Scholars@Duke
Michael R Abern

Michael R Abern

Associate Professor of Urology
Urology
michael.abern@duke.edu
200 Trent Drive, DUMC Box 2804, Durham, NC 27710
40 Duke Medicine Circle, DUMC Box 3707, Durham, NC 27710
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Selected Publications

Stockholm3 in a Multiethnic Cohort for Prostate Cancer Detection (SEPTA): A Prospective Multicentered Trial.

Journal Article J Clin Oncol · July 22, 2024 PURPOSE: Asian, Black, and Hispanic men are underrepresented in prostate cancer (PCa) clinical trials. Few novel prostate cancer biomarkers have been validated in diverse cohorts. We aimed to determine if Stockholm3 can improve prostate cancer detection in ... Full text Link to item Cite

Radiation-induced Sarcoma of the Prostate After Treatment for Rhabdomyosarcoma.

Journal Article Urology · July 2024 Rhabdomyosarcoma (RMS) is among the most common pediatric solid malignancies. Fusion-negative, embryonal RMS is the predominant histology among prostate and bladder lesions. Management strategies depend on the clinical stage and risk group. Although the op ... Full text Link to item Cite

NCCN Guidelines® Insights: Bladder Cancer, Version 3.2024.

Journal Article J Natl Compr Canc Netw · May 2024 Bladder cancer, the sixth most common cancer in the United States, is most commonly of the urothelial carcinoma histologic subtype. The clinical spectrum of bladder cancer is divided into 3 categories that differ in prognosis, management, and therapeutic a ... Full text Link to item Cite

Surveillance of non-muscle-invasive bladder cancer with blue-light cystoscopy: a meta-analysis.

Journal Article BJU Int · April 24, 2024 OBJECTIVE: To compare the value of flexible blue-light cystoscopy (BLC) vs flexible white-light cystoscopy (WLC) in the surveillance setting of non-muscle-invasive bladder cancer (NMIBC). METHODS: All major databases were searched for articles published be ... Full text Link to item Cite

Robotic single-port multiquadrant surgery to treat renal tumors and benign abdominal conditions.

Journal Article Minerva Surg · February 2024 BACKGROUND: Multiquadrant procedures are technically more demanding than sequential operations. The new single port (SP) system allows to work in every abdominal quadrant maintaining an adequate triangulation without the need for changes in the port positi ... Full text Link to item Cite

Development and Validation of a Prostate Biopsy Risk Calculator in Black Men.

Journal Article J Urol · February 2024 PURPOSE: We sought to develop and validate a prostate biopsy risk calculator for Black men and compare it with the Prostate Cancer Prevention Trial version 2.0, Prostate Biopsy Collaborative Group, and Kaiser Permanente Prostate Cancer Risk Calculators for ... Full text Link to item Cite

The diagnosis and treatment of castrate-sensitive oligometastatic prostate cancer: A review.

Journal Article Prostate Cancer Prostatic Dis · December 2023 BACKGROUND: Oligometastatic prostate cancer (OMPCa) is emerging as a transitional disease state between localized and polymetastatic disease. This review will assess the current knowledge of castrate-sensitive OMPCa. METHODS: A review of the current litera ... Full text Link to item Cite

Biparametric Quantitative MRI for Prostate Cancer Detection.

Journal Article Top Magn Reson Imaging · December 1, 2023 OBJECTIVES: This study sought to prospectively investigate a novel quantitative biparametric prostate magnetic resonance imaging (MRI) protocol to detect prostate cancer (PCa) in biopsy-naïve men. Secondarily, this study reports the accuracy of fractional ... Full text Link to item Cite

Perioperative outcomes in male patients undergoing cystectomy, radical colorectal procedure or total pelvic exenteration.

Journal Article Transl Androl Urol · November 30, 2023 BACKGROUND: Total pelvic exenteration (TPE) in men is a surgical procedure to treat genitourinary and colorectal malignancies. Despite improvement in multimodal strategies and technology, mortality is still high and literature is limited about perioperativ ... Full text Link to item Cite

Impact of genomic testing on urologists' treatment preference in favorable risk prostate cancer: A randomized trial.

Journal Article Cancer Med · October 2023 INTRODUCTION: The Oncotype Dx Genomic Prostate Score (GPS) is a 17-gene relative expression assay that predicts adverse pathology at prostatectomy. We conducted a novel randomized controlled trial to assess the impact of GPS on urologist's treatment prefer ... Full text Link to item Cite

Prostate-derived circulating microRNAs add prognostic value to prostate cancer risk calculators.

Journal Article bioRxiv · June 6, 2023 Prostate cancer is the second leading cause of malignancy-related deaths among American men. Active surveillance is a safe option for many men with less aggressive disease, yet definitively determining low-risk cancer is challenging with biopsy alone. Here ... Full text Link to item Cite

Advanced chronic kidney disease; A comparison between nephroureterectomy and nephron-sparing surgery for upper tract urothelial carcinoma.

Journal Article Urol Oncol · June 2023 PURPOSE: Renal function outcomes between radical nephroureterectomy (RNU) and nephron-sparing surgery (NSS) for upper tract urothelial carcinoma (UTUC) patients are not well established. We sought to compare the incidence and factors associated with develo ... Full text Link to item Cite

Comparison of Perioperative Outcomes Between Retroperitoneal Single-Port and Multiport Robot-Assisted Partial Nephrectomies.

Journal Article J Endourol · December 2022 Objective: To report early institutional experience with the single-port robotic platform and compare perioperative outcomes between single-port robot-assisted partial nephrectomies (SP-RAPN) and multiport robot-assisted partial nephrectomies (MP-RAPN) whe ... Full text Link to item Cite

Retroperitoneal dermoid cyst presenting with radiculopathy symptoms: a case report.

Journal Article J Surg Case Rep · December 2022 Dermoid cysts rarely present in the retroperitoneal space or during adulthood. In this case report, we describe the clinical presentation, operative and post-operative course of a 31-year old with a retroperitoneal dermoid cyst. The patient presented with ... Full text Open Access Link to item Cite

Reconciling Discordance Between Prostate Biopsy Histology and Magnetic Resonance Imaging Suspicion - Implementation of a Quality Improvement Protocol of Imaging Re-review and Reverse-fusion Target Analysis.

Journal Article Eur Urol Oncol · October 2022 There is uncertainty with how to proceed when targeted prostate biopsy of suspicious multiparametric magnetic resonance imaging (mpMRI) lesions return without clinically significant prostate cancer (csPCa). While possible, there are error sources that coul ... Full text Link to item Cite

NCCN Guidelines® Insights: Bladder Cancer, Version 2.2022.

Journal Article J Natl Compr Canc Netw · August 2022 The NCCN Guidelines for Bladder Cancer provide recommendations for the diagnosis, evaluation, treatment, and follow-up of patients with bladder cancer and other urinary tract cancers (upper tract tumors, urothelial carcinoma of the prostate, primary carcin ... Full text Link to item Cite

Prostate Cancer Disparities in Hispanics Using the National Cancer Database.

Journal Article Urology · July 2022 OBJECTIVES: To evaluate the differences in prostate cancer characteristics and treatment between Hispanic Americans with different countries of origin using the National Cancer Database. METHODS: We performed a retrospective analysis of 54,947 adult Hispan ... Full text Link to item Cite

Genomic Sequencing Should Not be Part of the Standard of Care for Most Urologic Cancers.

Journal Article Eur Urol Focus · May 2022 There are currently few situations in which genomic testing is actionable for genitourinary tumors. Without clear indications or treatment paradigms, genomic sequencing cannot be recommended as a standard of care for genitourinary tumors. ... Full text Link to item Cite

Single-Port robot assisted partial nephrectomy: initial experience and technique with the da Vinci Single-Port platform (IDEAL Phase 1).

Journal Article Minerva Urol Nephrol · April 2022 BACKGROUND: The aim of this paper was to evaluate the safety and feasibility of robotic-assisted laparoscopic partial nephrectomy (RAPN) performed using the da Vinci Single-Port (SP) platform. METHODS: A retrospective review was conducted from December 201 ... Full text Link to item Cite

Stockholm3 in a Multiethnic Cohort for Prostate Cancer Detection (SEPTA): A Prospective Multicentered Trial.

Journal Article J Clin Oncol · July 22, 2024 PURPOSE: Asian, Black, and Hispanic men are underrepresented in prostate cancer (PCa) clinical trials. Few novel prostate cancer biomarkers have been validated in diverse cohorts. We aimed to determine if Stockholm3 can improve prostate cancer detection in ... Full text Link to item Cite

Radiation-induced Sarcoma of the Prostate After Treatment for Rhabdomyosarcoma.

Journal Article Urology · July 2024 Rhabdomyosarcoma (RMS) is among the most common pediatric solid malignancies. Fusion-negative, embryonal RMS is the predominant histology among prostate and bladder lesions. Management strategies depend on the clinical stage and risk group. Although the op ... Full text Link to item Cite

NCCN Guidelines® Insights: Bladder Cancer, Version 3.2024.

Journal Article J Natl Compr Canc Netw · May 2024 Bladder cancer, the sixth most common cancer in the United States, is most commonly of the urothelial carcinoma histologic subtype. The clinical spectrum of bladder cancer is divided into 3 categories that differ in prognosis, management, and therapeutic a ... Full text Link to item Cite

Surveillance of non-muscle-invasive bladder cancer with blue-light cystoscopy: a meta-analysis.

Journal Article BJU Int · April 24, 2024 OBJECTIVE: To compare the value of flexible blue-light cystoscopy (BLC) vs flexible white-light cystoscopy (WLC) in the surveillance setting of non-muscle-invasive bladder cancer (NMIBC). METHODS: All major databases were searched for articles published be ... Full text Link to item Cite

Robotic single-port multiquadrant surgery to treat renal tumors and benign abdominal conditions.

Journal Article Minerva Surg · February 2024 BACKGROUND: Multiquadrant procedures are technically more demanding than sequential operations. The new single port (SP) system allows to work in every abdominal quadrant maintaining an adequate triangulation without the need for changes in the port positi ... Full text Link to item Cite

Development and Validation of a Prostate Biopsy Risk Calculator in Black Men.

Journal Article J Urol · February 2024 PURPOSE: We sought to develop and validate a prostate biopsy risk calculator for Black men and compare it with the Prostate Cancer Prevention Trial version 2.0, Prostate Biopsy Collaborative Group, and Kaiser Permanente Prostate Cancer Risk Calculators for ... Full text Link to item Cite

The diagnosis and treatment of castrate-sensitive oligometastatic prostate cancer: A review.

Journal Article Prostate Cancer Prostatic Dis · December 2023 BACKGROUND: Oligometastatic prostate cancer (OMPCa) is emerging as a transitional disease state between localized and polymetastatic disease. This review will assess the current knowledge of castrate-sensitive OMPCa. METHODS: A review of the current litera ... Full text Link to item Cite

Biparametric Quantitative MRI for Prostate Cancer Detection.

Journal Article Top Magn Reson Imaging · December 1, 2023 OBJECTIVES: This study sought to prospectively investigate a novel quantitative biparametric prostate magnetic resonance imaging (MRI) protocol to detect prostate cancer (PCa) in biopsy-naïve men. Secondarily, this study reports the accuracy of fractional ... Full text Link to item Cite

Perioperative outcomes in male patients undergoing cystectomy, radical colorectal procedure or total pelvic exenteration.

Journal Article Transl Androl Urol · November 30, 2023 BACKGROUND: Total pelvic exenteration (TPE) in men is a surgical procedure to treat genitourinary and colorectal malignancies. Despite improvement in multimodal strategies and technology, mortality is still high and literature is limited about perioperativ ... Full text Link to item Cite

Impact of genomic testing on urologists' treatment preference in favorable risk prostate cancer: A randomized trial.

Journal Article Cancer Med · October 2023 INTRODUCTION: The Oncotype Dx Genomic Prostate Score (GPS) is a 17-gene relative expression assay that predicts adverse pathology at prostatectomy. We conducted a novel randomized controlled trial to assess the impact of GPS on urologist's treatment prefer ... Full text Link to item Cite

Prostate-derived circulating microRNAs add prognostic value to prostate cancer risk calculators.

Journal Article bioRxiv · June 6, 2023 Prostate cancer is the second leading cause of malignancy-related deaths among American men. Active surveillance is a safe option for many men with less aggressive disease, yet definitively determining low-risk cancer is challenging with biopsy alone. Here ... Full text Link to item Cite

Advanced chronic kidney disease; A comparison between nephroureterectomy and nephron-sparing surgery for upper tract urothelial carcinoma.

Journal Article Urol Oncol · June 2023 PURPOSE: Renal function outcomes between radical nephroureterectomy (RNU) and nephron-sparing surgery (NSS) for upper tract urothelial carcinoma (UTUC) patients are not well established. We sought to compare the incidence and factors associated with develo ... Full text Link to item Cite

Comparison of Perioperative Outcomes Between Retroperitoneal Single-Port and Multiport Robot-Assisted Partial Nephrectomies.

Journal Article J Endourol · December 2022 Objective: To report early institutional experience with the single-port robotic platform and compare perioperative outcomes between single-port robot-assisted partial nephrectomies (SP-RAPN) and multiport robot-assisted partial nephrectomies (MP-RAPN) whe ... Full text Link to item Cite

Retroperitoneal dermoid cyst presenting with radiculopathy symptoms: a case report.

Journal Article J Surg Case Rep · December 2022 Dermoid cysts rarely present in the retroperitoneal space or during adulthood. In this case report, we describe the clinical presentation, operative and post-operative course of a 31-year old with a retroperitoneal dermoid cyst. The patient presented with ... Full text Open Access Link to item Cite

Reconciling Discordance Between Prostate Biopsy Histology and Magnetic Resonance Imaging Suspicion - Implementation of a Quality Improvement Protocol of Imaging Re-review and Reverse-fusion Target Analysis.

Journal Article Eur Urol Oncol · October 2022 There is uncertainty with how to proceed when targeted prostate biopsy of suspicious multiparametric magnetic resonance imaging (mpMRI) lesions return without clinically significant prostate cancer (csPCa). While possible, there are error sources that coul ... Full text Link to item Cite

NCCN Guidelines® Insights: Bladder Cancer, Version 2.2022.

Journal Article J Natl Compr Canc Netw · August 2022 The NCCN Guidelines for Bladder Cancer provide recommendations for the diagnosis, evaluation, treatment, and follow-up of patients with bladder cancer and other urinary tract cancers (upper tract tumors, urothelial carcinoma of the prostate, primary carcin ... Full text Link to item Cite

Prostate Cancer Disparities in Hispanics Using the National Cancer Database.

Journal Article Urology · July 2022 OBJECTIVES: To evaluate the differences in prostate cancer characteristics and treatment between Hispanic Americans with different countries of origin using the National Cancer Database. METHODS: We performed a retrospective analysis of 54,947 adult Hispan ... Full text Link to item Cite

Genomic Sequencing Should Not be Part of the Standard of Care for Most Urologic Cancers.

Journal Article Eur Urol Focus · May 2022 There are currently few situations in which genomic testing is actionable for genitourinary tumors. Without clear indications or treatment paradigms, genomic sequencing cannot be recommended as a standard of care for genitourinary tumors. ... Full text Link to item Cite

Single-Port robot assisted partial nephrectomy: initial experience and technique with the da Vinci Single-Port platform (IDEAL Phase 1).

Journal Article Minerva Urol Nephrol · April 2022 BACKGROUND: The aim of this paper was to evaluate the safety and feasibility of robotic-assisted laparoscopic partial nephrectomy (RAPN) performed using the da Vinci Single-Port (SP) platform. METHODS: A retrospective review was conducted from December 201 ... Full text Link to item Cite

Investigating the heterogeneity of viscoelastic properties in prostate cancer using MR elastography at 9.4T in fresh prostatectomy specimens.

Journal Article Magn Reson Imaging · April 2022 PURPOSE: To quantify the heterogeneity of viscoelastic tissue properties in prostatectomy specimens from men with prostate cancer (PC) using MR elastography (MRE) with histopathology as reference. METHODS: Twelve fresh prostatectomy specimens were examined ... Full text Link to item Cite

Progression on active surveillance for prostate cancer in Black men: a systematic review and meta-analysis.

Journal Article Prostate Cancer Prostatic Dis · February 2022 BACKGROUND: Several studies evaluated prostate cancer (PCa) outcomes in Black men on active surveillance (AS); most studies contained few Black men and results were conflicting. We performed a systematic review and meta-analyze of race and outcomes on AS. ... Full text Link to item Cite

Association between environmental quality and prostate cancer stage at diagnosis.

Journal Article Prostate Cancer Prostatic Dis · December 2021 BACKGROUND: Prostate cancer (PC) etiology is up to 57% heritable, with the remainder attributed to environmental exposures. There are limited studies regarding national level environmental exposures and PC aggressiveness, which was the focus of this study ... Full text Link to item Cite

Observational Study of the Association between Air Cadmium Exposure and Prostate Cancer Aggressiveness at Diagnosis among a Nationwide Retrospective Cohort of 230,540 Patients in the United States.

Journal Article Int J Environ Res Public Health · August 6, 2021 Although studies have investigated cadmium and prostate cancer (PC) incidence and mortality, the role of cadmium in PC progression might be more clinically relevant. In this observational study, we assessed the association between air cadmium exposure and ... Full text Link to item Cite

Keratin Profiling by Single-Cell RNA-Sequencing Identifies Human Prostate Stem Cell Lineage Hierarchy and Cancer Stem-Like Cells.

Journal Article Int J Mol Sci · July 28, 2021 Single prostate stem cells can generate stem and progenitor cells to form prostaspheres in 3D culture. Using a prostasphere-based label retention assay, we recently identified keratin 13 (KRT13)-enriched prostate stem cells at single-cell resolution, disti ... Full text Link to item Cite

Erratum: Vitamin D sufficiency enhances differentiation of patient-derived prostate epithelial organoids.

Journal Article iScience · June 25, 2021 [This corrects the article DOI: 10.1016/j.isci.2020.101974.]. ... Full text Link to item Cite

The association of cancer-specific anxiety with disease aggressiveness in men on active surveillance of prostate cancer.

Journal Article Prostate Cancer Prostatic Dis · June 2021 BACKGROUND: Active surveillance (AS) provides appropriate prostate cancer (PCa)-specific survival while minimizing morbidity, but underlying worry of PCa can generate anxiety. The aim of the study is to evaluate anxiety levels in men on AS and how anxiety ... Full text Link to item Cite

Impact of a Genomic Test on Treatment Decision in a Predominantly African American Population With Favorable-Risk Prostate Cancer: A Randomized Trial.

Journal Article J Clin Oncol · May 20, 2021 PURPOSE: The Genomic Prostate Score (GPS), performed on biopsy tissue, predicts adverse outcome in prostate cancer (PCa) and has shown promise for improving patient selection for active surveillance (AS). However, its impact on treatment choice in high-ris ... Full text Link to item Cite

Morbidity and Mortality of Total Pelvic Exenteration for Malignancy in the US.

Journal Article Ann Surg Oncol · May 2021 BACKGROUND: Total pelvic exenterations (TPEs) for malignancies are complex operations often performed by multidisciplinary teams. The differences among primary cancer for TPE and multicentered results are not well described. We aimed to describe TPE outcom ... Full text Link to item Cite

Ethnic variation in prostate cancer detection: a feasibility study for use of the Stockholm3 test in a multiethnic U.S. cohort.

Journal Article Prostate Cancer Prostatic Dis · March 2021 BACKGROUND: The Stockholm3 test improves Gleason Grade Group ≥2 (GG ≥ 2) prostate cancer (PC) detection, however it has not been evaluated in an American cohort where clinical practice patterns and ethnicity differ. We aimed to identify subgroups within a ... Full text Link to item Cite

Phase Ib/II study of durvalumab and guadecitabine in advanced kidney cancer Big Ten Cancer Research Consortium BTCRC GU16-043.

Conference Journal of Clinical Oncology · February 20, 2021 328 Background: Anti-PD1/PDL1 immune checkpoint inhibition (CPI) is active in advanced clear cell RCC, but not all patients benefit. Preclinical studies with the combination of hypomethylating agents and CPI resulted in reversal ... Full text Cite

Vitamin D sufficiency enhances differentiation of patient-derived prostate epithelial organoids.

Journal Article iScience · January 22, 2021 Vitamin D is an essential steroid hormone that regulates systemic calcium homeostasis and cell fate decisions. The prostate gland is hormonally regulated, requiring steroids for proliferation and differentiation of secretory luminal cells. Vitamin D defici ... Full text Link to item Cite

MANAGEMENT OF COLOVESICAL FISTULAS - IS THERE A COMMON PRACTICE?

Conference DISEASES OF THE COLON & RECTUM · 2021 Cite

EDITORIAL COMMENT.

Journal Article Urology · January 2021 Full text Link to item Cite

Prostate cancer assessment using MR elastography of fresh prostatectomy specimens at 9.4 T.

Journal Article Magn Reson Med · July 2020 PURPOSE: Despite its success in the assessment of prostate cancer (PCa), in vivo multiparametric MRI has limitations such as interobserver variability and low specificity. Several MRI methods, among them MR elastography, are currently being discussed as ca ... Full text Link to item Cite

Abstract A066: Performance of the prostate health index (PHI) assay in black men

Conference Cancer Epidemiology, Biomarkers & Prevention · June 1, 2020 AbstractIntroduction: The low specificity of PSA in prostate cancer (PCa) screening has caused excessive biopsies and PCa over-detection. PHI is more specific for clinically significant (cs) PCa (i.e. Gleaso ... Full text Cite

Abstract A082: ENACT: A randomized trial assessing the impact of the Oncotype DX Prostate Cancer Assay on treatment decision in a racially diverse population of men eligible for active surveillance

Conference Cancer Epidemiology, Biomarkers & Prevention · June 1, 2020 AbstractThe Oncotype DX Prostate Cancer Assay® (ODX), a 17-gene expression profile performed on biopsy tissue, has been validated for prediction of adverse pathology at surgery and 10-year risk of metastasis ... Full text Cite

Single port robotic radical prostatectomy with the da Vinci SP platform: a step by step approach.

Journal Article Can J Urol · June 2020 The da Vinci single port (SP) robotic system (Intuitive Surgical, Sunnyvale, CA, USA) is a recently approved robotic platform designed with several modifications to the previously available multi-port robotic systems. This article describes the technique p ... Link to item Cite

A Comparison of Perioperative Outcomes Between Single-port and Multiport Robot-assisted Laparoscopic Prostatectomy.

Journal Article Eur Urol · June 2020 Single-port (SP) robot-assisted laparoscopic prostatectomy (RALP) appears to be a safe and feasible approach for radical prostatectomy, but no prior studies have compared SP-RALP to a multiport (MP) platform. Using retrospective data from a single-center t ... Full text Link to item Cite

Extraperitoneal versus Transperitoneal Single Port Robotic Radical Prostatectomy: A Comparative Analysis of Perioperative Outcomes.

Journal Article J Urol · June 2020 PURPOSE: We compared intraoperative and perioperative outcomes between extraperitoneal and transperitoneal radical prostatectomy performed using a "purpose-designed" single port robotic platform. MATERIALS AND METHODS: A total of 98 patients underwent sing ... Full text Link to item Cite

Helping Men Find Their Way: Improving Prostate Cancer Clinic Attendance via Patient Navigation.

Journal Article J Community Health · June 2020 Navigation programs aim to help patients overcome barriers to cancer diagnosis and treatment. Missed clinic appointments have undesirable effects on the patient, health system, and society, and treatment delays have been shown to result in inferior surgica ... Full text Link to item Cite

Factors Contributing to Healthcare Professional Burnout During the COVID-19 Pandemic: A Rapid Turnaround Global Survey.

Journal Article medRxiv · May 22, 2020 BACKGROUND: Healthcare professionals (HCPs) on the front lines against COVID-19 may face increased workload, and stress. Understanding HCPs risk for burnout is critical to supporting HCPs and maintaining the quality of healthcare during the pandemic. METHO ... Full text Link to item Cite

Society of Behavior Medicine (SBM) Urges Congress to Ensure Affordable Care Act Coverage of Prostate Cancer Screening Support Services for High-Risk Men.

Journal Article Transl Behav Med · May 20, 2020 Prostate cancer (PCa) disproportionately affects African American men. Early detection reduces risk of mortality. The United States Preventive Services Task Force (USPSTF) issued an updated recommendation statement on serum Prostate Specific Antigen (PSA)- ... Full text Link to item Cite

Diagnostic Properties of Total and Free Prostate-Specific Antigen to Predict Overall and Clinically Significant Prostate Cancer Among Men With Low Testosterone and Prior Negative Biopsy.

Journal Article Urology · March 2020 OBJECTIVE: To evaluate whether total serum PSA, free-PSA ratio and PSA density have similar diagnostic properties for detecting prostate cancer (PCa) and clinically-significant (cs) PCa in men with normal testosterone compared to men with low testosterone ... Full text Link to item Cite

Factors contributing to healthcare professional burnout during the COVID-19 pandemic: A rapid turnaround global survey.

Journal Article PLoS One · 2020 BACKGROUND: Healthcare professionals (HCPs) on the front lines against COVID-19 may face increased workload and stress. Understanding HCPs' risk for burnout is critical to supporting HCPs and maintaining the quality of healthcare during the pandemic. METHO ... Full text Link to item Cite

Urology Residents' Experience With Simulation: Initial Evaluation of MRI/US Fusion Biopsy Workshop.

Journal Article Urology · December 2019 OBJECTIVE: To evaluate our initial experience with a multi-institutional workshop model of MRI/US fusion biopsy simulation for resident education. METHODS: Residents from 6 Chicago area urology programs participated in a MRI/US fusion biopsy workshop, whic ... Full text Link to item Cite

The role of WNT10B in normal prostate gland development and prostate cancer.

Journal Article Prostate · October 2019 BACKGROUND: WNT signaling is implicated in embryonic development, and in adult tissue homeostasis, while its deregulation is evident in disease. This study investigates the unique roles of canonical WNT10B in both normal prostate development and prostate c ... Full text Link to item Cite

Point: Should Active Surveillance Be Used for Gleason 3+4 Prostate Cancer?

Journal Article Oncology (Williston Park) · June 19, 2019 Link to item Cite

Predictors of fluoroquinolone-resistant bacteria in the rectal vault of men undergoing prostate biopsy.

Journal Article Prostate Cancer Prostatic Dis · May 2019 IMPORTANCE: Fluoroquinolone (FQ)-resistant rectal vault flora is associated with infectious complications in men undergoing transrectal ultrasound-guided prostate needle biopsy (TRUS-PNB). OBJECTIVE: To determine the patient factors that predict FQ-resista ... Full text Link to item Cite

Correction: Predictors of fluoroquinolone-resistant bacteria in the rectal vault of men undergoing prostate biopsy.

Journal Article Prostate Cancer Prostatic Dis · May 2019 The original version of this article contained an error in the name of author Alfredo Mena Lora. This has now been corrected. ... Full text Link to item Cite

Estrogens and prostate cancer.

Journal Article Prostate Cancer Prostatic Dis · May 2019 BACKGROUND: Hormonal influences such as androgens and estrogens are known contributors in the development and progression of prostate cancer (CaP). While much of the research to the hormonal nature of CaP has focused on androgens, estrogens also have criti ... Full text Link to item Cite

Prostate cancer disparities in Hispanics by country of origin: a nationwide population-based analysis.

Journal Article Prostate Cancer Prostatic Dis · March 2019 BACKGROUND: We sought to evaluate prostate cancer (PCa) characteristics and outcomes of Hispanics living in the United States by country of origin in the Surveillance, Epidemiology and End Results (SEER) program. METHODS: Retrospective analysis of 72,134 a ... Full text Link to item Cite

Constructing and Pilot Testing a Novel Prostate Magnetic Resonance Imaging/Ultrasound Fusion Biopsy Phantom.

Journal Article Urology · February 2019 OBJECTIVE: To describe the design and build of a novel phantom for magnetic resonance imaging (MRI)/ultrasound (US) fusion biopsy and present pilot testing results from a multicenter urology resident training session. METHODS: We cast our phantom from poly ... Full text Link to item Cite

The Association of Previous Prostate Biopsy Related Complications and the Type of Complication with Patient Compliance with Rebiopsy Scheme.

Journal Article J Urol · November 2018 PURPOSE: Prostate biopsy complications have important consequences that may affect patient compliance with rebiopsy schemes. However, to our knowledge this has not been studied in earnest. Thus, we evaluated whether previous prostate biopsy related complic ... Full text Link to item Cite

Effect of blood transfusions on oncological outcomes of surgically treated localized renal cell carcinoma.

Journal Article Urol Oncol · August 2018 OBJECTIVE: To assess the associations between perioperative allogeneic blood transfusions (ABTs) and recurrence, overall and renal cell carcinoma (RCC)-specific survival in patients undergoing surgical treatment for clinically localized disease. MATERIALS ... Full text Link to item Cite

Inflammation on Prostate Needle Biopsy is Associated with Lower Prostate Cancer Risk: A Meta-Analysis.

Journal Article J Urol · May 2018 PURPOSE: We performed a comprehensive literature review and meta-analysis to evaluate the association of inflammation on prostate needle biopsies and prostate cancer risk. MATERIALS AND METHODS: We searched Embase®, PubMed® and Web of Science™ from January ... Full text Link to item Cite

Determinants of Clinic Absenteeism: A Novel Method of Examining Distance from Clinic and Transportation.

Journal Article J Community Health · February 2018 Delayed treatment and non-adherence are associated with inferior prostate cancer (CaP) outcomes. Missed clinic appointments (MA) are one form of non-adherence that may be preventable. We conducted a retrospective cohort study of 1341 scheduled clinic encou ... Full text Link to item Cite

Predictors of Infectious Complications after Targeted Prophylaxis for Prostate Needle Biopsy.

Journal Article J Urol · January 2018 PURPOSE: The incidence of infectious complications after transrectal ultrasound guided prostate needle biopsy is rising. We sought to identify the incidence and predictors of infection in a large cohort of men undergoing biopsy who receive targeted prophyl ... Full text Link to item Cite

Prostate cancer: Overview, detection, treatment

Chapter · January 1, 2018 Prostate cancer is the leading cancer and the third most common cause of cancer-related death in men in the United States. This chapter provides an overview of the epidemiology, risks factors, diagnosis, prognosis, prevention, and treatment of prostate can ... Full text Cite

Testicular cancer

Chapter · January 1, 2018 Testicular cancer is commonly found in young males and if suspected a scrotal ultrasound should be performed. When testicular cancer cannot be ruled out, an orchiectomy is performed. Depending on the histology, treatment post-orchiectomy varies. Treatment ... Full text Cite

Urology Residents' Experience and Attitude Toward Surgical Simulation: Presenting our 4-Year Experience With a Multi-institutional, Multi-modality Simulation Model.

Journal Article Urology · November 2017 OBJECTIVE: To evaluate the Urological resident's attitude and experience with surgical simulation in residency education using a multi-institutional, multi-modality model. MATERIALS AND METHODS: Residents from 6 area urology training programs rotated throu ... Full text Link to item Cite

Descriptive characteristics of prostate cancer in patients with a history of primary male breast cancer - a SEER analysis.

Journal Article BMC Cancer · September 25, 2017 BACKGROUND: Current evidence on risk of prostate cancer following a diagnosis of male breast cancer is limited and guidance for screening in this potentially higher-risk population remainsunclear. Our objective was to quantify prostate cancer risk in men d ... Full text Link to item Cite

Is prostate cancer stage migration continuing for black men in the PSA era?

Journal Article Prostate Cancer Prostatic Dis · June 2017 BACKGROUND: In the United States, disease-specific mortality from prostate cancer (PC) is highest among black men. While the introduction of widespread PSA testing has been associated with a downward stage migration, whether this trend continues in the lat ... Full text Link to item Cite

Biliary Stent Migration: A Rare Cause of a Bladder Stone.

Journal Article Urology · June 2017 Our patient presented with dysuria and pneumaturia without any prior urologic instrumentation. History included choledocolithiasis requiring endoscopic retrograde cholangiopancreatography and biliary stenting. Imaging showed a large bladder stone. The pati ... Full text Link to item Cite

The Development of Prostate Adenocarcinoma in a Transgender Male to Female Patient: Could Estrogen Therapy Have Played a Role?

Journal Article Prostate · June 2017 BACKGROUND: Prostate adenocarcinoma (PCa) is a rare diagnosis in the male to female transgender (MtFT) population with only a few case reports published in the current medical literature. Long standing beliefs of androgen suppression conferring a protectiv ... Full text Link to item Cite

Assessing clinically significant prostate cancer: Diagnostic properties of multiparametric magnetic resonance imaging compared to three-dimensional transperineal template mapping histopathology.

Journal Article Int J Urol · February 2017 OBJECTIVE: To evaluate the diagnostic properties of multiparametric magnetic resonance imaging in the detection, localization and characterization of prostate cancer using three-dimensional transperineal template mapping biopsy histopathology as the compar ... Full text Link to item Cite

Urinary NID2 and TWIST1 methylation to augment conventional urine cytology for the detection of bladder cancer.

Journal Article Cancer Biomark · 2017 BACKGROUND: Abnormal methylation of urinary TWIST1 and NID2 conferred high sensitivity and specificity for the detection of urothelial carcinoma. OBJECTIVE: We examine the performance of the urine-based TWIST1/NID2 methylation assay with the addition of ur ... Full text Link to item Cite

Long-term oncological outcomes of apical positive surgical margins at radical prostatectomy in the Shared Equal Access Regional Cancer Hospital cohort.

Journal Article Prostate Cancer Prostatic Dis · December 2016 BACKGROUND: Approximately 29-38% of all positive surgical margins (PSMs) at radical prostatectomy (RP) involve the apex. The prognostic significance of apical PSM remains unclear. We therefore compared the long-term oncologic outcomes of men with apical PS ... Full text Link to item Cite

Multi-institutional external validation of urinary TWIST1 and NID2 methylation as a diagnostic test for bladder cancer.

Journal Article Urol Oncol · September 2015 OBJECTIVES: We previously reported a clinical trial in which we were unable to replicate the excellent diagnostic metrics produced in the developmental study of the TWIST1 and NID2 gene methylation assay. In this expanded trial with subjects enrolled from ... Full text Link to item Cite

Agent Orange and long-term outcomes after radical prostatectomy.

Conference Urol Oncol · July 2015 PURPOSE: To investigate the association between Agent Orange (AO) exposure and long-term prostate cancer (PC) outcomes. MATERIAL AND METHODS: Data from 1,882 men undergoing radical prostatectomy for PC between 1988 and 2011 at Veterans Affairs Health Care ... Full text Link to item Cite

Cystic nephroma/mixed epithelial stromal tumor: a benign neoplasm with potential for recurrence.

Journal Article Int J Surg Pathol · May 2015 Cystic nephroma (CN) is a rare, benign, renal neoplasm composed of epithelial and stromal elements. Only about 200 cases have been reported since 1892 and recurrence has rarely been observed. We report a 32-year-old Hispanic woman, with a history of a righ ... Full text Link to item Cite

Use of nephron sparing surgery and impact on survival in children with Wilms tumor: a SEER analysis.

Journal Article J Urol · October 2014 PURPOSE: Nephron sparing surgery is the standard of care for many adults with renal tumors and has been described in some children with Wilms tumor. However, beyond case series the data concerning nephron sparing surgery application and outcomes in patient ... Full text Link to item Cite

Clinicopathological characteristics and outcomes of surgically excised renal masses in African Americans.

Journal Article Urol Oncol · July 2014 OBJECTIVES: In the present study, we report on the clinical and pathological characteristics of African American (AA) patients with surgically excised renal masses and assess the associations between race and oncological outcomes. METHODS AND MATERIALS: We ... Full text Link to item Cite

The impact of pathologic staging on the long-term oncologic outcomes of patients with clinically high-risk prostate cancer.

Journal Article Cancer · June 1, 2014 BACKGROUND: In the prostate-specific antigen (PSA) screening era, approximately 15% of US men still present with clinically high-risk prostate cancer (PC). However, high-risk PC may be downgraded/downstaged at radical prostatectomy (RP), making additional ... Full text Link to item Cite

Survival of patients undergoing cytoreductive surgery for metastatic renal cell carcinoma in the targeted-therapy era.

Journal Article Anticancer Res · May 2014 BACKGROUND/AIM: In the cytokine era, cytoreductive nephrectomy (CN) improves survival for patients with metastatic renal cell carcinoma (mRCC). We analyzed the effect of CN on the survival of patients diagnosed with mRCC in the era of tyrosine kinase inhib ... Link to item Cite

Clinical performance and utility of a DNA methylation urine test for bladder cancer.

Journal Article Urol Oncol · January 2014 INTRODUCTION: Abnormal gene methylation has been observed in several cancers. A prior study reported methylation of TWIST1 and NID2 as a quantitative biomarker for urothelial carcinoma, but external validation has yet to be performed. We sought to external ... Full text Link to item Cite

Prostate cancer

Chapter · January 1, 2014 Prostate cancer is the second most common cancer in men worldwide [ 1 ]. In the USA alone, 239,000 men will be diagnosed with prostate cancer in 2013 and 30,000 will die of the disease. Overall, 1 in every 6 men in the USA will be diagnosed with prostate c ... Full text Cite

CYSTIC NEPHROMA: A BENIGN TUMOR OR HAMARTOMATOUS PROLIFERATION?

Conference JOURNAL OF INVESTIGATIVE MEDICINE · 2014 Cite

Metformin does not affect risk of biochemical recurrence following radical prostatectomy: Results from the SEARCH database

Journal Article Prostate Cancer and Prostatic Diseases · December 1, 2013 Background:While epidemiologic studies suggest that metformin use among diabetics may decrease prostate cancer (PC) incidence, the effect of metformin use on PC outcome is unclear. We investigated the association between pre-operative metformin use, dose a ... Full text Cite

Metformin does not affect risk of biochemical recurrence following radical prostatectomy: results from the SEARCH database.

Journal Article Prostate Cancer Prostatic Dis · December 2013 BACKGROUND: While epidemiologic studies suggest that metformin use among diabetics may decrease prostate cancer (PC) incidence, the effect of metformin use on PC outcome is unclear. We investigated the association between pre-operative metformin use, dose ... Full text Link to item Cite

The characteristics of bladder cancer after radiotherapy for prostate cancer.

Journal Article Urol Oncol · November 2013 OBJECTIVES: Prostate radiotherapy (RT) has been associated with an increased risk of bladder cancer (CaB). However it is unknown how prior RT affects the stage, grade, and histology of secondary CaB. While irradiated patients have adverse surgical outcomes ... Full text Link to item Cite

Long-term oncological outcomes of men undergoing radical prostatectomy with preoperative prostate-specific antigen <2.5 ng/ml and 2.5-4 ng/ml.

Journal Article Urol Oncol · November 2013 OBJECTIVES: Prostate-specific antigen (PSA) screening has increased the detection of small, organ-confined tumors, and studies suggest that these patients may have favorable outcomes following radical prostatectomy (RP). To date, there are limited data ava ... Full text Link to item Cite

Characteristics of patients diagnosed with both melanoma and renal cell cancer.

Journal Article Cancer Causes Control · November 2013 BACKGROUND: Patients with renal cell carcinoma (RCC) and malignant melanoma (MM) have an increased risk of additional malignancies. We identified characteristics of MM and RCC associated with a patient developing both cancers. METHODS: A total of 147,656 c ... Full text Link to item Cite

The effect of dietary sodium and fructose intake on urine and serum parameters of stone formation in a pediatric mouse model: a pilot study.

Journal Article J Urol · October 2013 PURPOSE: Dietary factors have a role in stone disease in adults but little is known about the relationship in children. We tested whether diet could alter urine and serum parameters in a pediatric mouse model. MATERIALS AND METHODS: We randomized 30 female ... Full text Link to item Cite

Radiation exposure associated with dedicated renal mass computed tomography protocol: impact of patient characteristics.

Journal Article J Endourol · September 2013 BACKGROUND AND PURPOSE: Renal mass protocol CT (RMP-CT) using multiphase abdomen and pelvis CT imaging is the mainstay for diagnosis, characterization, and follow-up for renal masses; however, it is associated with ionizing radiation to the patient. We sou ... Full text Link to item Cite

Short-term functional outcomes and complications associated with transperineal template prostate mapping biopsy.

Journal Article Urology · July 2013 OBJECTIVE: To assess the complications and erectile and urinary functional outcomes of transperineal template mapping biopsy (TTMB) of the prostate. METHODS: We retrospectively reviewed the records of 84 patients undergoing TTMB at our institution and reco ... Full text Link to item Cite

Perioperative intravesical chemotherapy in non-muscle-invasive bladder cancer: a systematic review and meta-analysis.

Journal Article J Natl Compr Canc Netw · April 1, 2013 The role for a single dose of intravesical chemotherapy (IVC) after transurethral resection (TUR) remains unclear in patients with non-muscle-invasive bladder cancer (NMIBC). Several recent randomized clinical trials (RCTs) have evaluated its effect on rec ... Full text Link to item Cite

Does a positive response to spermatic cord block predict response to microdenervation of the spermatic cord for chronic scrotal content pain?

Journal Article J Sex Med · March 2013 INTRODUCTION: Microdenervation of the spermatic cord (MDSC) has been demonstrated to be an effective treatment for men with intractable scrotal content pain. AIM: This study evaluates the correlation between a positive response to a spermatic cord block wi ... Full text Link to item Cite

Race is associated with discontinuation of active surveillance of low-risk prostate cancer: results from the Duke Prostate Center.

Journal Article Prostate Cancer Prostatic Dis · March 2013 BACKGROUND: Active surveillance (AS) is increasingly utilized in low-risk prostate cancer (PC) patients. Although black race has traditionally been associated with adverse PC characteristics, its prognostic value for patients managed with AS is unclear. ME ... Full text Link to item Cite

African-American men with low-grade prostate cancer have higher tumor burdens: results from the Duke Prostate Center.

Journal Article Prostate Cancer Prostatic Dis · March 2013 BACKGROUND: To investigate racial differences in tumor burden (cancer volume, cancer percentage and cancer to PSA ratios) in a large cohort of men undergoing radical prostatectomy (RP). METHODS: Demographic, clinical and pathological data of patients under ... Full text Link to item Cite

Delayed radical prostatectomy for intermediate-risk prostate cancer is associated with biochemical recurrence: possible implications for active surveillance from the SEARCH database.

Journal Article Prostate · March 2013 INTRODUCTION: Active surveillance (AS) is increasingly accepted as appropriate management for low-risk prostate cancer (PC) patients. It is unknown whether delaying radical prostatectomy (RP) is associated with increased risk of biochemical recurrence (BCR ... Full text Link to item Cite

Race is associated with discontinuation of active surveillance of low-risk prostate cancer: results from the Duke Prostate Center.

Journal Article Prostate cancer and prostatic diseases · March 1, 2013 Active surveillance (AS) is increasingly utilized in low-risk prostate cancer (PC) patients. Although black race has traditionally been associated with adverse PC characteristics, its prognostic value for patients managed with AS is unclear. A retrospectiv ... Cite

African-American men with low-grade prostate cancer have higher tumor burdens: results from the Duke Prostate Center.

Journal Article Prostate cancer and prostatic diseases · March 1, 2013 To investigate racial differences in tumor burden (cancer volume, cancer percentage and cancer to PSA ratios) in a large cohort of men undergoing radical prostatectomy (RP). Demographic, clinical and pathological data of patients undergoing RP between 1993 ... Cite

Evolution of the concept of focal therapy for prostate cancer.

Journal Article Oncology (Williston Park) · January 2013 The landscape of prostate cancer has been rapidly evolving, and technological advances in imaging and biopsy tools offer novel approaches to focal therapy. In this dynamic environment, the role of focal therapy for prostate cancer is being shaped both by a ... Link to item Cite

Evolution of the concept of focal therapy for prostate cancer.

Journal Article Oncology (Williston Park, N.Y.) · January 1, 2013 The landscape of prostate cancer has been rapidly evolving, and technological advances in imaging and biopsy tools offer novel approaches to focal therapy. In this dynamic environment, the role of focal therapy for prostate cancer is being shaped both by a ... Cite

Hyperthermia as adjunct to intravesical chemotherapy for bladder cancer.

Journal Article Biomed Res Int · 2013 Nonmuscle invasive bladder cancer remains a very costly cancer to manage because of high recurrence rates requiring long-term surveillance and treatment. Emerging evidence suggests that adjunct and concurrent use of hyperthermia with intravesical chemother ... Full text Link to item Cite

Renal mass anatomic characteristics and perioperative outcomes of laparoscopic partial nephrectomy: a critical analysis.

Journal Article J Endourol · October 2012 BACKGROUND AND PURPOSE: Anatomic parameters determining renal mass complexity have been used in a number of proposed scoring systems despite lack of a critical analysis of their independent contributions. We sought to assess the independent contribution of ... Full text Link to item Cite

EFFECTS OF SODIUM AND FRUCTOSE INTAKE ON PEDIATRIC STONE FORMATION

Conference JOURNAL OF ENDOUROLOGY · September 1, 2012 Link to item Cite

Characteristics and outcomes of tumors arising from the distal nephron.

Journal Article Urology · July 2012 OBJECTIVE: To compare the characteristics and predictors of cancer-specific survival (CSS) of 2 rare distal nephron tumors--medullary renal cell carcinoma (MRCC) and collecting duct carcinoma (CDC). METHODS: All cases of histologically verified MRCC and CD ... Full text Link to item Cite

Abstract 5631: The effect of pomegranate extract dose on prostate cancer growth in a carbohydrate restricted mouse xenograft model

Conference Cancer Research · April 15, 2012 AbstractIntroduction: Preclinical studies have shown that dietary carbohydrate restriction slows prostate tumor growth in multiple xenograft models in part due to a reduction insulin-like growth factor (IGF) ... Full text Cite

Abstract 5255: Methionine restriction limits prostate tumor cell proliferation

Conference Cancer Research · April 15, 2012 AbstractIntroduction: Methionine restriction has been shown to have growth inhibitory effects in a number of tumor cell lines in vitro. Methionine restriction has previously been demonstrated to slow PC-3 pr ... Full text Cite

Focal therapy of prostate cancer: evidence-based analysis for modern selection criteria.

Journal Article Curr Urol Rep · April 2012 Focal therapy for prostate cancer has been increasingly utilized with the goal of effective disease control while maximizing patient functional outcomes. The optimal patient selection criteria are not known and therefore are not standardized. This review c ... Full text Link to item Cite

Predicting erectile dysfunction following surgical correction of Peyronie's disease without inflatable penile prosthesis placement: vascular assessment and preoperative risk factors.

Journal Article J Sex Med · January 2012 INTRODUCTION: Surgical therapy remains the gold standard treatment for Peyronie's Disease (PD). Surgical options include plication, grafting, and placement of inflatable penile prosthesis (IPP). Postoperative erectile dysfunction (ED) is a potential compli ... Full text Link to item Cite

Combination of penile traction, intralesional verapamil, and oral therapies for Peyronie's disease.

Journal Article J Sex Med · January 2012 Introduction. There is no current consensus as to the most effective non-surgical therapy for Peyronie's disease (PD).Aim. To assess the benefit of penile traction therapy (PTT) when added to intralesional verapamil injections (IVI) combined with oral L-ar ... Full text Link to item Cite

Marital status independently predicts testis cancer survival--an analysis of the SEER database.

Journal Article Urol Oncol · 2012 OBJECTIVES: Previous reports have shown that married men with malignancies have improved 10-year survival over unmarried men. We sought to investigate the effect of marital status on 10-year survival in a U.S. population-based cohort of men with testis can ... Full text Link to item Cite

An update on TroVax for the treatment of progressive castration-resistant prostate cancer.

Journal Article Onco Targets Ther · 2011 Prostate cancer is a common human malignancy with few effective therapeutic options for treating advanced castration-resistant disease. The potential therapeutic effectiveness of immunotherapy and vaccines, in particular, has gained popularity based on the ... Full text Link to item Cite

Ureteral mullerianosis.

Journal Article J Endourol · December 2009 Full text Link to item Cite

Penile shortening after radical prostatectomy and Peyronie's surgery.

Journal Article Curr Urol Rep · November 2009 Penile shortening following radical prostatectomy and straightening procedures for Peyronie's disease can be a devastating and unwelcome side effect of these operations. The majority of men undergoing radical prostatectomy for prostate cancer have a measur ... Full text Link to item Cite

Ketoconazole and prednisone to prevent recurrent ischemic priapism.

Journal Article J Urol · October 2009 PURPOSE: To our knowledge no standard therapy exists for the prevention of recurrent ischemic priapism. We used ketoconazole and prednisone with dosing titrated according to serum testosterone levels to suppress sleep related erections in an attempt to pre ... Full text Link to item Cite

Peyronie's disease: evaluation and review of nonsurgical therapy.

Journal Article ScientificWorldJournal · July 27, 2009 The purpose of our study was to outline the evaluation of the Peyronie's disease (PD) patient and review the available nonsurgical treatments. A review of the literature on oral, intralesional, external energy, iontophoresis, and mechanical therapies for P ... Full text Link to item Cite

Persistent motile sperm after ligation band vasectomy.

Journal Article J Urol · November 2006 PURPOSE: We evaluated the efficacy and mechanism of failure in a small case series of VasClip vasectomies. MATERIALS AND METHODS: Between September 2003 and March 2004, 8 patients underwent elective vasectomy using the VasClip ligation band. Microscopic se ... Full text Link to item Cite