Scholars@Duke
Victor Louis Roggli

Victor Louis Roggli

Professor of Pathology
Pathology
Roggl002@mc.duke.edu
Duke Box 3712, Durham, NC 27710
M255 Davison Bldg, 200 Trent Drive, Durham, NC 27710

Selected Publications

Guidelines for Pathologic Diagnosis of Mesothelioma: 2023 Update of the Consensus Statement From the International Mesothelioma Interest Group.

Journal Article Arch Pathol Lab Med · November 1, 2024 CONTEXT.—: Mesothelioma is an uncommon tumor that can be difficult to diagnose. OBJECTIVE.—: To provide updated, practical guidelines for the pathologic diagnosis of mesothelioma. DATA SOURCES.—: Pathologists involved in the International Mesothelioma Inte ... Full text Link to item Cite

The Interplay Between the Immune System, Tumor Suppressor Genes, and Immune Senescence in Mesothelioma Development and Response to Immunotherapy.

Journal Article J Thorac Oncol · April 2024 Despite efforts to ban asbestos mining and manufacturing, mesothelioma deaths in the United States have remained stable at approximately 2500 cases annually. This trend is not unique to the United States but is also a global phenomenon, associated with inc ... Full text Link to item Cite

The diagnosis of asbestosis in the 21st century: a clinicopathological correlation of 102 cases.

Journal Article Ultrastruct Pathol · March 3, 2024 Asbestosis, defined as diffuse pulmonary fibrosis caused by inhalation of asbestos fibers, occurs after heavy exposures to asbestos dust over several decades. Because workplace exposures have been significantly curtailed since the banning of asbestos in in ... Full text Link to item Cite

Mesothelioma in the pleura, pericardium and peritoneum: Recommendations from the International Collaboration on Cancer Reporting (ICCR).

Journal Article Histopathology · March 2024 AIMS: Mesothelioma is a rare malignancy of the serosal membranes that is commonly related to exposure to asbestos. Despite extensive research and clinical trials, prognosis to date remains poor. Consistent, comprehensive and reproducible pathology reportin ... Full text Link to item Cite

The over diagnosis of diffuse mesothelioma: An analysis of 311 cases with recommendations for the avoidance of pitfalls.

Journal Article Ann Diagn Pathol · February 2024 BACKGROUND: The diagnosis of mesothelioma may be challenging. We investigated a large database of cases in order to determine the frequency with which a diagnosis of mesothelioma was made incorrectly and the most frequent causes of error. DESIGN: A databas ... Full text Link to item Cite

Diagnostic Approach to Pulmonary B-Cell Lymphomas in Small Biopsies, with Practical Recommendations to Avoid Misinterpretation.

Journal Article Diagnostics (Basel) · October 26, 2023 Pulmonary lymphomas are rare. With the current less invasive approaches used to obtain material for diagnosis, the diagnosis of pulmonary lymphoma is now frequently established in a small biopsy rather than in a resection. Therefore, the diagnosis has beco ... Full text Link to item Cite

Alveolar Mitochondrial Quality Control During Acute Respiratory Distress Syndrome.

Conference Lab Invest · September 2023 Acute respiratory distress syndrome (ARDS) is a leading cause of respiratory failure and death in patients in the intensive care unit. Experimentally, acute lung injury resolution depends on the repair of mitochondrial oxidant damage by the mitochondrial q ... Full text Link to item Cite

Asbestos and Iron.

Journal Article Int J Mol Sci · August 3, 2023 Theories of disease pathogenesis following asbestos exposure have focused on the participation of iron. After exposure, an open network of negatively charged functional groups on the fiber surface complexes host metals with a preference for iron. Competiti ... Full text Link to item Cite

Mechanisms and shapes of causal exposure-response functions for asbestos in mesotheliomas and lung cancers.

Journal Article Environ Res · August 1, 2023 This paper summarizes recent insights into causal biological mechanisms underlying the carcinogenicity of asbestos. It addresses their implications for the shapes of exposure-response curves and considers recent epidemiologic trends in malignant mesothelio ... Full text Link to item Cite

Mucus increases cell iron uptake to impact the release of pro-inflammatory mediators after particle exposure.

Journal Article Sci Rep · March 9, 2023 We tested the hypothesis that (1) mucus production can be included in the cell response to iron deficiency; (2) mucus binds iron and increases cell metal uptake; and subsequently (3) mucus impacts the inflammatory response to particle exposure. Using quant ... Full text Link to item Cite

Diagnostic approach to prevascular (anterior) mediastinal lymphomas: when thoracic pathology meets hematopathology.

Journal Article Mediastinum · 2023 Lymphomas are among the most common malignant tumors occurring in the anterior/prevascular mediastinum. Their diagnoses can be challenging in small biopsies, the current most common method of sampling of an anterior mediastinal mass. Because the initial cl ... Full text Link to item Cite

The 2021 WHO Classification of Tumors of the Pleura: Advances Since the 2015 Classification.

Journal Article Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer · May 2022 Substantial changes in the 2021 WHO Classification of Tumors of the Pleura and Pericardium since the 2015 WHO Classification include the following: (1) pleural and pericardial tumors have been combined in one chapter whereas in the 2015 WHO, pericardial tu ... Full text Cite

Cigarette Smoke Particle-Induced Lung Injury and Iron Homeostasis.

Journal Article Int J Chron Obstruct Pulmon Dis · 2022 It is proposed that the mechanistic basis for non-neoplastic lung injury with cigarette smoking is a disruption of iron homeostasis in cells after exposure to cigarette smoke particle (CSP). Following the complexation and sequestration of intracellular iro ... Full text Link to item Cite

Pneumoconioses

Chapter · January 1, 2022 This chapter discusses major forms of inhalational dust-related and occupational lung disease (pneumoconiosis). ... Full text Cite

Heparin-based blood purification attenuates organ injury in baboons with Streptococcus pneumoniae pneumonia.

Journal Article Am J Physiol Lung Cell Mol Physiol · August 1, 2021 Bacterial pneumonia is a major cause of morbidity and mortality worldwide despite the use of antibiotics, and novel therapies are urgently needed. Building on previous work, we aimed to 1) develop a baboon model of severe pneumococcal pneumonia and sepsis ... Full text Link to item Cite

Malignant Peritoneal Mesothelioma Arising in Young Adults With Long-standing Indwelling Intra-abdominal Shunt Catheters.

Journal Article Am J Surg Pathol · February 1, 2021 Only 50% to 70% of patients with mesothelioma report asbestos exposure. Other exposures (eg, radiation) play a role in some cases, but some patients have no obvious cause. We describe a series of patients with long-standing indwelling intra-abdominal shunt ... Full text Link to item Cite

Perls' Prussian Blue Stains of Lung Tissue, Bronchoalveolar Lavage, and Sputum.

Journal Article J Environ Pathol Toxicol Oncol · 2021 Perls' Prussian blue (PPB) stain recognizes Fe3+ associated with hemosiderin. The employment of this stain in clinical medicine and research has been extensive and novel applications continue to evolve. Ferruginous bodies are intracellular structures in lu ... Full text Link to item Cite

Case Report: Flavoring-Related Lung Disease in a Coffee Roasting and Packaging Facility Worker With Unique Lung Histopathology Compared With Previously Described Cases of Obliterative Bronchiolitis.

Journal Article Front Public Health · 2021 Occupational exposure to diacetyl, a butter flavor chemical, can result in obliterative bronchiolitis. Obliterative bronchiolitis is characterized by exertional dyspnea, fixed airflow obstruction, and histopathologic constrictive bronchiolitis, with bronch ... Full text Link to item Cite

Diacetyl exposure disrupts iron homeostasis in animals and cells.

Journal Article Inhal Toxicol · 2021 OBJECTIVE: Several mechanisms have been proposed for the biological effect of diacetyl. We tested the postulate that animal and cell exposures to diacetyl are associated with a disruption in iron homeostasis. MATERIALS AND METHODS: Male, Sprague-Dawley rat ... Full text Link to item Cite

Comprehensive Molecular and Pathologic Evaluation of Transitional Mesothelioma Assisted by Deep Learning Approach: A Multi-Institutional Study of the International Mesothelioma Panel from the MESOPATH Reference Center.

Journal Article J Thorac Oncol · June 2020 INTRODUCTION: Histologic subtypes of malignant pleural mesothelioma are a major prognostic indicator and decision denominator for all therapeutic strategies. In an ambiguous case, a rare transitional mesothelioma (TM) pattern may be diagnosed by pathologis ... Full text Link to item Cite

Talc and mesothelioma: mineral fiber analysis of 65 cases with clinicopathological correlation.

Journal Article Ultrastruct Pathol · March 3, 2020 Malignant mesothelioma is strongly associated with prior asbestos exposure. Recently there has been interest in the role of talc exposure in the pathogenesis of mesothelioma. We have analyzed lung tissue samples from a large series of malignant mesotheliom ... Full text Link to item Cite

Malignant Diffuse Mesothelioma in Women: A Study of 354 Cases.

Journal Article Am J Surg Pathol · March 2020 We reviewed 354 cases of malignant diffuse mesothelioma (MM) in women from a database of 2858 histologically confirmed MM cases. There was a pleural predominance with 78% pleural MM and 22% peritoneal MM. The pleural tumors consisted of 72% epithelioid, 19 ... Full text Link to item Cite

Interobserver variation in the assessment of the sarcomatoid and transitional components in biphasic mesotheliomas.

Journal Article Mod Pathol · February 2020 The percentage of sarcomatoid component has an impact on prognosis in patients with biphasic malignant pleural mesothelioma. Recent study showed that the transitional pattern similar to sarcomatoid component of malignant mesothelioma has negative prognosti ... Full text Link to item Cite

Chrysotile fibers in tissue adjacent to laryngeal squamous cell carcinoma in cases with a history of occupational asbestos exposure.

Journal Article Mod Pathol · February 2020 Asbestos describes a group of naturally occurring fibrous silicate mineral compounds that have been associated with a number of respiratory maladies, including mesothelioma and lung cancer. In addition, based primarily on epidemiologic studies, asbestos ha ... Full text Link to item Cite

Localized malignant mesothelioma, an unusual and poorly characterized neoplasm of serosal origin: best current evidence from the literature and the International Mesothelioma Panel.

Journal Article Mod Pathol · February 2020 Localized malignant mesotheliomas (LMM) is an uncommon and poorly recognized neoplasm. Its pathologic diagnosis is often surprising in patients with serosal/subserosal based localized tumors that are clinically suspicious for metastatic lesions or primary ... Full text Link to item Cite

Molecular Analysis of a Patient With Neurofibromatosis 2 (NF2) and Peritoneal Malignant Mesothelioma.

Journal Article Am J Surg Pathol · February 2020 Neurofibromatosis type 2 (NF2), an inherited disorder associated with multiple inherited schwannomas, meningiomas and ependymomas is caused by an autosomal dominant, likely loss of function germline mutation of the NF2 gene. Interestingly, biallelic NF2 ge ... Full text Link to item Cite

EURACAN/IASLC Proposals for Updating the Histologic Classification of Pleural Mesothelioma: Towards a More Multidisciplinary Approach.

Journal Article J Thorac Oncol · January 2020 INTRODUCTION: Molecular and immunologic breakthroughs are transforming the management of thoracic cancer, although advances have not been as marked for malignant pleural mesothelioma where pathologic diagnosis has been essentially limited to three histolog ... Full text Link to item Cite

Lung cancer: Clinical findings, pathology, and exposure assessment

Chapter · January 1, 2020 Lung cancer is the most common malignancy worldwide and the most common cause of a cancer-related death. Tobacco smoking is the most important cause of lung cancer in most populations although occupational exposures cause an increased risk of lung cancer m ... Full text Cite

Mesothelioma of the tunica vaginalis testis.

Journal Article Hum Pathol · October 2019 Malignant mesothelioma (MM) arising from the serosal membranes of the tunica vaginalis testis (TVT) is rare. Most examples in the published medical literature are individual case reports. This study presents the clinicopathological findings of mesothelioma ... Full text Link to item Cite

Dimensions of elongated mineral particles: a study of more than 570 fibers from more than 90 cases with implications for pathogenicity and classification as asbestiform vs. cleavage fragments.

Journal Article Ultrastruct Pathol · 2019 Asbestos is well-recognized as the cause of a variety of disorders of the respiratory tract, including neoplastic as well as non-neoplastic conditions. Fiber dimensions and biopersistence are important determinants of the pathologic response, and analytica ... Full text Link to item Cite

Dusting off the numbers of in situ particle analysis: a 35-year experience.

Journal Article Ultrastruct Pathol · 2019 A variety of fibrotic lung diseases are caused by the inhalation of organic dusts. Many of these disorders have distinctive histopathology and can be readily diagnosed by routine histopathologic examination. However, in some instances, there is overlap in ... Full text Link to item Cite

Silica Exposure Differentially Modulates Autoimmunity in Lupus Strains and Autoantibody Transgenic Mice.

Journal Article Front Immunol · 2019 Inhalational exposure to crystalline silica is linked to several debilitating systemic autoimmune diseases characterized by a prominent humoral immune component, but the mechanisms by which silica induces autoantibodies is poorly understood. To better unde ... Full text Link to item Cite

Measuring EMPs in the lung what can be measured in the lung: Asbestiform minerals and cleavage fragments.

Journal Article Toxicol Appl Pharmacol · December 15, 2018 Asbestos mineral fibers have been associated with the development of a variety of diseases in humans and experimental animals, including asbestosis, lung cancer, and mesothelioma. Asbestos includes several mineral types divided into two mineral groups, ser ... Full text Link to item Cite

Malignant peritoneal mesothelioma in patients with endometriosis.

Journal Article J Clin Pathol · November 2018 AIMS: Florid mesothelial hyperplasia is known to result from endometriosis. Well-differentiated papillary mesothelioma and multiloculated peritoneal inclusion cysts have also been described in women with endometriosis. To our knowledge, peritoneal diffuse ... Full text Link to item Cite

Malignant mesothelioma diagnosed at a younger age is associated with heavier asbestos exposure.

Journal Article Carcinogenesis · September 21, 2018 Asbestos exposure is the main etiology of malignant mesothelioma, but there are conflicting data on whether the intensity of exposure modulates the development of this disease. This study considered 594 patients with malignant mesothelioma for whom count d ... Full text Link to item Cite

Pleural nodular mesothelial/histiocytic hyperplasia associated with syphilis

Journal Article Human Pathology: Case Reports · September 1, 2018 Nodular mesothelial/histiocytic hyperplasia (NMHH) is a benign reactive phenomenon that can occur at any mesothelial site. We report the case of a 33 year old male who presented with chest pain and a pleural effusion, and after several months of investigat ... Full text Cite

New Insights on Diagnostic Reproducibility of Biphasic Mesotheliomas: A Multi-Institutional Evaluation by the International Mesothelioma Panel From the MESOPATH Reference Center.

Journal Article J Thorac Oncol · August 2018 INTRODUCTION: The 2015 WHO classification of tumors categorized malignant mesothelioma into epithelioid, biphasic (BMM), and sarcomatoid (SMM) for prognostic relevance and treatment decisions. The survival of BMM is suspected to correlate with the amount o ... Full text Link to item Cite

Asbestos Fiber Concentrations in the Lungs of Brake Repair Workers: An Updated Analysis Using Several Regression Methods to Handle Nondetectable Measurements.

Journal Article J Occup Environ Med · July 2018 OBJECTIVES: The aim of the study was to reanalyze an updated database of lung asbestos fiber levels for 21 brake repair workers who died of mesothelioma using robust maximum likelihood-based regression methods to address nondetectable measurements. METHODS ... Full text Link to item Cite

Malignant Mesothelioma and Its Non-Asbestos Causes.

Journal Article Arch Pathol Lab Med · June 2018 CONTEXT: - Although many mesotheliomas are related to asbestos exposure, not all are, and there is increasing information on other causes of mesothelioma. OBJECTIVE: - To provide a review of non-asbestos causes for malignant mesothelioma. DATA SOURCES: - R ... Full text Link to item Cite

Malignant Mesothelioma in Individuals With Nonmesothelial Neoplasms.

Journal Article Arch Pathol Lab Med · June 2018 CONTEXT: - Malignant mesothelioma (MM) is a component of the BAP1 tumor predisposition syndrome. Other than in BAP1 familial studies, nonmesothelial neoplasms in individuals with MM has not been comprehensively assessed. OBJECTIVE: - To assess the spectrum ... Full text Link to item Cite

Nuclear grade and necrosis predict prognosis in malignant epithelioid pleural mesothelioma: a multi-institutional study.

Journal Article Mod Pathol · April 2018 A recently described nuclear grading system predicted survival in patients with epithelioid malignant pleural mesothelioma. The current study was undertaken to validate the grading system and to identify additional prognostic factors. We analyzed cases of ... Full text Link to item Cite

Guidelines for Pathologic Diagnosis of Malignant Mesothelioma 2017 Update of the Consensus Statement From the International Mesothelioma Interest Group.

Journal Article Arch Pathol Lab Med · January 2018 CONTEXT: - Malignant mesothelioma (MM) is an uncommon tumor that can be difficult to diagnose. OBJECTIVE: - To provide updated, practical guidelines for the pathologic diagnosis of MM. DATA SOURCES: - Pathologists involved in the International Mesothelioma ... Full text Link to item Cite

Severe Pneumococcal Pneumonia Causes Cardiac and Skeletal Muscle Injuries in Baboons

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2018 Link to item Cite

Flavoring-Related Lung Disease in a Worker at a Coffee Roasting and Packaging Facility

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2018 Link to item Cite

Occupations With Exposure to Crystalline Silica

Chapter · January 1, 2018 This chapter discusses major forms of inhalational dust-related and occupational lung disease (pneumoconiosis). ... Full text Cite

Pneumoconioses

Chapter · October 20, 2017 This chapter discusses major forms of inhalational dust-related and occupational lung disease (pneumoconiosis). ... Full text Cite

The differential diagnosis between pleural sarcomatoid mesothelioma and spindle cell/pleomorphic (sarcomatoid) carcinomas of the lung: evidence-based guidelines from the International Mesothelioma Panel and the MESOPATH National Reference Center.

Journal Article Hum Pathol · September 2017 Immunohistochemistry is used to distinguish sarcomatoid malignant mesotheliomas (SMM) from spindle cell and pleomorphic carcinomas (SPC) but there are no guidelines on how to interpret cases that show overlapping or equivocal immunohistochemical findings. ... Full text Link to item Cite

Ocular Argyrosis Mimicking Conjunctival Melanoma.

Journal Article Cornea · June 2017 PURPOSE: To present a novel case of ocular argyrosis mimicking conjunctival melanoma. METHODS: A 48-year-old man who is a jewelry manufacturer presented with raised pigmented lesions in the inferior fornices of both eyes. Brown-black colored, follicle-like ... Full text Link to item Cite

Malignant peritoneal mesothelioma and Crohn disease.

Journal Article J Clin Pathol · March 2017 AIMS: Mesothelial reaction simulating peritoneal diffuse malignant mesothelioma (MM) has been reported in the setting of Crohn ileitis. To our knowledge, peritoneal MM arising in patients with inflammatory bowel disease (IBD) has not been reported. The pur ... Full text Link to item Cite

Non-Mesothelial Neoplasms in Individuals with Malignant Mesothelioma

Conference LABORATORY INVESTIGATION · February 1, 2017 Link to item Cite

Microprobe analysis in pulmonary pathology.

Journal Article Ultrastruct Pathol · January 2017 Full text Link to item Cite

Towards a general model for predicting the toxicity and pathogenicity of mineral fibres

Conference European Mineralogical Union Notes in Mineralogy · January 1, 2017 This chapter provides a comprehensive description of the physical, chemical, biological and mineralogical parameters that play a role in determining the toxicity and pathogenicity of mineral fibres. The first steps towards a general toxicity/pathogenicity ... Full text Cite

Mesothelioma Pathology

Chapter · 2017 Cite

Dataset for Reporting of Malignant Mesothelioma of the Pleura or Peritoneum: Recommendations From the International Collaboration on Cancer Reporting (ICCR).

Journal Article Arch Pathol Lab Med · October 2016 CONTEXT: -The International Collaboration on Cancer Reporting is a not-for-profit organization formed by the Royal Colleges of Pathologists of Australasia and the United Kingdom; the College of American Pathologists; the Canadian Association of Pathologist ... Full text Link to item Cite

Diffuse malignant mesothelioma and synchronous lung cancer: A clinicopathological study of 18 cases.

Journal Article Lung Cancer · May 2016 OBJECTIVES: To examine the clinicopathologic characteristics of individuals with diffuse malignant mesothelioma (DMM) occurring concurrently with lung cancer (LC). MATERIALS AND METHODS: A database of approximately 3800 patients with DMM was reviewed, from ... Full text Link to item Cite

Giant cell interstitial pneumonia in patients without hard metal exposure: analysis of 3 cases and review of the literature.

Journal Article Hum Pathol · April 2016 Giant cell interstitial pneumonia is a rare lung disease and is considered pathognomonic for hard metal lung disease, although some cases with no apparent hard metal (tungsten carbide cobalt) exposure have been reported. We aimed to explore the association ... Full text Link to item Cite

The 2015 World Health Organization Classification of Tumors of the Pleura: Advances since the 2004 Classification.

Journal Article J Thorac Oncol · February 2016 A new World Health Organization (WHO) Classification of Tumors of the Pleura has recently been published. While the histologic classification of pleural malignant mesothelioma remains the same in the 2015 WHO classification as it was in the 2004 classifica ... Full text Link to item Cite

A hard (metal) case: Value of analytical scanning electron microscopy.

Journal Article Ultrastruct Pathol · 2016 Exposure to hard metal (tungsten carbide) dust is a rare cause of interstitial lung disease. Although most cases have a distinctive morphology known as giant cell interstitial pneumonitis, other patterns have been described as well. In such cases, the true ... Full text Link to item Cite

Fiber analysis vignettes: Electron microscopy to the rescue!

Journal Article Ultrastruct Pathol · 2016 There has been considerable interest in the exposure doses that contribute to the various asbestos-associated diseases. Epidemiological studies have shown important differences in the contributions of the various fiber types to asbestos-related diseases, w ... Full text Link to item Cite

Aluminum-induced pneumoconiosis confirmed by analytical scanning electron microscopy: A case report and review of the literature.

Journal Article Ultrastruct Pathol · 2016 Aluminum-induced lung injury is an uncommon, yet recognized pneumoconiosis capable of causing severe interstitial fibrosis. Important attention to the clinical history including occupational exposure is an essential component to making the correct diagnosi ... Full text Link to item Cite

Carcinoma of the lung in the absence of asbestosis: The value of lung fiber burden analysis.

Journal Article Ultrastruct Pathol · 2016 Asbestos is universally recognized as a carcinogen for the lower respiratory tract. However, asbestos is a contributory factor in a small fraction of lung cancers, the vast majority of which are related to cigarette smoking. The challenge for the pathologi ... Full text Link to item Cite

Malignant mesothelioma not related to asbestos exposure: Analytical scanning electron microscopic analysis of 83 cases and comparison with 442 asbestos-related cases.

Journal Article Ultrastruct Pathol · 2016 Epidemiological studies indicate that 80-90% of mesotheliomas are asbestos related. This suggests that 10-20% are not. Lung fiber burden analysis provides objective information about past exposures to asbestos. We have performed lung fiber burden analysis ... Full text Link to item Cite

Asbestos content of lung tissue in patients with malignant peritoneal mesothelioma: A study of 42 cases.

Journal Article Ultrastruct Pathol · 2016 Lung tissue from 42 peritoneal mesothelioma cases was analyzed by light microscopy and scanning electron microscopy/energy dispersive spectrometry. There were 34 men and 8 women with a mean age of 61 ± 10 years. Also, 17% of cases had histologically confir ... Full text Link to item Cite

Endogenous pneumoconiosis: Analytical scanning electron microscopic analysis of a case.

Journal Article Ultrastruct Pathol · 2016 Pneumoconiosis is often considered a disease of the lung initiated by exposure to dust or other airborne particles, resulting in injury to the lungs. The term "endogenous pneumoconiosis" has been used in the literature to describe the deposition of compoun ... Full text Link to item Cite

Erionite-associated malignant pleural mesothelioma in Mexico

Journal Article International Journal of Clinical and Experimental Pathology · January 1, 2016 Malignant mesothelioma is a highly fatal cancer of the visceral and parietal pleura most often caused by asbestos exposure. However, studies over the past thirty-five to forty years have shown that a fibrous zeolite mineral found in the soil, erionite, is ... Cite

Sarcomatoid Peritoneal Mesothelioma

Journal Article American Journal of Surgical Pathology · December 2015 Full text Cite

Sarcomatoid Peritoneal Mesothelioma: Clinicopathologic Correlation of 13 Cases.

Conference Am J Surg Pathol · November 2015 Peritoneal mesothelioma is rare, and the sarcomatoid variant is more infrequent, with <30 cases reported to date in the literature. Several case series have described the morphologic features of sarcomatoid peritoneal mesothelioma (SPe); however, the clini ... Full text Link to item Cite

Effects of inhaled CO administration on acute lung injury in baboons with pneumococcal pneumonia.

Journal Article Am J Physiol Lung Cell Mol Physiol · October 15, 2015 Inhaled carbon monoxide (CO) gas has therapeutic potential for patients with acute respiratory distress syndrome if a safe, evidence-based dosing strategy and a ventilator-compatible CO delivery system can be developed. In this study, we used a clinically ... Full text Link to item Cite

Malignant (Diffuse) Mesothelioma in Patients With Hematologic Malignancies: A Clinicopathologic Study of 45 Cases.

Journal Article Arch Pathol Lab Med · September 2015 CONTEXT: Ionizing radiation has a role in the development of malignant mesothelioma, in several epidemiologic studies, including patients with hematologic malignancies. OBJECTIVE: To study the clinicopathologic characteristics of patients with malignant me ... Full text Link to item Cite

The So-called Short-Fiber Controversy: Literature Review and Critical Analysis.

Journal Article Arch Pathol Lab Med · August 2015 CONTEXT: Numerous articles in the scientific literature indicate that pathogenic fibers with respect to asbestos-related diseases are those that exceed 5 μm in length. Nonetheless, some authors have expressed concerns regarding pathogenicity of shorter fib ... Full text Link to item Cite

Immunostaining in lung cancer for the clinician. Commonly used markers for differentiating primary and metastatic pulmonary tumors.

Journal Article Ann Am Thorac Soc · March 2015 Immunohistochemical stains have become invaluable for the diagnosis of pulmonary malignancies (both primary and metastatic), particularly given the small size of transbronchial and endobronchial biopsies and the increasing need to conserve tissue for molec ... Full text Link to item Cite

Iron and Iron-Related Proteins in Asbestosis.

Journal Article J Environ Pathol Toxicol Oncol · 2015 We tested the postulate that iron homeostasis is altered among patients diagnosed to have asbestosis. Lung tissue from six individuals diagnosed to have had asbestosis at autopsy was stained for iron, ferritin, divalent metal transporter 1 (DMT1), and ferr ... Full text Link to item Cite

Reproducibility of histopathological diagnosis in poorly differentiated NSCLC: an international multiobserver study.

Journal Article J Thorac Oncol · September 2014 INTRODUCTION: The 2004 World Health Organization classification of lung cancer contained three major forms of non-small-cell lung cancer: squamous cell carcinoma (SqCC), adenocarcinoma (AdC), and large cell carcinoma. The goal of this study was first, to a ... Full text Link to item Cite

Development of a novel preclinical model of pneumococcal pneumonia in nonhuman primates.

Journal Article Am J Respir Cell Mol Biol · May 2014 Pneumococcal pneumonia is a leading cause of bacterial infection and death worldwide. Current diagnostic tests for detecting Streptococcus pneumoniae can be unreliable and can mislead clinical decision-making and treatment. To address this concern, we deve ... Full text Link to item Cite

Biological effects of desert dust in respiratory epithelial cells and a murine model.

Journal Article Inhal Toxicol · April 2014 As a result of the challenge of recent dust storms to public health, we tested the postulate that desert dust collected in the southwestern United States imparts a biological effect in respiratory epithelial cells and an animal model. Two samples of surfac ... Full text Link to item Cite

In vitro determinants of asbestos fiber toxicity: effect on the relative toxicity of Libby amphibole in primary human airway epithelial cells.

Journal Article Part Fibre Toxicol · January 8, 2014 BACKGROUND: An abnormally high incidence of lung disease has been observed in the residents of Libby, Montana, which has been attributed to occupational and environmental exposure to fibrous amphiboles originating from a nearby contaminated vermiculite min ... Full text Link to item Cite

Cumulative Retrospective Exposure Assessment (REA) as a predictor of amphibole asbestos lung burden: validation procedures and results for industrial hygiene and pathology estimates.

Journal Article Inhal Toxicol · January 2014 CONTEXT: A detailed evaluation of the correlation and linearity of industrial hygiene retrospective exposure assessment (REA) for cumulative asbestos exposure with asbestos lung burden analysis (LBA) has not been previously performed, but both methods are ... Full text Link to item Cite

Expanding the spectrum of particle-and fiber-associated interstitial lung diseases

Journal Article Turk Toraks Dergisi · January 1, 2014 While interstitial lung disease (ILD) is common, less than five percent of diagnoses appear to be related to occupational and environmental exposures to particles and fibers; these injuries are most frequently recognized as pneumoconioses and hypersensitiv ... Full text Cite

Lung cancer (exposure assessment, pathology, and epidemiology)

Chapter · January 1, 2014 Lung cancer is the most common malignancy worldwide and the most common cause of a cancer-related death. Tobacco smoking is the most important cause of lung cancer in most populations although occupational exposures cause an increased risk of lung cancer m ... Full text Cite

Analysis of tissue mineral fiber content

Chapter · January 1, 2014 The development of techniques for assaying the mineral fiber content of tissues has provided the opportunity to correlate the occurrence of various fiber-related diseases with the cumulative fiber burdens in the target organ. Exposure to mineral fibers gen ... Full text Cite

Asbestosis

Chapter · January 1, 2014 The term pneumoconiosis dates to Zenker’s 1866 description of pulmonary disease processes related to the inhalation of dusts [1]. As some dust, including asbestos fibers, may be found in the lungs of virtually all adults from the general population, pneumo ... Full text Cite

Pathology of asbestos-associated diseases, third edition

Book · January 1, 2014 The third edition of Pathology of Asbestos-Associated Diseases builds on the success of the previous editions by fully updating knowledge on diagnostic and epidemiologic aspects and presenting important new insights derived from new epidemiologic studies a ... Full text Cite

Asbestos bodies and non-asbestos ferruginous bodies

Chapter · January 1, 2014 The development of techniques for assaying the mineral fiber content of tissues has provided the opportunity to correlate the occurrence of various fiber-related diseases with the cumulative fiber burdens in the target organ. Exposure to mineral fibers gen ... Full text Cite

Carcinoma of the lung

Chapter · January 1, 2014 During the past 50 years, the USA and other industrialized nations have witnessed a remarkable increase in mortality from carcinoma of the lung. Today, this disease is the number one cause of cancer mortality in the USA, accounting for more than 180,000 de ... Full text Cite

Medicolegal Aspects of Asbestos I — Malignant Mesothelioma and Lung Cancer

Journal Article Academic Forensic Pathology · December 1, 2013 Inhalation of asbestos fibers can cause a variety of conditions, benign and malignant, of the lungs and pleura. Illnesses and deaths in which asbestos may have had a causal or contributory role are often the subject of litigation. Forensic pathologists (FP ... Full text Cite

Consideration of Occupational Lung Disease and Pneumoconiosis in Forensic Pathology

Journal Article Academic Forensic Pathology · December 1, 2013 Reports of workers stricken with lung disease sustained during the course of their employment date to antiquity. Despite stringent regulations to mitigate all manners of work place hazards, and the emergence of agencies and physicians engaged in the advanc ... Full text Cite

Iron accumulates in the lavage and explanted lungs of cystic fibrosis patients.

Journal Article J Cyst Fibros · July 2013 Oxidative stress participates in the pathophysiology of cystic fibrosis (CF). An underlying disruption in iron homeostasis can frequently be demonstrated in injuries and diseases associated with an oxidative stress. We tested the hypothesis that iron accum ... Full text Link to item Cite

Guidelines for pathologic diagnosis of malignant mesothelioma: 2012 update of the consensus statement from the International Mesothelioma Interest Group.

Journal Article Arch Pathol Lab Med · May 2013 CONTEXT: Malignant mesothelioma (MM) is an uncommon tumor that can be difficult to diagnose. OBJECTIVE: To provide updated practical guidelines for the pathologic diagnosis of MM. DATA SOURCES: Pathologists involved in the International Mesothelioma Intere ... Full text Link to item Cite

Diagnosis of lung adenocarcinoma in resected specimens: implications of the 2011 International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society classification.

Journal Article Arch Pathol Lab Med · May 2013 A new lung adenocarcinoma classification has been published by the International Association for the Study of Lung Cancer, the American Thoracic Society, and the European Respiratory Society. This new classification is needed to provide uniform terminology ... Full text Link to item Cite

Diagnosis of lung cancer in small biopsies and cytology: implications of the 2011 International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society classification.

Journal Article Arch Pathol Lab Med · May 2013 The new International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society lung adenocarcinoma classification provides, for the first time, standardized terminology for lung cancer diagnosis in small biopsies and ... Full text Link to item Cite

Reproducibility of histopathological subtypes and invasion in pulmonary adenocarcinoma. An international interobserver study.

Journal Article Mod Pathol · December 2012 Histological subtyping of pulmonary adenocarcinoma has recently been updated based on predominant pattern, but data on reproducibility are required for validation. This study first assesses reproducibility in subtyping adenocarcinomas and then assesses fur ... Full text Link to item Cite

Sclerosing hemangioma of the lung: Case report and literature review

Journal Article Pathology Case Reviews · September 1, 2012 ABSTRACT: Sclerosing hemangioma of lung is an unusual neoplasm with distinctive morphological features. Although its histogenesis has been debated for decades, the current concept is that this is a tumor of cells with features most closely resembling type ... Full text Cite

Biopersistence of refractory ceramic fiber in human lung tissue and a 20-year follow-up of radiographic pleural changes in workers.

Journal Article J Occup Environ Med · July 2012 OBJECTIVE: The biopersistence of refractory ceramic fiber (RCF) in human lung tissue is unknown and may contribute to an association between cumulative fiber exposure and radiographic changes. METHODS: Lung tissue fiber was analyzed for a case series of 10 ... Full text Link to item Cite

Indium lung disease.

Journal Article Chest · June 2012 BACKGROUND: Reports of pulmonary fibrosis, emphysema, and, more recently, pulmonary alveolar proteinosis (PAP) in indium workers suggested that workplace exposure to indium compounds caused several different lung diseases. METHODS: To better understand the ... Full text Link to item Cite

The opprobrium of Big Tobacco.

Journal Article Am J Respir Crit Care Med · May 1, 2012 Full text Link to item Cite

Occupational lung disease

Chapter · January 1, 2012 Introduction Occupational lung disease is the most significant form of work-related illness in the United States in terms of its severity, frequency and cost to society. The US Department of Labor reported the occurrence of some 4.1 million workplace injur ... Full text Cite

Disruption of iron homeostasis in mesothelial cells after talc pleurodesis.

Journal Article Am J Respir Cell Mol Biol · January 2012 The mechanism for biological effects after exposure to particles is incompletely understood. One postulate proposed to explain biological effects after exposure to particles involves altered iron homeostasis in the host. The fibro-inflammatory properties o ... Full text Link to item Cite

The fake fat phenomenon in organizing pleuritis: a source of confusion with desmoplastic malignant mesotheliomas.

Journal Article Am J Surg Pathol · December 2011 We report 9 patients with pleural biopsies referred because of concern about infiltration of what appeared to be chest wall fat by pan-keratin-positive spindled cells, a finding that led to a consideration of desmoplastic mesothelioma. All patients showed ... Full text Link to item Cite

Endobronchial metastatic breast cancer with pagetoid histology mimicking bronchial pagetoid squamous cell carcinoma in situ.

Journal Article Hum Pathol · November 2011 We report a case of a 56-year-old woman with endobronchial breast cancer metastasis of unusual histology. The patient presented with persistent cough, and a lesion was noted in the left mainstem bronchus on bronchoscopic examination. Biopsy revealed extens ... Full text Link to item Cite

Asbestos fiber concentrations in the lungs of brake repair workers: commercial amphiboles levels are predictive of chrysotile levels.

Journal Article Inhal Toxicol · October 2011 OBJECTIVES: To investigate the impact of extreme data points in Finkelstein's 2009 findings of no association between lung levels of commercial and non-commercial amphiboles (principally tremolite as a marker for chrysotile asbestos) in brake repair worker ... Full text Link to item Cite

From the authors

Journal Article American Journal of Respiratory and Critical Care Medicine · September 15, 2011 Full text Cite

International association for the study of lung cancer/american thoracic society/european respiratory society international multidisciplinary classification of lung adenocarcinoma.

Journal Article J Thorac Oncol · February 2011 INTRODUCTION: Adenocarcinoma is the most common histologic type of lung cancer. To address advances in oncology, molecular biology, pathology, radiology, and surgery of lung adenocarcinoma, an international multidisciplinary classification was sponsored by ... Full text Link to item Cite

Pneumoconioses

Chapter · January 1, 2011 Full text Cite

Pneumoconioses

Chapter · January 1, 2011 Full text Cite

Endobronchial metastatic breast cancer with pagetoid histology mimicking bronchial pagetoid squamous cell carcinoma in situ

Journal Article Human Pathology · January 1, 2011 We report a case of a 56-year-old woman with endobronchial breast cancer metastasis of unusual histology. The patient presented with persistent cough, and a lesion was noted in the left mainstem bronchus on bronchoscopic examination. Biopsy revealed extens ... Full text Cite

Effect of size fractionation on the toxicity of amosite and Libby amphibole asbestos.

Journal Article Toxicol Sci · December 2010 Abnormally high incidences of asbestos-related pulmonary disease have been reported in residents of Libby, Montana, because of occupational and environmental exposure to asbestos-contaminated vermiculite. The mechanism by which Libby amphibole (LA) causes ... Full text Link to item Cite

Small neuroendocrine lesions in intrathoracic lymph nodes of patients with primary lung adenocarcinoma: real metastasis?

Journal Article Am J Surg Pathol · November 2010 The presence of individual neuroendocrine cells in rare peripancreatic lymph nodes (LNs) suggests that neuroendocrine tumor or nested neuroendocrine cell proliferation can arise in situ from neuroendocrine cells native to any LN. However, it is very diffic ... Full text Link to item Cite

Pulmonary alveolar proteinosis in workers at an indium processing facility [2]

Journal Article American Journal of Respiratory and Critical Care Medicine · August 15, 2010 Full text Cite

Sarcomatoid mesothelioma: a clinical-pathologic correlation of 326 cases.

Journal Article Mod Pathol · March 2010 Sarcomatoid mesothelioma is the least common, but most aggressive of the three major histological types of mesotheliomas. This study comprises 326 cases of sarcomatoid mesotheliomas among 2000 consecutive malignant mesothelioma cases received in consultati ... Full text Link to item Cite

Pulmonary alveolar proteinosis in workers at an indium processing facility.

Journal Article Am J Respir Crit Care Med · March 1, 2010 Two cases of pulmonary alveolar proteinosis, including one death, occurred in workers at a facility producing indium-tin oxide (ITO), a compound used in recent years to make flat panel displays. Both workers were exposed to airborne ITO dust and had indium ... Full text Link to item Cite

Asbestos fiber content of lungs with diffuse interstitial fibrosis: An analytical scanning electron microscopic analysis of 249 cases.

Journal Article Arch Pathol Lab Med · March 2010 CONTEXT: Asbestosis is one of many forms of diffuse interstitial pulmonary fibrosis. Its histologic diagnosis rests on the pattern of fibrosis and the presence of asbestos bodies by light microscopy in lung biopsies. OBJECTIVE: To determine the asbestos fi ... Full text Link to item Cite

Pathology of asbestosis- An update of the diagnostic criteria: Report of the asbestosis committee of the college of american pathologists and pulmonary pathology society.

Journal Article Arch Pathol Lab Med · March 2010 UNLABELLED: Asbestosis is defined as diffuse pulmonary fibrosis caused by the inhalation of excessive amounts of asbestos fibers. Pathologically, both pulmonary fibrosis of a particular pattern and evidence of excess asbestos in the lungs must be present. ... Full text Link to item Cite

Pulmonary Alveolar Proteinosis In Indium-Exposed Workers

Journal Article AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2010 Link to item Cite

Pleural invasion

Journal Article JOURNAL OF THORACIC ONCOLOGY · September 1, 2009 Link to item Cite

Guidelines for pathologic diagnosis of malignant mesothelioma: a consensus statement from the International Mesothelioma Interest Group.

Journal Article Arch Pathol Lab Med · August 2009 CONTEXT: Malignant mesothelioma (MM) is an uncommon tumor that can be difficult to diagnose. OBJECTIVE: To develop practical guidelines for the pathologic diagnosis of MM. DATA SOURCES: A pathology panel was convened at the International Mesothelioma Inter ... Full text Link to item Cite

Pneumoconioses, mineral and vegetable

Journal Article · December 1, 2008 The term pneumoconiosis, originally coined by Zenker,1 literally means dust in the lung. Because various types of dust can be found in the lungs of virtually all adults, this term has come to mean the accumulation of abnormal amounts of dust in the lungs a ... Full text Cite

Pathology of small airways

Journal Article · December 1, 2008 The small conducting airways consist of the membranous bronchioles and the respiratory bronchioles. Bronchiolitis is a generic term for inflammatory and fibrotic injuries of these small airways. The histology of normal bronchioles is discussed in detail in ... Full text Cite

Emphysema and chronic bronchitis

Journal Article · December 1, 2008 The diagnosis of chronic obstructive pulmonary disease (COPD) is predicated upon the recognition of its two major forms: emphysema and chronic bronchitis. These distinct entities represent different manifestations of COPD, although they frequently coexist ... Full text Cite

Malignant mesothelioma with heterologous elements: clinicopathological correlation of 27 cases and literature review.

Journal Article Mod Pathol · September 2008 Only a small number of malignant mesotheliomas with heterologous elements have been described. There are currently no criteria for diagnosis and little data regarding prognosis. We suggest that the term heterologous mesothelioma should be reserved for tumo ... Full text Link to item Cite

The enemy within.

Journal Article Science · July 4, 2008 Full text Link to item Cite

Twenty-five years of fiber analysis: what have we learned?

Journal Article Hum Pathol · March 2008 Asbestos exposure has resulted in a variety of diseases, including asbestosis, carcinoma of the lung (LC), pleural plaques, and malignant mesothelioma (MM). We hypothesized that there have been significant changes in the mineral fiber content of lung tissu ... Full text Link to item Cite

Iron homeostasis and oxidative stress in idiopathic pulmonary alveolar proteinosis: a case-control study.

Journal Article Respir Res · January 23, 2008 BACKGROUND: Lung injury caused by both inhaled dusts and infectious agents depends on increased availability of iron and metal-catalyzed oxidative stress. Because inhaled particles, such as silica, and certain infections can cause secondary pulmonary alveo ... Full text Link to item Cite

Crocidolite and mesothelioma.

Journal Article Ultrastruct Pathol · 2008 This study reports changes in the frequency of detection of various asbestos fiber types between 1982 and 2005. Crocidolite is increasingly detected in U.S. mesothelioma patients. The percentage of crocidolite fibers detected in lung tissue has risen from ... Full text Link to item Cite

E01-02: State of the art mesothelioma diagnosis: a moving target

Journal Article Journal of Thoracic Oncology · August 2007 Full text Cite

Bronchioloalveolar carcinoma and lung adenocarcinoma: the clinical importance and research relevance of the 2004 World Health Organization pathologic criteria.

Journal Article J Thorac Oncol · November 2006 INTRODUCTION: Advances in the pathology and computed tomography (CT) of lung adenocarcinoma and bronchioloalveolar carcinoma (BAC) have demonstrated important new prognostic features that have led to changes in classification and diagnostic criteria. METHO ... Link to item Cite

Current treatment options and biology of peritoneal mesothelioma: meeting summary of the first NIH peritoneal mesothelioma conference.

Journal Article Ann Oncol · November 2006 Peritoneal mesothelioma is a rare cancer of the peritoneum with about 250 new cases diagnosed each year in the United States. It is the second most common site for mesothelioma development and accounts for 10-20% of all mesotheliomas diagnosed in the Unite ... Full text Link to item Cite

Physician subsidies for tobacco advertising.

Journal Article Am J Respir Crit Care Med · January 15, 2006 Full text Link to item Cite

Giant cell interstitial pneumonia associated with nitrofurantoin.

Journal Article Lung · 2006 A case of giant cell interstitial pneumonia (GIF) that occurred in association with exposure to nitrofurantoin is presented. While the diagnosis of GIP is confirmed by histopathology, this diagnosis can be supported by the findings of bizarre multinucleate ... Full text Link to item Cite

Pulmonary fibrosis and ferruginous bodies associated with exposure to synthetic fibers.

Journal Article Toxicol Pathol · 2006 Exposure to synthetic fibers with employment in textile mills can be associated with an elevated risk of interstitial lung disease (ILD). A mechanism of injury has not been determined. ILD can follow exposures to inorganic fibers (e.g., asbestos) which are ... Full text Link to item Cite

The role of analytical SEM in the determination of causation in malignant mesothelioma.

Journal Article Ultrastruct Pathol · 2006 The causative relationship between asbestos exposure and mesothelioma is firmly established. Some information in this regard comes from analysis of the fiber content of lung tissue by means of analytical electron microscopy. The author has had the opportun ... Full text Link to item Cite

Review and update of uncommon primary pleural tumors: a practical approach to diagnosis.

Journal Article Arch Pathol Lab Med · November 2005 OBJECTIVE: We address the current classifications and new changes regarding uncommon primary pleural tumors. Primary pleural tumors are divided according to their behavior and are discussed separately as benign tumors, tumors of low malignant potential, an ... Full text Link to item Cite

Localized malignant mesothelioma.

Journal Article Am J Surg Pathol · July 2005 Localized malignant mesotheliomas are uncommon sharply circumscribed tumors of the serosal membranes with the microscopic appearance of diffuse malignant mesothelioma but without any evidence of diffuse spread. Little is known about their behavior. We repo ... Full text Link to item Cite

Evolving concepts in the pathology and computed tomography imaging of lung adenocarcinoma and bronchioloalveolar carcinoma.

Journal Article J Clin Oncol · May 10, 2005 PURPOSE: To review recent advances in pathology and computed tomography (CT) of lung adenocarcinoma and bronchioloalveolar carcinoma (BAC). METHODS: A pathology/CT review panel of pathologists and radiologists met during a November 2004 International Assoc ... Full text Link to item Cite

Pulmonary embolization of microcrystalline cellulose in a lung transplant recipient.

Journal Article J Heart Lung Transplant · May 2005 Intravenous injection of drugs that contain insoluble foreign material can lead to pulmonary embolization of the material and can have devastating results, including pulmonary hypertension and death. Most cases are detected after the onset of extensive, ir ... Full text Link to item Cite

Comparison of monoclonal versus polyclonal calretinin antibodies for immunohistochemical diagnosis of malignant mesothelioma.

Journal Article Appl Immunohistochem Mol Morphol · March 2005 Of putative specific markers for diffuse malignant mesothelioma, nuclear staining with Zymed polyclonal calretinin antibody has shown the best specificity to date for epithelial diffuse malignant mesothelioma versus adenocarcinoma. We compared specificity ... Full text Link to item Cite

Mucinous (colloid) adenocarcinoma of the lung.

Journal Article Arch Pathol Lab Med · January 2005 Full text Link to item Cite

Proposed criteria for mixed-dust pneumoconiosis: definition, descriptions, and guidelines for pathologic diagnosis and clinical correlation.

Journal Article Hum Pathol · December 2004 We defined mixed-dust pneumoconiosis (MDP) pathologically as a pneumoconiosis showing dust macules or mixed-dust fibrotic nodules (MDF), with or without silicotic nodules (SN), in an individual with a history of exposure to mixed dust. We defined the latte ... Full text Link to item Cite

The spectrum of Kit (CD117) immunoreactivity in lung and pleural tumors: a study of 96 cases using a single-source antibody with a review of the literature.

Journal Article Arch Pathol Lab Med · May 2004 CONTEXT: The development of successful chemotherapeutic agents directed against the Kit receptor tyrosine kinase protein has generated intense interest in the Kit (CD117) immunoreactivity of various neoplasms. Immunoreactivity for Kit in small cell lung ca ... Full text Link to item Cite

Ferruginous bodies: implications in the mechanism of fiber and particle toxicity.

Journal Article Toxicol Pathol · 2004 Exposures to fibers and particles can be associated with several different lung injuries including bronchitis, bronchiolitis, pneumonitis, pleuritis, pulmonary alveolar proteinosis, pneumoconiosis, mesotheliomas, and lung cancers. The mechanism of biologic ... Full text Link to item Cite

Transforming growth factor alpha and epidermal growth factor receptor in reactive and malignant mesothelial proliferations.

Journal Article Arch Pathol Lab Med · January 2004 BACKGROUND: Growth factors such as transforming growth factor alpha (TGF-alpha) and epidermal growth factor receptor (EGFR) play an important role in cell proliferation. The immunohistochemical expression of these factors has been extensively studied in ma ... Full text Link to item Cite

Beryllium detection in human lung tissue using electron probe X-ray microanalysis.

Journal Article Mod Pathol · November 2003 Chronic berylliosis is an uncommon disease that is caused by the inhalation of beryllium particles, dust, or fumes. The distinction between chronic berylliosis and sarcoidosis can be difficult both clinically and histologically, as both entities can have s ... Full text Link to item Cite

The role of smoking and exposure to asbestos and man-made vitreous fibers in a questionable case of mesothelioma.

Journal Article Ind Health · October 2003 A remaining uncertainty in the U.S. cohort study of man-made vitreous fiber (MMVF) workers is whether asbestos exposure contributed to 10 questionable cases of mesothelioma. We report further details on one case from our previous mesothelioma investigation ... Full text Link to item Cite

Oxalate deposition on asbestos bodies.

Journal Article Hum Pathol · August 2003 We report on a deposition of oxalate crystals on ferruginous bodies after occupational exposure to asbestos demonstrated in 3 patients. We investigated the mechanism and possible significance of this deposition by testing the hypothesis that oxalate genera ... Full text Link to item Cite

Exposure to brake dust and malignant mesothelioma: a study of 10 cases with mineral fiber analyses.

Journal Article Ann Occup Hyg · June 2003 OBJECTIVES: A large number of workers in the USA are exposed to chrysotile asbestos through brake repair, yet only a few cases of malignant mesothelioma (MM) have been described in this population. Epidemiologic and industrial hygiene studies have failed t ... Full text Link to item Cite

Acute eosinophilic pneumonia in a New York City firefighter exposed to World Trade Center dust.

Journal Article Am J Respir Crit Care Med · September 15, 2002 We report a sentinel case of acute eosinophilic pneumonia in a firefighter exposed to high concentrations of World Trade Center dust during the rescue effort from September 11 to 24. The firefighter presented with a Pa(O2) of 53 mm Hg and responded to oxyg ... Full text Link to item Cite

Tremolite and mesothelioma.

Journal Article Ann Occup Hyg · July 2002 BACKGROUND: Exposure to chrysotile dust has been associated with the development of mesothelioma and recent studies have implicated contaminating tremolite fibers as the likely etiological factor. Tremolite also contaminates talc, the most common non-asbes ... Link to item Cite

Expression of telomerase reverse transcriptase (TERT) in malignant mesotheliomas.

Journal Article Am J Surg Pathol · March 2002 To evaluate the usefulness of determinations of telomerase activity for distinguishing malignant from benign mesothelial lesions, immunohistochemical (using a rabbit polyclonal antibody and the peroxidase method; n = 68) and in situ hybridization (using se ... Full text Link to item Cite

Malignant mesothelioma and occupational exposure to asbestos: An analysis of 1445 cases

Conference Annals of Occupational Hygiene · January 1, 2002 Asbestos exposure is indisputably associated with the development of malignant mesothelioma (MM). However, relatively few studies have correlated the manner of exposure with asbestos fiber content and type. We report findings from 1445 MMs with known expos ... Full text Cite

Malignant mesothelioma and occupational exposure to asbestos: a clinicopathological correlation of 1445 cases.

Journal Article Ultrastruct Pathol · 2002 Asbestos exposure is indisputably associated with development of mesothelioma. However, relatively few studies have evaluated the type of occupational exposure in correlation with asbestos fiber content and type. This study reports findings in 1445 cases o ... Full text Link to item Cite

Detection of beryllium in human lung tissue using energy dispersive X-ray analysis

Journal Article Microscopy and Microanalysis · January 1, 2002 Full text Cite

Outcome of lung transplant recipients: An autopsy study

Journal Article MODERN PATHOLOGY · January 1, 2002 Link to item Cite

Outcome of lung transplant recipients: An autopsy study

Journal Article LABORATORY INVESTIGATION · January 1, 2002 Link to item Cite

CD117 immunoreactivity in pleuropulmonary tumors

Journal Article LABORATORY INVESTIGATION · January 1, 2002 Link to item Cite

CD117 immunoreactivity in pleuropulmonary tumors

Journal Article MODERN PATHOLOGY · January 1, 2002 Link to item Cite

Diffuse alveolar damage after exposure to an oil fly ash.

Journal Article Am J Respir Crit Care Med · October 15, 2001 Epidemiological investigation has established an association between exposure to particulate matter (PM) and both human mortality and diverse indices of human morbidity. However, attributing adverse health effects of specific individuals to PM exposure in ... Full text Link to item Cite

Pulmonary apical cap.

Journal Article Am J Surg Pathol · October 2001 Full text Link to item Cite

Well-differentiated papillary mesothelioma.

Journal Article Am J Surg Pathol · October 2001 Well-differentiated papillary mesothelioma is an unusual variant of epithelial mesothelioma considered to be of low malignant potential. The majority of previously reported cases developed in the peritoneum of young women without a history of asbestos expo ... Full text Link to item Cite

Airway inflammation and responsiveness in prostaglandin H synthase-deficient mice exposed to bacterial lipopolysaccharide.

Journal Article Am J Respir Cell Mol Biol · October 2001 Bacterial lipopolysaccharide (LPS) is a risk factor for exacerbation of asthma and causes airway inflammation. The aim of this study was to examine the effects of disruption of prostaglandin (PG) H synthase (PGHS)-1 and PGHS-2 genes on pulmonary responses ... Full text Link to item Cite

CD34 positivity in pleural fibroblasts

Journal Article MODERN PATHOLOGY · January 1, 2001 Link to item Cite

CD34 positivity in pleural fibroblasts

Journal Article LABORATORY INVESTIGATION · January 1, 2001 Link to item Cite

Epithelioid hemangioendothelioma of the pleura: clinical and radiologic features.

Journal Article AJR Am J Roentgenol · December 2000 OBJECTIVE: The purpose of our study was to describe the clinical and radiologic features of epithelioid hemangioendothelioma of the pleura. CONCLUSION: Pleural epithelioid hemangioendothelioma is an uncommon malignancy that typically affects older men, who ... Full text Link to item Cite

Environmental malignant mesothelioma in southern Anatolia: a study of fifty cases.

Journal Article Environ Health Perspect · November 2000 Malignant mesothelioma is a highly aggressive tumor of the serous membranes, which in humans results from exposure to asbestos and asbestiform fibers. Although occupational malignant mesothelioma is still the most common form of this lesion, naturally cont ... Full text Link to item Cite

The separation of benign and malignant mesothelial proliferations.

Journal Article Am J Surg Pathol · September 2000 The separation of benign from malignant mesothelial proliferations has emerged as a major problem in the pathology of the serosal membranes. For both epithelial and spindle cell mesothelial processes, true stromal invasion is the most accurate indicator of ... Full text Link to item Cite

Calcium oxalate and iron accumulation in sarcoidosis.

Journal Article Sarcoidosis Vasc Diffuse Lung Dis · June 2000 BACKGROUND: In many patients with sarcoidosis, the granulomas contain inclusion bodies within giant cells. Many giant cells contain crystalline oxalate that chemically coordinates iron on the surface of the crystal. If this iron is incompletely coordinated ... Link to item Cite

Asbestos content of lung tissue and carcinoma of the lung: a clinicopathologic correlation and mineral fiber analysis of 234 cases.

Journal Article Ann Occup Hyg · March 2000 The aim of this study was to investigate the asbestos content of lung tissue in a series of patients with lung cancer and some history of asbestos exposure. This information was then correlated with demographic information, occupational and smoking history ... Link to item Cite

Solitary pulmonary nodules: Part I. Morphologic evaluation for differentiation of benign and malignant lesions.

Journal Article Radiographics · 2000 The solitary pulmonary nodule is a common radiologic abnormality that is often detected incidentally. Although most solitary pulmonary nodules have benign causes, many represent stage I lung cancers and must be distinguished from benign nodules in an exped ... Full text Link to item Cite

The pathology of interstitial lung disease in nylon flock workers.

Journal Article Am J Surg Pathol · December 1999 Flocking is a widely used industrial process in which short lengths of synthetic fibers are applied to backing fabric to produce plush material. In response to an apparent outbreak of interstitial lung disease in flock workers, the Centers for Disease Cont ... Full text Link to item Cite

Allergic lung responses are increased in prostaglandin H synthase-deficient mice.

Journal Article J Clin Invest · September 1999 To investigate the function of prostaglandin H synthase-1 and synthase-2 (PGHS-1 and PGHS-2) in the normal lung and in allergic lung responses, we examined allergen-induced pulmonary inflammation and airway hyperresponsiveness in wild-type mice and in PGHS ... Full text Link to item Cite

Pulmonary cholesterol granulomas in patients with pulmonary artery hypertension: chest radiographic and CT findings.

Journal Article AJR Am J Roentgenol · May 1999 OBJECTIVE: We describe the chest radiographic and CT findings of pulmonary cholesterol granulomas in patients with pulmonary artery hypertension. CONCLUSION: Histopathologic evidence of cholesterol granulomas was found in five (25%) of 20 patients with sev ... Full text Link to item Cite

Ultrastructural features of diffuse malignant mesotheliomas.

Journal Article Hum Pathol · December 1998 The distinction of malignant mesothelioma from tumors metastatic to the serosal membranes can often be made based on the results of histochemical or immunohistochemical studies. However, in some cases, these techniques are inadequate to make a firm diagnos ... Full text Link to item Cite

The diagnosis of desmoplastic malignant mesothelioma and its distinction from fibrous pleurisy: a histologic and immunohistochemical analysis of 31 cases including p53 immunostaining.

Journal Article Am J Clin Pathol · August 1998 We studied 31 patients with fibrotic pleural lesions and classified them as desmoplastic malignant mesothelioma (DMM) or fibrous pleurisy (FP) using predetermined histologic criteria, including a paucicellular fibrotic pleural lesion with a storiform patte ... Full text Link to item Cite

Silica-induced pleural disease: an unusual case mimicking malignant mesothelioma.

Journal Article Chest · November 5, 1997 A 57-year-old man with a history of exposure to silica for 32 years presented with pleural thickening of the lower lobe of the left lung and a chronic right-sided pleural effusion without any radiographic evidence of parenchymal nodules in either lung. Lig ... Full text Link to item Cite

Pleural macrophage recruitment and activation in asbestos-induced pleural injury.

Journal Article Environ Health Perspect · September 1997 The pathogenesis of asbestos-induced pleural fibrosis is poorly understood. Moreover, there has been a long-standing controversy regarding the relative potential of different commercial types of asbestos to cause pleural disease. We postulated that inhaled ... Full text Link to item Cite

Iron accumulation in lung allografts after transplantation.

Journal Article Chest · August 1997 Lung transplantation has become a therapeutic option for end-stage pulmonary diseases, but after transplantation, infections and obliterative bronchiolitis (OB) are major causes of long-term morbidity and mortality. OB is a fibroproliferative disease, of p ... Full text Link to item Cite

Prevalence of pulmonary atypical alveolar cell hyperplasia in an autopsy population: a study of 100 cases.

Journal Article Mod Pathol · May 1997 A precursor lesion of pulmonary adenocarcinoma has not been clearly defined. Previous studies suggested that atypical alveolar cell hyperplasia (AACH) might represent such a precursor lesion. Most previous studies showed an association between AACH and ade ... Link to item Cite

Effect of erionite on the pleural mesothelium of the Fischer 344 rat.

Journal Article Chest · May 1997 OBJECTIVE: This study sought to assess the fibrogenic and carcinogenic potential of erionite (a fibrous zeolite) on the pleural mesothelium of the Fischer 344 rat (n = 24). DESIGN: The study was designed to examine rat pleural mesothelial changes by three ... Full text Link to item Cite

In vivo accumulation of iron on crocidolite is associated with decrements in oxidant generation by the fiber.

Journal Article J Toxicol Environ Health · February 7, 1997 In vivo exposures to fibrous silicates are characterized by the formation of asbestos bodies. These structures consist of the original fiber with a coating of inexact composition, but it will include iron and protein. We tested the hypothesis that this iro ... Full text Link to item Cite

Malignant mesothelioma in women.

Journal Article Anat Pathol · 1997 About 8% of our cases of mesothelioma occur in women, with a median age of 59 years. Our percentage is lower than other series reported in the literature because of the large number of occupationally exposed men referred to our laboratory. Tumor arose in t ... Link to item Cite

Criteria for clinical diagnosis - Histological criteria

Conference PROCEEDINGS OF AN INTERNATIONAL EXPERT MEETING ON ASBESTOS, ASBESTOSIS AND CANCER · January 1, 1997 Link to item Cite

Pulmonary fibrogenesis after three consecutive inhalation exposures to chrysotile asbestos.

Journal Article Am J Respir Crit Care Med · November 1996 Previously, this laboratory developed a model of asbestos-induced pulmonary fibrogenesis in rats and mice after a brief (1 to 3-h) inhalation exposure. However, typical human environmental exposures would be repeated, although at lower concentrations than ... Full text Link to item Cite

Outbreak of bronchiolitis obliterans associated with consumption of Sauropus androgynus in Taiwan.

Journal Article Lancet · July 13, 1996 BACKGROUND: In August, 1995, there was an outbreak in Taiwan of rapidly progressive respiratory distress associated with consumption of uncooked Sauropus androgynus, a vegetable with a claimed yet unconfirmed effect on weight control. We report on 23 patie ... Full text Link to item Cite

Lipopolysaccharide up-regulates platelet-derived growth factor (PDGF) alpha-receptor expression in rat lung myofibroblasts and enhances response to all PDGF isoforms.

Journal Article J Immunol · June 15, 1996 Differential expression of PDGF receptor alpha and beta subunits controls the response of mesenchymal cells to the three PDGF isoforms (AA, AB, and BB). Cultured rat lung myofibroblasts (RLMF) possess abundant PDGF receptor-beta (PDGF-Rbeta) and little PDG ... Link to item Cite

p53 and MDM2 immunostaining in pulmonary blastomas and bronchogenic carcinomas.

Journal Article Hum Pathol · June 1996 Pulmonary blastomas (PBs) are rare primary malignancies that include adult types: biphasic pulmonary blastoma (BPB) and well-differentiated fetal adenocarcinoma (WDFA); and childhood type: pleuropulmonary blastoma (PPB). Their pathogenesis and relationship ... Full text Link to item Cite

Glutathione depletion in epithelial lining fluid of lung allograft patients.

Journal Article Am J Respir Crit Care Med · February 1996 The lower respiratory tract is protected against reactive oxygen species (ROS) by a complex antioxidant system. In the epithelial lining fluid (ELF), glutathione (L-alpha-glutamyl-L-cysteinylglycine, GSH) is essential for adequate protection of pneumocytes ... Full text Link to item Cite

Composition of lung lavage in pulmonary alveolar microlithiasis.

Journal Article Respiration · 1996 A case of pulmonary alveolar microlithiasis (PAM) is reported wherein total lung lavage was performed for relief of dyspnea. Characterization of the lavage material and examination of the microliths isolated from the lavage fluid confirmed previous reports ... Full text Link to item Cite

Accumulation of iron in the rat lung after intratracheal instillation of coal dust

Journal Article Applied Occupational and Environmental Hygiene · January 1, 1996 Inhalation of coal dust is associated with an accumulation of iron in the human lung. Collagen deposition in the lungs of coal miners can correlate with the concentration of tissue nonheme iron. Associations between the accumulation of this metal and fibro ... Full text Cite

Rare earth (cerium oxide) pneumoconiosis: analytical scanning electron microscopy and literature review.

Journal Article Mod Pathol · October 1995 Rare earth pneumoconiosis is an uncommonly reported disease caused by the inhalation of dust containing lanthanides, also known as rare earth metals, which are common industrial materials. The pathologic manifestations and natural history of this disorder ... Link to item Cite

A proposed new international TNM staging system for malignant pleural mesothelioma. From the International Mesothelioma Interest Group.

Journal Article Chest · October 1995 STUDY OBJECTIVE: Investigation of the behavior and treatment of the diffuse malignant pleural mesothelioma (MPM) is hindered by the lack of an accurate universally accepted staging system. To address this problem, the International Mesothelioma Interest Gr ... Full text Link to item Cite

Malignant mesothelioma associated with low pulmonary tissue asbestos burdens: a light and scanning electron microscopic analysis of 18 cases.

Journal Article Mod Pathol · August 1995 Most malignant mesothelioma cases are associated with pulmonary asbestos body (AB) counts significantly greater than those of the general population. However, the question remains whether malignant mesothelioma cases associated with "normal" AB counts (i.e ... Link to item Cite

Malignant mesothelioma and duration of asbestos exposure: correlation with tissue mineral fibre content.

Journal Article Ann Occup Hyg · June 1995 Among 441 cases of malignant mesothelioma in the author's files, there were 324 for whom reliable information was available regarding the duration of exposure to asbestos. Included were 298 pleural and 26 peritoneal mesotheliomas. The mean duration of expo ... Full text Link to item Cite

Recurrence of diffuse panbronchiolitis after lung transplantation.

Journal Article Am J Respir Crit Care Med · March 1995 Diffuse panbronchiolitis (DBP) is characterized by chronic inflammation of the upper and lower respiratory tract. DPB has been found almost exclusively in oriental populations. We describe the occurrence of a case of DPB in an African American patient who ... Full text Link to item Cite

Detection of silica particles in lung tissue by polarizing light microscopy.

Journal Article Arch Pathol Lab Med · March 1995 The detectability of silica particles in ordinary histologic sections by means of polarizing light microscopy has been controversial. Through the application of both correlative light microscopy and scanning electron microscopy to different lung sections, ... Link to item Cite

Curative resection of a well-differentiated papillary mesothelioma of the pericardium.

Journal Article Arch Pathol Lab Med · March 1995 A 27-year-old woman presented with fatigue and dyspnea and was found to have a 2 x 4-cm mass in the pericardium, which was resected. Histologic examination demonstrated a well-differentiated papillary mesothelioma of the pericardium. Postoperatively, she r ... Link to item Cite

RECURRENCE OF DIFFUSE PANBRONCHIOLITIS AFTER LUNG TRANSPLANTATION

Journal Article AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · March 1, 1995 Link to item Cite

Immunohistologic quantification of Pseudomonas aeruginosa in the tracheobronchial tree from patients with cystic fibrosis.

Journal Article Pediatr Pathol Lab Med · 1995 Pseudomonas aeruginosa has been recognized as a pathogen of major importance in the patient with cystic fibrosis (CF). However, no information is available regarding the histologic quantification of P. aeruginosa organisms in the CF tracheobronchial tree. ... Full text Link to item Cite

Recurrence of diffuse panbronchiolitis after lung transplantation

Journal Article American Journal of Respiratory and Critical Care Medicine · January 1, 1995 Diffuse panbronchiolitis (DBP) is characterized by chronic inflammation of the upper and lower respiratory tract. DPB has been found almost exclusively in oriental populations. We describe the occurrence of a case of DPB in an African American patient who ... Full text Cite

Asbestos-related disease associated with exposure to asbestiform tremolite.

Journal Article Am J Ind Med · December 1994 Tremolite is nearly ubiquitous and represents the most common amphibole fiber in the lungs of urbanites. Tremolite asbestos is not mined or used commercially but is a frequent contaminant of chrysotile asbestos, vermiculite, and talc. Therefore, individual ... Full text Link to item Cite

Biomedical applications: Pitfalls in the practice

Journal Article Proceedings - Annual Meeting, Microscopy Society of America · December 1, 1994 Most medical microprobe analysis is conducted on insoluble particulates such as asbestos fibers in lung tissue. It is necessary to flash-freeze in order to preserve the integrity of electrolyte distributions at the subcellular and cellular level. It is als ... Cite

The detection of silicone within tissues.

Journal Article Arch Pathol Lab Med · October 1994 Link to item Cite

Persistence of long, thin chrysotile asbestos fibers in the lungs of rats.

Journal Article Environ Health Perspect · October 1994 The distribution of inhaled mineral fibers in the lung determines the site and severity of disease caused by the fibers. Some of our recent work has described the fate of inhaled asbestos fibers in rodents. After a brief inhalation exposure, asbestos fiber ... Full text Link to item Cite

Effect of fibrous glass on rat pleural mesothelium. Histopathologic observations.

Journal Article Am J Respir Crit Care Med · August 1994 Female Fisher 344 rats (n = 25) were inoculated intrapleurally with a single 20-mg dose of (JM-100) fibrous glass. The mean length (2.2 microns) and width (0.15 microns) of the fibrous glass particles was within respirable range. Following inoculation, the ... Full text Link to item Cite

Cell number and distribution in human and rat airways.

Journal Article Am J Respir Cell Mol Biol · June 1994 Morphometric procedures were used to determine the number of cells, cell volume, cell diameter, and surface areas of the airways in human and rat lungs. Nuclear sizes of epithelial cells from human bronchi were significantly larger than other lung cell nuc ... Full text Link to item Cite

Fiber potency vs. importance.

Journal Article Am J Ind Med · April 1994 Full text Link to item Cite

Pulmonary thrombosis in a 10-year-old child with minimal change disease and nephrotic syndrome. A clinical, radiologic, and pathologic correlation with literature review.

Journal Article Am J Clin Pathol · February 1994 The nephrotic syndrome has long been recognized as a hypercoagulable state. Arterial thrombosis is a rare complication of the syndrome. Diuretics and steroids, standard treatment for exacerbations, have been implicated as contributing to the development of ... Full text Link to item Cite

Coexisting endogenous and exogenous lipoid pneumonia and pulmonary alveolar proteinosis in a patient with neurodevelopmental disease.

Journal Article Pediatr Pathol · 1994 We report a unique case of coexisting exogenous lipoid pneumonia, endogenous lipoid pneumonia (ELP), and pulmonary alveolar proteinosis (PAP) in a 5-year-old patient with severe neurodevelopmental disease. The patient presented with gastroesophageal reflux ... Full text Link to item Cite

Asbestos content of bronchoalveolar lavage fluid. A comparison of light and scanning electron microscopic analysis.

Journal Article Acta Cytol · 1994 We studied the asbestos content of bronchoalveolar lavage fluid (BALF) from 9 patients with asbestosis, 17 asbestos exposed but without asbestosis, 15 with idiopathic pulmonary fibrosis (IPF) and 9 nonexposed volunteers. The cellular lavage pellet was dige ... Link to item Cite

New technologies in diagnostic microscopy

Conference ELECTRON MICROSCOPY 1994, VOLS 3A AND 3B · January 1, 1994 Link to item Cite

Pulmonary drug toxicity in patients with primary breast cancer treated with high-dose combination chemotherapy and autologous bone marrow transplantation.

Journal Article Am Rev Respir Dis · May 1993 A protocol consisting of standard-dose adjuvant chemotherapy, high-dose combination alkylating agent chemotherapy, and autologous bone marrow transplant (ABMT) used at our institution for patients with primary breast cancer and extensive axillary lymph nod ... Full text Link to item Cite

Asbestos fiber type in malignant mesothelioma: an analytical scanning electron microscopic study of 94 cases.

Journal Article Am J Ind Med · April 1993 Although the association between asbestos exposure and malignant mesothelioma is indisputable, controversy continues regarding the relative contribution of the various types of asbestos fibers to the development of mesothelioma. We examined the types of as ... Full text Link to item Cite

The emphysemas: radiologic-pathologic correlations.

Journal Article Radiographics · March 1993 There are several forms of emphysema that should be considered as distinct disease entities. No university accepted classification system of these forms exists, but correlations of autopsy findings in 1,823 cases over a 12-year period confirm that the radi ... Full text Link to item Cite

Morphometric quantitation of tumor necrosis in stage 1 non-small cell carcinoma of lung: prognostic implications.

Journal Article Mod Pathol · September 1992 We objectively examined the extent of tumor necrosis by computer-assisted morphometry in 28 patients with surgically resected Stage I non-small cell carcinoma of lung. Fourteen of the 28 patients were long-term survivors (mean survival after diagnosis 94 m ... Link to item Cite

Deposition, clearance, and translocation of chrysotile asbestos from peripheral and central regions of the rat lung.

Journal Article Environ Res · June 1992 We investigated the pulmonary deposition, clearance, and translocation of chrysotile asbestos in the context of our previously developed model of asbestosis in the rat. Adult male rats were exposed for 3 hr to an aerosol of chrysotile asbestos. Subgroups w ... Full text Link to item Cite

Pulmonary oxalate deposition associated with Aspergillus niger infection. An oxidant hypothesis of toxicity.

Journal Article Am Rev Respir Dis · June 1992 Tissue injury by Aspergillus niger infection is associated with the deposition of calcium oxalate crystals. Oxalate is recognized to function as a ligand for numerous metal cations and will react with ferric ion to form a coordination complex. We describe ... Full text Link to item Cite

Absence of correlation between nuclear morphometry and survival in stage I non-small cell lung carcinoma.

Journal Article Cancer · May 15, 1992 To evaluate the utility of nuclear morphometry as a prognostic indicator in lung cancer, 5-year follow-up information was obtained in 46 cases of surgically resected Stage I non-small cell lung cancer (NSCLC). Nuclear area, perimeter, major diameter, minor ... Full text Link to item Cite

Quantitative and analytical studies in the diagnosis of mesothelioma.

Journal Article Semin Diagn Pathol · May 1992 The vast majority of patients with malignant mesothelioma of the pleura or peritoneum have an abnormal tissue asbestos content as assessed by digestion techniques. These procedures allow for the quantification of asbestos bodies, as well as numbers and typ ... Link to item Cite

Coexisting endogenous lipoid pneumonia, cholesterol granulomas, and pulmonary alveolar proteinosis in a pediatric population: a clinical, radiographic, and pathologic correlation.

Journal Article Pediatr Pathol · 1992 Benign pulmonary diseases that have been associated with the accumulation of endogenous lipids within the alveoli, bronchioles, and interstitial tissues include endogenous lipoid pneumonia (ELP), pulmonary alveolar proteinosis (PAP), pulmonary interstitial ... Full text Link to item Cite

Malignant mesothelioma in the jewelry industry.

Journal Article Am J Ind Med · 1992 We conducted a clinical, environmental, pathologic, and mineral lung burden investigation of a 61-year-old man with malignant mesothelioma. For 35 years, up until three weeks prior to pneumonectomy, the patient made asbestos soldering forms at a costume je ... Full text Link to item Cite

Mineral fiber content of lung tissue in patients with environmental exposures: household contacts vs. building occupants.

Journal Article Ann N Y Acad Sci · December 31, 1991 Analysis of tissue mineral fiber content in patients with environmental exposures has seldom been reported in the past. Our studies of six household contacts of asbestos workers indicate that these individuals often have pulmonary asbestos concentrations s ... Full text Link to item Cite

Diagnosis of diffuse malignant mesothelioma: experience of a US/Canadian Mesothelioma Panel.

Journal Article Mod Pathol · May 1991 The experience of the US/Canadian Mesothelioma Panel with its first 200 cases is reviewed. The light microscopic diagnosis, histochemical findings, immunohistochemical findings, and electron microscopic features of malignant mesotheliomas are reviewed in t ... Link to item Cite

Scanning electron microscopic analysis of mineral fiber content of lung tissue in the evaluation of diffuse pulmonary fibrosis.

Journal Article Scanning Microsc · March 1991 The mineral fiber content of lung parenchyma in 24 cases of diffuse pulmonary fibrosis of unknown cause was determined by scanning electron microscopy and compared with that of 36 autopsy cases of histologically confirmed asbestosis and 20 autopsy cases of ... Link to item Cite

Human disease consequences of fiber exposures: a review of human lung pathology and fiber burden data.

Journal Article Environ Health Perspect · August 1990 Inhalation of asbestos fibers results in a variety of neoplastic and nonneoplastic diseases of the respiratory tract. Some of these diseases, such as asbestosis, generally occur after prolonged and intensive exposure to asbestos, whereas others, such as pl ... Full text Link to item Cite

Asbestos bodies in pulmonary hilar lymph nodes.

Journal Article Mod Pathol · July 1990 Asbestos bodies (AB) have long been recognized in light microscopic (LM) sections of pulmonary hilar lymph nodes (LN) from patients with asbestos-related diseases, but the presence of AB on LM has not been correlated with the lung AB burden. The purpose of ... Link to item Cite

Asbestos in lung tissue.

Journal Article Chest · June 1990 Full text Link to item Cite

Reply

Journal Article Human Pathology · January 1, 1990 Full text Cite

Autofluorescent substances as control specimens (I: Reply)

Journal Article Human Pathology · January 1, 1990 Cite

Immunohistochemical differentiation of sarcomatoid mesotheliomas from other spindle cell neoplasms.

Journal Article Am J Clin Pathol · November 1989 A sizable proportion of pleural malignant mesotheliomas are sarcomatoid (22%) or biphasic (24%) and may need to be distinguished from other spindle cell neoplasms that occur as primary or metastatic tumors of the chest wall or lungs. To determine the utili ... Full text Link to item Cite

Pulmonary lymphangioleiomyomatosis: CT findings.

Journal Article AJR Am J Roentgenol · November 1989 Lymphangioleiomyomatosis, a rare disease occurring in women of childbearing age, is characterized by proliferation of smooth muscle in pulmonary lymphatic channels and mediastinal and abdominal lymph nodes. Chest radiographs typically reveal interstitial d ... Full text Link to item Cite

Eosinophilic intracytoplasmic globules in pulmonary adenocarcinomas: a histochemical, immunohistochemical, and ultrastructural study of six cases.

Journal Article Hum Pathol · September 1989 Intracytoplasmic globules have been described in a variety of neoplastic and nonneoplastic conditions, but remain poorly defined. In a review of 100 consecutive cases of lung carcinomas, six cases of mucin-positive adenocarcinoma demonstrated eosinophilic ... Full text Link to item Cite

Ultrastructural morphology of the lung in cystic fibrosis.

Journal Article J Submicrosc Cytol Pathol · July 1989 Cystic fibrosis (CF) is the most common lethal genetic disease among Caucasians, with much of the morbidity and most of the mortality related to pulmonary complications. The underlying defect in this disease has yet to be precisely defined, so it is somewh ... Link to item Cite

The accumulation of nickel in human lungs.

Journal Article Environ Health Perspect · May 1989 Using data from published studies, lung concentrations of nickel were compare for persons with and without occupational exposure to nickel. As expected, the concentrations were much higher for persons with occupational exposure. To estimate the effects of ... Full text Link to item Cite

Dendriform pulmonary ossification. Report of two cases with unique findings.

Journal Article Am J Clin Pathol · April 1989 Dendriform pulmonary ossification (DPO) is a rare condition characterized by branching bony spicules found in association with pulmonary fibrosis. The authors report two cases, the first of which occurred in a patient with acute myeloblastic leukemia and w ... Full text Link to item Cite

CT appearance of lunate trachea.

Journal Article J Comput Assist Tomogr · 1989 Computed tomography provides excellent visualization of the trachea, but there have been only limited descriptions of variations in tracheal shape. The normal tracheal cartilage is U shaped. Lunate shaped trachea is uncommon and is characterized by a coron ... Full text Link to item Cite

Calcified intralobar pulmonary sequestration.

Journal Article Can Assoc Radiol J · December 1988 The radiologic features of intralobar pulmonary sequestration (ILPS) have been described and include the identification of a feeding systemic artery on computerized tomography. Radiographically demonstrated calcification is rare and has been described only ... Link to item Cite

Aspergillus terreus as a cause of invasive pulmonary aspergillosis.

Journal Article Chest · October 1988 A 70-year-old woman with nodular, poorly differentiated lymphocytic lymphoma is the third reported patient with invasive pulmonary aspergillosis caused by Aspergillus terreus. This case differs from the two previously reported in that neither neutropenia n ... Full text Link to item Cite

Prognostic indicators for survival in stage I carcinoma of the lung: a histologic study of 47 surgically resected cases.

Journal Article Mod Pathol · July 1988 In a previous study of 91 consecutive lung cancer cases, we reported that tumor stage was the only significant predictor of survival, with all 5-yr survivors having Stage I disease. Approximately half of the 47 Stage I cases survived 5 yr, so the present s ... Link to item Cite

The secondary pulmonary lobule: normal and abnormal CT appearances.

Journal Article AJR Am J Roentgenol · July 1988 The secondary pulmonary lobule is a unit of lung supplied by three to five terminal bronchioles and contained by fibrous septa. High-resolution CT is able to show features of the secondary lobule, including interlobular septa, terminal bronchioles, and pul ... Full text Link to item Cite

Interstitial lung disease and domestic wood burning.

Journal Article Am Rev Respir Dis · May 1988 A 61-yr-old woman was evaluated for dyspnea on exertion and interstitial lung disease. A unique association between inhaled particulates from wood burning and interstitial pneumonitis was demonstrated. Bronchoalveolar lavage revealed numerous particulates ... Full text Link to item Cite

Pulmonary carcinomas with a sarcomatoid element: an immunocytochemical and ultrastructural analysis.

Journal Article Hum Pathol · February 1988 Eight primary carcinomas of the lung with a prominent spindle-cell sarcomatoid component were studied by immunocytochemical staining and electron microscopy. The eight tumors were indistinguishable by conventional light microscopy, with the exception of on ... Full text Link to item Cite

Mesothelioma vs. adenocarcinoma.

Journal Article Am J Surg Pathol · February 1988 Full text Link to item Cite

Giant cell interstitial pneumonia in a hard-metal worker. Cytologic, histologic and analytical electron microscopic investigation.

Journal Article Acta Cytol · 1988 A case of biopsy-proven giant cell interstitial pneumonia in a patient with occupational exposure to hard-metal dust is reported. Bronchial washings performed several days prior to open-lung biopsy yielded an almost exclusive population of nonpigmented alv ... Link to item Cite

Pleural amyloidosis.

Journal Article Arch Pathol Lab Med · January 1988 Pleural amyloidosis has been reported rarely, and the diagnosis of this disease by Cope needle biopsy has, to our knowledge, been reported only once previously. We report two patients in whom the diagnosis of pleural amyloidosis was made by biopsy specimen ... Link to item Cite

Lower incidence of death from chronic renal disease in patients with nonlethal emphysema: a statistical study.

Journal Article Mod Pathol · January 1988 Pulmonary emphysema is an extraordinarily prevalent disease, especially among men, and is found in about 40% of all autopsies at this Veterans Medical Center. However, in the great majority of cases, it is an incidental finding, and the individual has died ... Link to item Cite

Cartilaginous variant of congenital adenomatoid malformation of the lung.

Journal Article Chest · September 1987 We report the occurrence of an unusual variant of congenital adenomatoid malformation (CAM) of the lung in a 16-year-old male. Abundant cartilage in the walls of malformed bronchioles, an extremely rare finding in CAM, distinguishes this lesion from the us ... Full text Link to item Cite

Lung cancer heterogeneity. Prognostic implications.

Journal Article Cancer · August 1, 1987 Although histologic heterogeneity of lung cancer is well recognized, little information is available related to possible effects of this heterogeneity on prognosis. We collected 100 consecutive lung cancer cases, including 35 autopsies and 65 surgical rese ... Full text Link to item Cite

Polypoid tumor of the esophagus.

Journal Article Hum Pathol · July 1987 Five cases of an uncommon esophageal tumor consisting of a mucosal squamous cell carcinoma that surrounds a polypoid mass of spindle cells were examined. The spindle cell component was composed of elongated cells with blunt nuclei, admixed with multinuclea ... Full text Link to item Cite

Clearance and dimensional changes of crocidolite asbestos fibers isolated from lungs of rats following short-term exposure.

Journal Article Environ Res · February 1987 Previous studies in this laboratory have demonstrated fiber clearance and dimensional changes in chrysotile asbestos using a rat inhalational model of short-term exposure. The purpose of the present study was to determine whether or not similar changes occ ... Full text Link to item Cite

Acute interstitial pneumonia.

Journal Article Am J Surg Pathol · February 1987 Full text Link to item Cite

Airway branching patterns influence asbestos fiber location and the extent of tissue injury in the pulmonary parenchyma.

Journal Article Lab Invest · December 1986 The degree to which various anatomic components of the lung influence the distribution of inhaled particles is not entirely clear. Therefore, we have studied the role intrapulmonary airways play in the localization of respired asbestos fibers and have corr ... Link to item Cite

Pleural malignant mesothelioma following Wilms' tumor.

Journal Article Am J Clin Pathol · August 1986 A 28-year-old woman had a left pleural malignant mesothelioma develop, which resulted in her death. At age four, she had undergone a left nephrectomy for Wilms' tumor and had received radiation therapy to the left renal fossa and to the right lung, the lat ... Full text Link to item Cite

Centrilobular emphysema: CT-pathologic correlation.

Journal Article Radiology · April 1986 Over a 5-year period, 25 patients who had undergone chest computed tomography (CT) died and were autopsied. Their lungs were fixed in the inflated state and were assessed for the presence and severity of centrilobular emphysema (CLE). Three radiologists in ... Full text Link to item Cite

LONG-TERM RETENTION OF CHRYSOTILE ASBESTOS FOLLOWING ACUTE INHALATION

Journal Article AMERICAN REVIEW OF RESPIRATORY DISEASE · April 1, 1986 Link to item Cite

The diagnostic distinction between malignant mesothelioma of the pleura and adenocarcinoma of the lung as defined by a monoclonal antibody (B72.3).

Journal Article Am J Pathol · February 1986 The correct distinction between malignant mesothelioma of the pleura and adenocarcinoma of the lung has become increasingly complex, with a variety of histochemical, immunohistochemical, and ultrastructural studies to be performed on biopsy material. The r ... Link to item Cite

Asbestos content of lung tissue in asbestos associated diseases: a study of 110 cases.

Journal Article Br J Ind Med · January 1986 Diseases associated with asbestos exposure include asbestosis, malignant mesothelioma, carcinoma of the lung, and parietal pleural plaques. In this study the asbestos content of lung tissue was examined in groups of cases representing each of these disease ... Full text Link to item Cite

Asbestos bodies in bronchoalveolar lavage fluid. A study of 20 asbestos-exposed individuals and comparison to patients with other chronic interstitial lung diseases.

Journal Article Acta Cytol · 1986 We studied the asbestos body (AB) content of bronchoalveolar lavage fluid from 20 patients with a history of occupational asbestos exposure, 31 patients with sarcoidosis and 5 patients with idiopathic pulmonary fibrosis. The cellular lavage pellet was dige ... Link to item Cite

Carcinoma of the lung with osseous stromal metaplasia.

Journal Article Arch Pathol Lab Med · November 1985 Calcification has long been a determinant in the radiologic distinction of a benign pulmonary mass. However, rare examples of calcification without ossification in pulmonary adenocarcinoma and ossification in the bronchial carcinoid have led some investiga ... Link to item Cite

Crystalline foreign particulate material in hernia sacs.

Journal Article Hum Pathol · November 1985 The subserosal stroma of hernia sacs consistently contains birefringent particulate material, in amounts greater than those observed in other intra-abdominal organs. The major component of this material was shown in the present study to be talc; thus, it c ... Full text Link to item Cite

Asbestos body concentrations in human lung: predictions from asbestos body counts in tissue sections with a mathematical model.

Journal Article Hum Pathol · July 1985 A mathematical model for predicting the concentration (Nv) of asbestos bodies (AB) in human tissue from the count (No) of these bodies in planar tissue sections is presented. The result is the equation Nv = No/[0.54 X A X (La + t)], giving the concentratio ... Full text Link to item Cite

Anterior chest wall mass in an elderly male.

Journal Article Invest Radiol · July 1985 A case of chondrosarcoma arising from the right anterior second rib in an 84-year-old man is described. Radiographic features include amorphous calcification within a chest wall mass. CT findings include calcification and necrosis within the 8 X 8 X 10 cm ... Full text Link to item Cite

Lung cancer heterogeneity: a blinded and randomized study of 100 consecutive cases.

Journal Article Hum Pathol · June 1985 The heterogeneity of lung carcinomas was recognized in the past, but few previous studies attempted to quantitate this heterogeneity. In the present study 100 consecutive cases of lung carcinoma (65 surgical resections and 35 autopsies) were collected, and ... Full text Link to item Cite

Analysis of asbestos fibers and asbestos bodies in tissue samples from human lung. An international interlaboratory trial.

Journal Article Scand J Work Environ Health · April 1985 In order to compare methods of counting asbestos fibers in lung tissue, seven laboratories participated in an interlaboratory trial in which tissue samples from five human lungs were analyzed. In some laboratories, fiber concentrations were assessed with t ... Full text Link to item Cite

Microprobe analysis in human pathology.

Journal Article Scan Electron Microsc · 1985 This tutorial paper reviews the literature on the application of microprobe analysis to practical problems in diagnostic human pathology. The goal is to allow the reader ready access to the literature on specific clinical problems. Specimen preparation and ... Link to item Cite

Pulmonary pathology of Rocky Mountain spotted fever (RMSF) in children.

Journal Article Pediatr Pathol · 1985 Despite infrequent respiratory symptoms, histopathologic changes were identified in the lungs of 15 of 16 children dying of Rocky Mountain spotted fever (RMSF). Gross examination demonstrated increased lung weight, edema, congestion, focal hemorrhage, and ... Full text Link to item Cite

Parietal pleural plaques, asbestos bodies, and neoplasia. A clinical, pathologic, and roentgenographic correlation of 25 consecutive cases.

Journal Article Chest · November 1984 An investigation was made to correlate autopsy and roentgenographic findings of pleural plaques with occupational exposure to asbestos and occurrence of respiratory tract tumors. Of the 434 autopsies performed over a 2 1/2 year period, 25 (5.8 percent) had ... Full text Link to item Cite

New techniques for imaging and analyzing lung tissue.

Journal Article Environ Health Perspect · June 1984 The recent technological revolution in the field of imaging techniques has provided pathologists and toxicologists with an expanding repertoire of analytical techniques for studying the interaction between the lung and the various exogenous materials to wh ... Full text Link to item Cite

Changes in numbers and dimensions of chrysotile asbestos fibers in lungs of rats following short-term exposure.

Journal Article Exp Lung Res · 1984 Previous studies from this laboratory have demonstrated that in rats exposed briefly to aerosolized chrysotile asbestos, fibers initially deposited in the distal lung impact primarily at bifurcations of alveolar ducts. Subsequently, there is a progressive ... Full text Link to item Cite

Asbestos bodies in fine needle aspirates of the lung.

Journal Article Acta Cytol · 1984 Asbestos bodies, which are the hallmark of exposure to asbestos, were identified in cytologic preparations from fine needle aspirates of the lung in two individuals, one with considerable occupational exposure to asbestos and one for whom no source of asbe ... Link to item Cite

Pulmonary blastoma: an ultrastructural and histochemical study.

Journal Article Ultrastruct Pathol · 1984 We present a unique case of pulmonary blastoma and describe its histology and ultrastructure. The stromal component exhibited bizarre multinucleated giant cells containing previously undescribed granules. These membrane-limited granules were eosinophilic, ... Full text Link to item Cite

LUNG-CARCINOMA HETEROGENEITY - A LIGHT MICROSCOPIC STUDY

Journal Article LABORATORY INVESTIGATION · January 1, 1984 Link to item Cite

Numbers of asbestos bodies on iron-stained tissue sections in relation to asbestos body counts in lung tissue digests.

Journal Article Hum Pathol · April 1983 Utilization of tissue digestion techniques has demonstrated the presence of large numbers of asbestos bodies within lungs of persons after occupational exposure to asbestos, and smaller numbers in the vast majority of persons with no identifiable exposure. ... Full text Link to item Cite

Detection of pulmonary emboli in dogs: comparison of single photon emission computed tomography, gamma camera imaging, and angiography.

Journal Article Radiology · February 1983 Single photon emission computed tomography (SPECT) allows separation of radionuclide activity in front of and behind the area of interest and results in more contrast than can be achieved using conventional gamma camera imaging. To determine if this improv ... Full text Link to item Cite

LOW OR ABSENT IMMUNOGLOBULINS AT THE BRONCHOALVEOLAR SURFACE IN PATIENTS WITH ASBESTOSIS

Journal Article AMERICAN REVIEW OF RESPIRATORY DISEASE · January 1, 1983 Link to item Cite

Asbestos bodies in sputum: A clinical marker of exposure: To the editor

Journal Article Journal of Occupational Medicine · January 1, 1983 Cite

CORRECTION

Journal Article HUMAN PATHOLOGY · 1983 Cite

Pulmonary asbestos body counts and electron probe analysis of asbestos body cores in patients with mesothelioma: a study of 25 cases.

Journal Article Cancer · December 1, 1982 Malignant mesotheliomas of the pleura and peritoneum are well-recognized risks of asbestos exposure. We determined the asbestos body content of the lungs from 24 cases of malignant mesothelioma (19 pleural, five peritoneal) and compared such to the content ... Full text Link to item Cite

Rapid histological staining procedures for material from immune-suppressed patients.

Journal Article Am J Med Technol · November 1982 Immunocompromised patients require rapid diagnosis of infectious conditions, if treatment is to be effective. This paper describes rapid techniques for the identification of pathogens from transbronchial and other biopsy specimens. Included are rapid proce ... Link to item Cite

New Concepts in the Diagnosis of Mineral Pneumoconioses

Journal Article Seminars in Respiratory and Critical Care Medicine · October 1982 Full text Cite

Erythroleukemia: a study of 15 cases and literature review.

Journal Article Cancer · January 1, 1982 Out of a total of 185 cases of acute leukemia at our institution from 1967 to 1978, fifteen cases (8.1%) were identified as erythroleukemia or erythremic myelosis. The symptoms at presentation were often related to anemia (10/15 cases); the presenting hemo ... Full text Link to item Cite

ASBESTOS BODIES IN SPUTUM - THEIR CLINICAL-SIGNIFICANCE

Journal Article AMERICAN REVIEW OF RESPIRATORY DISEASE · 1982 Cite

Prognostic factors and treatment effects on survival in erythroleukemia: a retrospective study of 134 cases.

Journal Article Cancer · September 1, 1981 A total of 134 cases of erythroleukemia (119 from the literature and 15 of the authors' patients) were reviewed in an attempt to correlate survival with age, sex, hepatomegaly, splenomegaly, lymphadenopathy, infection, or hemorrhagic complications at initi ... Full text Link to item Cite

Alpha-1-antitrypsin globules in hepatocytes of elderly persons with liver disease.

Journal Article Am J Clin Pathol · April 1981 Percutaneous needle biopsy specimens of the liver from three elderly persons (aged 77, 71, and 66) demonstrated eosinophilic intracytoplasmic globules within hepatocytes, particularly in the periportal and periseptal areas. These globules were periodic aci ... Full text Link to item Cite

Comparison of sputum and lung asbestos body counts in former asbestos workers.

Journal Article Am Rev Respir Dis · December 1980 The asbestos (ferruginous) body content of lung tissues was compared to the number of asbestos bodies (AB) in sputum from 6 former amosite asbestos workers. Lung tissue was obtained at autopsy (5 subjects) and lobectomy (1 subject), and AB content was dete ... Full text Link to item Cite

Asbestos body content of the larnyx in asbestos workers. A study of five cases.

Journal Article Arch Otolaryngol · September 1980 Occupational exposure to asbestos has been epidemiologically associated with carcinoma of the larynx; however, no search for or quantitation of laryngeal asbestos bodies has been performed. This report concerns an autopsy study of five patients with occupa ... Full text Link to item Cite

Pulmonary fibrosis, carcinoma, and ferruginous body counts in amosite asbestos workers. A study of six cases.

Journal Article Am J Clin Pathol · April 1980 The Tyler Asbestos Workers Program is a continuing study of 1,105 former amosite asbestos workers. This report includes a study of six former workers, five of whom died and had autopsies, and one who underwent a lobectomy. Five of these men were exposed to ... Full text Link to item Cite

Asbestos body phagocytosis by human free alveolar macrophages.

Journal Article Cancer Lett · April 1980 Phagocytosis of asbestos bodies by human free alveolar macrophages (FAMs) was documented employing light microscopy. This process was more carefully studied utilizing scanning electron microscopy (SEM) which demonstrated morphological and surface membrane ... Full text Link to item Cite

Scanning electron microscopic examination of human asbestos bodies.

Journal Article Cancer Lett · April 1980 Asbestos bodies represent the product of the macrophage's attempt to detoxify inhaled asbestos fibers. The process of asbestos body maturation was examined by scanning electron microscopy of material isolated from lungs of former asbestos workers. The resu ... Full text Link to item Cite

Congenital generalized fibromatosis with visceral involvement. A case report.

Journal Article Cancer · March 1, 1980 A case of congenital generalized fibromatosis in a black male infant with involvement of lungs, subcutaneous tissue, pancreas, adrenal, lymph nodes, and bone is described. Fifteen prior cases with pulmonary involvement are reviewed, emphasizing the poor pr ... Full text Link to item Cite

Pulmonary fibrosis, carcinoma and ferruginous body counts in amosite asbestos workers: A study of six cases

Journal Article American Journal of Clinical Pathology · January 1, 1980 Cite

Pituitary microadenoma and primary lymphoma of brain associated with hypothalamic invasion.

Journal Article Am J Clin Pathol · June 1979 A case of primary histiocytic lymphoma involving the left temporal lobe and hypothalamus is presented. This lesion was associated with a pituitary microadenoma shown immunohistochemically to contain prolactin and with lactational changes in the breasts. Th ... Full text Link to item Cite

Thyroid neoplasia following irradiation for medulloblastoma: report of two cases.

Journal Article Cancer · June 1979 Thyroid neoplasms occurred in two patients 14 and 18 years after treatment with radiation for medulloblastoma. One patient has a papillary cancer and the other patient had multiple adenomas and a Hurthle cell adenoma. In addition, the latter case had foci ... Full text Link to item Cite

Duodenal glucagonoma: a case report.

Journal Article Hum Pathol · May 1979 A case of a primary carcinoid islet cell tumor of the duodenum is reported, demonstrated by histochemistry, electron microscopy, and immunofluorescence to be composed of alpha cells containing glucagon-like material. The patient was found on admission to h ... Full text Link to item Cite