Scholars@Duke
Robert Matthew Tighe

Robert Matthew Tighe

Associate Professor of Medicine
Medicine, Pulmonary, Allergy, and Critical Care Medicine
robert.tighe@duke.edu
Duke Box 2629, Durham, NC 27710
Duke Pulmonary- Medical Resear, 203 Research Drive, Durham, NC 27710

Selected Publications

Profibrotic monocyte-derived alveolar macrophages are expanded in patients with persistent respiratory symptoms and radiographic abnormalities after COVID-19.

Journal Article Nat Immunol · November 2024 Monocyte-derived alveolar macrophages drive lung injury and fibrosis in murine models and are associated with pulmonary fibrosis in humans. Monocyte-derived alveolar macrophages have been suggested to develop a phenotype that promotes lung repair as injury ... Full text Link to item Cite

Hyperpolarized 129Xe MRI and spectroscopy of gas exchange abnormalities in chronic hypersensitivity pneumonitis.

Journal Article Respir Med · October 5, 2024 PURPOSE: To evaluate 3D gas-exchange functional imaging characteristics using 129Xe MRI in a group of study participants with chronic hypersensitivity pneumonitis (CHP) as compared with healthy control participants. METHODS: In this prospective study, 11 p ... Full text Link to item Cite

Cellular and In Vivo Response to Industrial, Food Grade, and Photocatalytic TiO2 Nanoparticles.

Journal Article J Phys Chem B · September 19, 2024 We encounter titanium dioxide nanoparticles (TiO2 NPs) throughout our daily lives in the form of food coloring, cosmetics, and industrial materials. They are used on a massive industrial scale, with over 1 million metric tons in the global market. For the ... Full text Link to item Cite

Tissue-Resident Alveolar Macrophages Reduce Ozone-induced Inflammation via MerTK-mediated Efferocytosis.

Journal Article Am J Respir Cell Mol Biol · June 2024 Lung inflammation, caused by acute exposure to ozone (O3), one of the six criteria air pollutants, is a significant source of morbidity in susceptible individuals. Alveolar macrophages (AMØs) are the most abundant immune cells in the normal lung, and their ... Full text Link to item Cite

Soil exposure modulates the immune response to an influenza challenge in a mouse model.

Journal Article Sci Total Environ · April 20, 2024 There is increasing evidence that early life microbial exposure aids in immune system maturation, more recently known as the "old friends" hypothesis. To test this hypothesis, 4-week-old mice were exposed to soils of increasing microbial diversity for four ... Full text Link to item Cite

Prolonged exposure to lung-derived cytokines is associated with activation of microglia in patients with COVID-19.

Journal Article JCI Insight · March 19, 2024 BACKGROUNDSurvivors of pneumonia, including SARS-CoV-2 pneumonia, are at increased risk for cognitive dysfunction and dementia. In rodent models, cognitive dysfunction following pneumonia has been linked to the systemic release of lung-derived pro-inflamma ... Full text Link to item Cite

Biocidal products: Opportunities in risk assessment, management, and communication.

Journal Article Risk Anal · February 2024 In the coronavirus disease 2019 era, biocidal products are increasingly used for controlling harmful organisms, including microorganisms. However, assuring safety against adverse health effects is a critical issue from a public health standpoint. This stud ... Full text Link to item Cite

House Dust Mite Extract Forms a Der p 2 Corona on Multi-Walled Carbon Nanotubes: Implications for Allergic Airway Disease.

Journal Article Environ Sci Nano · January 1, 2024 Multi-walled carbons nanotubes (MWCNTs) are used in materials for the construction, automotive, and aerospace industries. Workers and consumers are exposed to these materials via inhalation. Existing recommended exposure limits are based on MWCNT exposures ... Full text Link to item Cite

Altered ontogeny and transcriptomic signatures of tissue-resident pulmonary interstitial macrophages ameliorate allergic airway hyperresponsiveness.

Journal Article Front Immunol · 2024 INTRODUCTION: Environmental exposures and experimental manipulations can alter the ontogenetic composition of tissue-resident macrophages. However, the impact of these alterations on subsequent immune responses, particularly in allergic airway diseases, re ... Full text Link to item Cite

Investigating sensitization activity of azobenzene disperse dyes via the Direct Peptide Reactivity Assay (DPRA).

Journal Article Food Chem Toxicol · December 2023 Azobenzene disperse dyes are the fastest-growing category of commercial dyestuffs and have been found in indoor house dust and in children's polyester apparel. Azobenzene disperse dyes are implicated as potentially allergenic; however, little experimental ... Full text Link to item Cite

Tissue-resident alveolar macrophages reduce O3-induced inflammation via MerTK mediated efferocytosis.

Journal Article bioRxiv · November 6, 2023 Lung inflammation, caused by acute exposure to ozone (O3) - one of the six criteria air pollutants - is a significant source of morbidity in susceptible individuals. Alveolar macrophages (AMØs) are the most abundant immune cells in the normal lung and thei ... Full text Link to item Cite

Linking Adiposity to Interstitial Lung Disease: The Role of the Dysfunctional Adipocyte and Inflammation.

Journal Article Cells · September 5, 2023 Adipose tissue has functions beyond its principal functions in energy storage, including endocrine and immune functions. When faced with a surplus of energy, the functions of adipose tissue expand by mechanisms that can be both adaptive and detrimental. Th ... Full text Link to item Cite

Interaction of TiO2 nanoparticles with lung fluid proteins and the resulting macrophage inflammatory response.

Journal Article Environ Sci Nano · September 1, 2023 Inhalation is a major exposure route to nanoparticles. Following inhalation, nanoparticles first interact with the lung lining fluid, a complex mixture of proteins, lipids, and mucins. We measure the concentration and composition of lung fluid proteins ads ... Full text Link to item Cite

Lethal eosinophilic crystalline pneumonia in mice expressing a stabilized Csf2 mRNA.

Journal Article FASEB J · August 2023 Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a cytokine that stimulates the proliferation and differentiation of granulocyte and macrophage precursors. The mouse gene-encoding GM-CSF, Csf2, is regulated at both transcriptional and post-tran ... Full text Link to item Cite

Prolonged exposure to lung-derived cytokines is associated with inflammatory activation of microglia in patients with COVID-19.

Journal Article bioRxiv · July 28, 2023 Neurological impairment is the most common finding in patients with post-acute sequelae of COVID-19. Furthermore, survivors of pneumonia from any cause have an elevated risk of dementia1-4. Dysfunction in microglia, the primary immune cell in the brain, ha ... Full text Link to item Cite

Maternal exposure to ultrafine particles enhances influenza infection during pregnancy.

Journal Article Part Fibre Toxicol · April 17, 2023 BACKGROUND: Interactions between air pollution and infectious agents are increasingly recognized and critical to identify, especially to protect vulnerable populations. Pregnancy represents a vulnerable period for influenza infection and air pollution expo ... Full text Link to item Cite

Lung-gut axis of microbiome alterations following co-exposure to ultrafine carbon black and ozone.

Journal Article Particle and fibre toxicology · April 2023 BackgroundMicrobial dysbiosis is a potential mediator of air pollution-induced adverse outcomes. However, a systemic comparison of the lung and gut microbiome alterations and lung-gut axis following air pollution exposure is scant. In this study, ... Full text Cite

Air pollution and respiratory infections: the past, present, and future.

Journal Article Toxicol Sci · March 20, 2023 Air pollution levels across the globe continue to rise despite government regulations. The increase in global air pollution levels drives detrimental human health effects, including 7 million premature deaths every year. Many of these deaths are attributab ... Full text Link to item Cite

Inhalation of an RNA aptamer that selectively binds extracellular histones protects from acute lung injury.

Journal Article Mol Ther Nucleic Acids · March 14, 2023 Acute lung injury (ALI) is a syndrome of acute inflammation, barrier disruption, and hypoxemic respiratory failure associated with high morbidity and mortality. Diverse conditions lead to ALI, including inhalation of toxic substances, aspiration of gastric ... Full text Open Access Link to item Cite

Scavenger receptor BI attenuates oxidized phospholipid-induced pulmonary inflammation.

Journal Article Toxicol Appl Pharmacol · March 1, 2023 Damage associated molecular patterns (DAMPs) are molecules released from dead/dying cells following toxicant and/or environmental exposures that activate the immune response through binding of pattern recognition receptors (PRRs). Excessive production of D ... Full text Link to item Cite

Vertical sleeve gastrectomy associates with airway hyperresponsiveness in a murine model of allergic airway disease and obesity.

Journal Article Front Endocrinol (Lausanne) · 2023 INTRODUCTION: Asthma is a chronic airway inflammatory disease marked by airway inflammation, remodeling and hyperresponsiveness to allergens. Allergic asthma is normally well controlled through the use of beta-2-adrenergic agonists and inhaled corticostero ... Full text Open Access Link to item Cite

Co-occurrence of pneumoconiosis with COPD, pneumonia and lung cancer.

Journal Article Occup Med (Lond) · December 7, 2022 BACKGROUND: Pneumoconiosis is a well-documented occupational disease that is linked to conditions such as chronic obstructive pulmonary disease (COPD), pneumonia and congestive heart failure. Pneumoconiosis prevalence has decreased in the United States, bu ... Full text Link to item Cite

The Eyes Have It-for Idiopathic Pulmonary Fibrosis: a Preliminary Observation.

Journal Article Pulm Ther · September 2022 INTRODUCTION: The disease origins of idiopathic pulmonary fibrosis (IPF), which occurs at higher rates in certain races/ethnicities, are not understood. The highest rates occur in white persons of European descent, particularly those with light skin, who a ... Full text Open Access Link to item Cite

Mouse pulmonary interstitial macrophages mediate the pro-tumorigenic effects of IL-9.

Journal Article Nat Commun · July 1, 2022 Although IL-9 has potent anti-tumor activity in adoptive cell transfer therapy, some models suggest that it can promote tumor growth. Here, we show that IL-9 signaling is associated with poor outcomes in patients with various forms of lung cancer, and is r ... Full text Link to item Cite

Exogenous leptin enhances markers of airway fibrosis in a mouse model of chronic allergic airways disease.

Journal Article Respir Res · May 24, 2022 BACKGROUND: Asthma patients with comorbid obesity exhibit increased disease severity, in part, due to airway remodeling, which is also observed in mouse models of asthma and obesity. A mediator of remodeling that is increased in obesity is leptin. We hypot ... Full text Open Access Link to item Cite

An IL-9-pulmonary macrophage axis defines the allergic lung inflammatory environment.

Journal Article Sci Immunol · February 18, 2022 Despite IL-9 functioning as a pleiotropic cytokine in mucosal environments, the IL-9-responsive cell repertoire is still not well defined. Here, we found that IL-9 mediates proallergic activities in the lungs by targeting lung macrophages. IL-9 inhibits al ... Full text Link to item Cite

Hyaluronan Regulation of AT2 Cell Proliferation at the Terminal Airway Following Ozone Exposure Is Age Dependent

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · 2022 Cite

Ozone-Induced Models of Airway Hyperreactivity and Epithelial Injury.

Journal Article Methods Mol Biol · 2022 Ozone (O3), a criterion air pollutant produced as a product of internal combustion, generates increased inflammation, lung permeability, and airway hyperreactivity when exposed to rodents in laboratory settings. Airway hyperreactivity is defined as an exag ... Full text Link to item Cite

Autoreactive B cells recruited to lungs by silica exposure contribute to local autoantibody production in autoimmune-prone BXSB and B cell receptor transgenic mice.

Journal Article Front Immunol · 2022 Occupational exposure to inhaled crystalline silica dust (cSiO2) is linked to systemic lupus erythematosus, rheumatoid arthritis, systemic sclerosis, and anti-neutrophil cytoplasmic autoantibody vasculitis. Each disease has a characteristic autoantibody pr ... Full text Link to item Cite

Hyperpolarized 129Xe MRI and Spectroscopy of Gas-Exchange Abnormalities in Nonspecific Interstitial Pneumonia.

Journal Article Radiology · October 2021 Background Recent studies demonstrate that antifibrotic drugs previously reserved for idiopathic pulmonary fibrosis (IPF) may slow progression in other interstitial lung diseases (ILDs), creating an urgent need for tools that can sensitively assess disease ... Full text Link to item Cite

Wood smoke particle exposure in mice reduces the severity of influenza infection.

Journal Article Toxicol Appl Pharmacol · September 1, 2021 Elevated ambient temperatures and extreme weather events have increased the incidence of wildfires world-wide resulting in increased wood smoke particle (WSP). Epidemiologic data suggests that WSP exposure associates with exacerbations of respiratory disea ... Full text Open Access Link to item Cite

Sex Differences in Pulmonary Eicosanoids and Specialized Pro-Resolving Mediators in Response to Ozone Exposure.

Journal Article Toxicol Sci · August 30, 2021 Ozone (O3) is a criteria air pollutant known to increase the morbidity and mortality of cardiopulmonary diseases. This occurs through a pulmonary inflammatory response characterized by increased recruitment of immune cells into the airspace, pro-inflammato ... Full text Link to item Cite

Scavenger Receptor BI Attenuates IL-17A-Dependent Neutrophilic Inflammation in Asthma.

Journal Article Am J Respir Cell Mol Biol · June 2021 Asthma is a common respiratory disease currently affecting more than 300 million worldwide and is characterized by airway inflammation, hyperreactivity, and remodeling. It is a heterogeneous disease consisting of corticosteroid-sensitive T-helper cell type ... Full text Link to item Cite

Role of Innate Immune System in Environmental Lung Diseases.

Journal Article Curr Allergy Asthma Rep · May 10, 2021 The lung mucosa functions as a principal barrier between the body and inhaled environmental irritants and pathogens. Precise and targeted surveillance mechanisms are required at this lung-environment interface to maintain homeostasis and preserve gas excha ... Full text Link to item Cite

Using hyperpolarized 129Xe gas-exchange MRI to model the regional airspace, membrane, and capillary contributions to diffusing capacity.

Journal Article J Appl Physiol (1985) · May 1, 2021 Hyperpolarized 129Xe MRI has emerged as a novel means to evaluate pulmonary function via 3D mapping of ventilation, interstitial barrier uptake, and RBC transfer. However, the physiological interpretation of these measurements has yet to be firmly establis ... Full text Link to item Cite

What Is "Normal" When Examining Myeloid Cells in Human Airways?

Journal Article Am J Respir Crit Care Med · April 15, 2021 Full text Link to item Cite

The environment shapes swine lung bacterial communities.

Journal Article Sci Total Environ · March 1, 2021 Previous studies of the lung microbiome have focused on characterizing the community and attempts to understand the role of community membership concerning disease or exposures such as cigarette smoke. However, we still lack an understanding of two critica ... Full text Link to item Cite

Novel Mechanisms of Ozone-Induced Pulmonary Inflammation and Resolution, and the Potential Protective Role of Scavenger Receptor BI.

Journal Article Res Rep Health Eff Inst · March 2021 INTRODUCTION: Increases in ambient levels of ozone (O3), a criteria air pollutant, have been associated with increased susceptibility and exacerbations of chronic pulmonary diseases through lung injury and inflammation. O3 induces pulmonary inflammation, i ... Link to item Cite

Genetic variation in surfactant protein-A2 alters responses to ozone.

Journal Article PLoS One · 2021 BACKGROUND: Increased exposure to Ozone (O3) is associated with adverse health effects in individuals afflicted with respiratory diseases. Surfactant protein-A (SP-A), encoded by SP-A1 and SP-A2, is the largest protein component in pulmonary surfactant and ... Full text Link to item Cite

Interstitial lung disease in a veterans affairs regional network; a retrospective cohort study.

Journal Article PLoS One · 2021 BACKGROUND: The epidemiology of Interstitial Lung Diseases (ILD) in the Veterans Health Administration (VHA) is presently unknown. RESEARCH QUESTION: Describe the incidence/prevalence, clinical characteristics, and outcomes of ILD patients within the Veter ... Full text Open Access Link to item Cite

Woodsmoke Particle Exposure in Mice Confers Protective Benefit Against PR8 Influenza Virus

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · 2021 Cite

Repetitive Ozone Exposures and Evaluation of Pulmonary Inflammation and Remodeling in Diabetic Mouse Strains.

Journal Article Environ Health Perspect · November 2020 BACKGROUND: Epidemiological studies support the hypothesis that diabetes alters pulmonary responses to air pollutants like ozone (O3). The mechanism(s) underlying these associations and potential links among diabetes, O3, and lung inflammation and remodeli ... Full text Link to item Cite

Ozone Responses and Diet: Does Sex Determine the Relationship?

Journal Article Am J Respir Cell Mol Biol · April 2020 Full text Link to item Cite

TLR5 participates in the TLR4 receptor complex and promotes MyD88-dependent signaling in environmental lung injury.

Journal Article Elife · January 28, 2020 Lung disease causes significant morbidity and mortality, and is exacerbated by environmental injury, for example through lipopolysaccharide (LPS) or ozone (O3). Toll-like receptors (TLRs) orchestrate immune responses to injury by recognizing pathogen- or d ... Full text Link to item Cite

Hyperpolarized 129Xe Magnetic Resonance Imaging Is Sensitive to Therapy Response in Idiopathic Pulmonary Fibrosis

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · 2020 Cite

Deficiency in Paraoxonase 2 Increases Airway Hyper Responsiveness After Ozone Exposure in Mice

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · 2020 Cite

Glucagon Like Peptide 1 Attenuates Airway Hyperresponsiveness in a Mouse Model of Obese Allergic Asthma

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · 2020 Cite

Using 129Xenon MR Gas Exchange MRI to Measure the Membrane and Capillary Components of DLCO and KCO

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · 2020 Cite

Hyperpolarized 129Xe Magnetic Resonance Imaging Measures of Gas Exchange in Non-Specific Interstitial Pneumonia

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · 2020 Cite

IRAK-M Regulates Airway Hyperreactivity in a Novel Model of Ozone Induced Allergic Inflammation

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · 2020 Cite

Hyperpolarized 129Xe MRI of Regional Capillary-Level Cardio-Pulmonary Dynamics Predict Outcomes in IPF Patients

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · 2020 Cite

Management of Idiopathic Pulmonary Fibrosis.

Journal Article Ann Pharmacother · December 2019 Objective: Provide information for pharmacists on idiopathic pulmonary fibrosis (IPF) and its treatment. Study Selection and Data Extraction: All articles with data from randomized controlled trials of nintedanib or pirfenidone were reviewed. Data Synthesi ... Full text Link to item Cite

Physiologic response to chronic house dust mite exposure in mice is dependent on lot characteristics.

Conference J Allergy Clin Immunol · November 2019 Physiological responses to HDM extracts are variable. To increase the transparency and reproducibility of published work, lot numbers, concentration of extract components, and methods for dose normalization need to be thoroughly reported. ... Full text Link to item Cite

Improving the Quality and Reproducibility of Flow Cytometry in the Lung. An Official American Thoracic Society Workshop Report.

Journal Article Am J Respir Cell Mol Biol · August 2019 Defining responses of the structural and immune cells in biologic systems is critically important to understanding disease states and responses to injury. This requires accurate and sensitive methods to define cell types in organ systems. The principal met ... Full text Link to item Cite

Sex Modifies Acute Ozone-Mediated Airway Physiologic Responses.

Journal Article Toxicol Sci · June 1, 2019 Sex differences clearly exist in incidence, susceptibility, and severity of airway disease and in pulmonary responses to air pollutants such as ozone (O3). Prior rodent O3 exposure studies demonstrate sex-related differences in the expression of lung infla ... Full text Link to item Cite

Hyaluronan interactions with innate immunity in lung biology.

Journal Article Matrix Biol · May 2019 Lung disease is a leading cause of morbidity and mortality worldwide. Innate immune responses in the lung play a central role in the pathogenesis of lung disease and the maintenance of lung health, and thus it is crucial to understand factors that regulate ... Full text Link to item Cite

Immediate Release of Gastrin-Releasing Peptide Mediates Delayed Radiation-Induced Pulmonary Fibrosis.

Journal Article Am J Pathol · May 2019 Radiation-induced pulmonary fibrosis (RTPF) is a progressive, serious condition in many subjects treated for thoracic malignancies or after accidental nuclear exposure. No biomarker exists for identifying the irradiated subjects most susceptible to pulmona ... Full text Link to item Cite

Delayed Increases in Hyaluronan Following Ozone Exposure Associates with Alveolar Type 2 Cell Proliferation

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2019 Link to item Cite

The Role of IRAK-M in Regulating Innate Immune Responses Following Acute Ozone Exposure

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2019 Link to item Cite

Silica Exposure Differentially Modulates Autoimmunity in Lupus Strains and Autoantibody Transgenic Mice.

Journal Article Front Immunol · 2019 Inhalational exposure to crystalline silica is linked to several debilitating systemic autoimmune diseases characterized by a prominent humoral immune component, but the mechanisms by which silica induces autoantibodies is poorly understood. To better unde ... Full text Link to item Cite

Euthanasia- and Lavage-mediated Effects on Bronchoalveolar Measures of Lung Injury and Inflammation.

Journal Article Am J Respir Cell Mol Biol · August 2018 Accurate and reproducible assessments of experimental lung injury and inflammation are critical for basic and translational research. In particular, investigators use various methods for BAL and euthanasia; however, the impact of these methods on assessmen ... Full text Link to item Cite

Specialized Pro-Resolving Lipid Mediators Regulate Ozone-Induced Pulmonary and Systemic Inflammation.

Journal Article Toxicol Sci · June 1, 2018 Exposure to ozone (O3) induces lung injury, pulmonary inflammation, and alters lipid metabolism. During tissue inflammation, specialized pro-resolving lipid mediators (SPMs) facilitate the resolution of inflammation. SPMs regulate the pulmonary immune resp ... Full text Link to item Cite

Effect of the S-nitrosoglutathione reductase inhibitor N6022 on bronchial hyperreactivity in asthma.

Journal Article Immun Inflamm Dis · June 2018 RATIONALE: Patients with asthma demonstrate depletion of the endogenous bronchodilator GSNO and upregulation of GSNOR. OBJECTIVES: An exploratory proof of concept clinical study of N6022 in mild asthma to determine the potential bronchoprotective effects o ... Full text Link to item Cite

Flow Cytometry for the Immunotoxicologist.

Journal Article Methods Mol Biol · 2018 Assessing the immunotoxicity of xenobiotics by current regulatory testing has revealed compounds that can cause immunosuppression and stimulation. Flow cytometry is a cutting edge technique that can provide data on how toxicants can alter the quality and q ... Full text Link to item Cite

Isolation and Characterization of Human Lung Myeloid Cells.

Journal Article Methods Mol Biol · 2018 Multiparameter flow cytometry of human lungs allows for characterization, isolation, and examination of human pulmonary immune cell composition, phenotype, and function. Here we describe an approach to process lung tissues and then utilize a base antibody ... Full text Link to item Cite

Longitudinal Follow Up After Xe-129 MRI Scan; Potential to Stratify Idiopathic Pulmonary Fibrosis Disease Progression

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2018 Link to item Cite

Characterization of Paraoxonases in Mice with Obese Allergic Asthma

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2018 Link to item Cite

Vertical Sleeve Gastrectomy in Allergen-Challenged Obese Mice Is Associated with Reduced Airway Resistance and Fibrosis

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2018 Link to item Cite

CD163 Protects Against Ozone Increased Susceptibility to Bacterial Pneumonia

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2018 Link to item Cite

Genetic Variation in Surfactant Protein-A2 Differentially Mediates Responses to Ozone

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2018 Link to item Cite

Alveolar Macrophages Contribute to the Type 2 Alveolar Epithelial Stem Cell Niche

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2018 Link to item Cite

Arginase1 Deficiency in Monocytes/Macrophages Upregulates Inducible Nitric Oxide Synthase To Promote Cutaneous Contact Hypersensitivity.

Journal Article J Immunol · September 1, 2017 The innate immune components that modulate allergic contact hypersensitivity (CHS) responses are poorly defined. Using human skin from contact dermatitis patients and a mouse model of CHS, we find that hapten allergens disrupt the Arginase1 (Arg1) and indu ... Full text Link to item Cite

A novel role for primary cilia in airway remodeling.

Journal Article Am J Physiol Lung Cell Mol Physiol · August 1, 2017 Primary cilia (PC) are solitary cellular organelles that play critical roles in development, homeostasis, and disease pathogenesis by modulating key signaling pathways such as Sonic Hedgehog and calcium flux. The antenna-like shape of PC enables them also ... Full text Open Access Link to item Cite

Characteristics Of Interstitial Lung Disease In The Mid-Atlantic Veterans Affairs Regional Network

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2017 Link to item Cite

Tlr5 Protects From The Development Of Pulmonary Fibrosis

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2017 Link to item Cite

Ozone primes alveolar macrophage-derived innate immunity in healthy human subjects.

Journal Article J Allergy Clin Immunol · October 2016 The present study demonstrates that acute ozone exposure of healthy human subjects enhances lung immune responses to subsequent bacterial stimuli. This highlights common air pollutant exposures as modifiers of the intensity of pulmonary immune activation. ... Full text Link to item Cite

Flow Cytometric Analysis of Myeloid Cells in Human Blood, Bronchoalveolar Lavage, and Lung Tissues.

Journal Article Am J Respir Cell Mol Biol · January 2016 Clear identification of specific cell populations by flow cytometry is important to understand functional roles. A well-defined flow cytometry panel for myeloid cells in human bronchoalveolar lavage (BAL) and lung tissue is currently lacking. The objective ... Full text Link to item Cite

Full Spectrum of LPS Activation in Alveolar Macrophages of Healthy Volunteers by Whole Transcriptomic Profiling.

Journal Article PLoS One · 2016 Despite recent advances in understanding macrophage activation, little is known regarding how human alveolar macrophages in health calibrate its transcriptional response to canonical TLR4 activation. In this study, we examined the full spectrum of LPS acti ... Full text Link to item Cite

Marco Regulates The In Vivo Response To Low Molecular Weight Hyaluronan Fragments

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2016 Link to item Cite

Rapid Onset Of Ozone-Induced Pulmonary Fibrosis In Diabetic Kkay Mice

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2016 Link to item Cite

Flow Cytometry Of Human Bronchoalveolar Lavage Fluid And Lung Tissue Identifies Interstitial Macrophages

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2015 Link to item Cite

Ifn-Gamma And Cxcr3 Axis Is Important To Ozone-Induced Pathobiology

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2015 Link to item Cite

Cx3cr1 Regulates The Early Neutrophil Response To Intrapulmonary Infection With Klebsiella Pneumoniae

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2015 Link to item Cite

Air Pollution and Immune Function

Chapter · January 1, 2015 Air pollution has clear impacts on human health and is associated with both cardiopulmonary complications as well as exacerbating chronic disease. As a principal site of exposure to air pollution, the lung is central to the health effects of air pollution. ... Full text Cite

Identification of myeloid cell subsets in murine lungs using flow cytometry.

Journal Article Am J Respir Cell Mol Biol · August 2013 Although the antibody-based recognition of cell-surface markers has been widely used for the identification of immune cells, overlap in the expression of markers by different cell types and the inconsistent use of antibody panels have resulted in a lack of ... Full text Link to item Cite

Genes of innate immunity and the biological response to inhaled ozone.

Journal Article J Biochem Mol Toxicol · January 2013 Ambient ozone has a significant impact on human health. We have made considerable progress in understanding the fundamental mechanisms that regulate the biological response to ozone. It is increasingly clear that genes of innate immunity play a central rol ... Full text Link to item Cite

A macrophage subpopulation recruited by CC chemokine ligand-2 clears apoptotic cells in noninfectious lung injury.

Journal Article Am J Physiol Lung Cell Mol Physiol · May 1, 2012 CC chemokine ligand-2 (CCL2)/monocyte chemoattractant protein (MCP)-1 expression is upregulated during pulmonary inflammation, and the CCL2-CCR2 axis plays a critical role in leukocyte recruitment and promotion of host defense against infection. The role o ... Full text Link to item Cite

The opprobrium of Big Tobacco.

Journal Article Am J Respir Crit Care Med · May 1, 2012 Full text Link to item Cite

RETRACTED: NAD(P)H:quinone oxidoreductase 1 protects lungs from oxidant-induced emphysema in mice.

Journal Article Free Radic Biol Med · February 1, 2012 This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our-business/policies/article-withdrawal). This article has been retracted at the request of the Authors. Since learning of potential discrepa ... Full text Link to item Cite

Ozone inhalation promotes CX3CR1-dependent maturation of resident lung macrophages that limit oxidative stress and inflammation.

Journal Article J Immunol · November 1, 2011 Inhalation of ambient ozone alters populations of lung macrophages. However, the impact of altered lung macrophage populations on the pathobiology of ozone is poorly understood. We hypothesized that subpopulations of macrophages modulate the response to oz ... Full text Link to item Cite

Recruited exudative macrophages selectively produce CXCL10 after noninfectious lung injury.

Journal Article Am J Respir Cell Mol Biol · October 2011 The chemokine, CXCL10, and its cognate receptor, CXCR3, are important mediators of the pathobiology of lung fibrosis. Macrophages are a known source of CXCL10, but their specific source in the lung is poorly defined due to incomplete characterization of ma ... Full text Link to item Cite

Extracellular Matrix Protein Mindin is Required for the Complete Allergic Response to Fungal-Associated Proteinase.

Journal Article Journal of allergy & therapy · September 2011 Asthma remains an important cause of morbidity and mortality with an incidence that continues to rise. Despite the importance of this disease, the mechanisms by which the host develops allergic airways disease remain poorly understood. The development of a ... Full text Cite

Ambient ozone and pulmonary innate immunity.

Journal Article Immunol Res · April 2011 Ambient ozone is a criteria air pollutant that impacts both human morbidity and mortality. The effect of ozone inhalation includes both toxicity to lung tissue and alteration of the host immunologic response. The innate immune system facilitates immediate ... Full text Link to item Cite

Arginase-1 Expression in CXCR3 Knockout Mice Identifies Alternatively Activated Macrophages after Non-Infectious Lung Injury

Journal Article AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2009 Link to item Cite