Scholars@Duke
Shiva Kumar Das

Shiva Kumar Das

Adjunct Professor in the Department of Radiation Oncology
Radiation Oncology
shiva.das@duke.edu
Box 3295 Med Ctr, Durham, NC 27710
04216 Hosp South, Durham, NC 27710

Selected Publications

Using the TURF Framework to Design an Enhanced Dosimetry Quality Assurance Checklist in an Academic Medical Center

Conference Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) · January 1, 2023 Academic radiation oncology centers have a long history of developing in-house quality assurance (QA) checklists to promote patient safety. These checklists are designed without utilizing formal human-computer interaction methods and are deployed without r ... Full text Cite

Organs at Risk Considerations for Thoracic Stereotactic Body Radiation Therapy: What Is Safe for Lung Parenchyma?

Journal Article Int J Radiat Oncol Biol Phys · May 1, 2021 PURPOSE: Stereotactic body radiation therapy (SBRT) has become the standard of care for inoperable early-stage non-small cell lung cancer and is often used for recurrent lung cancer and pulmonary metastases. Radiation-induced lung toxicity (RILT), includin ... Full text Link to item Cite

Evaluation of a commercial DIR platform for contour propagation in prostate cancer patients treated with IMRT/VMAT.

Journal Article J Appl Clin Med Phys · February 2020 PURPOSE: To assess the performance and limitations of contour propagation with three commercial deformable image registration (DIR) algorithms using fractional scans of CT-on-rails (CTOR) and Cone Beam CT (CBCT) in image guided prostate therapy patients tr ... Full text Link to item Cite

The Impact of Set-Up Uncertainty on Dose-Response Estimates.

Journal Article Int J Radiat Oncol Biol Phys · November 1, 2019 Full text Link to item Cite

Human Error Bowtie Analysis to Enhance Patient Safety in Radiation Oncology.

Journal Article Pract Radiat Oncol · November 2019 PURPOSE: Ensuring safety within RT is of paramount importance. To further support and augment patient safety efforts, the purpose of this research was to test and refine a robust methodology for analyzing human errors that defeat individual controls within ... Full text Link to item Cite

Task Group 174 Report: Utilization of [18 F]Fluorodeoxyglucose Positron Emission Tomography ([18 F]FDG-PET) in Radiation Therapy.

Journal Article Med Phys · October 2019 The use of positron emission tomography (PET) in radiation therapy (RT) is rapidly increasing in the areas of staging, segmentation, treatment planning, and response assessment. The most common radiotracer is 18 F-fluorodeoxyglucose ([18 F]FDG), a glucose ... Full text Open Access Link to item Cite

Using Artificial Intelligence to Improve the Quality and Safety of Radiation Therapy.

Journal Article J Am Coll Radiol · September 2019 Within artificial intelligence, machine learning (ML) efforts in radiation oncology have augmented the transition from generalized to personalized treatment delivery. Although their impact on quality and safety of radiation therapy has been limited, they a ... Full text Link to item Cite

Association of Interim FDG-PET Imaging During Chemoradiation for Squamous Anal Canal Carcinoma With Recurrence.

Journal Article Int J Radiat Oncol Biol Phys · November 15, 2018 PURPOSE: Imaging parameters from 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET) before and after chemoradiation therapy (CRT) for anal canal cancer correlate with clinical outcomes. This prospective, hypothesis-generating pilot study inv ... Full text Link to item Cite

Fitting NTCP models to SBRT dose and carotid blowout syndrome data.

Journal Article Med Phys · October 2018 PURPOSE: To estimate the radiobiological parameters of three popular NTCP models, which describe the dose-response relations of carotid blowout syndrome (CBOS) after stereotactic body radiotherapy (SBRT). To evaluate the goodness-of-fit and the correlation ... Full text Link to item Cite

Correlation of Regional Lung Ventilation and Gas Transfer to Red Blood Cells: Implications for Functional-Avoidance Radiation Therapy Planning.

Journal Article Int J Radiat Oncol Biol Phys · August 1, 2018 PURPOSE: To investigate the degree to which lung ventilation and gas exchange are regionally correlated, using the emerging technology of hyperpolarized (HP)-129Xe magnetic resonance imaging (MRI). METHODS AND MATERIALS: Hyperpolarized-129Xe MRI studies we ... Full text Link to item Cite

Redefining and reinvigorating the role of physics in clinical medicine: A Report from the AAPM Medical Physics 3.0 Ad Hoc Committee.

Journal Article Med Phys · July 10, 2018 Derived from 2 yr of deliberations and community engagement, Medical Physics 3.0 (MP3.0) is an effort commissioned by the American Association of Physicists in Medicine (AAPM) to devise a framework of strategies by which medical physicists can maintain and ... Full text Link to item Cite

How Advances in Imaging Will Affect Precision Radiation Oncology.

Journal Article Int J Radiat Oncol Biol Phys · June 1, 2018 Radiation oncology is 1 of the most structured disciplines in medicine. It is of a highly technical nature with reliance on robotic systems to deliver intervention, engagement of diverse expertise, and early adoption of digital approaches to optimize and e ... Full text Link to item Cite

Promoting safety mindfulness: Recommendations for the design and use of simulation-based training in radiation therapy

Journal Article Advances in Radiation Oncology · April 1, 2018 There is a need to better prepare radiation therapy (RT) providers to safely operate within the health information technology (IT) sociotechnical system. Simulation-based training has been preemptively used to yield meaningful improvements during providers ... Full text Cite

Fitting NTCP models to bladder doses and acute urinary symptoms during post-prostatectomy radiotherapy.

Journal Article Radiat Oncol · February 2, 2018 BACKGROUND: To estimate the radiobiological parameters of three popular normal tissue complication probability (NTCP) models, which describe the dose-response relations of bladder regarding different acute urinary symptoms during post-prostatectomy radioth ... Full text Link to item Cite

Developing and assessing electronic checklists for safety mindfulness, workload, and performance.

Journal Article Pract Radiat Oncol · 2018 PURPOSE: The aim of this study is to propose a set of innovative principles for the effective design of electronic checklists to enhance safety mindfulness (a specific safety mindful mindset that offers the opportunity to operate more preemptively during r ... Full text Link to item Cite

Imaging Radiation-Induced Normal Tissue Injury to Quantify Regional Dose Response.

Journal Article Semin Radiat Oncol · October 2017 Noninvasive imaging has and will continue to play a pivotal role in the assessment of radiation-induced normal tissue toxicity. In this review, we will examine key literature regarding the use of anatomic and physiological imaging in relation to radiation- ... Full text Link to item Cite

Assessment of PlanIQ Feasibility DVH for head and neck treatment planning.

Journal Article J Appl Clin Med Phys · September 2017 INTRODUCTION: Designing a radiation plan that optimally delivers both target coverage and normal tissue sparing is challenging. There are limited tools to determine what is dosimetrically achievable and frequently the experience of the planner/physician is ... Full text Link to item Cite

Noninvasive measurement of tissue blood oxygenation with Cerenkov imaging during therapeutic radiation delivery.

Journal Article Opt Lett · August 15, 2017 Tumor tissue oxygenation significantly affects the outcome of radiotherapy. Real-time monitoring of tumor hypoxia is highly desirable for effective radiotherapy, and is the basis for improved treatment because hypoxic tumor cells are more resistant to radi ... Full text Open Access Link to item Cite

Dose-volume toxicity modeling for de-intensified chemo-radiation therapy for HPV-positive oropharynx cancer.

Journal Article Radiother Oncol · August 2017 BACKGROUND AND PURPOSE: The aim is to determine the radiobiological parameters of four popular normal tissue complication probability (NTCP) models that describe the dose-response relations of salivary glands and pharyngeal constrictors to the severity of ... Full text Link to item Cite

Dosimetric Predictors of Patient-Reported Xerostomia and Dysphagia With Deintensified Chemoradiation Therapy for HPV-Associated Oropharyngeal Squamous Cell Carcinoma.

Journal Article Int J Radiat Oncol Biol Phys · August 1, 2017 PURPOSE/OBJECTIVE(S): To estimate the association between different dose-volume metrics of the salivary glands and pharyngeal constrictors with patient reported severity of xerostomia/dysphagia in the setting of deintensified chemoradiation therapy (CRT). ... Full text Link to item Cite

Toward a standard for the evaluation of PET-Auto-Segmentation methods following the recommendations of AAPM task group No. 211: Requirements and implementation.

Journal Article Med Phys · August 2017 PURPOSE: The aim of this paper is to define the requirements and describe the design and implementation of a standard benchmark tool for evaluation and validation of PET-auto-segmentation (PET-AS) algorithms. This work follows the recommendations of Task G ... Full text Link to item Cite

Early cardiac perfusion defects after left-sided radiation therapy for breast cancer: is there a volume response?

Journal Article Breast Cancer Res Treat · July 2017 PURPOSE: Cardiac single-photon emission computed tomography (SPECT) is often used to identify defects in myocardial perfusion due to atherosclerotic coronary artery disease. It was also used in studies to evaluate radiation therapy (RT)-associated cardiac ... Full text Link to item Cite

Classification and evaluation strategies of auto-segmentation approaches for PET: Report of AAPM task group No. 211.

Journal Article Med Phys · June 2017 PURPOSE: The purpose of this educational report is to provide an overview of the present state-of-the-art PET auto-segmentation (PET-AS) algorithms and their respective validation, with an emphasis on providing the user with help in understanding the chall ... Full text Link to item Cite

Integration of PET/MR Hybrid Imaging into Radiation Therapy Treatment.

Journal Article Magn Reson Imaging Clin N Am · May 2017 Hybrid PET/MR imaging is in early development for treatment planning. This article briefly reviews research and clinical applications of PET/MR imaging in radiation oncology. With improvements in workflow, more specific tracers, and fast and robust acquisi ... Full text Link to item Cite

Utility of Deep Inspiration Breath Hold for Left-Sided Breast Radiation Therapy in Preventing Early Cardiac Perfusion Defects: A Prospective Study.

Conference Int J Radiat Oncol Biol Phys · April 1, 2017 PURPOSE: To evaluate early cardiac single photon computed tomography (SPECT) findings after left breast/chest wall postoperative radiation therapy (RT) in the setting of deep inspiration breath hold (DIBH). METHODS AND MATERIALS: We performed a prospective ... Full text Link to item Cite

TET2 binds the androgen receptor and loss is associated with prostate cancer.

Journal Article Oncogene · April 2017 Genetic alterations associated with prostate cancer (PCa) may be identified by sequencing metastatic tumour genomes to identify molecular markers at this lethal stage of disease. Previously, we characterized somatic alterations in metastatic tumours in the ... Full text Link to item Cite

Evaluation of PET/MRI for tumor volume delineation for head and neck cancer

Journal Article Frontiers in Oncology · January 23, 2017 Introduction: Computed tomography (CT), combined positron emitted tomography and CT (PET/CT), and magnetic resonance imaging (MRI) are commonly used in head and neck radiation planning. Hybrid PET/MRI has garnered attention for potential added value in can ... Full text Cite

Palliative thoracic radiotherapy in advanced lung cancer: A single institution experience.

Journal Article Indian J Cancer · 2017 BACKGROUND: Majority of patients of lung cancer present with locally advanced or metastatic disease, where systemic therapy is the treatment of choice. Many of these patients have local symptoms due to thoracic disease, wherein radiotherapy is proven to be ... Full text Link to item Cite

Welcome to our new publisher: Wiley.

Journal Article Med Phys · January 2017 Full text Link to item Cite

Simple Factors Associated With Radiation-Induced Lung Toxicity After Stereotactic Body Radiation Therapy of the Thorax: A Pooled Analysis of 88 Studies.

Conference Int J Radiat Oncol Biol Phys · August 1, 2016 PURPOSE: To study the risk factors for radiation-induced lung toxicity (RILT) after stereotactic body radiation therapy (SBRT) of the thorax. METHODS AND MATERIALS: Published studies on lung toxicity in patients with early-stage non-small cell lung cancer ... Full text Link to item Cite

Helical tomotherapy for bilateral breast cancer: Clinical experience.

Journal Article Breast · August 2016 UNLABELLED: We report our initial clinical experience with using Helical tomotherapy to irradiate the bilateral breasts/chest-wall and regional nodes. METHODS: The records of patients who received bilateral irradiation of the breast/chest-wall and regional ... Full text Link to item Cite

Cerium Oxide Nanoparticles: A Potential Medical Countermeasure to Mitigate Radiation-Induced Lung Injury in CBA/J Mice.

Journal Article Radiat Res · May 2016 Cerium oxide nanoparticles (CNPs) have a unique surface regenerative property and can efficiently control reactive oxygen/nitrogen species. To determine whether treatment with CNPs can mitigate the delayed effects of lung injury after acute radiation expos ... Full text Link to item Cite

Technology based strategies to enhance the therapeutic ratio

Chapter · January 1, 2016 The general purpose of technology is to enable the accomplishment of new objectives or make current objectives easier and more attainable. In radiation oncology, the ultimate objective is to maximize tumor control while minimizing normal tissue complicatio ... Full text Cite

Phase 1 Dose Escalation Study of Accelerated Radiation Therapy With Concurrent Chemotherapy for Locally Advanced Lung Cancer.

Journal Article Int J Radiat Oncol Biol Phys · December 1, 2015 PURPOSE: To determine the maximum tolerated dose of radiation therapy (RT) given in an accelerated fashion with concurrent chemotherapy using intensity modulated RT. METHODS AND MATERIALS: Patients with locally advanced lung cancer (non-small cell and smal ... Full text Link to item Cite

Novel Manganese-Porphyrin Superoxide Dismutase-Mimetic Widens the Therapeutic Margin in a Preclinical Head and Neck Cancer Model.

Journal Article Int J Radiat Oncol Biol Phys · November 15, 2015 PURPOSE: To test the effects of a novel Mn porphyrin oxidative stress modifier, Mn(III) meso-tetrakis(N-n-butoxyethylpyridinium-2-yl)porphyrin (MnBuOE), for its radioprotective and radiosensitizing properties in normal tissue versus tumor, respectively. ME ... Full text Open Access Link to item Cite

A 2-Year Randomized Controlled Trial of Human Caloric Restriction: Feasibility and Effects on Predictors of Health Span and Longevity.

Journal Article J Gerontol A Biol Sci Med Sci · September 2015 BACKGROUND: Caloric restriction (CR), energy intake reduced below ad libitum (AL) intake, increases life span in many species. The implications for humans can be clarified by randomized controlled trials of CR. METHODS: To determine CR's feasibility, safet ... Full text Link to item Cite

Semiautomated head-and-neck IMRT planning using dose warping and scaling to robustly adapt plans in a knowledge database containing potentially suboptimal plans.

Journal Article Med Phys · August 2015 PURPOSE: Prior work by the authors and other groups has studied the creation of automated intensity modulated radiotherapy (IMRT) plans of equivalent quality to those in a patient database of manually created clinical plans; those database plans provided g ... Full text Link to item Cite

Pilot Study Evaluating a Rat Model of Radiation-induced Erectile Dysfunction Using an Image-guided Microirradiator.

Journal Article Urology · May 2015 OBJECTIVE: To establish a feasible rat model of radiation-induced erectile dysfunction after targeted prostate irradiation using an image-guided irradiation unit specially designed for small-animal radiation research. METHODS: The X-RAD 225Cx research plat ... Full text Link to item Cite

Hyperthermia

Chapter · January 1, 2015 Full text Cite

Atm deletion with dual recombinase technology preferentially radiosensitizes tumor endothelium.

Journal Article J Clin Invest · August 2014 Cells isolated from patients with ataxia telangiectasia are exquisitely sensitive to ionizing radiation. Kinase inhibitors of ATM, the gene mutated in ataxia telangiectasia, can sensitize tumor cells to radiation therapy, but concern that inhibiting ATM in ... Full text Link to item Cite

Thermal dosimetry characteristics of deep regional heating of non-muscle invasive bladder cancer.

Journal Article Int J Hyperthermia · May 2014 PURPOSE: The aim of this paper is to report thermal dosimetry characteristics of external deep regional pelvic hyperthermia combined with intravesical mitomycin C (MMC) for treating bladder cancer following transurethral resection of bladder tumour, and to ... Full text Link to item Cite

The doubly labeled water method produces highly reproducible longitudinal results in nutrition studies.

Journal Article J Nutr · May 2014 The doubly labeled water (DLW) method is considered the reference method for the measurement of energy expenditure under free-living conditions. However, the reproducibility of the DLW method in longitudinal studies is not well documented. This study was d ... Full text Link to item Cite

Assessing cardiac injury in mice with dual energy-microCT, 4D-microCT, and microSPECT imaging after partial heart irradiation.

Journal Article Int J Radiat Oncol Biol Phys · March 1, 2014 PURPOSE: To develop a mouse model of cardiac injury after partial heart irradiation (PHI) and to test whether dual energy (DE)-microCT and 4-dimensional (4D)-microCT can be used to assess cardiac injury after PHI to complement myocardial perfusion imaging ... Full text Open Access Link to item Cite

Energy requirements in nonobese men and women: results from CALERIE.

Journal Article Am J Clin Nutr · January 2014 BACKGROUND: The energy intake necessary to maintain weight and body composition is called the energy requirement for weight maintenance and can be determined by using the doubly labeled water (DLW) method. OBJECTIVE: The objective was to determine the ener ... Full text Link to item Cite

Investigating end-to-end accuracy of image guided radiation treatment delivery using a micro-irradiator.

Journal Article Phys Med Biol · November 7, 2013 There is significant interest in delivering precisely targeted small-volume radiation treatments, in the pre-clinical setting, to study dose-volume relationships with tumour control and normal tissue damage. For these studies it is vital that image guidanc ... Full text Link to item Cite

PET with 62Cu-ATSM and 62Cu-PTSM is a useful imaging tool for hypoxia and perfusion in pulmonary lesions.

Journal Article AJR Am J Roentgenol · November 2013 OBJECTIVE: Hypoxia is a characteristic of many tumors and portends a worse prognosis in lung, cervical, prostate, and rectal cancers. Unlike the others, lung cancers present a unique challenge in measuring hypoxia, with invasive biopsies and higher rates o ... Full text Link to item Cite

On the need for comprehensive validation of deformable image registration, investigated with a novel 3-dimensional deformable dosimeter.

Journal Article Int J Radiat Oncol Biol Phys · October 1, 2013 PURPOSE: To introduce and evaluate a novel deformable 3-dimensional (3D) dosimetry system (Presage-Def/Optical-CT) and its application toward investigating the accuracy of dose deformation in a commercial deformable image registration (DIR) package. METHOD ... Full text Link to item Cite

A knowledge-based approach to improving and homogenizing intensity modulated radiation therapy planning quality among treatment centers: an example application to prostate cancer planning.

Journal Article Int J Radiat Oncol Biol Phys · September 1, 2013 PURPOSE: Intensity modulated radiation therapy (IMRT) treatment planning can have wide variation among different treatment centers. We propose a system to leverage the IMRT planning experience of larger institutions to automatically create high-quality pla ... Full text Link to item Cite

Positron emission tomography in radiation treatment planning: the potential of metabolic imaging.

Journal Article Radiol Clin North Am · September 2013 Treatment planning and delivery of radiation therapy has benefited from new technology and techniques. Given the convergence of the improved ability to image active tumor and the delivery of radiation to very specific targets, the implications for a tighte ... Full text Link to item Cite

Using FDG-PET to measure early treatment response in head and neck squamous cell carcinoma: quantifying intrinsic variability in order to understand treatment-induced change.

Journal Article AJNR Am J Neuroradiol · July 2013 BACKGROUND AND PURPOSE: Quantification of both baseline variability and intratreatment change is necessary to optimally incorporate functional imaging into adaptive therapy strategies for HNSCC. Our aim was to define the baseline variability of SUV on FDG- ... Full text Link to item Cite

Influence of filter choice on 18F-FDG PET segmentation accuracy determined using generalized estimating equations.

Journal Article Phys Med Biol · June 7, 2013 This study aims to quantify how filter choice affects several fluoro-deoxy-glucose (FDG)-positron emission tomography (PET) segmentation methods and present the use of model fitting via generalized estimating equations (GEEs) to appropriately account for t ... Full text Link to item Cite

TH-C-WAB-08: Modeling of the Dice Coefficient for PET Segmentation Studies.

Journal Article Med Phys · June 2013 PURPOSE: The Dice coefficient (DC) is a common accuracy metric in PET segmentation studies that is a measure of overlap between the segmented volume and ground truth. This work presents a methodology to model DC as a function of object shapes, sizes, contr ... Full text Link to item Cite

SU-C-105-03: Progress Toward the Development of a Deformable Anthropomorphic 3D Dosimetric Phantom.

Journal Article Med Phys · June 2013 PURPOSE: Previous work has demonstrated that Presage-Def, a deformable, polyurethane-based radiochromic 3D dosimeter, has strong potential for validating deformable image registration algorithms by tracking optically measured radiation patterns from the de ... Full text Link to item Cite

Analysis of single nucleotide polymorphisms and radiation sensitivity of the lung assessed with an objective radiologic endpoin.

Journal Article Clin Lung Cancer · May 2013 BACKGROUND: The primary objective of this study was to evaluate the association between radiation sensitivity of the lungs and candidate single nucleotide polymorphisms (SNP) in genes implicated in radiation-induced toxicity. METHODS: Patients with lung ca ... Full text Link to item Cite

Combining multiple FDG-PET radiotherapy target segmentation methods to reduce the effect of variable performance of individual segmentation methods.

Journal Article Med Phys · April 2013 PURPOSE: Many approaches have been proposed to segment high uptake objects in 18F-fluoro-deoxy-glucose positron emission tomography images but none provides consistent performance across the large variety of imaging situations. This study investigates the ... Full text Link to item Cite

SU‐E‐J‐200: Impact of FDG‐PET/CT Reconstruction Parameters On PET Variability and Treatment Response Assessment

Conference Medical Physics · January 1, 2013 Purpose: To examine the effect of PET image reconstruction parameters on baseline and early‐treatment FDG‐PET/CT quantitative imaging. Early‐treatment changes in tumor metabolism in primary tumor and nodes can potentially determine if the patient is respon ... Full text Cite

Preliminary investigation and application of a novel deformable PRESAGE® dosimeter.

Conference J Phys Conf Ser · 2013 Deformable 3D dosimeters have potential applications in validating deformable dose mapping algorithms. This study evaluates a novel deformable PRESAGE® dosimeter and its application toward validating the deformable algorithm employed by VelocityAI. The def ... Full text Link to item Cite

How accurate is image guided radiation therapy (IGRT) delivered with a micro-irradiator?

Conference J Phys Conf Ser · 2013 There is significant interest in delivering precisely targeted small-volume radiation treatments, in the pre-clinical setting, to study dose-volume relationships with tumor control and normal tissue damage. In this work we investigate the IGRT targeting ac ... Full text Link to item Cite

Assessing the impact of radiation-induced changes in soft tissue density ∕ thickness on the study of radiation-induced perfusion changes in the lung and heart.

Journal Article Med Phys · December 2012 PURPOSE: Abnormalities in single photon emission computed tomography (SPECT) perfusion within the lung and heart are often detected following radiation for tumors in∕around the thorax (e.g., lung cancer or left-sided breast cancer). The presence of SPECT p ... Full text Link to item Cite

Overcoming limitations in nanoparticle drug delivery: triggered, intravascular release to improve drug penetration into tumors.

Journal Article Cancer Res · November 1, 2012 Traditionally, the goal of nanoparticle-based chemotherapy has been to decrease normal tissue toxicity by improving drug specificity to tumors. The enhanced permeability and retention effect can permit passive accumulation into tumor interstitium. However, ... Full text Link to item Cite

p53 functions in endothelial cells to prevent radiation-induced myocardial injury in mice.

Journal Article Sci Signal · July 24, 2012 Radiation therapy, which is used for the treatment of some cancers, can cause delayed heart damage. In the heart, p53 influences myocardial injury that occurs after multiple types of stress. Here, we demonstrated that p53 functioned in endothelial cells to ... Full text Link to item Cite

WE-E-BRB-04: Quantitative Dose Tracking Enabled Through a Novel Deformable 3D Dosimeter.

Journal Article Med Phys · June 2012 PURPOSE: To evaluate and investigate the feasibility of a new method for validating dose tracking algorithms in deforming tissues using a novel deformable 3D dosimeter. METHODS: A novel deformable 3D Presage dosimeter is reported consisting of a stretchy p ... Full text Link to item Cite

SU-E-T-275: Dose Verification in a Small Animal Image-Guided Radiation Therapy X-Ray Machine: A Dose Comparison between TG-61 Based Look-Up Table and MOSFET Method for Various Collimator Sizes.

Journal Article Med Phys · June 2012 PURPOSE: To verify the accuracy of TG-61 based dosimetry with MOSFET technology using a tissue-equivalent mouse phantom. METHODS: Accuracy of mouse dose between a TG-61 based look-up table was verified with MOSFET technology. The look-up table followed a T ... Full text Link to item Cite

SU-E-T-559: Evaluation of Flatening Filter Free (FFF) Beams in Radiotherapy of Head and Neck Cancer.

Journal Article Med Phys · June 2012 PURPOSE: To investigate th applicability of the flattening filter free (FFF) to fractionated radiotherapy of head and neck cancer. METHODS: Twelve patients previously treated with IMRT were selected. A SIB protocol was chosen so that 66/54 Gy were prescrib ... Full text Link to item Cite

WE-G-BRCD-06: Knowledge-Based Intensity Modulated Radiotherapy (IMRT) Treatment Planning for Prostate Cancer.

Conference Med Phys · June 2012 PURPOSE: To verify that a knowledge-based approach to intensity modulated radiotherapy (IMRT) treatment planning can create clinically acceptable plans of higher or comparable dosimetric quality than prior clinically approved plans. METHODS: Each case in a ... Full text Link to item Cite

SU-E-T-572: A Plan Quality Metric for Evaluating Knowledge-Based Treatment Plans.

Conference Med Phys · June 2012 PURPOSE: In prostate IMRT treatment planning, the variation in patient anatomy makes it difficult to estimate a priori the potentially achievable extent of dose reduction possible to the rectum and bladder. We developed a mutual information-based framework ... Full text Link to item Cite

Stereotactic radiotherapy for malignancies involving the trigeminal and facial nerves.

Journal Article Technol Cancer Res Treat · June 2012 Involvement of a cranial nerve caries a poor prognosis for many malignancies. Recurrent or residual disease in the trigeminal or facial nerve after primary therapy poses a challenge due to the location of the nerve in the skull base, the proximity to the b ... Full text Link to item Cite

A heterogeneous human tissue mimicking phantom for RF heating and MRI thermal monitoring verification.

Journal Article Phys Med Biol · April 7, 2012 This paper describes a heterogeneous phantom that mimics a human thigh with a deep-seated tumor, for the purpose of studying the performance of radiofrequency (RF) heating equipment and non-invasive temperature monitoring with magnetic resonance imaging (M ... Full text Link to item Cite

Volumetric-modulated arc therapy: effective and efficient end-to-end patient-specific quality assurance.

Journal Article Int J Radiat Oncol Biol Phys · April 1, 2012 PURPOSE: To explore an effective and efficient end-to-end patient-specific quality-assurance (QA) protocol for volumetric modulated arc radiotherapy (VMAT) and to evaluate the suitability of a stationary radiotherapy QA device (two-dimensional [2D] ion cha ... Full text Link to item Cite

Utility of treatment planning for thermochemotherapy treatment of nonmuscle invasive bladder carcinoma.

Journal Article Med Phys · March 2012 PURPOSE: A recently completed Phase I clinical trial combined concurrent Mitomycin-C chemotherapy with deep regional heating using BSD-2000 Sigma-Ellipse applicator (BSD Corporation, Salt Lake City, UT, U.S.A.) for the treatment of nonmuscle invasive bladd ... Full text Link to item Cite

Approaches for quantifying energy intake and %calorie restriction during calorie restriction interventions in humans: the multicenter CALERIE study.

Journal Article Am J Physiol Endocrinol Metab · February 15, 2012 Calorie restriction (CR) is a component of most weight loss interventions and a potential strategy to slow aging. Accurate determination of energy intake and %CR is critical when interpreting the results of CR interventions; this is most accurately achieve ... Full text Link to item Cite

A polymorphism within the promoter of the TGFβ1 gene is associated with radiation sensitivity using an objective radiologic endpoint.

Journal Article Int J Radiat Oncol Biol Phys · February 1, 2012 PURPOSE: To evaluate whether single nucleotide polymorphisms (SNPs) in the transforming growth factor-β1 (TGFβ1) gene are associated with radiation sensitivity using an objective radiologic endpoint. METHODS AND MATERIALS: Preradiation therapy and serial p ... Full text Link to item Cite

Hyperthermia

Chapter · January 1, 2012 Full text Cite

MO‐G‐BRA‐01: Optimal Image Filtration Strategies for PET Segmentation

Conference Medical Physics · January 1, 2012 Purpose: Gaussian smoothing reduces noise in PET images but blurs edges impacting the achievable accuracy in radiotherapy target segmentation. Bilateral filters both provide smoothing while simultaneously preserving edges. We compared the accuracy of four ... Full text Cite

WE‐A‐217A‐02: The Impact of Fluorodeoxyglucose Positron Emission Tomography (FDG‐PET) Variability on the Assessment of Treatment Response in Head‐And‐Neck Cancer Patients Undergoing Chemoradiotherapy

Conference Medical Physics · January 1, 2012 Purpose: To compare intrinsic, temporal variability of tumor glucose metabolism versus early treatment‐induced change. This assessment is necessary to use changes in imaging parameters during therapy to properly segregate metabolic responders from non‐resp ... Full text Cite

TH‐A‐BRA‐11: Treatment‐Induced Dosimetric/Volume Changes During the Course of Radiotherapy for Lung Cancer

Conference Medical Physics · January 1, 2012 Purpose: To investigate the necessity for adaptive radiation therapy (RT) in lung cancer IMRT treatments by quantifying tumor changes during radiotherapy and the associated impact on target, lung and esophagus. Methods: As part of an IRB‐approved lung dose ... Full text Cite

Commissioning a small-field biological irradiator using point, 2D, and 3D dosimetry techniques.

Journal Article Med Phys · December 2011 PURPOSE: To commission a small-field biological irradiator, the XRad225Cx from Precision x-Ray, Inc., for research use. The system produces a 225 kVp x-ray beam and is equipped with collimating cones that produce both square and circular radiation fields r ... Full text Link to item Cite

The Use of Serial FDG-PET Scanning to Develop Metabolic Response Criteria to Chemoradiation in Head and Neck Cancer (HNC)

Journal Article International Journal of Radiation Oncology*Biology*Physics · October 2011 Full text Cite

Knowledge-based IMRT treatment planning for prostate cancer.

Journal Article Med Phys · May 2011 PURPOSE: To demonstrate the feasibility of using a knowledge base of prior treatment plans to generate new prostate intensity modulated radiation therapy (IMRT) plans. Each new case would be matched against others in the knowledge base. Once the best match ... Full text Link to item Cite

Functional and molecular image guidance in radiotherapy treatment planning optimization.

Journal Article Semin Radiat Oncol · April 2011 Functional and molecular imaging techniques are increasingly being developed and used to quantitatively map the spatial distribution of parameters, such as metabolism, proliferation, hypoxia, perfusion, and ventilation, onto anatomically imaged normal orga ... Full text Link to item Cite

Effect of calorie restriction on the free-living physical activity levels of nonobese humans: results of three randomized trials.

Journal Article J Appl Physiol (1985) · April 2011 The objective of this study was to evaluate the influence of calorie restriction (CR) on free-living physical activity levels among humans. Data were from three CALERIE phase I site-specific protocols. Participants were nonobese (body mass index = 23.5-29. ... Full text Link to item Cite

MO‐G‐BRB‐02: Commissioning a Small Animal Irradiator Using 2D and 3D Dosimetry Techniques

Conference Medical Physics · January 1, 2011 Purpose: To commission and characterize a novel small animal irradiator, the XRad225cx from Precision X‐Ray Inc. This system is capable of delivering both square and circular fields ranging in size from 1mm to 40mm. The combination of very small field size ... Full text Cite

SU‐E‐T‐851: An Inter‐Institutional Comparison of Knowledge‐Based IMRT Treatment Planning for Prostate Cancer

Conference Medical Physics · January 1, 2011 Purpose: To evaluate the feasibility of using a site‐specific database of prior plans to generate new prostate IMRT plans for cases drawn from an outside institution. Methods: The assembled database consists of 250 retrospective prostate IMRT treatment pla ... Full text Cite

TU‐C‐211‐12: Performance of a Novel Region Growing Segmentation Method for Nuclear Medicine

Conference Medical Physics · January 1, 2011 Purpose: To investigate the performance improvement of a novel region growing (SRG) and “segmentation‐by‐consensus” (SBC) technique for delineation of lesions in FDG‐PET. Further, the improvement in lesion segmentation using time‐of‐flight (TOF) PET was in ... Full text Cite

TU‐G‐214‐03: Functional Imaging for Radiotherapy Guidance and Treatment Monitoring

Conference Medical Physics · January 1, 2011 Functional imaging in radiotherapy has great promise to guide radiation delivery as well as to monitor response to treatment. Normal tissues as well as tumor tissues may be imaged with functional imaging. This talk will discuss positron emission tomography ... Full text Cite

WE‐G‐BRA‐01: A Framework to Determine Risk of Pneumonitis Following Radiotherapy for Lung Cancer

Conference Medical Physics · January 1, 2011 Purpose: To assess external validity of a framework, which was previously developed to predict the incidence of radiation‐induced pneumontis in patients following radiotherapy for lung cancer, by testing it on an alternate dataset (other than the one used ... Full text Cite

Hyperthermia

Chapter · January 1, 2011 Full text Cite

Improved hyperthermia treatment control using SAR/temperature simulation and PRFS magnetic resonance thermal imaging.

Journal Article Int J Hyperthermia · 2011 PURPOSE: This article explores the feasibility of using coupled electromagnetic and thermodynamic simulations to improve planning and control of hyperthermia treatments for cancer. The study investigates the usefulness of preplanning to improve heat locali ... Full text Link to item Cite

Biologically effective dose (BED) correlation with biochemical control after low-dose rate prostate brachytherapy for clinically low-risk prostate cancer.

Journal Article Int J Radiat Oncol Biol Phys · May 1, 2010 PURPOSE: To assess the correlation of postimplant dosimetric quantifiers with biochemical control of prostate cancer after low-dose rate brachytherapy. METHODS AND MATERIALS: The biologically effective dose (BED), dose in Gray (Gy) to 90% of prostate (D(90 ... Full text Link to item Cite

Mathematical formulation and analysis of the nonlinear system reconstruction of the online image-guided adaptive control of hyperthermia.

Journal Article Med Phys · March 2010 PURPOSE: A nonlinear system reconstruction can theoretically provide timely system reconstruction when designing a real-time image-guided adaptive control for multisource heating for hyperthermia. This clinical need motivates an analysis of the essential m ... Full text Link to item Cite

Effective learning strategies for real-time image-guided adaptive control of multiple-source hyperthermia applicators.

Journal Article Med Phys · March 2010 PURPOSE: This paper investigates overall theoretical requirements for reducing the times required for the iterative learning of a real-time image-guided adaptive control routine for multiple-source heat applicators, as used in hyperthermia and thermal abla ... Full text Link to item Cite

Radiation dose-volume effects in the stomach and small bowel.

Journal Article Int J Radiat Oncol Biol Phys · March 1, 2010 Published data suggest that the risk of moderately severe (>or=Grade 3) radiation-induced acute small-bowel toxicity can be predicted with a threshold model whereby for a given dose level, D, if the volume receiving that dose or greater (VD) exceeds a thre ... Full text Link to item Cite

Radiation-associated liver injury.

Journal Article Int J Radiat Oncol Biol Phys · March 1, 2010 The liver is a critically important organ that has numerous functions including the production of bile, metabolism of ingested nutrients, elimination of many waste products, glycogen storage, and plasma protein synthesis. The liver is often incidentally ir ... Full text Link to item Cite

Radiation-associated kidney injury.

Journal Article Int J Radiat Oncol Biol Phys · March 1, 2010 The kidneys are the dose-limiting organs for radiotherapy to upper abdominal cancers and during total body irradiation. The incidence of radiotherapy-associated kidney injury is likely underreported owing to its long latency and because the toxicity is oft ... Full text Link to item Cite

The utility of non-axial treatment beam orientations for lower lobe lung cancers.

Journal Article J Appl Clin Med Phys · January 28, 2010 Traditional treatment beams for non-small-cell lung cancer are limited to the axial plane. For many tumor geometries, non-axial orientations appear to reduce the dose to normal tissues (e.g. heart, liver). We hypothesize that non-axial beams provide a sign ... Full text Link to item Cite

A methodology for selecting the beam arrangement to reduce the intensity-modulated radiation therapy (IMRT) dose to the SPECT-defined functioning lung.

Journal Article Phys Med Biol · January 21, 2010 Macroaggregated albumin single-photon emission computed tomography (MAA-SPECT) provides a map of the spatial distribution of lung perfusion. Our previous work developed a methodology to use SPECT guidance to reduce the dose to the functional lung in IMRT p ... Full text Link to item Cite

Similarities between static and rotational intensity-modulated plans.

Journal Article Phys Med Biol · January 7, 2010 The aim of this study was to explore similarities between intensity-modulated radiotherapy (IMRT) and intensity-modulated arc therapy (IMAT) techniques in the context of the number of multi-leaf collimator (MLC) segments required to achieve plan objectives ... Full text Link to item Cite

SU‐GG‐T‐136: Treatment Plans Comparison with Static‐Gantry IMRT and RapidArcTM for Head‐And‐Neck Cancers Involving Cervical Lymph Nodes

Conference Medical Physics · January 1, 2010 Purpose: To compare the dosimetric results and treatment efficiency of intensity modulated arc therapy using RapidArc™ to static‐gantry IMRT plans for conventional fractionation treatment of head‐and‐neck cancer. Materials and Methods: This study evaluated ... Full text Cite

SU‐GG‐T‐131: A Linear Metric of Knowledge‐Based IMRT Treatment Plan Quality for the Prostate

Conference Medical Physics · January 1, 2010 Purpose: In prostate IMRT treatment planning, the variation in patient anatomy makes it difficult to a priori estimate the maximum extent of dose reduction possible to rectum and bladder. Such an estimation would greatly aid treatment planning by letting c ... Full text Cite

SU‐GG‐T‐225: Gantry‐Angle Dependence of a 2D Ion Chamber Array for IMAT QA

Conference Medical Physics · January 1, 2010 Purpose: Gantry‐angle dependence of dose measurement for intensity‐modulated arc therapy (IMAT) quality assurance (QA) using a two‐dimensional ion chamber array may be significant. A new device, the gantry angle sensor, has been provided to compensate for ... Full text Cite

SU‐GG‐T‐491: Identifying Patients Who Will Potentially Benefit from Functional‐Guided Lung Avoidance in Thoracic Radiotherapy

Conference Medical Physics · January 1, 2010 Purpose: Single photon emission computed tomography (SPECT) may be used to guide thoracic radiation therapy planning by reducing the dose to highly‐perfused (i.e.functional) regions of lung. We herein investigate whether it is possible to a priori predict ... Full text Cite

SU‐GG‐T‐137: Similarities between Static and Rotational Intensity Modulated Plans

Conference Medical Physics · January 1, 2010 Purpose: To explore similarities between intensity modulated radiotherapy (IMRT) and intensity modulated arc therapy (IMAT) techniques in the context of the number of multi‐leaf collimator (MLC) segments required to achieve plan objectives, the major facto ... Full text Cite

MO‐EE‐A2‐04: A Framework to Determine the Risk of Developing Pneumonitis in Lung Cancer Patients Undergoing Radiotherapy

Conference Medical Physics · January 1, 2010 Purpose: To determine which dose and non‐dose features of patients undergoing thoracic radiotherapy best predict the incidence of possible lung pneumonitis and to estimate the corresponding risk of developing pneumonitis. Method and Materials: The study em ... Full text Cite

SU‐GG‐T‐134: Knowledge‐Based IMRT Treatment Planning for Prostate Cancer

Conference Medical Physics · January 1, 2010 Purpose: To investigate the potential of utilizing a knowledge‐base of clinically approved plans to develop semi‐automated IMRT treatment plans for prostate cancer. Method and Materials: We assembled a database of 100 prostate IMRT treatment plans and deve ... Full text Cite

Patient specific quality assurance: Transition from IMRT to IMAT

Journal Article Journal of Physics: Conference Series · January 1, 2010 The purpose of this study was to test a patient-specific quality assurance (QA) protocol for intensity-modulated arc radiotherapy (IMAT), and to evaluate the use of an intensity-modulated stationary radiotherapy QA device (2D ion chamber array). Thirty-nin ... Full text Cite

The utility of non-axial treatment beam orientations for lower lobe lung cancers

Journal Article Journal of Applied Clinical Medical Physics · January 1, 2010 Traditional treatment beams for non-small-cell lung cancer are limited to the axial plane. For many tumor geometries, non-axial orientations appear to reduce the dose to normal tissues (e.g. heart, liver). We hypothesize that non-axial beams provide a sign ... Full text Cite

Accuracy of real time noninvasive temperature measurements using magnetic resonance thermal imaging in patients treated for high grade extremity soft tissue sarcomas.

Journal Article Med Phys · November 2009 PURPOSE: To establish accuracy of real time noninvasive temperature measurements using magnetic resonance thermal imaging in patients treated for high grade extremity soft tissue sarcomas. METHODS: Protocol patients with advanced extremity sarcomas were tr ... Full text Link to item Cite

A role for biological optimization within the current treatment planning paradigm.

Journal Article Med Phys · October 2009 PURPOSE: Biological optimization using complication probability models in intensity modulated radiotherapy (IMRT) planning has tremendous potential for reducing radiation-induced toxicity. Nevertheless, biological optimization is almost never clinically ut ... Full text Link to item Cite

Tradeoffs of integrating real-time tracking into IGRT for prostate cancer treatment.

Journal Article Phys Med Biol · September 7, 2009 This study investigated the integration of the Calypso real-time tracking system, based on implanted ferromagnetic transponders and a detector array, into the current process for image-guided radiation treatment (IGRT) of prostate cancer at our institution ... Full text Link to item Cite

A method to dynamically balance intensity modulated radiotherapy dose between organs-at-risk.

Journal Article Med Phys · May 2009 The IMRT treatment planning process typically follows a path that is based on the manner in which the planner interactively adjusts the target and organ-at-risk (OAR) constraints and priorities. The time-intensive nature of this process restricts the plann ... Full text Link to item Cite

The performance of a reduced-order adaptive controller when used in multi-antenna hyperthermia treatments with nonlinear temperature-dependent perfusion.

Journal Article Phys Med Biol · April 7, 2009 In large multi-antenna systems, adaptive controllers can aid in steering the heat focus toward the tumor. However, the large number of sources can greatly increase the steering time. Additionally, controller performance can be degraded due to changes in ti ... Full text Link to item Cite

Real-time MRI-guided hyperthermia treatment using a fast adaptive algorithm.

Journal Article Phys Med Biol · April 7, 2009 Magnetic resonance (MR) imaging is promising for monitoring and guiding hyperthermia treatments. The goal of this work is to investigate the stability of an algorithm for online MR thermal image guided steering and focusing of heat into the target volume. ... Full text Link to item Cite

Tracking brachytherapy sources using emission imaging with one flat panel detector.

Journal Article Med Phys · April 2009 This work proposes to use the radiation from brachytherapy sources to track their dwell positions in three-dimensional (3D) space. The prototype device uses a single flat panel detector and a BB tray. The BBs are arranged in a defined pattern. The shadow o ... Full text Link to item Cite

Integral dose conservation in radiotherapy.

Journal Article Med Phys · March 2009 Treatment planners frequently modify beam arrangements and use IMRT to improve target dose coverage while satisfying dose constraints on normal tissues. The authors herein analyze the limitations of these strategies and quantitatively assess the extent to ... Full text Link to item Cite

Clinical Utility of Magnetic Resonance Thermal Imaging (MRTI) For Realtime Guidance of Deep Hyperthermia.

Journal Article Proc SPIE Int Soc Opt Eng · February 25, 2009 A critical need has emerged for volumetric thermometry to visualize 3D temperature distributions in real time during deep hyperthermia treatments used as an adjuvant to radiation or chemotherapy for cancer. For the current effort, magnetic resonance therma ... Full text Link to item Cite

Control time reduction using virtual source projection for treating a leg sarcoma with nonlinear perfusion.

Journal Article Proc SPIE Int Soc Opt Eng · February 12, 2009 PURPOSE: Blood perfusion is a well-known factor that complicates accurate control of heating during hyperthermia treatments of cancer. Since blood perfusion varies as a function of time, temperature and location, determination of appropriate power depositi ... Full text Link to item Cite

Quantifying the dosimetric trade-offs when using intensity-modulated radiotherapy to treat concave targets containing normal tissues.

Journal Article Int J Radiat Oncol Biol Phys · February 1, 2009 PURPOSE: To quantitatively assess the relationship between intensity-modulated radiotherapy (IMRT)-driven sparing of dose to normal tissues located "within" concave targets with heterogeneity in dose delivered to the target and redistribution of dose to no ... Full text Link to item Cite

SU‐FF‐T‐498: Improving Normal Tissue Complication Probability Fits Using Non‐Binary Outcomes

Conference Medical Physics · January 1, 2009 Purpose: Binary outcomes (toxicity=1, no‐toxicity=0) are frequently used as inputs to fit parametric models. However, in reality, outcomes span the range in‐between these extremes; binary values are used for lack of more precise quantification. We propose ... Full text Cite

SU‐FF‐T‐130: Radiotherapy Treatment Plans with RapidArc for Head‐And‐Neck Cancer

Conference Medical Physics · January 1, 2009 Purpose: The purpose of this study is to compare RapidArc plans and conventional IMRT plans for head‐and‐neck cancer treatment involving bilateral nodes. Methods and Materials: This study included 10 locally advanced head‐and‐neck cancer patients. The plan ... Full text Cite

SU‐FF‐T‐314: Patient‐Specific Quality Assurance Techniques for RapidArc Radiotherapy

Conference Medical Physics · January 1, 2009 Purpose: To develop a patient‐specific quality assurance protocol for RapidArc™ radiotherapy. Method and Materials: Following the commissioning of RapidArc™ treatment delivery, we tested several methods of patient‐specific quality assurance (QA). Ion chamb ... Full text Cite

SU‐FF‐J‐56: Integrating Real‐Time Tracking Into Image Guided Radiation Therapy for Prostate Cancer Treatment

Conference Medical Physics · January 1, 2009 Purpose: To investigate how a real‐time tracking technique, based on implanted transponders, could be effectively integrated into the current process for image‐guided radiation treatment of prostate cancer. Method and Materials: Current prostate IGRT proce ... Full text Cite

SU‐FF‐T‐158: A Method to Overlay Biological Optimization On Traditional Dose‐Volume Constrained Intensity Modulated Radiotherapy (IMRT) Optimization

Conference Medical Physics · January 1, 2009 Purpose: Biological optimization for IMRT planning is typically not clinically utilized, perhaps due to uncertainties associated with normal tissue complication models. Clinically, IMRT planning still relies heavily on dose‐volume constraints. We propose a ... Full text Cite

Dosimetric and radiobiologic comparison of 3D conformal versus intensity modulated planning techniques for prostate bed radiotherapy.

Journal Article Med Dosim · 2009 Adjuvant radiotherapy for locally advanced prostate cancer improves biochemical and clinical disease-free survival. While comparisons in intact prostate cancer show a benefit for intensity modulated radiation therapy (IMRT) over 3D conformal planning, this ... Full text Link to item Cite

Clinical evaluation of positioning verification using digital tomosynthesis and bony anatomy and soft tissues for prostate image-guided radiotherapy.

Journal Article Int J Radiat Oncol Biol Phys · January 1, 2009 PURPOSE: To evaluate on-board digital tomosynthesis (DTS) for patient positioning vs. two-dimensional (2D) radiography and three-dimensional cone beam (CBCT). METHODS AND MATERIALS: A total of 92 image sessions from 9 prostate cancer patients were analyzed ... Full text Link to item Cite

Decision fusion of machine learning models to predict radiotherapyinduced lung pneumonitis

Journal Article Proceedings - 7th International Conference on Machine Learning and Applications, ICMLA 2008 · December 1, 2008 Combining different machine learning models (decision fusion) has been shown to be an effective method for estimating the underlying physical mechanism by allowing the models to reinforce each other when consensus exists, or, conversely, negate each other ... Full text Cite

A genetic algorithm for variable selection in logistic regression analysis of radiotherapy treatment outcomes.

Journal Article Med Phys · December 2008 A given outcome of radiotherapy treatment can be modeled by analyzing its correlation with a combination of dosimetric, physiological, biological, and clinical factors, through a logistic regression fit of a large patient population. The quality of the fit ... Full text Link to item Cite

Combining multiple models to generate consensus: application to radiation-induced pneumonitis prediction.

Journal Article Med Phys · November 2008 The fusion of predictions from disparate models has been used in several fields to obtain a more realistic and robust estimate of the "ground truth" by allowing the models to reinforce each other when consensus exists, or, conversely, negate each other whe ... Full text Link to item Cite

Fast temperature optimization of multi-source hyperthermia applicators with reduced-order modeling of 'virtual sources'.

Journal Article Phys Med Biol · March 21, 2008 The goal of this work is to build the foundation for facilitating real-time magnetic resonance image guided patient treatment for heating systems with a large number of physical sources (e.g. antennas). Achieving this goal requires knowledge of how the tem ... Full text Link to item Cite

Using patient data similarities to predict radiation pneumonitis via a self-organizing map.

Journal Article Phys Med Biol · January 7, 2008 This work investigates the use of the self-organizing map (SOM) technique for predicting lung radiation pneumonitis (RP) risk. SOM is an effective method for projecting and visualizing high-dimensional data in a low-dimensional space (map). By projecting p ... Full text Link to item Cite

SU‐GG‐T‐406: Improving Lung Radiation‐Pneumonitis Prediction by Combining Different Models

Conference Medical Physics · January 1, 2008 Purpose: Combining the results of methodologically different models (decision fusion) has been shown to yield a fused result that more truthfully represents the underlying phenomenon, compared to the individual models. In this work, we study the effect of ... Full text Cite

WE‐C‐AUD B‐05: Predicting Radiation‐Induced Cardiac Perfusion Defects Using a Fusion Model

Conference Medical Physics · January 1, 2008 Purpose: To predict radiation‐induced cardiac perfusion defects using a fusion model that combines the results of four separate models: feed‐forward neural networks (NNET), self‐organizing maps (SOM), support vector machines (SVM), and multivariate adaptiv ... Full text Cite

SU‐GG‐T‐367: Fast Hyperthermia Temperature Optimization for Pelvic Carcinoma Patient Treated in Sigma‐Eye Applicator

Conference Medical Physics · January 1, 2008 Purpose: Though hyperthermia shows promising features being used with radiation and chemotherapy, it requires accurate spatial power focusing, which leads a workload proportional to square of number of antennas in an applicator. This motivates this investi ... Full text Cite

MO‐D‐351‐07: A System to Dynamically Balance Dose Sparing Between Critical Structures in Intensity Modulated Radiation Therapy (IMRT)

Conference Medical Physics · January 1, 2008 Purpose: The IMRT treatment planning optimization process typically follows one, somewhat arbitrary, path, based on the manner in which the planner changes the optimization constraints/weights during planning. Thus, the planner usually never fully understa ... Full text Cite

SU‐GG‐J‐81: Efficacy of Patient Setup Correction Procedure in Prostate Radiotherapy

Conference Medical Physics · January 1, 2008 Purpose: Using an on‐board cone‐beam CT (CBCT) based statistical margin model to determine whether a prostate center‐of‐mass (COM) based translation correction procedure can significantly reduce the CTV‐to‐PTV margin required for prostate patients who were ... Full text Cite

TU‐D‐AUD B‐05: Quantifying the Dosimetric Trade‐Offs When Treating Targets with Concavities Using IMRT

Conference Medical Physics · January 1, 2008 Purpose: To quantitatively assess the relationship between intensity‐modulated radiotherapy (IMRT)‐driven sparing of dose to normal tissues located “within” concave targets with (1) heterogeneity in dose delivered to the target and (2) redistribution of do ... Full text Cite

SU‐GG‐T‐366: Hyperthermia Treatment for a Patient with Two Shank Sarcomas Treated by a Fast Pre‐Treatment Optimization Method

Conference Medical Physics · January 1, 2008 Purpose: Cancerous cells are infiltrative and can invade neighborhood and/or distant body. While hyperthermia shows promising synergistic effects being used with radiation and/or chemotherapy, current microwave/radiofrequency power focusing techniques only ... Full text Cite

SU‐GG‐J‐164: Real‐Time Magnetic Resonance Imaging (MRI) Guidance and Thermal Modeling to Focus Hyperthermia Delivery

Conference Medical Physics · January 1, 2008 Purpose: Hyperthermia is an effective adjuvant modality for treatment of locally advanced cancer. However, focusing heat in the tumor using an external microwave applicator can be difficult, due to electromagnetic wave reflections at tissue interfaces. We ... Full text Cite

Equivalent uniform dose, D(90), and V(100) correlation with biochemical control after low-dose-rate prostate brachytherapy for clinically low-risk prostate cancer.

Journal Article Brachytherapy · 2008 PURPOSE: To assess the correlation of postimplant dosimetric quantifiers with biochemical control of prostate cancer after low-dose-rate brachytherapy. MATERIALS AND METHODS: Generalized equivalent uniform dose (EUD), dose in Gy to 90% of the prostate glan ... Full text Link to item Cite

Response to comments by Dr. Luijik and Dr. Schippers

Journal Article Medical Physics · January 1, 2008 Full text Cite

Online feedback focusing algorithm for hyperthermia cancer treatment.

Journal Article Int J Hyperthermia · November 2007 PURPOSE: Magnetic resonance (MR) imaging is increasingly being utilized to visualize the 3D temperature distribution in patients during treatment with hyperthermia or thermal ablation therapy. The goal of this work is to lay the foundation for improving th ... Full text Link to item Cite

Investigation of the support vector machine algorithm to predict lung radiation-induced pneumonitis.

Journal Article Med Phys · October 2007 The purpose of this study is to build and test a support vector machine (SVM) model to predict for the occurrence of lung radiation-induced Grade 2+ pneumonitis. SVM is a sophisticated statistical technique capable of separating the two categories of patie ... Full text Link to item Cite

A neural network model to predict lung radiation-induced pneumonitis.

Journal Article Med Phys · September 2007 A feed-forward neural network was investigated to predict the occurrence of lung radiation-induced Grade 2+ pneumonitis. The database consisted of 235 patients with lung cancer treated using radiotherapy, of whom 34 were diagnosed with Grade 2+ pneumonitis ... Full text Link to item Cite

Predicting lung radiotherapy-induced pneumonitis using a model combining parametric Lyman probit with nonparametric decision trees.

Journal Article Int J Radiat Oncol Biol Phys · July 15, 2007 PURPOSE: To develop and test a model to predict for lung radiation-induced Grade 2+ pneumonitis. METHODS AND MATERIALS: The model was built from a database of 234 lung cancer patients treated with radiotherapy (RT), of whom 43 were diagnosed with pneumonit ... Full text Link to item Cite

Self-consistent tumor control probability and normal tissue complication probability models based on generalized EUDa).

Journal Article Med Phys · July 2007 Traditional methods to compute the tumor control probability (TCP) or normal tissue complication probability (NTCP) typically require a heterogeneous radiation dose distribution to be converted into a simple uniform dose distribution with an equivalent bio ... Full text Link to item Cite

Updated assessment of the six-minute walk test as predictor of acute radiation-induced pneumonitis.

Journal Article Int J Radiat Oncol Biol Phys · March 1, 2007 PURPOSE: To assess the utility of the 6-minute walk test (6MWT) as a predictor of symptomatic radiation-induced pneumonitis (RP). METHODS: As part of a prospective trial to study radiation-induced lung injury, 53 patients receiving thoracic radiotherapy (R ... Full text Link to item Cite

WE‐D‐M100J‐04: Prediction of Lung Radiation‐Induced Pneumonitis Using the Support Vector Machine Algorithm

Journal Article Medical Physics · January 1, 2007 Purpose: To build and test a Support Vector Machine (SVM) model to predict the occurrence of lung radiation‐induced Grade 2+ pneumonitis. SVM is a sophisticated statistical technique that is capable of using complex hypersurfaces to separate the cases with ... Full text Cite

TH‐D‐M100E‐07: Determining the Geometric and Dosimetric Accuracy of MRI Based IMRT Treatment Plan for Patients with Prostate, Brain, and Head and Neck Cancers

Journal Article Medical Physics · January 1, 2007 Purpose: To determine the geometric and dosimetric accuracy of MRI‐based IMRT treatment plan for patients with prostate, brain, and head and neck cancers. Methods and Material: CT simulation images were obtained for prostate, brain and head and neck cancer ... Full text Cite

SU‐FF‐J‐68: Dosimetric Comparison of Patient‐Specific Margins Vs. Uniform Margins for Prostate IMRT Treatments

Conference Medical Physics · January 1, 2007 Purpose: To evaluate the dosimetric improvement of IMRT treatment plans generated with patient‐specific margins compared to uniform margins for prostate cancer patients. Methods and Materials: For 13 prostate cancer patients who underwent IMRT treatment, d ... Full text Cite

SU‐FF‐T‐88: Augmenting Lyman NTCP by Adding the Influence of Non‐Dose Variables Via Decision Trees: Application to Lung Radiation‐Pneumonitis Prediction

Conference Medical Physics · January 1, 2007 Purpose: Develop a model that augments the dose‐based parametric Lyman NTCP formulation using non‐parametric decision trees that can additionally account for the influence of non‐dose variables. Apply and test the model to predict Grade 2+ lung radiotherap ... Full text Cite

TH‐E‐M100E‐03: Optimizing the Methodology for Incorporating SPECT‐Guidance to Reduce Intensity Modulated Radiation Therapy (IMRT) Dose to Functioning Lung

Conference Medical Physics · January 1, 2007 Purpose: Single photon emission computed tomography (SPECT) provides a spatial distribution map of lung perfusion. Previously, an algorithmic methodology was developed using IMRT and SPECT guidance to deliberately divert dose away from higher functioning ( ... Full text Cite

SU‐FF‐J‐81: Estimation of Dose Variations During Prostate Radiation Treatment Due to Elastic Deformations of Soft Tissues

Conference Medical Physics · January 1, 2007 Objective: The true dose distribution is subject to change due to organ shifts and also deformations. The goal of this work is to estimate the effect of the elastic organ deformations on the dose distribution for the average prostate IMRT treatment. Method ... Full text Cite

WE‐D‐M100J‐03: A Neural Network Model to Predict Lung Radiation‐Induced Pneumonitis

Conference Medical Physics · January 1, 2007 Purpose: To build and test a feed‐forward neural network model to predict the occurrence of lung radiation‐induced Grade 2+ pneumonitis. Method and Materials: The database comprised 235 patients with lung cancer treated using radiotherapy (34 diagnosed wit ... Full text Cite

TU‐EE‐A1‐04: Dimension Reduction Analysis of Dose Volume Histogram And Its Potential Application In Predicting Normal Tissue Complication Probability

Conference Medical Physics · January 1, 2007 Purpose: Radiation pneumonitis (RP) is a major concern for patients receiving radiotherapy for lung cancer. The present study assesses the possibility of using multiple dose‐volume‐histogram (DVH) based metrics to predict the likelihood of grade ⩾ 2 RP. MA ... Full text Cite

A methodology for using SPECT to reduce intensity-modulated radiation therapy (IMRT) dose to functioning lung.

Journal Article Int J Radiat Oncol Biol Phys · December 1, 2006 PURPOSE: Single photon emission computed tomography (SPECT) provides a map of the spatial distribution of lung perfusion. Thus, SPECT guidance can be used to divert dose away from higher-functioning lung, potentially reducing lung toxicity. We present a me ... Full text Link to item Cite

Physics and imaging for targeting of oligometastases.

Journal Article Semin Radiat Oncol · April 2006 Featured Publication Oligometastases refer to metastases that are limited in number and location and are amenable to regional treatment. The majority of these metastases appear in the brain, lung, liver, and bone. Although the focus of interest in the past within radiation onc ... Full text Link to item Cite

SU‐FF‐T‐208: Efficient Selection of Beam Number and Orientations for Intensity Modulated Radiotherapy (IMRT) by Emulating An Ideal Dose Distribution

Conference Medical Physics · January 1, 2006 Purpose: Since radiotherapy treatments only utilize a limited number of beams, it is important that these beams be carefully selected to extract maximum benefit. Here we propose a novel, fast, scheme that selects beam number and orientations for IMRT with ... Full text Cite

WE‐E‐ValA‐03: Dosimetric Evaluation of Prostate IMRT Treatments Positioned Based On Cone‐Beam CT

Conference Medical Physics · January 1, 2006 Purpose: To evaluate the dosimetric consequence of 3D positioning verification for prostate IMRT treatment using CBCT. Method and Materials: Patients in this study were repositioned using 2D orthogonal radiographic images, taken prior to treatment to match ... Full text Cite

SU‐FF‐J‐22: An Image Based Statistical Shape Model and Its Application in Radiotherapy Margin Design

Conference Medical Physics · January 1, 2006 Purpose: A novel imaging based model is proposed to describe the stochastic nature of the shape and location of a volume of interest (VOI). Based on the VOIs in sequential patient images, the model can predict the probability that a specific point will bel ... Full text Cite

SU‐FF‐J‐16: A Tool for Off‐Line Review of 3D Target Verification and Localization with Cone‐Beam Computed Tomography

Conference Medical Physics · January 1, 2006 Purpose: To implement a clinical tool for off‐line review of Cone‐Beam Computed Tomography (CBCT) based 3D target verification and localization. Methods and Materials: An in‐house 3D target localization and verification tool is being developed to allow phy ... Full text Cite

TH‐C‐224C‐09: Using SPECT‐Guidance to Reduce Intensity Modulated Radiation Therapy (IMRT) Dose to Functioning Lung

Conference Medical Physics · January 1, 2006 Purpose: Single photon emission computed tomography (SPECT) provides a map of the spatial distribution of lung perfusion. Thus, SPECT guidance can be used to deliberately divert dose away from higher functioning lung, thereby potentially reducing lung toxi ... Full text Cite

Improved magnetic resonance thermal imaging by combining proton resonance frequency shift (PRFS) and apparent diffusion coefficient (ADC) data.

Journal Article Int J Hyperthermia · November 2005 Featured Publication Effective thermal therapy for cancer is dependent on adequate tumor heating. Adequate heating, in turn, is dependent on reliable volumetric measurement of temperature to guide heating. Proton resonance frequency shift (PRFS) magnetic resonance imaging is f ... Full text Link to item Cite

WE‐D‐T‐6E‐02: A Clinical Planning Tool for Optimization of Intensity Modulated Radiotherapy Parameters

Journal Article Medical Physics · January 1, 2005 Purpose: To develop a clinical tool that incorporates novel strategies to optimize all involved parameters in IMRT treatment planning: (a) the number of beams, (b) beam orientations, and (c) fluence maps. Method and Materials: An IMRT planning tool was dev ... Full text Cite

Predicting radiotherapy-induced cardiac perfusion defects.

Journal Article Med Phys · January 2005 Featured Publication The purpose of this work is to compare the efficacy of mathematical models in predicting the occurrence of radiotherapy-induced left ventricular perfusion defects assessed using single-photon emission computed tomography (SPECT). The basis of this study is ... Full text Link to item Cite

SU‐FF‐J‐30: Quantification of Normal Organ Motion Due to the Respiratory and Cardiac Cycles

Conference Medical Physics · January 1, 2005 Purpose: To quantify the degree of normal organ motion due to the respiratory and cardiac cycles. Better definition of such motion may be useful in defining field margins and in assessing the utility of gating technologies. Method and Materials: Four healt ... Full text Cite

Relationship between the generalized equivalent uniform dose formulation and the Poisson statistics-based tumor control probability model.

Journal Article Med Phys · September 2004 Featured Publication The generalized equivalent uniform dose (GEUD) model uses a power-law formalism, where the outcome is related to the dose via a power law. We herein investigate the mathematical compatibility between this GEUD model and the Poisson statistics based tumor c ... Full text Link to item Cite

Penalized likelihood fluence optimization with evolutionary components for intensity modulated radiation therapy treatment planning.

Journal Article Med Phys · August 2004 Featured Publication A novel iterative penalized likelihood algorithm with evolutionary components for the optimization of beamlet fluences for intensity modulated radiation therapy (IMRT) is presented. This algorithm is designed to be flexible in terms of the objective functi ... Full text Link to item Cite

A preliminary study of the role of modulated electron beams in intensity modulated radiotherapy, using automated beam orientation and modality selection.

Journal Article Int J Radiat Oncol Biol Phys · June 1, 2004 Featured Publication PURPOSE: To develop an algorithm for optimal beam arrangement selection in intensity-modulated radiotherapy (IMRT) of mixed photon and electron beams. To apply this algorithm to study the utility of modulated electron beams in the context of IMRT planning. ... Full text Link to item Cite

Feasibility of optimizing the dose distribution in lung tumors using fluorine-18-fluorodeoxyglucose positron emission tomography and single photon emission computed tomography guided dose prescriptions.

Journal Article Med Phys · June 2004 Featured Publication The information provided by functional images may be used to guide radiotherapy planning by identifying regions that require higher radiation dose. In this work we investigate the dosimetric feasibility of delivering dose to lung tumors in proportion to th ... Full text Link to item Cite

Incorporation of functional imaging data in the evaluation of dose distributions using the generalized concept of equivalent uniform dose.

Journal Article Phys Med Biol · May 7, 2004 Featured Publication Advances in the fields of IMRT and functional imaging have greatly increased the prospect of escalating the dose to highly active or hypoxic tumour sub-volumes and steering the dose away from highly functional critical structure regions. However, current c ... Full text Link to item Cite

A dose-volume-based tool for evaluating and ranking IMRT treatment plans.

Journal Article Journal of applied clinical medical physics / American College of Medical Physics · January 1, 2004 External beam radiotherapy is commonly used for patients with cancer. While tumor shrinkage and palliation are frequently achieved, local control and cure remain elusive for many cancers. With regard to local control, the fundamental problem is that radiot ... Full text Cite

A dose-volume-based tool for evaluating and ranking IMRT treatment plans.

Journal Article J Appl Clin Med Phys · 2004 Featured Publication External beam radiotherapy is commonly used for patients with cancer. While tumor shrinkage and palliation are frequently achieved, local control and cure remain elusive for many cancers. With regard to local control, the fundamental problem is that radiot ... Full text Link to item Cite

Beam orientation selection for intensity-modulated radiation therapy based on target equivalent uniform dose maximization.

Journal Article Int J Radiat Oncol Biol Phys · January 1, 2003 Featured Publication PURPOSE: To develop an automated beam-orientation selection procedure for intensity-modulated radiotherapy (IMRT), and to determine if a small number of beams picked by this automated procedure can yield results comparable to a large number of manually pla ... Full text Link to item Cite

Optimization of a 90Sr/90Y radiation source train stepping for intravascular brachytherapy.

Journal Article Medical physics · December 2002 Featured Publication A steepest-descent gradient algorithm is developed to optimize the stepping of a 90Sr/90Y radiation source train (RST) for intravascular brachytherapy (IVB). The objective function is to deliver a uniform dose in a coronary target vessel and minimize the d ... Full text Cite

Fractal reconstruction of breast perfusion before and after hyperthermia treatments

Journal Article ASME International Mechanical Engineering Congress and Exposition, Proceedings · January 1, 2002 Thermal modeling for hyperthermia breast patients can provide relevant information to better understand the temperatures achieved during treatment. However, human breast is much perfiased, making knowledge of the perfusion crucial to the accuracy of the te ... Full text Cite

Fractal reconstruction of breast perfusion before and after hyperthermia treatments

Journal Article American Society of Mechanical Engineers, Bioengineering Division (Publication) BED · 2002 Cite

Radiation-induced pulmonary toxicity: a dose-volume histogram analysis in 201 patients with lung cancer.

Journal Article Int J Radiat Oncol Biol Phys · November 1, 2001 Featured Publication PURPOSE: To relate lung dose-volume histogram-based factors to symptomatic radiation pneumonitis (RP) in patients with lung cancer undergoing 3-dimensional (3D) radiotherapy planning. METHODS AND MATERIALS: Between 1991 and 1999, 318 patients with lung can ... Full text Link to item Cite

Discretizing large traceable vessels and using DE-MRI perfusion maps yields numerical temperature contours that match the MR noninvasive measurements.

Journal Article Med Phys · November 2001 Featured Publication The success of hyperthermia treatments is dependent on thermal dose distribution. However, the three-dimensional temperature distribution remains largely unknown. Without this knowledge, the relationship between thermal dose and outcome is noisy, and thera ... Full text Link to item Cite

Acute urinary toxicity following transperineal prostate brachytherapy using a modified Quimby loading method.

Journal Article Int J Radiat Oncol Biol Phys · July 15, 2001 Featured Publication PURPOSE: To examine the acute urinary toxicity following transperineal prostate implant using a modified Quimby loading method with regard to time course, severity, and factors that may be associated with a higher incidence of morbidity. METHODS AND MATERI ... Full text Link to item Cite

Three-dimensional tumor perfusion reconstruction using fractal interpolation functions.

Journal Article IEEE Trans Biomed Eng · April 2001 Featured Publication It has been shown that the perfusion of blood in tumor tissue can be approximated using the relative perfusion index determined from dynamic contrast-enhanced magnetic resonance imaging (DE-MRI) of the tumor blood pool. Also, it was concluded in a previous ... Full text Link to item Cite

A method of MRI-based thermal modelling for a RF phased array.

Journal Article Int J Hyperthermia · 2001 Featured Publication Magnetic Resonance Imaging (MRI) is an attractive method of temperature monitoring in vivo due to its non-invasive nature. The natural extension of this temperature monitoring is to implement temperature control. This work outlines a method of MRI-based th ... Full text Link to item Cite

3D numerical reconstruction of the hyperthermia induced temperature distribution in human sarcomas using DE-MRI measured tissue perfusion: validation against non-invasive MR temperature measurements.

Journal Article Int J Hyperthermia · 2001 Featured Publication Essential to the success of optimized thermal treatment during hyperthermia is accurate modelling. Advection of energy due to blood perfusion significantly affects the temperature. Without accurate estimates of the magnitude of the local tissue blood perfu ... Full text Link to item Cite

A case study of hyperthermia induced temperature computations in human sarcomas using discrete vasculature and relative perfusion maps

Journal Article American Society of Mechanical Engineers, Heat Transfer Division, (Publication) HTD · January 1, 2001 One of the most important technical aspects in clinical hyperthermia is the ability to measure and/or simulate the 3D temperature fields. Related to that, an essential part is the way in which the complex heat transfer related to vasculature is described. ... Cite

Piecewise fractal interpolation models to reconstruct the three-dimensional tumor perfusion

Journal Article Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings · December 1, 2000 Fractal interpolation functions (FIFs) were used to reconstruct the 3D tumor perfusion data from 2D slices obtained using DE-MRI, as an alternative to the classical interpolation means. Two FIFs techniques were used: the piece-wise self-affine fractal inte ... Cite

Hyperthermia induced 3D temperature distribution in a human sarcoma with tumor perfusion reconstructed using fractal interpolation functions

Conference ASME International Mechanical Engineering Congress and Exposition, Proceedings (IMECE) · January 1, 2000 Essential to the success of optimized thermal treatment duringhyperthermia is accurate modeling. Advection of energy due to bloodperfusion significantly perturbs the temperature and without accurateestimates of the magnitude of the local tissue blood perfu ... Full text Cite

Three-dimensional microvascular networks fractal structure: potential for tissue characterization?

Journal Article American Society of Mechanical Engineers, Bioengineering Division (Publication) BED · December 1, 1999 It has been shown that the fractal dimension of 2D microvascular networks can discriminate between normal vs. tumor tissue (Gazit et al., 1995, 1997). We have determined the fractal characteristics of five 3D microvascular networks and conclude on the corr ... Cite

Dynamic contrast-enhanced MRI and fractal characteristics of percolation clusters in two-dimensional tumor blood perfusion.

Journal Article J Biomech Eng · October 1999 Featured Publication Dynamic contrast-enhanced magnetic resonance imaging (DE-MRI) of the tumor blood pool is used to study tumor tissue perfusion. The results are then analyzed using percolation models. Percolation cluster geometry is depicted using the wash-in component of M ... Full text Link to item Cite

Computational techniques for fast hyperthermia temperature optimization.

Journal Article Med Phys · February 1999 Featured Publication Hyperthermia temperature optimization involves arriving at a temperature distribution which minimizes a stated goal function, the goal function having a biological basis in maximizing tumor cell kill while not exceeding normal tissue toxicity. This involve ... Full text Link to item Cite

THREE-DIMENSIONAL MICROVASCULAR NETWORKS FRACTAL STRUCTURE: POTENTIAL FOR TISSUE CHARACTERIZATION?

Conference ASME International Mechanical Engineering Congress and Exposition, Proceedings (IMECE) · January 1, 1999 It has been shown that the fractal dimension of 2D microvascular networks can discriminate between normal vs. tumor tissue (Gazit et al., 1995, 1997). We have determined the fractal characteristics of five 3D microvascular networks and conclude on the corr ... Full text Cite

Electromagnetic thermal therapy power optimization for multiple source applicators.

Journal Article Int J Hyperthermia · 1999 Featured Publication The optimization of power deposition for electromagnetic (EM) thermal therapy is investigated. Several goal or objective functions are examined using a generalized mathematical formulation. These include maximization of: (1) target power absorption, (2) th ... Full text Link to item Cite

Selection of coplanar or noncoplanar beams using three-dimensional optimization based on maximum beam separation and minimized nontarget irradiation.

Journal Article Int J Radiat Oncol Biol Phys · June 1, 1997 Featured Publication PURPOSE: The design of an appropriate set of multiple fixed fields to achieve a steep dose gradient at the tumor edge, with minimal normal tissue exposure, is a very difficult problem, since a virtually infinite number of possible beam orientations exists. ... Full text Link to item Cite

Hyperthermia treatment planning and temperature distribution reconstruction: a case study.

Journal Article Int J Hyperthermia · 1996 Featured Publication While a great deal of effort has been applied toward solving the technical problems associated with modelling clinical hyperthermia treatments, much of that effort has focused on only estimating the power deposition. Little effort has been applied toward u ... Full text Link to item Cite

Conformal radiation therapy with fixed shaped coplanar or noncoplanar radiation beam bouquets: a possible alternative to radiosurgery.

Journal Article Int J Radiat Oncol Biol Phys · December 1, 1995 PURPOSE: Three-dimensional (3D) geometric conformation of the therapeutic dose volume to the shape of a target tissue volume is the motivation for both conformal radiotherapy and radiosurgery. Although noncoplanar arcs have a clear physical and geometric a ... Full text Link to item Cite

Verification of a hyperthermia model method using MR thermometry.

Journal Article Int J Hyperthermia · 1995 Featured Publication Simulation of hyperthermia induced power and temperature distributions is becoming generally accepted and finding its way into clinical hyperthermia treatments. Such simulations provide a means for understanding the complete three-dimensional temperature d ... Full text Link to item Cite

Simulation of electromagnetically induced hyperthermia: a finite element gridding method.

Journal Article Int J Hyperthermia · 1995 Featured Publication A finite element gridding method for simulating electromagnetically (EM) induced hyperthermia is presented. The method uses patient CT data as its primary input, with critical structures manually outlined (on a graphics workstation) for explicit demarcatio ... Full text Link to item Cite

Application of new technology in clinical hyperthermia.

Journal Article Int J Hyperthermia · 1994 Two areas of technical progress related to hyperthermic oncology are presented: (1) numerical modelling of absorbed power and temperature distributions; and (2) non-invasive thermometry using magnetic resonance imaging. The results represent achievements m ... Full text Link to item Cite

Heating rate modeling and measurements in phantom and in vivo of the human upper extremity in a defective 2450 MHz microwave oven.

Journal Article J Microw Power Electromagn Energy · 1994 Multiple door interlock switches in commercial microwave ovens are designed to prevent accidental exposure and injury. We report a) heating rate (degree/sec) measurements in a phantom of the human upper extremity in a 2450 MHz microwave oven having interlo ... Full text Link to item Cite

Parallelization of the Volterra algorithm for linear optimal open loop control

Journal Article Computational Mechanics · July 1, 1989 If and when the time variation of optimal controls of a linear system subject to known forces is required, they can be obtained by the computationally advantageous open loop Volterra formulation (as opposed to the costlier Riccati formulation). For the com ... Full text Cite