Scholars@Duke
Miguel Angelo L. Nicolelis

Miguel Angelo L. Nicolelis

Professor Emeritus of Neurobiology
Neurobiology
nicoleli@neuro.duke.edu
Gsrbii 210 Research Drive, Box 103905 Room 4028, Durham, NC 27710
Gsrbii 210 Research Drive, Box 103905 Room 4028, Durham, NC 27710

Selected Publications

Training with noninvasive brain-machine interface, tactile feedback, and locomotion to enhance neurological recovery in individuals with complete paraplegia: a randomized pilot study.

Journal Article Sci Rep · November 29, 2022 In recent years, our group and others have reported multiple cases of consistent neurological recovery in people with spinal cord injury (SCI) following a protocol that integrates locomotion training with brain machine interfaces (BMI). The primary objecti ... Full text Link to item Cite

Capturing spike train temporal pattern with wavelet average coefficient for brain machine interface.

Journal Article Sci Rep · September 24, 2021 Motor brain machine interfaces (BMIs) directly link the brain to artificial actuators and have the potential to mitigate severe body paralysis caused by neurological injury or disease. Most BMI systems involve a decoder that analyzes neural spike counts to ... Full text Link to item Cite

The impact of super-spreader cities, highways, and intensive care availability in the early stages of the COVID-19 epidemic in Brazil.

Journal Article Sci Rep · June 21, 2021 Although international airports served as main entry points for SARS-CoV-2, the factors driving the uneven geographic spread of COVID-19 cases and deaths in Brazil remain mostly unknown. Here we show that three major factors influenced the early macro-geog ... Full text Link to item Cite

Generating artificial sensations with spinal cord stimulation in primates and rodents.

Journal Article Brain Stimul · 2021 For patients who have lost sensory function due to a neurological injury such as spinal cord injury (SCI), stroke, or amputation, spinal cord stimulation (SCS) may provide a mechanism for restoring somatic sensations via an intuitive, non-visual pathway. I ... Full text Link to item Cite

Neuroengineering challenges of fusing robotics and neuroscience.

Journal Article Sci Robot · December 9, 2020 Advances in neuroscience are inspiring developments in robotics and vice versa. ... Full text Link to item Cite

A Brain to Spine Interface for Transferring Artificial Sensory Information.

Journal Article Sci Rep · January 21, 2020 Lack of sensory feedback is a major obstacle in the rapid absorption of prosthetic devices by the brain. While electrical stimulation of cortical and subcortical structures provides unique means to deliver sensory information to higher brain structures, th ... Full text Open Access Link to item Cite

The true creator of everything: How the human brain shaped the universe as we know it

Book · January 7, 2020 A radically new cosmological view from a groundbreaking neuroscientist who places the human brain at the center of humanity’s universe Renowned neuroscientist Miguel Nicolelis introduces a revolutionary new theory of how the human brain evolved to become a ... Cite

Analysis of neuronal ensemble activity reveals the pitfalls and shortcomings of rotation dynamics.

Journal Article Sci Rep · December 12, 2019 Back in 2012, Churchland and his colleagues proposed that "rotational dynamics", uncovered through linear transformations of multidimensional neuronal data, represent a fundamental type of neuronal population processing in a variety of organisms, from the ... Full text Link to item Cite

Author Correction: Non-invasive, Brain-controlled Functional Electrical Stimulation for Locomotion Rehabilitation in Individuals with Paraplegia.

Journal Article Sci Rep · December 4, 2019 An amendment to this paper has been published and can be accessed via a link at the top of the paper. ... Full text Link to item Cite

Creating a neuroprosthesis for active tactile exploration of textures.

Journal Article Proc Natl Acad Sci U S A · October 22, 2019 Intracortical microstimulation (ICMS) of the primary somatosensory cortex (S1) can produce percepts that mimic somatic sensation and, thus, has potential as an approach to sensorize prosthetic limbs. However, it is not known whether ICMS could recreate act ... Full text Link to item Cite

A Brain to Spine Interface for Transferring Artificial Sensory Information

Journal Article · October 17, 2019 Abstract Lack of sensory feedback is a major obstacle in the rapid absorption of prosthetic devices by the brain. While electrical stimulation of cortical and subcortical structures provides unique means to deliver sensory information to higher brain struc ... Full text Cite

Decoding Movements from Cortical Ensemble Activity Using a Long Short-Term Memory Recurrent Network.

Journal Article Neural Comput · June 2019 Although many real-time neural decoding algorithms have been proposed for brain-machine interface (BMI) applications over the years, an optimal, consensual approach remains elusive. Recent advances in deep learning algorithms provide new opportunities for ... Full text Link to item Cite

Non-invasive, Brain-controlled Functional Electrical Stimulation for Locomotion Rehabilitation in Individuals with Paraplegia.

Journal Article Sci Rep · May 1, 2019 Spinal cord injury (SCI) impairs the flow of sensory and motor signals between the brain and the areas of the body located below the lesion level. Here, we describe a neurorehabilitation setup combining several approaches that were shown to have a positive ... Full text Link to item Cite

Frequency-specific coupling in fronto-parieto-occipital cortical circuits underlie active tactile discrimination.

Journal Article Sci Rep · March 25, 2019 Processing of tactile sensory information in rodents is critically dependent on the communication between the primary somatosensory cortex (S1) and higher-order integrative cortical areas. Here, we have simultaneously characterized single-unit activity and ... Full text Link to item Cite

Place Cell-Like Activity in the Primary Sensorimotor and Premotor Cortex During Monkey Whole-Body Navigation.

Journal Article Sci Rep · June 15, 2018 Primary motor (M1), primary somatosensory (S1) and dorsal premotor (PMd) cortical areas of rhesus monkeys previously have been associated only with sensorimotor control of limb movements. Here we show that a significant number of neurons in these areas als ... Full text Link to item Cite

Interbrain cortical synchronization encodes multiple aspects of social interactions in monkey pairs.

Journal Article Sci Rep · March 29, 2018 While it is well known that the primate brain evolved to cope with complex social contingencies, the neurophysiological manifestation of social interactions in primates is not well understood. Here, concurrent wireless neuronal ensemble recordings from pai ... Full text Link to item Cite

Training with brain-machine interfaces, visuo-tactile feedback and assisted locomotion improves sensorimotor, visceral, and psychological signs in chronic paraplegic patients.

Journal Article PLoS One · 2018 Spinal cord injury (SCI) induces severe deficiencies in sensory-motor and autonomic functions and has a significant negative impact on patients' quality of life. There is currently no systematic rehabilitation technique assuring recovery of the neurologica ... Full text Link to item Cite

Cortical neurons multiplex reward-related signals along with sensory and motor information.

Journal Article Proc Natl Acad Sci U S A · June 13, 2017 Rewards are known to influence neural activity associated with both motor preparation and execution. This influence can be exerted directly upon the primary motor (M1) and somatosensory (S1) cortical areas via the projections from reward-sensitive dopamine ... Full text Open Access Link to item Cite

Electrical stimulation of the dorsal columns of the spinal cord for Parkinson's disease.

Journal Article Mov Disord · June 2017 Spinal cord stimulation has been used for the treatment of chronic pain for decades. In 2009, our laboratory proposed, based on studies in rodents, that electrical stimulation of the dorsal columns of the spinal cord could become an effective treatment for ... Full text Open Access Link to item Cite

Brain-Machine Interfaces: From Basic Science to Neuroprostheses and Neurorehabilitation.

Journal Article Physiol Rev · April 2017 Brain-machine interfaces (BMIs) combine methods, approaches, and concepts derived from neurophysiology, computer science, and engineering in an effort to establish real-time bidirectional links between living brains and artificial actuators. Although theor ... Full text Link to item Cite

EXiO-A Brain-Controlled Lower Limb Exoskeleton for Rhesus Macaques.

Journal Article IEEE Trans Neural Syst Rehabil Eng · February 2017 Recent advances in the field of brain-machine interfaces (BMIs) have demonstrated enormous potential to shape the future of rehabilitation and prosthetic devices. Here, a lower-limb exoskeleton controlled by the intracortical activity of an awake behaving ... Full text Link to item Cite

Are we at risk of becoming biological digital machines?

Journal Article Nature Human Behaviour · January 10, 2017 Full text Cite

Cortical Neuroprosthesis Merges Visible and Invisible Light Without Impairing Native Sensory Function.

Journal Article eNeuro · 2017 Adult rats equipped with a sensory prosthesis, which transduced infrared (IR) signals into electrical signals delivered to somatosensory cortex (S1), took approximately 4 d to learn a four-choice IR discrimination task. Here, we show that when such IR sign ... Full text Link to item Cite

Assimilation of virtual legs and perception of floor texture by complete paraplegic patients receiving artificial tactile feedback.

Journal Article Sci Rep · September 19, 2016 Spinal cord injuries disrupt bidirectional communication between the patient's brain and body. Here, we demonstrate a new approach for reproducing lower limb somatosensory feedback in paraplegics by remapping missing leg/foot tactile sensations onto the sk ... Full text Link to item Cite

A Closed Loop Brain-machine Interface for Epilepsy Control Using Dorsal Column Electrical Stimulation.

Journal Article Sci Rep · September 8, 2016 Although electrical neurostimulation has been proposed as an alternative treatment for drug-resistant cases of epilepsy, current procedures such as deep brain stimulation, vagus, and trigeminal nerve stimulation are effective only in a fraction of the pati ... Full text Open Access Link to item Cite

Long-Term Training with a Brain-Machine Interface-Based Gait Protocol Induces Partial Neurological Recovery in Paraplegic Patients.

Journal Article Sci Rep · August 11, 2016 Brain-machine interfaces (BMIs) provide a new assistive strategy aimed at restoring mobility in severely paralyzed patients. Yet, no study in animals or in human subjects has indicated that long-term BMI training could induce any type of clinical recovery. ... Full text Link to item Cite

An automatic experimental apparatus to study arm reaching in New World monkeys.

Journal Article J Neurosci Methods · May 1, 2016 BACKGROUND: Several species of the New World monkeys have been used as experimental models in biomedical and neurophysiological research. However, a method for controlled arm reaching tasks has not been developed for these species. NEW METHOD: We have deve ... Full text Link to item Cite

Wireless Cortical Brain-Machine Interface for Whole-Body Navigation in Primates.

Journal Article Sci Rep · March 3, 2016 Several groups have developed brain-machine-interfaces (BMIs) that allow primates to use cortical activity to control artificial limbs. Yet, it remains unknown whether cortical ensembles could represent the kinematics of whole-body navigation and be used t ... Full text Link to item Cite

Embedding a Panoramic Representation of Infrared Light in the Adult Rat Somatosensory Cortex through a Sensory Neuroprosthesis.

Journal Article J Neurosci · February 24, 2016 Can the adult brain assimilate a novel, topographically organized, sensory modality into its perceptual repertoire? To test this, we implemented a microstimulation-based neuroprosthesis that rats used to discriminate among infrared (IR) light sources. This ... Full text Link to item Cite

Cortical and thalamic contributions to response dynamics across layers of the primary somatosensory cortex during tactile discrimination.

Journal Article J Neurophysiol · September 2015 Tactile information processing in the rodent primary somatosensory cortex (S1) is layer specific and involves modulations from both thalamocortical and cortico-cortical loops. However, the extent to which these loops influence the dynamics of the primary s ... Full text Link to item Cite

Computing Arm Movements with a Monkey Brainet.

Journal Article Sci Rep · July 9, 2015 Traditionally, brain-machine interfaces (BMIs) extract motor commands from a single brain to control the movements of artificial devices. Here, we introduce a Brainet that utilizes very-large-scale brain activity (VLSBA) from two (B2) or three (B3) nonhuma ... Full text Link to item Cite

Building an organic computing device with multiple interconnected brains.

Journal Article Sci Rep · July 9, 2015 Recently, we proposed that Brainets, i.e. networks formed by multiple animal brains, cooperating and exchanging information in real time through direct brain-to-brain interfaces, could provide the core of a new type of computing device: an organic computer ... Full text Open Access Link to item Cite

Direct Cortical Control of Primate Whole-Body Navigation in a Mobile Robotic Wheelchair

Journal Article · April 9, 2015 We and others have previously developed brain-machine-interfaces (BMIs), which allowed ensembles of cortical neurons to control artificial limbs (1-4). However, it is unclear whether cortical ensembles could operate a BMI for whole-body navigation. Here we ... Link to item Cite

Joint cross-correlation analysis reveals complex, time-dependent functional relationship between cortical neurons and arm electromyograms.

Journal Article J Neurophysiol · December 1, 2014 Correlation between cortical activity and electromyographic (EMG) activity of limb muscles has long been a subject of neurophysiological studies, especially in terms of corticospinal connectivity. Interest in this issue has recently increased due to the de ... Full text Link to item Cite

Spinal cord stimulation alleviates motor deficits in a primate model of Parkinson disease.

Journal Article Neuron · November 19, 2014 Although deep brain electrical stimulation can alleviate the motor symptoms of Parkinson disease (PD), just a small fraction of patients with PD can take advantage of this procedure due to its invasive nature. A significantly less invasive method--epidural ... Full text Link to item Cite

Basal forebrain dynamics during a tactile discrimination task.

Journal Article J Neurophysiol · September 1, 2014 The nucleus basalis (NB) is a cholinergic neuromodulatory structure that projects liberally to the entire cortical mantle and regulates information processing in all cortical layers. Here, we recorded activity from populations of single units in the NB as ... Full text Link to item Cite

Chronic, wireless recordings of large-scale brain activity in freely moving rhesus monkeys.

Journal Article Nat Methods · June 2014 Advances in techniques for recording large-scale brain activity contribute to both the elucidation of neurophysiological principles and the development of brain-machine interfaces (BMIs). Here we describe a neurophysiological paradigm for performing tether ... Full text Link to item Cite

Chronic spinal cord electrical stimulation protects against 6-hydroxydopamine lesions.

Journal Article Sci Rep · January 23, 2014 Although L-dopa continues to be the gold standard for treating motor symptoms of Parkinson's disease (PD), it presents long-term complications. Deep brain stimulation is effective, but only a small percentage of idiopathic PD patients are eligible. Based o ... Full text Open Access Link to item Cite

Chronic, wireless recordings of large-scale brain activity in freely moving rhesus monkeys

Journal Article Nature Methods · January 1, 2014 Advances in techniques for recording large-scale brain activity contribute to both the elucidation of neurophysiological principles and the development of brain-machine interfaces (BMIs). Here we describe a neurophysiological paradigm for performing tether ... Full text Cite

Signal-independent timescale analysis (SITA) and its application for neural coding during reaching and walking.

Journal Article Front Comput Neurosci · 2014 What are the relevant timescales of neural encoding in the brain? This question is commonly investigated with respect to well-defined stimuli or actions. However, neurons often encode multiple signals, including hidden or internal, which are not experiment ... Full text Link to item Cite

Brain-to-Brain Interfaces: When Reality Meets Science Fiction.

Journal Article Cerebrum · 2014 Every memory that we have, act that we perform, and feeling that we experience creates brainstorms—interactions of millions of cells that produce electrical signals. Neuroscientists are now able to record those signals, extract the kind of motor commands t ... Link to item Cite

A brain-machine interface enables bimanual arm movements in monkeys.

Journal Article Sci Transl Med · November 6, 2013 Brain-machine interfaces (BMIs) are artificial systems that aim to restore sensation and movement to paralyzed patients. So far, BMIs have enabled only one arm to be moved at a time. Control of bimanual arm movements remains a major challenge. We have deve ... Full text Link to item Cite

Expanding the primate body schema in sensorimotor cortex by virtual touches of an avatar.

Journal Article Proc Natl Acad Sci U S A · September 10, 2013 The brain representation of the body, called the body schema, is susceptible to plasticity. For instance, subjects experiencing a rubber hand illusion develop a sense of ownership of a mannequin hand when they view it being touched while tactile stimuli ar ... Full text Link to item Cite

Cortical-amygdalar circuit dysfunction in a genetic mouse model of serotonin deficiency.

Journal Article J Neurosci · March 6, 2013 Although the majority of first-line antidepressants increase brain serotonin and rare polymorphisms in tryptophan hydroxlase-2 (Tph2), the rate-limiting enzyme in the brain serotonin synthesis pathway, have been identified in cohorts of subjects with major ... Full text Link to item Cite

Simultaneous top-down modulation of the primary somatosensory cortex and thalamic nuclei during active tactile discrimination.

Journal Article J Neurosci · February 27, 2013 The rat somatosensory system contains multiple thalamocortical loops (TCLs) that altogether process, in fundamentally different ways, tactile stimuli delivered passively or actively sampled. To elucidate potential top-down mechanisms that govern TCL proces ... Full text Link to item Cite

A brain-to-brain interface for real-time sharing of sensorimotor information.

Journal Article Sci Rep · 2013 A brain-to-brain interface (BTBI) enabled a real-time transfer of behaviorally meaningful sensorimotor information between the brains of two rats. In this BTBI, an "encoder" rat performed sensorimotor tasks that required it to select from two choices of ta ... Full text Link to item Cite

Perceiving invisible light through a somatosensory cortical prosthesis.

Journal Article Nat Commun · 2013 Sensory neuroprostheses show great potential for alleviating major sensory deficits. It is not known, however, whether such devices can augment the subject's normal perceptual range. Here we show that adult rats can learn to perceive otherwise invisible in ... Full text Link to item Cite

Stochastic facilitation of artificial tactile sensation in primates.

Journal Article J Neurosci · October 10, 2012 Artificial sensation via electrical or optical stimulation of brain sensory areas offers a promising treatment for sensory deficits. For a brain-machine-brain interface, such artificial sensation conveys feedback signals from a sensorized prosthetic limb. ... Full text Link to item Cite

Mind in motion.

Journal Article Sci Am · September 2012 Full text Link to item Cite

Mind in motion

Journal Article Scientific American · September 1, 2012 Full text Cite

Appetitive changes during salt deprivation are paralleled by widespread neuronal adaptations in nucleus accumbens, lateral hypothalamus, and central amygdala.

Journal Article J Neurophysiol · August 2012 Salt appetite is a goal-directed behavior in which salt-deprived animals ingest high salt concentrations that they otherwise find aversive. Because forebrain areas such as the lateral hypothalamus (LH), central amygdala (CeA), and nucleus accumbens (NAc) a ... Full text Link to item Cite

Subcortical neuronal ensembles: an analysis of motor task association, tremor, oscillations, and synchrony in human patients.

Journal Article J Neurosci · June 20, 2012 Deep brain stimulation (DBS) has expanded as an effective treatment for motor disorders, providing a valuable opportunity for intraoperative recording of the spiking activity of subcortical neurons. The properties of these neurons and their potential utili ... Full text Link to item Cite

High-side digitally current controlled biphasic bipolar microstimulator.

Journal Article IEEE Trans Neural Syst Rehabil Eng · May 2012 Electrical stimulation of nervous tissue has been extensively used as both a tool in experimental neuroscience research and as a method for restoring of neural functions in patients suffering from sensory and motor disabilities. In the central nervous syst ... Full text Link to item Cite

Frontiers in neuroscience

Chapter · April 26, 2012 Cite

Reprogramming movements: extraction of motor intentions from cortical ensemble activity when movement goals change.

Journal Article Front Neuroeng · 2012 The ability to inhibit unwanted movements and change motor plans is essential for behaviors of advanced organisms. The neural mechanisms by which the primate motor system rejects undesired actions have received much attention during the last decade, but it ... Full text Link to item Cite

The insular cortex controls food preferences independently of taste receptor signaling.

Journal Article Front Syst Neurosci · 2012 The insular cortex (IC) contains the primary sensory cortex for oral chemosensation including gustation, and its integrity is required for appropriate control of feeding behavior. However, it remains unknown whether the role of this brain area in food sele ... Full text Link to item Cite

Virtual active touch using randomly patterned intracortical microstimulation.

Journal Article IEEE Trans Neural Syst Rehabil Eng · January 2012 Intracortical microstimulation (ICMS) has promise as a means for delivering somatosensory feedback in neuroprosthetic systems. Various tactile sensations could be encoded by temporal, spatial, or spatiotemporal patterns of ICMS. However, the applicability ... Full text Link to item Cite

INTRAVASCULAR FOOD REWARD

Conference EUROPEAN PSYCHIATRY · January 1, 2012 Link to item Cite

Reprogramming movements: Extraction of motor intentions from cortical ensemble activity when movement goals change

Journal Article Frontiers in Neuroengineering · 2012 The ability to inhibit unwanted movements and change motor plans is essential for behaviors of advanced organisms. The neural mechanisms by which the primate motor system rejects undesired actions have received much attention during the last decade, but it ... Full text Cite

Adaptive decoding for brain-machine interfaces through Bayesian parameter updates.

Journal Article Neural Comput · December 2011 Brain-machine interfaces (BMIs) transform the activity of neurons recorded in motor areas of the brain into movements of external actuators. Representation of movements by neuronal populations varies over time, during both voluntary limb movements and move ... Full text Link to item Cite

A distinctive subpopulation of medial septal slow-firing neurons promote hippocampal activation and theta oscillations.

Journal Article J Neurophysiol · November 2011 The medial septum-vertical limb of the diagonal band of Broca (MSvDB) is important for normal hippocampal functions and theta oscillations. Although many previous studies have focused on understanding how MSVDB neurons fire rhythmic bursts to pace hippocam ... Full text Link to item Cite

Active tactile exploration using a brain-machine-brain interface.

Journal Article Nature · October 5, 2011 Brain-machine interfaces use neuronal activity recorded from the brain to establish direct communication with external actuators, such as prosthetic arms. It is hoped that brain-machine interfaces can be used to restore the normal sensorimotor functions of ... Full text Link to item Cite

Series Preface

Book · September 9, 2011 Cite

Neurobiology of Depression

Book · September 9, 2011 Major depressive disorders have recently been associated with impairments in signaling pathways that regulate neuroplasticity and cell survival. Agents designed to directly target molecules in these pathways hold promise as new therapeutics for depression. ... Cite

Series preface

Book · August 25, 2011 Cite

Mind Out of Body (vol 304, pg 80, 2011)

Journal Article SCIENTIFIC AMERICAN · June 1, 2011 Link to item Cite

Impaired limbic gamma oscillatory synchrony during anxiety-related behavior in a genetic mouse model of bipolar mania.

Journal Article J Neurosci · April 27, 2011 Alterations in anxiety-related processing are observed across many neuropsychiatric disorders, including bipolar disorder. Though polymorphisms in a number of circadian genes confer risk for this disorder, little is known about how changes in circadian gen ... Full text Link to item Cite

Mind out of body.

Journal Article Sci Am · February 2011 Full text Link to item Cite

Chronic in vivo multi-circuit neurophysiological recordings in mice.

Journal Article J Neurosci Methods · January 30, 2011 While genetically modified mice have become a widely accepted tool for modeling the influence of gene function on the manifestation of neurological and psychiatric endophenotypes, only modest headway has been made in characterizing the functional circuit c ... Full text Link to item Cite

Intravascular food reward.

Journal Article PLoS One · 2011 Consumption of calorie-containing sugars elicits appetitive behavioral responses and dopamine release in the ventral striatum, even in the absence of sweet-taste transduction machinery. However, it is unclear if such reward-related postingestive effects re ... Full text Link to item Cite

Cortical correlates of fitts' law.

Journal Article Front Integr Neurosci · 2011 Fitts' law describes the fundamental trade-off between movement accuracy and speed: it states that the duration of reaching movements is a function of target size (TS) and distance. While Fitts' law has been extensively studied in ergonomics and has guided ... Full text Link to item Cite

Comprehensive analysis of tissue preservation and recording quality from chronic multielectrode implants.

Journal Article PLoS One · 2011 Multielectrodes have been used with great success to simultaneously record the activity of neuronal populations in awake, behaving animals. In particular, there is great promise in the use of this technique to allow the control of neuroprosthetic devices b ... Full text Link to item Cite

Toward a whole-body neuroprosthetic.

Journal Article Prog Brain Res · 2011 Brain-machine interfaces (BMIs) hold promise for the restoration of body mobility in patients suffering from devastating motor deficits caused by brain injury, neurological diseases, and limb loss. Considerable progress has been achieved in BMIs that enact ... Full text Link to item Cite

Future developments in brain-machine interface research.

Journal Article Clinics (Sao Paulo) · 2011 Neuroprosthetic devices based on brain-machine interface technology hold promise for the restoration of body mobility in patients suffering from devastating motor deficits caused by brain injury, neurologic diseases and limb loss. During the last decade, c ... Full text Link to item Cite

Neuronal assembly detection and cell membership specification by principal component analysis.

Journal Article PLoS One · 2011 In 1949, Donald Hebb postulated that assemblies of synchronously activated neurons are the elementary units of information processing in the brain. Despite being one of the most influential theories in neuroscience, Hebb's cell assembly hypothesis only sta ... Full text Link to item Cite

Gustatory and reward brain circuits in the control of food intake.

Journal Article Adv Tech Stand Neurosurg · 2011 Gustation is a multisensory process allowing for the selection of nutrients and the rejection of irritating and/or toxic compounds. Since obesity is a highly prevalent condition that is critically dependent on food intake and energy expenditure, a deeper u ... Full text Link to item Cite

Gut-brain interactions and dopamine release

Conference CHEMICAL SENSES · January 1, 2011 Link to item Cite

Lithium ameliorates nucleus accumbens phase-signaling dysfunction in a genetic mouse model of mania.

Journal Article J Neurosci · December 1, 2010 Polymorphisms in circadian genes such as CLOCK convey risk for bipolar disorder. While studies have begun to elucidate the molecular mechanism whereby disruption of Clock alters cellular function within mesolimbic brain regions, little remains known about ... Full text Link to item Cite

Spike avalanches exhibit universal dynamics across the sleep-wake cycle.

Journal Article PLoS One · November 30, 2010 BACKGROUND: Scale-invariant neuronal avalanches have been observed in cell cultures and slices as well as anesthetized and awake brains, suggesting that the brain operates near criticality, i.e. within a narrow margin between avalanche propagation and exti ... Full text Open Access Link to item Cite

Spatiotemporal coupling between hippocampal acetylcholine release and theta oscillations in vivo.

Journal Article J Neurosci · October 6, 2010 Both acetylcholine (ACh) and theta oscillations are important for learning and memory, but the dynamic interaction between these two processes remains unclear. Recent advances in amperometry techniques have revealed phasic ACh releases in vivo. However, it ... Full text Link to item Cite

Restoration of locomotive function in Parkinson's disease by spinal cord stimulation: mechanistic approach.

Journal Article Eur J Neurosci · October 2010 Specific motor symptoms of Parkinson's disease (PD) can be treated effectively with direct electrical stimulation of deep nuclei in the brain. However, this is an invasive procedure, and the fraction of eligible patients is rather low according to currentl ... Full text Link to item Cite

Changes in S1 neural responses during tactile discrimination learning.

Journal Article J Neurophysiol · July 2010 In freely moving rats that are actively performing a discrimination task, single-unit responses in primary somatosensory cortex (S1) are strikingly different from responses to comparable tactile stimuli in immobile rats. For example, in the active discrimi ... Full text Link to item Cite

Noradrenergic control of cortico-striato-thalamic and mesolimbic cross-structural synchrony.

Journal Article J Neurosci · May 5, 2010 Although normal dopaminergic tone has been shown to be essential for the induction of cortico-striatal and mesolimbic theta oscillatory activity, the influence of norepinephrine on these brain networks remains relatively unknown. To address this question, ... Full text Link to item Cite

Coherence potentials: loss-less, all-or-none network events in the cortex.

Journal Article PLoS Biol · January 12, 2010 Transient associations among neurons are thought to underlie memory and behavior. However, little is known about how such associations occur or how they can be identified. Here we recorded ongoing local field potential (LFP) activity at multiple sites with ... Full text Open Access Link to item Cite

Licking-induced synchrony in the taste-reward circuit improves cue discrimination during learning.

Journal Article J Neurosci · January 6, 2010 Animals learn which foods to ingest and which to avoid. Despite many studies, the electrophysiological correlates underlying this behavior at the gustatory-reward circuit level remain poorly understood. For this reason, we measured the simultaneous electri ... Full text Link to item Cite

Activation of frontal neocortical areas by vocal production in marmosets.

Journal Article Front Integr Neurosci · 2010 Primates often rely on vocal communication to mediate social interactions. Although much is known about the acoustic structure of primate vocalizations and the social context in which they are usually uttered, our knowledge about the neocortical control of ... Full text Link to item Cite

Spontaneous cortical activity in awake monkeys composed of neuronal avalanches.

Journal Article Proc Natl Acad Sci U S A · September 15, 2009 Spontaneous neuronal activity is an important property of the cerebral cortex but its spatiotemporal organization and dynamical framework remain poorly understood. Studies in reduced systems--tissue cultures, acute slices, and anesthetized rats--show that ... Full text Link to item Cite

Taste-guided decisions differentially engage neuronal ensembles across gustatory cortices.

Journal Article J Neurosci · September 9, 2009 Much remains to be understood about the differential contributions from primary and secondary sensory cortices to sensory-guided decision making. To address this issue we simultaneously recorded activity from neuronal ensembles in primary [gustatory cortex ... Full text Link to item Cite

Robust Satisficing Linear Regression: performance/robustness trade-off and consistency criterion.

Journal Article Mech Syst Signal Process · August 2009 Linear regression quantifies the linear relationship between paired sets of input and output observations. The well known least-squares regression optimizes the performance criterion defined by the residual error, but is highly sensitive to uncertainties o ... Full text Link to item Cite

Remote control of neuronal activity in transgenic mice expressing evolved G protein-coupled receptors.

Journal Article Neuron · July 16, 2009 Examining the behavioral consequences of selective CNS neuronal activation is a powerful tool for elucidating mammalian brain function in health and disease. Newly developed genetic, pharmacological, and optical tools allow activation of neurons with exqui ... Full text Link to item Cite

Unscented Kalman filter for brain-machine interfaces.

Journal Article PLoS One · July 15, 2009 Brain machine interfaces (BMIs) are devices that convert neural signals into commands to directly control artificial actuators, such as limb prostheses. Previous real-time methods applied to decoding behavioral commands from the activity of populations of ... Full text Link to item Cite

Principles of neural ensemble physiology underlying the operation of brain-machine interfaces.

Journal Article Nat Rev Neurosci · July 2009 Research on brain-machine interfaces has been ongoing for at least a decade. During this period, simultaneous recordings of the extracellular electrical activity of hundreds of individual neurons have been used for direct, real-time control of various arti ... Full text Link to item Cite

Hyperdopaminergia and NMDA receptor hypofunction disrupt neural phase signaling.

Journal Article J Neurosci · June 24, 2009 Neural phase signaling has gained attention as a putative coding mechanism through which the brain binds the activity of neurons across distributed brain areas to generate thoughts, percepts, and behaviors. Neural phase signaling has been shown to play a r ... Full text Link to item Cite

Three-dimensional, automated, real-time video system for tracking limb motion in brain-machine interface studies.

Journal Article J Neurosci Methods · June 15, 2009 Collection and analysis of limb kinematic data are essential components of the study of biological motion, including research into biomechanics, kinesiology, neurophysiology and brain-machine interfaces (BMIs). In particular, BMI research requires advanced ... Full text Link to item Cite

Acquiring local field potential information from amperometric neurochemical recordings.

Journal Article J Neurosci Methods · May 15, 2009 Simultaneous acquisition of in vivo electrophysiological and neurochemical information is essential for understanding how endogenous neurochemicals modulate the dynamics of brain activity. However, up to now such a task has rarely been accomplished due to ... Full text Link to item Cite

A fully implantable 96-channel neural data acquisition system.

Journal Article J Neural Eng · April 2009 A fully implantable neural data acquisition system is a key component of a clinically viable brain-machine interface. This type of system must communicate with the outside world and obtain power without the use of wires that cross through the skin. We pres ... Full text Link to item Cite

Spinal cord stimulation restores locomotion in animal models of Parkinson's disease.

Journal Article Science · March 20, 2009 Dopamine replacement therapy is useful for treating motor symptoms in the early phase of Parkinson's disease, but it is less effective in the long term. Electrical deep-brain stimulation is a valuable complement to pharmacological treatment but involves a ... Full text Link to item Cite

Nicotine activates TRPM5-dependent and independent taste pathways.

Journal Article Proc Natl Acad Sci U S A · February 3, 2009 The orosensory responses elicited by nicotine are relevant for the development and maintenance of addiction to tobacco products. However, although nicotine is described as bitter tasting, the molecular and neural substrates encoding the taste of nicotine a ... Full text Link to item Cite

A brain-machine interface instructed by direct intracortical microstimulation.

Journal Article Front Integr Neurosci · 2009 Brain-machine interfaces (BMIs) establish direct communication between the brain and artificial actuators. As such, they hold considerable promise for restoring mobility and communication in patients suffering from severe body paralysis. To achieve this en ... Full text Link to item Cite

Extracting kinematic parameters for monkey bipedal walking from cortical neuronal ensemble activity.

Journal Article Front Integr Neurosci · 2009 The ability to walk may be critically impacted as the result of neurological injury or disease. While recent advances in brain-machine interfaces (BMIs) have demonstrated the feasibility of upper-limb neuroprostheses, BMIs have not been evaluated as a mean ... Full text Link to item Cite

Series preface

Book · January 1, 2009 Cite

Series preface

Book · January 1, 2009 Cite

Series preface

Book · January 1, 2009 Cite

Persistent hyperdopaminergia decreases the peak frequency of hippocampal theta oscillations during quiet waking and REM sleep.

Journal Article PLoS One · 2009 Long-term changes in dopaminergic signaling are thought to underlie the pathophysiology of a number of psychiatric disorders. Several conditions are associated with cognitive deficits such as disturbances in attention processes and learning and memory, sug ... Full text Link to item Cite

Sleep and sleep states: Network reactivation

Journal Article · January 1, 2009 Network reactivation is a key neural property for the generation of innate and learned behavior. The activation of recurrent anatomical loops underlies the different rhythms produced by the brain, characterizing the distinct global states that comprise wak ... Full text Cite

Genes, sleep and dreams

Journal Article · December 1, 2008 This Chapter considers the continuing debate regarding the mechanisms that underlie the cognitive role of sleep. One theory proposes that the triggering of generalized synaptic downscaling occurs so as to restore homeostatic balance and enable further waki ... Full text Cite

Neuronal ensemble bursting in the basal forebrain encodes salience irrespective of valence.

Journal Article Neuron · July 10, 2008 Both reward- and punishment-related stimuli are motivationally salient and attract the attention of animals. However, it remains unclear how motivational salience is processed in the brain. Here, we show that both reward- and punishment-predicting stimuli ... Full text Link to item Cite

Multisensory Processing of Gustatory Stimuli.

Conference Chemosens Percept · June 2008 Gustatory perception is inherently multimodal, since approximately the same time that intra-oral stimuli activate taste receptors, somatosensory information is concurrently sent to the CNS. We review evidence that gustatory perception is intrinsically link ... Full text Link to item Cite

Food reward in the absence of taste receptor signaling.

Journal Article Neuron · March 27, 2008 Food palatability and hedonic value play central roles in nutrient intake. However, postingestive effects can influence food preferences independently of palatability, although the neurobiological bases of such mechanisms remain poorly understood. Of centr ... Full text Link to item Cite

Brazil's option for science education.

Journal Article Sci Am · February 2008 Link to item Cite

Series preface

Book · January 1, 2008 Cite

Decoding of temporal intervals from cortical ensemble activity.

Journal Article J Neurophysiol · January 2008 Neurophysiological, neuroimaging, and lesion studies point to a highly distributed processing of temporal information by cortico-basal ganglia-thalamic networks. However, there are virtually no experimental data on the encoding of behavioral time by simult ... Full text Link to item Cite

Brazil's option for science education

Journal Article Scientific American · January 1, 2008 Full text Cite

Twenty-Five Years of Multielectrode Recordings in the Somatosensory System: It is All about Dynamics

Journal Article · January 1, 2008 Chronic multielectrode recording methods introduced 25 years ago have opened up the opportunity to simultaneously sample the activity of neurons at multiple levels of the somatosensory system while rats engage in active tactile behaviors. This chapter focu ... Full text Cite

Behavioral and neural responses to gustatory stimuli delivered non-contingently through intra-oral cannulas.

Journal Article Physiol Behav · November 23, 2007 The act of eating requires a decision by an animal to place food in its mouth. The reasons to eat are varied and include hunger as well as the food's expected reward value. Previous studies of tastant processing in the rat primary gustatory cortex (GC) hav ... Full text Link to item Cite

Processing of tactile information by the hippocampus.

Journal Article Proc Natl Acad Sci U S A · November 13, 2007 The ability to detect unusual events occurring in the environment is essential for survival. Several studies have pointed to the hippocampus as a key brain structure in novelty detection, a claim substantiated by its wide access to sensory information thro ... Full text Link to item Cite

Ensembles of gustatory cortical neurons anticipate and discriminate between tastants in a single lick.

Journal Article Front Neurosci · November 2007 The gustatory cortex (GC) processes chemosensory and somatosensory information and is involved in learning and anticipation. Previously we found that a subpopulation of GC neurons responded to tastants in a single lick (Stapleton et al., 2006). Here we ext ... Full text Link to item Cite

Novel experience induces persistent sleep-dependent plasticity in the cortex but not in the hippocampus.

Journal Article Front Neurosci · November 2007 Episodic and spatial memories engage the hippocampus during acquisition but migrate to the cerebral cortex over time. We have recently proposed that the interplay between slow-wave (SWS) and rapid eye movement (REM) sleep propagates recent synaptic changes ... Full text Link to item Cite

Neuronal activity in the primary somatosensory thalamocortical loop is modulated by reward contingency during tactile discrimination.

Journal Article J Neurosci · September 26, 2007 Delayed-response sensory discrimination is believed to require primary sensory thalamus and cortex for early stimulus identification and higher-order forebrain regions for the late association of stimuli with rewarded motor responses. Here we investigate n ... Full text Link to item Cite

The muscle activation method: an approach to impedance control of brain-machine interfaces through a musculoskeletal model of the arm.

Journal Article IEEE Trans Biomed Eng · August 2007 Current demonstrations of brain-machine interfaces (BMIs) have shown the potential for controlling neuroprostheses under pure motion control. For interaction with objects, however, pure motion control lacks the information required for versatile manipulati ... Full text Link to item Cite

Cortical modulations increase in early sessions with brain-machine interface.

Journal Article PLoS One · July 18, 2007 BACKGROUND: During planning and execution of reaching movements, the activity of cortical motor neurons is modulated by a diversity of motor, sensory, and cognitive signals. Brain-machine interfaces (BMIs) extract part of these modulations to directly cont ... Full text Link to item Cite

Dopamine levels modulate the updating of tastant values.

Journal Article Genes Brain Behav · June 2007 To survive, animals must constantly update the internal value of stimuli they encounter; a process referred to as incentive learning. Although there have been many studies investigating whether dopamine is necessary for reward, or for the association betwe ... Full text Link to item Cite

Primate reaching cued by multichannel spatiotemporal cortical microstimulation.

Journal Article J Neurosci · May 23, 2007 Both humans and animals can discriminate signals delivered to sensory areas of their brains using electrical microstimulation. This opens the possibility of creating an artificial sensory channel that could be implemented in neuroprosthetic devices. Althou ... Full text Link to item Cite

Cortical responses to the post-ingestive effects of sucrose in TRPM5-/- mice

Conference INTERNATIONAL JOURNAL OF OBESITY · May 1, 2007 Link to item Cite

Methods for neural ensemble recordings, second edition

Book · January 1, 2007 In the last ten years neural ensemble recording grew into a well-respected and highly data-lucrative science. New experimental paradigms, including the fabrication of high-density microelectrodes, new surgical implantation techniques, multi-channel signal ... Cite

Conceptual and technical approaches to human neural ensemble recordings

Chapter · January 1, 2007 The ability to perform either multineuron or local field/EEG recordings from the nervous system is a critical requirement to develop a new generation of neuroprosthetics that can sense the brain’s intent for action (Nicolelis 2001, 2003). This form of sens ... Cite

Preface

Book · January 1, 2007 Cite

State-of-the-art microwire array design for chronic neural recordings in behaving animals

Chapter · January 1, 2007 Over the last two decades, many laboratories around the world have started to rely on microelectrode arrays formed by ne microwires, organized in different geometrical congurations, to chronically record the extracellular activity of populations of individ ... Cite

Series preface

Book · January 1, 2007 Cite

Series preface

Book · January 1, 2007 Cite

Building brain-machine interfaces to restore neurological functions

Chapter · January 1, 2007 Modern research on brain-machine interfaces (BMI) is a highly multidisciplinary field that has been developing at a stunning pace since the first experiment conducted 8 years ago that demonstrated direct control of a robotic manipulator by ensembles of neu ... Cite

Neural ensemble recordings from central gustatory-reward pathways in awake and behaving animals

Chapter · January 1, 2007 The mammalian gustatory system participates in the detection and discrimination of intraoral stimuli, allowing for the selection of nutrients and rejection of toxic compounds. However, the sensory percept of a substance that is placed in the mouth does not ... Cite

Prediction of motor timing using nonlinear analysis of local field potentials

Conference IFMBE Proceedings · January 1, 2007 Recently we have shown that temporal intervals preceding movement onset in a self-timed motor task can be accurately predicted from the ensembles activity of cortical neurons recorded in motor and premotor cortex. The aim of this study was to predict behav ... Full text Cite

The evolution of neural systems for sleep and dreaming

Journal Article · January 1, 2007 Despite the importance of sleep and dreams for the understanding of human consciousness, science is yet to achieve a consensus about their functions and intricate phenomenology. This article outlines an evolutionary theory of how sleep and dreams were sele ... Full text Cite

Evolution of gustation

Journal Article · January 1, 2007 The evolutionary success of most mammalian species results in part from their ability to efficiently select nutrients in order to maintain energy, fluid and temperature homeostasis. It is shown that efficient ingestive behavior depends on several structure ... Full text Cite

Fast modulation of prefrontal cortex activity by basal forebrain noncholinergic neuronal ensembles.

Journal Article J Neurophysiol · December 2006 Traditionally, most basal forebrain (BF) functions have been attributed to its cholinergic neurons. However, the majority of cortical-projecting BF neurons are noncholinergic and their in vivo functions remain unclear. We investigated how BF modulates cort ... Full text Link to item Cite

Seeking the neural code.

Journal Article Sci Am · December 2006 Full text Link to item Cite

An INFO-GAP approach to linear regression

Journal Article ICASSP, IEEE International Conference on Acoustics, Speech and Signal Processing - Proceedings · December 1, 2006 Linear regression with high uncertainties in the measurements, model structure and model permanence is a major challenging problem. Standard regression techniques are based on optimizing a certain performance criterion, usually the mean squared error, and ... Cite

The neural mechanisms of gustation: a distributed processing code.

Journal Article Nat Rev Neurosci · November 2006 Whenever food is placed in the mouth, taste receptors are stimulated. Simultaneously, different types of sensory fibre that monitor several food attributes such as texture, temperature and odour are activated. Here, we evaluate taste and oral somatosensory ... Full text Link to item Cite

Rapid alterations in corticostriatal ensemble coordination during acute dopamine-dependent motor dysfunction.

Journal Article Neuron · October 19, 2006 Dopaminergic dysregulation can cause motor dysfunction, but the mechanisms underlying dopamine-related motor disorders remain under debate. We used an inducible and reversible pharmacogenetic approach in dopamine transporter knockout mice to investigate th ... Full text Link to item Cite

Dopaminergic control of sleep-wake states.

Journal Article J Neurosci · October 11, 2006 Dopamine depletion is involved in the pathophysiology of Parkinson's disease, whereas hyperdopaminergia may play a fundamental role in generating endophenotypes associated with schizophrenia. Sleep disturbances are known to occur in both schizophrenia and ... Full text Link to item Cite

Brain-machine interfaces: past, present and future.

Journal Article Trends Neurosci · September 2006 Since the original demonstration that electrical activity generated by ensembles of cortical neurons can be employed directly to control a robotic manipulator, research on brain-machine interfaces (BMIs) has experienced an impressive growth. Today BMIs des ... Full text Link to item Cite

Neural ensemble coding of satiety states.

Journal Article Neuron · August 17, 2006 The motivation to start or terminate a meal involves the continual updating of information on current body status by central gustatory and reward systems. Previous electrophysiological and neuroimaging investigations revealed region-specific decreases in a ... Full text Link to item Cite

Continuous shared control for stabilizing reaching and grasping with brain-machine interfaces.

Journal Article IEEE Trans Biomed Eng · June 2006 Research on brain-machine interfaces (BMI's) is directed toward enabling paralyzed individuals to manipulate their environment through slave robots. Even for able-bodied individuals, using a robot to reach and grasp objects in unstructured environments can ... Full text Link to item Cite

A comparison of optimal MIMO linear and nonlinear models for brain-machine interfaces.

Journal Article J Neural Eng · June 2006 The field of brain-machine interfaces requires the estimation of a mapping from spike trains collected in motor cortex areas to the hand kinematics of the behaving animal. This paper presents a systematic investigation of several linear (Wiener filter, LMS ... Full text Link to item Cite

Rapid taste responses in the gustatory cortex during licking.

Journal Article J Neurosci · April 12, 2006 Rapid tastant detection is necessary to prevent the ingestion of potentially poisonous compounds. Behavioral studies have shown that rats can identify tastants in approximately 200 ms, although the electrophysiological correlates for fast tastant detection ... Full text Link to item Cite

Series preface

Book · January 1, 2006 Full text Cite

Series preface

Book · January 1, 2006 Cite

Independently coupled HMM switching classifier for a bimodel brain-machine interface

Journal Article Proceedings of the 2006 16th IEEE Signal Processing Society Workshop on Machine Learning for Signal Processing, MLSP 2006 · January 1, 2006 Our initial attempt to develop a switching classifier used vector quantization to compress the multi-dimensional neural data recorded from multiple cortical areas of an owl monkey, into a discrete symbol for use in a single Hidden Markov Model (HMM) or HMM ... Full text Cite

Orbitofrontal ensemble activity monitors licking and distinguishes among natural rewards.

Journal Article J Neurophysiol · January 2006 The classification of rhythmic licking into clusters has proved to be useful for characterizing brain mechanisms that modulate the ingestion of natural rewards (sucrose and water). One cortical area that is responsive to rewarding stimuli is the orbitofron ... Full text Link to item Cite

An info-gap approach to linear regression

Conference 2006 IEEE INTERNATIONAL CONFERENCE ON ACOUSTICS, SPEECH AND SIGNAL PROCESSING, VOLS 1-13 · January 1, 2006 Link to item Cite

Determining patterns in neural activity for reaching movements using nonnegative matrix factorization

Journal Article Eurasip Journal on Applied Signal Processing · December 1, 2005 We propose the use of nonnegative matrix factorization (NMF) as a model-independent methodology to analyze neural activity. We demonstrate that, using this technique, it is possible to identify local spatiotemporal patterns of neural activity in the form o ... Full text Cite

Multiresolution representations and data mining of neural spikes for brain-machine interfaces

Journal Article 2nd International IEEE EMBS Conference on Neural Engineering · December 1, 2005 In brain-machine interface (BMI) applications, neural firing activities have been represented by spike counts with a fixed-width time bin. Adaptive models have been designed to utilize these bin counts for mapping the associated behavior which is typically ... Full text Cite

Stable ensemble performance with single-neuron variability during reaching movements in primates.

Journal Article J Neurosci · November 16, 2005 Significant variability in firing properties of individual neurons was observed while two monkeys, chronically implanted with multielectrode arrays in frontal and parietal cortical areas, performed a continuous arm movement task. Although the degree of cor ... Full text Link to item Cite

Frontal and parietal cortical ensembles predict single-trial muscle activity during reaching movements in primates.

Journal Article Eur J Neurosci · September 2005 Previously we have shown that the kinematic parameters of reaching movements can be extracted from the activity of cortical ensembles. Here we used cortical ensemble activity to predict electromyographic (EMG) signals of four arm muscles in New World monke ... Full text Link to item Cite

Computing with thalamocortical ensembles during different behavioural states.

Journal Article J Physiol · July 1, 2005 A series of recent studies have indicated that ensembles of neurones, distributed within the neural structures that form the primary thalamocortical loop (TCL) of the trigeminal component of the rat somatosensory system, change the way they respond to simi ... Full text Link to item Cite

Interpreting spatial and temporal neural activity through a recurrent neural network brain-machine interface.

Journal Article IEEE Trans Neural Syst Rehabil Eng · June 2005 We propose the use of optimized brain-machine interface (BMI) models for interpreting the spatial and temporal neural activity generated in motor tasks. In this study, a nonlinear dynamical neural network is trained to predict the hand position of primates ... Full text Link to item Cite

Cortical ensemble adaptation to represent velocity of an artificial actuator controlled by a brain-machine interface.

Journal Article J Neurosci · May 11, 2005 Monkeys can learn to directly control the movements of an artificial actuator by using a brain-machine interface (BMI) driven by the activity of a sample of cortical neurons. Eventually, they can do so without moving their limbs. Neuronal adaptations under ... Full text Link to item Cite

Heterogeneous integration of bilateral whisker signals by neurons in primary somatosensory cortex of awake rats.

Journal Article J Neurophysiol · May 2005 Bilateral single-unit recordings in primary somatosensory cortex (S1) of anesthetized rats have revealed substantial cross talk between cortical hemispheres, suggesting the possibility that behaviorally relevant bilateral integration could occur in S1. To ... Full text Link to item Cite

Series Preface

Book · January 1, 2005 Cite

Learning mappings in brain machine interfaces with echo state networks

Journal Article ICASSP, IEEE International Conference on Acoustics, Speech and Signal Processing - Proceedings · January 1, 2005 Brain Machine Interfaces (BMI) utilize linear or non-linear models to map the neural activity to the associated behavior which is typically the 2-D or 3-D hand position of a primate. Linear models are plagued by the massive disparity of the input and outpu ... Full text Cite

Global forebrain dynamics predict rat behavioral states and their transitions.

Journal Article J Neurosci · December 8, 2004 The wake-sleep cycle, a spontaneous succession of global brain states that correspond to major overt behaviors, occurs in all higher vertebrates. The transitions between these states, at once rapid and drastic, remain poorly understood. Here, intracranial ... Full text Link to item Cite

Differential corticostriatal plasticity during fast and slow motor skill learning in mice.

Journal Article Curr Biol · July 13, 2004 BACKGROUND: Motor skill learning usually comprises "fast" improvement in performance within the initial training session and "slow" improvement that develops across sessions. Previous studies have revealed changes in activity and connectivity in motor cort ... Full text Link to item Cite

Ensemble recordings of human subcortical neurons as a source of motor control signals for a brain-machine interface.

Journal Article Neurosurgery · July 2004 OBJECTIVE: Patients with severe neurological injury, such as quadriplegics, might benefit greatly from a brain-machine interface that uses neuronal activity from motor centers to control a neuroprosthetic device. Here, we report an implementation of this s ... Link to item Cite

Layer-specific somatosensory cortical activation during active tactile discrimination.

Journal Article Science · June 25, 2004 Ensemble neuronal activity was recorded in each layer of the whisker area of the primary somatosensory cortex (SI) while rats performed a whisker-dependent tactile discrimination task. Comparison of this activity with SI activity evoked by similar passive ... Full text Link to item Cite

Transmission latencies in a telemetry-linked brain-machine interface.

Journal Article IEEE Trans Biomed Eng · June 2004 To be clinically viable, a brain-machine interface (BMI) requires transcutaneous telemetry. Spike-based compression algorithms can be used to reduce the amount of telemetered data, but this type of system is subject to queuing-based transmission delays. Th ... Full text Link to item Cite

Special issue on brain-machine interfaces: Editorial

Journal Article IEEE Transactions on Biomedical Engineering · June 1, 2004 Full text Cite

Ascertaining the importance of neurons to develop better brain-machine interfaces.

Journal Article IEEE Trans Biomed Eng · June 2004 In the design of brain-machine interface (BMI) algorithms, the activity of hundreds of chronically recorded neurons is used to reconstruct a variety of kinematic variables. A significant problem introduced with the use of neural ensemble inputs for model b ... Full text Link to item Cite

Reduction of single-neuron firing uncertainty by cortical ensembles during motor skill learning.

Journal Article J Neurosci · April 7, 2004 Motor skill learning is usually characterized by shortening of response time and performance of faster, more stereotypical movements. However, little is known about the changes in neural activity that underlie these behavioral changes. Here we used chronic ... Full text Link to item Cite

A multichannel telemetry system for single unit neural recordings.

Journal Article J Neurosci Methods · February 15, 2004 We present the design, testing, and evaluation of a 16 channel wearable telemetry system to facilitate multichannel single unit recordings from freely moving test subjects. Our design is comprised of (1) a 16-channel analog front end board to condition and ... Full text Link to item Cite

A low power multichannel analog front end for portable neural signal recordings.

Journal Article J Neurosci Methods · February 15, 2004 We present the design and testing of a 16-channel analog amplifier for processing neural signals. Each channel has the following features: (1) variable gain (70-94 dB), (2) four high pass Bessel filter poles (f(-3 dB)=445 Hz), (3) five low pass Bessel filt ... Full text Link to item Cite

Neuroprosthetics and clinical realization of brain-machine interfaces

Chapter · January 1, 2004 Neuroprosthetics encompasses a wide variety of interfaces with the nervous system, usually considered in the context of clinical abnormalities or disease. The concept stems from clinical concerns about functional independence and integration of individuals ... Cite

Pre-ictal seizure detection and demand treatment strategies for epilepsy

Chapter · January 1, 2004 Mechanisms of epilepsy have been explored through a variety of animal models as well as detailed human studies, for more than 70 years.1-3 Through the animal models, a large number of contributing factors leading to epilepsy have been demonstrated, includi ... Cite

Advances in brain-machine interfaces

Chapter · January 1, 2004 Throughout history, the introduction of new technologies has significantly impacted human life in many different ways. Until now, however, each new artificial device or tool designed to enhance human motor, sensory, or cognitive capabilities has relied on ... Cite

Neuronal reverberation and the consolidation of new memories across the wake-sleep cycle

Chapter · January 1, 2004 In mammals and birds, long episodes of nondreaming sleep (slow-wave sleep, SW) are followed by short episodes of dreaming sleep (rapid-eye-movement sleep, REM). ... Cite

Reverberation, storage, and postsynaptic propagation of memories during sleep.

Journal Article Learn Mem · 2004 In mammals and birds, long episodes of nondreaming sleep ("slow-wave" sleep, SW) are followed by short episodes of dreaming sleep ("rapid-eye-movement" sleep, REM). Both SW and REM sleep have been shown to be important for the consolidation of newly acquir ... Full text Link to item Cite

Optimizing a linear algorithm for real-time robotic control using chronic cortical ensemble recordings in monkeys.

Journal Article J Cogn Neurosci · 2004 Previous work in our laboratory has demonstrated that a simple linear model can be used to translate cortical neuronal activity into real-time motor control commands that allow a robot arm to mimic the intended hand movements of trained primates. Here, we ... Full text Link to item Cite

Long-lasting novelty-induced neuronal reverberation during slow-wave sleep in multiple forebrain areas.

Journal Article PLoS Biol · January 2004 The discovery of experience-dependent brain reactivation during both slow-wave (SW) and rapid eye-movement (REM) sleep led to the notion that the consolidation of recently acquired memory traces requires neural replay during sleep. To date, however, severa ... Full text Link to item Cite

Simultaneus prediction of four kinematic variables for a brain-machine interface using a single recurrent neural network.

Journal Article Conf Proc IEEE Eng Med Biol Soc · 2004 Implementation of brain-machine interface neural-to-motor mapping algorithms in low-power, portable digital signal processors (DSPs) requires efficient use of model resources especially when predicting signals that show interdependencies. We show here that ... Full text Link to item Cite

Bimodal Brain-Machine Interface for Motor Control of Robotic Prosthetic

Journal Article IEEE International Conference on Intelligent Robots and Systems · December 26, 2003 We are working on mapping multi-channel neural spike data, recorded from multiple cortical areas of an owl monkey, to corresponding 3d monkey arm positions. In earlier work on this mapping task, we observed that continuous function approximators (such as a ... Cite

Interpreting Neural Activity Through Linear and Nonlinear Models for Brain Machine Interfaces

Journal Article Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings · December 1, 2003 Brain machine interface (BMI) design can be achieved by training linear and nonlinear models with simultaneously recorded cortical neural activity and behavior (typically the hand position of a primate). We propose the use of optimized BMI models for analy ... Cite

Learning to control a brain-machine interface for reaching and grasping by primates.

Journal Article PLoS Biol · November 2003 Reaching and grasping in primates depend on the coordination of neural activity in large frontoparietal ensembles. Here we demonstrate that primates can learn to reach and grasp virtual objects by controlling a robot arm through a closed-loop brain-machine ... Full text Link to item Cite

Modeling the Relation from Motor Cortical Neuronal Firing to Hand Movements Using Competitive Linear Filters and a MLP

Journal Article Proceedings of the International Joint Conference on Neural Networks · September 24, 2003 Recent research has demonstrated that linear models are able to estimate hand positions using populations of action potentials collected in the pre-motor and motor cortical areas of a primate's brain. One of the applications of this result is to restore mo ... Cite

Chronic, multisite, multielectrode recordings in macaque monkeys.

Journal Article Proc Natl Acad Sci U S A · September 16, 2003 A paradigm is described for recording the activity of single cortical neurons from awake, behaving macaque monkeys. Its unique features include high-density microwire arrays and multichannel instrumentation. Three adult rhesus monkeys received microwire ar ... Full text Link to item Cite

Behavioral detection of tactile stimuli during 7-12 Hz cortical oscillations in awake rats.

Journal Article Nat Neurosci · September 2003 Prominent 7-12 Hz oscillations in the primary somatosensory cortex (S1) of awake but immobile rats might represent a seizure-like state in which neuronal burst firing renders animals unresponsive to incoming tactile stimuli; others have proposed that these ... Full text Link to item Cite

Interval timing and the encoding of signal duration by ensembles of cortical and striatal neurons.

Journal Article Behav Neurosci · August 2003 This study investigated the firing patterns of striatal and cortical neurons in rats in a temporal generalization task. Striatal and cortical ensembles were recorded in rats trained to lever press at 2 possible criterion durations (10 s or 40 s from tone o ... Full text Link to item Cite

Brain-machine interfaces to restore motor function and probe neural circuits.

Journal Article Nat Rev Neurosci · May 2003 Featured Publication Full text Link to item Cite

Two multichannel integrated circuits for neural recording and signal processing.

Journal Article IEEE Trans Biomed Eng · February 2003 We have developed, manufactured, and tested two analog CMOS integrated circuit "neurochips" for recording from arrays of densely packed neural electrodes. Device A is a 16-channel buffer consisting of parallel noninverting amplifiers with a gain of 2 V/V. ... Full text Link to item Cite

Learning the contributions of the motor, premotor, and posterior parietal cortices for hand trajectory reconstruction in a brain machine interface

Journal Article International IEEE/EMBS Conference on Neural Engineering, NER · January 1, 2003 The ability to record, in real-time, the activity of hundreds of cortical neurons gives the ability to selectively study the function of clusters of cortical neurons in Brain Machine Interface (BMI) experiments. We have demonstrated using a recursive multi ... Full text Cite

Integration of behavior and timing: Anatomically separate systems or distributed processing?

Chapter · January 1, 2003 With the recent development of powerful methods to study brain-behavior relations, the study of interval timing has rapidly shifted from primarily behavioral analyses elucidating the psychological constructs of timing to investigations aimed at identifying ... Cite

Series preface

Book · January 1, 2003 Cite

Series preface

Book · January 1, 2003 Cite

Divide-and-conquer approach for brain machine interfaces: nonlinear mixture of competitive linear models.

Journal Article Neural Netw · 2003 This paper proposes a divide-and-conquer strategy for designing brain machine interfaces. A nonlinear combination of competitively trained local linear models (experts) is used to identify the mapping from neuronal activity in cortical areas associated wit ... Full text Link to item Cite

16-channel neural pre-conditioning device

Conference International IEEE/EMBS Conference on Neural Engineering, NER · January 1, 2003 We present the mixed-signal circuit design, layout, implementation techniques, and test data for a 16-channel neural pre-conditioning device that is used to amplify and filter signals acquired from chronically implanted electrodes in an animal's brain. Sch ... Full text Cite

Dynamic shifting in thalamocortical processing during different behavioural states.

Journal Article Philos Trans R Soc Lond B Biol Sci · December 29, 2002 Recent experiments in our laboratory have indicated that as rats shift the behavioural strategy employed to explore their surrounding environment, there is a parallel change in the physiological properties of the neuronal ensembles that define the main tha ... Full text Link to item Cite

A multichannel CMOS analog front end IC for neural recordings

Journal Article Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings · December 1, 2002 A multichannel integrated circuit for processing extracellular neural signals has been designed and manufactured. The analog CMOS IC consists of 17 parallel channels, each comprised of three cascaded stages: bandpass filter with gain, switched capacitor fi ... Cite

The amazing adventures of robotrat.

Journal Article Trends Cogn Sci · November 1, 2002 Featured Publication By using electrical brain stimulation to deliver both 'virtual' tactile cues and rewards to freely roaming rats, Talwar et al. have been able to instruct animals remotely to navigate through complex mazes and natural environments they have never visited be ... Full text Link to item Cite

Multielectrode recordings: the next steps.

Journal Article Curr Opin Neurobiol · October 2002 Featured Publication At present, a growing number of laboratories are acquiring the capability of simultaneously monitoring the extracellular activity of over a hundred single neurons in both anaesthetized and awake animals. This paradigm, known as multielectrode recordings, i ... Full text Link to item Cite

Controlling robots with the mind.

Journal Article Sci Am · October 2002 Featured Publication Full text Link to item Cite

Gustatory processing is dynamic and distributed.

Journal Article Curr Opin Neurobiol · August 2002 Featured Publication The process of gustatory coding consists of neural responses that provide information about the quantity and quality of food, its generalized sensation, its hedonic value, and whether it should be swallowed. Many of the models presently used to analyze gus ... Full text Link to item Cite

A simulator for the analysis of neuronal ensemble activity: Application to reaching tasks

Journal Article Neurocomputing · July 27, 2002 A biologically based, multi-cortical computational model was developed to investigate how ensembles of neurons learn to execute a three-dimensional reaching task. The model produces outputs of spike trains that can be analyzed using a variety of multivaria ... Full text Cite

Thalamocortical [correction of Thalamcortical] optimization of tactile processing according to behavioral state.

Journal Article Nat Neurosci · June 2002 Featured Publication We propose a conceptual model that describes the operation of the main thalamocortical loop of the rat somatosensory system. According to this model, the asynchronous convergence of ascending and descending projections dynamically alters the physiological ... Full text Link to item Cite

Depression at thalamocortical synapses: the key for cortical neuronal adaptation?

Journal Article Neuron · April 25, 2002 Featured Publication Neuronal adaptation to repetitive sensory stimuli is ubiquitous in the mammalian cortex. Despite its prevalence, the cellular mechanisms underlying this basic physiological property remain a matter of dispute. In this issue of Neuron, Chung et al. provide ... Full text Link to item Cite

Taste-specific neuronal ensembles in the gustatory cortex of awake rats.

Journal Article J Neurosci · March 1, 2002 Featured Publication In gustatory cortex, single-neuron activity reflects the multimodal processing of taste stimuli. Little is known, however, about the interactions between gustatory cortical (GC) neurons during tastant processing. Here, these interactions were characterized ... Full text Link to item Cite

Input-output mapping performance of linear and nonlinear models for estimating hand trajectories from cortical neuronal firing patterns

Conference Neural Networks for Signal Processing - Proceedings of the IEEE Workshop · January 1, 2002 Linear and nonlinear (TDNN) models have been shown to estimate hand position using populations of action potentials collected in the pre-motor and motor cortical areas of a primate's brain. One of the applications of this discovery is to restore movement i ... Full text Cite

Series preface

Book · January 1, 2002 Cite

Series preface

Book · January 1, 2002 Cite

Integration of bilateral whisker stimuli in rats: role of the whisker barrel cortices.

Journal Article Cereb Cortex · January 2002 Featured Publication Recently, we demonstrated that neural responses within the whisker region of the primary somatosensory cortex (SIw) of rats are profoundly influenced by the spatiotemporal attributes of ipsilateral, as well as contralateral, whisker stimuli. As inactivatio ... Full text Link to item Cite

Controlling robots with the mind

Journal Article Sci. Am. (Int. Ed.) (USA) · 2002 People with nerve or limb injuries may one day be able to command wheelchairs, prosthetics and even paralyzed arms and legs by "thinking them through" the motions ... Cite

Thalamic bursting in rats during different awake behavioral states.

Journal Article Proc Natl Acad Sci U S A · December 18, 2001 Featured Publication Thalamic neurons have two firing modes: tonic and bursting. It was originally suggested that bursting occurs only during states such as slow-wave sleep, when little or no information is relayed by the thalamus. However, bursting occurs during wakefulness i ... Full text Link to item Cite

The brain decade in debate: VI. Sensory and motor maps: dynamics and plasticity.

Journal Article Braz J Med Biol Res · December 2001 Featured Publication This article is an edited transcription of a virtual symposium promoted by the Brazilian Society of Neuroscience and Behavior (SBNeC). Although the dynamics of sensory and motor representations have been one of the most studied features of the central nerv ... Full text Link to item Cite

Role of cortical feedback in the receptive field structure and nonlinear response properties of somatosensory thalamic neurons.

Journal Article Exp Brain Res · November 2001 Featured Publication Previous studies have suggested that the descending pathway from the primary somatosensory (SI) cortex to the ventral posterior nucleus of the thalamus has only a mild facilitative influence over thalamic neurons. Given the large numbers of corticothalamic ... Full text Link to item Cite

Techniques for long-term multisite neuronal ensemble recordings in behaving animals.

Journal Article Methods · October 2001 Featured Publication Advances in our understanding of neural systems will go hand in hand with improvements in the experimental techniques used to study these systems. This article describes a series of methodological developments aimed at enhancing the power of the methods ne ... Full text Link to item Cite

Behavioral properties of the trigeminal somatosensory system in rats performing whisker-dependent tactile discriminations.

Journal Article J Neurosci · August 1, 2001 Featured Publication To address several fundamental questions regarding how multiwhisker tactile stimuli are integrated and processed by the trigeminal somatosensory system, a novel behavioral task was developed that required rats to discriminate the width of either a wide or ... Full text Link to item Cite

Bilateral integration of whisker information in the primary somatosensory cortex of rats.

Journal Article J Neurosci · July 15, 2001 Featured Publication The isomorphic representation of the contralateral whisker pad in the rodent cerebral cortex has served as a canonical example in primary somatosensory areas that the contralateral body surface is spatially represented as a topographic map. By characterizi ... Full text Link to item Cite

Dynamic and multimodal responses of gustatory cortical neurons in awake rats.

Journal Article J Neurosci · June 15, 2001 Featured Publication To investigate the dynamic aspects of gustatory activity, we recorded the responses of small ensembles of cortical neurons to tastants administered to awake rats. Multiple trials of each tastant were delivered during recordings made in oral somatosensory ( ... Full text Link to item Cite

Feature article: the structure and function of dynamic cortical and thalamic receptive fields.

Journal Article Cereb Cortex · March 2001 Featured Publication Under natural conditions, animals must process spatiotemporally complex signals in order to guide adaptive behavior. It follows that the response properties of neurons should reflect the dynamic nature of such signals. Recently, several studies have demons ... Full text Link to item Cite

Actions from thoughts.

Journal Article Nature · January 18, 2001 Full text Link to item Cite

A multi-channel whisker stimulator for producing spatiotemporally complex tactile stimuli.

Journal Article J Neurosci Methods · January 15, 2001 Featured Publication A system is described that delivers complex, biologically realistic, tactile stimuli to the rat's facial whisker pad by independently stimulating up to 16 individual facial whiskers in a flexible yet highly controlled and repeatable manner. The system is t ... Full text Link to item Cite

Thalamocortical and corticocortical interactions in the somatosensory system.

Journal Article Prog Brain Res · 2001 Featured Publication Link to item Cite

Advances in neural population coding: Preface

Journal Article Progress in Brain Research · January 1, 2001 Full text Cite

Thalamocortical and corticocortical interactions in the somatosensory system

Journal Article Progress in Brain Research · January 1, 2001 Full text Cite

Real-time prediction of hand trajectory by ensembles of cortical neurons in primates.

Journal Article Nature · November 16, 2000 Signals derived from the rat motor cortex can be used for controlling one-dimensional movements of a robot arm. It remains unknown, however, whether real-time processing of cortical signals can be employed to reproduce, in a robotic device, the kind of com ... Full text Link to item Cite

Reduction of pentylenetetrazole-induced seizure activity in awake rats by seizure-triggered trigeminal nerve stimulation.

Journal Article J Neurosci · November 1, 2000 Stimulation of the vagus nerve has become an effective method for desynchronizing the highly coherent neural activity typically associated with epileptic seizures. This technique has been used in several animal models of seizures as well as in humans suffe ... Full text Link to item Cite

Cortical ensemble activity increasingly predicts behaviour outcomes during learning of a motor task.

Journal Article Nature · June 1, 2000 When an animal learns to make movements in response to different stimuli, changes in activity in the motor cortex seem to accompany and underlie this learning. The precise nature of modifications in cortical motor areas during the initial stages of motor l ... Full text Link to item Cite

Encoding of tactile stimulus location by somatosensory thalamocortical ensembles.

Journal Article J Neurosci · May 15, 2000 The exquisite modular anatomy of the rat somatosensory system makes it an excellent model to test the potential coding strategies used to discriminate the location of a tactile stimulus. Here, we investigated how ensembles of simultaneously recorded single ... Full text Link to item Cite

Designing a brain- machine interface for neuroprosthetic control

Chapter · January 1, 2000 There are roughly four major subassemblies of a brain derived neuroprosthetic control device: (1) the electrodes subassembly, (2) signal conditioning subassembly, (3) signal acquisition subassembly, and (4) transmitter subassemblies (Table 6.1). Notably ab ... Cite

Series Preface

Book · January 1, 2000 Cite

Brain control of sensorimotor prostheses

Chapter · January 1, 2000 The introduction to this volume outlines the possibilities inherent in utilizing electronic interfaces with the brain to alleviate problems of paralysis, such as that caused by spinal cord injury. The possibility of using electroencephalographic recordings ... Cite

Nutrient tasting and signaling mechanisms in the gut. IV. There is more to taste than meets the tongue.

Journal Article Am J Physiol Gastrointest Liver Physiol · January 2000 The tongue is the principal organ that provides sensory information about the quality and quantity of chemicals in food. Other information about the temperature and texture of food is also transduced on the tongue, via extragemmal receptors that form branc ... Full text Link to item Cite

Independent component analyses for quantifying neuronal ensemble interactions.

Journal Article J Neurosci Methods · December 15, 1999 The goal of this study was to compare how multivariate statistical methods for dimension reduction account for correlations between simultaneously recorded neurons. Here, we describe applications of principal component analysis (PCA) and independent compon ... Full text Link to item Cite

Principal component analysis of neuronal ensemble activity reveals multidimensional somatosensory representations.

Journal Article J Neurosci Methods · December 15, 1999 Principal components analysis (PCA) was used to define the linearly dependent factors underlying sensory information processing in the vibrissal sensory area of the ventral posterior medial (VPM) thalamus in eight awake rats. Ensembles of up to 23 single n ... Full text Link to item Cite

Methods for recording and analyzing neuronal ensemble activity

Journal Article JOURNAL OF NEUROSCIENCE METHODS · December 15, 1999 Link to item Cite

Behavioral modulation of tactile responses in the rat somatosensory system.

Journal Article J Neurosci · September 1, 1999 We investigated the influence of four different behavioral states on tactile responses recorded simultaneously via arrays of microwires chronically implanted in the vibrissal representations of the rat ventral posterior medial nucleus (VPM) of the thalamus ... Full text Link to item Cite

Simultaneous reorganization in thalamocortical ensembles evolves over several hours after perioral capsaicin injections.

Journal Article J Neurophysiol · August 1999 Reorganization of the somatosensory system was quantified by simultaneously recording from single-unit neural ensembles in the whisker regions of the ventral posterior medial (VPM) nucleus of the thalamus and the primary somatosensory (SI) cortex in anesth ... Full text Link to item Cite

Immediate thalamic sensory plasticity depends on corticothalamic feedback.

Journal Article Proc Natl Acad Sci U S A · July 6, 1999 Multiple neuron ensemble recordings were obtained simultaneously from both the primary somatosensory (SI) cortex and the ventroposterior medial thalamus (VPM) before and during the combined administration of reversible inactivation of the SI cortex and a r ... Full text Link to item Cite

Real-time control of a robot arm using simultaneously recorded neurons in the motor cortex.

Journal Article Nat Neurosci · July 1999 To determine whether simultaneously recorded motor cortex neurons can be used for real-time device control, rats were trained to position a robot arm to obtain water by pressing a lever. Mathematical transformations, including neural networks, converted mu ... Full text Link to item Cite

Spatiotemporal properties of layer V neurons of the rat primary somatosensory cortex.

Journal Article Cereb Cortex · June 1999 Animals in their natural environments actively process spatiotemporally complex sensory signals in order to guide adaptive behavior. It therefore seems likely that the properties of both single neurons and neural ensembles should reflect the dynamic nature ... Full text Link to item Cite

Editorial

Journal Article Journal of Neuroscience Methods · January 1, 1999 Full text Cite

Simultaneous encoding of tactile information by three primate cortical areas.

Journal Article Nat Neurosci · November 1998 We used simultaneous multi-site neural ensemble recordings to investigate the representation of tactile information in three areas of the primate somatosensory cortex (areas 3b, SII and 2). Small neural ensembles (30-40 neurons) of broadly tuned somatosens ... Full text Link to item Cite

Potential circuit mechanisms underlying concurrent thalamic and cortical plasticity.

Journal Article Rev Neurosci · 1998 During the last two decades, plastic reorganization of both sensory and motor representations in the adult central nervous system has been demonstrated following a large variety of manipulations, ranging from partial lesions of the sensory receptor surface ... Full text Link to item Cite

Topographic and laminar organizations of the incertocortical pathway in rats.

Journal Article Neuroscience · December 1997 The topographic and laminar organizations of the projection system from the zona incerta to the neocortex were studied by using both retrograde and anterograde methods in the rat. Injections of retrograde fluorescent tracers into different cortical areas r ... Full text Link to item Cite

Neonatal whisker removal reduces the discrimination of tactile stimuli by thalamic ensembles in adult rats.

Journal Article J Neurophysiol · September 1997 Simultaneous recordings of up to 48 single neurons per animal were used to characterize the long-term functional effects of sensory plastic modifications in the ventral posterior medial nucleus (VPM) of the thalamus following unilateral removal of facial w ... Full text Link to item Cite

Immediate and simultaneous sensory reorganization at cortical and subcortical levels of the somatosensory system.

Journal Article Proc Natl Acad Sci U S A · August 19, 1997 The occurrence of cortical plasticity during adulthood has been demonstrated using many experimental paradigms. Whether this phenomenon is generated exclusively by changes in intrinsic cortical circuitry, or whether it involves concomitant cortical and sub ... Full text Link to item Cite

Nonlinear processing of tactile information in the thalamocortical loop.

Journal Article J Neurophysiol · July 1997 Rats explore tangible objects in a manner such that, at any given moment in time, multiple facial whiskers simultaneously contact the surface of the object. Although both thalamic and cortical neurons responsible for processing such tactile information hav ... Full text Link to item Cite

Reconstructing the engram: simultaneous, multisite, many single neuron recordings.

Journal Article Neuron · April 1997 Little is known about the physiological principles that govern large-scale neuronal interactions in the mammalian brain. Here, we describe an electrophysiological paradigm capable of simultaneously recording the extracellular activity of large populations ... Full text Link to item Cite

Dynamic and distributed somatosensory representations as the substrate for cortical and subcortical plasticity

Journal Article Seminars in the Neurosciences · January 1, 1997 Seconds after a cutaneous deafferentation is induced in adult animals, a complex process of plastic reorganization is triggered in the subcortical and cortical structures that form the somatosensory system. This process, which leads to the immediate unmask ... Full text Cite

What do dynamic receptive field properties reveal about computation in recurrent thalamocortical circuits?

Conference COMPUTATIONAL NEUROSCIENCE: TRENDS IN RESEARCH, 1997 · January 1, 1997 Link to item Cite

Active tactile exploration influences the functional maturation of the somatosensory system.

Journal Article J Neurophysiol · May 1996 1. The hypothesis that active exploration of objects is required for the functional maturation of neuronal circuits subserving tactile perception was tested by subjecting 8- to 11-day old rats to a complete unilateral section of the facial nerve. This proc ... Full text Link to item Cite

Beyond maps: a dynamic view of the somatosensory system.

Journal Article Braz J Med Biol Res · April 1996 Current theories on how tactile information is processed by the mammalian somatosensory system are based primarily on data obtained in studies in which the physiological properties of single neurons were characterized, one at a time, in behaving or anesthe ... Link to item Cite

Calbindin-containing non-specific thalamocortical projecting neurons in the rat.

Journal Article Brain Res · March 4, 1996 Immunoreactivity for calcium binding proteins was used to demonstrate the neurochemical profiles of non-specific thalamocortical neurons located in the ventromedial nucleus, the centrolateral nucleus, and the nucleus reuniens that project to the somatosens ... Full text Link to item Cite

Sensorimotor encoding by synchronous neural ensemble activity at multiple levels of the somatosensory system.

Journal Article Science · June 2, 1995 Neural ensemble processing of sensorimotor information during behavior was investigated by simultaneously recording up to 48 single neurons at multiple relays of the rat trigeminal somatosensory system. Cortical, thalamic, and brainstem neurons exhibited w ... Full text Link to item Cite

Development of direct GABAergic projections from the zona incerta to the somatosensory cortex of the rat.

Journal Article Neuroscience · March 1995 The postnatal development of direct thalamocortical projections from the zona incerta of the ventral thalamus to the whisker representation area of the rat primary somatosensory cortex was investigated. Cytoarchitectonic analysis based on Nissl staining, c ... Full text Link to item Cite

Beyond single unit recording: Characterizing neural information in networks of simultaneously recorded neurons

Conference SCALE IN CONSCIOUS EXPERIENCE: IS THE BRAIN TOO IMPORTANT TO BE LEFT TO SPECIALISTS TO STUDY? · January 1, 1995 Link to item Cite

Spatiotemporal structure of somatosensory responses of many-neuron ensembles in the rat ventral posterior medial nucleus of the thalamus.

Journal Article J Neurosci · June 1994 Classically, the rat ventral posterior medial (VPM) nucleus of the thalamus has been considered as a simple passive relay for single-whisker information to the primary somatosensory cortex (SI). However, recent reports have suggested that the VPM could con ... Full text Link to item Cite

Dynamic and distributed properties of many-neuron ensembles in the ventral posterior medial thalamus of awake rats.

Journal Article Proc Natl Acad Sci U S A · March 15, 1993 The traditional view that the map of the face in the ventral posterior medial thalamus (VPM) is static and highly discrete was derived largely from qualitative studies that reported only small, robust, and nonoverlapping receptive fields (RFs). Here, by us ... Full text Link to item Cite

Induction of immediate spatiotemporal changes in thalamic networks by peripheral block of ascending cutaneous information.

Journal Article Nature · February 11, 1993 Peripheral sensory deprivation induces reorganization within the somatosensory cortex of adult animals. Although most studies have focused on the somatosensory cortex, changes at subcortical levels (for example the thalamus) could also play a fundamental r ... Full text Link to item Cite

Somatotopic maps within the zona incerta relay parallel GABAergic somatosensory pathways to the neocortex, superior colliculus, and brainstem.

Journal Article Brain Res · April 10, 1992 Neurons located in the zona incerta (ZI) of the ventral thalamus project to several regions of the central nervous system, including the neocortex, superior colliculus, and brainstem. However, whether these projections are functionally segregated remains u ... Full text Link to item Cite

Neonatal whisker removal in rats stabilizes a transient projection from the auditory thalamus to the primary somatosensory cortex.

Journal Article Brain Res · December 13, 1991 A normally transient cross-modal thalamocortical projection from the magnocellular subdivision of the medial geniculate nucleus (MGm) to the primary somatosensory (SI) cortex of rats was found to remain unchanged throughout adulthood following unilateral r ... Full text Link to item Cite

Thalamic plasticity induced by early whisker removal in rats.

Journal Article Brain Res · October 11, 1991 Neurophysiological mapping was used to study the effects of early postnatal removal of mystacial whiskers on the organization of cutaneous receptive fields (RFs) within the ventral posterior thalamus (VP) of rats. This sensory deprivation induced an extens ... Full text Link to item Cite

Structural analysis of neural circuits using the theory of directed graphs.

Journal Article Comput Biomed Res · February 1991 A new approach to analysis of structural properties of biological neural circuits is proposed based on their representation in the form of abstract structures called directed graphs. To exemplify this methodology, structural properties of a biological neur ... Full text Link to item Cite

Ontogeny of corticocortical projections of the rat somatosensory cortex.

Journal Article Somatosens Mot Res · 1991 Rhodamine-coated microspheres (RCMs) were injected into the primary somatosensory cortex (SI) of rats ranging in age from postnatal (PN) day 1 to adulthood. Ipsilateral corticocortical and callosal projections within the SI were identified as early as PN d ... Full text Link to item Cite

Rhythmic bacterial susceptibility to antibiotics at a large hospital.

Journal Article J Clin Epidemiol · 1991 The in vitro susceptibility response of Staphylococcus aureus, Klebsiella pneumoniae, Escherichia coli, Proteus mirabilis and Pseudomonas aeruginosa to a set of antibiotics was investigated in a survey comprising 19,380 positive cultures over a period of 5 ... Full text Link to item Cite

A major direct GABAergic pathway from zona incerta to neocortex.

Journal Article Science · June 22, 1990 Retrograde fluorescent tracers were used to demonstrate a previously unknown but sizable direct gamma-aminobutyric acid (GABA)-containing neuronal pathway from the zona incerta to the neocortex in rats. This incertocortical pathway was found to project bil ... Full text Link to item Cite

Connection, a microcomputer program for storing and analyzing structural properties of neural circuits.

Journal Article Comput Biomed Res · February 1990 The application of a microcomputer-based system (the Connection system) designed to deal with neuroanatomical information commonly analyzed by researchers and involved in the study of structural properties of neural circuits is presented. This system can b ... Full text Link to item Cite

Structural characterization of the neural circuit responsible for control of cardiovascular functions in higher vertebrates.

Journal Article Comput Biol Med · 1990 A comparison of structural properties of a biological neural system responsible for cardiovascular function control in higher vertebrates with randomly connected networks was pursued using matrix representations of those circuits. The biological circuit wa ... Full text Link to item Cite

Using computers to survey the epidemiological, environmental and genetic factors involved in the process of bacteria resistance acquisition

Journal Article Proceedings - Annual Symposium on Computer Applications in Medical Care · December 1, 1989 The sensitivity behaviors in time of several species (S. aureus, E. coli, K. pneumoniae, and P. mirabilis in a total of 16,334 positive cultures collected at the authors' hospital from July 1981 to December 1986) to amikacin and gentamicin are shown to be ... Cite

Collagen fibril diameters in arteries of mice

Journal Article Cells Tissues Organs · January 1, 1989 Arteries of mice were studied by a silver impregnation technique, by the Picrosirius-polarization method and by transmission electron microscopy. The histochemical results obtained coincided with the electron-microscopic observations in showing the presenc ... Full text Cite

Collagen fibril diameters in arteries of mice. A comparison of manual and computer-aided morphometric analyses.

Journal Article Acta Anat (Basel) · 1989 Arteries of mice were studied by a silver impregnation technique, by the Picrosirius-polarization method and by transmission electron microscopy. The histochemical results obtained coincided with the electron-microscopic observations in showing the presenc ... Link to item Cite

Defining criteria for quantitative analysis of the neural network responsible for the cardiovascular function control by means of a microcomputer system

Journal Article Proceedings - Annual Symposium on Computer Applications in Medical Care · November 1, 1988 Software designed to deal with information from pathways connecting nuclei of the central nervous system was used to study the neural network related to the cardiovascular control in high vertebrates. The 39 most-cited nuclei in the literature and 123 link ... Cite

Time series analysis of rhythmic bacterial resistance development to antibiotics.

Journal Article Comput Biomed Res · April 1988 The sensitivity data of Staphylococcus aureus and Escherichia coli to a large set of antibiotics have undergone time series procedures of analysis in order to highlight possibly periodical behavior in time. These oscillational patterns have been characteri ... Full text Link to item Cite

Application of a microcomputer-based system in the analysis of infection data at the emergency units of a large hospital.

Journal Article Int J Biomed Comput · 1988 After three years of retrospective study in four emergency units from a large hospital (2000 beds) and analysis of 6283 positive cultures, a microcomputer database system was built to store information concerning nosocomial infections in order to help the ... Full text Link to item Cite

Developing a multi-purpose microcomputer-based system for biological signal analysis for cardiovascular protocols

Journal Article Computers in Cardiology · December 1, 1987 A description is given of the development of a general microcomputer-based system to perform biological signal processing concerning clinical and experimental protocols in cardiology. At intensive care units the software of this system enabled the clinical ... Cite

Bedside computerized system for monitoring and processing of biological signals in intensive care units

Journal Article Computers in Cardiology · December 1, 1987 A description is given of the application of a generic bedside system, developed using an IBM-PC compatible, with the aim of getting essential biological signals to perform a complete cardiovascular function analysis. Six cardiac patients with critical hea ... Cite

A mathematical model for spirometry.

Journal Article Comput Biomed Res · April 1987 A model originally designed to fit population growth data was investigated to determine whether it could fit spirometric traces as a function of time in normal and ill humans and in normal rats, obtained, respectively, by spirometer and whole-body plethysm ... Full text Link to item Cite

Mathematical model of Klebsiella pneumoniae resistance to amikacin and gentamicin.

Journal Article Braz J Med Biol Res · 1987 1. The resistance of Klebsiella pneumoniae to amikacin and gentamicin was studied by a mathematical model to predict the rate of sensitivity decrease. The results accurately matched experimental data, showing that the model is a reliable predicting tool. 2 ... Link to item Cite

[Standardization of antimicrobial procedures using computers].

Journal Article Rev Hosp Clin Fac Med Sao Paulo · 1985 Link to item Cite

Pulmonary function of rats exposed to ethanol and gasoline fumes.

Journal Article Braz J Med Biol Res · 1985 This paper describes the effects of repeated exposure to gasoline and ethanol exhaust fumes on the pulmonary mechanics of rats assessed by whole-body plethysmography. Two groups of 12 male Wistar albino rats each were tested before and after exposure to di ... Link to item Cite