Scholars@Duke
Scott Daniel Moore

Scott Daniel Moore

Professor Emeritus of Psychiatry and Behavioral Sciences
Psychiatry & Behavioral Sciences, Adult Psychiatry & Psychology
sdmoore@duke.edu
Box 3309 Med Ctr, Durham, NC 27710
116A VA Med Ctr, 508 Fulton St, Durham, NC 27705

Selected Publications

Black Americans With Sickle Cell Disease (SCD) Demonstrate Accelerated Epigenetic Pace of Aging Compared to Black Americans Without SCD.

Journal Article J Gerontol A Biol Sci Med Sci · November 1, 2024 BACKGROUND: Sickle cell disease (SCD) is a chronic medical condition characterized by red blood cell sickling, vaso-occlusion, hemolytic anemia, and subsequently, end-organ damage and reduced survival. Because of this significant pathophysiology and early ... Full text Link to item Cite

George Robert Siggins: Researcher, musician, surfer, mentor, and friend.

Journal Article Alcohol Clin Exp Res (Hoboken) · September 2024 Full text Link to item Cite

Posttraumatic stress disorder, trauma, and accelerated biological aging among post-9/11 veterans.

Journal Article Transl Psychiatry · January 6, 2024 People who experience trauma and develop posttraumatic stress disorder (PTSD) are at increased risk for poor health. One mechanism that could explain this risk is accelerated biological aging, which is associated with the accumulation of chronic diseases, ... Full text Open Access Link to item Cite

Multimodal smoking cessation treatment combining repetitive transcranial magnetic stimulation, cognitive behavioral therapy, and nicotine replacement in veterans with posttraumatic stress disorder: A feasibility randomized controlled trial protocol.

Journal Article PLoS One · 2024 Tobacco-related deaths remain the leading cause of preventable death in the United States. Veterans suffering from posttraumatic stress disorder (PTSD)-about 11% of those receiving care from the Department of Veterans Affairs (VA)-have triple the risk of d ... Full text Link to item Cite

Sustained overexpression of spliced X-box-binding protein-1 in neurons leads to spontaneous seizures and sudden death in mice.

Journal Article Commun Biol · March 9, 2023 The underlying etiologies of seizures are highly heterogeneous and remain incompletely understood. While studying the unfolded protein response (UPR) pathways in the brain, we unexpectedly discovered that transgenic mice (XBP1s-TG) expressing spliced X-box ... Full text Link to item Cite

Probable trauma associated sleep disorder in post-9/11 US Veterans.

Journal Article Sleep Adv · 2023 STUDY OBJECTIVES: The purpose of this study was to (1) estimate trauma associated sleep disorder (TASD) prevalence among post-9/11 era veterans and to describe differences in service and comorbid mental health clinical characteristics among individuals wit ... Full text Open Access Link to item Cite

Digital Medicine System in Veterans With Severe Mental Illness: Feasibility and Acceptability Study.

Journal Article JMIR Form Res · December 22, 2022 BACKGROUND: Suboptimal medication adherence is a significant problem for patients with serious mental illness. Measuring medication adherence through subjective and objective measures can be challenging, time-consuming, and inaccurate. OBJECTIVE: The prima ... Full text Open Access Link to item Cite

Warzone experiences and subsequent clinician suicide risk assessment in veterans

Journal Article Suicide and Life Threatening Behavior · December 1, 2021 Objective: To determine in veterans whether severity of combat exposure was predictive of subsequently receiving a suicide risk assessment (SRA), and whether this relationship was meditated by depression symptomatology. Method: We conducted an electronic m ... Full text Cite

Effects of sex and genotype in human APOE-targeted replacement mice on alcohol self-administration measured with the automated IntelliCage system before and after repeated mild traumatic brain injury.

Journal Article Alcohol Clin Exp Res · November 2021 BACKGROUND: Few studies have examined the association between APOE genotype and alcohol use. Although some of these studies have reported outcomes associated with a history of drinking, none have examined alcohol-seeking behavior. In addition, no preclinic ... Full text Link to item Cite

A network analysis of risk factors for suicide in Iraq/Afghanistan-era veterans.

Journal Article J Psychiatr Res · June 2021 Suicidal ideation (SI) is a prevalent issue in the veteran population. A number of factors have been identified as risk factors for suicidal ideation (SI) in veterans, including suicide attempts, depression, posttraumatic stress disorder (PTSD), and drug u ... Full text Link to item Cite

Cannabis use disorder, anger, and violence in Iraq/Afghanistan-era veterans.

Journal Article J Psychiatr Res · June 2021 An association has been found between cannabis use disorder (CUD) and violence in several clinical populations, including veterans with posttraumatic stress disorder (PTSD), and there is evidence that CUD has been increasing among veterans since September ... Full text Link to item Cite

Screening for moral injury and comparatively evaluating moral injury measures in relation to mental illness symptomatology and diagnosis.

Journal Article Clin Psychol Psychother · January 2021 Moral injury merits further study to clarify its identification, prevalence, assessment and intersection with psychosocial and psychiatric problems. The present study investigated the screening potential of the Brief Moral Injury Screen (BMIS) in a sample ... Full text Link to item Cite

Gene Expression Analysis in Three Posttraumatic Stress Disorder Cohorts Implicates Inflammation and Innate Immunity Pathways and Uncovers Shared Genetic Risk With Major Depressive Disorder.

Journal Article Front Neurosci · 2021 Posttraumatic stress disorder (PTSD) is a complex psychiatric disorder that can develop following exposure to traumatic events. The Psychiatric Genomics Consortium PTSD group (PGC-PTSD) has collected over 20,000 multi-ethnic PTSD cases and controls and has ... Full text Open Access Link to item Cite

Pilot Cohorts for Development of Concurrent Mobile Treatment for Alcohol and Tobacco Use Disorders.

Journal Article Subst Abuse · 2021 Alcohol and tobacco are the 2 most frequently used drugs in the United States and represent the highest co-occurrence of polysubstance use. The objective of this study was to refine an intervention combining mobile contingency management with cognitive-beh ... Full text Open Access Link to item Cite

Epigenome-wide meta-analysis of PTSD across 10 military and civilian cohorts identifies methylation changes in AHRR.

Journal Article Nat Commun · November 24, 2020 Epigenetic differences may help to distinguish between PTSD cases and trauma-exposed controls. Here, we describe the results of the largest DNA methylation meta-analysis of PTSD to date. Ten cohorts, military and civilian, contribute blood-derived DNA meth ... Full text Link to item Cite

Multiple sources of internal calcium stores mediate ethanol-induced presynaptic inhibitory GABA release in the central nucleus of the amygdala in mice.

Journal Article Psychopharmacology (Berl) · November 2020 RATIONALE: Ethanol can enhance GABA release in various brain regions via presynaptic mechanisms. However, the presynaptic action of ethanol on inhibitory GABA release is still not well understood. OBJECTIVES: Since calcium is required for neurotransmitter ... Full text Link to item Cite

Neural correlates of conceptual-level fear generalization in posttraumatic stress disorder.

Journal Article Neuropsychopharmacology · July 2020 Posttraumatic stress disorder (PTSD) may develop when mechanisms for making accurate distinctions about threat relevance have gone awry. Generalization across conceptually related objects has been hypothesized based on clinical observation in PTSD, but the ... Full text Link to item Cite

Amygdala Nuclei Volume and Shape in Military Veterans With Posttraumatic Stress Disorder.

Journal Article Biol Psychiatry Cogn Neurosci Neuroimaging · March 2020 BACKGROUND: The amygdala is a subcortical structure involved in socioemotional and associative fear learning processes relevant for understanding the mechanisms of posttraumatic stress disorder (PTSD). Research in animals indicates that the amygdala is a h ... Full text Link to item Cite

Threat-induced anxiety during goal pursuit disrupts amygdala-prefrontal cortex connectivity in posttraumatic stress disorder.

Journal Article Transl Psychiatry · February 10, 2020 To investigate how unpredictable threat during goal pursuit impacts fronto-limbic activity and functional connectivity in posttraumatic stress disorder (PTSD), we compared military veterans with PTSD (n = 25) vs. trauma-exposed control (n = 25). Participan ... Full text Link to item Cite

Combat exposure, posttraumatic stress disorder, and head injuries differentially relate to alterations in cortical thickness in military Veterans.

Journal Article Neuropsychopharmacology · February 2020 Combat-exposed Veterans are at increased risk for developing psychological distress, mood disorders, and trauma and stressor-related disorders. Trauma and mood disorders have been linked to alterations in brain volume, function, and connectivity. However, ... Full text Link to item Cite

Pain Intensity and Pain Interference in Male and Female Iraq/Afghanistan-era Veterans.

Journal Article Womens Health Issues · June 25, 2019 BACKGROUND: Chronic pain conditions are common among both male and female Iraq/Afghanistan-era veterans and can have substantial negative impacts on quality of life and function. Although in general women tend to report higher levels of pain intensity than ... Full text Link to item Cite

General anesthetic exposure in adolescent rats causes persistent maladaptations in cognitive and affective behaviors and neuroplasticity.

Journal Article Neuropharmacology · May 15, 2019 Accumulating evidence indicates that exposure to general anesthetics during infancy and childhood can cause persistent cognitive impairment, alterations in synaptic plasticity, and, to a lesser extent, increased incidence of behavioral disorders. Unfortuna ... Full text Link to item Cite

Relationship between traumatic brain injury history and recent suicidal ideation in Iraq/Afghanistan-era veterans.

Journal Article Psychol Serv · May 2019 This study evaluated whether a history of traumatic brain injury (TBI) was associated with increased risk for recent suicidal ideation (SI) after accounting for demographics, depression, posttraumatic stress disorder (PTSD), and sleep quality. In terms of ... Full text Link to item Cite

Posttraumatic stress disorder and traumatic brain Injury: Sex differences in veterans.

Journal Article Psychiatry Res · April 2019 Around half of Iraq and Afghanistan war veterans with traumatic brain injury (TBI) have co-occurring posttraumatic stress disorder (PTSD). Research on the differences between male and female veterans with co-occurring PTSD/TBI is sparse. This study evaluat ... Full text Link to item Cite

Patient-Informed Treatment Development of Behavioral Smoking Cessation for People With Schizophrenia.

Journal Article Behav Ther · March 2019 The objective of this study was to use qualitative methodology to tailor and refine an existing smoking cessation intervention for the population of people who use cigarettes and are diagnosed with schizophrenia, schizoaffective, or psychotic disorder. Suc ... Full text Link to item Cite

Cigarette smoking rates among veterans: Association with rurality and psychiatric disorders.

Journal Article Addict Behav · March 2019 AIMS: Compared to the general U.S. population, military veterans and those living in rural areas disproportionately smoke cigarettes at higher rates, leading to increased health consequences. In the current study, prevalence and severity of cigarette smoki ... Full text Link to item Cite

Pilot Trial of a Combined Cognitive Processing Therapy and Smoking Cessation Treatment.

Journal Article J Addict Med · 2019 OBJECTIVE/BACKGROUND: Posttraumatic stress disorder (PTSD) and smoking are often comorbid. Combining PTSD and smoking cessation treatments could increase access to each treatment and could provide improved rates of smoking cessation through reductions in P ... Full text Link to item Cite

The association of resilience on psychiatric, substance use, and physical health outcomes in combat trauma-exposed military service members and veterans.

Journal Article Eur J Psychotraumatol · 2019 Objective: Although Combat exposure is associated with a range of psychiatric outcomes, many veterans do not develop psychopathology. Resilience is a multifaceted construct associated with reduced risk of distress and psychopathology; however, few studies ... Full text Open Access Link to item Cite

Behavioral and Health Outcomes Associated With Deployment and Nondeployment Acquisition of Traumatic Brain Injury in Iraq and Afghanistan Veterans.

Journal Article Arch Phys Med Rehabil · December 2018 OBJECTIVE: To characterize behavioral and health outcomes in veterans with traumatic brain injury (TBI) acquired in nondeployment and deployment settings. DESIGN: Cross-sectional assessment evaluating TBI acquired during and outside of deployment, mental a ... Full text Link to item Cite

Psychosocial Risk Factors and Other Than Honorable Military Discharge: Providing Healthcare to Previously Ineligible Veterans.

Journal Article Mil Med · September 1, 2018 INTRODUCTION: In response to a strong focus on suicide prevention for all veterans, the Department of Veterans Affairs (VA) recently revised policy to provide emergency mental healthcare for veterans who received Other Than Honorable (OTH) discharges from ... Full text Link to item Cite

Informing Federal Policy on Firearm Restrictions for Veterans with Fiduciaries: Risk Indicators in the Post-Deployment Mental Health Study.

Journal Article Adm Policy Ment Health · July 2018 This article examines the public safety rationale for a federal policy of prohibiting gun sales to veterans with psychiatric disabilities who are assigned a fiduciary to manage their benefits from the Department of Veterans Affairs. The policy was evaluate ... Full text Link to item Cite

Mechanisms of increased hippocampal excitability in the Mashl+/- mouse model of Na+ /K+ -ATPase dysfunction.

Journal Article Epilepsia · July 2018 OBJECTIVE: Na+ /K+ -ATPase dysfunction, primary (mutation) or secondary (energy crisis, neurodegenerative disease) increases neuronal excitability in the brain. To evaluate the mechanisms underlying such increased excitability we studied mice carrying the ... Full text Link to item Cite

The Association Between Alcohol Consumption, Lifetime Alcohol Use Disorder, and Psychiatric Distress Among Male and Female Veterans.

Journal Article J Stud Alcohol Drugs · July 2018 OBJECTIVE: This study aimed to examine among veterans (a) whether alcohol consumption patterns are associated with probability of psychiatric symptoms and (b) whether an alcohol use disorder (AUD) history explains psychiatric symptoms among nondrinkers. ME ... Full text Link to item Cite

Risk factors for concurrent suicidal ideation and violent impulses in military veterans.

Journal Article Psychol Assess · April 2018 Suicide and violence are significant problems in a subset of Iraq/Afghanistan-era veterans. This study investigates how posttraumatic stress disorder (PTSD) and resilience in veterans are associated with suicidal ideation and violent impulses while control ... Full text Link to item Cite

Mobile contingency management as an adjunctive treatment for co-morbid cannabis use disorder and cigarette smoking.

Journal Article Addict Behav · April 2018 INTRODUCTION: Cannabis is the most widely used illicit drug in the U.S. with 19.8 million current users. Population-based data indicate that almost all cannabis users (90%) have a lifetime history of tobacco smoking and the majority (74%) currently smoke t ... Full text Link to item Cite

Brain Structural Covariance Network Topology in Remitted Posttraumatic Stress Disorder.

Journal Article Front Psychiatry · 2018 Posttraumatic stress disorder (PTSD) is a prevalent, chronic disorder with high psychiatric morbidity; however, a substantial portion of affected individuals experience remission after onset. Alterations in brain network topology derived from cortical thic ... Full text Link to item Cite

Exploring resilience models in a sample of combat-exposed military service members and veterans: a comparison and commentary.

Journal Article Eur J Psychotraumatol · 2018 Background: The term resilience is applied in numerous ways in the mental health field, leading to different perspectives of what constitutes a resilient response and disparate findings regarding its prevalence following trauma. Objective: illustrate the i ... Full text Link to item Cite

Sleep quality in returning veterans: The influence of mild traumatic brain injury.

Journal Article Rehabil Psychol · November 2017 OBJECTIVE: Sleep disturbance is a key behavioral health concern among Iraq and Afghanistan era veterans and is a frequent complaint among veterans with a history of mild traumatic brain injury (mTBI). Currently, it is unclear whether sleep disturbance is a ... Full text Link to item Cite

Self-Reported Pain in Male and Female Iraq/Afghanistan-Era Veterans: Associations with Psychiatric Symptoms and Functioning.

Journal Article Pain Med · September 1, 2017 OBJECTIVE: To examine pain symptoms and co-occurring psychiatric and functional indices in male and female Iraq/Afghanistan-era veterans. DESIGN: Self-reported data collection and interviews of Iraq/Afghanistan-era veterans who participated in a multisite ... Full text Link to item Cite

The Post-Deployment Mental Health (PDMH) study and repository: A multi-site study of US Afghanistan and Iraq era veterans.

Journal Article Int J Methods Psychiatr Res · September 2017 The United States (US) Department of Veterans Affairs (VA) Mid-Atlantic Mental Illness Research, Education, and Clinical Center (MIRECC) Post-Deployment Mental Health (PDMH) multi-site study examines post-deployment mental health in US military Afghanistan ... Full text Link to item Cite

A Novel Strategy for Continuation ECT in Geriatric Depression: Phase 2 of the PRIDE Study.

Journal Article Am J Psychiatry · November 1, 2016 OBJECTIVE: The randomized phase (phase 2) of the Prolonging Remission in Depressed Elderly (PRIDE) study evaluated the efficacy and tolerability of continuation ECT plus medication compared with medication alone in depressed geriatric patients after a succ ... Full text Link to item Cite

Right Unilateral Ultrabrief Pulse ECT in Geriatric Depression: Phase 1 of the PRIDE Study.

Journal Article Am J Psychiatry · November 1, 2016 OBJECTIVE: The Prolonging Remission in Depressed Elderly (PRIDE) study evaluated the efficacy of right unilateral ultrabrief pulse electroconvulsive therapy (ECT) combined with venlafaxine for the treatment of geriatric depression. METHOD: PRIDE was a two- ... Full text Link to item Cite

Comparative Effectiveness of an Internet-Based Smoking Cessation Intervention Versus Clinic-Based Specialty Care for Veterans.

Journal Article J Subst Abuse Treat · October 2016 INTRODUCTION: The primary objective of this project was to examine the effectiveness of an Internet-based smoking cessation intervention combined with a tele-health medication clinic for nicotine replacement therapy (NRT) compared to referral to clinic-bas ... Full text Link to item Cite

Erratum

Journal Article Alcoholism: Clinical and Experimental Research · August 2016 Full text Cite

Dysregulation of Prefrontal Cortex-Mediated Slow-Evolving Limbic Dynamics Drives Stress-Induced Emotional Pathology.

Journal Article Neuron · July 20, 2016 Circuits distributed across cortico-limbic brain regions compose the networks that mediate emotional behavior. The prefrontal cortex (PFC) regulates ultraslow (<1 Hz) dynamics across these networks, and PFC dysfunction is implicated in stress-related illne ... Full text Link to item Cite

Sexual revictimization among Iraq and Afghanistan war era veterans.

Journal Article Psychiatry Res · June 30, 2016 Research in both civilian and military populations has demonstrated that females who experience childhood sexual abuse (CSA) are more likely to experience sexual assault in adulthood than females who did not experience CSA. Among veteran samples, however, ... Full text Link to item Cite

Opposing effects of traumatic brain injury on excitatory synaptic function in the lateral amygdala in the absence and presence of preinjury stress.

Journal Article J Neurosci Res · June 2016 Traumatic brain injury (TBI) is a leading cause of death and disability among young adults and is highly prevalent among recently deployed military personnel. Survivors of TBI often experience cognitive and emotional deficits, suggesting that long-term eff ... Full text Link to item Cite

Allopregnanolone Levels Are Inversely Associated with Self-Reported Pain Symptoms in U.S. Iraq and Afghanistan-Era Veterans: Implications for Biomarkers and Therapeutics.

Journal Article Pain Med · January 2016 BACKGROUND AND OBJECTIVES: Pain symptoms are common among Iraq/Afghanistan-era veterans, many of whom continue to experience persistent pain symptoms despite multiple pharmacological interventions. Preclinical data suggest that neurosteroids such as allopr ... Full text Open Access Link to item Cite

An exploratory pilot investigation of neurosteroids and self-reported pain in female Iraq/Afghanistan-era Veterans.

Journal Article J Rehabil Res Dev · 2016 Female Veterans are the most rapidly growing segment of new users of the Veterans Health Administration (VHA), and a significant proportion of female Veterans receiving treatment from VHA primary care providers report persistent pain symptoms. Currently, a ... Full text Link to item Cite

Drug use and validity of substance use self-reports in veterans seeking help for posttraumatic stress disorder

Chapter · January 1, 2016 The present study assessed drug use and the validity of self-reports of substance use among help-seeking veterans referred to a specialty clinic for the assessment of posttraumatic stress disorder (PTSD). Patients (n = 341) were asked to provide a urine sa ... Full text Cite

Adolescent Intermittent Alcohol Exposure: Dysregulation of Thrombospondins and Synapse Formation are Associated with Decreased Neuronal Density in the Adult Hippocampus.

Journal Article Alcohol Clin Exp Res · December 2015 BACKGROUND: Adolescent intermittent alcohol exposure (AIE) has profound effects on neuronal function. We have previously shown that AIE causes aberrant hippocampal structure and function that persists into adulthood. However, the possible contributions of ... Full text Link to item Cite

Interaction of CRF and kappa opioid systems on GABAergic neurotransmission in the mouse central amygdala.

Journal Article J Pharmacol Exp Ther · November 2015 The corticotropin-releasing factor (CRF) and kappa-opioid receptor (KOR) systems are both implicated in stress-related behaviors and drug dependence. Although previous studies suggest that antagonism of each system blocks aspects of experimental models of ... Full text Link to item Cite

Functional correlates of military sexual assault in male veterans.

Journal Article Psychol Serv · November 2015 Despite research findings that similar numbers of male and female veterans are affected by military sexual trauma (MST), there has been considerably less research on the effects of MST specific to male veterans. The aim of the present study was to provide ... Full text Link to item Cite

Effect of genetic variation in the nicotinic receptor genes on risk for posttraumatic stress disorder.

Journal Article Psychiatry Res · September 30, 2015 The present study examined the association between genetic variation in the nicotinic receptor gene family (CHRNA2, CHRNA3, CHRNA4, CHRNA5, CHRNA6, CHRNA7, CHRNA9, CHRNA10, CHRNB2, CHRNB3, CHRNB4) and the occurrence of posttraumatic stress disorder (PTSD). ... Full text Link to item Cite

Multicomponent smoking cessation treatment including mobile contingency management in homeless veterans.

Journal Article J Clin Psychiatry · July 2015 INTRODUCTION: Smoking rates are 80% among persons who are homeless, and these smokers have decreased odds of quitting smoking. Little is known about relapse rates among homeless smokers. More information is needed regarding both quit rates and innovative m ... Full text Link to item Cite

Drug use and childhood-, military- and post-military trauma exposure among women and men veterans.

Journal Article Drug Alcohol Depend · July 1, 2015 BACKGROUND: The current study was undertaken to examine whether posttraumatic stress symptoms (PTSS) and depressive symptoms mediated the association between trauma exposure (combat-related trauma and non-combat traumas occurring before, during, and after ... Full text Link to item Cite

Adolescent intermittent alcohol exposure: persistence of structural and functional hippocampal abnormalities into adulthood.

Journal Article Alcohol Clin Exp Res · June 2015 BACKGROUND: Human adolescence is a crucial stage of neurological development during which ethanol (EtOH) consumption is often at its highest. Alcohol abuse during adolescence may render individuals at heightened risk for subsequent alcohol abuse disorders, ... Full text Link to item Cite

The factor structure of psychiatric comorbidity among Iraq/Afghanistan-era veterans and its relationship to violence, incarceration, suicide attempts, and suicidality.

Journal Article Psychiatry Res · December 15, 2014 The present research examined how incarceration, suicide attempts, suicidality, and difficulty controlling violence relate to the underlying factor structure of psychiatric comorbidity among a large sample of Iraq/Afghanistan-era veterans (N=1897). Diagnos ... Full text Link to item Cite

DSM-5 posttraumatic stress disorder: factor structure and rates of diagnosis.

Journal Article J Psychiatr Res · December 2014 Posttraumatic stress disorder (PTSD) is a significant problem among Iraq/Afghanistan-era veterans. To date, however, there has been only limited research on how the recent changes in DSM-5 influence the prevalence and factor structure of PTSD. To address t ... Full text Link to item Cite

Presynaptic BK channels modulate ethanol-induced enhancement of GABAergic transmission in the rat central amygdala nucleus.

Journal Article J Neurosci · October 8, 2014 Large-conductance calcium-activated potassium BK channels are widely expressed in the brain and are involved in the regulation of neuronal functions such as neurotransmitter release. However, their possible role in mediating ethanol-induced GABA release is ... Full text Link to item Cite

Altered neurotransmission in the lateral amygdala in aged human apoE4 targeted replacement mice.

Journal Article Neurobiol Aging · September 2014 The human APOE4 allele is associated with an early age of onset and increased risk of Alzheimer's disease (AD). Apolipoprotein E is secreted as part of a high-density lipoprotein-like particle by glial cells in the brain for the primary purpose of transpor ... Full text Link to item Cite

The impact of social support on psychological distress for U.S. Afghanistan/Iraq era veterans with PTSD and other psychiatric diagnoses.

Journal Article Psychiatry Res · June 30, 2014 This study aimed to examine the degree to which posttraumatic stress disorder (PTSD) affects the relationship between social support and psychological distress for U.S. Afghanistan/Iraq era veterans with and without co-occurring psychiatric disorders. Vete ... Full text Link to item Cite

ISOFLURANE EXPOSURE ENHANCES ETHANOL-RELATED BEHAVIORAL RESPONSES IN ADOLESCENT RATS

Conference ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH · June 1, 2014 Link to item Cite

Amino acids as biomarker candidates for suicidality in male OEF/OIF Veterans: relevance to NMDA receptor modulation and nitric oxide signaling.

Journal Article Mil Med · May 2014 Veteran populations are exposed to multiple stressful events, and suicidality among veterans is a serious problem. Identifying biomarkers of suicidality may enhance detection, prevention, and treatment. Multiple neurotransmitter systems are implicated in t ... Full text Link to item Cite

Regional-specific effects of ovarian hormone loss on synaptic plasticity in adult human APOE targeted replacement mice.

Journal Article PLoS One · 2014 The human apolipoprotein ε4 allele (APOE4) has been implicated as one of the strongest genetic risk factors associated with Alzheimer's disease (AD) and in influencing normal cognitive functioning. Previous studies have demonstrated that mice expressing hu ... Full text Link to item Cite

Static magnetic field modulates excitatory activity in layer II/III pyramidal neurons of the rat motor cortex

Conference International IEEE EMBS Conference on Neural Engineering Ner · December 1, 2013 Recent studies revealed that transcranial stimulation with static magnetic field (SMF) at 0.1-0.15 T results in reduction of neural excitability in the human motor cortex. We explore the mechanisms of this phenomenon with patch-clamp recording in rat brain ... Full text Cite

Long-term modulation of A-type K(+) conductances in hippocampal CA1 interneurons in rats after chronic intermittent ethanol exposure during adolescence or adulthood.

Journal Article Alcohol Clin Exp Res · December 2013 BACKGROUND: Chronic alcohol use, especially exposure to alcohol during adolescence or young adulthood, is closely associated with cognitive deficits that may persist into adulthood. Therefore, it is essential to identify possible neuronal mechanisms underl ... Full text Link to item Cite

Mobile contingency management as an adjunctive smoking cessation treatment for smokers with posttraumatic stress disorder.

Journal Article Nicotine Tob Res · November 2013 INTRODUCTION: Smokers with posttraumatic stress disorder (PTSD) smoke at higher prevalence rates and are more likely to relapse early in a quit attempt. Innovative methods are needed to enhance quit rates, particularly in the early quit period. Web-based c ... Full text Link to item Cite

Binge-pattern ethanol exposure during adolescence, but not adulthood, causes persistent changes in GABAA receptor-mediated tonic inhibition in dentate granule cells.

Journal Article Alcohol Clin Exp Res · July 2013 BACKGROUND: In recent years, it has become clear that acute ethanol (EtOH) affects various neurobiological and behavioral functions differently in adolescent animals than in adults. However, less is known about the long-term neural consequences of chronic ... Full text Link to item Cite

κ-Opioid receptors in the central amygdala regulate ethanol actions at presynaptic GABAergic sites.

Journal Article J Pharmacol Exp Ther · July 2013 Human and animal studies indicate that κ-opioid receptors (KORs) are involved in ethanol drinking and dependence (Xuei et al., 2006; Walker and Koob, 2008; Walker et al., 2011). Using in vitro single-cell recording techniques in mouse brain slices, we exam ... Full text Link to item Cite

The Association of Sleep Duration, Mental Health, and Health Risk Behaviors among U.S. Afghanistan/Iraq Era Veterans.

Journal Article Sleep · July 1, 2013 STUDY OBJECTIVES: Short and long sleep duration have been linked with higher rates of comorbid medical and mental health issues, as well as increased mortality. The current study examined the association between sleep duration, mental health problems, and ... Full text Link to item Cite

DOWNREGULATION OF NEURONAL BK CHANNELS AFTER CHRONIC INTERMITTENT ETHANOL EXPOSURE

Conference ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH · June 1, 2013 Link to item Cite

The auxiliary subunit KChIP2 is an essential regulator of homeostatic excitability.

Journal Article J Biol Chem · May 10, 2013 BACKGROUND: The necessity for, or redundancy of, distinctive KChIP proteins is not known. RESULTS: Deletion of KChIP2 leads to increased susceptibility to epilepsy and to a reduction in IA and increased excitability in pyramidal hippocampal neurons. CONCLU ... Full text Link to item Cite

TARGET SPECIFIC EFFECTS OF NEUROPEPTIDE SYSTEMS IN THE CENTRAL AMYGDALA

Conference ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH · June 1, 2012 Link to item Cite

In the rat, chronic intermittent ethanol exposure during adolescence alters the ethanol sensitivity of tonic inhibition in adulthood.

Journal Article Alcohol Clin Exp Res · February 2012 BACKGROUND: Alcohol drinking by adolescents is a major public health concern. Adolescents tend to drink in a chronic, intermittent, that is, "binge," pattern, and such patterns of ethanol exposure are associated with increased risk of neurotoxicity and the ... Full text Link to item Cite

GABA transport modulates the ethanol sensitivity of tonic inhibition in the rat dentate gyrus.

Journal Article Alcohol · September 2011 In recent years, the effect of ethanol on tonic inhibition mediated by extrasynaptic GABA(A) receptors (GABA(A)Rs) has become a topic of intensive investigation and some controversy. The high ethanol sensitivity of extrasynaptic GABA(A) receptors containin ... Full text Link to item Cite

Public health clinical demonstration project for smoking cessation in american veterans who served since september 11, 2001.

Journal Article J Addict Med · March 2011 OBJECTIVE: The purpose of this clinical demonstration project was to increase the reach of effective treatments, such as pharmacotherapy and telephone or web-based support, by offering these treatments in a low cost and convenient manner to a population of ... Full text Link to item Cite

Progressive loss of synaptic integrity in human apolipoprotein E4 targeted replacement mice and attenuation by apolipoprotein E2.

Journal Article Neuroscience · December 29, 2010 Inheritance of the APOE4 allele is a well established genetic risk factor linked to the development of late onset Alzheimer's disease. As the major lipid transport protein in the central nervous system, apolipoprotein (apo) E plays an important role in the ... Full text Link to item Cite

Dopamine attenuates evoked inhibitory synaptic currents in central amygdala neurons.

Journal Article Eur J Neurosci · December 2010 The central nucleus of the amygdala (CeA) plays a critical role in regulating the behavioral, autonomic and endocrine response to stress. Dopamine (DA) participates in mediating the stress response and DA release is enhanced in the CeA during stressful eve ... Full text Link to item Cite

Correlates of anger and hostility in Iraq and Afghanistan war veterans.

Journal Article Am J Psychiatry · September 2010 OBJECTIVE: As troops return from Iraq and Afghanistan to civilian life, clinicians are starting to grapple with how best to detect those at risk of postdeployment adjustment problems. Data reveal the presence of mental health problems in these soldiers, in ... Full text Link to item Cite

THE INTERACTION BETWEEN ETHANOL AND KAPPA OPIOID SYSTEM IN THE MICE CENTRAL AMYGDALE

Conference ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH · August 10, 2010 Link to item Cite

Exploration of the resilience construct in posttraumatic stress disorder severity and functional correlates in military combat veterans who have served since September 11, 2001.

Journal Article J Clin Psychiatry · July 2010 OBJECTIVE: This study evaluated the relationship between resilience and psychological functioning in military veterans deployed to a region of military conflict in support of Operation Enduring Freedom or Operation Iraqi Freedom. METHOD: 497 military veter ... Full text Link to item Cite

Public health clinical demonstration project for smoking cessation in veterans with posttraumatic stress disorder.

Journal Article Addict Behav · January 2010 Veterans with posttraumatic stress disorder are at high risk for smoking and experience difficulty with smoking cessation. We designed this clinical demonstration project to provide a low-cost, feasibly implemented smoking cessation intervention that would ... Full text Link to item Cite

Prospective study of externalizing and internalizing subtypes of posttraumatic stress disorder and their relationship to mortality among Vietnam veterans.

Journal Article Compr Psychiatry · 2010 Posttraumatic stress disorder (PTSD) can be a complex disorder, and some studies have found that samples of individuals with PTSD contain subtypes that may relate to health outcomes. The goals were to replicate previously identified PTSD subtypes and exami ... Full text Link to item Cite

Neuropeptides modulate compound postsynaptic potentials in basolateral amygdala.

Journal Article Neuroscience · December 29, 2009 Previous behavioral studies have shown that neuropeptides intrinsic to the amygdala formation can alter fear and anxiety states. We have previously shown that the anxiogenic neuropeptide cholecystokinin (CCK) increases inhibitory neurotransmission in basol ... Full text Link to item Cite

Cholecystokinin action on layer 6b neurons in somatosensory cortex.

Journal Article Brain Res · July 28, 2009 Layer 6b in neocortex is a distinct sublamina at the ventral portion of layer 6. Corticothalamic projections arise from 6b neurons, but few studies have examined the functional properties of these cells. In the present study we examined the actions of chol ... Full text Link to item Cite

Cholecystokinin excites interneurons in rat basolateral amygdala.

Journal Article J Neurophysiol · July 2009 The amygdala formation is implicated in generation of emotional states such as anxiety and fear. Many substances that modulate neuronal activity in the amygdala alter anxiety. Cholecystokinin (CCK) is an endogenous neuropeptide that induces anxiety states ... Full text Link to item Cite

POTENTIATION OF CRF SENSITIVITY IN ETHANOL WITHDRAWN RATS: GENDER DIFFERENCES

Conference ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH · June 1, 2009 Link to item Cite

Mu-opioid receptors selectively regulate basal inhibitory transmission in the central amygdala: lack of ethanol interactions.

Journal Article J Pharmacol Exp Ther · January 2009 Endogenous opioid systems are implicated in the actions of ethanol. For example, mu-opioid receptor (MOR) knockout (KO) mice self-administer less alcohol than the genetically intact counterpart wild-type (WT) mice (Roberts et al., 2000). MOR KO mice also e ... Full text Link to item Cite

Preliminary findings from a clinical demonstration project for veterans returning from Iraq or Afghanistan.

Journal Article Mil Med · May 2008 Military veterans are at high risk for nicotine dependence. This clinical demonstration project used invitational letters, referral to the National Cancer Institute's Smoking Quitline, and local Veteran Affairs prescriptions for tobacco cessation to evalua ... Full text Link to item Cite

Cholecystokinin enhances GABAergic inhibitory transmission in basolateral amygdala.

Journal Article Neuropeptides · December 2007 The neuropeptide cholecystokinin (CCK) is anxiogenic in studies of human and animal behavior. As the amygdala formation has been implicated in generation of emotional states such as anxiety, we tested the effect of CCK on spontaneous synaptic events in the ... Full text Link to item Cite

Post-Traumatic Stress Disorder and Substance Use Disorders

Journal Article · December 1, 2007 There is a high incidence of exposure to traumatic experiences in the U.S. general population. The majority of the population at some time in their lives experience a distressing and traumatic event. Two common psychiatric conditions that occur post-trauma ... Full text Cite

Differential sensitivity of GABA A receptor-mediated IPSCs to cannabinoids in hippocampal slices from adolescent and adult rats.

Journal Article J Neurophysiol · September 2007 The impairment of learning and memory is one of the most powerful and least understood effects of marijuana although the hippocampal formation appears to be one CNS region mediating these effects. We have shown that systemic injection of Delta9-tetrahydroc ... Full text Link to item Cite

A placebo-controlled trial of bupropion SR in the treatment of chronic posttraumatic stress disorder.

Journal Article J Clin Psychopharmacol · April 2007 OBJECTIVE: Although selective serotonin reuptake inhibitors have been the most empirically studied pharmacotherapy for posttraumatic stress disorder (PTSD), a need remains for the investigation of additional pharmacological agents in the treatment of PTSD. ... Full text Link to item Cite

Neurosteroid modulation of GABAergic neurotransmission in the central amygdala: a role for NMDA receptors.

Journal Article Neurosci Lett · March 26, 2007 The neurosteroid 3alpha-hydroxy-5alpha-pregnan-20-one (allopregnanolone or ALLO) positively modulates GABA(A) receptors, an action that may contribute to the anxiolytic effects of ALLO. Recent evidence suggests that ALLO's anxiolytic effects appear to be m ... Full text Link to item Cite

Presynaptic delta opioid receptors regulate ethanol actions in central amygdala.

Journal Article J Pharmacol Exp Ther · February 2007 Endogenous opioid systems are implicated in the reinforcing effects of ethanol consumption. For example, delta opioid receptor (DOR) knockout (KO) mice show greater ethanol consumption than wild-type (WT) mice (Roberts et al., 2001). To explore the neurobi ... Full text Link to item Cite

Post-traumatic Stress Disorder and Substance Use Disorders

Chapter · December 22, 2006 There is a high incidence of exposure to traumatic experiences in the U.S. general population. The majority of the population at some time in their lives experience a distressing and traumatic event. Two common psychiatric conditions that occur post-trauma ... Full text Cite

Ethanol effects on polysynaptic, pathways from basolateral amygdala to central amygdala.

Conference ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH · May 1, 2005 Link to item Cite

Human apoE4-targeted replacement mice display synaptic deficits in the absence of neuropathology.

Journal Article Neurobiol Dis · March 2005 The human APOE*4 allele is associated with an early age of onset and increased risk of Alzheimer's disease (AD). Long before the onset of AD, cognitive deficits can be identified in APOE*4 carriers. We examined neurons in the lateral amygdala of young apol ... Full text Link to item Cite

Ethanol augments GABAergic transmission in the central amygdala via CRF1 receptors.

Journal Article Science · March 5, 2004 The central amygdala (CeA) plays a role in the relationship among stress, corticotropin-releasing factor (CRF), and alcohol abuse. In whole-cell recordings, both CRF and ethanol enhanced gamma-aminobutyric acid-mediated (GABAergic) neurotransmission in CeA ... Full text Link to item Cite

Differential actions of diazepam and zolpidem in basolateral and central amygdala nuclei.

Journal Article Neuropharmacology · January 2004 Benzodiazepines are among the most widely prescribed therapeutic agents, having anxiolytic, anticonvulsant, sedative/hypnotic, and amnestic properties (Mehta and Ticku, Brain Res. Rev. 29 (1999) 196). Recent research indicates that these disparate actions ... Full text Link to item Cite

Ambulatory monitoring and physical health report in Vietnam veterans with and without chronic posttraumatic stress disorder.

Journal Article J Trauma Stress · August 2003 This study investigated the associations among PTSD, ambulatory cardiovascular monitoring, and physical health self-reports in 117 male Vietnam combat veterans (61 with PTSD and 56 without PTSD). PTSD was associated with health symptoms and number of curre ... Full text Link to item Cite

Ethanol increases GABAergic transmission at both pre- and postsynaptic sites in rat central amygdala neurons.

Journal Article Proc Natl Acad Sci U S A · February 18, 2003 We examined the interaction of ethanol with the gamma-aminobutyric acid (GABA)ergic system in neurons of slices of the rat central amygdala nucleus (CeA), a brain region thought to be critical for the reinforcing effects of ethanol. Brief superfusion of 11 ... Full text Link to item Cite

Protein phosphatases mediate depotentiation induced by high-intensity theta-burst stimulation.

Journal Article J Neurophysiol · February 2003 We have previously reported that varying stimulus intensity produces qualitatively different types of synaptic plasticity in area CA1 of hippocampal slices: brief low-intensity (LI) theta-burst (TB) stimuli induce long-term potentiation (LTP), but if the s ... Full text Link to item Cite

Three- to four-year follow-up to an open trial of nefazodone for combat-related posttraumatic stress disorder.

Journal Article Ann Clin Psychiatry · December 2002 Multiyear (37-51 months) follow-up data was obtained on patients who had participated in an open label trial of nefazodone that originally showed nefazodone may be useful for symptom management in posttraumatic stress disorder (PTSD) patients. Ten patients ... Full text Link to item Cite

Violence and hostility among families of Vietnam veterans with combat-related posttraumatic stress disorder.

Journal Article Violence Vict · August 2002 The current study provides a portrait of emotional-behavioral functioning within a small sample of Vietnam veterans with combat-related posttraumatic stress disorder (PTSD), their partners, and older adolescent and adult children. Veterans, their partners ... Full text Link to item Cite

Properties of the pathways from the lateral amygdal nucleus to basolateral nucleus and amygdalostriatal transition area.

Journal Article J Neurophysiol · May 2002 Studies have revealed that the amygdala formation is involved in emotional learning, attention, and autonomic functions. Although intra-amygdala connections have been described anatomically, the functional characteristics of these connections are not well ... Full text Link to item Cite

Personality traits and pathology in older and younger incarcerated women.

Journal Article J Clin Psychol · April 2002 Personality disorders were examined in 157 incarcerated women, using the Schedule for Nonadaptive and Adaptive Personality (SNAP; Clark, 1996) to assess 10 Diagnostic and Statistical Manual of Mental Disorders, Third Edition, Revised (DSM-III-R; American P ... Full text Link to item Cite

MMPI-2 profiles of Gulf and Vietnam combat veterans with chronic posttraumatic stress disorder.

Journal Article J Clin Psychol · April 2002 The current study examined service era differences in a sample of 172 Gulf and Vietnam outpatient veterans with combat-related posttraumatic stress disorder (PTSD). Participants completed the MMPI-2 and several additional self-report measures of symptom se ... Full text Link to item Cite

Magnitude and duration of cardiovascular responses to anger in Vietnam veterans with and without posttraumatic stress disorder.

Journal Article J Consult Clin Psychol · February 2002 This study investigated the cardiovascular responses to a relived anger task in 118 male Vietnam combat veterans (62 with posttraumatic stress disorder [PTSD] and 56 without PTSD). Participants completed standardized diagnostic measures, hostility measures ... Full text Link to item Cite

Role of NMDA, non-NMDA, and GABA receptors in signal propagation in the amygdala formation.

Journal Article J Neurophysiol · September 2001 Although the synaptic physiology of the amygdala has been studied with single neuron recordings, the properties of the networks between the various nuclei have resisted characterization because of the limitations of field recording in a neuronally diffuse ... Full text Link to item Cite

A preliminary study of bupropion sustained-release for smoking cessation in patients with chronic posttraumatic stress disorder.

Journal Article J Clin Psychopharmacol · February 2001 This study was conducted to evaluate the effect of bupropion sustained-release (SR) on smoking cessation in patients with chronic posttraumatic stress disorder (PTSD). Fifteen veterans with chronic PTSD who desired to stop smoking enrolled in a 12-week dou ... Full text Link to item Cite

Drug use and validity of substance use self-reports in veterans seeking help for posttraumatic stress disorder.

Journal Article J Consult Clin Psychol · October 2000 The present study assessed drug use and the validity of self-reports of substance use among help-seeking veterans referred to a specialty clinic for the assessment of posttraumatic stress disorder (PTSD). Patients (n = 341) were asked to provide a urine sa ... Link to item Cite

Ambulatory cardiovascular activity in Vietnam combat veterans with and without posttraumatic stress disorder.

Journal Article J Consult Clin Psychol · April 2000 The present study investigated the relationship between daily diary affect ratings and ambulatory cardiovascular activity in 117 male Vietnam combat veterans (61 with posttraumatic stress disorder [PTSD] and 56 without PTSD). Participants completed 12-14 h ... Full text Link to item Cite

NMDA-Receptor-dependent synaptic activation of voltage-dependent calcium channels in basolateral amygdala.

Journal Article J Neurophysiol · February 2000 Afferent stimulation of pyramidal cells in the basolateral amygdala produced mixed excitatory postsynaptic potentials (EPSPs) mediated by N-methyl-D-aspartate (NMDA) and non-NMDA glutamate receptors during whole cell current-clamp recordings. In the presen ... Full text Link to item Cite

Interpersonal hostility and violence in vietnam combat veterans with chronic posttraumatic stress disorder: A review of theoretical models and empirical evidence

Journal Article Aggression and Violent Behavior · January 1, 2000 There is strong evidence that anger and violence are prevalent problems in Vietnam combat veterans with posttraumatic stress disorder, and a summary of relevant empirical studies is presented. However, the pathways responsible for development and perpetuat ... Full text Cite

Reduction of voltage-dependent currents by ethanol contributes to inhibition of NMDA receptor-mediated excitatory synaptic transmission.

Journal Article Brain Res · January 16, 1999 Previous studies have shown inhibitory effects of EtOH on NMDA receptor-mediated synaptic transmission in several brain regions. We examined this effect of EtOH under both current clamp and voltage clamp conditions in the basolateral amygdala because of th ... Full text Link to item Cite

Magnesium-dependent inhibition of N-methyl-D-aspartate receptor-mediated synaptic transmission by ethanol.

Journal Article J Pharmacol Exp Ther · December 1998 Previous studies have indicated that ethanol (EtOH) has a relatively specific effect on excitatory synaptic transmission by inhibiting function of the N-methyl-D-aspartate receptor. We have found that EtOH potently inhibits N-methyl-D-aspartate-mediated sy ... Link to item Cite

Health status, somatization, and severity of posttraumatic stress disorder in Vietnam combat veterans with posttraumatic stress disorder.

Journal Article Am J Psychiatry · November 1998 OBJECTIVE: A two-part study was conducted to examine the health status of Vietnam veterans with posttraumatic stress disorder (PTSD). In part 1, veterans with and without PTSD were compared on health behaviors and on self-reported and physician-rated healt ... Full text Link to item Cite

Open trial of nefazodone for combat-related posttraumatic stress disorder.

Journal Article J Clin Psychiatry · September 1998 BACKGROUND: Because of its ability to block 5-HT2 receptors postsynaptically and inhibit 5-HT reuptake presynaptically and/or its enhancement of sleep quality, nefazodone may be useful for symptom management in posttraumatic stress disorder (PTSD) patients ... Full text Link to item Cite

The use of flumazenil in the anxious and benzodiazepine-dependent ECT patient.

Journal Article J ECT · March 1998 Many patients who receive electroconvulsive therapy (ECT) are benzodiazepine dependent or are anxious and require benzodiazepine drugs. Because these agents may diminish the therapeutic effectiveness of ECT, we explored the dosing, safety, and efficacy of ... Link to item Cite

Interpersonal violence and its correlates in Vietnam veterans with chronic posttraumatic stress disorder.

Journal Article J Clin Psychol · December 1997 Two studies were conducted to investigate interpersonal violence in Vietnam veterans with posttraumatic stress disorder (PTSD). In study one, combat veterans with PTSD reported significantly greater occurrence of violent behaviors over the past year (22 ac ... Full text Link to item Cite

Chronic posttraumatic stress disorder and chronic pain in Vietnam combat veterans.

Journal Article J Psychosom Res · October 1997 A study was conducted to investigate chronic pain patterns in Vietnam veterans with posttraumatic stress disorder (PTSD). Combat veterans with PTSD completed standardized PTSD severity, pain, somatization, and depression measures. Of 129 consecutive out-pa ... Full text Link to item Cite

Post-ictal depression transiently inhibits induction of LTP in area CA1 of the rat hippocampal slice.

Journal Article Epilepsy Res · May 1997 We tested the effects of electrographic seizures (EGSs) elicited in a remote site (area CA3) on the induction of long-term potentiation (LTP) in area CA1 of the rat hippocampal slice. Induction of LTP was inhibited only when the LTP-inducing stimulus was d ... Full text Link to item Cite

Prevalence and correlates of heavy smoking in Vietnam veterans with chronic posttraumatic stress disorder.

Journal Article Addict Behav · 1997 A study was conducted to investigate smoking patterns in 445 Vietnam veterans with and without posttraumatic stress disorder (PTSD). Combat veterans with PTSD reported similar occurrence of smoking (53%) compared to combat veterans without PTSD (45%). For ... Full text Link to item Cite

Cost effectiveness of maintenance ECT.

Journal Article Convuls Ther · December 1995 Link to item Cite

Induction and reversal of long-term potentiation by low- and high-intensity theta pattern stimulation.

Journal Article J Neurosci · July 1995 Reversal of long-term potentiation by low-frequency stimulation is often referred to as depotentiation. However, it is not clear whether depotentiation induced by low-frequency stimulation and long-term depression (LTD) induced by similar stimuli are disti ... Full text Link to item Cite

Induction and reversal of long-term potentiation by low- and high-intensity theta pattern stimulation

Journal Article Journal of Neuroscience · 1995 Reversal of long-term potentiation by low-frequency stimulation is often referred to as depotentiation. However, it is not clear whether depotentiation induced by low-frequency stimulation and long-term depression (LTD) induced by similar stimuli are disti ... Cite

Voltage-dependent effects of opioid peptides on hippocampal CA3 pyramidal neurons in vitro.

Journal Article J Neurosci · February 1994 Opioid peptides, and especially the dynorphins, have been localized to several circuits in the CA3 hippocampal region, yet electrophysiological studies often find mixed effects of opiates on the excitability of CA3 neurons. Reasoning that these mixed effec ... Full text Link to item Cite

Seizure-like activity disrupts LTP in vitro.

Journal Article Neurosci Lett · November 26, 1993 Amnesia is one of the most common consequences of seizures. We modelled this phenomenon in the in vitro hippocampal slice preparation by examining effects of seizure-like activity on long-term potentiation (LTP). LTP is an expression of neuronal plasticity ... Full text Link to item Cite

Ethanol diminishes a voltage-dependent K+ current, the M-current, in CA1 hippocampal pyramidal neurons in vitro.

Journal Article Brain Res · May 21, 1990 Previous in vivo studies showed that systemic ethanol enhanced hippocampal neuronal responses to iontophoretically applied acetylcholine and somatostatin while having little or no effect on responses to other transmitters. We previously reported that these ... Full text Link to item Cite

Somatostatin immunohistochemistry of hippocampal slices with lucifer yellow-stained pyramidal neurons responding to somatostatin.

Journal Article Regul Pept · April 24, 1990 We have combined electrophysiology and immunohistochemistry to study the somatostatin (SS) innervation of neurons in the rat hippocampal slice. After recording the intracellular response of a pyramidal CA1 neuron in vitro to SS, Lucifer Yellow was injected ... Full text Link to item Cite

Enkephalin analogues depress synaptic potentials in rat dentate granule cells recorded intracellularly in vitro.

Journal Article Neurosci Lett · August 15, 1988 Enkephalin analogues were superfused onto hippocampal slices during intracellular recording of dentate granule cells. The enkephalins elicited either weak depolarizations, weak hyperpolarizations, or no effect on membrane potential, in about equal numbers ... Full text Link to item Cite

Somatostatin augments the M-current in hippocampal neurons.

Journal Article Science · January 15, 1988 Immunocytochemical and electrophysiological evidence suggests that somatostatin may be a transmitter in the hippocampus. To characterize the ionic mechanisms underlying somatostatin effects, voltage-clamp and current-clamp studies on single CA1 pyramidal n ... Full text Link to item Cite

Effect of blood pressure on A2 noradrenergic neurons.

Journal Article Brain Res · July 8, 1985 Single-unit recordings of A2 noradrenergic neurons were obtained in urethane-anesthetized rats. Norepinephrine-induced elevations in arterial pressure produced small decreases in the discharge rate of the cells; this effect was not observed in animals with ... Full text Link to item Cite

Alpha-receptor mediated inhibition of A2 noradrenergic neurons.

Journal Article Brain Res · October 3, 1983 A series of adrenergic agonists and antagonists was applied by iontophoresis in the vicinity of noradrenergic neurons in the nucleus commissuralis of the rat. Alpha-2 receptor-mediated inhibition of these neurons was observed with single-unit recording tec ... Full text Link to item Cite

An electrophysiological study of the forebrain projection of nucleus commissuralis: preliminary identification of presumed A2 catecholaminergic neurons.

Journal Article Brain Res · March 21, 1983 Using a double-labeling technique (HRP combined with catecholamine fluorescence), up to 80% of all CA-containing neurons visualized in the nucleus commissuralis were found to project to or through the median forebrain bundle area (MFB). In addition at leas ... Full text Link to item Cite