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Mohamed A. F. Noor

Professor of Biology
Biology
Duke Box 90338, Biology Department, Durham, NC 27708-4129
130 Science Drive, Room 137, Duke Box 90338, Durham, NC 27708

Selected Publications


Interrogating the Roles of Mutation-Selection Balance, Heterozygote Advantage, and Linked Selection in Maintaining Recessive Lethal Variation in Natural Populations.

Journal Article Annual review of animal biosciences · February 2023 For nearly a century, evolutionary biologists have observed chromosomes that cause lethality when made homozygous persisting at surprisingly high frequencies (>25%) in natural populations of many species. The evolutionary forces responsible for the mainten ... Full text Cite

Thinking outside Earth’s box—how might heredity and evolution differ on other worlds?

Journal Article Evolution: Education and Outreach · December 1, 2022 Scholars and the public conceive of extraterrestrial life through the lens of "life as we know it" on Earth. However, assumptions based on centuries of study around heredity and evolution on Earth may not apply to life truly independent forms of life, and ... Full text Cite

Gene flow biases population genetic inference of recombination rate.

Journal Article G3 (Bethesda, Md.) · November 2022 Accurate estimates of the rate of recombination are key to understanding a host of evolutionary processes as well as the evolution of the recombination rate itself. Model-based population genetic methods that infer recombination rates from patterns of link ... Full text Cite

PseudoBase: a genomic visualization and exploration resource for the Drosophila pseudoobscura subgroup.

Journal Article Fly · December 2021 Featured Publication Drosophila pseudoobscura is a classic model system for the study of evolutionary genetics and genomics. Given this long-standing interest, many genome sequences have accumulated for D. pseudoobscura and closely related species D. persimili ... Full text Cite

Intraspecific Genetic Variation for Behavioral Isolation Loci in Drosophila.

Journal Article Genes · October 2021 Behavioral isolation is considered to be the primary mode of species isolation, and the lack of identification of individual genes for behavioral isolation has hindered our ability to address fundamental questions about the process of speciation. One of th ... Full text Cite

Inversions shape the divergence of Drosophila pseudoobscura and Drosophila persimilis on multiple timescales.

Journal Article Evolution; international journal of organic evolution · July 2021 By shaping meiotic recombination, chromosomal inversions can influence genetic exchange between hybridizing species. Despite the recognized importance of inversions in evolutionary processes such as divergence and speciation, teasing apart the effects of i ... Full text Cite

Homage to Felsenstein 1981, or why are there so few/many species?

Journal Article Evolution; international journal of organic evolution · May 2021 If there are no constraints on the process of speciation, then the number of species might be expected to match the number of available niches and this number might be indefinitely large. One possible constraint is the opportunity for allopatric divergence ... Full text Cite

Natural Selection Shapes Variation in Genome-wide Recombination Rate in Drosophila pseudoobscura.

Journal Article Current biology : CB · April 2020 While recombination is widely recognized to be a key modulator of numerous evolutionary phenomena, we have a poor understanding of how recombination rate itself varies and evolves within a species. Here, we performed a comprehensive study of recombination ... Full text Cite

Pervasive gene conversion in chromosomal inversion heterozygotes.

Journal Article Molecular ecology · March 2019 Chromosomal inversions shape recombination landscapes, and species differing by inversions may exhibit reduced gene flow in these regions of the genome. Though single crossovers within inversions are not usually recovered from inversion heterozygotes, the ... Full text Cite

Live Long and Evolve What Star Trek Can Teach Us about Evolution, Genetics, and Life on Other Worlds

Book · September 18, 2018 He explains how certain creatures depicted in the series are bisexual, not asexual, and what evolutionary advantage that difference provides. ... Cite

Are Lethal Alleles Too Abundant in Humans?

Journal Article Trends in genetics : TIG · February 2018 Across species, many individuals carry one or more recessive lethal alleles, posing an evolutionary conundrum for their persistence. Using a population genomic approach, Amorim et al. studied the abundance of lethal disease-causing mutations in humans and ... Full text Cite

Interpreting the genomic landscape of speciation: a road map for finding barriers to gene flow.

Journal Article Journal of evolutionary biology · August 2017 Speciation, the evolution of reproductive isolation among populations, is continuous, complex, and involves multiple, interacting barriers. Until it is complete, the effects of this process vary along the genome and can lead to a heterogeneous genomic land ... Full text Cite

Variation in Recombination Rate: Adaptive or Not?

Journal Article Trends in genetics : TIG · May 2017 Rates of meiotic recombination are widely variable both within and among species. However, the functional significance of this variation remains largely unknown. Is the observed within-species variation in recombination rate adaptive? Recent work has revea ... Full text Cite

Reproductive interference by male Drosophila subobscura on female D. persimilis: A laboratory experiment.

Journal Article Ecology and evolution · April 2017 While females often reject courtship attempts by heterospecific males, reproductive interference by harassment from such males can nonetheless occur, potentially reducing female fitness. Such effects may be profound following a range expansion, when males ... Full text Cite

Gene conversion and linkage: effects on genome evolution and speciation.

Journal Article Molecular ecology · January 2017 Crossing over is well known to have profound effects on patterns of genetic diversity and genome evolution. Far less direct attention has been paid to another distinct outcome of meiotic recombination: noncrossover gene conversion (NCGC). Crossing over and ... Full text Cite

The large X-effect on secondary sexual characters and the genetics of variation in sex comb tooth number in Drosophila subobscura.

Journal Article Ecology and evolution · January 2017 Genetic studies of secondary sexual traits provide insights into whether and how selection drove their divergence among populations, and these studies often focus on the fraction of variation attributable to genes on the X-chromosome. However, such studies ... Full text Cite

The (R)Evolution is here!

Journal Article Evolution; international journal of organic evolution · January 2017 Full text Cite

Transparency and reproducibility in evolutionary research.

Journal Article Evolution; international journal of organic evolution · July 2016 Full text Cite

Transparency and reproducibility in evolutionary research

Journal Article Ecology and Evolution · July 1, 2016 Full text Cite

Transparency and reproducibility in evolutionary research.

Journal Article Journal of evolutionary biology · July 2016 Full text Cite

Interrogating the Roles of Mutation-Selection Balance, Heterozygote Advantage, and Linked Selection in Maintaining Recessive Lethal Variation in Natural Populations.

Journal Article Annual review of animal biosciences · February 2023 For nearly a century, evolutionary biologists have observed chromosomes that cause lethality when made homozygous persisting at surprisingly high frequencies (>25%) in natural populations of many species. The evolutionary forces responsible for the mainten ... Full text Cite

Thinking outside Earth’s box—how might heredity and evolution differ on other worlds?

Journal Article Evolution: Education and Outreach · December 1, 2022 Scholars and the public conceive of extraterrestrial life through the lens of "life as we know it" on Earth. However, assumptions based on centuries of study around heredity and evolution on Earth may not apply to life truly independent forms of life, and ... Full text Cite

Gene flow biases population genetic inference of recombination rate.

Journal Article G3 (Bethesda, Md.) · November 2022 Accurate estimates of the rate of recombination are key to understanding a host of evolutionary processes as well as the evolution of the recombination rate itself. Model-based population genetic methods that infer recombination rates from patterns of link ... Full text Cite

PseudoBase: a genomic visualization and exploration resource for the Drosophila pseudoobscura subgroup.

Journal Article Fly · December 2021 Featured Publication Drosophila pseudoobscura is a classic model system for the study of evolutionary genetics and genomics. Given this long-standing interest, many genome sequences have accumulated for D. pseudoobscura and closely related species D. persimili ... Full text Cite

Intraspecific Genetic Variation for Behavioral Isolation Loci in Drosophila.

Journal Article Genes · October 2021 Behavioral isolation is considered to be the primary mode of species isolation, and the lack of identification of individual genes for behavioral isolation has hindered our ability to address fundamental questions about the process of speciation. One of th ... Full text Cite

Inversions shape the divergence of Drosophila pseudoobscura and Drosophila persimilis on multiple timescales.

Journal Article Evolution; international journal of organic evolution · July 2021 By shaping meiotic recombination, chromosomal inversions can influence genetic exchange between hybridizing species. Despite the recognized importance of inversions in evolutionary processes such as divergence and speciation, teasing apart the effects of i ... Full text Cite

Homage to Felsenstein 1981, or why are there so few/many species?

Journal Article Evolution; international journal of organic evolution · May 2021 If there are no constraints on the process of speciation, then the number of species might be expected to match the number of available niches and this number might be indefinitely large. One possible constraint is the opportunity for allopatric divergence ... Full text Cite

Natural Selection Shapes Variation in Genome-wide Recombination Rate in Drosophila pseudoobscura.

Journal Article Current biology : CB · April 2020 While recombination is widely recognized to be a key modulator of numerous evolutionary phenomena, we have a poor understanding of how recombination rate itself varies and evolves within a species. Here, we performed a comprehensive study of recombination ... Full text Cite

Pervasive gene conversion in chromosomal inversion heterozygotes.

Journal Article Molecular ecology · March 2019 Chromosomal inversions shape recombination landscapes, and species differing by inversions may exhibit reduced gene flow in these regions of the genome. Though single crossovers within inversions are not usually recovered from inversion heterozygotes, the ... Full text Cite

Live Long and Evolve What Star Trek Can Teach Us about Evolution, Genetics, and Life on Other Worlds

Book · September 18, 2018 He explains how certain creatures depicted in the series are bisexual, not asexual, and what evolutionary advantage that difference provides. ... Cite

Are Lethal Alleles Too Abundant in Humans?

Journal Article Trends in genetics : TIG · February 2018 Across species, many individuals carry one or more recessive lethal alleles, posing an evolutionary conundrum for their persistence. Using a population genomic approach, Amorim et al. studied the abundance of lethal disease-causing mutations in humans and ... Full text Cite

Interpreting the genomic landscape of speciation: a road map for finding barriers to gene flow.

Journal Article Journal of evolutionary biology · August 2017 Speciation, the evolution of reproductive isolation among populations, is continuous, complex, and involves multiple, interacting barriers. Until it is complete, the effects of this process vary along the genome and can lead to a heterogeneous genomic land ... Full text Cite

Variation in Recombination Rate: Adaptive or Not?

Journal Article Trends in genetics : TIG · May 2017 Rates of meiotic recombination are widely variable both within and among species. However, the functional significance of this variation remains largely unknown. Is the observed within-species variation in recombination rate adaptive? Recent work has revea ... Full text Cite

Reproductive interference by male Drosophila subobscura on female D. persimilis: A laboratory experiment.

Journal Article Ecology and evolution · April 2017 While females often reject courtship attempts by heterospecific males, reproductive interference by harassment from such males can nonetheless occur, potentially reducing female fitness. Such effects may be profound following a range expansion, when males ... Full text Cite

Gene conversion and linkage: effects on genome evolution and speciation.

Journal Article Molecular ecology · January 2017 Crossing over is well known to have profound effects on patterns of genetic diversity and genome evolution. Far less direct attention has been paid to another distinct outcome of meiotic recombination: noncrossover gene conversion (NCGC). Crossing over and ... Full text Cite

The large X-effect on secondary sexual characters and the genetics of variation in sex comb tooth number in Drosophila subobscura.

Journal Article Ecology and evolution · January 2017 Genetic studies of secondary sexual traits provide insights into whether and how selection drove their divergence among populations, and these studies often focus on the fraction of variation attributable to genes on the X-chromosome. However, such studies ... Full text Cite

The (R)Evolution is here!

Journal Article Evolution; international journal of organic evolution · January 2017 Full text Cite

Transparency and reproducibility in evolutionary research.

Journal Article Evolution; international journal of organic evolution · July 2016 Full text Cite

Transparency and reproducibility in evolutionary research

Journal Article Ecology and Evolution · July 1, 2016 Full text Cite

Transparency and reproducibility in evolutionary research.

Journal Article Journal of evolutionary biology · July 2016 Full text Cite

Mistaken Identity: Another Bias in the Use of Relative Genetic Divergence Measures for Detecting Interspecies Introgression.

Journal Article PloS one · January 2016 Measures of genetic divergence have long been used to identify evolutionary processes operating within and between species. However, recent reviews have described a bias in the use of relative divergence measures towards incorrectly identifying genomic reg ... Full text Open Access Cite

Recombining without Hotspots: A Comprehensive Evolutionary Portrait of Recombination in Two Closely Related Species of Drosophila.

Journal Article Genome biology and evolution · October 2015 Meiotic recombination rate varies across the genome within and between individuals, populations, and species in virtually all taxa studied. In almost every species, this variation takes the form of discrete recombination hotspots, determined in some mammal ... Full text Cite

Temporal Stability of Molecular Diversity Measures in Natural Populations of Drosophila pseudoobscura and Drosophila persimilis.

Journal Article Journal of Heredity · July 2015 Many molecular ecological and evolutionary studies sample wild populations at a single point in time, but that data represents genetic variation from a potentially unrepresentative snapshot in time. Variation across time in genetic parameters may occur qui ... Full text Cite

Genetics and evolution: an iOS application to supplement introductory courses in transmission and evolutionary genetics.

Journal Article G3 (Bethesda, Md.) · April 2014 Students in college courses struggle to understand many concepts fundamental to transmission and evolutionary genetics, including multilocus inheritance, recombination, Hardy-Weinberg, and genetic drift. These students consistently ask for more demonstrati ... Full text Cite

Studying recombination with high-throughput sequencing: an educational primer for use with "fine-scale heterogeneity in crossover rate in the garnet-scalloped region of the Drosophila melanogaster X chromosome".

Journal Article Genetics · June 2013 An article by Singh and colleagues in this issue of GENETICS quantifies variation in recombination rate across a small region of the Drosophila melanogaster genome, providing an opportunity for instructors of genetics to introduce or reinforce important co ... Full text Cite

The 2013 Novitski Prize: Jonathan Pritchard.

Journal Article Genetics · May 2013 Full text Cite

Hybrid Sterility

Chapter · February 27, 2013 Hybrid sterility occurs when two species mate and produce progeny that cannot attract mates, perform mating, or produce viable progeny. Not all species exhibit hybrid sterility when mated with another, but hybrid sterility is commonly detected among closel ... Full text Cite

Witnessing Evolution First-hand: A K-12 Laboratory Exercise in Genetics and Evolution Using Drosophila

Journal Article American Biology Teacher · 2013 We present a laboratory exercise that leverages student interest in genetics to observe and understand evolution by natural selection. Students begin with white-eyed fruit fly populations, to which they introduce a single advantageous variant (one male wit ... Full text Cite

Finding Selection in All the Right Places: A College Genetics Laboratory Inquiry-Based Learning Exercise

Journal Article Genetics Society of America Education Resources · 2013 This inquiry-based laboratory introduces students to evolutionary genetics using bioinformatics and biocuration. The exercise focuses on manual curation and analysis of genome sequences from closely related species. Students assess computationally-genera ... Full text Cite

How hot are drosophila hotspots? examining recombination rate variation and associations with nucleotide diversity, divergence, and maternal age in Drosophila pseudoobscura.

Journal Article PloS one · January 2013 Fine scale meiotic recombination maps have uncovered a large amount of variation in crossover rate across the genomes of many species, and such variation in mammalian and yeast genomes is concentrated to <5kb regions of highly elevated recombination rates ... Full text Cite

Witnessing phenotypic and molecular evolution in the fruit fly

Journal Article Evolution: Education and Outreach · December 2012 Full text Link to item Cite

Mentor vs. Monolith

Journal Article AMERICAN SCIENTIST · November 1, 2012 Link to item Cite

Effects of premature termination codon polymorphisms in the Drosophila pseudoobscura subclade.

Journal Article Journal of molecular evolution · October 2012 Premature termination codon (PTC) mutations can have dramatic effects--both adaptive and deleterious--on gene expression and function. Here, we examine the number and selective effects of PTC mutations within the Drosophila pseudoobscura subclade using 18 ... Full text Cite

Mapping of within-species segregation distortion in Drosophila persimilis and hybrid sterility between D. persimilis and D. pseudoobscura.

Journal Article Journal of evolutionary biology · October 2012 In contrast to the prevailing dogma in the 1990s, recent studies have suggested that an evolutionary history of segregation distortion within species may contribute to sterility in species hybrids. However, this recent work identified segregation distortio ... Full text Cite

Geographic selection in the small heat shock gene complex differentiating populations of Drosophila pseudoobscura.

Journal Article The Journal of heredity · May 2012 Environmental temperature plays a crucial role in determining a species distribution and abundance by affecting individual physiological processes, metabolic activities, and developmental rates. Many studies have identified clinal variation in phenotypes a ... Full text Cite

Genomic impacts of chromosomal inversions in parapatric Drosophila species.

Journal Article Philosophical transactions of the Royal Society of London. Series B, Biological sciences · February 2012 Chromosomal inversions impact genetic variation and facilitate speciation in part by reducing recombination in heterokaryotypes. We generated multiple whole-genome shotgun sequences of the parapatric species pair Drosophila pseudoobscura and Drosophila per ... Full text Cite

You're Hired! Now What?

Book · January 1, 2012 Cite

Recombination modulates how selection affects linked sites in Drosophila.

Journal Article PLoS biology · January 2012 One of the most influential observations in molecular evolution has been a strong association between local recombination rate and nucleotide polymorphisms across the genome. This is interpreted as evidence for ubiquitous natural selection. The alternative ... Full text Cite

Zinc finger binding motifs do not explain recombination rate variation within or between species of Drosophila.

Journal Article PloS one · January 2012 In humans and mice, the Cys(2)His(2) zinc finger protein PRDM9 binds to a DNA sequence motif enriched in hotspots of recombination, possibly modifying nucleosomes, and recruiting recombination machinery to initiate Double Strand Breaks (DSBs). However, sin ... Full text Cite

What do we need to know about speciation?

Journal Article Trends in ecology & evolution · January 2012 Speciation has been a major focus of evolutionary biology research in recent years, with many important advances. However, some of the traditional organising principles of the subject area no longer provide a satisfactory framework, such as the classificat ... Full text Cite

Recombination rate variation in closely related species.

Journal Article Heredity · December 2011 Despite their importance to successful meiosis and various evolutionary processes, meiotic recombination rates sometimes vary within species or between closely related species. For example, humans and chimpanzees share virtually no recombination hotspot lo ... Full text Cite

Genetics of hybrid male sterility among strains and species in the Drosophila pseudoobscura species group.

Journal Article Evolution; international journal of organic evolution · July 2011 Taxa in the early stages of speciation may bear intraspecific allelic variation at loci conferring barrier traits in hybrids such as hybrid sterility. Additionally, hybridization may spread alleles that confer barrier traits to other taxa. Historically, fe ... Full text Cite

Effects of inversions on within- and between-species recombination and divergence.

Journal Article Genome biology and evolution · January 2011 Chromosomal inversions disrupt recombination in heterozygotes by both reducing crossing-over within inverted regions and increasing it elsewhere in the genome. The reduction of recombination in inverted regions facilitates the maintenance of hybridizing sp ... Full text Cite

Genetic and evolutionary correlates of fine-scale recombination rate variation in Drosophila persimilis.

Journal Article Journal of molecular evolution · December 2010 Recombination is fundamental to meiosis in many species and generates variation on which natural selection can act, yet fine-scale linkage maps are cumbersome to construct. We generated a fine-scale map of recombination rates across two major chromosomes i ... Full text Cite

Genetics of incipient speciation in Drosophila mojavensis. III. Life-history divergence in allopatry and reproductive isolation.

Journal Article Evolution; international journal of organic evolution · December 2010 We carried out a three-tiered genetic analysis of egg-to-adult development time and viability in ancestral and derived populations of cactophilic Drosophila mojavensis to test the hypothesis that evolution of these life-history characters has shaped premat ... Full text Cite

Epistasis among Drosophila persimilis factors conferring hybrid male sterility with D. pseudoobscura bogotana.

Journal Article PLoS One · October 2010 The Bateson-Dobzhansky-Muller model posits that hybrid incompatibilities result from genetic changes that accumulate during population divergence. Indeed, much effort in recent years has been devoted to identifying genes associated with hybrid incompatibil ... Full text Open Access Cite

Translocation of Y-linked genes to the dot chromosome in Drosophila pseudoobscura.

Journal Article Molecular biology and evolution · July 2010 One of the most striking cases of sex chromosome reorganization in Drosophila occurred in the lineage ancestral to Drosophila pseudoobscura, where there was a translocation of Y-linked genes to an autosome. These genes went from being present only in males ... Full text Cite

The scuttle fly.

Journal Article Current biology : CB · June 2010 Full text Cite

Slip-sliding away: serial changes and homoplasy in repeat number in the Drosophila yakuba homolog of human cancer susceptibility gene BRCA2.

Journal Article PloS one · June 2010 Several recent studies have examined the function and evolution of a Drosophila homolog to the human breast cancer susceptibility gene BRCA2, named dmbrca2. We previously identified what appeared to be a recent expansion in the RAD51-binding BRC-repeat arr ... Full text Open Access Cite

The role of meiotic drive in hybrid male sterility.

Journal Article Philosophical transactions of the Royal Society of London. Series B, Biological sciences · April 2010 Meiotic drive causes the distortion of allelic segregation away from Mendelian expected ratios, often also reducing fecundity and favouring the evolution of drive suppressors. If different species evolve distinct drive-suppressor systems, then hybrid proge ... Full text Cite

Genomics: Lessons in complexity from yeast.

Journal Article Nature · April 2010 Full text Cite

Epistasis modifies the dominance of loci causing hybrid male sterility in the Drosophila pseudoobscura species group.

Journal Article Evolution · January 2010 Speciation, the evolution of reproductive isolation between populations, serves as the driving force for generating biodiversity. Postzygotic barriers to gene flow, such as F(1) hybrid sterility and inviability, play important roles in the establishment an ... Full text Cite

Slip-sliding away: Serial changes and homoplasy in repeat number in the Drosophila yakuba homolog of human cancer susceptibility gene BRCA2

Journal Article PLoS ONE · 2010 Several recent studies have examined the function and evolution of a Drosophila homolog to the human breast cancer susceptibility gene BRCA2, named dmbrca2. We previously identified what appeared to be a recent expansion in the RAD51-binding BRC-repeat arr ... Full text Cite

Islands of speciation or mirages in the desert? Examining the role of restricted recombination in maintaining species.

Journal Article Heredity · December 2009 Over the past decade, many studies documented high genetic divergence between closely related species in genomic regions experiencing restricted recombination in hybrids, such as within chromosomal rearrangements or areas adjacent to centromeres. Such regi ... Full text Cite

Molecular evolution of a Drosophila homolog of human BRCA2.

Journal Article Genetica · November 2009 The human cancer susceptibility gene, BRCA2, functions in double-strand break repair by homologous recombination, and it appears to function via interaction of a repetitive region ("BRC repeats") with RAD-51. A putatively simpler homolog, dmbrca2, was iden ... Full text Cite

Large introns in relation to alternative splicing and gene evolution: a case study of Drosophila bruno-3.

Journal Article BMC genetics · October 2009 BackgroundAlternative splicing (AS) of maturing mRNA can generate structurally and functionally distinct transcripts from the same gene. Recent bioinformatic analyses of available genome databases inferred a positive correlation between intron len ... Full text Cite

What can you do with 0.1x genome coverage? A case study based on a genome survey of the scuttle fly Megaselia scalaris (Phoridae).

Journal Article BMC genomics · August 2009 BackgroundThe declining cost of DNA sequencing is making genome sequencing a feasible option for more organisms, including many of interest to ecologists and evolutionary biologists. While obtaining high-depth, completely assembled genome sequence ... Full text Cite

The genomics of speciation in Drosophila: diversity, divergence, and introgression estimated using low-coverage genome sequencing.

Journal Article PLoS genetics · July 2009 In nature, closely related species may hybridize while still retaining their distinctive identities. Chromosomal regions that experience reduced recombination in hybrids, such as within inversions, have been hypothesized to contribute to the maintenance of ... Full text Cite

Genetics of incipient speciation in Drosophila mojavensis: II. Host plants and mating status influence cuticular hydrocarbon QTL expression and G x E interactions.

Journal Article Evolution; international journal of organic evolution · July 2009 We performed a quantitative trait locus (QTL) analysis of epicuticular hydrocarbon variation in 1650 F(2) males from crosses of Baja California and mainland Mexico populations of Drosophila mojavensis cultured on two major host cacti. Principal component ( ... Full text Cite

Sequence signatures of a recent chromosomal rearrangement in Drosophila mojavensis.

Journal Article Genetica · May 2009 The X-chromosome inversion, Xe, distinguishes Drosophila mojavensis and D. arizonae. Earlier work mapped the breakpoints of this inversion to large intervals and provided hypotheses for the locations of the breakpoints within 3000-bp intergenic regions on ... Full text Cite

Failure to replicate two mate preference QTLs across multiple strains of Drosophila pseudoobscura.

Journal Article The Journal of heredity · November 2008 Behavioral genetic mapping studies in model organisms predominantly use crosses originating from a single pair of inbred lines to determine the location of alleles that confer genetic variation in the trait of interest, and they often make sweeping general ... Full text Cite

Mutagenesis from meiotic recombination is not a primary driver of sequence divergence between Saccharomyces species.

Journal Article Molecular biology and evolution · November 2008 Local rates of recombination positively correlate with DNA sequence diversity in many species. To test whether this relationship stems from mutagenicity of meiotic recombination, studies often look for a similar association between local rates of recombina ... Full text Cite

A reversible color polyphenism in American peppered moth (Biston betularia cognataria) caterpillars.

Journal Article PloS one · September 2008 Insect body color polyphenisms enhance survival by producing crypsis in diverse backgrounds. While color polyphenisms are often indirectly induced by temperature, rearing density, or diet, insects can benefit from immediate crypsis if they evolve polypheni ... Full text Cite

Connecting recombination, nucleotide diversity and species divergence in Drosophila.

Journal Article Fly · September 2008 The association between recombination rate and nucleotide diversity provides compelling evidence for the action of natural selection across much of the Drosophila melanogaster genome. This conclusion is further supported by the lack of association between ... Full text Cite

Gene expression disruptions of organism versus organ in Drosophila species hybrids.

Journal Article PloS one · August 2008 Hybrid dysfunctions, such as sterility, may result in part from disruptions in the regulation of gene expression. Studies of hybrids within the Drosophila simulans clade have reported genes expressed above or below the expression observed in their parent s ... Full text Open Access Cite

Fine-scale mapping of recombination rate in Drosophila refines its correlation to diversity and divergence.

Journal Article Proceedings of the National Academy of Sciences of the United States of America · July 2008 Regional rates of recombination often correlate with levels of nucleotide diversity, and either selective or neutral hypotheses can explain this relationship. Regional recombination rates also correlate with nucleotide differences between human and chimpan ... Full text Cite

Polytene chromosomal maps of 11 Drosophila species: the order of genomic scaffolds inferred from genetic and physical maps.

Journal Article Genetics · July 2008 The sequencing of the 12 genomes of members of the genus Drosophila was taken as an opportunity to reevaluate the genetic and physical maps for 11 of the species, in part to aid in the mapping of assembled scaffolds. Here, we present an overview of the imp ... Full text Cite

PERMANENT GENETIC RESOURCES: Polymorphic microsatellite loci for Diachasma alloeum (Hymenoptera: Braconidae).

Journal Article Molecular ecology resources · March 2008 Here, we report the isolation of 21 novel primers for amplification of microsatellite loci in Diachasma alloeum (Hymenoptera: Braconidae). Diachasma alloeum is a larval parasitoid of the apple maggot fly (Rhagoletis pomonella), which is an economically sig ... Full text Cite

Evolution of genes and genomes on the Drosophila phylogeny.

Journal Article Nature · November 8, 2007 Comparative analysis of multiple genomes in a phylogenetic framework dramatically improves the precision and sensitivity of evolutionary inference, producing more robust results than single-genome analyses can provide. The genomes of 12 Drosophila species, ... Full text Link to item Cite

Divergence between the Drosophila pseudoobscura and D. persimilis genome sequences in relation to chromosomal inversions.

Journal Article Genetics · November 2007 As whole-genome sequence assemblies accumulate, a challenge is to determine how these can be used to address fundamental evolutionary questions, such as inferring the process of speciation. Here, we use the sequence assemblies of Drosophila pseudoobscura a ... Full text Cite

The genetics of hybrid male sterility between the allopatric species pair Drosophila persimilis and D. pseudoobscura bogotana: dominant sterility alleles in collinear autosomal regions.

Journal Article Genetics · May 2007 F(1) hybrid male sterility is thought to result from interactions between loci on the X chromosome and dominant-acting loci on the autosomes. While X-linked loci that contribute to hybrid male sterility have been precisely localized in many animal taxa, th ... Cite

Genetics of incipient speciation in Drosophila mojavensis. I. Male courtship song, mating success, and genotype x environment interactions.

Journal Article Evolution; international journal of organic evolution · May 2007 Few studies have examined genotype by environment (GxE) effects on premating reproductive isolation and associated behaviors, even though such effects may be common when speciation is driven by adaptation to different environments. In this study, mating su ... Full text Cite

Immobilized molecular beacons: a new strategy using UV-activated poly(methyl methacrylate) surfaces to provide large fluorescence sensitivities for reporting on molecular association events.

Journal Article Analytical biochemistry · April 2007 We have designed appropriately prepared solid supports consisting of poly(methyl methacrylate) (PMMA) that provide enhanced performance levels for molecular beacons (MBs) that are used for recognizing and reporting on signature DNA sequences in solution. T ... Full text Cite

Evaluation of the genomic extent of effects of fixed inversion differences on intraspecific variation and interspecific gene flow in Drosophila pseudoobscura and D. persimilis.

Journal Article Genetics · March 2007 There is increasing evidence that chromosomal inversions may facilitate the formation or persistence of new species by allowing genetic factors conferring species-specific adaptations or reproductive isolation to be inherited together and by reducing or el ... Full text Cite

Localization and characterization of X chromosome inversion breakpoints separating Drosophila mojavensis and Drosophila arizonae.

Journal Article The Journal of heredity · March 2007 Ectopic exchange between transposable elements or other repetitive sequences along a chromosome can produce chromosomal inversions. As a result, genome sequence studies typically find sequence similarity between corresponding inversion breakpoint regions. ... Full text Cite

Fine-scale crossover rate heterogeneity in Drosophila pseudoobscura.

Journal Article Journal of molecular evolution · January 2007 Broad-scale differences in crossover rate across the genome have been characterized in most genomes studied. Fine-scale differences, however, have only been examined in a few taxa, such as Arabidopsis, yeast, humans, and mice. No prior studies have directl ... Full text Cite

Genome-wide patterns of expression in Drosophila pure species and hybrid males. II. Examination of multiple-species hybridizations, platforms, and life cycle stages.

Journal Article Molecular biology and evolution · January 2007 Species often produce sterile hybrids early in their evolutionary divergence, and some evidence suggests that hybrid sterility may be associated with deviations or disruptions in gene expression. In support of this idea, many studies have shown that a high ... Full text Cite

Gene expression divergence and the origin of hybrid dysfunctions.

Journal Article Genetica · January 2007 Hybrids between closely related species are often sterile or inviable as a consequence of failed interactions between alleles from the different species. Most genetic studies have focused on localizing the alleles associated with these failed interactions, ... Full text Cite

Speciation genetics: evolving approaches.

Journal Article Nature reviews. Genetics · November 2006 Much progress has been made in the past two decades in understanding Darwin's mystery of the origins of species. Applying genomic techniques to the analysis of laboratory crosses and natural populations has helped to determine the genetic basis of barriers ... Full text Cite

Multilocus test for introgression between the cactophilic species Drosophila mojavensis and Drosophila arizonae.

Journal Article The American naturalist · November 2006 Information obtained from laboratory studies regarding the efficacy of barriers to gene flow (reproductive isolation) between species is often incomplete or misleading, so detailed genetic analyses are needed to determine whether hybridization and introgre ... Full text Cite

Evolutionary genetics: jumping into a new species.

Journal Article Curr Biol · October 2006 A new study finds a dramatic increase in transposable element numbers in three new sunflower hybrid species, and may suggest a novel role for transposable elements in speciation. ... Cite

Gene transposition as a cause of hybrid sterility in Drosophila.

Journal Article Science · September 2006 We describe reproductive isolation caused by a gene transposition. In certain Drosophila melanogaster-D. simulans hybrids, hybrid male sterility is caused by the lack of a single-copy gene essential for male fertility, JYAlpha. This gene is located on the ... Cite

New microsatellite loci for the European bushcricket, Ephippiger ephippiger (Orthoptera: Tettigoniidae)

Journal Article Molecular Ecology Notes · June 1, 2006 Ephippiger ephippiger is a model organism for studies of sexual selection and phylogeography but little is known about fine-scale population structure. Available microsatellite loci have null allele problems so we used an enrichment technique to isolate 21 ... Full text Cite

Isolation and characterization of microsatellite loci from the apple maggot fly Rhagoletis pomonella (Diptera: Tephritidae)

Journal Article Molecular Ecology Notes · March 1, 2006 We report the isolation and development of 81 novel primers for amplifying microsatellite loci in the Rhagoletis pomonella sibling species complex, and the sequencing, characterization and analysis of basic population genetic parameters for nine of these g ... Full text Cite

Simulating natural conditions in the laboratory: a re-examination of sexual isolation between sympatric and allopatric populations of Drosophila pseudoobscura and D. persimilis.

Journal Article Behavior genetics · March 2006 Simulating natural conditions in the laboratory poses one of the most significant challenges to behavioral studies. Some authors have argued that laboratory "choice" experiments reflect mate choice in nature more accurately than "no-choice" experiments. A ... Full text Cite

A recombinational portrait of the Drosophila pseudoobscura genome.

Journal Article Genet Res · February 2006 Drosophila pseudoobscura has been intensively studied by evolutionary biologists for over 70 years. The recent publication of the genome sequence not only permits studies of comparative genomics with other dipterans but also opens the door to identifying g ... Cite

No evidence for learned mating discrimination in male Drosophila pseudoobscura.

Journal Article BMC Evol Biol · 2006 BACKGROUND: Since females often pay a higher cost for heterospecific matings, mate discrimination and species recognition are driven primarily by female choice. In contrast, frequent indiscriminate matings are hypothesized to maximize male fitness. However ... Cite

Speciation in the new millennium: What's left to know?

Journal Article Israel Journal of Ecology and Evolution · 2006 Cite

Evidence for a one-allele assortative mating locus

Journal Article Science · December 2005 Theoretical models have shown that speciation with gene flow can occur readily via a "one-allele mechanism," wherein the spread of the same allele within both of two diverging species reduces their subsequent hybridization. Here, we present the first ... Cite

Evidence for a one-allele assortative mating locus.

Journal Article Science (New York, N.Y.) · December 2005 Theoretical models have shown that speciation with gene flow can occur readily via a "one-allele mechanism," where the spread of the same allele within both of two diverging species reduces their subsequent hybridization. Here we present direct genetic evi ... Full text Cite

Likelihoods from summary statistics: recent divergence between species.

Journal Article Genetics · November 2005 We describe an importance-sampling method for approximating likelihoods of population parameters based on multiple summary statistics. In this first application, we address the demographic history of closely related members of the Drosophila pseudoobscura ... Full text Open Access Cite

Patterns of evolution of genes disrupted in expression in Drosophila species hybrids.

Journal Article Genetical research · April 2005 Divergence between species in regulatory pathways may contribute to hybrid incompatibilities such as sterility. Consistent with this idea, genes involved in male fertility often evolve faster than most other genes both in amino acid sequence and in express ... Full text Cite

Comparative genome sequencing of Drosophila pseudoobscura: chromosomal, gene, and cis-element evolution.

Journal Article Genome research · January 2005 We have sequenced the genome of a second Drosophila species, Drosophila pseudoobscura, and compared this to the genome sequence of Drosophila melanogaster, a primary model organism. Throughout evolution the vast majority of Drosophila genes have remained o ... Full text Cite

The genetics of speciation by reinforcement.

Journal Article PLoS biology · December 2004 Reinforcement occurs when natural selection strengthens behavioral discrimination to prevent costly interspecies matings, such as when matings produce sterile hybrids. This evolutionary process can complete speciation, thereby providing a direct link betwe ... Full text Cite

Variation in recombination rate may bias human genetic disease mapping studies.

Journal Article Genetica · November 2004 The availability of the human genome sequence and variability information (as from the International HapMap project) will enhance our ability to map genetic disorders and choose targets for therapeutic intervention. However, several factors, such as region ... Full text Cite

A test of the chromosomal rearrangement model of speciation in Drosophila pseudoobscura.

Journal Article Evolution; international journal of organic evolution · August 2004 Recent studies suggest that chromosomal rearrangements play a significant role in speciation by preventing recombination and maintaining species persistence despite interspecies gene flow. Factors conferring adaptation or reproductive isolation are maintai ... Full text Cite

Association of misexpression with sterility in hybrids of Drosophila simulansand D. mauritiana.

Journal Article Journal of molecular evolution · August 2004 Recent studies have identified genes associated with hybrid sterility and other hybrid dysfunctions, but the consequences of introgressions of these "speciation genes" are often poorly understood. Previously, we identified a panel of genes that are underex ... Full text Cite

A microsatellite linkage map of Drosophila mojavensis.

Journal Article BMC genetics · May 2004 BackgroundDrosophila mojavensis has been a model system for genetic studies of ecological adaptation and speciation. However, despite its use for over half a century, no linkage map has been produced for this species or its close relatives.Res ... Full text Cite

Using comparative genomic data to test for fast-X evolution.

Journal Article Evolution; international journal of organic evolution · March 2004 Genes may acquire nonsynonymous substitutions more rapidly when X-linked than when autosomal, but evidence for "fast-X evolution" has been elusive. Fast-X evolution could explain the disproportionate contribution of X-linked genes to hybrid sterility and o ... Full text Cite

Molecular evolution of X-linked accessory gland proteins in Drosophila pseudoobscura.

Journal Article The Journal of heredity · March 2004 In Drosophila melanogaster and Drosophila simulans, positive Darwinian selection drives high rates of evolution of male reproductive genes, and accessory gland proteins (Acps) in particular. Here, we tested whether 13 X-linked male-specific genes, 4 Acps a ... Full text Cite

A microsatellite linkage map of Drosophila mojavensis.

Journal Article BMC genetics · 2004 Drosophila mojavensis has been a model system for genetic studies of ecological adaptation and speciation. However, despite its use for over half a century, no linkage map has been produced for this species or its close relatives. We have developed and map ... Full text Cite

Characterization of a male-predominant antisense transcript underexpressed in hybrids of Drosophila pseudoobscura and D. persimilis.

Journal Article Genetics · December 2003 Characterizing genes that are misregulated in hybrids may elucidate the genetic basis of hybrid sterility or other hybrid dysfunctions that contribute to speciation. Previously, a small segment of a male-predominant transcript that is underexpressed in adu ... Full text Cite

Genome-wide patterns of expression in Drosophila pure species and hybrid males.

Journal Article Molecular biology and evolution · July 2003 One of the most fundamental questions for understanding the origin of species is why genes that function to cause fertility in a pure-species genetic background fail to produce fertility in a hybrid genetic background. A related question is why the sex tha ... Full text Cite

The evolution of conspecific sperm precedence in Drosophila.

Journal Article Molecular ecology · May 2003 Conspecific sperm precedence takes place when females inseminated by both conspecific and heterospecific sperm preferentially produce conspecific rather than hybrid offspring. Although many studies have documented conspecific sperm precedence, most have on ... Full text Cite

Variability on the dot chromosome in the Drosophila simulans clade.

Journal Article Genetica · May 2003 A recent study suggested that recent nuclear gene introgression between Drosophila simulans and D. mauritiana may have obscured efforts to estimate the phylogeny of the species of the D. simulans clade, which includes these two species and D. sechellia. He ... Full text Cite

The Role Of Reinforcement in Speciation: Theory and Data

Journal Article Annual Review of Ecology, Evolution, and Systematics · January 1, 2003 To assess the frequency and importance of reinforcement in nature we must begin by looking for its signature in the most likely places. Theoretical studies can pinpoint conditions that favor and inhibit reinforcement, and empirical studies can identify bot ... Full text Cite

Recombination and the divergence of hybridizing species.

Journal Article Genetica · November 2002 The interplay between hybridization and recombination can have a dramatic effect on the likelihood of speciation or persistence of incompletely isolated species. Many models have suggested recombination can oppose speciation, and several recent empirical i ... Full text Cite

Strong founder effect in Drosophila pseudoobscura colonizing New Zealand from North America.

Journal Article The Journal of heredity · November 2002 The North American native species Drosophila pseudoobscura was first identified in New Zealand in the last few decades. Here, we have studied the genetic consequences of its spread across the Pacific Ocean. Using 10 microsatellites that are highly variable ... Full text Cite

Little qualitative RNA misexpression in sterile male F1 hybrids of Drosophila pseudoobscura and D. persimilis.

Journal Article BMC evolutionary biology · September 2002 BackgroundAlthough the genetics of hybrid sterility has been the subject of evolutionary studies for over sixty years, no one has shown the reason(s) why alleles that operate normally within species fail to function in another genetic background. ... Full text Cite

Microsatellite loci for great white herons and great blue herons (Aves, Ardeidae, Ardea herodias)

Journal Article Molecular Ecology Notes · June 26, 2002 We used an enrichment technique to isolate 60 microsatellite loci in Ardea herodias. We developed primers for 17 loci, screened for variation in A. herodias and attempted to amplify these loci in three closely related species (A. alba, A. cinerea and A. co ... Full text Cite

Is the biological species concept showing its age?

Journal Article Trends in Ecology and Evolution · April 1, 2002 A recent paper by Chung-I Wu in the Journal of Evolutionary Biology questions the value of the popular biological species concept (BSC) and offers an alternative 'genic' concept based on possessing 'loci of differential adaptation.' Wu suggests that recent ... Full text Cite

Population genetics of a polyploid: is there hybridization between lineages of Hyla versicolor?

Journal Article The Journal of heredity · March 2002 Several studies have demonstrated that polyploid species can form recurrently from their progenitors, but few studies have evaluated gene flow between the resultant polyploid lineages. Here we examine the possibility of hybridization between lineages of th ... Full text Cite

Comparative genetic structure between tropical Colombian and North American Drosophila pseudoobscura populations

Journal Article Biotropica · January 1, 2002 Since the discovery of Drosophila pseudoobscura in the tropical highlands of the Colombian Andes during the 1960s, this population has been studied by many evolutionary biologists because of its geographical isolation from the main North American range of ... Full text Cite

Chromosomal inversions and the reproductive isolation of species.

Journal Article Proceedings of the National Academy of Sciences of the United States of America · October 2001 Recent genetic studies have suggested that many genes contribute to differences between closely related species that prevent gene exchange, particularly hybrid male sterility and female species preferences. We have examined the genetic basis of hybrid ster ... Full text Cite

Consequences of recombination rate variation on quantitative trait locus mapping studies. Simulations based on the Drosophila melanogaster genome.

Journal Article Genetics · October 2001 We examine the effect of variation in gene density per centimorgan on quantitative trait locus (QTL) mapping studies using data from the Drosophila melanogaster genome project and documented regional rates of recombination. There is tremendous variation in ... Full text Cite

Evolutionary history of microsatellites in the obscura group of Drosophila.

Journal Article Molecular biology and evolution · April 2001 The evolutionary origins of microsatellites are not well understood. Some investigators have suggested that point mutations that expand repeat arrays beyond a threshold size trigger microsatellites to become variable. However, little empirical data has bee ... Full text Cite

Differences in (G+C) content between species: a commentary on Forsdyke's "chromosomal viewpoint" of speciation.

Journal Article Journal of theoretical biology · March 2001 Forsdyke (1999) has recently argued that differences in (G+C)%, or G+C content, may trigger new species formation. He further argues that the genic model has shortcomings that can be overcome by his "chromosomal" (hereafter, "G+C") model. We disagree on se ... Full text Cite

The genetics of reproductive isolation and the potential for gene exchange between Drosophila pseudoobscura and D. persimilis via backcross hybrid males.

Journal Article Evolution; international journal of organic evolution · March 2001 Hybrid male sterility, hybrid inviability, sexual isolation, and a hybrid male courtship dysfunction reproductively isolate Drosophila pseudoobscura and D. persimilis. Previous studies of the genetic bases of these isolating mechanisms have yielded only li ... Full text Cite

Courtship songs of Drosophila pseudoobscura and D. persimilis. II. Genetics of species differences.

Journal Article Heredity · January 2001 Although male courtship songs have been repeatedly implicated in sexual isolation between numerous Drosophila species, no genetic studies have evaluated the genetic basis of differences between species beyond using quantitative genetic analyses of hybrids ... Full text Cite

Gene flow between Drosophila pseudoobscura and D. persimilis.

Journal Article Evolution; international journal of organic evolution · December 2000 Full text Cite

A re-evaluation of 12S ribosomal RNA variability in Drosophila pseudoobscura.

Journal Article Molecular biology and evolution · June 2000 Two recent studies have presented conflicting views on variation present within the 294 base third domain of the 12S rRNA gene in the genus Drosophila, and in D. pseudoobscura in particular. One study suggested that this gene is highly invariant across the ... Full text Cite

High frequency of microsatellites in Drosophila pseudoobscura.

Journal Article Genes & genetic systems · April 2000 Using 30,000 bp of anonymous sequence data, we note that dinucleotide repeat arrays appear to be much more common in Drosophila pseudoobscura than in D. melanogaster or D. simulans. Repeat arrays bearing five or more units are situated on average once ever ... Full text Cite

Genetic variation in the spread of Drosophila subobscura from a nonequilibrium population.

Journal Article Evolution; international journal of organic evolution · April 2000 Drosophila subobscura was first identified in North America in the early 1980s, and a newer D. subobscura population in Utah appears to have been established more than 10 years later. In this study, we use nuclear microsatellite allele frequencies, mitocho ... Full text Cite

Recombination, statistical power, and genetic studies of sexual isolation in Drosophila.

Journal Article The Journal of heredity · March 2000 Genetic studies of sexual isolation in Drosophila have generally failed to fully evaluate the effects of their sample size and recombination between markers on their conclusions. In this study we evaluate recombinational distances between markers in Drosop ... Full text Cite

Microsatellite variation in populations of Drosophila pseudoobscura and Drosophila persimilis.

Journal Article Genetical research · February 2000 We have isolated, characterized and mapped 33 dinucleotide, three trinucleotide and one tetranucleotide repeat loci from the four major chromosomes of Drosophila pseudoobscura. Average inferred repeat unit length of the dinucleotide repeats is 12 repeat un ... Full text Cite

Effects of Genetic Dominance on Runaway Sexual Selection

Journal Article Adaptive Behavior · January 1, 2000 Distinguishing among theories of sexual selection requires that one develop diagnostic predictions that can be tested in living systems. Recently, genetic studies of female species preferences in Drosophila supported the predictions of a model of sexual se ... Full text Cite

Effects of genetic dominance on runaway sexual selection

Journal Article Adaptive Behavior · 2000 Distinguishing among theories of sexual selection requires that one develop diagnostic predictions that can be tested in living systems. Recently, genetic studies of female species preferences in Drosophila supported the predictions of a model of sexual se ... Cite

On the evolution of female mating preferences as pleiotropic byproducts of adaptive evolution

Journal Article Adaptive Behavior · January 1, 2000 Although evidence is mounting that female mating preferences evolve at least in part as incidental (pleiotropic) consequences of alleles favored by natural selection, it is less clear how such preferences can evolve when they are initially maladaptive, as ... Full text Cite

Reinforcement and other consequences of sympatry.

Journal Article Heredity · November 1999 The pattern of greater species mating discrimination between sympatric taxa than between allopatric taxa has been attributed to the strengthening of mate discrimination to avoid maladaptive hybridization. This process, termed reinforcement, has been highly ... Full text Cite

Courtship songs of Drosophila pseudoobscura and D. persimilis: analysis of variation.

Journal Article Animal behaviour · July 1998 Differences in Drosophila courtship song elements are thought to confer species sexual isolation because of the low levels of variation within species, the large differences often seen between closely related species, and the results of experiments using s ... Full text Cite

Diurnal activity patterns of Drosophila subobscura and D. pseudoobscura in sympatric populations

Journal Article American Midland Naturalist · January 1, 1998 The Old World species, Drosophila subobscura, has recently invaded North America and become sympatric with the native obscura-group species. This study investigates the summer diurnal activity patterns of two northwestern North American populations of Dros ... Full text Cite

Mutation and evolution of microsatellites in Drosophila melanogaster.

Journal Article Genetica · January 1998 Levels of nucleotide polymorphism in the Drosophila melanogaster genome are correlated with rates of recombination. This relationship may be due to hitchhiking of advantageous mutations (selective sweeps) or to continual removal of deleterious mutations fr ... Full text Cite

GENETICS OF SEXUAL ISOLATION AND COURTSHIP DYSFUNCTION IN MALE HYBRIDS OF DROSOPHILA PSEUDOOBSCURA AND DROSOPHILA PERSIMILIS.

Journal Article Evolution; international journal of organic evolution · June 1997 Despite the importance of sexual isolation to speciation, few studies have analyzed the genetic basis of interspecific mating discrimination, particularly using hybrid males. In this study, I investigated the genetic basis of sexual isolation using male hy ... Full text Cite

How often does sympatry affect sexual isolation in Drosophila?

Journal Article The American naturalist · June 1997 Full text Cite

Genetics of a difference in cuticular hydrocarbons between Drosophila pseudoobscura and D. persimilis.

Journal Article Genetical research · October 1996 We identify a fixed species difference in the relative concentrations of the cuticular hydrocarbons 2-methyl hexacosane and 5,9-pentacosadiene in Drosophila pseudoobscura and D. persimilis, and determine its genetic basis. In backcross males, this differen ... Full text Cite

Speciation by reinforcement: a model derived from studies of Drosophila.

Journal Article Genetics · July 1996 Reinforcement is an increase in premating reproductive isolation between taxa resulting from selection against hybrids. We present a model of reinforcement with a novel type of selection on female mating behavior. Previous models of reinforcement have focu ... Full text Cite

Absence of species discrimination in Drosophila pseudoobscura and D. persimilis males

Journal Article Animal Behaviour · January 1, 1996 Despite frequent assumptions in both the theoretical and empirical literature that males are indiscriminate in their courtship, species mating discrimination by males and females are approximately equally frequent in Drosophila. This study looked for evide ... Full text Cite

Reinforcement in speciation.

Journal Article Trends in ecology & evolution · December 1995 Full text Cite

Speciation driven by natural selection in Drosophila.

Journal Article Nature · June 1995 Reinforcement is the process by which natural selection strengthens sexual isolation between incipient species, reducing the frequency of maladaptive hybridization and hence completing reproductive isolation. Although this model of speciation was once wide ... Full text Cite

Long-term changes in obscura group Drosophila species composition at Mather, California

Journal Article Pan-Pacific Entomologist · January 1, 1995 Cite