Scholars@Duke
Peter Allen

Peter Allen

David C. Sabiston, Jr. Distinguished Professor of Surgery
Surgical Oncology

Selected Publications

Simple versus radical cholecystectomy and survival for pathologic stage T1B gallbladder cancer.

Journal Article HPB (Oxford) · April 2024 BACKGROUND: Radical cholecystectomy is recommended for T1B and greater gallbladder cancer, however, there are conflicting reports on the utility of extended resection for T1B disease. Herein, we characterize outcomes following simple and radical cholecyste ... Full text Link to item Cite

Initial Report: Personalized Circulating Tumor DNA and Survival in Patients with Resectable Pancreatic Cancer.

Journal Article Ann Surg Oncol · March 2024 ABSTRACT: BACKGROUND: Pancreatic adenocarcinoma (PDAC) is highly lethal with up to 80% of resected patients experiencing disease recurrence within 2 years (Watanabe, Nakamura, Kimura et al in Int J Mol Sci 23(19):11521, 2022). Cross-sectional imaging and ... Full text Link to item Cite

Development, Deployment, and Implementation of a Machine Learning Surgical Case Length Prediction Model and Prospective Evaluation.

Journal Article Ann Surg · December 1, 2023 OBJECTIVE: To implement a machine learning model using only the restricted data available at case creation time to predict surgical case length for multiple services at different locations. BACKGROUND: The operating room is one of the most expensive resour ... Full text Open Access Link to item Cite

Tumor size and survival in intrahepatic cholangiocarcinoma treated with surgical resection or ablation.

Journal Article J Surg Oncol · December 2023 OBJECTIVES: We performed a retrospective analysis within a national cancer registry on outcomes following resection or ablation for intrahepatic cholangiocarcinoma (iCCA). METHODS: The National Cancer Database was queried for patients with clinical stage I ... Full text Link to item Cite

The global state of play: A study of the demographic characteristics of disability golfers.

Journal Article PM R · October 2023 BACKGROUND: Golf is a moderate-intensity physical activity that provides positive physical and mental health benefits. However, the inclusiveness of the sport for individuals with disabilities globally is unknown. OBJECTIVE: To characterize the demographic ... Full text Link to item Cite

Comparing Survival After Resection, Ablation, and Radiation in Small Intrahepatic Cholangiocarcinoma.

Journal Article Ann Surg Oncol · October 2023 BACKGROUND: Hepatectomy is the cornerstone of curative-intent treatment for intrahepatic cholangiocarcinoma (ICC). However, in patients unable to be resected, data comparing efficacy of alternatives including thermal ablation and radiation therapy (RT) rem ... Full text Open Access Link to item Cite

Robotic Distal Pancreatectomy: A Novel Standard of Care? Benchmark Values for Surgical Outcomes From 16 International Expert Centers.

Journal Article Ann Surg · August 1, 2023 BACKGROUND AND OBJECTIVE: Robotic distal pancreatectomy (DP) is an emerging attractive approach, but its role compared with laparoscopic or open surgery remains unclear. Benchmark values are novel and objective tools for such comparisons. The aim of this s ... Full text Link to item Cite

Trends in Receipt of Adjuvant Chemotherapy and its Impact on Survival in Resected Biliary Tract Cancers.

Journal Article Ann Surg Oncol · August 2023 BACKGROUND: Resection remains the cornerstone of curative-intent treatment for biliary tract cancers (BTCs). However, recent randomized data also support a role for adjuvant chemotherapy (AC). This study aimed to characterize trends in the use of AC and su ... Full text Link to item Cite

Hepatic artery infusion for unresectable colorectal cancer liver metastases: Palliation and conversion.

Journal Article Surgery · August 2023 Patients with unresectable colorectal liver metastases are commonly treated with systemic chemotherapy to convert their disease to an operable state. Unfortunately, many patients remain unresectable after first-line chemotherapy and resort to second- and t ... Full text Link to item Cite

Revisiting the intrinsic mycobiome in pancreatic cancer.

Journal Article Nature · August 2023 A growing body of literature suggests that alterations in the human microbiome are causative of disease initiation and progression. Aykut et al. present data supporting the argument that alterations in the gut fungal microbiome (the “mycobiome”), along wit ... Full text Link to item Cite

Performance of the 7 th and 8 th Editions of the American Joint Committee on Cancer Staging System in Patients with Intraductal Papillary Mucinous Neoplasm-Associated PDAC : A Multi-institutional Analysis.

Journal Article Ann Surg · April 1, 2023 OBJECTIVE: To validate the 7 th and 8 th editions of the AJCC staging system for patients with invasive carcinomas arising in association with IPMN (IPMN-associated PDAC). BACKGROUND DATA: Although several studies have validated AJCC systems in patients wi ... Full text Link to item Cite

Digital spatial profiling of intraductal papillary mucinous neoplasms: Toward a molecular framework for risk stratification.

Journal Article Sci Adv · March 15, 2023 The histopathologic heterogeneity of intraductal papillary mucinous neoplasms (IPMN) complicates the prediction of pancreatic ductal adenocarcinoma (PDAC) risk. Intratumoral regions of pancreaticobiliary (PB), intestinal (INT), and gastric foveolar (GF) ep ... Full text Link to item Cite

Advances in the treatment of intrahepatic cholangiocarcinoma: An overview of the current and future therapeutic landscape for clinicians.

Journal Article CA Cancer J Clin · March 2023 Intrahepatic cholangiocarcinoma (ICC) is the second most common primary liver tumor and remains a fatal malignancy in the majority of patients. Approximately 20%-30% of patients are eligible for resection, which is considered the only potentially curative ... Full text Link to item Cite

Heterogeneity of Glycan Biomarker Clusters as an Indicator of Recurrence in Pancreatic Cancer.

Journal Article bioRxiv · January 6, 2023 Outcomes following tumor resection vary dramatically among patients with pancreatic cancer. A challenge in defining predictive biomarkers is to discern within the complex tumor tissue the specific subpopulations and relationships that drive recurrence. Mul ... Full text Link to item Cite

Heterogeneity of glycan biomarker clusters as an indicator of recurrence in pancreatic cancer.

Journal Article Frontiers in oncology · January 2023 IntroductionOutcomes following tumor resection vary dramatically among patients with pancreatic ductal adenocarcinoma (PDAC). A challenge in defining predictive biomarkers is to discern within the complex tumor tissue the specific subpopulations a ... Full text Open Access Cite

Functional reprogramming of peripheral blood monocytes by soluble mediators in patients with pancreatic cancer and intraductal papillary mucinous neoplasms.

Journal Article Front Immunol · 2023 BACKGROUND: Monocytes and monocyte-derived tumor infiltrating cells have been implicated in the immunosuppression and immune evasion associated with pancreatic adenocarcinoma (PDAC). Yet, precisely how monocytes in the periphery and tumor microenvironment ... Full text Link to item Cite

Evolution in Management of Upfront Treatment For Desmoid Tumors

Conference ANNALS OF SURGICAL ONCOLOGY · 2023 Cite

Considerations and barriers to starting a new HAI pump program: an international survey of the HAI Consortium Research Network.

Journal Article HPB (Oxford) · December 2022 BACKGROUND: Widespread implementation of HAI pump chemotherapy has been limited by logistic and feasibility concerns. Recent studies demonstrating excellent outcomes have fueled renewed enthusiasm and multiple new programs have emerged. This survey aims to ... Full text Link to item Cite

Hepatic Artery Infusion Pumps: A Surgical Toolkit for Intraoperative Decision-Making and Management of Hepatic Artery Infusion-Specific Complications.

Journal Article Ann Surg · December 1, 2022 BACKGROUND: Hepatic artery infusion (HAI) is a liver-directed therapy that delivers high-dose chemotherapy to the liver through the hepatic arterial system for colorectal liver metastases and intrahepatic cholangiocarcinoma. Utilization of HAI is rapidly e ... Full text Link to item Cite

Multidimensional Immunophenotyping of Intraductal Papillary Mucinous Neoplasms Reveals Novel T Cell and Macrophage Signature.

Conference Ann Surg Oncol · November 2022 BACKGROUND: Intraductal papillary mucinous neoplasms (IPMN) are the only radiographically identifiable precursor to pancreatic adenocarcinoma, yet little is known about how these lesions progress to cancer. Inflammation has been associated with dysplastic ... Full text Link to item Cite

Fifty years of pancreas cancer care.

Journal Article J Surg Oncol · October 2022 Resulting from 50 years of innovation, operations for pancreatic neoplasms can now be performed safely, albeit with significant but manageable morbidity. Molecular diagnosis has allowed for the identification of multiple distinct histopathologies with vari ... Full text Link to item Cite

Recurrence After Resection of Pancreatic Cancer: Can Radiomics Predict Patients at Greatest Risk of Liver Metastasis?

Journal Article Annals of Surgical Oncology · August 1, 2022 Background: Liver metastasis (LM) after pancreatic ductal adenocarcinoma (PDAC) resection is common but difficult to predict and has grave prognosis. We combined preoperative clinicopathological variables and quantitative analysis of computed tomography (C ... Full text Cite

Multiinstitutional Validation Study of Cyst Fluid Protein Biomarkers in Patients With Cystic Lesions of the Pancreas.

Journal Article Ann Surg · August 1, 2022 OBJECTIVE: Prospective evaluation of 2 clinical-molecular models in patients with unknown pathology who underwent endoscopic ultrasound with fine-needle aspiration (EUS-FNA) for a cystic lesion of the pancreas. SUMMARY OF BACKGROUND DATA: Preoperative pred ... Full text Link to item Cite

Surgical resection is associated with improved long-term survival of patients with resectable pancreatic head cancer compared to multiagent chemotherapy.

Journal Article HPB (Oxford) · July 2022 BACKGROUND: Standard of care for resectable pancreatic cancer is a combination of surgical resection (SR) and multiagent chemotherapy (MCT). We aim to determine whether SR or MCT is associated with superior survival for patients receiving only single-modal ... Full text Link to item Cite

Drain use in pancreatic surgery: Results from an international survey among experts in the field.

Journal Article Surgery · July 2022 BACKGROUND: Drain use in pancreatic surgery remains controversial. This survey sought to evaluate habits, experiences, and opinions of experts in the field on the use of drains to provide interesting insights for pancreatic surgeons worldwide. METHODS: An ... Full text Link to item Cite

Change in Neutrophil-to-Lymphocyte Ratio During Neoadjuvant Treatment Does Not Predict Pathological Response and Survival in Resectable Pancreatic Ductal Adenocarcinoma.

Journal Article Am Surg · June 2022 BACKGROUND: Neutrophil-to-lymphocyte ratio (NLR) has been reported as prognostic in pancreatic ductal adenocarcinoma (PDAC). Data about NLR changes during neoadjuvant therapy (NAT) and its relationship with pathological tumor response and survival are lack ... Full text Link to item Cite

Robotic distal pancreatectomy, a novel standard of care? First benchmark values for surgical outcomes from 14 international expert centers

Conference British Journal of Surgery · May 31, 2022 AbstractObjectiveRobotic distal pancreatectomy (DP) is emerging as the preferred treatment for body and tail tumors of the pancreas. T ... Full text Cite

Combined Primary Resection with Hepatic Artery Infusion Pump Implantation Is Safe for Unresectable Colorectal Liver Metastases.

Journal Article J Gastrointest Surg · April 2022 BACKGROUND: Colorectal liver metastases (CRLM) are the most common cause of disease-specific mortality in patients with colorectal cancer. Hepatic artery infusion (HAI) combined with systemic chemotherapy improves survival for these patients. The safety of ... Full text Link to item Cite

Quality of Life Associated with Open vs Minimally Invasive Pancreaticoduodenectomy: A Prospective Pilot Study.

Journal Article J Am Coll Surg · April 1, 2022 BACKGROUND: This prospective study was designed to compare quality of life (QoL) among patients who underwent open (O-PD) vs minimally invasive pancreaticoduodenectomy (MI-PD), using a combination of validated qualitative and quantitative methodologies. ST ... Full text Link to item Cite

Induction FOLFIRINOX for patients with locally unresectable pancreatic ductal adenocarcinoma.

Journal Article Journal of surgical oncology · March 2022 ObjectivesPatients with locally advanced pancreatic adenocarcinoma (PDAC) receive induction chemotherapy with or without radiation, with the goal of R0 resection and improving survival. Herein, we evaluate the outcomes of patients who presented wi ... Full text Cite

Perioperative and oncologic outcomes of hepatic artery infusion pump therapy at an expanding HAI program.

Conference Journal of Clinical Oncology · February 1, 2022 120 Background: Hepatic artery infusion (HAI) is a liver directed therapy to treat unresectable or resected colorectal liver metastases (CRLM) and unresectable intrahepatic cholangiocarcinoma (ICC). Historically, HAI has only bee ... Full text Cite

Multi-institutional Development and External Validation of a Nomogram to Predict Recurrence After Curative Resection of Pancreatic Neuroendocrine Tumors.

Journal Article Ann Surg · December 1, 2021 OBJECTIVE: To develop a nomogram estimating the probability of recurrence free at 5 years after resection for localized grade 1 (G1)/ grade 2 (G2) pancreatic neuroendocrine tumors (PanNETs). BACKGROUND: Among patients undergoing resection of PanNETs, appro ... Full text Link to item Cite

Empiric nasogastric decompression after pancreaticoduodenectomy is not necessary.

Journal Article HPB (Oxford) · December 2021 BACKGROUND: The aim of the present study was to evaluate the impact of routine NGT decompression after PD on postoperative outcomes in the era of an enhanced recovery after surgery (ERAS) protocol. MATERIALS AND METHODS: A retrospective review of all patie ... Full text Link to item Cite

Intraductal Papillary Mucinous Neoplasms: Have IAP Consensus Guidelines Changed our Approach?: Results from a Multi-institutional Study.

Journal Article Ann Surg · December 1, 2021 OBJECTIVE: To evaluate the influence of consensus guidelines on the management of intraductal papillary mucinous neoplasms (IPMN) and the subsequent changes in pathologic outcomes. BACKGROUND: Over time, multiple guidelines have been developed to identify ... Full text Link to item Cite

Genetic Determinants of Outcome in Intrahepatic Cholangiocarcinoma.

Journal Article Hepatology · September 2021 BACKGROUND AND AIM: Genetic alterations in intrahepatic cholangiocarcinoma (iCCA) are increasingly well characterized, but their impact on outcome and prognosis remains unknown. APPROACH AND RESULTS: This bi-institutional study of patients with confirmed i ... Full text Link to item Cite

Impact of Primary Tumor Laterality on Adjuvant Hepatic Artery Infusion Pump Chemotherapy in Resected Colon Cancer Liver Metastases: Analysis of 487 Patients.

Journal Article Annals of surgical oncology · July 2021 BackgroundHepatic artery infusion (HAI) chemotherapy is associated with overall survival (OS) in patients with resected colon cancer liver metastases (CLM). The prognostic impact of primary tumor location in CLM following hepatic resection in pati ... Full text Cite

In brief

Journal Article Current Problems in Surgery · June 1, 2021 Full text Cite

Long-term Outcomes After Surgical Resection of Pancreatic Metastases from Renal Clear-Cell Carcinoma.

Journal Article Ann Surg Oncol · June 2021 BACKGROUND: Pancreatic metastases (PM) from renal cell carcinoma (RCC) are uncommon. We herein describe the long-term outcomes associated with pancreatectomy at two academic institutions, with a specific focus on 10-year survival. METHODS: This investigati ... Full text Link to item Cite

Quantitative Computed Tomography Image Analysis to Predict Pancreatic Neuroendocrine Tumor Grade.

Journal Article JCO Clin Cancer Inform · June 2021 PURPOSE: The therapeutic management of pancreatic neuroendocrine tumors (PanNETs) is based on pathological tumor grade assessment. A noninvasive imaging method to grade tumors would facilitate treatment selection. This study evaluated the ability of quanti ... Full text Link to item Cite

Portal vein resection during pancreaticoduodenectomy for pancreatic neuroendocrine tumors. An international multicenter comparative study.

Journal Article Surgery · May 2021 BACKGROUND: The role of portal vein resection for pancreatic cancer is well established but not for pancreatic neuroendocrine neoplasms. Evidence from studies providing information on long-term outcome after venous resection in pancreatic neuroendocrine ne ... Full text Link to item Cite

Early liver metastases after "failure" of adjuvant chemotherapy for stage III colorectal cancer: is there a role for additional adjuvant therapy?

Journal Article HPB (Oxford) · April 2021 BACKGROUND: The utility of adjuvant chemotherapy after resection of colorectal liver metastasis (CLM) in patients with rapid recurrence after adjuvant chemotherapy for their primary tumor is unclear. The aim of this study was to evaluate the oncologic bene ... Full text Link to item Cite

Preoperative CT predictors of survival in patients with pancreatic ductal adenocarcinoma undergoing curative intent surgery.

Journal Article Abdom Radiol (NY) · April 2021 PURPOSE: To evaluate the associations between computed tomography (CT) imaging features extracted from the structured American Pancreatic Association (APA)/Society of Abdominal Radiology (SAR) template and overall survival in patients with resected pancrea ... Full text Link to item Cite

Meeting Report: Translational Advances in Cancer Prevention Agent Development Meeting.

Journal Article J Cancer Prev · March 30, 2021 The Division of Cancer Prevention of the National Cancer Institute (NCI) and the Office of Disease Prevention of the National Institutes of Health co-sponsored the Translational Advances in Cancer Prevention Agent Development Meeting on August 27 to 28, 20 ... Full text Link to item Cite

In brief

Journal Article Current Problems in Surgery · February 1, 2021 Full text Cite

Surgical management of biliary malignancy.

Journal Article Curr Probl Surg · February 2021 Full text Link to item Cite

Validation of the 8th Edition American Joint Commission on Cancer (AJCC) Gallbladder Cancer Staging System: Prognostic Discrimination and Identification of Key Predictive Factors.

Journal Article Cancers (Basel) · February 1, 2021 The scope of our study was to compare the predictive ability of American Joint Committee on Cancer (AJCC) 7th and 8th edition in gallbladder carcinoma (GBC) patients, investigate the effect of AJCC 8th nodal status on the survival, and identify risk factor ... Full text Link to item Cite

Platinum-Based Treatment for Well- and Poorly Differentiated Pancreatic Neuroendocrine Neoplasms.

Journal Article Pancreas · February 1, 2021 OBJECTIVES: Pancreatic neuroendocrine neoplasms include well-differentiated tumors (PanNETs) and poorly differentiated carcinomas (PanNECs). Previous reports suggested a role for platinum-based therapy largely in PanNEC. We sought to investigate the role o ... Full text Link to item Cite

Detailed Analysis of Margin Positivity and the Site of Local Recurrence After Pancreaticoduodenectomy.

Journal Article Ann Surg Oncol · January 2021 BACKGROUND: The association between a positive surgical margin and local recurrence after resection of pancreatic adenocarcinoma (PDAC) has been reported. Assessment of the location of the a positive margin and the specific site of local recurrence has not ... Full text Link to item Cite

Hepatocellular carcinoma in patients with no identifiable risk factors.

Journal Article HPB (Oxford) · January 2021 BACKGROUND: A subset of patients have no risk factors for the development of hepatocellular carcinoma (HCC). We evaluated differences in clinical variables between patients with and without risk factors who underwent surgical resection. METHODS: A prospect ... Full text Link to item Cite

Detection of Chemotherapy-resistant Pancreatic Cancer Using a Glycan Biomarker, sTRA.

Journal Article Clin Cancer Res · January 1, 2021 PURPOSE: A subset of pancreatic ductal adenocarcinomas (PDACs) is highly resistant to systemic chemotherapy, but no markers are available in clinical settings to identify this subset. We hypothesized that a glycan biomarker for PDACs called sialylated tumo ... Full text Link to item Cite

Invasive central venous monitoring during hepatic resection: unnecessary for most patients.

Journal Article HPB : the official journal of the International Hepato Pancreato Biliary Association · December 2020 BackgroundLow central venous pressure (LCVP) anesthesia reduces blood loss during hepatic resection and historically has required a central venous catheter (CVC) for intra-operative monitoring. The aim of this study was to assess the effect of an ... Full text Cite

Implementation of a Hepatic Artery Infusion Program: Initial Patient Selection and Perioperative Outcomes of Concurrent Hepatic Artery Infusion and Systemic Chemotherapy for Colorectal Liver Metastases.

Journal Article Ann Surg Oncol · December 2020 BACKGROUND: Hepatic artery infusion (HAI) combined with systemic chemotherapy is a treatment strategy for patients with unresectable liver-only or liver-dominant colorectal liver metastases (CRLM). Although HAI has previously been performed in only a few c ... Full text Link to item Cite

Is minimally invasive surgery of lesions in the right superior segments of the liver justified? A multi-institutional study of 245 patients.

Journal Article J Surg Oncol · December 2020 BACKGROUND: Controversy exists regarding the safety and feasibility of minimally invasive resection for lesions in segments 7 or 8. We compare outcomes of minimally invasive surgery (MIS) and Open parenchymal sparing liver resections at two high-volume cen ... Full text Link to item Cite

Short-Term Risk of Performing Concurrent Procedures with Hepatic Artery Infusion Pump Placement.

Journal Article Ann Surg Oncol · December 2020 BACKGROUND: Hepatic artery infusion pump (HAIP) chemotherapy is an advanced cancer therapy for primary and secondary hepatic malignancies. The risk of concurrent hepatic and/or colorectal operations with HAIP placement is unknown. Our objective was to char ... Full text Link to item Cite

Abstract PO-002: Detection of chemotherapy-resistant pancreatic cancer using a glycan Biomarker

Conference Cancer Research · November 15, 2020 AbstractA subset of pancreatic ductal adenocarcinomas (PDACs) is highly resistant to systemic chemotherapy, but no markers are available in clinical settings to identify this subset. In this study, we evalua ... Full text Cite

Alterations in driver genes are predictive of survival in patients with resected pancreatic ductal adenocarcinoma.

Journal Article Cancer · September 1, 2020 BACKGROUND: KRAS, TP53, CDKN2A, and SMAD4 are established driver genes in pancreatic ductal adenocarcinoma (PDAC). This study was aimed at determining whether the mutational status of driver genes and those involved in DNA repair pathways are associated wi ... Full text Link to item Cite

Adjuvant Hepatic Artery Infusion Chemotherapy is Associated With Improved Survival Regardless of KRAS Mutation Status in Patients With Resected Colorectal Liver Metastases: A Retrospective Analysis of 674 Patients.

Journal Article Ann Surg · August 2020 OBJECTIVE: To investigate the impact of adjuvant hepatic artery infusion (HAI) in relation to KRAS mutational status in patients with resected colorectal cancer liver metastases (CRLM). BACKGROUND: Patients with KRAS-mutated CRLM have worse outcomes after ... Full text Link to item Cite

Histopathological growth patterns and positive margins after resection of colorectal liver metastases.

Journal Article HPB (Oxford) · June 2020 BACKGROUND: Histopathological growth patterns (HGPs) of colorectal liver metastases (CRLM) may be an expression of biological tumour behaviour impacting the risk of positive resection margins. The current study aimed to investigate whether the non-desmopla ... Full text Link to item Cite

Lending a hand for laparoscopic distal pancreatectomy: the optimal approach?

Journal Article HPB (Oxford) · May 2020 BACKGROUND: Both minimally invasive surgery (MIS) and open approaches for distal pancreatectomy are acceptable. MIS options include total laparoscopic/robotic (TLR) and hand-assist laparoscopy (HAL). When considering safety profile and specimen quality, th ... Full text Link to item Cite

Multimodal radiomics and cyst fluid inflammatory markers model to predict preoperative risk in intraductal papillary mucinous neoplasms

Journal Article Journal of Medical Imaging · May 1, 2020 Purpose: Our paper contributes to the burgeoning field of surgical data science. Specifically, multimodal integration of relevant patient data is used to determine who should undergo a complex pancreatic resection. Intraductal papillary mucinous neoplasms ... Full text Cite

CD226 Expression is Associated with Increased Survival in Pancreatic Cancer

Conference ANNALS OF SURGICAL ONCOLOGY · February 1, 2020 Link to item Cite

Radiomic feature reproducibility in contrast-enhanced CT of the pancreas is affected by variabilities in scan parameters and manual segmentation.

Journal Article Eur Radiol · January 2020 OBJECTIVES: This study aims to measure the reproducibility of radiomic features in pancreatic parenchyma and ductal adenocarcinomas (PDAC) in patients who underwent consecutive contrast-enhanced computed tomography (CECT) scans. METHODS: In this IRB-approv ... Full text Link to item Cite

Prediction of Recurrence Patterns from Hepatic Parenchymal Disease After Resection of Colorectal Liver Metastases.

Journal Article Ann Surg Oncol · January 2020 BACKGROUND: Obesity and metabolic syndrome are associated with inflammatory hepatic parenchymal disease (HPD) and increased risk for recurrence after resection of colorectal liver metastases (CRLM). The independent impact of HPD on recurrence patterns has ... Full text Link to item Cite

Assessment of Hepatic Arterial Infusion of Floxuridine in Combination With Systemic Gemcitabine and Oxaliplatin in Patients With Unresectable Intrahepatic Cholangiocarcinoma: A Phase 2 Clinical Trial.

Journal Article JAMA Oncol · January 1, 2020 IMPORTANCE: Unresectable intrahepatic cholangiocarcinoma (IHC) carries a poor prognosis, with a median overall survival (OS) of 11 months. Hepatic arterial infusion (HAI) of high-dose chemotherapy may have potential benefit in these patients. OBJECTIVE: To ... Full text Link to item Cite

Is Hepatectomy Justified for BRAF Mutant Colorectal Liver Metastases?: A Multi-institutional Analysis of 1497 Patients.

Journal Article Ann Surg · January 2020 OBJECTIVE: To analyze clinical outcomes and prognostic variables of patients undergoing hepatic resection for BRAF mutant (BRAF-mut) colorectal liver metastases (CRLM). BACKGROUND: Outcomes following hepatectomy for BRAF-mut CRLM have not been well studied ... Full text Link to item Cite

ID1 Mediates Escape from TGFβ Tumor Suppression in Pancreatic Cancer.

Journal Article Cancer Discov · January 2020 TGFβ is an important tumor suppressor in pancreatic ductal adenocarcinoma (PDA), yet inactivation of TGFβ pathway components occurs in only half of PDA cases. TGFβ cooperates with oncogenic RAS signaling to trigger epithelial-to-mesenchymal transition (EMT ... Full text Link to item Cite

A combined radiomics and cyst fluid inflammatory markers model to predict preoperative risk in pancreatic cystic lesions

Conference Proceedings of SPIE - The International Society for Optical Engineering · January 1, 2020 This paper contributes to the burgeoning field of surgical data science. Specifically, multi-modal integration of relevant patient data is used to determine who should undergo a complex pancreatic resection. Intraductal papillary mucinous neoplasms (IPMNs) ... Full text Cite

Evolution of surgical management of gallbladder carcinoma and impact on outcome: results from two decades at a single-institution.

Journal Article HPB (Oxford) · November 2019 BACKGROUND: The surgical approach to gallbladder cancer (GBCA) has evolved in recent years, but the impact on outcomes is unknown. This study describes differences in presentation, surgery, chemotherapy strategy, and survival for patients with GBCA over tw ... Full text Link to item Cite

CT radiomics associations with genotype and stromal content in pancreatic ductal adenocarcinoma.

Journal Article Abdom Radiol (NY) · September 2019 PURPOSE: The aim of this study was to investigate the relationship between CT imaging phenotypes and genetic and biological characteristics in pancreatic ductal adenocarcinoma (PDAC). METHODS: In this retrospective study, consecutive patients between April ... Full text Link to item Cite

Cross Validation of the Monoclonal Antibody Das-1 in Identification of High-Risk Mucinous Pancreatic Cystic Lesions.

Journal Article Gastroenterology · September 2019 BACKGROUND & AIMS: Although pancreatic cystic lesions (PCLs) are frequently and incidentally detected, it is a challenge to determine their risk of malignancy. In immunohistochemical and enzyme-linked immunosorbent assay (ELISA) analyses of tissue and cyst ... Full text Link to item Cite

Outcome of Pancreatic Cancer Surveillance Among High-Risk Individuals Tested for Germline Mutations in BRCA1 and BRCA2.

Journal Article Cancer Prev Res (Phila) · September 2019 Germline mutations in BRCA1/2 are risk factors for pancreatic ductal adenocarcinoma (PDAC). The aim of this study was to evaluate whether results of surveillance for PDAC in high risk individuals (HRI) differ between those with and without a pathogenic BRC ... Full text Link to item Cite

Pilot study of rapid MR pancreas screening for patients with BRCA mutation.

Journal Article Eur Radiol · August 2019 PURPOSE: To develop and optimize a rapid magnetic resonance imaging (MRI) screening protocol for pancreatic cancer to be performed in conjunction with breast MRI screening in breast cancer susceptibility gene (BRCA)-positive individuals. METHODS: An IRB-ap ... Full text Link to item Cite

Benchmarks in Pancreatic Surgery: A Novel Tool for Unbiased Outcome Comparisons.

Journal Article Ann Surg · August 2019 OBJECTIVE: To use the concept of benchmarking to establish robust and standardized outcome references after pancreatico-duodenectomy (PD). BACKGROUND: Best achievable results after PD are unknown. Consequently, outcome comparisons among different cohorts, ... Full text Link to item Cite

A multimodality test to guide the management of patients with a pancreatic cyst.

Journal Article Sci Transl Med · July 17, 2019 Pancreatic cysts are common and often pose a management dilemma, because some cysts are precancerous, whereas others have little risk of developing into invasive cancers. We used supervised machine learning techniques to develop a comprehensive test, CompC ... Full text Link to item Cite

Neutrophil-to-Lymphocyte Ratio as a Predictor of Invasive Carcinoma in Patients With Intraductal Papillary Mucinous Neoplasms of the Pancreas.

Journal Article Pancreas · July 2019 OBJECTIVES: Preoperative determination of the grade of dysplasia in intraductal papillary mucinous neoplasms (IPMNs) is necessary for optimal management. Previous data have suggested that serum neutrophil-to-lymphocyte ratio (NLR) can predict invasive dise ... Full text Link to item Cite

Peripheral Circulating Tumor DNA Detection Predicts Poor Outcomes After Liver Resection for Metastatic Colorectal Cancer.

Journal Article Ann Surg Oncol · June 2019 BACKGROUND: Liver resection can be curative for well-selected metastatic colorectal cancer (CRC) patients. Circulating tumor DNA (ctDNA) has shown promise as a biomarker for tumor dynamics and recurrence following CRC resection. This prospective pilot stud ... Full text Link to item Cite

The diagnosis and management of intraductal papillary mucinous neoplasms of the pancreas: has progress been made?

Journal Article Updates Surg · June 2019 Intraductal papillary mucinous neoplasms (IPMN) of the pancreas are premalignant mucin-producing epithelial tumors that arise from the pancreatic ductal system. These cystic tumors represent 15-30% of cystic lesions of the pancreas [Basturk et al. in Am J ... Full text Link to item Cite

Limited role of Chromogranin A as clinical biomarker for pancreatic neuroendocrine tumors.

Journal Article HPB (Oxford) · May 2019 BACKGROUND: Serum Chromogranin A (CgA) is widely used as a biomarker for pancreatic neuroendocrine tumors (PanNETs). The aim of this study was to investigate the value of CgA as a diagnostic and prognostic marker for well-differentiated PanNETs. METHODS: P ... Full text Link to item Cite

Intraductal Oncocytic Papillary Neoplasms: Clinical-Pathologic Characterization of 24 Cases, With An Emphasis on Associated Invasive Carcinomas.

Journal Article Am J Surg Pathol · May 2019 BACKGROUND: Intraductal oncocytic papillary neoplasm (IOPN) of the pancreas is a rare tumor. Recent molecular data indicate that it is distinct from other intraductal neoplasms; however, its clinicopathologic characteristics, especially the frequency/signi ... Full text Link to item Cite

Endoscopic versus percutaneous drainage of post-operative peripancreatic fluid collections following pancreatic resection.

Journal Article HPB (Oxford) · April 2019 BACKGROUND: Post-operative peripancreatic fluid collection (PFC) is a common complication following pancreatic resection which can be managed with endoscopic or percutaneous drainage. METHODS: Patients who underwent either endoscopic or percutaneous draina ... Full text Link to item Cite

Perioperative Bundle to Reduce Surgical Site Infection after Pancreaticoduodenectomy: A Prospective Cohort Study.

Journal Article J Am Coll Surg · April 2019 BACKGROUND: Pancreaticoduodenectomy is historically associated with incisional surgical site infection (iSSI) rates between 15% and 20%. Prospective studies have been mixed with respect to the benefit of individual interventions directed at decreasing iSSI ... Full text Link to item Cite

Utility of Image Guidance in the Localization of Disappearing Colorectal Liver Metastases.

Journal Article J Gastrointest Surg · April 2019 BACKGROUND: Colorectal liver metastases that demonstrate a complete radiographic response during chemotherapy are increasingly common with advances in chemotherapy regimens and are described as disappearing liver metastases (DLMs). However, these DLMs ofte ... Full text Link to item Cite

Regional differences in gallbladder cancer pathogenesis: Insights from a multi-institutional comparison of tumor mutations.

Journal Article Cancer · February 15, 2019 BACKGROUND: Although rare in the United States, gallbladder cancer (GBCA) is a common cause of cancer death in some parts of the world. To investigate regional differences in pathogenesis and outcomes for GBCA, tumor mutations were analyzed from a sampling ... Full text Link to item Cite

Preoperative risk prediction for intraductal papillary mucinous neoplasms by quantitative CT image analysis.

Journal Article HPB (Oxford) · February 2019 BACKGROUND: Intraductal papillary mucinous neoplasms (IPMNs) are radiographically identifiable potential precursor lesions of pancreatic adenocarcinoma. While resection is recommended when main duct dilation is present, management of branch duct IPMN (BD-I ... Full text Link to item Cite

A perioperative multidisciplinary care bundle reduces surgical site infections in patients undergoing synchronous colorectal and liver resection.

Journal Article HPB (Oxford) · February 2019 BACKGROUND: Surgical site infections (SSIs) are a major cause of morbidity, mortality, and healthcare costs, and patients undergoing simultaneous colorectal/liver resections are at an especially high SSI risk. METHODS: Data were collected on all patients u ... Full text Link to item Cite

Hypophosphatemia as a Predictor of Organ-Specific Complications Following Gastrointestinal Surgery: Analysis of 8034 Patients.

Journal Article World J Surg · February 2019 BACKGROUND: Organ-specific complications (OSC) remain serious potential sequela of gastrointestinal surgery. Hypophosphatemia correlates with poor outcomes and may be a harbinger of OSC after gastrointestinal surgery. Our goal was to describe and evaluate ... Full text Link to item Cite

Correction to: Hypophosphatemia as a Predictor of Organ-Specific Complications Following Gastrointestinal Surgery: Analysis of 8034 Patients.

Journal Article World J Surg · February 2019 In the original version of this article, Martin R. Weiser's last name was spelled incorrectly. It is correct as reflected here. The original article has been updated. ... Full text Link to item Cite

Outcomes after Pancreatectomy with Routine Pasireotide Use.

Journal Article J Am Coll Surg · February 2019 BACKGROUND: Morbidity after pancreatectomy is commonly due to leakage of exocrine secretions resulting in abscess or pancreatic fistula (PF). Previously, we authored a double-blind randomized controlled trial demonstrating that perioperative pasireotide ad ... Full text Link to item Cite

Quantitative imaging features of pretreatment CT predict volumetric response to chemotherapy in patients with colorectal liver metastases.

Journal Article Eur Radiol · January 2019 OBJECTIVES: This study investigates whether quantitative image analysis of pretreatment CT scans can predict volumetric response to chemotherapy for patients with colorectal liver metastases (CRLM). METHODS: Patients treated with chemotherapy for CRLM (hep ... Full text Link to item Cite

CT radiomics to predict high-risk intraductal papillary mucinous neoplasms of the pancreas.

Journal Article Med Phys · November 2018 PURPOSE: Intraductal papillary mucinous neoplasms (IPMNs) are radiographically visible precursor lesions of pancreatic cancer. Despite standard criteria for assessing risk, only 18% of cysts are malignant at resection. Thus, a large number of patients unde ... Full text Link to item Cite

Prospective Evaluation of Germline Alterations in Patients With Exocrine Pancreatic Neoplasms.

Journal Article J Natl Cancer Inst · October 1, 2018 BACKGROUND: Identification of pathogenic germline alterations (PGAs) has important clinical and therapeutic implications in pancreas cancer. We performed comprehensive germline testing (GT) in an unselected prospective cohort of patients with exocrine panc ... Full text Link to item Cite

A preoperative prognostic model to predict surgical success in patients with perihilar cholangiocarcinoma.

Journal Article J Surg Oncol · September 2018 BACKGROUND: Patients with resectable perihilar cholangiocarcinoma (PHC) on imaging have a substantial risk of metastatic or locally advanced disease, incomplete (R1) resection, and 90-day mortality. Our aim was to develop a preoperative prognostic model to ... Full text Link to item Cite

Organoid Profiling Identifies Common Responders to Chemotherapy in Pancreatic Cancer.

Journal Article Cancer Discov · September 2018 Pancreatic cancer is the most lethal common solid malignancy. Systemic therapies are often ineffective, and predictive biomarkers to guide treatment are urgently needed. We generated a pancreatic cancer patient-derived organoid (PDO) library that recapitul ... Full text Link to item Cite

Preoperative Risk Score to Predict Occult Metastatic or Locally Advanced Disease in Patients with Resectable Perihilar Cholangiocarcinoma on Imaging.

Journal Article J Am Coll Surg · August 2018 BACKGROUND: Many patients with resectable perihilar cholangiocarcinoma (PHC) on imaging are diagnosed intraoperatively with occult metastatic or locally advanced disease, precluding a curative-intent resection. This study aimed to develop and validate a pr ... Full text Link to item Cite

Genetic And Morphological Evaluation (GAME) score for patients with colorectal liver metastases.

Journal Article Br J Surg · August 2018 BACKGROUND: This study sought to develop a clinical risk score for resectable colorectal liver metastasis (CRLM) by combining clinicopathological and clinically available biological indicators, including KRAS. METHODS: A cohort of patients who underwent re ... Full text Link to item Cite

Can physician gestalt predict survival in patients with resectable pancreatic adenocarcinoma?

Journal Article Abdom Radiol (NY) · August 2018 PURPOSE: Clinician gestalt may hold unexplored information that can be capitalized upon to improve existing nomograms. The study objective was to evaluate physician ability to predict 2-year overall survival (OS) in resected pancreatic ductal adenocarcinom ... Full text Link to item Cite

Multi-institutional Validation Study of Pancreatic Cyst Fluid Protein Analysis for Prediction of High-risk Intraductal Papillary Mucinous Neoplasms of the Pancreas.

Journal Article Ann Surg · August 2018 OBJECTIVE: Preliminary work by our group suggested that proteins within the pancreatic cyst fluid (CF) may discriminate degree of IPMN dysplasia. We sought to externally validate these markers and determine whether their inclusion in a preoperative clinica ... Full text Link to item Cite

Extracellular matrix proteins and carcinoembryonic antigen-related cell adhesion molecules characterize pancreatic duct fluid exosomes in patients with pancreatic cancer.

Journal Article HPB (Oxford) · July 2018 BACKGROUND: Exosomes are nanovesicles that have been shown to mediate carcinogenesis in pancreatic ductal adenocarcinoma (PDAC). Given the direct communication of pancreatic duct fluid with the tumor and its relative accessibility, we aimed to determine th ... Full text Link to item Cite

Progression Patterns in the Remnant Pancreas after Resection of Non-Invasive or Micro-Invasive Intraductal Papillary Mucinous Neoplasms (IPMN).

Journal Article Ann Surg Oncol · June 2018 BACKGROUND: Although IPMN are thought to represent a whole-gland disease, segmental resection remains the most frequently performed treatment. We sought to determine the rates, patterns, and predictors of IPMN progression in the pancreatic remnant followin ... Full text Link to item Cite

Brain Metastases in Pancreatic Ductal Adenocarcinoma: Assessment of Molecular Genotype-Phenotype Features-An Entity With an Increasing Incidence?

Journal Article Clin Colorectal Cancer · June 2018 PURPOSE: To assess clinical characteristics of patients with metastatic pancreas ductal adenocarcinoma (PDAC) and brain metastases (BM), and to assess somatic and germ-line molecular profiles where performed. PATIENTS AND METHODS: Patients with PDAC and BM ... Full text Link to item Cite

Actual 10-year survival after hepatic resection of colorectal liver metastases: what factors preclude cure?

Journal Article Surgery · June 2018 BACKGROUND: Hepatic resection of colorectal liver metastases is associated with long-term survival. This study analyzes actual 10-year survivors after resection of colorectal liver metastases, reports the observed rate of cure, and identifies factors that ... Full text Link to item Cite

European evidence-based guidelines on pancreatic cystic neoplasms.

Journal Article Gut · May 2018 Evidence-based guidelines on the management of pancreatic cystic neoplasms (PCN) are lacking. This guideline is a joint initiative of the European Study Group on Cystic Tumours of the Pancreas, United European Gastroenterology, European Pancreatic Club, Eu ... Full text Link to item Cite

Quantitative Imaging Features and Postoperative Hepatic Insufficiency: A Multi-Institutional Expanded Cohort.

Journal Article J Am Coll Surg · May 2018 BACKGROUND: Post-hepatectomy liver insufficiency (PHLI) is a significant cause of morbidity and mortality after liver resection. Quantitative imaging analysis using CT scans measures variations in pixel intensity related to perfusion. A preliminary study d ... Full text Link to item Cite

Survival Prediction in Pancreatic Ductal Adenocarcinoma by Quantitative Computed Tomography Image Analysis.

Journal Article Ann Surg Oncol · April 2018 BACKGROUND: Pancreatic cancer is a highly lethal cancer with no established a priori markers of survival. Existing nomograms rely mainly on post-resection data and are of limited utility in directing surgical management. This study investigated the use of ... Full text Link to item Cite

Protein biomarkers for early detection of pancreatic ductal adenocarcinoma: Progress and challenges

Journal Article Cancers · March 7, 2018 Approximately 75% of patients with pancreatic ductal adenocarcinoma are diagnosed with advanced cancer, which cannot be safely resected. The most commonly used biomarker CA19-9 has inadequate sensitivity and specificity for early detection, which we define ... Full text Cite

Prospective phase II trial of combination hepatic artery infusion and systemic chemotherapy for unresectable colorectal liver metastases: Long term results and curative potential.

Journal Article J Surg Oncol · March 2018 BACKGROUND/OBJECTIVES: Combination hepatic artery infusion (HAI) and systemic (SYS) chemotherapy for unresectable CRLM results in high tumor-response rates. This study represents an update of long-term survival and conversion to resectability in patients w ... Full text Link to item Cite

3D image guidance assisted identification of colorectal cancer liver metastases not seen on intraoperative ultrasound: results from a prospective trial.

Journal Article HPB (Oxford) · March 2018 BACKGROUND: Neoadjuvant treatment of colorectal liver metastases has become increasingly common, and while effective, often renders small metastases difficult to visualize on intraoperative US. The objective of this study was to determine the utility of a ... Full text Link to item Cite

Detection and localization of surgically resectable cancers with a multi-analyte blood test.

Journal Article Science · February 23, 2018 Earlier detection is key to reducing cancer deaths. Here, we describe a blood test that can detect eight common cancer types through assessment of the levels of circulating proteins and mutations in cell-free DNA. We applied this test, called CancerSEEK, t ... Full text Link to item Cite

The Impact of Primary Tumor Location on Long-Term Survival in Patients Undergoing Hepatic Resection for Metastatic Colon Cancer.

Journal Article Ann Surg Oncol · February 2018 BACKGROUND: The impact of primary tumor location on overall survival (OS), recurrence-free survival (RFS), and long-term outcomes has not been well established in patients undergoing potentially curative resection of colorectal liver metastases (CRLM). MET ... Full text Link to item Cite

Intraductal Papillary Mucinous Neoplasm of the Pancreas in Young Patients: Tumor Biology, Clinical Features, and Survival Outcomes.

Journal Article J Gastrointest Surg · February 2018 AIM: The aim of this paper is to describe the characteristics of intraductal papillary mucinous neoplasms (IPMNs) of the pancreas in young patients. METHODS: We evaluated 1693 patients from the Pancreatic Surgery Consortium who underwent resection for IPMN ... Full text Link to item Cite

The clinical utility of immunoglobulin G4 in the evaluation of autoimmune pancreatitis and pancreatic adenocarcinoma.

Journal Article HPB (Oxford) · February 2018 BACKGROUND: Elevation in the serum immunoglobulin-G4 (IgG4) level has been used as a diagnostic marker to distinguish autoimmune pancreatitis (AIP) from pancreatic ductal adenocarcinoma (PDAC), but its true utility is ill-defined. This study evaluates the ... Full text Link to item Cite

Characterization of hepatocellular adenoma and carcinoma using microRNA profiling and targeted gene sequencing.

Journal Article PLoS One · 2018 BACKGROUND: Hepatocellular adenomas (HCA) are benign liver tumors that may transform into hepatocellular carcinoma (HCC), but the molecular drivers of this transformation remain ill-defined. This study evaluates the molecular changes in HCA and HCC and in ... Full text Link to item Cite

Quantitative CT analysis for the preoperative prediction of pathologic grade in pancreatic neuroendocrine tumors

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2018 Pancreatic neuroendocrine tumors (PanNETs) account for approximately 5% of all pancreatic tumors, affecting one individual per million each year.1 PanNETs are difficult to treat due to biological variability from benign to highly malignant, indolent to ver ... Full text Cite

Development and Validation of a Multi-institutional Preoperative Nomogram for Predicting Grade of Dysplasia in Intraductal Papillary Mucinous Neoplasms (IPMNs) of the Pancreas: A Report from The Pancreatic Surgery Consortium.

Journal Article Ann Surg · January 2018 OBJECTIVE: Previous nomogram models for patients undergoing resection of intraductal papillary mucinous neoplasms (IPMNs) have been relatively small single-institutional series. Our objective was to improve upon these studies by developing and independentl ... Full text Link to item Cite

Pancreatic intraductal tubulopapillary neoplasm is genetically distinct from intraductal papillary mucinous neoplasm and ductal adenocarcinoma.

Journal Article Mod Pathol · December 2017 Intraductal tubulopapillary neoplasm is a relatively recently described member of the pancreatic intraductal neoplasm family. The more common member of this family, intraductal papillary mucinous neoplasm, often carries genetic alterations typical of pancr ... Full text Link to item Cite

Preoperative Prediction of Microvascular Invasion in Hepatocellular Carcinoma Using Quantitative Image Analysis.

Journal Article J Am Coll Surg · December 2017 BACKGROUND: Microvascular invasion (MVI) is a significant risk factor for early recurrence after resection or transplantation for hepatocellular carcinoma (HCC). Knowledge of MVI status would help guide treatment recommendations, but is generally identifie ... Full text Link to item Cite

The diagnosis and management of cystic lesions of the pancreas.

Journal Article Chin Clin Oncol · December 2017 Cystic lesions of the pancreas are radiographic findings that have a very broad histologic differential. This differential spans the spectrum from benign to cancerous, and includes non-neoplastic pseudocysts, benign neoplastic cysts, pre-malignant cysts, a ... Full text Link to item Cite

Identification of unique neoantigen qualities in long-term survivors of pancreatic cancer.

Journal Article Nature · November 23, 2017 Pancreatic ductal adenocarcinoma is a lethal cancer with fewer than 7% of patients surviving past 5 years. T-cell immunity has been linked to the exceptional outcome of the few long-term survivors, yet the relevant antigens remain unknown. Here we use gene ... Full text Link to item Cite

ACR Appropriateness Criteria® Staging of Pancreatic Ductal Adenocarcinoma.

Journal Article J Am Coll Radiol · November 2017 Pancreatic adenocarcinoma is associated with poor overall prognosis. Complete surgical resection is the only possible option for cure. As such, increasingly complex surgical techniques including sophisticated vascular reconstruction are being used. Continu ... Full text Link to item Cite

Utility of Serum Inflammatory Markers for Predicting Microvascular Invasion and Survival for Patients with Hepatocellular Carcinoma.

Journal Article Ann Surg Oncol · November 2017 BACKGROUND: Preoperative serum inflammatory markers have been correlated with outcome after resection of hepatocellular carcinoma (HCC), but studies have had conflicting results. This study aimed to evaluate the association of six inflammatory markers with ... Full text Link to item Cite

Real-Time Genomic Profiling of Pancreatic Ductal Adenocarcinoma: Potential Actionability and Correlation with Clinical Phenotype.

Journal Article Clin Cancer Res · October 15, 2017 Purpose: Molecular profiling in cancer has identified potential actionable drug targets that have prompted attempts to discover clinically validated biomarkers to guide therapeutic decision-making and enrollment to clinical trials. We evaluated whether com ... Full text Link to item Cite

Hypophosphatemia after Hepatectomy or Pancreatectomy: Role of the Nicotinamide Phosphoribosyltransferase.

Journal Article J Am Coll Surg · October 2017 BACKGROUND: Postoperative hypophosphatemia is common and is associated with a lower risk of liver failure after hepatectomy, but higher morbidity after pancreatectomy. Whether different physiologic mechanisms underlie the hypophosphatemia associated with t ... Full text Link to item Cite

Prediction of Hepatocellular Carcinoma Recurrence Beyond Milan Criteria After Resection: Validation of a Clinical Risk Score in an International Cohort.

Conference Ann Surg · October 2017 OBJECTIVE: This study aims to validate a previously reported recurrence clinical risk score (CRS). SUMMARY OF BACKGROUND DATA: Salvage transplantation after hepatocellular carcinoma (HCC) resection is limited to patients who recur within Milan criteria (MC ... Full text Link to item Cite

Natural History of Patients Followed Radiographically with Mucinous Cysts of the Pancreas.

Journal Article J Gastrointest Surg · October 2017 OBJECTIVE: The aim of this study was to evaluate the outcome of patients presumed to have mucinous cysts of the pancreas who were initially selected for radiographic surveillance. METHODS: Patients with a pancreatic cyst and a measured cyst fluid carcinoem ... Full text Link to item Cite

Combined circulating tumor DNA and protein biomarker-based liquid biopsy for the earlier detection of pancreatic cancers.

Journal Article Proc Natl Acad Sci U S A · September 19, 2017 The earlier diagnosis of cancer is one of the keys to reducing cancer deaths in the future. Here we describe our efforts to develop a noninvasive blood test for the detection of pancreatic ductal adenocarcinoma. We combined blood tests for KRAS gene mutati ... Full text Link to item Cite

The oral microbiota in patients with pancreatic cancer, patients with IPMNs, and controls: a pilot study.

Journal Article Cancer Causes Control · September 2017 PURPOSE: Poor oral health appears to be a risk factor for pancreatic cancer, possibly implicating the oral microbiota. In this pilot study, we evaluated the characteristics of the oral microbiota in patients with pancreatic ductal adenocarcinoma (PDAC), in ... Full text Link to item Cite

Postoperative Liver Failure Risk Score: Identifying Patients with Resectable Perihilar Cholangiocarcinoma Who Can Benefit from Portal Vein Embolization.

Journal Article J Am Coll Surg · September 2017 BACKGROUND: Major liver resection for perihilar cholangiocarcinoma (PHC) is associated with a 22% to 33% postoperative liver failure incidence. The aim of this study was analyze the predictive value of future liver remnant (FLR) volume for postoperative li ... Full text Link to item Cite

Should Patients With Cystic Lesions of the Pancreas Undergo Long-term Radiographic Surveillance?: Results of 3024 Patients Evaluated at a Single Institution.

Journal Article Ann Surg · September 2017 OBJECTIVE: In 2015, the American Gastroenterological Association recommended the discontinuation of radiographic surveillance after 5 years for patients with stable pancreatic cysts. The current study evaluated the yield of continued surveillance of pancre ... Full text Link to item Cite

Computed Tomography Image Texture: A Noninvasive Prognostic Marker of Hepatic Recurrence After Hepatectomy for Metastatic Colorectal Cancer.

Journal Article Ann Surg Oncol · September 2017 BACKGROUND: Recurrence after resection of colorectal liver metastases (CRLMs) occurs in up to 75% of patients. Preoperative prediction of hepatic recurrence may inform therapeutic strategies at the time of initial resection. Texture analysis (TA) is an est ... Full text Link to item Cite

Predicting Residual Disease in Incidental Gallbladder Cancer: Risk Stratification for Modified Treatment Strategies.

Journal Article J Gastrointest Surg · August 2017 INTRODUCTION: Re-operation is advised for patients with T1b or greater incidental gallbladder cancer (GBCA). The presence of residual disease (RD) impacts resectability, chemotherapy, and survival. This study created a preoperative model to predict RD at r ... Full text Link to item Cite

O6-Methylguanine DNA Methyltransferase Status Does Not Predict Response or Resistance to Alkylating Agents in Well-Differentiated Pancreatic Neuroendocrine Tumors.

Journal Article Pancreas · July 2017 OBJECTIVES: Alkylating agents have activity in well-differentiated pancreatic neuroendocrine tumors (WD panNETs). In glioblastoma multiforme, decreased activity of O-methylguanine DNA methyltransferase (MGMT) predicts response; in panNETs, MGMT relevance i ... Full text Link to item Cite

Tumor-Associated Macrophage Infiltration in Colorectal Cancer Liver Metastases is Associated With Better Outcome.

Journal Article Ann Surg Oncol · July 2017 BACKGROUND: Tumor-associated macrophages (TAMs) support growth in most human cancers, with the notable exception of colorectal adenocarcinoma, in which TAM infiltration of primary tumors is correlated with a better outcome. The importance of TAMs in colore ... Full text Link to item Cite

Perioperative Hepatic Arterial Infusion Pump Chemotherapy Is Associated With Longer Survival After Resection of Colorectal Liver Metastases: A Propensity Score Analysis.

Journal Article J Clin Oncol · June 10, 2017 Purpose To investigate whether perioperative hepatic arterial infusion pump chemotherapy (HAI) was associated with overall survival (OS) in patients who had a complete resection of colorectal liver metastases (CLM). Methods Patients who underwent a complet ... Full text Link to item Cite

Pancreatic cancer

Chapter · June 10, 2017 Cite

Recurrence patterns following irreversible electroporation for hepatic malignancies.

Journal Article J Surg Oncol · May 2017 BACKGROUND: Irreversible electroporation (IRE) has emerged as a novel, safe ablative therapy for peri-vascular lesions. However, there remains a paucity of data on long-term outcomes. METHODS: We identified patients who underwent open IRE (1/2011-6/2015) f ... Full text Link to item Cite

Systemic Chemotherapy Combined with Resection for Locally Advanced Gallbladder Carcinoma: Surgical and Survival Outcomes.

Conference J Am Coll Surg · May 2017 BACKGROUND: Preoperative chemotherapy is a strategy for converting to resection and/or assessing disease biology before operation. The utility of such an approach in gallbladder carcinoma (GBCA) is unknown. This study evaluated outcomes of GBCA patients tr ... Full text Link to item Cite

Percutaneous Peritoneal Lavage for the Rapid Staging of Gastric and Pancreatic Cancer.

Journal Article Ann Surg Oncol · May 2017 BACKGROUND: Positive peritoneal cytology is classified as M1 disease in gastric and pancreatic cancer. While peritoneal cytology is typically obtained by laparoscopic peritoneal lavage, this study sought to examine the feasibility and safety of performing ... Full text Link to item Cite

Actual 10-Year Survivors After Resection of Hepatocellular Carcinoma.

Journal Article Ann Surg Oncol · May 2017 BACKGROUND: Resection of hepatocellular carcinoma (HCC) offers a chance of cure, but recurrence is common and survival is often limited. The clinical and pathological characteristics of long-term survivors have not been well studied. METHODS: We retrospect ... Full text Link to item Cite

Evolving application of minimally invasive cancer operations at a tertiary cancer center.

Journal Article J Surg Oncol · March 2017 BACKGROUND: Patients and providers are increasingly interested in the utilization, safety, and efficacy of minimally invasive surgery (MIS). We reviewed 11 years of MIS resections (laparoscopic and robotic) for intra-abdominal malignancies. METHODS: Patien ... Full text Link to item Cite

Minimally invasive distal pancreatectomy.

Journal Article HPB (Oxford) · March 2017 BACKGROUND: The first International conference on Minimally Invasive Pancreas Resection was arranged in conjunction with the annual meeting of the International Hepato-Pancreato-Biliary Association (IHPBA), in Sao Paulo, Brazil on April 19th 2016. The pres ... Full text Link to item Cite

The 2016 update of the International Study Group (ISGPS) definition and grading of postoperative pancreatic fistula: 11 Years After.

Journal Article Surgery · March 2017 BACKGROUND: In 2005, the International Study Group of Pancreatic Fistula developed a definition and grading of postoperative pancreatic fistula that has been accepted universally. Eleven years later, because postoperative pancreatic fistula remains one of ... Full text Link to item Cite

Intraductal Tubulopapillary Neoplasm of the Pancreas: A Clinicopathologic and Immunohistochemical Analysis of 33 Cases.

Journal Article Am J Surg Pathol · March 2017 Intraductal tubulopapillary neoplasm (ITPN) is a relatively recently described member of the pancreatic intraductal neoplasm family. Thus, the literature on its histologic and immunohistochemical features, clinical behavior, and its similarities and differ ... Full text Link to item Cite

Chemotherapy and intensity-modulated radiation therapy for locally advanced pancreatic cancer achieves a high rate of R0 resection.

Journal Article Acta Oncol · March 2017 BACKGROUND: To assess local control, survival and conversion to resectability among locally advanced pancreatic cancer (LAPC) patients treated with induction chemotherapy (ICT) followed by chemoradiotherapy treatment using intensity-modulated radiation the ... Full text Link to item Cite

Treatment Response and Outcomes of Grade 3 Pancreatic Neuroendocrine Neoplasms Based on Morphology: Well Differentiated Versus Poorly Differentiated.

Journal Article Pancreas · March 2017 OBJECTIVES: Emerging data suggest that not all grade 3 (G3) pancreatic neuroendocrine neoplasms (panNENs) behave the same; tumor differentiation may predict outcome. METHODS: Patients with G3 panNENs treated at our institution between 1999 and 2014 were id ... Full text Link to item Cite

Mutation location on the RAS oncogene affects pathologic features and survival after resection of colorectal liver metastases.

Journal Article Cancer · February 15, 2017 BACKGROUND: In the past 3 decades, a better understanding of gene mutations and their role in carcinogenesis has led to improvement in our ability to treat patients with metastatic disease. The objective of the current study was to determine whether the lo ... Full text Link to item Cite

Operative morbidity and survival following hepatectomy for colorectal liver metastasis in octogenarians: a contemporary case matched series.

Journal Article HPB (Oxford) · February 2017 BACKGROUND: Clinical outcomes of octogenarians undergoing hepatectomy for colorectal liver metastases (CRLM) are poorly characterized. The current study evaluated operative morbidity, mortality and survival outcomes among a contemporary cohort of octogenar ... Full text Link to item Cite

Preliminary study of tumor heterogeneity in imaging predicts two year survival in pancreatic cancer patients.

Journal Article PLoS One · 2017 Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers in the United States with a five-year survival rate of 7.2% for all stages. Although surgical resection is the only curative treatment, currently we are unable to differentiate betwe ... Full text Link to item Cite

Quantification of CT images for the classification of high- and low-risk pancreatic cysts

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2017 Pancreatic cancer is the most lethal cancer with an overall 5-year survival rate of 7%1 due to the late stage at diagnosis and the ineffectiveness of current therapeutic strategies. Given the poor prognosis, early detection at a pre-cancerous stage is the ... Full text Cite

Surgical Strategy and Outcomes in Duodenal Gastrointestinal Stromal Tumor.

Journal Article Ann Surg Oncol · January 2017 BACKGROUND: The surgical management of duodenal gastrointestinal stromal tumors (DGIST) is poorly characterized. Limited resection may be technically feasible and oncologically safe, but anatomic considerations may compromise the resection margins due to t ... Full text Link to item Cite

The Cost of Postoperative Pancreatic Fistula Versus the Cost of Pasireotide: Results from a Prospective Randomized Trial.

Journal Article Ann Surg · January 2017 OBJECTIVE: The objective of this study was to determine the costs of clinically significant postoperative pancreatic fistula (POPF) and to evaluate the cost-effectiveness of routine pasireotide use. SUMMARY OF BACKGROUND DATA: We recently completed a prosp ... Full text Link to item Cite

Multi-institutional Validation Study of the American Joint Commission on Cancer (8th Edition) Changes for T and N Staging in Patients With Pancreatic Adenocarcinoma.

Journal Article Ann Surg · January 2017 OBJECTIVE: The aim of this study was to evaluate and validate the proposed 8th edition American Joint Committee on Cancer (AJCC) system for T and N staging of pancreatic adenocarcinoma. SUMMARY OF BACKGROUND DATA: Investigators have questioned the clinical ... Full text Link to item Cite

Colorectal Cancer Liver Metastases and Concurrent Extrahepatic Disease Treated With Resection.

Journal Article Ann Surg · January 2017 OBJECTIVE: The aim of the study was to evaluate outcomes after resection of colorectal liver metastases (CRLM) and concurrent extrahepatic disease (EHD), and to define prognostic factors. BACKGROUND: There is increasing evidence to support resection of liv ... Full text Link to item Cite

Cyst Fluid Analysis in Pancreatic Intraductal Papillary Mucinous Neoplasms.

Journal Article Clin Cancer Res · October 15, 2016 Pancreatic intraductal papillary mucinous neoplasms (IPMN) are surgically treatable cancer precursors, if high-risk features can be identified. Analysis of proteins and genes in cyst fluid helps diagnostically, but prior biomarkers had limited ability to d ... Full text Link to item Cite

Prospective Randomized Controlled Trial of Liberal Vs Restricted Perioperative Fluid Management in Patients Undergoing Pancreatectomy.

Conference Ann Surg · October 2016 OBJECTIVE: The aim of this study is to examine, by a prospective randomized controlled trial, the influence of liberal (LIB) vs restricted (RES) perioperative fluid administration on morbidity following pancreatectomy. SUMMARY OF BACKGROUND DATA: Randomize ... Full text Link to item Cite

Circulating plasma levels of MicroRNA-21 and MicroRNA-221 are potential diagnostic markers for primary intrahepatic cholangiocarcinoma

Journal Article PLoS ONE · September 1, 2016 Background: MicroRNAs (miRNAs) are potential biomarkers in various malignancies. We aim to characterize miRNA expression in intrahepatic cholangiocarcinoma (ICC) and identify circulating plasma miRNAs with potential diagnostic and prognostic utility. Metho ... Full text Cite

Pancreatic Cancer Chemoprevention Translational Workshop: Meeting Report.

Conference Pancreas · September 2016 Pancreatic cancer is the fourth leading cause of cancer related deaths in the United States with a 5-year survival rate of less than 10%. The Division of Cancer Prevention of the National Cancer Institute sponsored the Pancreatic Cancer Chemoprevention Tra ... Full text Link to item Cite

Recurrence Patterns and Disease-Free Survival after Resection of Intrahepatic Cholangiocarcinoma: Preoperative and Postoperative Prognostic Models.

Conference J Am Coll Surg · September 2016 BACKGROUND: Liver resection is the most effective treatment for intrahepatic cholangiocarcinoma. Recurrent disease is frequent; however, recurrence patterns are ill-defined and prognostic models are lacking. STUDY DESIGN: A primary cohort of 189 patients w ... Full text Link to item Cite

The oncocytic subtype is genetically distinct from other pancreatic intraductal papillary mucinous neoplasm subtypes.

Conference Mod Pathol · September 2016 In 2010, the World Health Organization reclassified the entity originally described as intraductal oncocytic papillary neoplasm as the 'oncocytic subtype' of intraductal papillary mucinous neoplasm. Although several key molecular alterations of other intra ... Full text Link to item Cite

Locally Advanced, Unresectable Pancreatic Cancer: American Society of Clinical Oncology Clinical Practice Guideline.

Journal Article J Clin Oncol · August 1, 2016 PURPOSE: To provide evidence-based recommendations to oncologists and others for treatment of patients with locally advanced, unresectable pancreatic cancer. METHODS: American Society of Clinical Oncology convened an Expert Panel of medical oncology, radia ... Full text Link to item Cite

Use of positron emission tomography scan response to guide treatment change for locally advanced gastric cancer: The Memorial Sloan Kettering Cancer Center experience

Journal Article Journal of Gastrointestinal Oncology · August 1, 2016 Background: Early metabolic response on 18-fluorodeoxyglucose-positron emission tomography (FDG-PET) during neoadjuvant chemotherapy is PET non-responders have poor outcomes whether continuing chemotherapy or proceeding directly to surgery. Use of PET may ... Full text Cite

Postoperative Mortality after Liver Resection for Perihilar Cholangiocarcinoma: Development of a Risk Score and Importance of Biliary Drainage of the Future Liver Remnant.

Conference J Am Coll Surg · August 2016 BACKGROUND: Liver surgery for perihilar cholangiocarcinoma (PHC) is associated with postoperative mortality ranging from 5% to 18%. The aim of this study was to develop a preoperative risk score for postoperative mortality after liver resection for PHC, an ... Full text Link to item Cite

Weight Loss, Diabetes, Fatigue, and Depression Preceding Pancreatic Cancer.

Journal Article Pancreas · August 2016 OBJECTIVES: We aimed to determine the severity and co-occurrence of established and potential paraneoplastic conditions in pancreatic cancer (weight loss, new onset diabetes, fatigue, and depression) and their relation to patient characteristics. METHODS: ... Full text Link to item Cite

Long-term oncologic outcomes for simultaneous resection of synchronous metastatic liver and primary colorectal cancer.

Journal Article Surgery · July 2016 BACKGROUND: Twenty-five percent of patients with colorectal cancer present with simultaneous liver metastasis. Complete resection is the only potential curative treatment. Due to improvements in operative and perioperative management, simultaneous liver an ... Full text Link to item Cite

Health-Related Quality of Life After Pancreatectomy: Results From a Randomized Controlled Trial.

Journal Article Ann Surg Oncol · July 2016 BACKGROUND: A recent prospective randomized trial demonstrated that prophylactic pasireotide reduces the incidence of pancreatic complications (PC) after resection. This secondary analysis aimed to describe quality of life (QoL) before and after resection, ... Full text Link to item Cite

Hepatic Resection or Ablation for Isolated Breast Cancer Liver Metastasis: A Case-control Study With Comparison to Medically Treated Patients.

Journal Article Ann Surg · July 2016 OBJECTIVE: To evaluate the efficacy of surgical treatment for patients with isolated breast cancer liver metastases (BCLM). BACKGROUND: Single-arm retrospective studies have shown promising results associated with surgery for isolated BCLM; however, this t ... Full text Link to item Cite

Randomized Trial of Hepatic Artery Embolization for Hepatocellular Carcinoma Using Doxorubicin-Eluting Microspheres Compared With Embolization With Microspheres Alone.

Journal Article J Clin Oncol · June 10, 2016 PURPOSE: Transarterial chemoembolization is accepted therapy for hepatocellular carcinoma (HCC). No randomized trial has demonstrated superiority of chemoembolization compared with embolization, and the role of chemotherapy remains unclear. This randomized ... Full text Link to item Cite

Pancreatic cyst fluid concentration of high-mobility group A2 protein acts as a differential biomarker of dysplasia in intraductal papillary mucinous neoplasm.

Journal Article Gastrointest Endosc · June 2016 BACKGROUND AND AIMS: No reliable cyst fluid biomarkers exist that allow preoperative identification of patients with intraductal papillary mucinous neoplasms (IPMNs) and high-risk pathology. High-mobility group (HMG) A2 protein has been demonstrated to be ... Full text Link to item Cite

Robotic Liver Resection: A Case-Matched Comparison.

Journal Article World J Surg · June 2016 BACKGROUND: In recent years, increasingly sophisticated tools have allowed for more complex robotic surgery. Robotic hepatectomy, however, is still in its infancy. Our goals were to examine the adoption of robotic hepatectomy and to compare outcomes betwee ... Full text Link to item Cite

FOLFIRINOX for locally advanced pancreatic cancer: a systematic review and patient-level meta-analysis.

Journal Article Lancet Oncol · June 2016 BACKGROUND: 35% of patients with pancreatic cancer have unresectable locally advanced disease at diagnosis. Several studies have examined systemic chemotherapy with FOLFIRINOX (leucovorin and fluorouracil plus irinotecan and oxaliplatin) in patients with l ... Full text Link to item Cite

A Validated Prognostic Multigene Expression Assay for Overall Survival in Resected Colorectal Cancer Liver Metastases.

Journal Article Clin Cancer Res · May 15, 2016 PURPOSE: Risk stratification after surgery for colorectal cancer liver metastases (CRLM) is achieved using clinicopathologic variables, however, is of limited accuracy. We sought to derive and externally validate a multigene expression assay prognostic of ... Full text Link to item Cite

A Pilot Study Evaluating Serum MMP7 as a Preoperative Prognostic Marker for Pancreatic Ductal Adenocarcinoma Patients.

Journal Article J Gastrointest Surg · May 2016 BACKGROUND: Current preoperative risk stratification modalities for pancreatic ductal adenocarcinoma (PDA) patients are inadequate. Elevated serum matrix metalloproteinase 7 (MMP7) is associated with metastatic PDA. We evaluated preoperative MMP7 level as ... Full text Link to item Cite

Human Trial of a Genetically Modified Herpes Simplex Virus for Rapid Detection of Positive Peritoneal Cytology in the Staging of Pancreatic Cancer.

Journal Article EBioMedicine · May 2016 INTRODUCTION: Patients with peritoneal dissemination of pancreatic adenocarcinoma do not benefit from surgical resection, but radiologic and cytologic detection of peritoneal cancer lack sensitivity. This trial sought to determine if an oncolytic virus may ... Full text Link to item Cite

Time-to-Surgery and Survival Outcomes in Resectable Colorectal Liver Metastases: A Multi-Institutional Evaluation.

Journal Article J Am Coll Surg · May 2016 BACKGROUND: Resection of colorectal liver metastases (CRLM) is associated with improved survival; however, the impact of time to resection on survival is unknown. The current multi-institutional study sought to evaluate the influence of time from diagnosis ... Full text Link to item Cite

Recurrence and Survival After Resection of Small Intraductal Papillary Mucinous Neoplasm-associated Carcinomas (≤20-mm Invasive Component): A Multi-institutional Analysis.

Journal Article Ann Surg · April 2016 BACKGROUND: Early invasive carcinoma may be encountered in association with intraductal papillary mucinous neoplasms (IPMNs) of the pancreas. The natural history of these early invasive lesions is unknown. METHODS: Pancreatic surgical databases from 4 high ... Full text Link to item Cite

Therapeutic Approach to Cystic Neoplasms of the Pancreas.

Journal Article Surg Oncol Clin N Am · April 2016 Management of cystic neoplasms of the pancreas is challenging as it relies on radiologic and cyst fluid markers to discriminate between benign and pre-cancerous lesions, however their ability to predict malignancy is limited. While asymptomatic serous cyst ... Full text Link to item Cite

Updated long-term survival for patients with metastatic colorectal cancer treated with liver resection followed by hepatic arterial infusion and systemic chemotherapy.

Journal Article J Surg Oncol · April 2016 BACKGROUND AND OBJECTIVES: Patients who undergo liver resection for metastatic colorectal cancer (mCRC) have reported 5-year survivals ranging from 25% to 50%. The current study updated long-term survival for patients with resected liver metastases treated ... Full text Link to item Cite

Symptomatic Perihepatic Fluid Collections After Hepatic Resection in the Modern Era.

Journal Article J Gastrointest Surg · April 2016 BACKGROUND: Improvements in liver surgery have led to decreased mortality rates. Symptomatic perihepatic collections (SPHCs) requiring percutaneous drainage remain a significant source of morbidity. STUDY DESIGN: A single institution's prospectively mainta ... Full text Link to item Cite

Observation versus Resection for Small Asymptomatic Pancreatic Neuroendocrine Tumors: A Matched Case-Control Study.

Journal Article Ann Surg Oncol · April 2016 OBJECTIVE: To analyze the natural history of small asymptomatic pancreatic neuroendocrine tumors (PanNET) and to present a matched comparison between groups who underwent either initial observation or resection. Management approach for small PanNET is unce ... Full text Link to item Cite

Unresectable intrahepatic cholangiocarcinoma: Systemic plus hepatic arterial infusion chemotherapy is associated with longer survival in comparison with systemic chemotherapy alone.

Journal Article Cancer · March 1, 2016 BACKGROUND: Intrahepatic cholangiocarcinoma (ICC) is associated with poor survival. This study compared the outcomes of patients with unresectable ICC treated with hepatic arterial infusion (HAI) plus systemic chemotherapy (SYS) with the outcomes of patien ... Full text Link to item Cite

Well-Differentiated Neuroendocrine Tumors with a Morphologically Apparent High-Grade Component: A Pathway Distinct from Poorly Differentiated Neuroendocrine Carcinomas.

Journal Article Clin Cancer Res · February 15, 2016 PURPOSE: Most well-differentiated neuroendocrine tumors (WD-NET) of the enteropancreatic system are low-intermediate grade (G1, G2). Elevated proliferation demonstrated by either a brisk mitotic rate (>20/10 high power fields) or high Ki-67 index (>20%) de ... Full text Link to item Cite

Postoperative complications and overall survival after pancreaticoduodenectomy for pancreatic ductal adenocarcinoma.

Journal Article J Surg Oncol · February 2016 INTRODUCTION: Pancreaticoduodenectomy (PD) performed for pancreatic ductal adenocarcinoma (PDA) has a postoperative morbidity of 40-50%. In this study, we analyzed the impact of high grade complications after PD for PDA on overall survival. METHODS: A tota ... Full text Link to item Cite

Trans-arterial embolization for hepatocellular carcinoma: Doxorubicin is not necessary

Journal Article Translational Cancer Research · January 1, 2016 Full text Cite

A Gastric Glycoform of MUC5AC Is a Biomarker of Mucinous Cysts of the Pancreas.

Journal Article PLoS One · 2016 Molecular indicators to specify the risk posed by a pancreatic cyst would benefit patients. Previously we showed that most cancer-precursor cysts, termed mucinous cysts, produce abnormal glycoforms of the proteins MUC5AC and endorepellin. Here we sought to ... Full text Link to item Cite

Imaging comparison of tubular and colloid pancreatic adenocarcinoma arising from intraductal papillary mucinous neoplasm on multidetector CT.

Journal Article Clin Imaging · 2016 PURPOSE: This study aims to compare tubular pancreatic ductal adenocarcinoma (tPDAC) and colloid subtype pancreatic ductal adenocarcinoma (cPDAC) associated with intraductal papillary mucinous neoplasms (IPMNs) on computed tomography. METHODS: An instituti ... Full text Link to item Cite

Texture analysis for survival prediction of pancreatic ductal adenocarcinoma patients with neoadjuvant chemotherapy

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2016 Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer-related death in the United States. The five-year survival rate for all stages is approximately 6%, and approximately 2% when presenting with distant disease.1 Only 10-20% of all ... Full text Cite

The Role of Biliary Carcinoembryonic Antigen-Related Cellular Adhesion Molecule 6 (CEACAM6) as a Biomarker in Cholangiocarcinoma.

Journal Article PLoS One · 2016 OBJECTIVE: The aim of the present study is to determine if CEACAM6 can be detected in the bile of patients with biliary cancer and can serve as a diagnostic biomarker for cholangiocarcinoma. SUMMARY BACKGROUND DATA: Distinguishing bile duct carcinoma from ... Full text Link to item Cite

Intensity modulated radiation therapy reduces gastrointestinal toxicity in locally advanced pancreas cancer.

Journal Article Pract Radiat Oncol · 2016 PURPOSE: We compared gastrointestinal (GI) and hematologic toxicity in patients with locally advanced pancreas cancer (LAPC) undergoing definitive chemoradiation using intensity modulated radiation therapy (IMRT) or 3-dimensional conformal radiation therap ... Full text Link to item Cite

Cystic Neoplasms of the Pancreas.

Journal Article Annu Rev Med · 2016 Cystic neoplasms of the pancreas are being identified at an increasing frequency largely due to the increased use of abdominal cross-sectional imaging. These neoplasms represent a heterogeneous group of tumors with various genetic alterations, molecular fe ... Full text Link to item Cite

Pathologic Evaluation and Reporting of Intraductal Papillary Mucinous Neoplasms of the Pancreas and Other Tumoral Intraepithelial Neoplasms of Pancreatobiliary Tract: Recommendations of Verona Consensus Meeting.

Journal Article Ann Surg · January 2016 BACKGROUND: There are no established guidelines for pathologic diagnosis/reporting of intraductal papillary mucinous neoplasms (IPMNs). DESIGN: An international multidisciplinary group, brought together by the Verona Pancreas Group in Italy-2013, was taske ... Full text Link to item Cite

Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks in 188 countries, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013.

Journal Article Lancet · December 5, 2015 BACKGROUND: The Global Burden of Disease, Injuries, and Risk Factor study 2013 (GBD 2013) is the first of a series of annual updates of the GBD. Risk factor quantification, particularly of modifiable risk factors, can help to identify emerging threats to p ... Full text Link to item Cite

Percutaneous Preoperative Biliary Drainage for Resectable Perihilar Cholangiocarcinoma: No Association with Survival and No Increase in Seeding Metastases.

Journal Article Ann Surg Oncol · December 2015 BACKGROUND: Endoscopic biliary drainage (EBD) and percutaneous transhepatic biliary drainage (PTBD) are both used to resolve jaundice before surgery for perihilar cholangiocarcinoma (PHC). PTBD has been associated with seeding metastases. The aim of this s ... Full text Link to item Cite

Recurrence Rate and Pattern of Perihilar Cholangiocarcinoma after Curative Intent Resection.

Conference J Am Coll Surg · December 2015 BACKGROUND: The aim of this study was to investigate the rate and pattern of recurrence after curative intent resection of perihilar cholangiocarcinoma (PHC). STUDY DESIGN: Patients were included from 2 prospectively maintained databases. Recurrences were ... Full text Link to item Cite

Tumor-associated Neutrophils and Malignant Progression in Intraductal Papillary Mucinous Neoplasms: An Opportunity for Identification of High-risk Disease.

Conference Ann Surg · December 2015 OBJECTIVES: To evaluate the association of tumor-associated neutrophils (TANs) with malignant progression in intraductal papillary mucinous neoplasms (IPMNs) and to study the cyst fluid from these lesions for biomarkers of the inflammation-carcinogenesis a ... Full text Link to item Cite

Early trends in serum phosphate and creatinine levels are associated with mortality following major hepatectomy.

Conference HPB (Oxford) · December 2015 BACKGROUND: Mortality after major hepatectomy remains high and is frequently related to post-hepatectomy liver failure (PHLF). Other than pre-existing liver disease and a small future liver remnant, few patient factors or early postoperative indicators ide ... Full text Link to item Cite

Preoperative biliary drainage in perihilar cholangiocarcinoma: identifying patients who require percutaneous drainage after failed endoscopic drainage.

Journal Article Endoscopy · December 2015 BACKGROUND AND STUDY AIMS: Preoperative biliary drainage is often initiated with endoscopic retrograde cholangiopancreatography (ERCP) in patients with potentially resectable perihilar cholangiocarcinoma (PHC), but additional percutaneous transhepatic cath ... Full text Link to item Cite

A combination of molecular markers and clinical features improve the classification of pancreatic cysts.

Journal Article Gastroenterology · November 2015 BACKGROUND & AIMS: The management of pancreatic cysts poses challenges to both patients and their physicians. We investigated whether a combination of molecular markers and clinical information could improve the classification of pancreatic cysts and manag ... Full text Link to item Cite

Intraductal Papillary Mucinous Neoplasms and the Risk of Diabetes Mellitus in Patients Undergoing Resection Versus Observation.

Journal Article J Gastrointest Surg · November 2015 OBJECTIVE: The aim of this study is to determine the prevalence of diabetes mellitus (DM) in patients with intraductal papillary mucinous neoplasm of the pancreas (IPMN) and compare rates of new/progressive DM between IPMN patients undergoing pancreatectom ... Full text Link to item Cite

Central hepatectomy versus extended hepatectomy for liver malignancy: a matched cohort comparison.

Journal Article HPB (Oxford) · November 2015 OBJECTIVE: To compare surgical outcomes between matched central hepatectomy (CH) and extended hepatectomy (EH) groups. BACKGROUND: Surgical choices for centrally located liver tumours are limited. The traditional EH harbours substantial risks, whereas CH i ... Full text Link to item Cite

Segment and fit thresholding: a new method for image analysis applied to microarray and immunofluorescence data.

Journal Article Anal Chem · October 6, 2015 Experiments involving the high-throughput quantification of image data require algorithms for automation. A challenge in the development of such algorithms is to properly interpret signals over a broad range of image characteristics, without the need for m ... Full text Link to item Cite

Cystic Lesions of the Pancreas: Observe or Operate

Journal Article Indian Journal of Surgery · October 1, 2015 Full text Cite

The accuracy of pre-operative imaging in the management of hepatic cysts.

Conference HPB (Oxford) · October 2015 BACKGROUND: Biliary cystic tumours (BCT) [biliary cystadenoma (BCA) and cystadenocarcinoma (BCAC)] warrant complete resection. Simple liver cysts (SLC) require fenestration when symptomatic. Distinguishing between BCT and atypical SLC with pre-operative im ... Full text Link to item Cite

FOLFIRINOX Induction Therapy for Stage 3 Pancreatic Adenocarcinoma.

Journal Article Ann Surg Oncol · October 2015 BACKGROUND: Reports show that FOLFIRINOX therapy for pancreatic ductal adenocarcinoma (PDAC) results in objective response rates two to threefold higher than those of other regimens. This study aimed to assess response and resection rates for locally unres ... Full text Link to item Cite

Resection margin and survival in 2368 patients undergoing hepatic resection for metastatic colorectal cancer: surgical technique or biologic surrogate?

Conference Ann Surg · September 2015 OBJECTIVES: The impact of margin width on overall survival (OS) in the context of other prognostic factors after resection for colorectal liver metastases is unclear. We evaluated the relationship between resection margin and OS utilizing high-resolution h ... Full text Link to item Cite

Survival after resection of perihilar cholangiocarcinoma-development and external validation of a prognostic nomogram.

Journal Article Ann Oncol · September 2015 BACKGROUND: The objective of this study was to derive and validate a prognostic nomogram to predict disease-specific survival (DSS) after a curative intent resection of perihilar cholangiocarcinoma (PHC). PATIENTS AND METHODS: A nomogram was developed from ... Full text Link to item Cite

Positive postoperative CEA is a strong predictor of recurrence for patients after resection for colorectal liver metastases.

Journal Article Ann Surg Oncol · September 2015 BACKGROUND: The role of carcinoembryonic antigen (CEA) in surveillance and follow-up of patients with colorectal cancer continues to be debated. The objective of this study was to assess the utility of postoperative CEA as a predictor of recurrence for pat ... Full text Link to item Cite

Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013.

Journal Article Lancet · August 22, 2015 BACKGROUND: Up-to-date evidence about levels and trends in disease and injury incidence, prevalence, and years lived with disability (YLDs) is an essential input into global, regional, and national health policies. In the Global Burden of Disease Study 201 ... Full text Link to item Cite

Recurrence After Partial Hepatectomy for Metastatic Colorectal Cancer: Potentially Curative Role of Salvage Repeat Resection.

Journal Article Ann Surg Oncol · August 2015 PURPOSE: Patients with recurrence after complete resection of colorectal liver metastases (CLM) are considered for repeat resection as a potential salvage therapy (PST). However, outcomes for this approach are not well defined. We sought to analyze the nat ... Full text Link to item Cite

Outcomes after Resection of Intrahepatic Cholangiocarcinoma: External Validation and Comparison of Prognostic Models.

Journal Article J Am Coll Surg · August 2015 BACKGROUND: Published prognostic models for overall survival after liver resection for intrahepatic cholangiocarcinoma require external validation before use in clinical practice. STUDY DESIGN: From January 1993 to May 2013, consecutive patients who underw ... Full text Link to item Cite

Goal-Directed Fluid Therapy Using Stroke Volume Variation for Resuscitation after Low Central Venous Pressure-Assisted Liver Resection: A Randomized Clinical Trial.

Journal Article J Am Coll Surg · August 2015 BACKGROUND: The optimal perioperative fluid resuscitation strategy for liver resections remains undefined. Goal-directed therapy (GDT) embodies a number of physiologic strategies to achieve an ideal fluid balance and avoid the consequences of over- or unde ... Full text Link to item Cite

Clinical implications of genomic alterations in the tumour and circulation of pancreatic cancer patients.

Journal Article Nat Commun · July 7, 2015 Pancreatic adenocarcinoma has the worst mortality of any solid cancer. In this study, to evaluate the clinical implications of genomic alterations in this tumour type, we perform whole-exome analyses of 24 tumours, targeted genomic analyses of 77 tumours, ... Full text Link to item Cite

Prospective evaluation of 18F-fluorodeoxyglucose positron emission tomography in patients receiving hepatic arterial and systemic chemotherapy for unresectable colorectal liver metastases.

Journal Article HPB (Oxford) · July 2015 BACKGROUND: The prognostic and predictive abilities of 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) coupled with conventional computed tomography (CT) have not been studied in patients with unresectable colorectal liver metastases (uCRLM ... Full text Link to item Cite

Simultaneous resection for rectal cancer with synchronous liver metastasis is a safe procedure.

Journal Article Am J Surg · June 2015 BACKGROUND: One quarter of colorectal cancer patients will present with liver metastasis at the time of diagnosis. Recent studies have shown that simultaneous resections are safe and feasible for stage IV colon cancer. Limited data are available for simult ... Full text Link to item Cite

GNAS and KRAS Mutations Define Separate Progression Pathways in Intraductal Papillary Mucinous Neoplasm-Associated Carcinoma.

Journal Article J Am Coll Surg · May 2015 BACKGROUND: Intraductal papillary mucinous neoplasms (IPMN) are being increasingly recognized as important precursors to pancreatic adenocarcinoma. Elucidation of the genetic changes underlying IPMN carcinogenesis may improve the diagnosis and management o ... Full text Link to item Cite

Surgical Management of IPMN Lesions of the Pancreas

Chapter · April 7, 2015 Segmental anatomic pancreatectomy with lymph node dissection is currently the most commonly reported technique for the operative management of intraductal papillary mucinous neoplasm (IPMN). More limited resection (enucleation or central pancreatectomy) ma ... Full text Cite

Hepatic parenchymal preservation surgery: decreasing morbidity and mortality rates in 4,152 resections for malignancy.

Conference J Am Coll Surg · April 2015 BACKGROUND: Liver resection is used to treat primary and secondary malignancies. Historically, these procedures were associated with significant complications, which may affect cancer-specific outcomes. This study analyzed the changes in morbidity and mort ... Full text Link to item Cite

Clinical features and outcome of primary pancreatic lymphoma.

Journal Article Ann Surg Oncol · April 2015 INTRODUCTION: Primary pancreatic lymphoma (PPL) is a rare tumor that is often misdiagnosed. Clinicopathologic features, optimal therapy, and outcomes are not well defined. We reviewed our institutional experience with PPL. METHODS: Search of our institutio ... Full text Link to item Cite

Chemotherapy-induced splenic volume increase is independently associated with major complications after hepatic resection for metastatic colorectal cancer.

Conference J Am Coll Surg · March 2015 BACKGROUND: In patients with colorectal cancer liver metastases (CRCLM), chemotherapy-induced hepatic injury is associated with increased splenic volume, thrombocytopenia, and decreased long-term survival. The current study investigates the relationship be ... Full text Link to item Cite

Texture analysis of preoperative CT images for prediction of postoperative hepatic insufficiency: a preliminary study.

Journal Article J Am Coll Surg · March 2015 BACKGROUND: Texture analysis is a promising method of analyzing imaging data to potentially enhance diagnostic capability. This approach involves automated measurement of pixel intensity variation that may offer further insight into disease progression tha ... Full text Link to item Cite

Renal function after low central venous pressure-assisted liver resection: assessment of 2116 cases.

Journal Article HPB (Oxford) · March 2015 OBJECTIVES: Low central venous pressure (LCVP)-assisted hepatectomy is associated with decreased blood loss and lower transfusion rates. Concerns about its impact on renal function have prevented widespread application. This study was conducted to review t ... Full text Link to item Cite

Premalignant cystic neoplasms of the pancreas.

Journal Article Semin Oncol · February 2015 Due to increasing utilization of cross-sectional imaging, asymptomatic pancreatic cysts are frequently being diagnosed. Many of these cysts have premalignant potential and offer a unique opportunity for cancer prevention. Mucinous cystic neoplasm and intra ... Full text Link to item Cite

Phase II trial of hepatic artery infusional and systemic chemotherapy for patients with unresectable hepatic metastases from colorectal cancer: conversion to resection and long-term outcomes.

Journal Article Ann Surg · February 2015 PURPOSE: Evaluate conversion rate of patients with unresectable colorectal-liver metastasis to complete resection with hepatic-arterial infusion plus systemic chemotherapy including bevacizumab (Bev). PATIENTS AND METHODS: Forty-nine patients with unresect ... Full text Link to item Cite

Hospital readmissions after liver surgery for metastatic colorectal cancer.

Journal Article Surgery · February 2015 BACKGROUND: Hospital readmission rates after surgery are increasingly used as a measure of quality of care. Numerous efforts to decrease these rates have been established by care providers and insurance companies. There is sparse information available rega ... Full text Link to item Cite

Definitive Characterization of CA 19-9 in Resectable Pancreatic Cancer Using a Reference Set of Serum and Plasma Specimens.

Journal Article PLoS One · 2015 The validation of candidate biomarkers often is hampered by the lack of a reliable means of assessing and comparing performance. We present here a reference set of serum and plasma samples to facilitate the validation of biomarkers for resectable pancreati ... Full text Link to item Cite

Cholangiocarcinoma: Correlation between Molecular Profiling and Imaging Phenotypes.

Journal Article PLoS One · 2015 PURPOSE: To investigate associations between imaging features of cholangiocarcinoma by visual assessment and texture analysis, which quantifies heterogeneity in tumor enhancement patterns, with molecular profiles based on hypoxia markers. METHODS: The inst ... Full text Link to item Cite

Long-term outcomes following microwave ablation for liver malignancies.

Journal Article Br J Surg · January 2015 BACKGROUND: Microwave ablation has emerged as a promising treatment for liver malignancies, but there are scant long-term follow-up data. This study evaluated long-term outcomes, with a comparison of 915-MHz and 2.4-GHz ablation systems. METHODS: This was ... Full text Link to item Cite

Distal pancreatectomy: a single institution's experience in open, laparoscopic, and robotic approaches.

Journal Article J Am Coll Surg · January 2015 BACKGROUND: The indications for minimally invasive (MIS) pancreatectomy have slowly increased as experience, techniques, and technology have improved and evolved to manage malignant lesions in selected patients without compromising safety and oncologic pri ... Full text Link to item Cite

KRAS mutation influences recurrence patterns in patients undergoing hepatic resection of colorectal metastases.

Journal Article Cancer · December 15, 2014 BACKGROUND: The validity of the KRAS mutation as a predictor of recurrence-free survival (RFS) or overall survival (OS) is unclear. The current study investigated whether the presence of the KRAS mutation decreased RFS or OS in patients with colorectal can ... Full text Link to item Cite

A retrospective comparison of microwave ablation vs. radiofrequency ablation for colorectal cancer hepatic metastases.

Journal Article Ann Surg Oncol · December 2014 BACKGROUND: Microwave (MWA) and radiofrequency ablation (RFA) are the most commonly used techniques for ablating colorectal-liver metastases (CRLM). The technical and oncologic differences between these modalities are unclear. METHODS: We conducted a match ... Full text Link to item Cite

Readmission after pancreatic resection: causes and causality pattern.

Journal Article Ann Surg Oncol · December 2014 BACKGROUND: Readmission rates have been targeted for cost/reimbursement control. Our goal was to identify causes for readmission and delineate the pattern of early and late readmission. METHODS: Between 2011 and 2012, a total of 490 patients underwent panc ... Full text Link to item Cite

American Joint Committee on Cancer staging for resected perihilar cholangiocarcinoma: a comparison of the 6th and 7th editions.

Conference HPB (Oxford) · December 2014 OBJECTIVES: This study was conducted to evaluate the prognostic value of, respectively, the 6th and 7th editions of the American Joint Committee on Cancer (AJCC) staging system for patients with resected perihilar cholangiocarcinoma (PHC). METHODS: Patient ... Full text Link to item Cite

Interobserver agreement for detection of malignant features of intraductal papillary mucinous neoplasms of the pancreas on MDCT.

Journal Article AJR Am J Roentgenol · November 2014 OBJECTIVE: The purpose of this retrospective study was to measure interobserver agreement in the assessment of malignant imaging features of intraductal papillary mucinous neoplasms (IPMNs) on MDCT. MATERIALS AND METHODS: Pancreatic protocol CT studies wer ... Full text Link to item Cite

Impact of pre-operative positron emission tomography in gallbladder cancer.

Journal Article HPB (Oxford) · November 2014 BACKGROUND: Current pre-operative staging methods for gallbladder cancer (GBC) are suboptimal in detecting metastatic disease. Positron emission tomography (PET) may have a role but data are lacking. METHODS: Patients with GBC and PET assessed by a hepatob ... Full text Link to item Cite

Predicting recurrence patterns after resection of hepatocellular cancer.

Journal Article HPB (Oxford) · October 2014 BACKGROUND: The reliable prediction of hepatocellular carcinoma (HCC) recurrence patterns potentially allows for the prioritization of patients for liver resection (LR) or transplantation. OBJECTIVES: The aim of this study was to analyse clinicopathologica ... Full text Link to item Cite

Remnant growth rate after portal vein embolization is a good early predictor of post-hepatectomy liver failure.

Journal Article J Am Coll Surg · October 2014 BACKGROUND: After portal vein embolization (PVE), the future liver remnant (FLR) hypertrophies for several weeks. An early marker that predicts a low risk of post-hepatectomy liver failure can reduce the delay to surgery. STUDY DESIGN: Liver volumes of 153 ... Full text Link to item Cite

Global, regional, and national levels and causes of maternal mortality during 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013.

Journal Article Lancet · September 13, 2014 BACKGROUND: The fifth Millennium Development Goal (MDG 5) established the goal of a 75% reduction in the maternal mortality ratio (MMR; number of maternal deaths per 100,000 livebirths) between 1990 and 2015. We aimed to measure levels and track trends in ... Full text Link to item Cite

Global, regional, and national incidence and mortality for HIV, tuberculosis, and malaria during 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013.

Journal Article Lancet · September 13, 2014 BACKGROUND: The Millennium Declaration in 2000 brought special global attention to HIV, tuberculosis, and malaria through the formulation of Millennium Development Goal (MDG) 6. The Global Burden of Disease 2013 study provides a consistent and comprehensiv ... Full text Link to item Cite

Mosaic partial deletion of the PTEN gene in a patient with Cowden syndrome.

Journal Article Fam Cancer · September 2014 Cowden syndrome is an autosomal dominant condition caused by pathogenic mutations in the phosphatase and tensin homolog (PTEN) gene. Only a small proportion of identified pathogenic mutations have been reported to be large deletions and rearrangements. We ... Full text Link to item Cite

Residual disease predicts outcomes after definitive resection for incidental gallbladder cancer.

Journal Article J Am Coll Surg · September 2014 BACKGROUND: Residual disease (RD) at definitive resection of incidental gallbladder cancer (IGBCA) influences outcome, but its clinical relevance with respect to anatomic site is incompletely characterized. STUDY DESIGN: Consecutive patients with IGBCA und ... Full text Link to item Cite

Pasireotide for postoperative pancreatic fistula.

Journal Article N Engl J Med · August 28, 2014 Full text Link to item Cite

Regional chemotherapy for unresectable intrahepatic cholangiocarcinoma: a potential role for dynamic magnetic resonance imaging as an imaging biomarker and a survival update from two prospective clinical trials.

Journal Article Ann Surg Oncol · August 2014 BACKGROUND: For patients with unresectable intrahepatic cholangiocarcinoma (ICC), treatment options are limited and survival is poor. This study summarizes the long-term outcome of two previously reported clinical trials using hepatic arterial infusion (HA ... Full text Link to item Cite

A single-arm, nonrandomized phase II trial of neoadjuvant gemcitabine and oxaliplatin in patients with resectable pancreas adenocarcinoma.

Journal Article Ann Surg · July 2014 BACKGROUND: The role for neoadjuvant systemic therapy in resectable pancreas adenocarcinoma remains undefined. OBJECTIVE: We evaluated the efficacy of gemcitabine and oxaliplatin administered as preoperative therapy in patients with resectable pancreas ade ... Full text Link to item Cite

Tumor MHC class I expression improves the prognostic value of T-cell density in resected colorectal liver metastases.

Journal Article Cancer Immunol Res · June 2014 Tumor-infiltrating lymphocytes (TIL) in colorectal cancer liver metastases (CLM) have been associated with more favorable patient outcomes, but whether MHC class I (MHC-I) expression on cancer cells affects prognosis is uncertain. Immunohistochemistry was ... Full text Link to item Cite

Pasireotide for postoperative pancreatic fistula.

Journal Article N Engl J Med · May 22, 2014 BACKGROUND: Postoperative pancreatic fistula is a major contributor to complications and death associated with pancreatic resection. Pasireotide, a somatostatin analogue that has a longer half-life than octreotide and a broader binding profile, decreases p ... Full text Link to item Cite

GFRα1 released by nerves enhances cancer cell perineural invasion through GDNF-RET signaling.

Journal Article Proc Natl Acad Sci U S A · May 13, 2014 The ability of cancer cells to invade along nerves is associated with aggressive disease and diminished patient survival rates. Perineural invasion (PNI) may be mediated by nerve secretion of glial cell line-derived neurotrophic factor (GDNF) attracting ca ... Full text Link to item Cite

Uncinate duct dilation in intraductal papillary mucinous neoplasms of the pancreas: a radiographic finding with potentially increased malignant potential.

Journal Article J Gastrointest Surg · May 2014 BACKGROUND: Risk of high-grade dysplasia and invasive carcinoma in intraductal papillary mucinous neoplasms (IPMN) of the pancreas is increased in main duct compared to branch duct lesions. We hypothesized that isolated uncinate duct dilation may also be a ... Full text Link to item Cite

Poorly differentiated neuroendocrine carcinomas of the pancreas: a clinicopathologic analysis of 44 cases.

Conference Am J Surg Pathol · April 2014 BACKGROUND: In the pancreas, poorly differentiated neuroendocrine carcinomas include small cell carcinoma and large cell neuroendocrine carcinoma and are rare; data regarding their pathologic and clinical features are very limited. DESIGN: A total of 107 p ... Full text Link to item Cite

Prognostic significance of the highest peripancreatic lymph node in biliary tract adenocarcinoma.

Journal Article Ann Surg Oncol · March 2014 BACKGROUND: Patients with biliary tract adenocarcinoma with nodal involvement have a poor prognosis. There is currently no standardized method for intraoperative lymph node assessment. The current study aimed to determine the prognostic significance of the ... Full text Link to item Cite

Treatment of extensive metastatic colorectal cancer to the liver with systemic and hepatic arterial infusion chemotherapy and two-stage hepatic resection: the role of salvage therapy for recurrent disease.

Journal Article Ann Surg Oncol · March 2014 BACKGROUND: Two-stage hepatectomy (TSH) has been adopted as a treatment modality for resection of advanced colorectal liver metastases (CRLM). This study analyzed the recurrence pattern, salvage rate, and survival after TSH combined with systemic and regio ... Full text Link to item Cite

Pathologic grade and tumor size are associated with recurrence-free survival in patients with duodenal neuroendocrine tumors.

Journal Article J Gastrointest Surg · March 2014 BACKGROUND: Duodenal neuroendocrine tumors are rare and few studies exist to guide surgical management. This study identifies factors associated with recurrence after resection. METHODS: A retrospective, single institution review was performed between 1983 ... Full text Link to item Cite

Timing of elective surgery as a perioperative outcome variable: analysis of pancreaticoduodenectomy.

Journal Article HPB (Oxford) · March 2014 OBJECTIVES: The timing of major elective operations is a potentially important but rarely examined outcome variable. This study examined elective pancreaticoduodenectomy (PD) timing as a perioperative outcome variable. METHODS: Consecutive patients submitt ... Full text Link to item Cite

Detection of circulating tumor DNA in early- and late-stage human malignancies.

Journal Article Sci Transl Med · February 19, 2014 The development of noninvasive methods to detect and monitor tumors continues to be a major challenge in oncology. We used digital polymerase chain reaction-based technologies to evaluate the ability of circulating tumor DNA (ctDNA) to detect tumors in 640 ... Full text Link to item Cite

Floxuridine hepatic arterial infusion associated biliary toxicity is increased by concurrent administration of systemic bevacizumab.

Journal Article Ann Surg Oncol · February 2014 PURPOSE: Systemic bevacizumab (Bev) was added to hepatic arterial infusion (HAI) floxuridine (FUDR)-based chemotherapy in three studies in an attempt to improve outcomes. A specific review of biliary toxicity was carried out. METHODS: This analysis include ... Full text Link to item Cite

Pharmacologic prophylaxis, postoperative INR, and risk of venous thromboembolism after hepatectomy.

Journal Article J Gastrointest Surg · February 2014 INTRODUCTION: Pharmacologic prophylaxis (PP) is recommended for patients undergoing general surgical procedures with at least moderate risk of venous thromboembolism (VTE). The role of PP in patients undergoing hepatectomy is controversial, however, due to ... Full text Link to item Cite

Combined ablation and resection (CARe) as an effective parenchymal sparing treatment for extensive colorectal liver metastases.

Journal Article PLoS One · 2014 BACKGROUND: Combined intra-operative ablation and resection (CARe) is proposed to treat extensive colorectal liver metastases (CLM). This multicenter study was conducted to evaluate overall survival (OS), local recurrence-free survival (LRFS), hepatic recu ... Full text Link to item Cite

Prediagnostic serum biomarkers as early detection tools for pancreatic cancer in a large prospective cohort study.

Journal Article PLoS One · 2014 BACKGROUND: The clinical management of pancreatic cancer is severely hampered by the absence of effective screening tools. METHODS: Sixty-seven biomarkers were evaluated in prediagnostic sera obtained from cases of pancreatic cancer enrolled in the Prostat ... Full text Link to item Cite

Endoscopic ultrasound-guided transmural drainage of postoperative pancreatic collections

Journal Article Journal of the American College of Surgeons · January 1, 2014 Background Pancreatic leak is a major cause of morbidity after pancreatectomy. Traditionally, peripancreatic fluid collections have been managed by percutaneous or operative drainage. Data for endoscopic ultrasound (EUS)-guided drainage of postoperative fl ... Full text Cite

Minimally-invasive vs open pancreaticoduodenectomy: Systematic review and meta-analysis

Journal Article Journal of the American College of Surgeons · January 1, 2014 Full text Cite

Pancreatic metastasectomy: the Memorial Sloan-Kettering experience and a review of the literature.

Journal Article J Surg Oncol · January 2014 Isolated pancreatic metastases may occur in patients with many types of cancer. Several retrospective case series have been published demonstrating the feasibility of resection in selected patients. Here we report our experience with pancreatic metastasect ... Full text Link to item Cite

Comparison between perioperative and postoperative chemotherapy after potentially curative hepatic resection for metastatic colorectal cancer.

Journal Article Ann Surg Oncol · December 2013 BACKGROUND: Additional chemotherapy in patients with resectable colorectal liver metastases (CRLM) likely improves outcomes. Whether to administer chemotherapy as perioperative or adjuvant therapy remains controversial. We analyzed outcomes between these t ... Full text Link to item Cite

Predicting dysplasia and invasive carcinoma in intraductal papillary mucinous neoplasms of the pancreas: development of a preoperative nomogram.

Journal Article Ann Surg Oncol · December 2013 BACKGROUND: Clinical decision making for patients with intraductal papillary mucinous neoplasms (IPMN) of the pancreas is challenging. Even with strict criteria for resection, most resected lesions lack high-grade dysplasia (HGD) or invasive carcinoma. MET ... Full text Link to item Cite

Chemotherapy after portal vein embolization to protect against tumor growth during liver hypertrophy before hepatectomy

Journal Article JAMA Surgery · December 1, 2013 IMPORTANCE Portal vein embolization improves the safety of liver resection by increasing the size of residual liver, but the embolization may increase tumor growth during the waiting period before definitive hepatectomy. OBJECTIVE To determine whether the ... Full text Cite

Operative drainage following pancreatic resection: analysis of 1122 patients resected over 5 years at a single institution.

Journal Article Ann Surg · December 2013 BACKGROUND: The only prospective randomized trial evaluating the use of intraperitoneal drainage following pancreatic resection was published from our institution approximately 10 years ago. The current study sought to evaluate the evolution of practice ov ... Full text Link to item Cite

Pancreas and liver resection in Jehovah's Witness patients: feasible and safe.

Journal Article J Am Coll Surg · December 2013 BACKGROUND: Jehovah's Witness (JW) patients undergoing liver or pancreas surgery represent a challenging ethical and medical problem, with few reports about their optimal management. STUDY DESIGN: To analyze the perioperative outcomes of JW patients submit ... Full text Link to item Cite

Specific glycoforms of MUC5AC and endorepellin accurately distinguish mucinous from nonmucinous pancreatic cysts.

Journal Article Mol Cell Proteomics · October 2013 Specific protein glycoforms may be uniquely informative about the pathological state of a cyst and may serve as accurate biomarkers. Here we tested that hypothesis using antibody-lectin sandwich arrays in broad screens of protein glycoforms and in targeted ... Full text Link to item Cite

Prognostic significance of early recurrence: a conditional survival analysis in patients with resected colorectal liver metastasis.

Journal Article HPB (Oxford) · October 2013 BACKGROUND: For patients undergoing liver resection for colorectal metastases, specific clinico-pathological variables have been shown to be prognostic at baseline. This study analyses how the prognostic capability of these variables changes in a condition ... Full text Link to item Cite

Dysplasia at the surgical margin is associated with recurrence after resection of non-invasive intraductal papillary mucinous neoplasms.

Journal Article HPB (Oxford) · October 2013 BACKGROUND: The significance of a positive margin in resected non-invasive pancreatic intraductal papillary mucinous neoplasms (IPMN) remains controversial. The aim of this study was to determine recurrence rates when dysplasia was present at the final sur ... Full text Link to item Cite

Incidentally discovered pancreatic intraepithelial neoplasia: what is its clinical significance?

Journal Article Ann Surg Oncol · October 2013 PURPOSE: Pancreatic intraepithelial neoplasia (PanIN) is a presumed precursor of pancreatic ductal adenocarcinoma (PDAC). We assessed the relationship between incidental PanIN after resection of non-adenocarcinoma lesions and the development of metachronou ... Full text Link to item Cite

Conversion to complete resection and/or ablation using hepatic artery infusional chemotherapy in patients with unresectable liver metastases from colorectal cancer: a decade of experience at a single institution.

Journal Article Ann Surg Oncol · September 2013 BACKGROUND: When feasible, surgical treatment of colorectal liver metastases (CRLM) is the treatment of choice. Regional hepatic artery infusional (HAI) chemotherapy effectively treats CRLM. The combination of HAI and systemic chemotherapy may downsize tum ... Full text Link to item Cite

c-MET and HGF mRNA expression in hepatocellular carcinoma: correlation with clinicopathological features and survival.

Journal Article Anticancer Res · August 2013 BACKGROUND/AIM: Data on the clinicopathological features and prognostic impact of c-N-Methyl-N'-nitro-N-nitroso-guanidine HOS Transforming gene (c-MET) and hepatocyte growth factor (HGF) in hepatocellular carcinoma (HCC) are inconsistent. We assessed c-MET ... Link to item Cite

Internal hernia after gastrectomy for cancer with Roux-Y reconstruction.

Journal Article Surgery · August 2013 BACKGROUND: The incidence of internal hernia (IH) after gastrectomy for cancer with Roux-Y reconstruction has not been well-defined. This study aimed to define the true incidence of IH after gastrectomy for cancer with Roux-Y reconstruction; to describe th ... Full text Link to item Cite

Failure patterns in resected pancreas adenocarcinoma: lack of predicted benefit to SMAD4 expression.

Journal Article Ann Surg · August 2013 OBJECTIVE: To determine whether SMAD4 expression is associated with recurrence pattern after resection for pancreatic ductal adenocarcinoma (PDA). BACKGROUND: SMAD4 expression status has been reported to be associated with patterns of failure in PDA, but s ... Full text Link to item Cite

Perioperative complications influence recurrence and survival after resection of hepatic colorectal metastases.

Journal Article Ann Surg Oncol · August 2013 BACKGROUND: Perioperative outcomes, such as blood loss, transfusions, and morbidity, have been linked to cancer-specific survival, but this is largely unsupported by prospective data. METHODS: Patients from a previous, randomized trial that evaluated acute ... Full text Link to item Cite

Long-term outcomes following tumor ablation for treatment of bilateral colorectal liver metastases.

Journal Article JAMA Surg · July 2013 IMPORTANCE: Ablative therapies extend the capability of delivering potentially curative treatment for bilateral hepatic colorectal metastases. OBJECTIVE: To compare the long-term effectiveness of ablation with that of resection in patients with bilateral h ... Full text Link to item Cite

Biliary self-expandable metal stents do not adversely affect pancreaticoduodenectomy.

Journal Article Am J Gastroenterol · July 2013 OBJECTIVES: Controversy exists regarding whether to place a plastic or a metal endobiliary stent in patients with resectable pancreatic cancer who require biliary drainage. Although self-expandable metal stents (SEMS) provide better drainage compared with ... Full text Link to item Cite

Gold nanoparticles provide bright long-lasting vascular contrast for CT imaging.

Journal Article AJR Am J Roentgenol · June 2013 OBJECTIVE: Iodinated contrast agent for CT has a short half-life in the vasculature. As the field of interventional procedures expands, a more durable contrast agent would be highly useful. Our study investigated whether gold nanoparticles are feasible as ... Full text Link to item Cite

Risk of occult irresectable disease at liver resection for hepatic colorectal cancer metastases: a contemporary analysis.

Journal Article Ann Surg Oncol · June 2013 INTRODUCTION: Traditionally, rates of irresectable disease at laparotomy for colorectal liver metastases (CRLM) have ranged from 15 to 70%. Diagnostic laparoscopy has been shown to be effective at preventing nontherapeutic laparotomy in selected patients. ... Full text Link to item Cite

Hepatic arterial nodal metastases in pancreatic cancer: is this the node of importance?

Journal Article J Gastrointest Surg · June 2013 BACKGROUND: The hepatic artery lymph node (HALN) is frequently sampled during pancreaticoduodenectomy (PD). Data suggest that survival in the setting of HALN metastases is similar to that of stage IV pancreatic ductal adenocarcinoma (PDAC). The objectives ... Full text Link to item Cite

Vascular inflow control during hemi-hepatectomy: a comparison between intrahepatic pedicle ligation and extrahepatic vascular ligation.

Journal Article HPB (Oxford) · June 2013 BACKGROUND: Intrahepatic pedicle ligation (IPL) is an alternative to extrahepatic portal dissection (EPD). Although IPL has been well described, concern has arisen over a possible association with increased complication rates. METHODS: Patients who underwe ... Full text Link to item Cite

Intraoperative fluid management and complications following pancreatectomy.

Journal Article J Surg Oncol · April 2013 BACKGROUND: Considerable debate exists as to appropriate perioperative fluid management. Data from several studies suggest that the amount of fluid administered perioperatively influences surgical outcome. Pancreatic resection is a major procedure in which ... Full text Link to item Cite

Management of hepatocellular adenoma: comparison of resection, embolization and observation.

Journal Article HPB (Oxford) · March 2013 INTRODUCTION: Hepatocellular adenoma (HA) is an uncommon benign hepatic tumour with the potential for malignant change or spontaneous haemorrhage. Resection has been the recommended treatment, but outcomes with other approaches are ill defined. METHODS: De ... Full text Link to item Cite

Malignant progression in IPMN: a cohort analysis of patients initially selected for resection or observation.

Journal Article Ann Surg Oncol · February 2013 BACKGROUND: Intraductal papillary mucinous neoplasms (IPMN) may represent a field defect of pancreatic ductal instability. The relative risk of carcinoma in regions remote from the radiographically identified cyst remains poorly defined. This study describ ... Full text Link to item Cite

Changes in the management of benign liver tumours: an analysis of 285 patients.

Journal Article HPB (Oxford) · February 2013 OBJECTIVES: Benign liver tumours (BLTs) are common and their management remains controversial. This study assesses the safety of a selective management approach. METHODS: Patients with BLT were identified from an institutional database. Patients with simpl ... Full text Link to item Cite

Gene expression profiles accurately predict outcome following liver resection in patients with metastatic colorectal cancer.

Journal Article PLoS One · 2013 PURPOSE: The aim of this study was to build a molecular prognostic model based on gene signatures for patients with completely resected hepatic metastases from colorectal cancer (MCRC). METHODS: Using the Illumina HumanHT-12 gene chip, RNA samples from the ... Full text Link to item Cite

Management of peripancreatic fluid collections following partial pancreatectomy: A comparison of percutaneous versus EUS-guided drainage

Journal Article Surgical Endoscopy · January 1, 2013 Background: Peripancreatic fluid collections (PFCs) occur in up to 30 % of patients following partial pancreatic resections. Traditionally, postoperative PFCs are managed via percutaneous drainage (PD). EUS-guided transgastric drainage has been shown to be ... Full text Cite

Does pre-operative chemoradiation for initially unresectable or borderline resectable pancreatic adenocarcinoma increase post-operative morbidity? A case-matched analysis

Conference HPB · January 1, 2013 Background Neoadjuvant chemoradiation therapy for locally unresectable and borderline resectable pancreatic cancer may allow some patients to a undergo a resection, but whether or not this increases post-operative morbidity remains unclear. Methods The pos ... Full text Cite

Detailed pathologic characteristics of the primary colorectal tumor independently predict outcome after hepatectomy for metastases.

Journal Article Ann Surg Oncol · January 2013 INTRODUCTION: Outcome after hepatic resection for colorectal cancer liver metastases (CRLM) is heterogeneous and accurate predictors of survival are lacking. This study analyzes the prognostic relevance of pathologic details of the primary colorectal tumor ... Full text Link to item Cite

Hepatic pedicle clamping during hepatic resection for colorectal liver metastases: no impact on survival or hepatic recurrence.

Journal Article Ann Surg Oncol · January 2013 BACKGROUND: Hepatic pedicle clamping is often used during liver resection. While its use reduces blood loss and transfusion requirements, the long-term effect on survival and recurrence has been debated. This study evaluates the effect of hepatic pedicle c ... Full text Link to item Cite

Preoperative chemotherapy and the risk of hepatotoxicity and morbidity after liver resection for metastatic colorectal cancer: a single institution experience.

Journal Article J Am Coll Surg · January 2013 BACKGROUND: Patients undergoing liver resection for colorectal cancer liver metastasis (CRCLM) are often treated with chemotherapy before surgery. However, the associations between chemotherapy, liver injury, perioperative outcomes, and other confounding f ... Full text Link to item Cite

Synchronous resection of primary and liver metastases for neuroendocrine tumors.

Journal Article Ann Surg Oncol · December 2012 BACKGROUND: Surgical approach is an accepted approach for metastatic neuroendocrine tumors (NET), but the safety and effectiveness of synchronous liver metastases resection with primary and/or locally recurrent NET is unclear. METHODS: From 1992 to 2009, a ... Full text Link to item Cite

Hepatic artery infusional chemotherapy in patients with unresectable colorectal liver metastases and extrahepatic disease.

Journal Article J Surg Oncol · December 2012 BACKGROUND AND OBJECTIVES: Hepatic arterial infusional (HAI) chemotherapy combined with systemic chemotherapy is effective palliative therapy for unresectable colorectal cancer liver metastases (CRLM). Some patients considered for HAI have evidence of mini ... Full text Link to item Cite

Patterns of failure in patients with early onset (synchronous) resectable liver metastases from rectal cancer.

Journal Article Cancer · November 1, 2012 BACKGROUND: The optimal combination of available therapies for patients with resectable synchronous liver metastases from rectal cancer (SLMRC) is unknown, and the pattern of recurrence after resection has been poorly investigated. In this study, the autho ... Full text Link to item Cite

Contemporary experience with postpancreatectomy hemorrhage: results of 1,122 patients resected between 2006 and 2011.

Journal Article J Am Coll Surg · November 2012 BACKGROUND: Postpancreatectomy hemorrhage (PPH) is a life-threatening complication of pancreatic resection. Most published series span decades and do not reflect contemporary practice. This study analyzes the rate, management, and outcomes of PPH during a ... Full text Link to item Cite

Distal pancreatectomy-open

Chapter · October 31, 2012 Cite

Intraductal papillary neoplasm of the bile duct: a biliary equivalent to intraductal papillary mucinous neoplasm of the pancreas?

Journal Article Hepatology · October 2012 UNLABELLED: Intraductal papillary neoplasm of the bile duct (IPNB) is a variant of bile duct carcinoma characterized by intraductal growth and better outcome compared with the more common nodular-sclerosing type. IPNB is a recognized precursor of invasive ... Full text Link to item Cite

Neoadjuvant therapy in clinical stage II pancreatic adenocarcinoma

Journal Article Gastrointestinal Cancer Research · September 1, 2012 Cite

Impact of obesity and body fat distribution on survival after pancreaticoduodenectomy for pancreatic adenocarcinoma.

Journal Article Ann Surg Oncol · September 2012 BACKGROUND: Epidemiologic studies have reported a positive correlation between body mass index (BMI) and pancreatic cancer risk, but clinical relevance of obesity and/or body fat distribution on tumor characteristics and cancer-related outcome remain contr ... Full text Link to item Cite

Pathologic response to preoperative chemotherapy in colorectal liver metastases: fibrosis, not necrosis, predicts outcome.

Journal Article Ann Surg Oncol · September 2012 BACKGROUND: Pathologic response to preoperative chemotherapy for colorectal liver metastases (CLM) is associated with survival after hepatectomy. Histologically, dominant response patterns include fibrosis, necrosis and/or acellular mucin, but some of thes ... Full text Link to item Cite

Attenuation of the retinoblastoma pathway in pancreatic neuroendocrine tumors due to increased cdk4/cdk6.

Journal Article Clin Cancer Res · September 1, 2012 PURPOSE: In mice, genetic changes that inactivate the retinoblastoma tumor suppressor pathway often result in pancreatic neuroendocrine tumors (Pan-NETs). Conversely, in humans with this disease, mutations in genes of the retinoblastoma pathway have rarely ... Full text Link to item Cite

Invited commentary.

Journal Article J Am Coll Surg · September 2012 Full text Link to item Cite

Ablation of perivascular hepatic malignant tumors with irreversible electroporation.

Journal Article J Am Coll Surg · September 2012 BACKGROUND: Ablation is increasingly used to treat primary and secondary liver cancer. Ablation near portal pedicles and hepatic veins is challenging. Irreversible electroporation (IRE) is a new ablation technique that does not rely on heat and, in animals ... Full text Link to item Cite

The Blumgart preoperative staging system for hilar cholangiocarcinoma: analysis of resectability and outcomes in 380 patients.

Journal Article J Am Coll Surg · September 2012 BACKGROUND: Complete resection of hilar cholangiocarcinoma (HCCA) is a critical determinant of long-term survival. This study validates a previously reported preoperative clinical T staging system for determining resectability of HCCA. STUDY DESIGN: Consec ... Full text Link to item Cite

Resection of adrenocortical carcinoma liver metastasis: is it justified?

Journal Article Ann Surg Oncol · August 2012 BACKGROUND: Adrenocortical carcinoma (ACC) liver metastases (LM) represent a therapeutic challenge, and it is unclear whether resection is justified. This study assesses long-term outcome and prognostic factors after liver resection for metastatic ACC. MET ... Full text Link to item Cite

CXCR4 expression predicts patient outcome and recurrence patterns after hepatic resection for colorectal liver metastases.

Journal Article Ann Surg Oncol · July 2012 BACKGROUND: The purpose of this study was to determine if the expression of the chemokine receptors, CXCR4 and CCR7, and the chemokine ligand, CXCL12, in completely resected colorectal cancer hepatic metastases are predictive of disease-specific survival, ... Full text Link to item Cite

Recurrence after complete resection and selective use of adjuvant therapy for stage I through III Merkel cell carcinoma.

Journal Article Cancer · July 1, 2012 BACKGROUND: Merkel cell carcinoma (MCC) is a rare cutaneous neuroendocrine neoplasm whose natural history is poorly understood. Here, the authors describe their experience with a large cohort of patients who were treated at a single institution to describe ... Full text Link to item Cite

Comparison of surgical and endoscopic sample collection for pancreatic cyst fluid biomarker identification.

Journal Article J Proteome Res · May 4, 2012 Significant efforts are underway to develop new biomarkers from pancreatic cyst fluid. Previous research has made use of cyst fluid collected from surgically removed cysts, but the clinical implementation of biomarkers would use cyst fluid collected by end ... Full text Link to item Cite

Rt-PCR increases detection of submicroscopic peritoneal metastases in gastric cancer and has prognostic significance.

Journal Article J Gastrointest Surg · May 2012 BACKGROUND: Positive peritoneal cytology confers the same prognosis as clinical stage IV disease in gastric cancer. Conventional cytology examination, however, has low sensitivity. We hypothesize that real-time polymerase chain reaction (RT-PCR) may have i ... Full text Link to item Cite

Downstaging in pancreatic cancer: a matched analysis of patients resected following systemic treatment of initially locally unresectable disease.

Journal Article Ann Surg Oncol · May 2012 BACKGROUND: Patients with locally unresectable pancreatic cancer (AJCC stage III) have a median survival of 10-14 months. The objective of this study was to evaluate outcome of initially unresectable patients who respond to multimodality therapy and underg ... Full text Link to item Cite

Biliary sclerosis after hepatic arterial infusion pump chemotherapy for patients with colorectal cancer liver metastasis: incidence, clinical features, and risk factors.

Journal Article Ann Surg Oncol · May 2012 BACKGROUND: Hepatic arterial infusion pump chemotherapy (HAIPC) contributes to the prolonged survival of selected patients with colorectal cancer liver metastases (CRCLM). The most clinically important adverse event after HAIPC with floxuridine (FUDR) is b ... Full text Link to item Cite

The outcome of resected cystic pancreatic endocrine neoplasms: a case-matched analysis.

Journal Article Surgery · April 2012 INTRODUCTION: Cystic pancreatic endocrine neoplasms (CPENs) are uncommon tumors with uncertain disease biology and ill-defined diagnostic features. METHODS: A prospectively maintained pancreatic cyst registry was queried, and 31 cases of CPEN that were res ... Full text Link to item Cite

Patterns of recurrence after ablation of colorectal cancer liver metastases.

Journal Article Ann Surg Oncol · March 2012 PURPOSE: To determine the local recurrence rate and factors associated with recurrence after intraoperative ablation of colorectal cancer liver metastases. METHODS: A retrospective analysis of a prospectively maintained database was performed for patients ... Full text Link to item Cite

Improving the clinical risk score: an analysis of molecular biomarkers in the era of modern chemotherapy for resectable hepatic colorectal cancer metastases.

Journal Article Surgery · February 2012 BACKGROUND: The prognostic relevance of variations in expression of specific tumor genes in colorectal cancer liver metastases (CRCLMs) in patients treated with resection and modern chemotherapy is not known. METHODS: Patients submitted to liver resection ... Full text Link to item Cite

Is port site resection necessary in the surgical management of gallbladder cancer?

Journal Article Ann Surg Oncol · February 2012 BACKGROUND: In selected patients with incidental gallbladder carcinoma (GBCA) diagnosed after laparoscopic cholecystectomy (LC), definitive resection is warranted. Port site excision has been advocated but remains controversial. METHODS: Patients with GBCA ... Full text Link to item Cite

A novel survival-based tissue microarray of pancreatic cancer validates MUC1 and mesothelin as biomarkers.

Journal Article PLoS One · 2012 BACKGROUND: One-fifth of patients with seemingly 'curable' pancreatic ductal adenocarcinoma (PDA) experience an early recurrence and death, receiving no definable benefit from a major operation. Some patients with advanced stage tumors are deemed 'unresect ... Full text Link to item Cite

Operative procedures for unresectable pancreatic cancer: Does operative bypass decrease requirements for postoperative procedures and in-hospital days?

Journal Article HPB · January 1, 2012 Background: The optimal surgical management of patients found to have unresectable pancreatic cancer at open exploration remains unknown. Methods: Records of patients who underwent non-therapeutic laparotomy for pancreatic cancer during 2000-2009 and were ... Full text Cite

Survival after resection of pancreatic adenocarcinoma: results from a single institution over three decades.

Journal Article Ann Surg Oncol · January 2012 BACKGROUND: Randomized trials have demonstrated a benefit associated with adjuvant therapy for pancreatic cancer, and retrospective studies have demonstrated improvements in postoperative mortality. The purpose of this study was to evaluate whether these i ... Full text Link to item Cite

Whole-exome sequencing of neoplastic cysts of the pancreas reveals recurrent mutations in components of ubiquitin-dependent pathways.

Journal Article Proc Natl Acad Sci U S A · December 27, 2011 More than 2% of adults harbor a pancreatic cyst, a subset of which progresses to invasive lesions with lethal consequences. To assess the genomic landscapes of neoplastic cysts of the pancreas, we determined the exomic sequences of DNA from the neoplastic ... Full text Link to item Cite

Comparison of adjuvant systemic chemotherapy with or without hepatic arterial infusional chemotherapy after hepatic resection for metastatic colorectal cancer.

Journal Article Ann Surg · December 2011 BACKGROUND: The potential benefit of adjuvant hepatic arterial infusional floxuridine (HAI-FUDR) in addition to modern systemic chemotherapy using oxaliplatin or irinotecan remains unknown for patients with resected liver-confined colorectal metastases (CR ... Full text Link to item Cite

High-grade dysplasia of the cystic duct margin in the absence of malignancy after cholecystectomy.

Journal Article HPB (Oxford) · December 2011 BACKGROUND: A total of 750,000 cholecystectomies are performed annually in the USA. No data exist on patients with microscopic high-grade dysplasia at the cystic duct margin and the associated incidence of cholangiocarcinoma. METHODS: Pathology reports for ... Full text Link to item Cite

Resection of perihilar biliary schwannoma.

Journal Article Surg Oncol · December 2011 INTRODUCTION: Schwannomas are usually benign nerve sheath tumors, which typically arise in the head, neck, spinal cord and extremities. Schwannoma of the biliary tract is an extremely rare finding. Patients generally lack symptoms and seek medical attentio ... Full text Link to item Cite

Pitfalls in avoiding operation for autoimmune pancreatitis.

Journal Article Surgery · November 2011 BACKGROUND: Despite improved clinical characterization, autoimmune pancreatitis is often still diagnosed only after a major operative procedure. This study seeks to elucidate the circumstances that contribute to an inaccurate preoperative diagnosis. METHOD ... Full text Link to item Cite

Folate receptor-α expression in resectable hepatic colorectal cancer metastases: patterns and significance.

Journal Article Mod Pathol · September 2011 Folate receptor alpha (FRα), encoded by folate receptor 1 (adult) gene, has emerged as a cancer biomarker and potential therapeutic target. In addition, its expression in tumors may offer prognostic information. The aim of this study was to assess the prog ... Full text Link to item Cite

Liver angiomyolipomas: a clinical, radiologic, and pathologic analysis of 22 patients from a single center.

Journal Article Surgery · September 2011 BACKGROUND: Liver angiomyolipomas (AML) are mesenchymal neoplasms with an uncertain clinical behavior. The spectrum of presentation, imaging and histologic features, and outcomes were analyzed in all patients treated at Memorial Sloan-Kettering Cancer Cent ... Full text Link to item Cite

Five hundred patients with Merkel cell carcinoma evaluated at a single institution.

Conference Ann Surg · September 2011 OBJECTIVE: To identify factors associated with survival in Merkel cell carcinoma (MCC). BACKGROUND: Merkel cell carcinoma is a rare cutaneous neoplasm. Staging and treatment are based on studies, which incompletely characterize the disease. METHODS: Review ... Full text Link to item Cite

Accurate staging for gallbladder cancer: implications for surgical therapy and pathological assessment.

Journal Article Ann Surg · August 2011 BACKGROUND: This study evaluates the significance of tumor involvement of the liver in early T-stage tumors and lymph node (LN) metastases on outcome after R0 resection of gallbladder cancer (GBCA). METHODS: A prospectively maintained database, supplemente ... Full text Link to item Cite

Antiangiogenic therapy for primary liver cancer: correlation of changes in dynamic contrast-enhanced magnetic resonance imaging with tissue hypoxia markers and clinical response.

Journal Article Ann Surg Oncol · August 2011 BACKGROUND: This study utilized the imaging data of primary liver cancer (PLC) treated with floxuridine (FUDR) and bevacizumab to test the hypothesis that dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) parameters correlate with tissue hypox ... Full text Link to item Cite

Recurrent GNAS mutations define an unexpected pathway for pancreatic cyst development.

Journal Article Sci Transl Med · July 20, 2011 More than 2% of the adult U.S. population harbors a pancreatic cyst. These often pose a difficult management problem because conventional criteria cannot always distinguish cysts with malignant potential from those that are innocuous. One of the most commo ... Full text Link to item Cite

Use of intraoperative ablation as an adjunct to surgical resection in the treatment of recurrent colorectal liver metastases.

Journal Article J Gastrointest Surg · July 2011 OBJECTIVE: To evaluate the role of intraoperative ablation as an adjunct to resection in patients with recurrent colorectal liver metastases (rCLM). METHODS: All patients undergoing curative-intent reoperative surgery for rCLM from 1992 to 2009 at a tertia ... Full text Link to item Cite

Studying cancer in minorities: a look at the numbers.

Journal Article Cancer · June 15, 2011 BACKGROUND: Inclusion of minorities is an important but challenging aspect of epidemiologic studies in the United States. One aspect of this challenge that has received little attention is the actual number of minorities with specific cancers. The authors ... Full text Link to item Cite

Single-incision laparoscopic liver resection.

Journal Article Surg Endosc · May 2011 BACKGROUND: Laparoscopic liver surgery has become a safe and effective approach to the surgical management of liver disease. Recently developed, single-port-access surgery is of growing interest in an attempt to minimize abdominal wall trauma. Various abdo ... Full text Link to item Cite

Invasive carcinoma arising in intraductal papillary mucinous neoplasms of the pancreas: a matched control study with conventional pancreatic ductal adenocarcinoma.

Journal Article Ann Surg · May 2011 OBJECTIVE: The purpose of this study was to characterize the clinicopathological features of invasive carcinomas arising in intraductal papillary mucinous neoplasms of the pancreas (IPMN) by histological subtype of the invasive component and to compare the ... Full text Link to item Cite

Feasibility and yield of screening in relatives from familial pancreatic cancer families.

Journal Article Am J Gastroenterol · May 2011 OBJECTIVES: Pancreatic adenocarcinoma is a lethal disease. Over 80% of patients are found to have metastatic disease at the time of diagnosis. Strategies to improve disease-specific outcome include identification and early detection of precursor lesions or ... Full text Link to item Cite

Cystic lesions of the pancreas: changes in the presentation and management of 1,424 patients at a single institution over a 15-year time period.

Journal Article J Am Coll Surg · April 2011 BACKGROUND: Cystic lesions of the pancreas are being identified more frequently, and a selective approach to resection is now recommended. The aim of this study was to assess the change in presentation and management of pancreatic cystic lesions evaluated ... Full text Link to item Cite

Discussion

Journal Article Journal of the American College of Surgeons · April 1, 2011 Full text Cite

Cyst fluid interleukin-1beta (IL1beta) levels predict the risk of carcinoma in intraductal papillary mucinous neoplasms of the pancreas.

Journal Article Clin Cancer Res · March 15, 2011 PURPOSE: Biomarkers for high-grade dysplasia in patients with radiographically identified intraductal papillary mucinous neoplasms (IPMN) have not been described. We hypothesized that dysplasia in IPMN invokes an immunogenic/proinflammatory microenvironmen ... Full text Link to item Cite

Prospective evaluation of laparoscopic celiac plexus block in patients with unresectable pancreatic adenocarcinoma.

Journal Article Ann Surg Oncol · March 2011 INTRODUCTION: The efficacy of laparoscopic celiac plexus block (CPB) in patients with unresectable pancreatic cancer has not been reported. METHODS: Patients with elevated pain scores scheduled for laparoscopy for diagnosis/staging of unresectable pancreat ... Full text Link to item Cite

Reply

Journal Article Journal of the American College of Surgeons · March 1, 2011 Full text Cite

Serum biomarker panels for the detection of pancreatic cancer.

Journal Article Clin Cancer Res · February 15, 2011 PURPOSE: Serum-biomarker based screening for pancreatic cancer could greatly improve survival in appropriately targeted high-risk populations. EXPERIMENTAL DESIGN: Eighty-three circulating proteins were analyzed in sera of patients diagnosed with pancreati ... Full text Link to item Cite

Solid pseudopapillary tumors of the pancreas. Clinical features, surgical outcomes, and long-term survival in 45 consecutive patients from a single center.

Journal Article J Gastrointest Surg · February 2011 BACKGROUND: Solid pseudopapillary tumors of the pancreas (SPT) are rare neoplasms, and the natural history is poorly defined. The aim of this study was to define the natural history and compare patient and tumor factors between patients with malignant and ... Full text Link to item Cite

Acinar cell carcinoma of the pancreas: new genetic and treatment insights into a rare malignancy.

Journal Article Oncologist · 2011 BACKGROUND: Acinar cell carcinoma (ACC) of the pancreas is a rare neoplasm, accounting for 1% of all pancreatic neoplasms. There remains a lack of data regarding the use of systemic therapy in this disease. We present a series of 40 consecutive cases of AC ... Full text Link to item Cite

An emerging entity: pancreatic adenocarcinoma associated with a known BRCA mutation: clinical descriptors, treatment implications, and future directions.

Journal Article Oncologist · 2011 BACKGROUND: BRCA1 and BRCA2 germline mutations are associated with an elevated risk for pancreas adenocarcinoma (PAC). Other BRCA-associated cancers have been shown to have greater sensitivity to platinum and poly(ADP-ribose) polymerase (PARP) inhibitors w ... Full text Link to item Cite

Treating primary liver cancer with hepatic arterial infusion of floxuridine and dexamethasone: does the addition of systemic bevacizumab improve results?

Journal Article Oncology · 2011 OBJECTIVES: This study investigated the efficacy and safety of adding systemic (IV) bevacizumab (Bev) to hepatic arterial infusion (HAI) with floxuridine (FUDR)/dexamethasone (Dex) in unresectable primary liver cancer. METHODS: Patients with unresectable i ... Full text Link to item Cite

Synchronous epithelial and neuroendocrine cancers of the pancreas: Case series of a rare occurrence

Journal Article Clinical Colorectal Cancer · January 1, 2011 The presence of neuroendocrine cells in adenocarcinomas is not an unusual finding and is well described in gastrointestinal tract cancers, eg, colorectal cancer and gastric cancer. Genetic analysis of such tumors has suggested a common multipotent progenit ... Full text Cite

Pancreatic cyst fluid and serum mucin levels predict dysplasia in intraductal papillary mucinous neoplasms of the pancreas.

Journal Article Ann Surg Oncol · January 2011 INTRODUCTION: There are no reliable markers of dysplasia in patients with incidentally discovered intraductal papillary mucinous neoplasms of the pancreas (IPMN). IPMN dysplasia may be associated with mucin protein (MUC) expression and histopathologic subt ... Full text Link to item Cite

The role of laparoscopic staging in patients with incidental gallbladder cancer

Journal Article HPB · January 1, 2011 Background: The role of staging laparoscopy (SL) in patients with incidental gallbladder cancer (IGBC) is ill defined. This study evaluates the utility of SL with the aim of identifying variables associated with disseminated disease (DD). Methods: Consecut ... Full text Cite

Gallbladder cancer: differences in presentation, surgical treatment, and survival in patients treated at centers in three countries.

Journal Article J Am Coll Surg · January 2011 BACKGROUND: Gallbladder cancer (GBCA) is a rare malignancy with a variable incidence worldwide. This study analyzed GBCA patients treated at centers in 3 countries. The aim was to assess for location-specific differences in presentation and outcomes, which ... Full text Link to item Cite

Evaluation of cyst fluid CEA analysis in the diagnosis of mucinous cysts of the pancreas.

Journal Article J Gastrointest Surg · December 2010 BACKGROUND: Although cyst fluid carcinoembryonic antigen (CEA; > 192 ng/ml) is the preferred test for identifying mucinous pancreatic cysts, the data are more robust for mucinous cystic neoplasms (MCN) than for intraductal papillary mucinous neoplasms (IPM ... Full text Link to item Cite

Gene amplifications in well-differentiated pancreatic neuroendocrine Tumors inactivate the p53 Pathway

Journal Article Genes and Cancer · December 1, 2010 Neuroendocrine tumors (NETs) comprise a group of rare tumors derived from the diffuse neuroendocrine system or islet endocrine cells of the pancreas. The molecular mechanisms underlying NETs are largely unknown. The tumor suppressor p53 plays a critical ro ... Full text Cite

Relationship between intraoperative fluid administration and perioperative outcome after pancreaticoduodenectomy: results of a prospective randomized trial of acute normovolemic hemodilution compared with standard intraoperative management.

Journal Article Ann Surg · December 2010 BACKGROUND: Pancreaticoduodenectomy (PD) can be associated with significant blood loss and transfusion requirements, with potential adverse short- and long-term consequences. The aim of this study was to determine whether acute normovolemic hemodilution (A ... Full text Link to item Cite

Cystic tumors of the pancreas

Chapter · November 23, 2010 Cite

Allergies, obesity, other risk factors and survival from pancreatic cancer.

Journal Article Int J Cancer · November 15, 2010 Survival from pancreatic adenocarcinoma remains extremely poor, approximately 5% at 5 years. Risk factors include smoking, high body mass index (BMI), family history of pancreatic cancer, and long-standing diabetes; in contrast, allergies are associated wi ... Full text Link to item Cite

Laparoscopic distal pancreatectomy: evolution of a technique at a single institution.

Journal Article J Am Coll Surg · October 2010 BACKGROUND: The pancreas remains an organ for which routine laparoscopic resection is uncommon. STUDY DESIGN: This is a review of all distal pancreatectomies performed between January 2003 and December 2009 at Memorial Sloan-Kettering Cancer Center. Variab ... Full text Link to item Cite

Electronic synoptic operative reporting: assessing the reliability and completeness of synoptic reports for pancreatic resection.

Journal Article J Am Coll Surg · September 2010 BACKGROUND: Electronic synoptic operative reports (E-SORs) have replaced dictated reports at many institutions, but whether E-SORs adequately document the components and findings of an operation has received limited study. This study assessed the reliabili ... Full text Link to item Cite

Biobanking of human pancreas cancer tissue: impact of ex-vivo procurement times on RNA quality.

Journal Article Ann Surg Oncol · August 2010 BACKGROUND: Tissue banking has become a major initiative at many oncology centers. The influence of warm ex-vivo ischemia times, storage times, and biobanking protocols on RNA integrity and subsequent microarray data is not well documented. METHODS: A pros ... Full text Link to item Cite

Resolution of hepatic encephalopathy following hepatic artery embolization in a patient with well-differentiated neuroendocrine tumor metastatic to the liver.

Journal Article Cardiovasc Intervent Radiol · June 2010 Hepatic encephalopathy is considered a contraindication to hepatic artery embolization. We describe a patient with a well-differentiated neuroendocrine tumor metastatic to the liver with refractory hepatic encephalopathy and normal liver function tests. Th ... Full text Link to item Cite

Survival after hepatic resection for metastatic colorectal cancer: trends in outcomes for 1,600 patients during two decades at a single institution.

Journal Article J Am Coll Surg · May 2010 BACKGROUND: This study analyzes factors associated with differences in long-term outcomes after hepatic resection for metastatic colorectal cancer over time. STUDY DESIGN: Sixteen-hundred consecutive patients undergoing hepatic resection for metastatic col ... Full text Link to item Cite

Adequate lymph node assessment for extrahepatic bile duct adenocarcinoma.

Journal Article Ann Surg · April 2010 OBJECTIVE: To examine the importance of adequate lymph node sampling in staging of extrahepatic bile duct cancer (EHBDCA). SUMMARY OF BACKGROUND DATA: The American Joint Committee on Cancer staging manual (sixth edition) states that histologic examination ... Full text Link to item Cite

The management of intraductal papillary mucinous neoplasms of the pancreas.

Journal Article Surg Oncol Clin N Am · April 2010 Intraductal papillary mucinous neoplasms (IPMN) are mucinous cystic tumors of the pancreas, which were first classified into a unified diagnosis by the World Health Organization in 1996. These lesions originate from the cells of the pancreatic ductal syste ... Full text Link to item Cite

Kinetics of liver volume changes in the first year after portal vein embolization.

Journal Article Arch Surg · April 2010 OBJECTIVE: To determine the time course of liver hypertrophy after portal vein embolization (PVE). DESIGN: In a cohort study, computed tomography volumetrics were calculated for livers during a 1-year period after PVE. SETTING: Tertiary liver cancer treatm ... Full text Link to item Cite

Synthesis, characterization, and functionalization of gold nanoparticles for cancer imaging.

Journal Article Methods Mol Biol · 2010 This chapter describes the methodology by which mAb-F19-conjugated gold nanoparticles were prepared and used to label human pancreatic adenocarcinoma. Specifically, gold nanoparticles were coated with dithiol bearing hetero-bifunctional PEG (polyethylene g ... Full text Link to item Cite

T cell infiltrate and outcome following resection of intermediate-grade primary neuroendocrine tumours and liver metastases

Journal Article HPB · January 1, 2010 Background: Tumour-infiltrating lymphocytes (TILs) have been shown to predict survival in numerous malignancies. The importance of TILs in primary pancreatic neuroendocrine tumours (NETs) and NET liver metastases (NETLMs) has not been defined. Methods: We ... Full text Cite

Natural history of patients with subcentimeter pulmonary nodules undergoing hepatic resection for metastatic colorectal cancer.

Journal Article J Am Coll Surg · January 2010 BACKGROUND: CT imaging frequently detects subcentimeter pulmonary nodules (SPN) in patients undergoing resection of colorectal cancer liver metastases. Their clinical significance is unknown. STUDY DESIGN: Patients were identified who underwent hepatic res ... Full text Link to item Cite

Randomized clinical trials in pancreatic adenocarcinoma.

Journal Article Surg Oncol Clin N Am · January 2010 This article critically reviews and ranks 107 prospective, randomized controlled trials (RCT) for pancreatic adenocarcinoma published between 2000 and 2008 identified through a standard MEDLINE literature search strategy, according to a standardized, previ ... Full text Link to item Cite

Prognostic impact of RT-PCR-based detection of peritoneal micrometastases in patients with pancreatic cancer undergoing curative resection.

Journal Article Ann Surg Oncol · December 2009 BACKGROUND: Positive peritoneal fluid cytology predicts poor outcome in patients with resected pancreatic cancer. Reverse transcription-polymerase chain reaction (RT-PCR) has been proposed as a more sensitive means of detection of peritoneal micrometastase ... Full text Link to item Cite

A matched case-control study of preoperative biliary drainage in patients with pancreatic adenocarcinoma: routine drainage is not justified.

Journal Article J Gastrointest Surg · December 2009 BACKGROUND: Preoperative biliary drainage (PBD) prior to pancreaticoduodenectomy (PD) continues to be routine in many centers despite retrospective and randomized data showing that PBD increases perioperative infectious complications. METHODS: Review of a ... Full text Link to item Cite

Laparoscopic versus open liver resection: a matched-pair case control study.

Journal Article J Gastrointest Surg · December 2009 BACKGROUND: Laparoscopic liver resection (LLR) has become an increasingly popular operation; however, its theoretical benefits remain unproven. The aim of this study was to conduct a comparative outcome study between LLR and matched-pair open liver resecti ... Full text Link to item Cite

Pancreatic cyst fluid protein expression profiling for discriminating between serous cystadenoma and intraductal papillary mucinous neoplasm.

Journal Article Ann Surg · November 2009 BACKGROUND: Many patients with benign serous cystadenoma (SCA) of the pancreas will undergo resection because of the inability to reliably discriminate between SCA and premalignant mucinous cysts (intraductal papillary mucinous neoplasm [IPMN], mucinous cy ... Full text Link to item Cite

Defining surgical indications for type I gastric carcinoid tumor.

Journal Article Ann Surg Oncol · November 2009 BACKGROUND: Most gastric carcinoid tumors (GC) (type I) occur in association with achlorhydria, hypergastrinemia, atrophic gastritis and exhibit low-grade histopathology. The management of this indolent disease is controversial. The aim of this study was t ... Full text Link to item Cite

Role of preoperative biliary drainage of liver remnant prior to extended liver resection for hilar cholangiocarcinoma

Journal Article HPB · August 1, 2009 Background: In patients with hilar cholangiocarcinoma, ipsilateral en bloc hepatic resection improves survival but is associated with increased morbidity. Preoperative biliary drainage of the future liver remnant (FLR) and contralateral portal vein emboliz ... Full text Cite

Response to neoadjuvant chemotherapy does not predict overall survival for patients with synchronous colorectal hepatic metastases.

Journal Article Ann Surg Oncol · July 2009 OBJECTIVE: We investigated the relation between response to neoadjuvant chemotherapy and overall survival (OS) in patients with colorectal liver metastases (CLM). BACKGROUND: It has previously been reported that patients with synchronous CLM whose disease ... Full text Link to item Cite

Pancreatic adenocarcinoma in a young patient population--12-year experience at Memorial Sloan Kettering Cancer Center.

Journal Article J Surg Oncol · July 1, 2009 BACKGROUND: There is a dearth of data in a younger population of patients with pancreatic ductal adenocarcinoma (PAC) regarding epidemiology, genetics, prognosis, and outcome. This report examines a large cohort of patients with PAC Full text Link to item Cite

Laparoscopic versus open subtotal gastrectomy for adenocarcinoma: a case-control study.

Journal Article Ann Surg Oncol · June 2009 OBJECTIVE: The aim of this study is to compare technical feasibility and oncologic efficacy of totally laparoscopic versus open subtotal gastrectomy for gastric adenocarcinoma. BACKGROUND: Laparoscopic gastrectomy for adenocarcinoma is emerging in the West ... Full text Link to item Cite

Genome wide analysis and clinical correlation of chromosomal and transcriptional mutations in cancers of the biliary tract.

Journal Article J Exp Clin Cancer Res · May 12, 2009 BACKGROUND: The pathogenesis of biliary cancers is ill-defined. This study investigates changes in gene expression and copy number in biliary cancers and correlates these changes with anatomical site of origin, histopathology and outcome. METHODS: We perfo ... Full text Link to item Cite

Polypoid lesions of the gallbladder: diagnosis and followup.

Journal Article J Am Coll Surg · April 2009 BACKGROUND: Polypoid lesions of the gallbladder (PLG) are commonly seen on ultrasonography (US), but optimal management of this problem is ill-defined. The aims of this study were to assess the natural history and the histologic characteristics of US-detec ... Full text Link to item Cite

BRCA germline mutations in Jewish patients with pancreatic adenocarcinoma.

Journal Article J Clin Oncol · January 20, 2009 PURPOSE: The prognostic significance of germline BRCA1 and BRCA2 mutations in Jewish patients with pancreatic adenocarcinoma (PAC) is unknown. Our objective was to define the prevalence of BRCA1 and BRCA2 in an unselected group of Jewish patients and to co ... Full text Link to item Cite

Recurrence patterns of intraductal papillary mucinous neoplasms of the pancreas on enhanced computed tomography.

Journal Article J Comput Assist Tomogr · 2009 OBJECTIVE: To characterize imaging features and findings in recurrent intraductal papillary mucinous neoplasms (IPMN); thereby reconciling the "field defect" theory with the appearance of recurrences distant from the resection margin. METHODS: Computed tom ... Full text Link to item Cite

Preoperative CA 19-9 and the yield of staging laparoscopy in patients with radiographically resectable pancreatic adenocarcinoma.

Journal Article Ann Surg Oncol · December 2008 BACKGROUND: Staging laparoscopy for patients with radiographically resectable pancreatic adenocarcinoma has been reported to yield an 8-15% finding of unresectable disease. Factors associated with the likelihood of subradiographic unresectable disease have ... Full text Link to item Cite

PEGylated gold nanoparticles conjugated to monoclonal F19 antibodies as targeted labeling agents for human pancreatic carcinoma tissue.

Journal Article ACS Nano · November 25, 2008 In this study, we describe optical detection of antibody-conjugated nanoparticles bound to surgically resected human pancreatic cancer tissue. Gold nanoparticles stabilized by heterobifunctional polyethylene glycol (PEG) were prepared using approximately 1 ... Full text Link to item Cite

Extrahepatic cholangiocarcinoma: A comparison of patients with resected proximal and distal lesions

Conference HPB · October 1, 2008 Purpose. Disease-specific survival (DSS) for proximal bile duct cancer has been reported to be worse than for carcinoma of the distal duct. Methods. Review of two prospectively maintained databases identified 204 patients who underwent resection for extrah ... Full text Cite

Current management of cystic neoplasms of the pancreas.

Journal Article Surgeon · October 2008 Over the last decade there has been a dramatic increase in the number of patients identified with pancreatic cysts. This increase has been largely attributed to advances in imaging. The majority of these cysts represent benign neoplasms; however, a signifi ... Full text Link to item Cite

Management and outcomes of postpancreatectomy fistula, leak, and abscess: results of 908 patients resected at a single institution between 2000 and 2005.

Journal Article J Am Coll Surg · October 2008 BACKGROUND: Anastomotic fistula, leak, and abscess are common complications of pancreatectomy. The goal of this study was to describe our current management and outcomes of clinically significant postpancreatectomy fistula, leak, and abscess. STUDY DESIGN: ... Full text Link to item Cite

Pancreatic adenocarcinoma: the actual 5-year survivors.

Journal Article J Gastrointest Surg · April 2008 BACKGROUND: Most reports of patients undergoing resection for pancreatic adenocarcinoma report estimated (actuarial) 5-year survival rates. Actual 5-year survival is rarely described, and factors associated with long-term survival are not well described. M ... Full text Link to item Cite

Current utility of staging laparoscopy for pancreatic and peripancreatic neoplasms.

Journal Article J Am Coll Surg · March 2008 BACKGROUND: The routine use of staging laparoscopy in patients with radiographically resectable pancreatic and peripancreatic neoplasms remains controversial. STUDY DESIGN: We reviewed a prospective database that identified 1,045 patients who underwent sta ... Full text Link to item Cite

Preoperative predictors for complications after pancreaticoduodenectomy: impact of BMI and body fat distribution.

Journal Article J Gastrointest Surg · February 2008 BACKGROUND: The purpose of this study was to examine the preoperative patient and radiographic factors that are associated with operative morbidity after pancreaticoduodenectomy. MATERIAL AND METHODS: Patient characteristics and preoperative radiographic f ... Full text Link to item Cite

Determining prognosis in patients with pancreatic endocrine neoplasms: can the WHO classification system be simplified?

Journal Article J Clin Oncol · December 10, 2007 PURPOSE: The WHO classification for well-differentiated pancreatic endocrine neoplasms (PENs) incorporates both stage and grade. This study compares the prognostic value of a simplified staging and grading system with the WHO system in a large single-insti ... Full text Link to item Cite

Detection of micrometastases in peritoneal washings of pancreatic cancer patients by the reverse transcriptase polymerase chain reaction.

Journal Article J Gastrointest Surg · December 2007 OBJECTIVE: Pancreatic cancer patients with positive (+) peritoneal cytology have a prognosis similar to stage IV patients. We studied the ability of quantitative real time-polymerase chain reaction (RT-PCR) to detect micrometastases in patients undergoing ... Full text Link to item Cite

Utility of a prognostic nomogram designed for gastric cancer in predicting outcome of patients with R0 resected duodenal adenocarcinoma.

Journal Article Ann Surg Oncol · November 2007 BACKGROUND: There is little information to determine prognosis or to guide clinical care for patients with duodenal adenocarcinoma. We have hypothesized that survival following resection of duodenal cancer is similar to survival following resection of dist ... Full text Link to item Cite

Prognostic significance of pathologic nodal status in patients with resected pancreatic cancer.

Journal Article J Gastrointest Surg · November 2007 BACKGROUND: The purpose of this study was to evaluate the significance of pathologic nodal assessment and extent of nodal metastases on patient outcome in patients with pancreatic adenocarcinoma. MATERIALS AND METHODS: A prospectively maintained pancreatic ... Full text Link to item Cite

Fate of the remnant pancreas after resection of noninvasive intraductal papillary mucinous neoplasm.

Journal Article J Am Coll Surg · May 2007 BACKGROUND: The risk of local recurrence in the pancreatic remnant after resection of noninvasive intraductal papillary mucinous neoplasm (IPMN) is not well defined. STUDY DESIGN: We performed a retrospective review of a prospectively maintained pancreatic ... Full text Link to item Cite

Fasciitis ossificans with a radial neuropathy: a benign differential diagnosis for soft tissue sarcoma.

Journal Article J Clin Neurosci · April 2007 A soft tissue mass with an associated neuropathy suggests a malignancy with nerve compression or infiltration. However, there are benign diagnoses to consider. We report a case of an axillary mass with a radial nerve neuropathy, initially suspected to be a ... Full text Link to item Cite

Defining morbidity after pancreaticoduodenectomy: use of a prospective complication grading system.

Journal Article J Am Coll Surg · March 2007 BACKGROUND: Improving surgical quality of care requires accurate reporting of postoperative complications. STUDY DESIGN: Accuracy of a prospective surgical complication grading database was assessed by performing a retrospective review of 204 pancreaticodu ... Full text Link to item Cite

The management of cystic lesions of the pancreas.

Book · 2007 The number of patients being identified as having asymptomatic small cysts of the pancreas is increasing. Most cystic neoplasms are SCAs, IPMNs, or MCNs. SCAs should be considered benign and in the absence of symptoms can be safely followed radiographicall ... Full text Link to item Cite

The influence of positive peritoneal cytology on survival in patients with pancreatic adenocarcinoma.

Journal Article J Gastrointest Surg · December 2006 The American Joint Committee on Cancer (AJCC) staging system for pancreatic adenocarcinoma classifies positive peritoneal cytology as stage IV disease. Data are limited with respect to the prevalence of positive peritoneal cytology and its influence on sur ... Full text Link to item Cite

The utility of F-18 fluorodeoxyglucose whole body PET imaging for determining malignancy in cystic lesions of the pancreas.

Journal Article J Gastrointest Surg · December 2006 Previous studies have suggested that whole body positron-emission tomography (PET) can distinguish between benign and malignant cysts of the pancreas. Patients were identified (n = 68) who had undergone whole body PET imaging for a cystic lesion of the pan ... Full text Link to item Cite

A selective approach to the resection of cystic lesions of the pancreas: results from 539 consecutive patients.

Journal Article Ann Surg · October 2006 OBJECTIVE: To define a group of patients with pancreatic cysts who do not require resection. SUMMARY BACKGROUND DATA: The increased use of cross-sectional imaging has resulted in an increased identification of small, asymptomatic pancreatic cysts. Data hav ... Full text Link to item Cite

In reply [9]

Journal Article Journal of Clinical Oncology · December 1, 2005 Full text Cite

Technical complications and durability of hepatic artery infusion pumps for unresectable colorectal liver metastases: an institutional experience of 544 consecutive cases.

Journal Article J Am Coll Surg · July 2005 BACKGROUND: Hepatic arterial infusion pump chemotherapy is an important component in the treatment of patients with hepatic metastases. Successful use of a hepatic arterial infusion pump requires a low technical complication rate. We evaluated the complica ... Full text Link to item Cite

Merkel cell carcinoma: prognosis and treatment of patients from a single institution.

Journal Article J Clin Oncol · April 1, 2005 PURPOSE: Merkel cell carcinoma (MCC) is an uncommon cutaneous malignancy. Most reports consist of single-institution experiences of fewer than 30 patients. The natural history of MCC is poorly defined. PATIENTS AND METHODS: A review was performed of Memori ... Full text Link to item Cite

A new and improved vitreoretinal erbium:YAG laser scalpel: long-term morphologic characteristics of retinal-choroidal injury.

Journal Article Ophthalmic Surg Lasers Imaging · 2004 BACKGROUND AND OBJECTIVE: To report a modified erbium:YAG laser scalpel designed to incise tissue more efficiently and safely than other systems reported to date. MATERIALS AND METHODS: An erbium:YAG laser delivery system was built to deliver laser energy ... Link to item Cite

Cystic lesions of the pancreas: selection criteria for operative and nonoperative management in 209 patients.

Conference J Gastrointest Surg · December 2003 Because of the inability to determine benign from malignant, many have recommended that all cystic lesions of the pancreas be resected. Patients evaluated between January 1995 and December 2000 for the ICD-9 diagnosis of pancreatic cyst (577.2) or benign n ... Full text Link to item Cite

Impact of steatosis on perioperative outcome following hepatic resection.

Conference J Gastrointest Surg · December 2003 Fatty liver disease may interfere with liver regeneration and is postulated to result in an adverse outcome for patients subjected to partial hepatectomy. This study examines the impact of steatosis on outcome following hepatic resection for neoplasms. All ... Full text Link to item Cite

Current status of hepatic resection.

Book · 2003 During the past 2 decades, an improved understanding of hepatic anatomy and advances in surgical technique have allowed for hepatic resection to be performed with operative mortality rates between 1% and 5%. With this low mortality, hepatic resection is no ... Link to item Cite

Importance of response to neoadjuvant chemotherapy in patients undergoing resection of synchronous colorectal liver metastases.

Journal Article J Gastrointest Surg · January 2003 The purpose of this study was to compare the treatment and outcome in patients referred for staged resection of synchronous colorectal liver metastases. The records of patients who had undergone colon or rectal resection and were then referred for evaluati ... Full text Link to item Cite

Primary adult soft tissue sarcoma: time-dependent influence of prognostic variables.

Journal Article J Clin Oncol · November 1, 2002 PURPOSE: To define prognostic factors for postrelapse survival and their time-dependent influence for adult soft tissue sarcoma (STS). PATIENTS AND METHODS: We analyzed 2,123 patients with completely resected localized primary STS treated from 1982 to 1999 ... Full text Link to item Cite

The management of variant arterial anatomy during hepatic arterial infusion pump placement.

Journal Article Ann Surg Oncol · November 2002 BACKGROUND: The success of hepatic arterial infusion pump (HAIP) placement in patients with variant arterial anatomy has not been well described. METHODS: Patients who underwent HAIP placement over a 5-year time period were evaluated. Arterial- and cathete ... Full text Link to item Cite

The surgical management of metastatic melanoma.

Journal Article Ann Surg Oncol · October 2002 When deciding whether or not to perform a resection for metastatic melanoma, one should follow general principles that apply to the patient with melanoma as well as to the patient with metastases from other types of primary tumors. When the resection is pa ... Full text Link to item Cite

The role of surgery for patients with metastatic melanoma.

Journal Article Curr Opin Oncol · March 2002 When deciding to perform a resection for metastatic melanoma one should first decide whether the intent of the procedure is curative or palliative. When the resection is palliative, the success of surgical treatment will depend on the presence of identifia ... Full text Link to item Cite

Metastatic carcinoid tumour presenting as hepatic encephalopathy

Journal Article HPB · January 1, 2002 Background: Hepatic encephalopathy is rarely encountered with carcinoid syndrome, but massive hepatic replacement by carcinoid tumour can cause neuropsychiatric alterations. Case outline: A man of 42 years presented with carcinoid syndrome accompanied by f ... Full text Cite

Value of frozen-section analysis of sentinel lymph nodes for primary cutaneous malignant melanoma.

Journal Article Ann Surg · January 2002 OBJECTIVE: To analyze a large, single-institution experience with routine frozen section (FS) of the sentinel lymph node (SLN) in patients with primary cutaneous melanoma. SUMMARY BACKGROUND DATA: Controversy exists over the utility of intraoperative FS an ... Full text Link to item Cite

Immunohistochemical analysis of sentinel lymph nodes from patients with Merkel cell carcinoma.

Journal Article Cancer · September 15, 2001 BACKGROUND: Immunohistochemical analysis of sentinel lymph nodes from patients with breast carcinoma and melanoma has been shown to increase the sensitivity for detecting lymph node metastases. To the authors' knowledge, this technique has not been describ ... Full text Link to item Cite

Herpes simplex virus (HSV)-mediated ICAM-1 gene transfer abrogates tumorigenicity and induces anti-tumor immunity.

Journal Article Mol Med · September 1999 BACKGROUND: Costimulatory and cellular adhesion molecules are thought to be essential components of antigen presentation in the immune response to cancer. The current studies examine gene transfer utilizing herpes viral amplicon vectors (HSV) to direct sur ... Link to item Cite

Desmoid tumors of the chest wall.

Journal Article Semin Thorac Cardiovasc Surg · July 1999 Desmoid tumors are rare soft tissue neoplasms derived from fascial or musculoaponeurotic structures. These tumors are histologically benign but may behave aggressively at the local level with multiple recurrences after complete resection being common. Ches ... Full text Link to item Cite

Merkel cell carcinoma.

Journal Article Aust N Z J Surg · February 1999 Full text Link to item Cite

Surgical management of Merkel cell carcinoma.

Journal Article Ann Surg · January 1999 OBJECTIVES: To characterize the natural history of Merkel cell carcinoma (MCC) and to analyze the influence of patient, tumor, and treatment-related variables on survival and recurrence. SUMMARY BACKGROUND DATA: Approximately 425 cases of MCC have been des ... Full text Link to item Cite

The effects of hepatic cryosurgery on tumor growth in the liver.

Journal Article J Surg Res · July 1, 1998 BACKGROUND: The effects of hepatic cryosurgery on residual hepatic tumor growth, and on tumor immunity, have not been determined. MATERIALS AND METHODS: Two experiments were performed. In both, animals (n = 10 per group) had solitary left lobe hepatomas es ... Full text Link to item Cite

Contributions from surgeons to clinical trials and research on the management of soft tissue sarcoma.

Journal Article Ann Surg Oncol · 1998 BACKGROUND: Surgical resection is the primary treatment for soft tissue sarcoma. Surgeons are in a position to develop and define appropriate treatment strategies for this disease. In an effort to define the contributions of surgeons to the management of s ... Full text Link to item Cite

Saphenous vein versus polytetrafluoroethylene carotid patch angioplasty.

Conference Am J Surg · August 1997 BACKGROUND: The optimal material for carotid patch angioplasty after endarterectomy remains uncertain. This study compares the early outcome and recurrent stenosis rates between saphenous vein (SV) and expanded polytetrafluoroethylene (ePTFE) carotid patch ... Full text Link to item Cite

Lower extremity lymphedema caused by acquired immune deficiency syndrome-related Kaposi's sarcoma: case report and review of the literature.

Journal Article J Vasc Surg · August 1995 A case of severe lymphedema of the lower extremity caused by obstruction by human immunodeficiency virus-associated Kaposi's sarcoma is presented. A review of the signs and symptoms of obstructive lymphedema and Kaposi's sarcoma is provided. Early recognit ... Full text Link to item Cite