Full text Link to item Cite

Use of a prognostic treadmill score in identifying diagnostic coronary disease subgroups.

Journal Article Circulation · October 20, 1998 BACKGROUND: Exercise testing is useful in the assessment of symptomatic patients for diagnosis of significant or extensive coronary disease and to predict their future risk of cardiac events. The Duke treadmill score (DTS) is a composite index that was des ... Full text Link to item Cite

Employment after coronary angioplasty or coronary bypass surgery in patients employed at the time of revascularization.

Journal Article Ann Intern Med · October 1, 1998 BACKGROUND: Patients who undergo coronary angioplasty have a shorter convalescence than those who undergo coronary bypass surgery. This may improve subsequent employment. OBJECTIVE: To compare employment patterns after coronary angioplasty or surgery. DESI ... Full text Link to item Cite

The effects of New York's bypass surgery provider profiling on access to care and patient outcomes in the elderly.

Journal Article J Am Coll Cardiol · October 1998 OBJECTIVE: The aim of this study was to examine the effects of provider profiling on bypass surgery access and outcomes in elderly patients in New York. BACKGROUND: Since 1989, New York (NY) has compiled provider-specific bypass surgery mortality reports. ... Full text Link to item Cite

When innovative therapies make economic sense: economic analysis of enoxaparin versus unfractionated heparin in the ESSENCE trial--an overview. Efficacy and Safety of Subcutaneous in non-Q Wave Coronary Events.

Journal Article Can J Cardiol · August 1998 An economic substudy using intention-to-treat analysis was conducted prospectively to compare the costs of enoxaparin and unfractionated heparin (UFH) therapy in 936 patients enrolled in the United States arm of the multicentre, international Efficacy and ... Link to item Cite

Economic assessment of low-molecular-weight heparin (enoxaparin) versus unfractionated heparin in acute coronary syndrome patients: results from the ESSENCE randomized trial. Efficacy and Safety of Subcutaneous Enoxaparin in Non-Q wave Coronary Events [unstable angina or non-Q-wave myocardial infarction].

Journal Article Circulation · May 5, 1998 BACKGROUND: In the ESSENCE trial, subcutaneous low-molecular-weight heparin (enoxaparin) reduced the 30-day incidence of death, myocardial infarction, and recurrent angina relative to intravenous unfractionated heparin in 3171 patients with acute coronary ... Full text Link to item Cite

Survival in renal vascular disease.

Journal Article J Am Soc Nephrol · February 1998 Renal artery stenosis (RAS) is a relatively uncommon but important potentially reversible cause of renal failure. Little is known about the natural history of ischemic renal disease secondary to RAS. In previous reports, these researchers examined the inci ... Full text Link to item Cite

Social support and hostility as predictors of depressive symptoms in cardiac patients one month after hospitalization: a prospective study.

Journal Article Psychosom Med · 1998 OBJECTIVE: Hospitalization for cardiac disease is associated with an increased risk for depression, which itself confers a poorer prognosis. Few prospective studies have examined the determinants of depression after hospitalization in cardiac patients, and ... Full text Link to item Cite

Health economics of acute coronary syndromes

Journal Article Journal of Thrombosis and Thrombolysis · January 1, 1998 Full text Cite

Cost effectiveness of inpatient initiation of antiarrhythmic therapy for supraventricular tachycardias.

Journal Article Am J Cardiol · December 15, 1997 This study assessed the cost effectiveness of inpatient antiarrhythmic therapy initiation for supraventricular tachycardias using a metaanalysis of proarrhythmic risk and a decision analysis that compared inpatient to outpatient therapy initiation. A MEDLI ... Full text Link to item Cite

Comparing risk-adjustment methods for provider profiling.

Journal Article Stat Med · December 15, 1997 Risk-adjustment and provider profiling have become common terms as the medical profession attempts to measure quality and assess value in health care. One of the areas of care most thoroughly developed in this regard is quality assessment for coronary arte ... Full text Link to item Cite

Cognitive function 5 years after randomization to coronary angioplasty or coronary artery bypass graft surgery.

Journal Article Circulation · November 4, 1997 BACKGROUND: Coronary bypass surgery often leads to short-term cognitive dysfunction, whereas coronary angioplasty does not. Perioperative cognitive dysfunction usually resolves, although a subgroup of surgical patients may continue to exhibit long-term cog ... Link to item Cite

Economics of treating heart failure.

Journal Article Am J Cardiol · October 30, 1997 Over 400,000 people in the United States are diagnosed with congestive heart failure (CHF) annually. The 3 major causes of acute cardiac hospitalizations in the United States--CHF, unstable angina, and acute myocardial infarction--all reflect a failure to ... Full text Link to item Cite

Relationship between diabetes mellitus and long-term survival after coronary bypass and angioplasty.

Journal Article Circulation · October 21, 1997 BACKGROUND: Recent subgroup analyses of randomized trials have suggested that percutaneous intervention in diabetic patients with multivessel disease results in higher mortality than coronary artery bypass graft surgery (CABG). We studied the relationship ... Full text Link to item Cite

Impact of early discharge after coronary artery bypass graft surgery on rates of hospital readmission and death. The Ischemic Heart Disease (IHD) Patient Outcomes Research Team (PORT) Investigators.

Journal Article J Am Coll Cardiol · October 1997 OBJECTIVES: This study examined the impact of early hospital discharge on short-term clinical outcomes of elderly patients treated with coronary artery bypass graft surgery (CABG) in the United States in 1992. BACKGROUND: Protocols that encourage earlier d ... Full text Link to item Cite

Electrocardiographic differentiation of the ST-segment depression of acute myocardial injury due to the left circumflex artery occlusion from that of myocardial ischemia of nonocclusive etiologies.

Journal Article Am J Cardiol · August 15, 1997 Lead distributions of peak ST-segment depression were compared between patients undergoing left circumflex artery percutaneous transluminal coronary angioplasty and exercise tolerance test. Localization of peak ST-segment depression to leads V2 or V3 was 9 ... Full text Link to item Cite

Relationship between physician and hospital coronary angioplasty volume and outcome in elderly patients.

Journal Article Circulation · June 3, 1997 BACKGROUND: With the expectation that physicians who perform larger numbers of coronary angioplasty procedures will have better outcomes, the American College of Cardiology/ American Heart Association guidelines recommend minimum physician volumes of 75 pr ... Full text Link to item Cite

Surrogate assessment of coronary artery disease patients' functional capacity.

Journal Article Soc Sci Med · May 1997 An investigation of the surrogate assessment of coronary artery disease (CAD) patients' functional capacity was conducted using 193 patient and surrogate rater dyads. Mean age of patients and surrogate raters were 60.4 and 54.4 years, respectively. Patient ... Full text Link to item Cite

Use of evidence-based medical therapy in patients undergoing percutaneous coronary revascularization in the United States, Europe, and Canada. Coronary Angioplasty Versus Excisional Atherectomy Trial (CAVEAT-I) and Canadian Coronary Atherectomy Trial (CCAT) investigators.

Journal Article Am J Cardiol · April 1, 1997 The objective of this study was to examine whether there are international variations in the use of evidence-based medical therapy in patients undergoing percutaneous coronary revascularization. We analyzed the medical therapy of patients in the United Sta ... Full text Link to item Cite

Geographic variation in resource use for coronary artery bypass surgery. IHD Port Investigators.

Journal Article Med Care · April 1997 OBJECTIVES: The purpose of this study was to examine the national variability in patient-level cost and length of stay for coronary artery bypass grafting (CABG) in Medicare patients. METHODS: Retrospective multivariate regression analysis was done using M ... Full text Link to item Cite

Economic implications of the prophylactic use of intraaortic balloon counterpulsation in the setting of acute myocardial infarction. The Randomized IABP Study Group. Intraaortic Balloon Pump.

Journal Article Am J Cardiol · March 1, 1997 Intraaortic balloon counterpulsation (IABP) has been shown to improve coronary artery patency and reduce the rates of recurrent myocardial ischemia and its sequelae in selected patients when used within 24 hours of acute myocardial infarction. The economic ... Full text Link to item Cite

Racial variation in the use of coronary-revascularization procedures. Are the differences real? Do they matter?

Journal Article N Engl J Med · February 13, 1997 BACKGROUND: Studies have reported that blacks undergo fewer coronary-revascularization procedures than whites, but it is not clear whether the clinical characteristics of the patients account for these differences or whether they indicate underuse of the p ... Full text Link to item Cite

Medical care costs and quality of life after randomization to coronary angioplasty or coronary bypass surgery. Bypass Angioplasty Revascularization Investigation (BARI) Investigators.

Journal Article N Engl J Med · January 9, 1997 BACKGROUND: Randomized trials comparing coronary angioplasty with bypass surgery in patients with multivessel coronary disease have shown no significant differences in overall rates of death and myocardial infarction. We compared quality of life, employmen ... Full text Link to item Cite

Our vision for the American Heart Journal.

Journal Article Am Heart J · January 1997 Full text Link to item Cite

Assessing the value of newer pharmacologic agents in non-ST elevation patients: a decision support system application.

Journal Article Proc AMIA Annu Fall Symp · 1997 Newer pharmacologic agents have demonstrated significant clinical and economic benefit in high-risk percutaneous transluminal coronary angioplasty (PTCA) patients. However, the higher costs of these agents may prohibit their use in lower-risk coronary arte ... Link to item Cite

Lessons for the editors

Journal Article American Heart Journal · January 1, 1997 Full text Cite

Assessing the Value of Newer Pharmacologic Agents in Non-ST Elevation Patients: A Decision Support System Application

Journal Article Journal of the American Medical Informatics Association · January 1, 1997 Newer pharmacologic agents have demonstrated significant clinical and economic benefit in high-risk percutaneous transluminal coronary angioplasty (PTCA) patients. However, the higher costs of these agents may prohibit their use in lower-risk coronary arte ... Cite

Outcome of acute myocardial infarction according to the specialty of the admitting physician.

Journal Article N Engl J Med · December 19, 1996 BACKGROUND: In order to limit costs, health care organizations in the United States are shifting medical care from specialists to primary care physicians. Although primary care physicians provide less resource-intensive care, there is little information co ... Full text Link to item Cite

Stent implantation reduced repeat angioplasty at 1 year in patients with stable angina

Journal Article Evidence-Based Medicine · December 1, 1996 Continued beliefit of coronmy stenting versus balloon augioplasty: one-year clinical follow-up ofBenestent trial. ... Cite

Depression and long-term mortality risk in patients with coronary artery disease.

Journal Article Am J Cardiol · September 15, 1996 Previous research has established that patients with coronary artery disease (CAD) have an increased risk of death if they are depressed at the time of hospitalization. Follow-up periods have been short in these studies; therefore, the present investigatio ... Full text Link to item Cite

Coronary artery stents. American College of Cardiology.

Journal Article J Am Coll Cardiol · September 1996 Link to item Cite

Economic assessment of platelet glycoprotein IIb/IIIa inhibition for prevention of ischemic complications of high-risk coronary angioplasty. EPIC Investigators.

Journal Article Circulation · August 15, 1996 BACKGROUND: In the EPIC trial, c7E3 Fab, an antiplatelet IIb/ IIIa receptor antibody, reduced 30-day ischemic end points after high-risk coronary angioplasty by 35% and 6-month ischemic events by 23% but increased in-hospital bleeding episodes. METHODS AND ... Full text Link to item Cite

Impact of an interactive video on decision making of patients with ischemic heart disease.

Journal Article J Gen Intern Med · June 1996 An experimental pilot study using repeated measures to examine the impact of an interactive video program on the decision making of patients with ischemic heart disease was carried on at a tertiary care center and a Veterans Affairs hospital. The patients ... Full text Link to item Cite

Long-term survival benefits of coronary artery bypass grafting and percutaneous transluminal angioplasty in patients with coronary artery disease.

Journal Article J Thorac Cardiovasc Surg · May 1996 The purpose of this study was to evaluate long-term survival benefits of bypass surgery and angioplasty versus medical therapy in 9263 patients at Duke University Medical Center between 1984 and 1990 with coronary artery disease confirmed by cardiac cathet ... Full text Link to item Cite

Early discharge in the thrombolytic era: an analysis of criteria for uncomplicated infarction from the Global Utilization of Streptokinase and t-PA for Occluded Coronary Arteries (GUSTO) trial.

Journal Article J Am Coll Cardiol · March 1, 1996 OBJECTIVES: This study sought to readdress the definition of uncomplicated myocardial infarction and to apply clinical criteria for early discharge of such patients in the thrombolytic era. BACKGROUND: Previous studies proposed early hospital discharge at ... Full text Link to item Cite

Multivariable prognostic models: issues in developing models, evaluating assumptions and adequacy, and measuring and reducing errors.

Journal Article Stat Med · February 28, 1996 Multivariable regression models are powerful tools that are used frequently in studies of clinical outcomes. These models can use a mixture of categorical and continuous variables and can handle partially observed (censored) responses. However, uncritical ... Full text Link to item Cite

Implications of cost in treatment selection for patients with coronary heart disease.

Journal Article Ann Thorac Surg · February 1996 BACKGROUND: The growth of managed care and other types of capitated payment systems for medical care has forced cost into the therapeutic equation. The benefits of treatment must now be balanced against their costs. Clinicians are being challenged to prove ... Full text Link to item Cite

Economics and Quality of Life After Acute Myocardial Infarction: Insights from GUSTO-I.

Journal Article J Thromb Thrombolysis · 1996 Reperfusion therapy for acute myocardial infarction is one of the most thoroughly studied treatments in all of medicine. The GISSI-1 and ISIS-2 megatrials definitively established the superiority of intravenous streptokinase over conservative care for this ... Full text Link to item Cite

The way of the future redux.

Journal Article Am J Cardiol · December 1, 1995 Full text Link to item Cite

Frequency, significance, and cost of recurrent ischemia after thrombolytic therapy for acute myocardial infarction. TAMI Study Group.

Journal Article Am J Cardiol · November 15, 1995 Early postinfarction angina implies an unfavorable prognosis. Most published information on this outcome represents data collected in the prethrombolytic era, in which definitions and populations differed considerably. Our purpose was to evaluate the incid ... Full text Link to item Cite

Better functional status in American than Canadian patients with heart disease: an effect of medical care?

Journal Article J Am Coll Cardiol · November 1, 1995 OBJECTIVES: This study compared functional status in Americans and Canadians with and without prior symptoms of heart disease to separate the effects of medical care from nonmedical factors. BACKGROUND: Coronary angiography and revascularization are used m ... Full text Link to item Cite

Outcomes of coronary artery bypass graft surgery in 24,461 patients aged 80 years or older.

Journal Article Circulation · November 1, 1995 BACKGROUND: Coronary artery bypass graft surgery is increasingly common in patients of age > or = 80 years. Single-institution reviews have cited a wide range of mortality results after bypass surgery in this age group, in part because of limited sample si ... Full text Link to item Cite

Peripheral vascular complications in the Coronary Angioplasty Versus Excisional Atherectomy Trial (CAVEAT-I).

Journal Article J Am Coll Cardiol · October 1995 OBJECTIVES: In-hospital peripheral vascular complications of balloon angioplasty were compared with those of directional atherectomy in the Coronary Angioplasty Versus Excisional Atherectomy Trial (CAVEAT-I) to identify patients at risk and evaluate costs ... Full text Link to item Cite

Baseline and 6-month costs of primary angioplasty therapy for acute myocardial infarction: results from the primary angioplasty registry.

Journal Article J Am Coll Cardiol · September 1995 OBJECTIVES: This study sought to describe the economic outcomes from a prospective multicenter registry of primary coronary angioplasty. BACKGROUND: Interest in coronary angioplasty without preceding thrombolytic therapy as a primary reperfusion strategy h ... Full text Link to item Cite

Regional variation across the United States in the management of acute myocardial infarction. GUSTO-1 Investigators. Global Utilization of Streptokinase and Tissue Plasminogen Activator for Occluded Coronary Arteries.

Journal Article N Engl J Med · August 31, 1995 BACKGROUND: Differences in the management of acute myocardial infarction have been reported among countries, but few studies have investigated this issue in regions of the United States. METHODS: We compared the management of acute myocardial infarction am ... Full text Link to item Cite

Diagnosing and managing unstable angina: Quick reference guide for clinicians

Journal Article Journal of Geriatric Drug Therapy · August 28, 1995 This Quick Reference Guide for Clinicians contains recommendations on the care of patients with unstable angina based on a combination of evidence obtained through extensive literature reviews and consensus among members of a private-sector, expert panel. ... Full text Cite

Are PRO discharge screens associated with postdischarge adverse outcomes?

Journal Article Health Serv Res · August 1995 OBJECTIVE: We evaluate whether patient outcomes may be affected by possible errors in care at discharge as assessed by Peer Review Organizations (PROs). DATA SOURCES/STUDY SETTING: The three data sources for the study were (1) the generic screen results of ... Link to item Cite

Job strain and the prevalence and outcome of coronary artery disease.

Journal Article Circulation · August 1, 1995 BACKGROUND: It has been hypothesized that jobs that have both high psychological demands and low decision latitude ("job strain") can lead to coronary disease. The objective of this study was to test whether job strain was correlated with the presence of c ... Full text Link to item Cite

Importance of baseline functional and socioeconomic factors for participation in cardiac rehabilitation.

Journal Article Am J Cardiol · July 1, 1995 Enrollment in cardiac rehabilitation has been reported to improve exercise capacity, psychological well-being, and survival. However, participation rates are low and the reasons for nonparticipation have not been adequately defined. The purpose of this stu ... Full text Link to item Cite

Characteristics and consequences of myocardial infarction after percutaneous coronary intervention: insights from the Coronary Angioplasty Versus Excisional Atherectomy Trial (CAVEAT).

Journal Article J Am Coll Cardiol · June 1995 OBJECTIVES: We examined the results of the Coronary Angioplasty Versus Excisional Atherectomy Trial (CAVEAT) to determine the characteristics and consequences of creatine kinase (CK) and creatine kinase, MB myocardial isoenzyme fraction (CK-MB) elevations ... Full text Link to item Cite

Differences in the treatment of myocardial infarction between the United States and Canada. A survey of physicians in the GUSTO trial.

Journal Article Med Care · June 1995 Treatment of acute myocardial infarction differs between the United States and Canada, but the reasons for these practice pattern differences remain elusive. To investigate whether physician beliefs and access to procedures account for these differences in ... Full text Link to item Cite

Distinguishing between early and late responders to symptoms of acute myocardial infarction.

Journal Article Am J Cardiol · May 15, 1995 The present study identified factors that distinguish early responders (i.e., requested medical assistance < 60 minutes after the onset of acute myocardial infarction [AMI] symptoms) from late responders (i.e., request made > or = 60 minutes after symptom ... Full text Link to item Cite

Cost effectiveness of thrombolytic therapy with tissue plasminogen activator as compared with streptokinase for acute myocardial infarction.

Journal Article The New England journal of medicine · May 1995 BACKGROUND. Patients with acute myocardial infarction who were treated with accelerated tissue plasminogen activator (t-PA) (given over a period of 1 1/2 hours rather than the conventional 3 hours, and with two thirds of the dose given in the first 30 minu ... Cite

Initial functional and economic status of patients with multivessel coronary artery disease randomized in the Bypass Angioplasty Revascularization Investigation (BARI).

Journal Article Am J Cardiol · March 23, 1995 Randomized trials of coronary angioplasty and bypass surgery have hypothesized that these procedures will have equivalent long-term rates of death and myocardial infarction. Functional status, quality of life, employment, and healthcare cost will therefore ... Link to item Cite

Clinical and economic lessons from studies of coronary thrombolysis.

Journal Article J Vasc Interv Radiol · 1995 The era of coronary reperfusion in acute coronary care was made possible by the recognition that acute myocardial infarction is usually due to a ruptured atherosclerotic plaque with associated thrombosis. If the infarct artery becomes occluded, a typical e ... Full text Link to item Cite

CABG, PTCA or medical management? for Coronary artery disease

Journal Article Primary Cardiology · January 1, 1995 The use of percutaneous transluminal coronary angioplasty (PTCA), coronary artery bypass grafting (CABG), or medical therapy for treatment of coronary artery disease (CAD) continues to be evaluated in randomized clinical trials and through review of treatm ... Cite

The relation between the volume of coronary angioplasty procedures at hospitals treating Medicare beneficiaries and short-term mortality.

Journal Article N Engl J Med · December 15, 1994 BACKGROUND: Previous studies have found that hospitals at which more procedures, such as coronary-artery bypass grafting (CABG) and other vascular surgery, are performed have lower rates of mortality related to these procedures than hospitals where fewer s ... Full text Link to item Cite

Changes in mortality after myocardial revascularization in the elderly. The national Medicare experience.

Journal Article Ann Intern Med · December 15, 1994 OBJECTIVE: To examine secular changes in the use and outcome of percutaneous transluminal coronary angioplasty and cardiac bypass graft surgery in the elderly. DESIGN: A retrospective cohort study based on a longitudinal database created from the administr ... Full text Link to item Cite

Use of medical resources and quality of life after acute myocardial infarction in Canada and the United States.

Journal Article N Engl J Med · October 27, 1994 BACKGROUND: Much attention has been directed to the use of medical resources and to patients' outcomes in Canada as compared with the United States. We compared U.S. and Canadian patients with respect to their use of medical resources and their quality of ... Full text Link to item Cite

Risk stratification in patients with chest pain.

Journal Article Prim Care · September 1994 The evaluation of patients with chest pain and suspected coronary disease remains a challenge for primary care physicians. In this article, three major points are emphasized. First, making full use of the data collected during the initial encounter prior t ... Link to item Cite

Costs of interventional cardiac procedures.

Journal Article J Interv Cardiol · August 1994 Full text Link to item Cite

Diagnosing and managing unstable angina. Agency for Health Care Policy and Research.

Journal Article Circulation · July 1994 This Quick Reference Guide for Clinicians contains recommendations on the care of patients with unstable angina based on a combination of evidence obtained through extensive literature reviews and consensus among members of an expert panel. Principal concl ... Full text Link to item Cite

Diagnosing and managing unstable angina

Journal Article Circulation · July 1, 1994 This Quick Reference Guide for Clinicians contains recommendations on the care of patients with unstable angina based on a combination of evidence obtained through extensive literature reviews and consensus among members of an expert panel. Principal concl ... Cite

Continuing evolution of therapy for coronary artery disease. Initial results from the era of coronary angioplasty.

Journal Article Circulation · May 1994 BACKGROUND: Survival after coronary artery bypass graft surgery (CABG) and medical therapy in patients with coronary artery disease (CAD) has been studied in both randomized trials and observational treatment comparisons. Over the past decade, the use of c ... Full text Link to item Cite

Absence of sex bias in the referral of patients for cardiac catheterization.

Journal Article N Engl J Med · April 21, 1994 BACKGROUND: It has been suggested that women with clinical evidence of coronary artery disease are less often referred for cardiac catheterization than are men. To determine whether there is sex-related bias in referral for cardiac catheterization, we pros ... Full text Link to item Cite

Percutaneous intervention, surgery, and medical therapy: a perspective from the Duke Databank for Cardiovascular Diseases.

Journal Article Semin Thorac Cardiovasc Surg · April 1994 Myocardial revascularization improves survival rates and quality of life for patients with symptomatic ischemic heart disease. The less severe the anatomic disease, the smaller the benefit, particularly for survival. Patients with more severe anatomic dise ... Link to item Cite

An overview of risk assessment in coronary artery disease.

Journal Article Am J Cardiol · March 10, 1994 Risk assessment is a central activity in virtually all aspects of the examination and treatment of patients. Methods to standardize this process and improve its accuracy can only improve the quality of medical care. Since health care is undergoing reform i ... Full text Link to item Cite

Intracranial hemorrhage risk and new thrombolytic therapies in acute myocardial infarction.

Journal Article Am J Cardiol · March 1, 1994 Thrombolytic therapy for acute myocardial infarction (AMI) has reduced mortality at the expense of additional intracranial hemorrhages. To determine whether this trade-off has been optimized, a decision analysis was performed using pooled data to determine ... Full text Link to item Cite

Effects of coronary angioplasty, coronary bypass surgery, and medical therapy on employment in patients with coronary artery disease. A prospective comparison study.

Journal Article Ann Intern Med · January 15, 1994 OBJECTIVE: To compare return-to-work rates after coronary angioplasty, coronary bypass surgery, and medical therapy in patients with coronary disease. DESIGN: Prospective cohort study. SETTING: Tertiary care referral center. PATIENTS: Between March 1986 an ... Full text Link to item Cite

Pain coping strategies in patients referred for evaluation of angina pectoris

Journal Article Journal of Cardiopulmonary Rehabilitation · January 1, 1994 Purpose. This study was conducted to investigate the relationship of pain coping strategies to functional status, pain, psychological distress, and depression in 72 chronic angina patients referred for diagnostic coronary angiography. Methods. Each subject ... Full text Cite

Discordance of databases designed for claims payment versus clinical information systems. Implications for outcomes research.

Journal Article Ann Intern Med · October 15, 1993 OBJECTIVE: To determine the suitability of insurance claims information for use in clinical outcomes research in ischemic heart disease. DESIGN: Concordance study of two databases. SETTING: Tertiary care referral center. PATIENTS: A total of 12,937 consecu ... Full text Link to item Cite

A comparison of directional atherectomy with coronary angioplasty in patients with coronary artery disease. The CAVEAT Study Group.

Journal Article N Engl J Med · July 22, 1993 BACKGROUND: Directional coronary atherectomy is a new technique of coronary revascularization by which atherosclerotic plaque is excised and retrieved from target lesions. With respect to the rate of restenosis and clinical outcomes, it is not known how th ... Full text Link to item Cite

Comparison of analytic models for estimating the effect of clinical factors on the cost of coronary artery bypass graft surgery.

Journal Article J Clin Epidemiol · March 1993 The cost of treating disease depends on patient characteristics, but standard tools for analyzing the clinical predictors of cost have deficiencies. To explore whether survival analysis techniques might overcome some of these deficiencies in the analysis o ... Full text Link to item Cite

Value of the history and physical in identifying patients at increased risk for coronary artery disease.

Journal Article Ann Intern Med · January 15, 1993 OBJECTIVE: To determine whether information from the physician's initial evaluation of patients with suspected coronary artery disease predicts coronary anatomy at catheterization and 3-year survival. DESIGN: Prospective validation of regression model esti ... Full text Link to item Cite

Prognosis in cardiogenic shock after acute myocardial infarction in the interventional era.

Journal Article J Am Coll Cardiol · December 1992 OBJECTIVES: The purpose of this study is to describe the outcome in cardiogenic shock treated with aggressive reperfusion therapy and to identify factors predictive of in-hospital and long-term mortality. BACKGROUND: Cardiogenic shock is the most common ca ... Full text Link to item Cite

Identification of patients with coronary disease at high risk for loss of employment. A prospective validation study.

Journal Article Circulation · November 1992 BACKGROUND: Work disability is common in patients with coronary artery disease and adversely affects both economic well-being and quality of life. The purpose of this study was to construct a model to predict premature departure from the work force of pati ... Full text Link to item Cite

Observational comparison of event-free survival with medical and surgical therapy in patients with coronary artery disease. 20 years of follow-up.

Journal Article Circulation · November 1992 BACKGROUND: The purpose of this study was to describe the long-term event-free survival patterns of patients with significant coronary artery disease treated medically versus patterns of those treated surgically and to evaluate the factors associated with ... Link to item Cite

In Reply

Journal Article JAMA: The Journal of the American Medical Association · July 8, 1992 Full text Cite

Ergonovine maleate testing during cardiac catheterization: a 10-year perspective in 3,447 patients without significant coronary artery disease or Prinzmetal's variant angina.

Journal Article J Am Coll Cardiol · July 1992 The utility of ergonovine testing for coronary artery spasm was assessed in 3,447 patients with angiographically insignificant (less than 50% diameter stenosis) or no coronary artery disease. No patients clinically had Prinzmetal's variant angina. Overall, ... Full text Link to item Cite

Referral patterns for coronary artery disease treatment: gender bias or good clinical judgment?

Journal Article Ann Intern Med · May 15, 1992 OBJECTIVE: To determine whether a gender bias exists in referral for coronary bypass graft surgery among patients with catheterization-documented coronary artery disease. DESIGN: Historical cohort study (1969 to 1984). SETTING: A referral medical center. P ... Full text Link to item Cite

Prognostic importance of social and economic resources among medically treated patients with angiographically documented coronary artery disease.

Journal Article JAMA · January 22, 1992 OBJECTIVE: To evaluate the hypothesis that diminished social and economic resources impact adversely on cardiovascular mortality in patients with coronary artery disease. DESIGN: Inception cohort study of patients undergoing cardiac catheterization from 19 ... Link to item Cite

Predicting coronary disease from a treadmill exercise score

Journal Article Annals of Internal Medicine · January 1, 1992 Cite

Observational comparison of event-free survival with medical and surgical therapy in patients with coronary artery disease: 20 Years of follow-up

Journal Article Circulation · January 1, 1992 Background. The purpose of this study was to describe the long-term event-free survival patterns of patients with significant coronary artery disease treated medically versus patterns of those treated surgically and to evaluate the factors associated with ... Cite

Social and economic factors in patients with coronary disease [1]

Journal Article Journal of the American Medical Association · 1992 Full text Cite

Study compares survival rates for treatments of heart disease

Journal Article American Family Physician · January 1, 1992 Cite

Predicting coronary disease from a treadmill exercise score

Journal Article Annals of Internal Medicine · January 1, 1992 Cite

Determinants of early versus late cardiac death in patients undergoing coronary artery bypass graft surgery.

Journal Article Circulation · November 1991 Most analyses of risk factors affecting survival after coronary artery bypass graft surgery have not differentiated among factors that influence early and late survival. For this reason, a multiphase model was applied to survival data from 2,967 patients u ... Link to item Cite

Prognostic value of a treadmill exercise score in outpatients with suspected coronary artery disease.

Journal Article N Engl J Med · September 19, 1991 BACKGROUND: The treadmill exercise test identifies patients with different degrees of risk of death from cardiovascular events. We devised a prognostic score, based on the results of treadmill exercise testing, that accurately predicts outcome among inpati ... Full text Link to item Cite

Estimating the likelihood of severe coronary artery disease.

Journal Article Am J Med · May 1991 PURPOSE: To determine which clinical characteristics obtained by a physician during an initial clinical examination are important for estimating the likelihood of severe coronary artery disease, and to determine whether estimates based on these characteris ... Link to item Cite

Restenosis after coronary angioplasty: an overview.

Journal Article J Am Coll Cardiol · May 1991 Despite substantial basic and clinical efforts to address the problem of restenosis after percutaneous coronary intervention, effective preventive therapies have not yet been developed. Nevertheless, the accumulated information has provided much insight in ... Full text Link to item Cite

RESTENOSIS AFTER CORONARY ANGIOPLASTY - AN OVERVIEW

Journal Article JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY · May 1, 1991 Link to item Cite

Identification of acute myocardial infarction patients suitable for early hospital discharge after aggressive interventional therapy. Results from the Thrombolysis and Angioplasty in Acute Myocardial Infarction Registry.

Journal Article Circulation · April 1991 BACKGROUND: Very early (day 4) hospital discharge has recently been proposed for selected patients with acute myocardial infarction (MI). The purpose of this study was to determine the most useful factors for identifying acute MI patients treated with aggr ... Full text Link to item Cite

Pericardial effusion after intravenous recombinant tissue-type plasminogen activator for acute myocardial infarction.

Journal Article Am J Cardiol · March 1, 1991 The effect of thrombolytic therapy on the frequency, time course and sequelae of pericardial effusion after myocardial infarction are unknown. A prospective, serial, 2-dimensional echocardiographic study of patients with myocardial infarction who received ... Full text Link to item Cite

Usefulness of a pericardial friction rub after thrombolytic therapy during acute myocardial infarction in predicting amount of myocardial damage. The TAMI Study Group.

Journal Article Am J Cardiol · December 15, 1990 To evaluate the clinical incidence and outcomes of patients with pericarditis after thrombolytic therapy, 810 patients were prospectively studied during acute myocardial infarction (AMI). Pericarditis was defined as the presence of a pericardial friction r ... Full text Link to item Cite

Resource use and cost of initial coronary revascularization. Coronary angioplasty versus coronary bypass surgery.

Journal Article Circulation · November 1990 Although there is intense interest in the cost-saving potential of therapeutic alternatives, most studies have analyzed hospital charges rather than actual economic costs. To analyze cost differences rigorously, we studied 115 patients undergoing initial e ... Link to item Cite

Prognostic value of radionuclide angiography in medically treated patients with coronary artery disease. A comparison with clinical and catheterization variables.

Journal Article Circulation · November 1990 To evaluate the usefulness of multiple measures from rest and exercise radionuclide angiography (RNA) in predicting cardiovascular death and cardiovascular events (death or nonfatal myocardial infarction) and to assess the prognostic usefulness of the RNA ... Full text Link to item Cite

Stroke and acute myocardial infarction in the thrombolytic era: clinical correlates and long-term prognosis.

Journal Article J Am Coll Cardiol · September 1990 Thirteen (1.8%) of 708 patients with acute myocardial infarction treated with recombinant tissue-type plasminogen activator in the Thrombolysis and Angioplasty in Myocardial Infarction (TAMI) I, II and III trials developed a stroke. Four strokes were hemor ... Full text Link to item Cite

Cardiac rupture, mortality and the timing of thrombolytic therapy: a meta-analysis.

Journal Article J Am Coll Cardiol · August 1990 This study examined the relation between the risk of cardiac rupture and the timing of thrombolytic therapy for acute myocardial infarction. To test the hypothesis that cardiac rupture is prevented by early thrombolytic therapy but is promoted by late trea ... Full text Link to item Cite

Effect of Type A behavior on exercise test outcome in coronary artery disease.

Journal Article Am J Cardiol · July 15, 1990 The outcome of the diagnostic exercise test depends on such patient-related factors as age, maximum exercise heart rate, exercise time and severity of the underlying coronary artery disease (CAD). This study examined the hypothesis that type A behavior wou ... Full text Link to item Cite

Thrombotic and cardiovascular complications related to nonionic contrast media during cardiac catheterization: analysis of 8,517 patients.

Journal Article Am J Cardiol · June 15, 1990 The incidence of major complications associated with nonionic contrast media has not been defined in a large study. Accordingly, cardiovascular complications, especially thrombotic events, were prospectively evaluated in 8,517 consecutive patients undergoi ... Full text Link to item Cite

Feasibility and cost-saving potential of outpatient cardiac catheterization.

Journal Article J Am Coll Cardiol · February 1990 To determine the feasibility and cost-saving potential of substituting outpatient for inpatient cardiac catheterization, 986 consecutive procedures were studied at a large referral hospital. Patients were classified prospectively as to their eligibility fo ... Full text Link to item Cite

Clinical judgment and therapeutic decision making.

Journal Article J Am Coll Cardiol · January 1990 Clinical decision making is under increased scrutiny due to concerns about the cost and quality of medical care. Variability in physician decision making is common, in part because of deficiencies in the knowledge base, but also due to the difference in ph ... Full text Link to item Cite

Detection of restenosis after elective percutaneous transluminal coronary angioplasty using the exercise treadmill test.

Journal Article Am J Cardiol · January 1, 1990 To determine the value of a 6-month exercise treadmill test for detecting restenosis after elective percutaneous transluminal coronary angioplasty (PTCA), 303 consecutive patients with successful PTCA and without a recent myocardial infarction were studied ... Full text Link to item Cite

Resource use and cost of initial coronary revascularization: Coronary angioplasty versus coronary bypass surgery

Journal Article Circulation · 1990 Although there is intense interest in the cost-saving potential of therapeutic alternatives, most studies have analyzed hospital charges rather than actual economic costs. To analyze cost differences rigorously, we studied 115 patients undergoing initial e ... Cite

Resource use and cost of initial coronary revascularization: Coronary angioplasty versus coronary bypass surgery

Journal Article Circulation · January 1, 1990 Although there is intense interest in the cost-saving potential of therapeutic alternatives, most studies have analyzed hospital charges rather than actual economic costs. To analyze cost differences rigorously, we studied 115 patients undergoing initial e ... Cite

Bleeding during thrombolytic therapy for acute myocardial infarction: mechanisms and management.

Journal Article Ann Intern Med · December 15, 1989 Hemorrhage is the major adverse effect of thrombolytic therapy, but its incidence can be reduced by careful selection of patients and avoidance of unnecessary invasive procedures. More than 70% of bleeding episodes occur at vascular puncture sites. Hypofib ... Full text Link to item Cite

Exercise treadmill testing is a poor predictor of anatomic restenosis after angioplasty for acute myocardial infarction.

Journal Article Circulation · December 1989 This study evaluated whether an exercise treadmill test could predict restenosis in 289 patients 6 months after a successful emergency angioplasty of the infarct-related artery for acute myocardial infarction. After excluding those with interim interventio ... Full text Link to item Cite

Clinical correlates and prognostic significance of type A behavior and silent myocardial ischemia on the treadmill.

Journal Article Am J Cardiol · December 1, 1989 Type A patients with coronary artery disease (CAD) tend to ignore or underreport symptoms, especially during challenging tasks such as the treadmill exercise test. To determine whether type A CAD patients might be more likely than type B patients to have s ... Full text Link to item Cite

Painless exercise ST deviation on the treadmill: long-term prognosis.

Journal Article J Am Coll Cardiol · October 1989 To evaluate the clinical correlates and long-term prognostic significance of silent ischemia during exercise, 1,698 consecutive symptomatic patients with coronary artery disease who had both treadmill testing and cardiac catheterization were studied. These ... Full text Link to item Cite

A brief self-administered questionnaire to determine functional capacity (the Duke Activity Status Index).

Journal Article Am J Cardiol · September 15, 1989 To develop a brief, self-administered questionnaire that accurately measures functional capacity and assesses aspects of quality of life, 50 subjects undergoing exercise testing with measurement of peak oxygen uptake were studied. All subjects were questio ... Full text Link to item Cite

Clinical experience and predicting survival in coronary disease.

Journal Article Arch Intern Med · May 1989 To study the accuracy with which long-term prognosis can be predicted in patients with coronary artery disease, prognostic predictions obtained from a large, diverse sample of practicing cardiologists were compared with predictions from a multivariable sta ... Link to item Cite

The evolution of medical and surgical therapy for coronary artery disease. A 15-year perspective.

Journal Article JAMA · April 14, 1989 To elucidate the factors associated with improved survival following coronary artery bypass surgery, we studied 5809 patients receiving medical or surgical therapy for coronary artery disease. Three factors were associated with a significant surgical survi ... Link to item Cite

Prediction of early recurrent myocardial ischemia and coronary reocclusion after successful thrombolysis: a qualitative and quantitative angiographic study.

Journal Article Am J Cardiol · February 15, 1989 To determine the association of qualitative and quantitative measurements of the myocardial infarct-related coronary narrowing with subsequent recurrent ischemia/reocclusion after successful thrombolysis, 47 patients treated with high-dose (150 mg) tissue ... Full text Link to item Cite

Administration of thrombolytic therapy in the community hospital: established principles and unresolved issues.

Journal Article J Am Coll Cardiol · December 1988 In patients with acute myocardial infarction presenting to community hospitals, thrombolytic therapy should be initiated as rapidly as possible under the supervision of a physician. Paramedic or nurse-initiated pre-hospital therapy is currently investigati ... Full text Link to item Cite

Surgical survival benefits for coronary disease patients with left ventricular dysfunction.

Journal Article Circulation · September 1988 Controversy still exists about the proper selection of patients with coronary artery disease and left ventricular dysfunction for coronary bypass surgery. To examine this issue, we studied 710 patients with significant coronary artery disease and left vent ... Link to item Cite

Changing efficacy of coronary revascularization. Implications for patient selection.

Journal Article Circulation · September 1988 To evaluate the potential impact of patient selection for coronary artery bypass graft surgery on long-term survival, the outcomes of 5,809 consecutive patients with symptomatic coronary disease documented by angiography at Duke University Medical Center w ... Link to item Cite

Survival and cardiac event rates in the first year after emergency coronary angioplasty for acute myocardial infarction.

Journal Article J Am Coll Cardiol · June 1988 One year survival and event-free survival rates were analyzed in 342 patients with acute myocardial infarction who were consecutively enrolled in a treatment protocol of early intravenous thrombolytic therapy followed by emergency coronary angioplasty. Nin ... Full text Link to item Cite

Comparison of time domain and frequency domain variables from the signal-averaged electrocardiogram: a multivariable analysis.

Journal Article J Am Coll Cardiol · May 1988 The relative values of the unprocessed signal-averaged electrocardiogram (ECG) and time domain analysis and frequency domain analysis of the signal-averaged ECG were compared in 36 patients with sustained monomorphic ventricular tachycardia and a remote my ... Full text Link to item Cite

Failure of simple clinical measurements to predict perfusion status after intravenous thrombolysis.

Journal Article Ann Intern Med · May 1988 To determine whether coronary patency could be detected early during thrombolytic therapy, commonly used markers of perfusion were recorded in 386 patients with acute myocardial infarction treated with tissue plasminogen activator. Infarct artery angiograp ... Full text Link to item Cite

Late restenosis after emergent coronary angioplasty for acute myocardial infarction: comparison with elective coronary angioplasty.

Journal Article J Am Coll Cardiol · April 1988 The late restenosis rate after emergent percutaneous transluminal coronary angioplasty for acute myocardial infarction was assessed by performing outpatient follow-up cardiac catheterization in 79 (87%) of 91 consecutive patients who had been discharged fr ... Full text Link to item Cite

Helicopter transport of patients during acute myocardial infarction.

Journal Article Am J Cardiol · April 1, 1988 Initial experience with a regional system of emergency helicopter transport of patients with acute myocardial infarction (AMI) referred for emergent cardiac catheterization and percutaneous transluminal coronary angioplasty (PTCA) is described. Two hundred ... Full text Link to item Cite

Trends in physician management of uncomplicated acute myocardial infarction, 1970 to 1987.

Journal Article Am J Cardiol · March 1, 1988 To document current management of uncomplicated acute myocardial infarction (AMI), a national survey of 1,065 physicians was performed. Items from previous surveys in 1970 and 1979 were included to permit analysis of time trends in management. Median hospi ... Full text Link to item Cite

Adoption of thrombolytic therapy in the management of acute myocardial infarction.

Journal Article Am J Cardiol · March 1, 1988 A national survey of 1,065 physicians was carried out to document current use of thrombolytic therapy for acute myocardial infarction (AMI). In early 1987, thrombolytic therapy was used by 66% of respondents. Among those who used thrombolytic therapy, 92% ... Full text Link to item Cite

Comparison of predictions based on observational data with the results of randomized controlled clinical trials of coronary artery bypass surgery.

Journal Article J Am Coll Cardiol · February 1988 Clinical decisions are most secure when based on findings from several large randomized clinical trials, but relevant randomized trial data are often unavailable. Analyses using clinical data bases might provide useful information if statistical methods ca ... Full text Link to item Cite

Prognostic value of the simplified Selvester QRS score in patients with coronary artery disease.

Journal Article J Am Coll Cardiol · January 1988 The relation of the simplified Selvester QRS scoring system for the estimation of myocardial infarct size to survival was studied in 1,915 nonsurgically treated patients with documented coronary artery disease. Electrocardiograms (ECGs) were scored accordi ... Full text Link to item Cite

Importance of clinical measures of ischemia in the prognosis of patients with documented coronary artery disease.

Journal Article J Am Coll Cardiol · January 1988 To examine the value of clinical measures of ischemia for stratifying prognosis, 5,886 consecutive patients who had symptomatic significant (greater than or equal to 75% stenosis) coronary artery disease were studied. Using the Cox regression model in a ra ... Full text Link to item Cite

Coronary perfusion during acute myocardial infarction with a combined therapy of coronary angioplasty and high-dose intravenous streptokinase.

Journal Article Circulation · January 1988 Two hundred and sixteen patients with acute myocardial infarction were treated with immediate infusion of high-dose (1.5 million units) intravenous streptokinase followed by emergency coronary angioplasty. The infarct lesion was crossed and dilated in 99% ... Full text Link to item Cite

Using the exercise treadmill test to predict outcome in coronary artery disease

Journal Article Cardiology Board Review · January 1, 1988 To derive a new exercise treadmill score useful for stratifying prognosis, we studied 2,842 consecutive patients with angina who were referred for both treadmill testing and cardiac catheterization. Our score was derived by applying the Cox proportional ha ... Cite

Surgical survival benefits for coronary disease patients with left ventricular dysfunction

Journal Article Circulation · 1988 Controversy still exists about the proper selection of patients with coronary artery disease and left ventricular dysfunction for coronary bypass surgery. To examine this issue, we studied 710 patients with significant coronary artery disease and left vent ... Cite

Surgical survival benefits for coronary disease patients with left ventricular dysfunction

Journal Article Circulation · January 1, 1988 Controversy still exists about the proper selection of patients with coronary artery disease and left ventricular dysfunction for coronary bypass surgery. To examine this issue, we studied 710 patients with significant coronary artery disease and left vent ... Cite

Changing efficacy of coronary revascularization. Implications for patient selection

Journal Article Circulation · January 1, 1988 To evaluate the potential impact of patient selection for coronary artery bypass graft surgery on long-term survival, the outcomes of 5,809 consecutive patients with symptomatic coronary disease documented by angiography at Duke University Medical Center w ... Cite

The changing survival benefits of coronary revascularization over time.

Journal Article Circulation · November 1987 Previous comparisons of medical and surgical therapy for coronary artery disease were performed in the 1970s and may need to be updated to reflect current treatment efficacy. The purpose of this investigation was to determine the impact on long-term patien ... Link to item Cite

Outcome in suspected acute myocardial infarction with normal or minimally abnormal admission electrocardiographic findings.

Journal Article Am J Cardiol · October 1, 1987 Seven hundred seventy-five consecutive patients with symptoms suggestive of acute myocardial infarction (AMI) who were admitted to the cardiac care unit from the emergency room were studied; 107 had normal electrocardiographic findings and 73 had only mini ... Full text Link to item Cite

Exercise treadmill score for predicting prognosis in coronary artery disease.

Journal Article Ann Intern Med · June 1987 To determine the prognostic value of the treadmill exercise test, we evaluated 2842 consecutive patients with chest pain who had both treadmill testing cardiac catheterization. The population was randomly divided into two equal-sized groups and the Cox reg ... Full text Link to item Cite

Rethinking sensitivity and specificity.

Journal Article Am J Cardiol · May 1, 1987 Full text Link to item Cite

Localizing coronary artery obstructions with the exercise treadmill test.

Journal Article Ann Intern Med · January 1987 To determine if patterns of ST depression or elevation during exercise testing provide reliable information about the location of an underlying coronary lesion, we studied 452 consecutive patients with one-vessel disease who underwent treadmill testing. Ex ... Full text Link to item Cite

The changing survival benefits of coronary revascularization over time

Journal Article Circulation · January 1, 1987 Previous comparisons of medical and surgical therapy for coronary artery disease were performed in the 1970s and may need to be updated to reflect current treatment efficacy. The purpose of this investigation was to determine the impact on long-term patien ... Cite

Coronary obstructions: Location with exercise electrocardiography

Journal Article Cardiology Board Review · January 1, 1987 Cite

Prognostic implications of angiographically normal and insignificantly narrowed coronary arteries.

Journal Article Am J Cardiol · December 1, 1986 The clinical presentation and prognosis of 1,977 consecutive patients with normal coronary arteries or "insignificant" coronary artery disease (CAD) (no major epicardial artery with 75% or more luminal diameter narrowing) were examined. Compared with patie ... Full text Link to item Cite

Medical, psychological and social correlates of work disability among men with coronary artery disease.

Journal Article Am J Cardiol · November 1, 1986 This study identifies the medical, psychologic and social factors that independently affect employment in patients with coronary artery disease (CAD). At coronary angiography, extensive clinical, psychological and social profiles were collected on 814 men ... Full text Link to item Cite

A simplified method to predict occurrence of complete heart block during acute myocardial infarction.

Journal Article Am J Cardiol · June 1, 1986 Data were analyzed from 698 patients with proved acute myocardial infarction (AMI) to develop a method to predict the occurrence of complete heart block (CHB). The presence of electrocardiographic abnormalities of atrioventricular or intraventricular condu ... Full text Link to item Cite

Randomized trials of coronary artery bypass surgery: impact on clinical practice at Duke University Medical Center.

Journal Article Circulation · December 1985 Trends in practice patterns at Duke University Medical Center were assessed in patient groups comparable to those enrolled in the three major randomized trials of coronary artery bypass grafting (CABG). In addition, changes in practice patterns that appear ... Link to item Cite

Randomized trials of coronary artery bypass surgery: Impact on clinical practice at Duke University Medical Center

Journal Article Circulation · December 1, 1985 Trends in practice patterns at Duke University Medical Center were assessed in patient groups comparable to those enrolled in the three major randomized trials of coronary artery bypass grafting (CABG). In addition, changes in practice patterns that appear ... Cite

Prognostic value of a coronary artery jeopardy score.

Journal Article J Am Coll Cardiol · May 1985 The prognostic value of a coronary artery jeopardy score was evaluated in 462 consecutive nonsurgically treated patients with significant coronary artery disease, but without significant left main coronary stenosis. The jeopardy score is a simple method fo ... Full text Link to item Cite

Factors affecting sensitivity and specificity of exercise electrocardiography. Multivariable analysis.

Journal Article Am J Med · July 1984 Unlike the predictive value of a diagnostic test, which depends on the prevalence of disease in the population tested, its sensitivity and specificity have been assumed to be constants. This assumption was examined in patients who had both exercise electro ... Full text Link to item Cite

Clinical characteristics and long-term survival of patients with variant angina.

Journal Article Circulation · May 1984 We studied 109 consecutive patients with variant angina who underwent cardiac catheterization over an 11 year period. All patients were followed for at least 6 months or until death, and 46 patients (22 treated medically and 24 treated surgically) were fol ... Full text Link to item Cite

Trauma-induced endophthalmitis caused by Acinetobacter anitratus.

Journal Article Br J Ophthalmol · February 1983 A 56-year-old man sustained an intraocular injury by a piece of steel followed by endophthalmitis, which resolved after lensectomy, vitrectomy, and intravitreal injections of gentamicin. Acinetobacter anitratus was the organism responsible for the endophth ... Full text Link to item Cite

Reiter's keratitis.

Journal Article Arch Ophthalmol · May 1982 A distinctive keratitis occurs commonly in Reiter's syndrome. In three patients with Reiter's keratitis, two demonstrated the typical features of prodromal conjunctivitis, subepithelial and anterior stromal infiltrates, ragged epithelial erosions, and spon ... Full text Link to item Cite

Intracorneal lesions produced with focused ultrasound.

Journal Article Curr Eye Res · 1982 Focused ultrasound concentrates a large amount of ultrasonic energy into a small focal zone. We have used new techniques to develop a transducer that creates intracorneal, thermally induced lesions in rabbit eyes in vitro. Histologic study shows that these ... Full text Link to item Cite

Effect of exogenous catecholamines in the amygdala of a 'rage' cat.

Journal Article Appl Neurophysiol · 1975 Minute amounts of epinephrine or norepinephrine alter the behavior of 'rage' cats (prepared by ventromedial hypothalamotomy) when these substances are focally instilled into both amygdalae via chronic brain cannulae capped with a silastic membrane. Hyperac ... Full text Link to item Cite