Skip to main content
construction release_alert
Scholars@Duke will be undergoing maintenance April 11-15. Some features may be unavailable during this time.
cancel

Posttraumatic stress disorder, trauma, and accelerated biological aging among post-9/11 veterans.

Publication ,  Journal Article
Bourassa, KJ; Garrett, ME; Caspi, A; Dennis, M; Hall, KS; Moffitt, TE; Taylor, GA; VA Mid Atlantic MIRECC Workgroup, ; Ashley-Koch, AE ...
Published in: Transl Psychiatry
January 6, 2024

People who experience trauma and develop posttraumatic stress disorder (PTSD) are at increased risk for poor health. One mechanism that could explain this risk is accelerated biological aging, which is associated with the accumulation of chronic diseases, disability, and premature mortality. Using data from 2309 post-9/11 United States military veterans who participated in the VISN 6 MIRECC's Post-Deployment Mental Health Study, we tested whether PTSD and trauma exposure were associated with accelerated rate of biological aging, assessed using a validated DNA methylation (DNAm) measure of epigenetic aging-DunedinPACE. Veterans with current PTSD were aging faster than those who did not have current PTSD, β = 0.18, 95% CI [0.11, 0.27], p < .001. This effect represented an additional 0.4 months of biological aging each year. Veterans were also aging faster if they reported more PTSD symptoms, β = 0.13, 95% CI [0.09, 0.16], p < 0.001, or higher levels of trauma exposure, β = 0.09, 95% CI [0.05, 0.13], p < 0.001. Notably, veterans with past PTSD were aging more slowly than those with current PTSD, β = -0.21, 95% CI [-0.35, -0.07], p = .003. All reported results accounted for age, gender, self-reported race/ethnicity, and education, and remained when controlling for smoking. Our findings suggest that an accelerated rate of biological aging could help explain how PTSD contributes to poor health and highlights the potential benefits of providing efficacious treatment to populations at increased risk of trauma and PTSD.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Transl Psychiatry

DOI

EISSN

2158-3188

Publication Date

January 6, 2024

Volume

14

Issue

1

Start / End Page

4

Location

United States

Related Subject Headings

  • Veterans
  • Stress Disorders, Post-Traumatic
  • Humans
  • Educational Status
  • DNA Methylation
  • Aging
  • 5202 Biological psychology
  • 3209 Neurosciences
  • 3202 Clinical sciences
  • 1701 Psychology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Bourassa, K. J., Garrett, M. E., Caspi, A., Dennis, M., Hall, K. S., Moffitt, T. E., … Kimbrel, N. A. (2024). Posttraumatic stress disorder, trauma, and accelerated biological aging among post-9/11 veterans. Transl Psychiatry, 14(1), 4. https://doi.org/10.1038/s41398-023-02704-y
Bourassa, Kyle J., Melanie E. Garrett, Avshalom Caspi, Michelle Dennis, Katherine S. Hall, Terrie E. Moffitt, Gregory A. Taylor, et al. “Posttraumatic stress disorder, trauma, and accelerated biological aging among post-9/11 veterans.Transl Psychiatry 14, no. 1 (January 6, 2024): 4. https://doi.org/10.1038/s41398-023-02704-y.
Bourassa KJ, Garrett ME, Caspi A, Dennis M, Hall KS, Moffitt TE, et al. Posttraumatic stress disorder, trauma, and accelerated biological aging among post-9/11 veterans. Transl Psychiatry. 2024 Jan 6;14(1):4.
Bourassa, Kyle J., et al. “Posttraumatic stress disorder, trauma, and accelerated biological aging among post-9/11 veterans.Transl Psychiatry, vol. 14, no. 1, Jan. 2024, p. 4. Pubmed, doi:10.1038/s41398-023-02704-y.
Bourassa KJ, Garrett ME, Caspi A, Dennis M, Hall KS, Moffitt TE, Taylor GA, VA Mid Atlantic MIRECC Workgroup, Ashley-Koch AE, Beckham JC, Kimbrel NA. Posttraumatic stress disorder, trauma, and accelerated biological aging among post-9/11 veterans. Transl Psychiatry. 2024 Jan 6;14(1):4.

Published In

Transl Psychiatry

DOI

EISSN

2158-3188

Publication Date

January 6, 2024

Volume

14

Issue

1

Start / End Page

4

Location

United States

Related Subject Headings

  • Veterans
  • Stress Disorders, Post-Traumatic
  • Humans
  • Educational Status
  • DNA Methylation
  • Aging
  • 5202 Biological psychology
  • 3209 Neurosciences
  • 3202 Clinical sciences
  • 1701 Psychology