Scholars@Duke
Sunil Vadlakonda Rao

Sunil Vadlakonda Rao

Adjunct Professor in the Department of Medicine
Medicine, Cardiology
VA Medical Center, 508 Fulton Street (111A), Durham, NC 27705

Selected Publications

Characterization of peripheral artery disease and associations with traditional risk factors, mobility, and biomarkers in the project baseline health study.

Journal Article Am Heart J · September 2024 BACKGROUND: There is a dearth of research on immunophenotyping in peripheral artery disease (PAD). This study aimed to describe the baseline characteristics, immunophenotypic profile, and quality of life (QoL) of participants with PAD in the Project Baseli ... Full text Link to item Cite

Procedural Outcomes With Femoral, Radial, Distal Radial, and Ulnar Access for Coronary Angiography: A Network Meta-Analysis.

Journal Article Circ Cardiovasc Interv · September 2024 BACKGROUND: Radial artery access for coronary angiography or percutaneous coronary intervention (PCI) reduces the risk of death, bleeding, and vascular complications and is preferred over femoral artery access, leading to a class 1 indication by clinical p ... Full text Link to item Cite

Impact of anemia on outcomes and resource utilization in patients with myocardial infarction: A national database analysis.

Journal Article Int J Cardiol · August 1, 2024 BACKGROUND: Although anemia is common in patients with myocardial infarction (MI), management remains controversial. We quantified the association of anemia with in-hospital outcomes and resource utilization in patients admitted with MI using a large natio ... Full text Link to item Cite

American Heart Association Cardiogenic Shock Registry: Design and Implementation.

Journal Article Circ Cardiovasc Qual Outcomes · July 2024 BACKGROUND: Cardiogenic shock is a morbid complication of heart disease that claims the lives of more than 1 in 3 patients presenting with this syndrome. Supporting a unique collaboration across clinical specialties, federal regulators, payors, and industr ... Full text Link to item Cite

Culprit-Only Revascularization, Single-Setting Complete Revascularization, and Staged Complete Revascularization in Acute Myocardial Infarction: Insights From a Mixed Treatment Comparison Meta-Analysis of Randomized Trials.

Journal Article Circ Cardiovasc Interv · July 2024 BACKGROUND: Complete revascularization improves cardiovascular outcomes compared with culprit-only revascularization in patients with acute myocardial infarction ([MI]; ST-segment-elevation MI or non-ST-segment-elevation MI) and multivessel coronary artery ... Full text Link to item Cite

Polyvascular Disease: A Narrative Review of Risk Factors, Clinical Outcomes and Treatment.

Journal Article Curr Cardiol Rep · June 2024 PURPOSE OF REVIEW: Polyvascular disease has a significant global burden and is associated with increased risk of major adverse cardiac events with each additional vascular territory involved. The purpose of this review is to highlight the risk factors, ass ... Full text Link to item Cite

Case Volumes and Outcomes Among Early-Career Interventional Cardiologists in the United States.

Journal Article J Am Coll Cardiol · May 21, 2024 BACKGROUND: Little is known about the procedural characteristics, case volumes, and mortality rates for early- vs non-early-career interventional cardiologists in the United States. OBJECTIVES: This study examined operator-level data for patients who under ... Full text Link to item Cite

Burnout in Cardiology: A Narrative Review

Journal Article Journal of Invasive Cardiology · May 1, 2024 The frequency of burnout is rising among cardiologists, affecting not only their well-being but also the quality of patient care. Computerization of practice, bureaucracy, excessive workload, lack of control/autonomy, hostile and hectic work environments, ... Full text Cite

Frailty and In-Hospital Outcomes for Management of Cardiogenic Shock without Acute Myocardial Infarction.

Journal Article J Clin Med · April 3, 2024 (1) Background: Cardiogenic shock (CS) is associated with high morbidity and mortality. Frailty and cardiovascular diseases are intertwined, commonly sharing risk factors and exhibiting bidirectional relationships. The relationship of frailty and non-acute ... Full text Open Access Link to item Cite

Evaluating registry-based trial economics: Results from the STRESS clinical trial.

Journal Article Contemp Clin Trials Commun · April 2024 BACKGROUND: Registry-based trials have the potential to reduce randomized clinical trial (RCT) costs. However, observed cost differences also may be achieved through pragmatic trial designs. A systematic comparison of trial costs across different designs h ... Full text Link to item Cite

One-month DAPT with ticagrelor and aspirin for patients undergoing coronary artery bypass grafting: rationale and design of the randomised, multicentre, double-blind, placebo-controlled ODIN trial.

Journal Article EuroIntervention · March 4, 2024 The optimal antiplatelet strategy after coronary artery bypass graft (CABG) surgery in patients with chronic coronary syndromes (CCS) is unclear. Adding the P2Y12 inhibitor, ticagrelor, to low-dose aspirin for 1 year is associated with a reduction in graft ... Full text Link to item Cite

Coronary Microvascular Dysfunction

Journal Article Journal of the Society for Cardiovascular Angiography and Interventions · March 1, 2024 Full text Cite

Implementation of a Multidimensional Strategy to Reduce Post-PCI Bleeding Risk.

Journal Article Circ Cardiovasc Interv · March 2024 BACKGROUND: The American College of Cardiology Reduce the Risk: PCI Bleed Campaign was a hospital-based quality improvement campaign designed to reduce post-percutaneous coronary intervention (PCI) bleeding events. The aim of the campaign was to provide ac ... Full text Link to item Cite

Bleeding Outcomes in Patients Treated With Asundexian in Phase II Trials.

Journal Article J Am Coll Cardiol · February 13, 2024 BACKGROUND: Phase II trials of asundexian were underpowered to detect important differences in bleeding. OBJECTIVES: The goal of this study was to obtain best estimates of effects of asundexian vs active control/placebo on major and clinically relevant non ... Full text Link to item Cite

Use of Calcium Modification During Percutaneous Coronary Intervention After Introduction of Coronary Intravascular Lithotripsy.

Journal Article J Soc Cardiovasc Angiogr Interv · February 2024 BACKGROUND: Calcified coronary lesions are a challenge for percutaneous coronary interventions (PCIs). Coronary intravascular lithotripsy (IVL) is a novel calcium modification technology approved for commercial use in February 2021, but little is known abo ... Full text Link to item Cite

Editorial: The need for standardized feedback systems for interventional cardiologists

Journal Article Cardiovascular Revascularization Medicine · January 1, 2024 Full text Cite

Restrictive or Liberal Transfusion Strategy in Myocardial Infarction and Anemia.

Journal Article N Engl J Med · December 28, 2023 BACKGROUND: A strategy of administering a transfusion only when the hemoglobin level falls below 7 or 8 g per deciliter has been widely adopted. However, patients with acute myocardial infarction may benefit from a higher hemoglobin level. METHODS: In this ... Full text Link to item Cite

Management of Adults With Anomalous Aortic Origin of the Coronary Arteries: State-of-the-Art Review.

Journal Article Ann Thorac Surg · December 2023 As a result of increasing adoption of imaging screening, the number of adult patients with a diagnosis of anomalous aortic origin of the coronary arteries (AAOCA) has grown in recent years. Existing guidelines provide a framework for management and treatme ... Full text Link to item Cite

Intravascular imaging during percutaneous coronary intervention: temporal trends and clinical outcomes in the USA.

Journal Article Eur Heart J · October 12, 2023 AIMS: Prior trials have demonstrated that intravascular imaging (IVI)-guided percutaneous coronary intervention (PCI) results in less frequent target lesion revascularization and major adverse cardiovascular events (MACEs) compared with standard angiograph ... Full text Link to item Cite

Thrombotic risk in patients with acute coronary syndromes discharged on prasugrel or clopidogrel: results from the PROMETHEUS study.

Journal Article Eur Heart J Acute Cardiovasc Care · September 25, 2023 AIMS: Based on recent clinical data, the 2020 ESC guidelines on non-ST-elevation acute coronary syndrome (NSTE-ACS) suggest to tailor antithrombotic strategy on individual thrombotic risk. Nonetheless, prevalence and prognostic impact of the high thromboti ... Full text Link to item Cite

Acute Myocardial Infarction: Etiologies and Mimickers in Young Patients.

Journal Article J Am Heart Assoc · September 19, 2023 Acute myocardial infarction is an important cause of death worldwide. While it often affects patients of older age, acute myocardial infarction is garnering more attention as a significant cause of morbidity and mortality among young patients (<45 years of ... Full text Link to item Cite

Pulmonary Artery Catheter Use and Outcomes in Patients With ST-Elevation Myocardial Infarction and Cardiogenic Shock Treated With Impella (a Nationwide Analysis from the United States).

Journal Article Am J Cardiol · September 15, 2023 The role of continuous hemodynamic assessment with pulmonary artery (PA) catheter placement in cardiogenic shock (CS) remains debated. We aimed to assess the association between PA catheter placement and clinical outcomes in patients with CS secondary to S ... Full text Link to item Cite

Preoperative frailty and adverse outcomes following coronary artery bypass grafting surgery in US veterans.

Journal Article J Am Geriatr Soc · September 2023 BACKGROUND: Contemporary guidelines emphasize the value of incorporating frailty into clinical decision-making regarding revascularization strategies for coronary artery disease. Yet, there are limited data describing the association between frailty and lo ... Full text Link to item Cite

Comparison of intravascular ultrasound, optical coherence tomography, and conventional angiography-guided percutaneous coronary interventions: A systematic review, network meta-analysis, and meta-regression.

Journal Article Catheter Cardiovasc Interv · September 2023 BACKGROUND: Intracoronary imaging modalities, including intravascular ultrasound (IVUS) and optical coherence tomography (OCT), provide valuable supplemental data unavailable on coronary angiography (CA) and have shown to improve clinical outcomes. We soug ... Full text Link to item Cite

Complete Revascularization Versus Culprit-Lesion-Only PCI in STEMI Patients With Diabetes and Multivessel Coronary Artery Disease: Results From the COMPLETE Trial.

Journal Article Circ Cardiovasc Interv · September 2023 BACKGROUND: In the COMPLETE trial (Complete Versus Culprit-Only Revascularization to Treat Multivessel Disease After Early PCI for STEMI), a strategy of complete revascularization reduced the risk of major cardiovascular events compared with culprit-lesion ... Full text Link to item Cite

Chronic Coronary Disease Guidelines.

Journal Article Circulation · August 29, 2023 Full text Link to item Cite

No-reflow after primary percutaneous coronary intervention in patients with ST-elevation myocardial infarction: an angiographic core laboratory analysis of the TOTAL Trial.

Journal Article EuroIntervention · August 7, 2023 BACKGROUND: The optimal strategy to prevent no-reflow in ST-elevation myocardial infarction (STEMI) patients undergoing percutaneous coronary intervention (PCI) is unknown. AIMS: We aimed to examine the effect of thrombectomy on the outcome of no-reflow in ... Full text Link to item Cite

Vascular Access in Percutaneous Coronary Intervention of Chronic Total Occlusions: A State-of-the-Art Review.

Journal Article Circ Cardiovasc Interv · August 2023 The outcomes of chronic total occlusion percutaneous coronary intervention have considerably improved during the last decade with continued emphasis on improving procedural safety. Vascular access site bleeding remains one of the most frequent complication ... Full text Link to item Cite

Lifting the Regulatory Blanket Off of Covered Stents.

Journal Article Cardiovasc Revasc Med · July 2023 Full text Link to item Cite

Outcomes With Percutaneous Debulking of Tricuspid Valve Endocarditis.

Journal Article Circ Cardiovasc Interv · July 2023 BACKGROUND: In patients with tricuspid valve infective endocarditis, percutaneous debulking is a treatment option. However, the outcomes of this approach are less well known. METHODS: We performed a retrospective analysis of all patients who underwent perc ... Full text Link to item Cite

Outcomes and Institutional Variation in Arterial Access Among Patients With AMI and Cardiogenic Shock Undergoing PCI.

Journal Article JACC Cardiovasc Interv · June 26, 2023 BACKGROUND: Contemporary data comparing the outcomes of transradial access (TRA) vs transfemoral access (TFA) among patients presenting with acute myocardial infarction and cardiogenic shock (AMI-CS) undergoing percutaneous coronary intervention (PCI) are ... Full text Link to item Cite

Defining Strategies of Modulation of Antiplatelet Therapy in Patients With Coronary Artery Disease: A Consensus Document from the Academic Research Consortium.

Journal Article Circulation · June 20, 2023 Antiplatelet therapy is the mainstay of pharmacologic treatment to prevent thrombotic or ischemic events in patients with coronary artery disease treated with percutaneous coronary intervention and those treated medically for an acute coronary syndrome. Th ... Full text Link to item Cite

Leveraging electronic health records to streamline the conduct of cardiovascular clinical trials.

Journal Article Eur Heart J · June 1, 2023 Conventional randomized controlled trials (RCTs) can be expensive, time intensive, and complex to conduct. Trial recruitment, participation, and data collection can burden participants and research personnel. In the past two decades, there have been rapid ... Full text Link to item Cite

Same day discharge versus overnight observation following chronic total occlusion percutaneous coronary intervention: Insights from the PROGRESS-CTO registry.

Journal Article Catheter Cardiovasc Interv · May 2023 BACKGROUND: Same day discharge (SDD) following chronic total occlusion (CTO) percutaneous coronary intervention (PCI) has received limited study. METHODS: We evaluated the clinical, angiographic, and procedural characteristics of patients discharged the sa ... Full text Link to item Cite

In-hospital Outcomes of Patients With and Without Previous Coronary Artery Bypass Graft Surgery Who Present With a Non-ST-Segment Elevation Myocardial Infarction.

Journal Article Am J Cardiol · May 1, 2023 The clinical course of patients with a previous coronary artery bypass graft surgery (CABG) presenting with non-ST-elevation myocardial infarction (NSTEMI) is not well defined. We aimed to compare the management and outcomes of patients with and without pr ... Full text Link to item Cite

Particulate Matter Air Pollution and Long-Term Outcomes in Patients Undergoing Percutaneous Coronary Intervention

Journal Article JACC: Advances · May 1, 2023 Background: Fine particulate matter (PM2.5) promotes atherosclerosis progression and plaque vulnerability. Consequently, patients with a high atherosclerotic burden may be at especially increased risk when exposed to air pollution. Objectives: The purpose ... Full text Cite

Rationale and design for the myocardial ischemia and transfusion (MINT) randomized clinical trial.

Journal Article Am Heart J · March 2023 BACKGROUND: Accumulating evidence from clinical trials suggests that a lower (restrictive) hemoglobin threshold (<8 g/dL) for red blood cell (RBC) transfusion, compared with a higher (liberal) threshold (≥10 g/dL) is safe. However, in anemic patients with ... Full text Link to item Cite

Real-World Examination of Revascularization Strategies for Left Main Coronary Disease in Ontario, Canada.

Journal Article JACC Cardiovasc Interv · February 13, 2023 BACKGROUND: Randomized trials have compared percutaneous coronary intervention and coronary artery bypass grafting (CABG) in patients with left main coronary artery disease undergoing nonemergent revascularization. However, there is a paucity of real-world ... Full text Link to item Cite

Clinical Significance of Culprit Vessel Occlusion in Patients With Non-ST-Elevation Myocardial Infarction Who Underwent Percutaneous Coronary Intervention.

Journal Article Am J Cardiol · February 1, 2023 In patients with non-ST-elevation myocardial infarction (NSTEMI), total occlusion of the culprit coronary artery (OCA) is not uncommon. We sought to determine the frequency and clinical impact of OCA at presentation in a large population of patients presen ... Full text Link to item Cite

Optimal Hemostatic Band Duration After Transradial Angiography or Intervention: Insights From a Mixed Treatment Comparison Meta-Analysis of Randomized Trials.

Journal Article Circ Cardiovasc Interv · February 2023 BACKGROUND: The optimal duration of hemostatic compression post transradial access is controversial. Longer duration increases the risk of radial artery occlusion (RAO) while shorter duration increases the risk of access site bleeding or hematoma. As such, ... Full text Link to item Cite

Comparing the Classification of Percutaneous Coronary Interventions Using the 2012 and 2017 Appropriate Use Criteria: Insights From 245,196 Patients in the NCDR CathPCI Registry.

Journal Article Am Heart J · January 2023 BACKGROUND: Appropriate use criteria (AUC) have been developed to promote the rational use of percutaneous coronary intervention (PCI) among clinicians and to provide benchmarking feedback to hospitals. The original AUC were published in 2012 and subsequen ... Full text Link to item Cite

SCAI Expert Consensus Statement on Management of In-Stent Restenosis and Stent Thrombosis.

Journal Article J Soc Cardiovasc Angiogr Interv · 2023 Stent failure remains the major drawback to the use of coronary stents as a revascularization strategy. Recent advances in imaging have substantially improved our understanding of the mechanisms underlying these occurrences, which have in common numerous c ... Full text Link to item Cite

P2Y12 inhibitor monotherapy in patients undergoing percutaneous coronary intervention.

Journal Article Nat Rev Cardiol · December 2022 For 20 years, dual antiplatelet therapy (DAPT), consisting of the combination of aspirin and a platelet P2Y12 receptor inhibitor, has been the gold standard of antithrombotic pharmacology after percutaneous coronary intervention (PCI). In the past 5 years, ... Full text Link to item Cite

Distal vs Conventional Radial Access for Coronary Angiography and/or Intervention: A Meta-Analysis of Randomized Trials.

Journal Article JACC Cardiovasc Interv · November 28, 2022 BACKGROUND: Emerging evidence from randomized clinical trials (RCTs) comparing distal radial access (DRA) with conventional radial access (RA) is available. OBJECTIVES: The aim of this study was to provide a quantitative appraisal of the effects of DRA) vs ... Full text Link to item Cite

Effects on Mortality and Major Bleeding of Radial Versus Femoral Artery Access for Coronary Angiography or Percutaneous Coronary Intervention: Meta-Analysis of Individual Patient Data From 7 Multicenter Randomized Clinical Trials.

Journal Article Circulation · November 2022 BACKGROUND: In some randomized clinical trials, transradial access (TRA) compared with transfemoral access (TFA) was associated with lower mortality in patients with coronary artery disease undergoing invasive management. We analyzed the effects of TRA ver ... Full text Link to item Cite

Complete Revascularization vs Culprit Lesion-Only Percutaneous Coronary Intervention for Angina-Related Quality of Life in Patients With ST-Segment Elevation Myocardial Infarction: Results From the COMPLETE Randomized Clinical Trial.

Journal Article JAMA Cardiol · November 1, 2022 IMPORTANCE: In patients with multivessel coronary artery disease (CAD) presenting with ST-segment elevation myocardial infarction (STEMI), complete revascularization reduces major cardiovascular events compared with culprit lesion-only percutaneous coronar ... Full text Link to item Cite

A Multicenter, Phase 2, Randomized, Placebo-Controlled, Double-Blind, Parallel-Group, Dose-Finding Trial of the Oral Factor XIa Inhibitor Asundexian to Prevent Adverse Cardiovascular Outcomes After Acute Myocardial Infarction.

Journal Article Circulation · October 18, 2022 BACKGROUND: Oral activated factor XI (FXIa) inhibitors may modulate coagulation to prevent thromboembolic events without substantially increasing bleeding. We explored the pharmacodynamics, safety, and efficacy of the oral FXIa inhibitor asundexian for sec ... Full text Link to item Cite

Position Statement on Vascular Access Safety for Percutaneous Devices in AMI Complicated by Cardiogenic Shock.

Journal Article JACC. Cardiovascular interventions · October 2022 In the United States, the frequency of using percutaneous mechanical circulatory support devices for acute myocardial infarction complicated by cardiogenic shock is increasing. These devices require large-bore vascular access to provide left, right, or biv ... Full text Cite

Extended, standard, or De-escalation antiplatelet therapy for patients with coronary artery disease undergoing percutaneous coronary intervention? A trial-sequential, bivariate, influential, and network meta-analysis.

Journal Article Eur Heart J Cardiovasc Pharmacother · September 29, 2022 AIMS: The relative safety and efficacy of de-escalation, extended duration (ED) (>12-months), and standard dual antiplatelet therapy for 12-months (DAPT-12) in patients with coronary artery disease (CAD) undergoing percutaneous coronary intervention (PC ... Full text Link to item Cite

Shortening the duration of dual antiplatelet therapy after percutaneous coronary intervention for acute coronary syndrome: A systematic review and meta-analysis.

Journal Article Am Heart J · September 2022 INTRODUCTION: The decision to shorten the duration of DAPT following PCI in patients with ACS remains controversial because of the concern for increased ischemic events. METHODS: We performed a comprehensive literature search in seven databases to explore ... Full text Link to item Cite

Dual antiplatelet therapy duration after percutaneous coronary intervention using drug eluting stents in high bleeding risk patients: A systematic review and meta-analysis.

Journal Article Am Heart J · August 2022 BACKGROUND: Optimal dual antiplatelet therapy (DAPT) duration in patients at high bleeding risk (HBR) is not fully defined. We aimed to compare the safety and effectiveness of short-term DAPT (S-DAPT) with longer duration DAPT (L-DAPT) after percutaneous c ... Full text Link to item Cite

Sex-Based Differences in Periprocedural Complications Following Lower Extremity Peripheral Vascular Intervention.

Journal Article Circ Cardiovasc Interv · August 2022 BACKGROUND: Women with coronary artery disease are shown to have worse outcomes after percutaneous coronary intervention compared with men; however, less is known about sex-based outcomes following lower extremity peripheral vascular intervention (PVI) for ... Full text Link to item Cite

Iso-osmolar versus low-osmolar contrast media and outcomes after percutaneous coronary intervention: Insights from the VA CART Program.

Journal Article Catheter Cardiovasc Interv · July 2022 OBJECTIVES: To assess whether contrast media type is associated with outcomes in veterans undergoing percutaneous coronary intervention (PCI). BACKGROUND: There is uncertainty about the impact of iso-osmolar contrast medium (IOCM) versus low-osmolar contra ... Full text Link to item Cite

Trends in Arterial Access Site Selection and Bleeding Outcomes Following Coronary Procedures, 2011-2018.

Journal Article Circ Cardiovasc Qual Outcomes · May 2022 BACKGROUND: Prior studies of radial access for cardiac catheterization have focused on early adopters of the technique, and some have described a risk/treatment paradox of low radial access use among high bleeding risk patients. This study aimed to determi ... Full text Link to item Cite

Prophylactic Mechanical Circulatory Support Use in Elective Percutaneous Coronary Intervention for Patients With Stable Coronary Artery Disease.

Journal Article Circulation. Cardiovascular interventions · May 2022 BackgroundMechanical circulatory support (MCS) devices can be used in high-risk percutaneous coronary intervention (PCI). Our objective was to describe trends and outcomes of prophylactic MCS use in elective PCI for patients with stable coronary a ... Full text Cite

2021 ACC/AHA/SCAI Coronary Artery Revascularization Guidelines for Managing the Nonculprit Artery in STEMI.

Journal Article JACC Case Rep · April 6, 2022 The 2021 Coronary Artery Disease revascularization guidelines of the American College of Cardiology (ACC), the American Heart Association (AHA), and the Society for Cardiovascular Angiography and Interventions (SCAI) provide recommendations for managing no ... Full text Link to item Cite

Electronic alerts to initiate anticoagulation dialogue in patients with atrial fibrillation.

Journal Article Am Heart J · March 2022 IMPORTANCE: The benefit of an electronic support system for the prescription and adherence to oral anticoagulation therapy among patients with atrial fibrillation (AF) and atrial flutter at heightened risk for of stroke and systemic thromboembolism is uncl ... Full text Link to item Cite

Bleeding avoidance strategies in percutaneous coronary intervention.

Journal Article Nat Rev Cardiol · February 2022 For many years, bleeding has been perceived as an unavoidable consequence of strategies aimed at reducing thrombotic complications in patients undergoing percutaneous coronary intervention (PCI). However, the paradigm has now shifted towards bleeding being ... Full text Link to item Cite

Radial versus femoral access in patients with coronary artery bypass surgery: Frequentist and Bayesian meta-analysis.

Journal Article Catheter Cardiovasc Interv · February 2022 BACKGROUND: The optimal access site for cardiac catheterization in patients with prior coronary artery bypass surgery (CABG) continues to be debated. METHODS: We performed a random effects frequentist and Bayesian meta-analysis of 4 randomized trials and 1 ... Full text Link to item Cite

2021 ACC/AHA/SCAI Guideline for Coronary Artery Revascularization: Executive Summary: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines

Journal Article Journal of the American College of Cardiology · January 18, 2022 Aim: The executive summary of the American College of Cardiology/American Heart Association/Society for Cardiovascular Angiography and Interventions coronary artery revascularization guideline provides the top 10 items readers should know about the guideli ... Full text Cite

2021 ACC/AHA/SCAI Guideline for Coronary Artery Revascularization: Executive Summary: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines.

Journal Article Circulation · January 18, 2022 AIM: The executive summary of the American College of Cardiology/American Heart Association/Society for Cardiovascular Angiography and Interventions coronary artery revascularization guideline provides the top 10 items readers should know about the guideli ... Full text Link to item Cite

2021 ACC/AHA/SCAI Guideline for Coronary Artery Revascularization: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines

Journal Article Journal of the American College of Cardiology · January 18, 2022 Aim: The guideline for coronary artery revascularization replaces the 2011 coronary artery bypass graft surgery and the 2011 and 2015 percutaneous coronary intervention guidelines, providing a patient-centric approach to guide clinicians in the treatment o ... Full text Cite

The bleeding risk treatment paradox at the physician and hospital level: Implications for reducing bleeding in patients undergoing percutaneous coronary intervention.

Journal Article Am Heart J · January 2022 BACKGROUND: Bleeding is a common and costly complication of percutaneous coronary intervention (PCI). Bleeding avoidance strategies (BAS) are used paradoxically less in patients at high-risk of bleeding: "bleeding risk-treatment paradox" (RTP). We determin ... Full text Link to item Cite

In-Stent Restenosis in Saphenous Vein Grafts (from the DIVA Trial).

Journal Article Am J Cardiol · January 1, 2022 Saphenous vein grafts (SVGs) have high rates of in-stent restenosis (ISR). We compared the baseline clinical and angiographic characteristics of patients and lesions that did develop ISR with those who did not develop ISR during a median follow-up of 2.7 y ... Full text Link to item Cite

Percutaneous Coronary Intervention Operator Profiles and Associations With In-Hospital Mortality.

Journal Article Circ Cardiovasc Interv · January 2022 BACKGROUND: Percutaneous coronary intervention is performed by operators with differing experience, technique, and case mix. It is unknown if operator practice patterns impact patient outcomes. We sought to determine if a cluster algorithm can identify dis ... Full text Link to item Cite

Access Site Selection and Outcomes for Chronic Total Occlusion Percutaneous Coronary Interventions: Insights from the VA CART Program.

Journal Article J Soc Cardiovasc Angiogr Interv · 2022 BACKGROUND: There has been increasing use of transradial access (TRA) for non-chronic total occlusion (CTO) percutaneous coronary intervention (PCI). There are limited data on TRA for CTO PCI. The objectives of this study were to assess the temporal trends ... Full text Link to item Cite

Clinical Characteristics, Outcomes, and Epidemiological Trends of Patients Admitted With Type 2 Myocardial Infarction.

Journal Article J Soc Cardiovasc Angiogr Interv · 2022 BACKGROUND: Type 2 myocardial infarction (T2MI) was first established as a unique entity in 2007. However, its clinical features are not well characterized. This study aimed to determine the clinical characteristics, predictors of mortality, and hospitaliz ... Full text Link to item Cite

Design and baseline results of a coaching intervention for implementation of trans-radial access in percutaneous coronary intervention.

Journal Article Contemp Clin Trials · December 2021 Trans-radial artery access (TRA) for cardiac catheterization and percutaneous coronary intervention has many advantages over trans-femoral artery access (TFA), but implementation has been slow. The steep learning curve, logistical issues, and radiation exp ... Full text Link to item Cite

Hot topics in interventional cardiology: Proceedings from the society for cardiovascular angiography and interventions (SCAI) 2021 think tank.

Journal Article Catheter Cardiovasc Interv · November 1, 2021 The Society for Cardiovascular Angiography and Interventions (SCAI) Think Tank is a collaborative venture that brings together interventional cardiologists, administrative partners, and select members of the cardiovascular industry community annually for h ... Full text Link to item Cite

Cardiogenic Shock After Acute Myocardial Infarction: A Review.

Journal Article JAMA · November 2021 ImportanceCardiogenic shock affects between 40 000 and 50 000 people in the US per year and is the leading cause of in-hospital mortality following acute myocardial infarction.ObservationsThirty-day mortality for patients with cardiogenic ... Full text Cite

Cost analysis of a coaching intervention to increase use of transradial percutaneous coronary intervention.

Journal Article Implement Sci Commun · October 27, 2021 BACKGROUND: The transradial approach (TRA) to cardiac catheterization is safer than the traditional transfemoral approach (TFA), with similar clinical effectiveness. However, adoption of TRA remains low, representing less than 50% of catheterization proced ... Full text Link to item Cite

Bridging Antiplatelet Therapy After Percutaneous Coronary Intervention: JACC Review Topic of the Week.

Journal Article J Am Coll Cardiol · October 12, 2021 Patients undergoing early surgery after coronary stent implantation are at increased risk for mortality from ischemic and hemorrhagic complications. The optimal antiplatelet strategy in patients who cannot discontinue dual antiplatelet therapy (DAPT) befor ... Full text Link to item Cite

Outcomes in non-ST-segment elevation myocardial infarction patients according to heart failure at admission: Insights from a large trial with systematic early invasive strategy.

Journal Article Eur Heart J Acute Cardiovasc Care · October 1, 2021 BACKGROUND: Previous studies published before the era of systematic early invasive strategy have reported a higher mortality in non-ST-segment elevation myocardial infarction patients with heart failure. The aim of our study was to compare the clinical cha ... Full text Link to item Cite

Saphenous Vein Graft Failure: From Pathophysiology to Prevention and Treatment Strategies.

Journal Article Circulation · August 31, 2021 Saphenous vein grafts (SVGs) remain the most frequently used conduits in coronary artery bypass graft surgery (CABG). Despite advances in surgical techniques and pharmacotherapy, SVG failure rates remain high, often leading to repeat coronary revasculariza ... Full text Link to item Cite

Trends in Use and Outcomes of Same-Day Discharge Following Elective Percutaneous Coronary Intervention.

Journal Article JACC Cardiovasc Interv · August 9, 2021 OBJECTIVES: The aims of this study were to describe trends and hospital variation in same-day discharge following elective percutaneous coronary intervention (PCI) and to evaluate the association between trends in same-day discharge and patient outcomes. B ... Full text Link to item Cite

Evidence-Based Practices in the Cardiac Catheterization Laboratory: A Scientific Statement From the American Heart Association.

Journal Article Circulation · August 3, 2021 Cardiac catheterization procedures have rapidly evolved and expanded in scope and techniques over the past few decades. However, although some practices have emerged based on evidence, many traditions have persisted based on beliefs and theoretical concern ... Full text Link to item Cite

Venous thromboembolism among patients hospitalized with COVID-19 at Veterans Health Administration Hospitals.

Journal Article Am Heart J · July 2021 Patients with coronavirus disease 2019 (COVID-19) are at heightened risk of venous thromboembolic events (VTE), though there is no data examining when these events occur following a COVID-19 diagnosis. We therefore sought to characterize the incidence, tim ... Full text Link to item Cite

Drug-coated stents versus bare metal stents in Academic Research Consortium-defined high bleeding risk patients.

Journal Article EuroIntervention · June 25, 2021 BACKGROUND: More effective and progressively safer generations of drug-elut-ing stents (DES) have replaced bare metal stents (BMS) in rou-tine clinical practice. However, patients considered to be at high bleeding risk (HBR) have traditionally been underre ... Full text Link to item Cite

Quo Vadis, Bleeding Risk Models?

Journal Article JACC Cardiovasc Interv · June 14, 2021 Full text Link to item Cite

Coronary Artery Disease Evaluation and Management Considerations for High Risk Occupations: Commercial Vehicle Drivers and Pilots.

Journal Article Circ Cardiovasc Interv · June 2021 Optimal treatment of stable ischemic heart disease for those in the transportation industry is considered in the context of the individual's health, as well as with the perspective that sudden impairment could have catastrophic consequences for others. Thi ... Full text Link to item Cite

Real-World Data on the Intravascular Microaxial Left Ventricular Flow Pump (Impella) in High-Risk Patients.

Journal Article Korean Circ J · June 2021 Mechanical circulatory support (MCS) devices maintain or improve hemodynamic profiles in patients at risk for hemodynamic deterioration during percutaneous coronary intervention (PCI) or those in cardiogenic shock. Clinical trials of MCS have been difficul ... Full text Link to item Cite

Percutaneous coronary intervention in patients with stable coronary artery disease and left ventricular systolic dysfunction: insights from the VA CART program.

Journal Article Am Heart J · May 2021 BACKGROUND: Revascularization of ischemic cardiomyopathy by coronary artery bypass grafting has been shown to improve survival among patients with left ventricular ejection fraction (LVEF) ≤35%, but the role of percutaneous coronary intervention (PCI) in t ... Full text Link to item Cite

Interventional cardiologists' perceptions of percutaneous coronary intervention quality measurement and feedback.

Journal Article Am Heart J · May 2021 BACKGROUND: Interventional cardiologists receive feedback on their clinical care from a variety of sources including registry-based quality measures, case conferences, and informal peer interactions. However, the impact of this feedback on clinical care is ... Full text Link to item Cite

Characteristics and Outcomes of Patients With History of CABG Undergoing Cardiac Catheterization Via the Radial Versus Femoral Approach.

Journal Article JACC Cardiovasc Interv · April 26, 2021 OBJECTIVES: The aims of this study were to examine rates of radial artery access in post-coronary artery bypass grafting (CABG) patients undergoing diagnostic catherization and/or percutaneous coronary intervention (PCI), whether operators with higher proc ... Full text Link to item Cite

Invasive Management of Acute Myocardial Infarction Complicated by Cardiogenic Shock: A Scientific Statement From the American Heart Association.

Journal Article Circulation · April 13, 2021 Cardiogenic shock (CS) remains the most common cause of mortality in patients with acute myocardial infarction. The SHOCK trial (Should We Emergently Revascularize Occluded Coronaries for Cardiogenic Shock) demonstrated a survival benefit with early revasc ... Full text Link to item Cite

The association between coronary graft patency and clinical status in patients with coronary artery disease.

Journal Article Eur Heart J · April 7, 2021 The concept of a direct association between coronary graft patency and clinical status is generally accepted. However, the relationship is more complex and variable than usually thought. Key issues are the lack of a common definition of graft occlusion and ... Full text Link to item Cite

Ventricular Fibrillation Due to Aortocoronary Vein Graft Spasm During Angiography: Case Report and Literature Review.

Journal Article JACC Case Rep · March 2021 A 69-year-old man underwent coronary angiography 7 years after coronary artery bypass. Saphenous vein graft spasm was observed during contrast injection, resulting in ventricular fibrillation. Angiography 6 years later showed graft patency. Vein graft spas ... Full text Link to item Cite

Survival and Causes of Death Among Veterans With Lower Extremity Revascularization With Paclitaxel-Coated Devices: Insights From the Veterans Health Administration.

Journal Article J Am Heart Assoc · February 16, 2021 BACKGROUND The long-term safety of paclitaxel-coated devices (PCDs; drug-coated balloon or drug-eluting stent) for peripheral endovascular intervention is uncertain. We used data from the Veterans Health Administration to evaluate the association between P ... Full text Link to item Cite

Algorithms for challenging scenarios encountered in transradial intervention.

Journal Article Indian Heart J · 2021 Transradial intervention (TRI) was first introduced by Lucien Campeau in 1989 and since then has created a lasting impact in the field of interventional cardiology. Several studies have demonstrated that TRI is associated with fewer vascular site complicat ... Full text Link to item Cite

Overcoming Obstacles in Designing and Sustaining a High-Quality Cardiovascular Procedure Environment.

Journal Article JACC Cardiovasc Interv · December 14, 2020 Accurate evaluation of the quality of invasive cardiology procedures requires appraisal of case selection, technical performance, and procedural and clinical outcomes. Regrettably, the medical care delivery system poses a number of obstacles to developing ... Full text Link to item Cite

Oral Antiplatelet Therapy Administered Upstream to Patients With NSTEMI.

Journal Article Crit Pathw Cardiol · December 2020 OBJECTIVE: To describe from a noninterventional registry (Utilization of Ticagrelor in the Upstream Setting for Non-ST-Segment Elevation Acute Coronary Syndrome), the short-term ischemic and hemorrhagic outcomes in patients with non-ST elevation myocardial ... Full text Link to item Cite

Association of plasma pentraxin 3 concentration with angiographic and clinical outcomes in patients with acute ST-segment elevation myocardial infarction treated by primary angioplasty.

Journal Article Catheter Cardiovasc Interv · November 2020 OBJECTIVE: To evaluate the association of plasma long pentraxin 3 (PTX3) concentration with angiographic and clinical outcomes in patients with acute ST-segment elevation myocardial infarction (STEMI) treated by primary angioplasty. BACKGROUND: Whether con ... Full text Link to item Cite

Meta-analysis of bivalirudin versus heparin in transradial coronary interventions.

Journal Article Catheter Cardiovasc Interv · November 2020 OBJECTIVES: We sought to evaluate the efficacy and safety of bivalirudin versus heparin in patients with coronary artery disease undergoing transradial artery coronary intervention (TRI). BACKGROUND: Bivalirudin and radial artery access are independently a ... Full text Link to item Cite

Early vs Late Discharge in Low-Risk ST-Elevation Myocardial Infarction Patients Treated With Percutaneous Coronary Intervention: A Systematic Review and Meta-Analysis.

Journal Article Cardiovasc Revasc Med · November 2020 BACKGROUND: For low-risk patients with ST-elevation myocardial infarction (STEMI) undergoing percutaneous coronary intervention (PCI) the recommended optimal discharge timing is inconsistent in guidelines. The European Society of Cardiology guidelines reco ... Full text Link to item Cite

Blood transfusion and ischaemic outcomes according to anemia and bleeding in patients with non-ST-segment elevation acute coronary syndromes: Insights from the TAO randomized clinical trial.

Journal Article Int J Cardiol · November 1, 2020 BACKGROUND: The benefits and risks of blood transfusion in patients with acute myocardial infarction who are anemic or who experience bleeding are debated. We sought to study the association between blood transfusion and ischemic outcomes according to haem ... Full text Link to item Cite

Hot topics in interventional cardiology: Proceedings from the society for cardiovascular angiography and interventions 2020 think tank.

Journal Article Catheter Cardiovasc Interv · November 2020 The society for cardiovascular angiography and interventions (SCAI) think tank is a collaborative venture that brings together interventional cardiologists, administrative partners, and select members of the cardiovascular industry community for high-level ... Full text Link to item Cite

Currently Available Options for Mechanical Circulatory Support for the Management of Cardiogenic Shock.

Journal Article Cardiol Clin · November 2020 Cardiogenic shock (CS) is a complex condition with a high risk for morbidity and mortality. Mechanical circulatory support (MCS) devices were developed to support patients with CS in cases refractory to treatment with vasoactive medications. Current device ... Full text Link to item Cite

SCAI position statement on the performance of percutaneous coronary intervention in ambulatory surgical centers.

Journal Article Catheter Cardiovasc Interv · October 1, 2020 The Centers for Medicare & Medicaid Services (CMS) began reimbursement for percutaneous coronary intervention (PCI) performed in ambulatory surgical centers (ASC) in January 2020. The ability to perform PCI in an ASC has been made possible due to the outco ... Full text Link to item Cite

Trial Design Principles for Patients at High Bleeding Risk Undergoing PCI: JACC Scientific Expert Panel.

Journal Article J Am Coll Cardiol · September 22, 2020 Investigating the balance of risk for thrombotic and bleeding events after percutaneous coronary intervention (PCI) is especially relevant for patients at high bleeding risk (HBR). The Academic Research Consortium for HBR recently proposed a consensus defi ... Full text Link to item Cite

Management of Acute Myocardial Infarction During the COVID-19 Pandemic: A Position Statement From the Society for Cardiovascular Angiography and Interventions (SCAI), the American College of Cardiology (ACC), and the American College of Emergency Physicians (ACEP).

Journal Article J Am Coll Cardiol · September 15, 2020 The worldwide pandemic caused by the novel acute respiratory syndrome coronavirus 2 has resulted in a new and lethal disease termed coronavirus disease-2019 (COVID-19). Although there is an association between cardiovascular disease and COVID-19, the major ... Full text Link to item Cite

Multimodality Imaging in Evaluation of Cardiovascular Complications in Patients With COVID-19: JACC Scientific Expert Panel.

Journal Article J Am Coll Cardiol · September 15, 2020 Standard evaluation and management of the patient with suspected or proven cardiovascular complications of coronavirus disease-2019 (COVID-19), the disease caused by severe acute respiratory syndrome related-coronavirus-2 (SARS-CoV-2), is challenging. Rout ... Full text Link to item Cite

Splanchnic Nerve Block for Chronic Heart Failure.

Journal Article JACC Heart Fail · September 2020 OBJECTIVES: We hypothesized that splanchnic nerve blockade (SNB) would attenuate increased exercise-induced cardiac filling pressures in patients with chronic HF. BACKGROUND: Chronic heart failure (HF) is characterized by limited exercise capacity driven i ... Full text Link to item Cite

Percutaneous coronary intervention or coronary artery bypass graft surgery for left main coronary artery disease: A meta-analysis of randomized trials.

Journal Article Am Heart J · September 2020 We aimed to investigate long-term (≥5 years) outcomes of percutaneous coronary intervention (PCI) versus coronary artery bypass grafting (CABG) for left main coronary artery disease (LMCAD) using a meta-analysis from updated published randomized trials. Ou ... Full text Link to item Cite

A systematic review of randomized trials comparing double versus triple antithrombotic therapy in patients with atrial fibrillation undergoing percutaneous coronary intervention.

Journal Article Catheter Cardiovasc Interv · August 2020 BACKGROUND: Prior randomized controlled trials (RCT) evaluating the optimal antithrombotic therapies for patients with atrial fibrillation (AF) undergoing percutaneous coronary intervention (PCI) have not been powered to evaluate ischemic outcomes. We comp ... Full text Link to item Cite

Management of acute myocardial infarction during the COVID-19 pandemic: A Consensus Statement from the Society for Cardiovascular Angiography and Interventions (SCAI), the American College of Cardiology (ACC), and the American College of Emergency Physicians (ACEP).

Journal Article Catheter Cardiovasc Interv · August 2020 The worldwide pandemic caused by the novel acute respiratory syndrome coronavirus 2 has resulted in a new and lethal disease termed coronavirus disease 2019 (COVID-19). Although there is an association between cardiovascular disease and COVID-19, the major ... Full text Link to item Cite

The State of Percutaneous Intervention in Stable Coronary Artery Disease.

Journal Article Curr Atheroscler Rep · July 15, 2020 PURPOSE OF REVIEW: This review examines trials of percutaneous coronary intervention (PCI) compared with optimal medical therapy (OMT) in order to inform clinical decision-making regarding the role of PCI in stable ischemic heart disease (SIHD). RECENT FIN ... Full text Link to item Cite

Performance of Hospitals When Assessing Disease-Based Mortality Compared With Procedural Mortality for Patients With Acute Myocardial Infarction.

Journal Article JAMA Cardiol · July 1, 2020 IMPORTANCE: Quality of percutaneous coronary intervention (PCI) is commonly assessed by risk-adjusted mortality. However, this metric may result in procedural risk aversion, especially for high-risk patients. OBJECTIVE: To determine correlation and reclass ... Full text Link to item Cite

Coronary revascularization and circulatory support strategies in patients with myocardial infarction, multi-vessel coronary artery disease, and cardiogenic shock: Insights from an international survey.

Journal Article Am Heart J · July 2020 UNLABELLED: Cardiogenic shock (CS) complicating acute myocardial infarction (MI) is associated with high mortality. In the absence of data to support coronary revascularization beyond the infarct artery and selection of circulatory support devices or medic ... Full text Link to item Cite

A reduced transferrin saturation is independently associated with excess morbidity and mortality in older adults with heart failure and incident anemia.

Journal Article Int J Cardiol · June 15, 2020 BACKGROUND: Low transferrin saturation (TSAT) or reduced serum ferritin level are suggestive of iron deficiency but the relationship between iron parameters and outcomes has not been systematically evaluated in older adults with heart failure (HF) and anem ... Full text Link to item Cite

Prasugrel use and clinical outcomes by age among patients undergoing PCI for acute coronary syndrome: from the PROMETHEUS study.

Journal Article Clin Res Cardiol · June 2020 BACKGROUND: Prasugrel is a potent thienopyridine that may be preferentially used in younger patients with lower bleeding risk. OBJECTIVE: We compared prasugrel use and outcomes by age from the PROMETHEUS study. We also assessed age-related trends in treatm ... Full text Link to item Cite

Radial versus femoral access for percutaneous coronary intervention in patients with ST-segment elevation myocardial infarction: Trial sequential analysis.

Journal Article Am Heart J · June 2020 BACKGROUND: Randomized controlled trials (RCTs) have yielded conflicting results about the impact of transradial access (TRA) versus transfemoral access (TFA) in patients with ST-segment elevation myocardial infarction (STEMI). METHODS: We performed a tria ... Full text Link to item Cite

Differential Use and Impact of Bleeding Avoidance Strategies on Percutaneous Coronary Intervention-Related Bleeding Stratified by Predicted Risk.

Journal Article Circ Cardiovasc Interv · June 2020 BACKGROUND: Procedural anticoagulation with bivalirudin (BIV), trans-radial intervention (TRI), and use of a vascular closure device (VCD) are thought to mitigate percutaneous coronary intervention (PCI)-related bleeding. We compared the impact of these bl ... Full text Link to item Cite

Cardiac remodeling after large ST-elevation myocardial infarction in the current therapeutic era.

Journal Article Am Heart J · May 2020 BACKGROUND: The evolution and clinical impact of cardiac remodeling after large ST-elevation myocardial infarction (STEMI) is not well delineated in the current therapeutic era. METHODS: The PRESERVATION I trial longitudinally assessed cardiac structure an ... Full text Link to item Cite

Outcomes of Cardiac Catheterization in Patients With Atrial Fibrillation on Anticoagulation in Contemporary in Practice: An Analysis of the ORBIT II Registry.

Journal Article Circ Cardiovasc Interv · May 2020 BACKGROUND: Patients with atrial fibrillation on oral anticoagulation (OAC) undergoing cardiac catheterization face risks for embolic and bleeding events, yet information on strategies to mitigate these risks in contemporary practice is lacking. METHODS: W ... Full text Link to item Cite

Technical consideration in acute myocardial infarction with cardiogenic shock: A review of antithrombotic and PCI therapies.

Journal Article Catheter Cardiovasc Interv · April 1, 2020 In this review, we report a contemporary appraisal of the available evidence focusing on adjunctive antithrombotic therapy and technical aspects of percutaneous coronary interventions (PCI) in patients with acute myocardial infarction and cardiogenic shock ... Full text Link to item Cite

Global Approach to High Bleeding Risk Patients With Polymer-Free Drug-Coated Coronary Stents: The LF II Study.

Journal Article Circ Cardiovasc Interv · April 2020 BACKGROUND: High bleeding risk (HBR) patients undergoing percutaneous coronary intervention have been widely excluded from randomized device registration trials. The LF study (LEADERS FREE) reported superior outcomes of HBR patients receiving 30-day dual a ... Full text Link to item Cite

Complex regional pain syndrome: A rare but potentially disabling complication of transradial cardiac catheterization.

Journal Article Catheter Cardiovasc Interv · April 1, 2020 BACKGROUND: Chronic Regional Pain Syndrome (CRPS) is a rare complication following transradial cardiac catheterization. AIMS: To discuss the clinical features, pathophysiology, diagnosis and management of CRPS. METHODS: Literature review performed. RESULTS ... Full text Link to item Cite

Improving Care Pathways for Acute Coronary Syndrome: Patients Undergoing Percutaneous Coronary Intervention.

Journal Article Am J Cardiol · February 1, 2020 Acute coronary syndrome (ACS) admissions are common and costly. The association between comprehensive ACS care pathways, outcomes, and costs are lacking. From 434,172 low-risk, uncomplicated ACS patients eligible for early discharge (STEMI 35%, UA/NSTEMI 6 ... Full text Link to item Cite

SCAI expert consensus statement update on best practices for transradial angiography and intervention.

Journal Article Catheter Cardiovasc Interv · February 2020 Transradial angiography and intervention continues to become increasingly common as an access site for coronary procedures. Since the first "Best Practices" paper in 2013, ongoing trials have shed further light onto the safest and most efficient methods to ... Full text Link to item Cite

Trends in Usage and Clinical Outcomes of Coronary Atherectomy: A Report From the National Cardiovascular Data Registry CathPCI Registry.

Journal Article Circ Cardiovasc Interv · February 2020 BACKGROUND: Adjunctive coronary atherectomy (CA) can be utilized in treating severely calcified coronary lesions; however, the temporal trends, patient selection, and variation in use of CA have not been well described. We sought to assess the trends in us ... Full text Link to item Cite

Stent-Only Versus Adjunctive Balloon Angioplasty Approach for Saphenous Vein Graft Percutaneous Coronary Intervention: Insights From DIVA Trial.

Journal Article Circ Cardiovasc Interv · February 2020 BACKGROUND: Direct stenting without pre-dilation or post-dilation has been advocated for saphenous vein graft percutaneous coronary intervention to decrease the incidence of distal embolization, periprocedural myocardial infarction, and target lesion revas ... Full text Link to item Cite

The Evolving Landscape of Impella Use in the United States Among Patients Undergoing Percutaneous Coronary Intervention With Mechanical Circulatory Support.

Journal Article Circulation · January 28, 2020 BACKGROUND: Impella was approved for mechanical circulatory support (MCS) in 2008, but large-scale, real-world data on its use are lacking. Our objective was to describe trends and variations in Impella use, clinical outcomes, and costs across US hospitals ... Full text Link to item Cite

Radial Access for Peripheral Interventions.

Journal Article Interv Cardiol Clin · January 2020 Peripheral vascular intervention (PVI) improves quality of life and reduces major adverse limb events in patients with peripheral arterial disease. PVI is commonly performed via the femoral artery, and the most common adverse periprocedural event is a vasc ... Full text Link to item Cite

Reduced radiation exposure in the cardiac catheterization laboratory with a novel vertical radiation shield.

Journal Article Catheter Cardiovasc Interv · January 2020 OBJECTIVES: Investigation of novel vertical radiation shield (VRS) in reducing operator radiation exposure. BACKGROUND: Radiation exposure to the operator remains an occupational health hazard in the cardiac catheterization laboratory (CCL). METHODS: A man ... Full text Link to item Cite

Incidence, Temporal Trends, and Associated Outcomes of Vascular and Bleeding Complications in Patients Undergoing Transfemoral Transcatheter Aortic Valve Replacement: Insights From the Society of Thoracic Surgeons/American College of Cardiology Transcatheter Valve Therapies Registry.

Journal Article Circ Cardiovasc Interv · January 2020 BACKGROUND: Vascular and bleeding complications were commonly reported in transcatheter aortic valve replacement clinical trials. Little is known about complication rates in contemporary US clinical practice or clinical outcomes associated with these compl ... Full text Link to item Cite

Safety and efficacy of antiplatelet regimens after percutaneous coronary intervention using drug eluting stents: A network meta-analysis of randomized controlled trials.

Journal Article Prog Cardiovasc Dis · 2020 AIMS: We aimed to determine the efficacy and safety of different anti-platelet regimens after percutaneous coronary intervention (PCI) with drug eluting stent (DES) implantation using a network meta-analysis of randomized controlled trials (RCTs). METHODS: ... Full text Link to item Cite

Design and rationale of the North Indian ST-Segment Elevation Myocardial Infarction Registry: A prospective cohort study.

Journal Article Clin Cardiol · December 2019 ST-segment elevation myocardial infarction (STEMI) is associated with increased mortality and morbidity. Although remarkable progress has been made in the management of STEMI in high-income countries, contemporary data to evaluate processes and outcomes of ... Full text Link to item Cite

Opportunities for enhancing the care of older patients with ST-elevation myocardial infarction presenting for primary percutaneous coronary intervention: Rationale and design of the SAFE-STEMI for Seniors trial.

Journal Article Am Heart J · December 2019 Advanced age is directly related to worse outcomes following ST-elevation myocardial infarction (STEMI) and higher complication rates from antithrombotic therapies and primary percutaneous coronary intervention (PCI). Often excluded from clinical trials, s ... Full text Link to item Cite

Claims-based cardiovascular outcome identification for clinical research: Results from 7 large randomized cardiovascular clinical trials.

Journal Article Am Heart J · December 2019 BACKGROUND: Medicare insurance claims may provide an efficient means to ascertain follow-up of older participants in clinical research. We sought to determine the accuracy and completeness of claims- versus site-based follow-up with clinical event committe ... Full text Link to item Cite

Same-day discharge among patients undergoing elective PCI: Insights from the VA CART Program.

Journal Article Am Heart J · December 2019 BACKGROUND: Available data suggest that same-day discharge (SDD) after elective percutaneous coronary intervention (PCI) is safe in select patients. Yet, little is known about contemporary adoption rates, safety, and costs in a universal health care system ... Full text Link to item Cite

Best Practices for the Prevention of Radial Artery Occlusion After Transradial Diagnostic Angiography and Intervention: An International Consensus Paper.

Journal Article JACC Cardiovasc Interv · November 25, 2019 Transradial access (TRA) is increasingly used worldwide for percutaneous interventional procedures and associated with lower bleeding and vascular complications than transfemoral artery access. Radial artery occlusion (RAO) is the most frequent post-proced ... Full text Link to item Cite

Stability After Initial Decline in Coronary Revascularization Rates in the United States.

Journal Article Ann Thorac Surg · November 2019 BACKGROUND: It remains uncertain how advances in revascularization techniques, availability of new evidence, and updated guidelines have influenced the annual rates of coronary revascularization in the United States. METHODS: We used the Nationwide Inpatie ... Full text Link to item Cite

A Meta-Analysis of Aspirin for the Primary Prevention of Cardiovascular Diseases in the Context of Contemporary Preventive Strategies.

Journal Article Am J Med · November 2019 BACKGROUND: The role of aspirin for primary prevention of cardiovascular diseases remains controversial, particularly in the context of contemporary aggressive preventive strategies. METHODS: Relevant randomized clinical trials were included, and risk rati ... Full text Link to item Cite

Complete Revascularization with Multivessel PCI for Myocardial Infarction.

Journal Article N Engl J Med · October 10, 2019 BACKGROUND: In patients with ST-segment elevation myocardial infarction (STEMI), percutaneous coronary intervention (PCI) of the culprit lesion reduces the risk of cardiovascular death or myocardial infarction. Whether PCI of nonculprit lesions further red ... Full text Link to item Cite

Incident anaemia in older adults with heart failure: rate, aetiology, and association with outcomes.

Journal Article Eur Heart J Qual Care Clin Outcomes · October 1, 2019 AIMS: Limited data exist on the epidemiology, evaluation, and prognosis of otherwise unexplained anaemia of the elderly in heart failure (HF). Thus, we aimed to determine the incidence of anaemia, to characterize diagnostic testing patterns for potentially ... Full text Link to item Cite

The OPTIMIZE randomized trial to assess safety and efficacy of the Svelte IDS and RX Sirolimus-eluting coronary stent Systems for the Treatment of atherosclerotic lesions: Trial design and rationale.

Journal Article Am Heart J · October 2019 Coronary stenting without angioplasty pretreatment (direct stenting) may simplify procedures in appropriate lesions. Direct stenting is facilitated by smaller profile coronary stent platforms. The present study was designed for regulatory approval of a nov ... Full text Link to item Cite

Ad hoc percutaneous coronary intervention in patients with stable coronary artery disease: A report from the National Cardiovascular Data Registry CathPCI Registry.

Journal Article Am Heart J · October 2019 UNLABELLED: Percutaneous coronary intervention (PCI) may be performed in the same procedure as diagnostic coronary angiography (ad hoc PCI). This study aimed to evaluate current rates of ad hoc PCI use and associated risks of adverse outcomes in patients w ... Full text Link to item Cite

Association of Hyperglycemia and Final TIMI Flow with One-Year Mortality of Patients with Acute ST-Segment Elevation Myocardial Infarction Undergoing Primary PCI.

Journal Article Int J Angiol · September 2019 The association of hyperglycemia at admission and final thrombolysis in myocardial infarction (TIMI) flow with 1-year mortality of patient with acute ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention ( ... Full text Link to item Cite

Cath Lab Robotics: Paradigm Change in Interventional Cardiology?

Journal Article Curr Cardiol Rep · August 31, 2019 PURPOSE OF REVIEW: To review the contemporary evidence for robotic-assisted percutaneous coronary and vascular interventions, discussing its current capabilities, limitations, and potential future applications. RECENT FINDINGS: Robotic-assisted cardiovascu ... Full text Link to item Cite

Defining high bleeding risk in patients undergoing percutaneous coronary intervention: a consensus document from the Academic Research Consortium for High Bleeding Risk.

Journal Article Eur Heart J · August 14, 2019 Identification and management of patients at high bleeding risk undergoing percutaneous coronary intervention are of major importance, but a lack of standardization in defining this population limits trial design, data interpretation, and clinical decision ... Full text Link to item Cite

The Predictors of Post-Procedural Arm Pain after Transradial Approach in 1706 Patients Underwent Transradial Catheterization.

Journal Article Cardiovasc Revasc Med · August 2019 BACKGROUND: Although patients prefer radial over femoral approach, some develop post-procedural arm pain after transradial procedures. This complication has been poorly defined in prior studies. We evaluated the extent of non-ischemic arm pain after transr ... Full text Link to item Cite

Bivalirudin with a post-procedure infusion versus heparin monotherapy for the prevention of stent thrombosis.

Journal Article Catheter Cardiovasc Interv · August 1, 2019 OBJECTIVES: To evaluate the efficacy of post-primary percutaneous coronary intervention (PCI) bivalirudin infusion (at full PCI dose) to prevent stent thrombosis (ST) compared with heparin monotherapy. BACKGROUND: Early randomized controlled trials (RCTs) ... Full text Link to item Cite

Association of Coronary Anatomical Complexity With Clinical Outcomes After Percutaneous or Surgical Revascularization in the Veterans Affairs Clinical Assessment Reporting and Tracking Program.

Journal Article JAMA Cardiol · August 1, 2019 IMPORTANCE: Anatomical scoring systems for coronary artery disease, such as the SYNTAX (Synergy Between Percutaneous Coronary Intervention [PCI] With Taxus and Cardiac Surgery) score, are well established tools for understanding patient risk. However, they ... Full text Link to item Cite

Examining the Operator Learning Curve for Percutaneous Coronary Intervention of Chronic Total Occlusions.

Journal Article Circ Cardiovasc Interv · August 2019 BACKGROUND: Advances in chronic total occlusion percutaneous coronary intervention (CTO PCI) techniques have led to increased procedural success rates among operators. While utilization of CTO PCI has disseminated widely, the learning curve for new operato ... Full text Link to item Cite

Defining High Bleeding Risk in Patients Undergoing Percutaneous Coronary Intervention.

Journal Article Circulation · July 16, 2019 Identification and management of patients at high bleeding risk undergoing percutaneous coronary intervention are of major importance, but a lack of standardization in defining this population limits trial design, data interpretation, and clinical decision ... Full text Link to item Cite

Use of prasugrel and clinical outcomes in African-American patients treated with percutaneous coronary intervention for acute coronary syndromes.

Journal Article Catheter Cardiovasc Interv · July 1, 2019 OBJECTIVE: To investigate the use of prasugrel after percutaneous coronary intervention (PCI) in African American (AA) patients presenting with acute coronary syndrome (ACS). BACKGROUND: AA patients are at higher risk for adverse cardiovascular outcomes af ... Full text Link to item Cite

Associations between use of prasugrel vs clopidogrel and outcomes by type of acute coronary syndrome: an analysis from the PROMETHEUS registry.

Journal Article J Thromb Thrombolysis · July 2019 We sought to investigate the utilization of prasugrel and its association with outcomes relative to clopidogrel in three typical subgroups of ACS in a real-world setting. Prasugrel is superior to clopidogrel for reducing risk of ischemic events in acute co ... Full text Link to item Cite

Risk of obstructive coronary artery disease and major adverse cardiac events in patients with noncoronary atherosclerosis: Insights from the Veterans Affairs Clinical Assessment, Reporting, and Tracking (CART) Program.

Journal Article Am Heart J · July 2019 UNLABELLED: We sought to determine the risk of obstructive coronary artery disease (oCAD) associated with noncoronary atherosclerosis (cerebrovascular disease [CVD] or peripheral arterial disease [PAD]) and major adverse cardiac events following percutaneo ... Full text Link to item Cite

Contemporary transradial access practices: Results of the second international survey.

Journal Article Catheter Cardiovasc Interv · June 1, 2019 OBJECTIVES: To gain insight into current practice of transradial angiography and intervention in the United States and around the world. BACKGROUND: Transradial access (TRA) has grown worldwide. In a prior survey, there was significant practice variation a ... Full text Link to item Cite

Reply.

Journal Article Gastroenterology · June 2019 Full text Link to item Cite

Comparison of Rates of Bleeding and Vascular Complications Before, During, and After Trial Enrollment in the SAFE-PCI Trial for Women.

Journal Article Circ Cardiovasc Interv · May 2019 BACKGROUND: SAFE-PCI for Women (Study of Access Site for Enhancement of PCI for Women), a randomized controlled trial comparing radial and femoral access in women undergoing cardiac catheterization or percutaneous coronary intervention (PCI), was terminate ... Full text Link to item Cite

Age, STEMI, and Cardiogenic Shock: Never Too Old for PCI?

Journal Article J Am Coll Cardiol · April 23, 2019 Full text Link to item Cite

Safety and efficacy of radial versus femoral access for rotational Atherectomy: A systematic review and meta-analysis.

Journal Article Cardiovasc Revasc Med · March 2019 INTRODUCTION: Over the recent years, there has been increased interest in the use of transradial (TR) access for percutaneous coronary intervention (PCI), including rotational atherectomy (RA). However, a large proportion of operators seem to be reluctant ... Full text Link to item Cite

Policing or Learning?

Journal Article Circ Cardiovasc Qual Outcomes · March 2019 Full text Link to item Cite

Incidence and prognostic impact of post discharge bleeding post acute coronary syndrome within an outpatient setting: a systematic review.

Journal Article BMJ Open · February 20, 2019 OBJECTIVE: The primary objective was to determine the incidence of bleeding events post acute coronary syndrome (ACS) following hospital discharge. The secondary objective was to determine the prognostic impact of bleeding on mortality, major adverse cardi ... Full text Link to item Cite

The prevalence, predictors and outcomes of guideline-directed medical therapy in patients with acute myocardial infarction undergoing PCI, an analysis from the PROMETHEUS registry.

Journal Article Catheter Cardiovasc Interv · February 15, 2019 OBJECTIVES: To investigate the prevalence, predictors and associations between guideline-directed medical therapy (GDMT) and clinical outcomes in acute myocardial infarction (AMI) patients undergoing percutaneous coronary intervention (PCI) from eight acad ... Full text Link to item Cite

Safety and efficacy of switching from unfractionated heparin to bivalirudin during primary percutaneous coronary intervention.

Journal Article Catheter Cardiovasc Interv · February 1, 2019 OBJECTIVES: To evaluate the safety and efficacy of switching to bivalirudin during primary percutaneous coronary intervention (PCI) for patients who received preprocedure unfractionated heparin (UFH). BACKGROUND: Current guidelines favor bivalirudin for pr ... Full text Link to item Cite

Association of Physician Variation in Use of Manual Aspiration Thrombectomy With Outcomes Following Primary Percutaneous Coronary Intervention for ST-Elevation Myocardial Infarction: The National Cardiovascular Data Registry CathPCI Registry.

Journal Article JAMA Cardiol · February 1, 2019 IMPORTANCE: Following negative randomized clinical trials, US guidelines downgraded support for routine manual aspiration thrombectomy (AT) during primary percutaneous coronary intervention (pPCI) for ST-segment elevation myocardial infarction (STEMI). How ... Full text Link to item Cite

Supporting the Crucible of Peer Review.

Journal Article Circ Cardiovasc Interv · February 2019 Full text Link to item Cite

Medical Misinformation: Vet the Message!

Journal Article Circulation · January 28, 2019 Full text Link to item Cite

Relationship Between Operator Volume and Long-Term Outcomes After Percutaneous Coronary Intervention.

Journal Article Circulation · January 22, 2019 BACKGROUND: Although many studies show an inverse association between operator procedural volume and short-term adverse outcomes after percutaneous coronary intervention (PCI), the association between procedural volume and longer-term outcomes is unknown. ... Full text Link to item Cite

Use of prasugrel vs clopidogrel and outcomes in patients with and without diabetes mellitus presenting with acute coronary syndrome undergoing percutaneous coronary intervention.

Journal Article Int J Cardiol · January 15, 2019 BACKGROUND: Clinical trial data studies suggest superiority of prasugrel over clopidogrel in patients with diabetes. However, the use, safety and efficacy profile of prasugrel in unselected diabetic patients presenting with acute coronary syndromes (ACS) r ... Full text Link to item Cite

Advances in Antiplatelet and Anticoagulant Therapies for NSTE-ACS.

Journal Article Curr Cardiol Rep · January 12, 2019 The treatment of patients requiring anticoagulation who develop acute coronary syndrome (ACS) and/or require percutaneous coronary intervention (PCI) must balance the reduction in major adverse cardiovascular events, stroke, and major bleeding. The develop ... Full text Link to item Cite

Relation of Length of Stay to Unplanned Readmissions for Patients Who Undergo Elective Percutaneous Coronary Intervention.

Journal Article Am J Cardiol · January 1, 2019 The cost of inpatient percutaneous coronary interventions (PCI) procedure is related to length of stay (LOS). It is unknown, how LOS may be associated with readmission rates and costs of index PCI and readmissions in elective PCI. This study aims to evalua ... Full text Link to item Cite

Cardiac allograft vasculopathy: A review.

Journal Article Catheter Cardiovasc Interv · December 1, 2018 Cardiac allograft vasculopathy (CAV) is a complex disease that remains a significant cause of morbidity and mortality after orthotopic heart transplantation (OHT). Originating as a result of inflammatory response, the development and progression of CAV is ... Full text Link to item Cite

A quality framework for the role of invasive, non-interventional cardiologists in the present-day cardiac catheterization laboratory: A multidisciplinary SCAI/HFSA expert consensus statement.

Journal Article Catheter Cardiovasc Interv · December 1, 2018 The present-day cardiac catheterization laboratory (CCL) is home to varied practitioners who perform both diagnostic, interventional, and complex invasive procedures. Invasive, non-interventional cardiologists are performing a significant proportion of the ... Full text Link to item Cite

Different Spasmolytic Regimens (Nitroglycerin vs Verapamil) and the Incidence of Radial Artery Occlusion After Transradial Catheterization.

Journal Article J Invasive Cardiol · December 2018 OBJECTIVE: This study evaluated whether use of different spasmolytic regimens (nitroglycerin or verapamil) administered soon after sheath insertion affects postprocedure radial artery occlusion (RAO) in patients who underwent transradial catheterization. M ... Link to item Cite

Association of Anemia With Outcomes Among ST-Segment-Elevation Myocardial Infarction Patients Receiving Primary Percutaneous Coronary Intervention.

Journal Article Circ Cardiovasc Interv · December 2018 BACKGROUND: Anemia may confer a poor prognosis among patients with the acute coronary syndrome. However, few data exist on the association of anemia with in-hospital outcomes, including bleeding, among ST-segment-elevation myocardial infarction patients re ... Full text Link to item Cite

Preventing Acute Radial Artery Occlusion: A Battle on Multiple Fronts.

Journal Article JACC Cardiovasc Interv · November 26, 2018 Full text Link to item Cite

Predictors and Outcomes of Staged Versus One-Time Multivessel Revascularization in Multivessel Coronary Artery Disease: Insights From the VA CART Program.

Journal Article JACC Cardiovasc Interv · November 26, 2018 OBJECTIVES: The aim of this study was to determine predictors and outcomes associated with staged percutaneous coronary intervention (PCI) versus one-time multivessel revascularization (OTMVR) in patients with multivessel coronary artery disease. BACKGROUN ... Full text Link to item Cite

Heparin use for diagnostic cardiac catheterization with a radial artery approach: An international survey of practice patterns.

Journal Article Catheter Cardiovasc Interv · November 1, 2018 OBJECTIVES: We aimed to describe global practice patterns of unfractionated heparin (UFH) use for diagnostic transradial cardiac catheterization. BACKGROUND: The use of the radial artery approach for cardiac catheterization is increasing globally. Limited ... Full text Link to item Cite

Impact of sheath size and hemostasis time on radial artery patency after transradial coronary angiography and intervention in Japanese and non-Japanese patients: A substudy from RAP and BEAT (Radial Artery Patency and Bleeding, Efficacy, Adverse evenT) randomized multicenter trial.

Journal Article Catheter Cardiovasc Interv · November 1, 2018 BACKGROUND: During transradial (TR) access, it remains unclear whether differences in baseline patients characteristics and hemostasis care impact the rate of radial artery occlusion (RAO). We sought to compare the rate of RAO after TR access with the 6 Fr ... Full text Link to item Cite

Association of Same-Day Discharge After Elective Percutaneous Coronary Intervention in the United States With Costs and Outcomes.

Journal Article JAMA Cardiol · November 1, 2018 IMPORTANCE: Same-day discharge (SDD) after elective percutaneous coronary intervention (PCI) is associated with lower costs and preferred by patients. However, to our knowledge, contemporary patterns of SDD after elective PCI with respect to the incidence, ... Full text Link to item Cite

Efficacy and Safety of Drug-Eluting Stents Optimized for Biocompatibility vs Bare-Metal Stents With a Single Month of Dual Antiplatelet Therapy: A Meta-analysis.

Journal Article JAMA Cardiol · November 1, 2018 IMPORTANCE: A significant number of patients receive bare-metal stents (BMSs) instead of drug-eluting stents (DESs) to shorten the duration of dual antiplatelet therapy (DAPT). Emerging evidence suggests that new-generation DESs, particularly those optimiz ... Full text Link to item Cite

Percutaneous or surgical access for transfemoral transcatheter aortic valve implantation.

Journal Article J Thorac Dis · November 2018 Transcatheter aortic valve implantation is an important therapeutic option for patients with symptomatic, severe aortic stenosis at increased risk for open surgical aortic valve replacement. Although a number of alternative vascular access sites have been ... Full text Link to item Cite

Thrombus Aspiration in Patients With High Thrombus Burden in the TOTAL Trial.

Journal Article J Am Coll Cardiol · October 2, 2018 BACKGROUND: Routine thrombus aspiration in patients undergoing primary percutaneous coronary intervention (PCI) for ST-segment elevation myocardial infarction (STEMI) does not improve clinical outcomes. However, there is remaining uncertainty about the pot ... Full text Link to item Cite

Length of stay following percutaneous coronary intervention: An expert consensus document update from the society for cardiovascular angiography and interventions.

Journal Article Catheter Cardiovasc Interv · October 1, 2018 Since the publication of the 2009 SCAI Expert Consensus Document on Length of Stay Following percutaneous coronary intervention (PCI), advances in vascular access techniques, stent technology, and antiplatelet pharmacology have facilitated changes in disch ... Full text Link to item Cite

Ultrasound-guided versus palpation-guided radial artery catheterization in adult population: A systematic review and meta-analysis of randomized controlled trials.

Journal Article Am Heart J · October 2018 BACKGROUND: The radial artery (RA) is routinely used for both hemodynamic monitoring and for cardiac catheterization. Although cannulation of the RA is usually undertaken through manual palpation, ultrasound (US)-guided access has been advocated as a mean ... Full text Link to item Cite

Novel method for radial sheath removal using manual pressure over hemostatic pad combined with ulnar compression.

Journal Article Catheter Cardiovasc Interv · August 1, 2018 OBJECTIVES: Study a novel method using manual pressure on a hemostatic pad and hemoband for ulnar compression as a potential alternative for radial sheath removal. BACKGROUND: The standard for transradial access site (TRA) sheath removal requires an inflat ... Full text Link to item Cite

Post-Traumatic Stress Disorder and Heart Failure in Men Within the Veteran Affairs Health System.

Journal Article Am J Cardiol · July 15, 2018 Patients with post-traumatic stress disorder (PTSD) are at risk of multiple co-morbidities and are more likely to develop incident heart failure with reduced ejection fraction (HFrEF). The relation of PTSD with clinical outcomes in HFrEF is not established ... Full text Link to item Cite

Relation Between Age and Unplanned Readmissions After Percutaneous Coronary Intervention (Findings from the Nationwide Readmission Database).

Journal Article Am J Cardiol · July 15, 2018 It is unclear how age affects rates and causes of unplanned early readmissions after percutaneous coronary intervention (PCI). We analyzed patients in the Nationwide Readmission Database in the United States from 2010 to 2014 and examined the impact of age ... Full text Link to item Cite

Robotic-assisted transradial diagnostic coronary angiography.

Journal Article Catheter Cardiovasc Interv · July 2018 Robotic percutaneous coronary interventions have recently been introduced in the cardiac catheterization laboratory. Robotics offers benefits of greater precision for stent placement and occupational hazard protection for operators and staff. First generat ... Full text Link to item Cite

Clinical trials evaluating red blood cell transfusion thresholds: An updated systematic review and with additional focus on patients with cardiovascular disease.

Journal Article Am Heart J · June 2018 BACKGROUND: Several new trials evaluating transfusion strategies in patients with cardiovascular disease have recently been published, increasing the number of enrolled patients by over 30%. The objective was to evaluate transfusion thresholds in patients ... Full text Link to item Cite

Drug-eluting stents versus bare-metal stents in saphenous vein grafts: a double-blind, randomised trial.

Journal Article Lancet · May 19, 2018 BACKGROUND: Few studies have examined the efficacy of drug-eluting stents (DES) for reducing aortocoronary saphenous vein bypass graft (SVG) failure compared with bare-metal stents (BMS) in patients undergoing stenting of de-novo SVG lesions. We assessed t ... Full text Link to item Cite

Burden of 30-Day Readmissions After Percutaneous Coronary Intervention in 833,344 Patients in the United States: Predictors, Causes, and Cost: Insights From the Nationwide Readmission Database.

Journal Article JACC Cardiovasc Interv · April 9, 2018 OBJECTIVES: This study aimed to examine the 30-day unplanned readmissions rate, predictors of readmission, causes of readmissions, and clinical impact of readmissions after percutaneous coronary intervention (PCI). BACKGROUND: Unplanned rehospitalizations ... Full text Link to item Cite

Routine Invasive Versus Selective Invasive Strategy in Elderly Patients Older Than 75 Years With Non-ST-Segment Elevation Acute Coronary Syndrome: A Systematic Review and Meta-Analysis.

Journal Article Mayo Clin Proc · April 2018 OBJECTIVE: To evaluate outcomes of routine invasive strategy (RIS) compared with selective invasive strategy (SIS) in elderly patients older than 75 years with non-ST-segment elevation acute coronary syndrome (NSTE-ACS). METHODS: We systematically searched ... Full text Link to item Cite

The Radial Artery for Percutaneous Coronary Procedures or Surgery?

Journal Article J Am Coll Cardiol · March 13, 2018 This article summarizes the current research on the benefits of using the transradial approach for percutaneous procedures and the radial artery as a conduit for coronary artery bypass surgery. Based on the available evidence, the authors provide recommend ... Full text Link to item Cite

Device Closure Versus Medical Therapy Alone for Patent Foramen Ovale in Patients With Cryptogenic Stroke: A Systematic Review and Meta-analysis.

Journal Article Ann Intern Med · March 6, 2018 BACKGROUND: The optimal strategy for preventing recurrent stroke in patients with cryptogenic stroke and patent foramen ovale (PFO) is unknown. PURPOSE: To compare transcatheter PFO closure with medical therapy alone for prevention of recurrent stroke in p ... Full text Link to item Cite

Anemia and coronary artery disease: pathophysiology, prognosis, and treatment.

Journal Article Coron Artery Dis · March 2018 The mechanisms, pathophysiology, and treatment of anemia in coronary artery disease (CAD) are complex. The hemodynamic changes found in the acute anemic state may contribute to progressive arterial wall and left ventricular hypertrophy if the anemic state ... Full text Link to item Cite

Influence of operator experience and PCI volume on transfemoral access techniques: A collaboration of international cardiovascular societies.

Journal Article Cardiovasc Revasc Med · March 2018 INTRODUCTION: Transfemoral access (TFA) is widely used for coronary angiography and percutaneous coronary intervention (PCI). The influence of operator age, gender, experience, and procedural volume on performance of femoral arterial access has not been st ... Full text Link to item Cite

OUTCOMES OF CARDIAC CATH/PCI IN PATIENTS WITH AF: INSIGHTS FROM THE ORBIT II REGISTRY

Conference Journal of the American College of Cardiology · March 2018 Full text Cite

Associations Between Complex PCI and Prasugrel or Clopidogrel Use in Patients With Acute Coronary Syndrome Who Undergo PCI: From the PROMETHEUS Study.

Journal Article Can J Cardiol · March 2018 BACKGROUND: Potent P2Y12 inhibitors might offer enhanced benefit against thrombotic events in complex percutaneous coronary intervention (PCI). We examined prasugrel use and outcomes according to PCI complexity, as well as analyzing treatment effects accor ... Full text Link to item Cite

Appropriateness and Outcomes of Percutaneous Coronary Intervention at Top-Ranked and Nonranked Hospitals in the United States.

Journal Article JACC Cardiovasc Interv · February 26, 2018 OBJECTIVES: This study sought to compare the appropriate use and outcomes of percutaneous coronary intervention (PCI) between top-ranked and nonranked hospitals. BACKGROUND: The U.S. News & World Report "Best Hospitals" rankings are an influential consumer ... Full text Link to item Cite

Incidence, procedural management, and clinical outcomes of coronary in-stent restenosis: Insights from the National VA CART Program.

Journal Article Catheter Cardiovasc Interv · February 15, 2018 BACKROUND: In-stent restenosis (ISR) remains a common clinical problem associated with significant morbidity. We sought to evaluate the temporal trends in incidence and procedural management of coronary restenosis as well as evaluate the association betwee ... Full text Link to item Cite

Anticoagulant Use Among Patients With End-Stage Renal Disease Undergoing Percutaneous Coronary Intervention: An Analysis From the National Cardiovascular Data Registry.

Journal Article Circ Cardiovasc Interv · February 2018 BACKGROUND: Patients with end-stage renal disease undergoing percutaneous coronary intervention (PCI) have largely been excluded from trials of antithrombotic therapies leaving little data to guide agent choice in this population. METHODS AND RESULTS: The ... Full text Link to item Cite

Lower Repeat Revascularization Rates Among Patients With Prior Coronary Artery Bypass Graft Surgery are Due to Lack of Adequate Target Vessels.

Journal Article J Invasive Cardiol · February 2018 BACKGROUND: Studies comparing percutaneous coronary intervention (PCI) and coronary artery bypass graft (CABG) surgery in patients with multivessel coronary artery disease (CAD) have shown lower repeat revascularization rates in patients who undergo CABG. ... Link to item Cite

Comparison of Radial Access, Guided Femoral Access, and Non-Guided Femoral Access Among Women Undergoing Percutaneous Coronary Intervention.

Journal Article The Journal of invasive cardiology · January 2018 ObjectivesThis study was conducted to determine the association between radial access, guided femoral access, and non-guided femoral access on postprocedural bleeding and vascular complications after percutaneous coronary intervention (PCI).Ba ... Cite

Two-year mortality of primary angioplasty for acute myocardial infarction during regular working hours versus off-hours.

Journal Article Cardiovasc Revasc Med · 2018 BACKGROUND: Studies with short-term follow-up found higher mortality in patients with STEMI who underwent primary PCI during off-hours as compared to regular working hours. We analyzed the interaction between one and two-year survival of patients with STEM ... Full text Link to item Cite

Thrombus pharmacotherapy

Chapter · January 1, 2018 Antithrombotic therapy plays a fundamental role in the treatment of arterial and venous thrombotic diseases and in percutaneous coronary intervention. The landscape of anticoagulant therapy for atrial fibrillation has changed significantly with the availab ... Full text Cite

Understanding operator stent choice in the catheterization laboratory using a pre-procedure survey: Opportunities for quality improvement.

Journal Article Cardiovasc Revasc Med · December 2017 OBJECTIVES: We sought to characterize how the perceived risk of early dual antiplatelet therapy (DAPT) discontinuation is incorporated into operator decision-making regarding stent choice, using a simple pre-procedure survey screening for clinical variable ... Full text Open Access Link to item Cite

Outcomes of Saphenous Vein Graft Intervention With and Without Embolic Protection Device: A Comprehensive Review and Meta-Analysis.

Journal Article Circ Cardiovasc Interv · December 2017 BACKGROUND: Current guidelines give a class I recommendation to use of embolic protection devices (EPD) for saphenous vein graft (SVG) intervention; however, studies have shown conflicting results. The objective of this meta-analysis is to compare all-caus ... Full text Link to item Cite

Variation in the Adoption of Transradial Access for ST-Segment Elevation Myocardial Infarction: Insights From the NCDR CathPCI Registry.

Journal Article JACC Cardiovasc Interv · November 27, 2017 OBJECTIVES: The study sought to define patient, operator, and institutional factors associated with transradial access (TRA) in ST-segment elevation myocardial infarction (STEMI) percutaneous coronary intervention (PCI), the variation in use across operato ... Full text Link to item Cite

Transfemoral Approach for Coronary Angiography and Intervention: A Collaboration of International Cardiovascular Societies.

Journal Article JACC Cardiovasc Interv · November 27, 2017 OBJECTIVES: The aim of this study was to examine the current practice and use of transfemoral approach (TFA) for coronary angiography and intervention. BACKGROUND: Wide variability exists in TFA techniques for coronary procedures. METHODS: The authors deve ... Full text Link to item Cite

Variation in practice and concordance with guideline criteria for length of stay after elective percutaneous coronary intervention.

Journal Article Catheter Cardiovasc Interv · November 1, 2017 BACKGROUND: Considerable variability remains as regards the appropriate and safe length of stay after elective PCI. We performed a survey of interventional cardiologists to identify current views on appropriate and safe length of stay after PCI. METHODS: W ... Full text Link to item Cite

Rationale and design of the Drug-Eluting Stents vs Bare-Metal Stents in Saphenous Vein Graft Angioplasty (DIVA) Trial.

Journal Article Clin Cardiol · November 2017 VA Cooperative Studies Program #571 (DIVA) was designed to evaluate the efficacy of drug-eluting stents (DES) for reducing aortocoronary saphenous vein bypass graft (SVG) failure when compared with bare-metal stents (BMS) in participants undergoing stentin ... Full text Link to item Cite

Orbital atherectomy for the treatment of severely calcified coronary lesions: evidence, technique, and best practices.

Journal Article Expert review of medical devices · November 2017 IntroductionThe presence of severe coronary artery calcification is associated with higher rates of angiographic complications during percutaneous coronary intervention (PCI), as well as higher major adverse cardiac events compared with non-calcif ... Full text Cite

Associations Between Chronic Kidney Disease and Outcomes With Use of Prasugrel Versus Clopidogrel in Patients With Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention: A Report From the PROMETHEUS Study.

Journal Article JACC Cardiovasc Interv · October 23, 2017 OBJECTIVES: This study sought to compare clinical outcomes in a contemporary acute coronary syndrome (ACS) percutaneous coronary intervention (PCI) cohort stratified by chronic kidney disease (CKD) status. BACKGROUND: Patients with CKD exhibit high risks f ... Full text Link to item Cite

Benefits and risks of P2Y12 inhibitor preloading in patients with acute coronary syndrome and stable angina.

Journal Article J Thromb Thrombolysis · October 2017 Treatment with P2Y12 inhibitors is an integral part of the standard of care for patients undergoing percutaneous coronary intervention. However, the most appropriate timing for P2Y12 inhibitor administration remains unclear, and the value of "preloading" w ... Full text Link to item Cite

Perioperative Management of Dual-Antiplatelet Therapy in Patients With New-Generation Drug-Eluting Metallic Stents and Bioresorbable Vascular Scaffolds Undergoing Elective Noncardiac Surgery.

Journal Article J Cardiothorac Vasc Anesth · October 2017 Dual-antiplatelet therapy (DAPT) is considered mandatory after new-generation drug-eluting coronary stent implantation to reduce ischemic complications such as stent thrombosis, but the need for DAPT makes the timing of elective surgery difficult. Interrup ... Full text Link to item Cite

Comparative Outcomes After Percutaneous Coronary Intervention Among Black and White Patients Treated at US Veterans Affairs Hospitals.

Journal Article JAMA Cardiol · September 1, 2017 IMPORTANCE: Current comparative outcomes among black and white patients treated with percutaneous coronary intervention (PCI) in the Veterans Affairs (VA) health system are not known. OBJECTIVE: To compare outcomes between black and white patients undergoi ... Full text Link to item Cite

Selection of Stent Type in Patients With Atrial Fibrillation Presenting With Acute Myocardial Infarction: An Analysis From the ACTION (Acute Coronary Treatment and Intervention Outcomes Network) Registry-Get With the Guidelines.

Journal Article J Am Heart Assoc · August 21, 2017 BACKGROUND: Patients receiving oral anticoagulation in addition to dual-antiplatelet therapy are known to be at high risk for bleeding events; thus, the selection of a drug-eluting stent (DES) versus a bare metal stent (BMS) can have important implications ... Full text Link to item Cite

Comparison of a new slender 6 Fr sheath with a standard 5 Fr sheath for transradial coronary angiography and intervention: RAP and BEAT (Radial Artery Patency and Bleeding, Efficacy, Adverse evenT), a randomised multicentre trial.

Journal Article EuroIntervention · August 4, 2017 AIMS: The 6 Fr Glidesheath Slender (GSS6Fr) is a recently developed thin-walled radial sheath with an outer diameter (OD) that is smaller than the OD of standard 6 Fr sheaths. The purpose of this trial was to clarify whether the use of this new slender she ... Full text Link to item Cite

Effect of post-primary percutaneous coronary intervention bivalirudin infusion on net adverse clinical events and mortality: A comprehensive pairwise and network meta-analysis of randomized controlled trials.

Journal Article Catheter Cardiovasc Interv · August 1, 2017 OBJECTIVE: To compare the efficacies of various post-percutaneous coronary intervenetion (PCI) bivalirudin doses on net adverse clinical events (NACEs) and mortality. BACKGROUND: In primary PCI, lower risk of bleeding with bivalirudin (vs. unfractionated h ... Full text Link to item Cite

Morbidity and Mortality Conference for Percutaneous Coronary Intervention.

Journal Article Circ Cardiovasc Qual Outcomes · August 2017 BACKGROUND: Morbidity and mortality conference is a common educational and quality improvement activity performed in cardiac catheterization laboratories, but best practices for case selection and for maximizing the effectiveness of peer review have not be ... Full text Link to item Cite

Revascularization Strategies and Outcomes in Elderly Patients With Multivessel Coronary Disease.

Journal Article Ann Thorac Surg · July 2017 BACKGROUND: Balancing risks and benefits of revascularization in elderly patients with multivessel coronary artery disease (CAD) is challenging. The appropriate revascularization strategy for elderly patients with multivessel CAD is unclear. METHODS: We us ... Full text Link to item Cite

Outcomes of PCI in Relation to Procedural Characteristics and Operator Volumes in the United States.

Journal Article J Am Coll Cardiol · June 20, 2017 BACKGROUND: Professional guidelines have reduced the recommended minimum number to an average of 50 percutaneous coronary intervention (PCI) procedures performed annually by each operator. Operator volume patterns and associated outcomes since this change ... Full text Link to item Cite

Meta-Analysis of Randomized Controlled Trials of Percutaneous Coronary Intervention With Drug-Eluting Stents Versus Coronary Artery Bypass Grafting in Left Main Coronary Artery Disease.

Journal Article Am J Cardiol · June 15, 2017 Few randomized controlled trials (RCTs) and observational studies had shown acceptable short-term efficacy and safety of percutaneous coronary intervention (PCI) with drug-eluting stents (DES) compared with coronary artery bypass grafting (CABG) in selecte ... Full text Link to item Cite

Outcomes in Patients Undergoing Primary Percutaneous Coronary Intervention for ST-Segment Elevation Myocardial Infarction Via Radial Access Anticoagulated With Bivalirudin Versus Heparin: A Report From the National Cardiovascular Data Registry.

Journal Article JACC Cardiovasc Interv · June 12, 2017 OBJECTIVES: The aim of this study was to compare bivalirudin with heparin as anticoagulant agents in patients with ST-segment elevation myocardial infarction treated with radial primary percutaneous coronary intervention (PCI). BACKGROUND: Recent studies i ... Full text Link to item Cite

Use of prasugrel vs clopidogrel and outcomes in patients with acute coronary syndrome undergoing percutaneous coronary intervention in contemporary clinical practice: Results from the PROMETHEUS study.

Journal Article Am Heart J · June 2017 BACKGROUND AND OBJECTIVES: We sought to determine the frequency of use and association between prasugrel and outcomes in acute coronary syndrome patients undergoing percutaneous coronary intervention (PCI) in clinical practice. METHODS: PROMETHEUS was a mu ... Full text Link to item Cite

Transcatheter Aortic Valve Replacement Versus Surgical Valve Replacement in Low-Intermediate Surgical Risk Patients: A Systematic Review and Meta-Analysis.

Journal Article J Invasive Cardiol · June 2017 BACKGROUND: Transcatheter aortic valve replacement (TAVR) is a viable alternative to surgical aortic valve replacement (SAVR) in patients with severe aortic stenosis (SAS) who are at high risk for surgery. We sought to evaluate the outcomes of TAVR vs SAVR ... Link to item Cite

Putting Prognosis Into Perspective.

Journal Article Circ Cardiovasc Qual Outcomes · June 2017 Full text Link to item Cite

Acute Kidney Injury After Radial or Femoral Access for Invasive Acute Coronary Syndrome Management: AKI-MATRIX

Journal Article Journal of the American College of Cardiology · May 30, 2017 Background It remains unclear whether radial access (RA), compared with femoral access (FA), mitigates the risk of acute kidney injury (AKI). Objectives The authors assessed the incidence of AKI in patients with acute coronary syndrome (ACS) enrolled in th ... Full text Cite

Oral antiplatelet drugs in patients with chronic kidney disease (CKD): a review.

Journal Article J Thromb Thrombolysis · May 2017 Oral Antiplatelet Drugs (OAD) have a proven track record in the risk reduction of major cardiovascular events in patients with cardiovascular disease and normal kidney function. However, major gaps exist in our understanding of their effects on thrombosis ... Full text Link to item Cite

Comparative Efficacy of Coronary Revascularization Procedures for Multivessel Coronary Artery Disease in Patients With Chronic Kidney Disease.

Journal Article Am J Cardiol · May 1, 2017 Patients with chronic kidney disease (CKD) are at increased risk of cardiovascular disease and death, yet little data exist regarding the comparative efficacy of coronary revascularization procedures in CKD patients with multivessel disease. We created a c ... Full text Link to item Cite

The Role for Cardiovascular Remodeling in Cardiovascular Outcomes.

Journal Article Curr Atheroscler Rep · May 2017 PURPOSE OF REVIEW: Ischemic and non-ischemic injury to the heart causes deleterious changes in ventricular size, shape, and function. This adverse remodeling is mediated by neurohormonal and hemodynamic alterations and is reflected in non-invasive measures ... Full text Link to item Cite

Percutaneous Mechanical Circulatory Support Devices in Cardiogenic Shock.

Journal Article Circ Cardiovasc Interv · May 2017 Despite a high rate of early revascularization and use of intra-aortic balloon pump counterpulsation therapy, the prognosis of patients with cardiogenic shock has remained poor. In the hopes of improving outcomes, clinicians are increasingly turning to per ... Full text Link to item Cite

Association Between Chronic Kidney Disease and Rates of Transfusion and Progression to End-Stage Renal Disease in Patients Undergoing Transradial Versus Transfemoral Cardiac Catheterization-An Analysis From the Veterans Affairs Clinical Assessment Reporting and Tracking (CART) Program.

Journal Article J Am Heart Assoc · April 18, 2017 BACKGROUND: Patients with chronic kidney disease (CKD) are at increased risk for bleeding, transfusion, and dialysis after cardiac catheterization. Whether rates of these complications are increased in this high-risk population undergoing transradial acces ... Full text Link to item Cite

Use of Antiplatelet Therapy/DAPT for Post-PCI Patients Undergoing Noncardiac Surgery.

Journal Article J Am Coll Cardiol · April 11, 2017 Dual antiplatelet therapy (DAPT) is prescribed to millions of patients worldwide following coronary stenting. DAPT is indicated to lower the risk of ischemic events, such as myocardial infarction, including stent thrombosis, ischemic stroke, or death from ... Full text Link to item Cite

Assessment of Operator Variability in Risk-Standardized Mortality Following Percutaneous Coronary Intervention: A Report From the NCDR.

Journal Article JACC Cardiovasc Interv · April 10, 2017 OBJECTIVES: This study sought to determine variability and stability in risk-standardized mortality rates (RSMR) of percutaneous coronary intervention (PCI) operators meeting minimum case volume standards and identify differences in case mix and practice p ... Full text Link to item Cite

Lipid-lowering Therapy in Patients With High Cardiovascular Risk: Dose or Combination?

Journal Article Clin Ther · March 2017 Cardiovascular disease is the leading cause of death in the world. Dyslipidemia, manifested by elevated low-density lipoprotein cholesterol (LDL-C) levels, is central to the development and progression of atherosclerosis. Dyslipidemia has become a primary ... Full text Link to item Cite

Sex-related differences in outcomes among men and women under 55 years of age with acute coronary syndrome undergoing percutaneous coronary intervention: Results from the PROMETHEUS study.

Journal Article Catheter Cardiovasc Interv · March 1, 2017 BACKGROUND: Young women undergoing percutaneous coronary intervention (PCI) for acute coronary syndrome (ACS) experience greater adverse events than men, potentially due to under-treatment. We sought to compare the 1-year outcomes by sex in patients ≤55 ye ... Full text Link to item Cite

Costs Associated With Access Site and Same-Day Discharge Among Medicare Beneficiaries Undergoing Percutaneous Coronary Intervention: An Evaluation of the Current Percutaneous Coronary Intervention Care Pathways in the United States.

Journal Article JACC Cardiovasc Interv · February 27, 2017 OBJECTIVES: The aim of this study was to examine the independent impact of various care pathways, including those involving transradial intervention (TRI) and same-day discharge (SDD) after elective percutaneous coronary intervention (PCI), on hospital cos ... Full text Link to item Cite

Polymer-Free Drug-Coated Coronary Stents in Patients with Stable Coronary Artery Disease at High Bleeding Risk.

Journal Article Curr Cardiol Rep · February 2017 PURPOSE OF REVIEW: Patients with stable coronary artery disease (CAD) and a high risk of bleeding are not ideal candidates for a polymer-based drug-eluting stent (DES) because it requires 6-12 months of dual antiplatelet therapy (DAPT) following percutaneo ... Full text Link to item Cite

Radial artery diameter does not correlate with body mass index: A duplex ultrasound analysis of 1706 patients undergoing trans-radial catheterization at three experienced radial centers.

Journal Article Int J Cardiol · February 1, 2017 BACKGROUND: We examined whether the radial artery diameter is correlated with body mass index (BMI) in patients undergoing transradial catheterization. METHODS: 1706 patients undergoing trans-radial catheterization at three experienced, high-volume, radial ... Full text Link to item Cite

Transradial approach for coronary angiography and intervention in the elderly: A meta-analysis of 777,841 patients.

Journal Article Int J Cardiol · February 1, 2017 BACKGROUND: Studies showing an advantage of transradial approach (TR) for coronary angiography and intervention (PCI) compared to the transfemoral approach (TF) predominantly included a younger population. Therefore, we conducted a meta-analysis of publish ... Full text Link to item Cite

The Systematic Evaluation of Identifying the Infarct Related Artery Utilizing Cardiac Magnetic Resonance in Patients Presenting with ST-Elevation Myocardial Infarction.

Journal Article PLoS One · 2017 BACKGROUND: Identification of the infarct-related artery (IRA) in patients with STEMI using coronary angiography (CA) is often based on the ECG and can be challenging in patients with severe multi-vessel disease. The current study aimed to determine how of ... Full text Link to item Cite

Anticoagulation in coronary intervention.

Journal Article Eur Heart J · December 1, 2016 Percutaneous coronary intervention (PCI) induces thrombin generation and is associated with the risk of acute, subacute, or long-term ischaemic events. Therefore, intravenous anticoagulation is recommended to minimize thrombotic complications. The intensit ... Full text Link to item Cite

Comparison Between Radial Approach and Femoral Approach With Vascular Closure Devices on the Occurrence of Access-Site Complications and Periprocedural Bleeding After Percutaneous Coronary Procedures: A Systematic Review and Meta-Analysis.

Journal Article J Invasive Cardiol · December 2016 OBJECTIVES: Periprocedural bleedings, often related to vascular access site, represent an important drawback of percutaneous coronary procedures and are associated with worse outcomes. Radial access (RA) and, potentially, femoral access (FA) with vascular ... Link to item Cite

Meta-Analysis Comparing Complete Revascularization Versus Infarct-Related Only Strategies for Patients With ST-Segment Elevation Myocardial Infarction and Multivessel Coronary Artery Disease.

Journal Article Am J Cardiol · November 15, 2016 Several recent randomized controlled trials (RCTs) demonstrated better outcomes with multivessel complete revascularization (CR) than with infarct-related artery-only revascularization (IRA-OR) in patients with ST-segment elevation myocardial infarction. I ... Full text Link to item Cite

Clinical Practice Guidelines From the AABB: Red Blood Cell Transfusion Thresholds and Storage.

Journal Article JAMA · November 15, 2016 IMPORTANCE: More than 100 million units of blood are collected worldwide each year, yet the indication for red blood cell (RBC) transfusion and the optimal length of RBC storage prior to transfusion are uncertain. OBJECTIVE: To provide recommendations for ... Full text Link to item Cite

Arterial access and arteriotomy site closure devices.

Journal Article Nat Rev Cardiol · November 2016 Arterial access and haemostasis are fundamental aspects of procedures performed in the cardiac catheterization laboratory. The first description of arterial access for cardiac catheterization was in 1948, when surgical cut-down was used to access the radia ... Full text Link to item Cite

The Changing Landscape of Randomized Clinical Trials in Cardiovascular Disease.

Journal Article J Am Coll Cardiol · October 25, 2016 Large randomized clinical trials in cardiovascular disease have proliferated over the past 3 decades, with results that have influenced every aspect of cardiology practice. Despite these advances, there remains a substantial need for more high-quality evid ... Full text Link to item Cite

Controversies in the Management of ST-Segment Elevation Myocardial Infarction: Transradial Versus Transfemoral Approach.

Journal Article Interv Cardiol Clin · October 2016 This article discusses the controversies surrounding the use of transradial versus transfemoral approaches in the management of patients with ST-segment elevation myocardial infarction, beginning with a review of the benefits of transradial percutaneous co ... Full text Link to item Cite

Reply: The Hidden Players.

Journal Article JACC Cardiovasc Interv · September 26, 2016 Full text Link to item Cite

A team-based approach to patients in cardiogenic shock.

Journal Article Catheter Cardiovasc Interv · September 2016 Cardiogenic shock is a common clinical condition with high in-hospital mortality. Early application of appropriate interventions for cardiogenic shock-including medical therapies, revascularization, temporary hemodynamic support devices, and durable mechan ... Full text Link to item Cite

Blood Transfusion and the Risk of Acute Kidney Injury Among Patients With Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention.

Journal Article Circ Cardiovasc Interv · September 2016 BACKGROUND: Acute kidney injury (AKI) complicating percutaneous coronary intervention (PCI) is associated with adverse clinical outcomes. To date, no studies have evaluated the association of blood transfusion with AKI in patients undergoing PCI. METHODS A ... Full text Link to item Cite

Characteristics, treatment and in-hospital outcomes of patients with STEMI in a metropolitan area of a developing country: an initial report of the extended Jakarta Acute Coronary Syndrome registry.

Journal Article BMJ Open · August 31, 2016 OBJECTIVE: We studied the characteristics of patients with ST segment elevation myocardial infarction (STEMI) after expansion of a STEMI registry as part of the STEMI network programme in a metropolitan city and the surrounding area covering ∼26 million in ... Full text Link to item Cite

Bioabsorbable Intracoronary Matrix for Prevention of Ventricular Remodeling After Myocardial Infarction.

Journal Article J Am Coll Cardiol · August 16, 2016 BACKGROUND: Bioabsorbable cardiac matrix (BCM) is a novel device that attenuates adverse left ventricular (LV) remodeling after large myocardial infarctions in experimental models. OBJECTIVES: This study aimed to analyze whether BCM, compared with saline c ... Full text Link to item Cite

Arterial access site and outcomes in patients undergoing percutaneous coronary intervention with and without vorapaxar.

Journal Article Catheter Cardiovasc Interv · August 2016 OBJECTIVES: We evaluated outcomes associated with transradial vs. transfemoral approaches and vorapaxar in acute coronary syndrome (ACS) patients undergoing percutaneous coronary intervention (PCI) in the TRACER trial. BACKGROUND: Vorapaxar reduces ischemi ... Full text Link to item Cite

Radial Versus Femoral Access for Coronary Interventions Across the Entire Spectrum of Patients With Coronary Artery Disease: A Meta-Analysis of Randomized Trials.

Journal Article JACC Cardiovasc Interv · July 25, 2016 OBJECTIVES: The aim of this study was to provide a quantitative appraisal of the effects on clinical outcomes of radial access for coronary interventions in patients with coronary artery disease (CAD). BACKGROUND: Randomized trials investigating radial ver ... Full text Link to item Cite

Effect of Post-Primary Percutaneous Coronary Intervention Bivalirudin Infusion on Acute Stent Thrombosis: Meta-Analysis of Randomized Controlled Trials.

Journal Article JACC Cardiovasc Interv · July 11, 2016 OBJECTIVES: The aim of this study was to evaluate the efficacy of various doses of post-primary percutaneous coronary intervention (PCI) bivalirudin infusion to prevent acute stent thrombosis (AST). BACKGROUND: In several recent randomized controlled trial ... Full text Link to item Cite

Percutaneous Coronary Intervention in Native Coronary Arteries Versus Bypass Grafts in Patients With Prior Coronary Artery Bypass Graft Surgery: Insights From the Veterans Affairs Clinical Assessment, Reporting, and Tracking Program.

Journal Article JACC Cardiovasc Interv · May 9, 2016 OBJECTIVES: The aim of this study was to examine the frequency, associations, and outcomes of native coronary artery versus bypass graft percutaneous coronary intervention (PCI) in patients with prior coronary artery bypass grafting (CABG) in the Veterans ... Full text Link to item Cite

Vorapaxar and diplopia: Possible off-target PAR-receptor mismodulation.

Journal Article Thromb Haemost · May 2, 2016 Vorapaxar, a novel antiplatelet thrombin PAR-1 inhibitor, has been evaluated in the successful TRA2P trial and the failed TRACER trial. The drug is currently approved for post myocardial infarction and peripheral artery disease indications with concomitant ... Full text Link to item Cite

Characteristics of Patients Undergoing Cardiac Catheterization Before Noncardiac Surgery: A Report From the National Cardiovascular Data Registry CathPCI Registry.

Journal Article JAMA Intern Med · May 1, 2016 IMPORTANCE: Many patients undergo cardiac catheterization and/or percutaneous coronary intervention (PCI) before noncardiac surgery even though these procedures are not routinely indicated. Data on this cohort of patients are limited. OBJECTIVE: To describ ... Full text Link to item Cite

Same-Day Discharge After Percutaneous Coronary Intervention: Current Perspectives and Strategies for Implementation.

Journal Article JAMA Cardiol · May 1, 2016 IMPORTANCE: The evolution of percutaneous coronary intervention (PCI) has led to improved safety and efficacy, such that overnight observation can be avoided in some patients. We sought to provide a narrative review of the current literature regarding the ... Full text Link to item Cite

The Impact of Bleeding Avoidance Strategies on Hospital-Level Variation in Bleeding Rates Following Percutaneous Coronary Intervention: Insights From the National Cardiovascular Data Registry CathPCI Registry.

Journal Article JACC Cardiovasc Interv · April 25, 2016 OBJECTIVES: The aim of this study was to explore whether the use of bleeding avoidance strategies (BAS) explains variability in hospital-level bleeding following percutaneous coronary intervention. BACKGROUND: Prior studies have reported that bleeding rate ... Full text Link to item Cite

Meta-Analysis of Effects of Bivalirudin Versus Heparin on Myocardial Ischemic and Bleeding Outcomes After Percutaneous Coronary Intervention.

Journal Article Am J Cardiol · April 15, 2016 Bivalirudin is an alternative to unfractionated heparin (UFH) anticoagulation during percutaneous coronary intervention. Previously, we have reported clinical benefit on major bleeding in favor of bivalirudin compared with UFH monotherapy but inconclusive ... Full text Link to item Cite

Antiplatelet Therapy in Percutaneous Coronary Intervention.

Journal Article Interv Cardiol Clin · April 2016 Platelets play a key role in mediating stent thrombosis, which is the major cause of ischemic events immediately after percutaneous coronary intervention (PCI). Antiplatelet therapy is therefore the cornerstone of antithrombotic therapy after PCI. However, ... Full text Link to item Cite

Temporal Trends in the Risk Profile of Patients Undergoing Outpatient Percutaneous Coronary Intervention: A Report from the National Cardiovascular Data Registry's CathPCI Registry.

Journal Article Circ Cardiovasc Interv · March 2016 BACKGROUND: Because of recent changes in criteria for coverage for inpatient hospital stays, most nonacute percutaneous coronary intervention (PCI) procedures are reimbursed on an outpatient basis regardless of underlying patient risk. Downstream effects o ... Full text Link to item Cite

Multivessel vs culprit-only percutaneous coronary intervention among patients 65 years or older with acute myocardial infarction.

Journal Article Am Heart J · February 2016 BACKGROUND: Older adults presenting with acute myocardial infarction (MI) often have multivessel coronary artery disease amenable to percutaneous coronary intervention (PCI), yet the risks of multivessel intervention may outweigh potential benefits in thes ... Full text Link to item Cite

The National Cardiovascular Data Registry Voluntary Public Reporting Program: An Interim Report From the NCDR Public Reporting Advisory Group.

Journal Article J Am Coll Cardiol · January 19, 2016 Public reporting of health care data continues to proliferate as consumers and other stakeholders seek information on the quality and outcomes of care. Medicare's Hospital Compare website, the U.S. News & World Report hospital rankings, and several state-l ... Full text Link to item Cite

Outcomes after thrombus aspiration for ST elevation myocardial infarction: 1-year follow-up of the prospective randomised TOTAL trial.

Journal Article Lancet · January 9, 2016 BACKGROUND: Two large trials have reported contradictory results at 1 year after thrombus aspiration in ST elevation myocardial infarction (STEMI). In a 1-year follow-up of the largest randomised trial of thrombus aspiration, we aimed to clarify the longer ... Full text Link to item Cite

Safety and clinical effectiveness of drug-eluting stents for saphenous vein graft intervention in older individuals: Results from the medicare-linked National Cardiovascular Data Registry(®) CathPCI Registry(®) (2005-2009).

Journal Article Catheter Cardiovasc Interv · January 1, 2016 OBJECTIVES: To evaluate the safety of drug-eluting stents (DES) when treating patients with failing saphenous vein grafts (SVG). BACKGROUND: DES reduce target vessel revascularization in patients with failing SVGs; however, compared with bare metal stents ... Full text Link to item Cite

An updated comprehensive meta-analysis of bivalirudin vs heparin use in primary percutaneous coronary intervention.

Journal Article Am Heart J · January 2016 BACKGROUND: Despite several randomized controlled trials and meta-analyses, the ideal anticoagulant for patients undergoing primary percutaneous coronary intervention (PCI) remains controversial. We performed an updated meta-analysis including recently rep ... Full text Link to item Cite

Post-procedural/pre-hemostasis intra-arterial nitroglycerin after transradial catheterization: A gender based analysis.

Journal Article Cardiovasc Revasc Med · 2016 BACKGROUND: We analyzed the effect of nitroglycerin on radial artery occlusion (RAO) in women undergoing transradial catheterization. METHODS: A total of 1706 patients undergoing transradial catheterization were randomized to receive either 500μg intra-art ... Full text Link to item Cite

A Call for Comprehensive Forearm Access?

Journal Article J Invasive Cardiol · January 2016 Link to item Cite

The Multidimensionality of Cardiovascular Procedures.

Journal Article J Am Coll Cardiol · December 29, 2015 Full text Link to item Cite

Proficiency With Vascular Access: Don't Rob Peter to Pay Paul.

Journal Article JACC Cardiovasc Interv · December 21, 2015 Full text Link to item Cite

Transradial Versus Transfemoral Access in Patients Undergoing Rescue Percutaneous Coronary Intervention After Fibrinolytic Therapy.

Journal Article JACC Cardiovasc Interv · December 21, 2015 OBJECTIVES: The purpose of this study was to assess usage patterns of transradial access in rescue percutaneous coronary intervention (PCI) for ST-segment elevation myocardial infarction (STEMI) and associations between vascular access site choice and outc ... Full text Link to item Cite

Simplified Predictive Instrument to Rule Out Acute Coronary Syndromes in a High-Risk Population.

Journal Article J Am Heart Assoc · December 14, 2015 BACKGROUND: It is unclear whether diagnostic protocols based on cardiac markers to identify low-risk chest pain patients suitable for early release from the emergency department can be applied to patients older than 65 years or with traditional cardiac ris ... Full text Open Access Link to item Cite

Collaborative quality improvement vs public reporting for percutaneous coronary intervention: A comparison of percutaneous coronary intervention in New York vs Michigan.

Journal Article Am Heart J · December 2015 INTRODUCTION: Public reporting (PR) is a policy mechanism that may improve clinical outcomes for percutaneous coronary intervention (PCI). However, prior studies have shown that PR may have an adverse impact on patient selection. It is unclear whether alte ... Full text Link to item Cite

Radiation exposure in relation to the arterial access site used for diagnostic coronary angiography and percutaneous coronary intervention: a systematic review and meta-analysis.

Journal Article Lancet · November 28, 2015 BACKGROUND: Transradial access for cardiac catheterisation results in lower bleeding and vascular complications than the traditional transfemoral access route. However, the increased radiation exposure potentially associated with transradial access is a po ... Full text Link to item Cite

A comparison of radial and femoral access for cardiac catheterization.

Journal Article Trends Cardiovasc Med · November 2015 Over the past several years, the transradial approach (TRA) for cardiac catheterization has become increasingly adopted in the United States. The increased utilization of the TRA is grounded on 2 decades of research, showing reduced bleeding and vascular c ... Full text Link to item Cite

A randomized, double-blind, placebo-controlled trial to evaluate the safety and effectiveness of intracoronary application of a novel bioabsorbable cardiac matrix for the prevention of ventricular remodeling after large ST-segment elevation myocardial infarction: Rationale and design of the PRESERVATION I trial.

Journal Article Am Heart J · November 2015 Postinfarction left ventricular (LV) remodeling can result in chronic heart failure and functional impairment. Although pharmacological strategies for established heart failure can be beneficial, preventing remodeling remains a challenge. Injectable bioabs ... Full text Link to item Cite

Effect of Vascular Access Site Choice on Radiation Exposure During Coronary Angiography: The REVERE Trial (Randomized Evaluation of Vascular Entry Site and Radiation Exposure).

Journal Article JACC Cardiovasc Interv · August 17, 2015 OBJECTIVES: This study sought to perform a randomized noninferiority trial of radiation exposure during cardiac catheterization comparing femoral access (FA) with left radial access (LRA) and right radial access (RRA). BACKGROUND: Increased radiation expos ... Full text Link to item Cite

Comparison of quality-of-life measures after radial versus femoral artery access for cardiac catheterization in women: Results of the Study of Access Site for Enhancement of Percutaneous Coronary Intervention for Women quality-of-life substudy.

Journal Article Am Heart J · August 2015 BACKGROUND: In the SAFE-PCI for Women trial, patient preference for radial access for future procedures was greater than for femoral access. We sought to assess whether radial or femoral access impacts formal measures of quality-of-life (QOL) among women u ... Full text Link to item Cite

Impact of access site choice on outcomes of patients with cardiogenic shock undergoing percutaneous coronary intervention: A systematic review and meta-analysis.

Journal Article Am Heart J · August 2015 BACKGROUND: The benefit of transradial access (TRA) in patients with cardiogenic shock (CS) is uncertain. We sought to determine the benefits of TRA in patients with CS undergoing coronary angiography/intervention. METHODS: MEDLINE, Embase, Cochrane Centra ... Full text Link to item Cite

SCAI: Enhancing patient care through quality.

Journal Article Catheter Cardiovasc Interv · July 2015 Full text Link to item Cite

The choice of arterial access for percutaneous coronary intervention and its impact on outcome: An expert opinion perspective.

Journal Article Am Heart J · July 2015 The prevention of major bleeding during percutaneous coronary intervention is one of the most widely discussed and often controversial topics within interventional cardiology. The choice of arterial access should be considered a mechanism for bleeding avoi ... Full text Link to item Cite

Radial versus femoral access in patients with acute coronary syndromes undergoing invasive management: a randomised multicentre trial.

Journal Article Lancet · June 20, 2015 BACKGROUND: It is unclear whether radial compared with femoral access improves outcomes in unselected patients with acute coronary syndromes undergoing invasive management. METHODS: We did a randomised, multicentre, superiority trial comparing transradial ... Full text Link to item Cite

Registry-based randomized clinical trials--a new clinical trial paradigm.

Journal Article Nat Rev Cardiol · May 2015 Randomized clinical trials provide the foundation of clinical evidence to guide physicians in their selection of treatment options. Importantly, randomization is the only reliable method to control for confounding factors when comparing treatment groups. H ... Full text Link to item Cite

De-implementing the Allen's Test.

Journal Article J Invasive Cardiol · May 2015 Link to item Cite

Reply: Transradial PCI in Women: Zeroing in on Crossovers.

Journal Article JACC Cardiovasc Interv · April 20, 2015 Full text Link to item Cite

Radial Versus Femoral Access for Coronary Angiography/Intervention in Women With Acute Coronary Syndromes: Insights From the RIVAL Trial (Radial Vs femorAL access for coronary intervention).

Journal Article JACC Cardiovasc Interv · April 20, 2015 OBJECTIVES: The purpose of this study was to determine the efficacy and safety of radial versus femoral access in women undergoing coronary angiography/intervention. BACKGROUND: The risk of bleeding and vascular access site complications are higher in wome ... Full text Link to item Cite

Randomized trial of primary PCI with or without routine manual thrombectomy.

Journal Article N Engl J Med · April 9, 2015 BACKGROUND: During primary percutaneous coronary intervention (PCI), manual thrombectomy may reduce distal embolization and thus improve microvascular perfusion. Small trials have suggested that thrombectomy improves surrogate and clinical outcomes, but a ... Full text Link to item Cite

Access and non-access site bleeding after percutaneous coronary intervention and risk of subsequent mortality and major adverse cardiovascular events: systematic review and meta-analysis.

Journal Article Circ Cardiovasc Interv · April 2015 BACKGROUND: The prognostic impact of site-specific major bleeding complications after percutaneous coronary intervention (PCI) has yielded conflicting data. The aim of this study is to provide an overview of site-specific major bleeding events in contempor ... Full text Link to item Cite

Radial Approach: Fundamental Techniques and Evidence.

Journal Article Interv Cardiol Clin · April 2015 Full text Link to item Cite

Activated clotting time and outcomes during percutaneous coronary intervention for non-ST-segment-elevation myocardial infarction: insights from the FUTURA/OASIS-8 Trial.

Journal Article Circ Cardiovasc Interv · April 2015 BACKGROUND: Activated clotting time (ACT) is widely used to guide unfractionated heparin dosing during percutaneous coronary intervention. However, its value in predicting complications is controversial in the modern era. We sought to examine the relations ... Full text Link to item Cite

Hospital length of stay and clinical outcomes in older STEMI patients after primary PCI: a report from the National Cardiovascular Data Registry.

Journal Article J Am Coll Cardiol · March 31, 2015 BACKGROUND: There has been a decline in hospital length of stay (LOS) after primary percutaneous coronary intervention (PPCI) for ST-segment elevation myocardial infarction (STEMI). OBJECTIVES: The objective of this study was to examine whether shorter LOS ... Full text Link to item Cite

Randomized Trial of Primary PCI with or without Routine Manual Thrombectomy.

Journal Article N Engl J Med · March 16, 2015 Background During primary percutaneous coronary intervention (PCI), manual thrombectomy may reduce distal embolization and thus improve microvascular perfusion. Small trials have suggested that thrombectomy improves surrogate and clinical outcomes, but a l ... Full text Link to item Cite

Radial artery occlusion after transradial approach to cardiac catheterization.

Journal Article Curr Atheroscler Rep · March 2015 Radial artery occlusion (RAO) is the most common complication of the transradial approach (TRA) to cardiac catheterization, with a reported incidence between 0.8 % and 30 %. RAO is likely the result of acute thrombus formation and complicated by neointimal ... Full text Link to item Cite

Blood transfusion after percutaneous coronary intervention and risk of subsequent adverse outcomes: a systematic review and meta-analysis.

Journal Article JACC Cardiovasc Interv · March 2015 OBJECTIVES: This study sought to define the prevalence and prognostic impact of blood transfusions in contemporary percutaneous coronary intervention (PCI) practice. BACKGROUND: Although the presence of anemia is associated with adverse outcomes in patient ... Full text Link to item Cite

Three-year outcomes associated with embolic protection in saphenous vein graft intervention: results in 49 325 senior patients in the Medicare-linked National Cardiovascular Data Registry CathPCI Registry.

Journal Article Circ Cardiovasc Interv · March 2015 BACKGROUND: Information is limited on contemporary use and outcomes of embolic protection devices (EPDs) in saphenous vein graft interventions. METHODS AND RESULTS: We formed a longitudinal cohort (2005-2009; n=49 325) by linking National Cardiovascular Da ... Full text Link to item Cite

Identification of hospital outliers in bleeding complications after percutaneous coronary intervention.

Journal Article Circ Cardiovasc Qual Outcomes · January 2015 BACKGROUND: Post-percutaneous coronary intervention (PCI) bleeding complications are an important quality metric. We sought to characterize site-level variation in post-PCI bleeding and explore the influence of patient and procedural factors on hospital bl ... Full text Link to item Cite

Current State of Radial Artery Catheterization in ST-Elevation Myocardial Infarction.

Journal Article Prog Cardiovasc Dis · 2015 A well-established body of evidence demonstrating the advantages of a transradial approach for coronary angiography and intervention has led to worldwide adoption of this technique. In some countries, radial access has replaced femoral access as the domina ... Full text Link to item Cite

Temporal Trends in Bleeding among Acute Coronary Syndrome Patients: Is It Going Up or Down? Does It Matter?

Journal Article Cardiology · 2015 Bleeding is one of the most common complications among patients presenting with acute coronary syndrome (ACS) and is often precipitated by therapeutic intervention with potent antithrombotic medications and invasive procedures to restore perfusion to ische ... Full text Link to item Cite

A prospective randomized wait list control trial of intravenous iron sucrose in older adults with unexplained anemia and serum ferritin 20-200 ng/mL.

Journal Article Blood Cells Mol Dis · December 2014 Anemia is common in older persons and is associated with substantial morbidity and mortality. One third of anemic older adults have unexplained anemia of the elderly (UAE). We carried out a randomized, wait list control trial in outpatients with UAE and se ... Full text Link to item Cite

Design and rationale for the Minimizing Adverse haemorrhagic events by TRansradial access site and systemic Implementation of angioX program.

Journal Article Am Heart J · December 2014 BACKGROUND: Transradial intervention (TRI) and bivalirudin infusion compared with transfemoral coronary intervention or unfractionated heparin plus glycoprotein IIb/IIIa inhibitors decrease bleeding complications in patients with acute coronary syndromes ( ... Full text Link to item Cite

Safety and effectiveness of drug-eluting versus bare-metal stents in saphenous vein bypass graft percutaneous coronary interventions: insights from the Veterans Affairs CART program.

Journal Article J Am Coll Cardiol · October 28, 2014 BACKGROUND: Stenosis of saphenous vein grafts (SVGs) after coronary artery bypass grafting (CABG) is common and often requires percutaneous coronary interventions (PCI) for treatment. However, data for the effectiveness of drug-eluting stents (DES) versus ... Full text Link to item Cite

ABO blood group influences transfusion and survival after cardiac surgery.

Journal Article J Thromb Thrombolysis · October 2014 ABO dependent variation in von Willebrand factor (vWf) and procoagulant factor VIII (FVIII) is a plausible mechanism for modulating perioperative hemostasis and bleeding. Group AB has the highest and group O the lowest vWf and FVIII levels. Therefore, we t ... Full text Link to item Cite

Design and rationale of the ANALYZE ST study: a prospective, nonrandomized, multicenter ST monitoring study to detect acute coronary syndrome events in implantable cardioverter-defibrillator patients.

Journal Article Am Heart J · October 2014 BACKGROUND: In the setting of ST-segment elevation myocardial infarction, timely restoration of normal blood flow is associated with improved myocardial salvage and survival. Despite improvements in door-to-needle and door-to-balloon times, there remains a ... Full text Link to item Cite

Prospective validation of the Bleeding Academic Research Consortium classification in the all-comer PRODIGY trial.

Journal Article Eur Heart J · October 1, 2014 AIMS: The Bleeding Academic Research Consortium (BARC) classification has been proposed by consensus to standardize bleeding endpoint definition and reporting in cardiovascular clinical trials. There are no prospective studies on its prognostic impact. MET ... Full text Link to item Cite

Safety and clinical outcome of erythropoiesis-stimulating agents in patients with ST-elevation myocardial infarction: a meta-analysis of individual patient data.

Journal Article Am Heart J · September 2014 BACKGROUND: Erythropoiesis-stimulating agents (ESAs) have been investigated in small studies in patients with ST-elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI). Erythropoiesis-stimulating agents did not ... Full text Link to item Cite

A registry-based randomized trial comparing radial and femoral approaches in women undergoing percutaneous coronary intervention: the SAFE-PCI for Women (Study of Access Site for Enhancement of PCI for Women) trial.

Journal Article JACC Cardiovasc Interv · August 2014 OBJECTIVES: This study sought to determine the effect of radial access on outcomes in women undergoing percutaneous coronary intervention (PCI) using a registry-based randomized trial. BACKGROUND: Women are at increased risk of bleeding and vascular compli ... Full text Link to item Cite

Minimizing femoral artery access complications during percutaneous coronary intervention: a comprehensive review.

Journal Article Catheter Cardiovasc Interv · July 1, 2014 Major bleeding complications after percutaneous coronary intervention (PCI) increase patient morbidity, prolong the hospital stay and costs, and are associated with reduced survival. Transfemoral access is still preferred at many centers given its familiar ... Full text Link to item Cite

Change in hospital-level use of transradial percutaneous coronary intervention and periprocedural outcomes: insights from the national cardiovascular data registry.

Journal Article Circ Cardiovasc Qual Outcomes · July 2014 BACKGROUND: Whether increasing use of radial access has improved percutaneous coronary intervention outcomes remains unknown. We sought to determine the relationship between increasing facility-level use of transradial percutaneous coronary intervention (T ... Full text Link to item Cite

The learning curve for transradial percutaneous coronary intervention among operators in the United States: a study from the National Cardiovascular Data Registry.

Journal Article Circulation · June 3, 2014 BACKGROUND: Adoption of transradial percutaneous coronary intervention (TRI) in the United States is low and may be related to challenges learning the technique. We examined the relationships between operator TRI volume and procedural metrics and outcomes. ... Full text Link to item Cite

Elinogrel

Chapter · June 3, 2014 Antiplatelet therapy remains a cornerstone in the management of patients with coronary artery disease. Advances in platelet inhibition have led to the development of dual antiplatelet therapy that involves treatment with both aspirin and a P2Y12 receptor i ... Full text Cite

Staying ahead of the curve.

Journal Article Cardiovasc Revasc Med · June 2014 Full text Link to item Cite

Bleeding Complications After PCI and the Role of Transradial Access.

Journal Article Curr Treat Options Cardiovasc Med · May 2014 Bleeding events are the most common complications following percutaneous coronary intervention (PCI) and are associated with increases in short- and long-term mortality, nonfatal myocardial infarction, stroke, hospital length of stay, and hospital cost. Ov ... Full text Link to item Cite

Conversations in cardiology: bridging antiplatelet therapy before surgery.

Journal Article Catheter Cardiovasc Interv · April 1, 2014 Bridging for antiplatelet therapy remains a subject of debate with data favoring GP blockers but at a risk of bleeding. This Conversation in Cardiology addresses a key and often asked question about use of alternatives to P2Y12 agents in patients requiring ... Full text Link to item Cite

Predicting target vessel revascularization in older patients undergoing percutaneous coronary intervention in the drug-eluting stent era.

Journal Article Am Heart J · April 2014 BACKGROUND: The contemporary need for repeat revascularization in older patients after percutaneous coronary intervention (PCI) has not been well studied. Understanding repeat revascularization risk in this population may inform treatment decisions. METHOD ... Full text Link to item Cite

Clinical outcomes after hybrid coronary revascularization versus coronary artery bypass surgery: a meta-analysis of 1,190 patients.

Journal Article Am Heart J · April 2014 BACKGROUND: Hybrid coronary revascularization (HCR) represents a minimally invasive revascularization strategy in which the durability of the internal mammary artery to left anterior descending artery graft is combined with percutaneous coronary interventi ... Full text Link to item Cite

Risk of acute kidney injury after percutaneous coronary interventions using radial versus femoral vascular access: insights from the Blue Cross Blue Shield of Michigan Cardiovascular Consortium.

Journal Article Circ Cardiovasc Interv · April 2014 BACKGROUND: Transradial percutaneous coronary intervention (PCI [TRI]) does not involve catheter manipulation in the descending aorta, whereas transfemoral PCI (TFI) does. Therefore, the risk of acute kidney injury (AKI) after PCI might be influenced by va ... Full text Link to item Cite

Design and rationale of the TOTAL trial: a randomized trial of routine aspiration ThrOmbecTomy with percutaneous coronary intervention (PCI) versus PCI ALone in patients with ST-elevation myocardial infarction undergoing primary PCI.

Journal Article Am Heart J · March 2014 BACKGROUND: A major limitation of primary percutaneous coronary intervention (PPCI) for the treatment of ST-elevation myocardial infarction (STEMI) is impaired microvascular perfusion due to embolization and obstruction of microcirculation with thrombus. M ... Full text Link to item Cite

Patterns and outcomes of red blood cell transfusion in patients undergoing percutaneous coronary intervention.

Journal Article JAMA · February 26, 2014 IMPORTANCE: Studies have shown variation in the use of red blood cell transfusion among patients with acute coronary syndromes. There are no definitive data for the efficacy of transfusion in improving outcomes, and concerning data exist about possible ass ... Full text Link to item Cite

Balloon-assisted tracking: a must-know technique to overcome difficult anatomy during transradial approach.

Journal Article Catheter Cardiovasc Interv · February 2014 OBJECTIVE: To examine the use and outcomes of balloon-assisted tracking (BAT) technique for dealing with complexities of arm and chest vasculature during transradial approach (TRA) at a single high volume radial center. BACKGROUND: TRA has been used for co ... Full text Link to item Cite

Comparative effectiveness of drug-eluting stents on long-term outcomes in elderly patients treated for in-stent restenosis: a report from the National Cardiovascular Data Registry.

Journal Article Catheter Cardiovasc Interv · February 2014 OBJECTIVE: We assessed the long-term outcomes of elderly patients who had in-stent restenosis (ISR) treated with drug-eluting stents (DES) compared with other treatment strategies. BACKGROUND: Elderly patients with ISR represent a vulnerable group of which ... Full text Link to item Cite

Anticoagulation in transradial percutaneous coronary intervention.

Journal Article Catheter Cardiovasc Interv · February 2014 Transradial percutaneous coronary intervention (PCI) is associated with significant reductions in access site complications and major bleeding as compared with the transfemoral approach. Bivalirudin is now the most commonly used anticoagulant for transradi ... Full text Link to item Cite

Perceptions of advantages and barriers to radial-access percutaneous coronary intervention in VA cardiac catheterization laboratories.

Journal Article Cardiovasc Revasc Med · 2014 BACKGROUND/PURPOSE: Compared with trans-femoral percutaneous coronary intervention (TFI), trans-radial PCI (TRI) has a lower risk of bleeding, access site complications and hospital costs, and is preferred by patients. However, TRI accounts for a minority ... Full text Link to item Cite

Major bleeding after percutaneous coronary intervention and risk of subsequent mortality: a systematic review and meta-analysis.

Journal Article Open Heart · 2014 OBJECTIVES: To examine the relationship between periprocedural bleeding complications and major adverse cardiovascular events (MACEs) and mortality outcomes following percutaneous coronary intervention (PCI) and study differences in the prognostic impact o ... Full text Link to item Cite

The current state of medical simulation in interventional cardiology: a clinical document from the Society for Cardiovascular Angiography and Intervention's (SCAI) Simulation Committee.

Journal Article Catheter Cardiovasc Interv · January 1, 2014 OBJECTIVES: To assess the current use and application of simulators in interventional cardiology. BACKGROUND: Despite a paucity of data on the efficacy of simulation in medicine, cardiovascular simulation training is now a mandated part of cardiovascular f ... Full text Link to item Cite

Comparison of bivalirudin versus heparin(s) during percutaneous coronary interventions in patients receiving prasugrel: a propensity-matched study.

Journal Article Clin Cardiol · January 2014 BACKGROUND: Several percutaneous coronary intervention (PCI) trials have established that the use of bivalirudin (BIV) is associated with improved patient outcomes and substantial hospital cost savings, relative to heparin (HEP)-based regimens±glycoprotein ... Full text Link to item Cite

Patient and hospital characteristics associated with inappropriate percutaneous coronary interventions.

Journal Article J Am Coll Cardiol · December 17, 2013 OBJECTIVES: This study sought to examine whether rates of inappropriate percutaneous coronary intervention (PCI) differ by demographic characteristics and insurance status. BACKGROUND: Prior studies have found that blacks, women, and those who have public ... Full text Link to item Cite

Consensus and update on the definition of on-treatment platelet reactivity to adenosine diphosphate associated with ischemia and bleeding.

Journal Article J Am Coll Cardiol · December 17, 2013 Dual antiplatelet therapy with aspirin and a P2Y12 receptor blocker is a key strategy to reduce platelet reactivity and to prevent thrombotic events in patients treated with percutaneous coronary intervention. In an earlier consensus document, we proposed ... Full text Link to item Cite

Radial versus femoral approach comparison in percutaneous coronary intervention with intraaortic balloon pump support: the RADIAL PUMP UP registry.

Journal Article Am Heart J · December 2013 BACKGROUND: The role of intraaortic balloon pump (IABP) during percutaneous coronary intervention (PCI) in high-risk acute patients remains debated. Device-related complications and the more complex patient management could explain such lack of clinical be ... Full text Link to item Cite

Wearable cardioverter-defibrillator use in patients perceived to be at high risk early post-myocardial infarction.

Journal Article J Am Coll Cardiol · November 19, 2013 OBJECTIVES: The aim of this study was to describe usage of the wearable cardioverter-defibrillator (WCD) during mandated waiting periods following myocardial infarction (MI) for patients perceived to be at high risk for sudden cardiac arrest (SCA). BACKGRO ... Full text Link to item Cite

EPC mobilization after erythropoietin treatment in acute ST-elevation myocardial infarction: the REVEAL EPC substudy.

Journal Article J Thromb Thrombolysis · November 2013 Erythropoietin (EPO) was hypothesized to mitigate reperfusion injury, in part via mobilization of endothelial progenitor cells (EPCs). The REVEAL trial found no reduction in infarct size with a single dose of EPO (60,000 U) in patients with ST-segment elev ... Full text Link to item Cite

Radial versus femoral access.

Journal Article J Am Coll Cardiol · October 22, 2013 Full text Link to item Cite

Radial artery approach

Chapter · October 5, 2013 Cite

Response to Dr Sandar et al.

Journal Article Am Heart J · October 2013 Full text Link to item Cite

Anticoagulation with otamixaban and ischemic events in non-ST-segment elevation acute coronary syndromes: the TAO randomized clinical trial.

Journal Article JAMA · September 18, 2013 IMPORTANCE: The optimal anticoagulant for patients with non-ST-segment elevation acute coronary syndromes (NSTE-ACS) managed with an invasive strategy remains controversial. OBJECTIVE: To compare the clinical efficacy and safety of otamixaban, a novel intr ... Full text Link to item Cite

Embedding a randomized clinical trial into an ongoing registry infrastructure: unique opportunities for efficiency in design of the Study of Access site For Enhancement of Percutaneous Coronary Intervention for Women (SAFE-PCI for Women).

Journal Article Am Heart J · September 2013 Women are at higher risk than men for bleeding and vascular complications after percutaneous coronary intervention (PCI). Compared with femoral access, radial access reduces these complications but may be more challenging in women because of higher rates o ... Full text Link to item Cite

An updated bleeding model to predict the risk of post-procedure bleeding among patients undergoing percutaneous coronary intervention: a report using an expanded bleeding definition from the National Cardiovascular Data Registry CathPCI Registry.

Journal Article JACC Cardiovasc Interv · September 2013 OBJECTIVES: This study sought to develop a model that predicts bleeding complications using an expanded bleeding definition among patients undergoing percutaneous coronary intervention (PCI) in contemporary clinical practice. BACKGROUND: New knowledge abou ... Full text Link to item Cite

In-hospital outcomes of percutaneous coronary interventions in extremely obese and normal-weight patients: findings from the NCDR (National Cardiovascular Data Registry).

Journal Article J Am Coll Cardiol · August 20, 2013 OBJECTIVES: The purpose of this study was to compare in-hospital outcomes of percutaneous coronary intervention (PCI) in extreme obesity (EO) (body mass index [BMI] ≥ 40 kg/m²) with those of normal-weight (NW) patients and to examine the influence of acces ... Full text Link to item Cite

Temporal trends in percutaneous coronary intervention outcomes among older patients in the United States.

Conference Am Heart J · August 2013 BACKGROUND: New percutaneous coronary intervention (PCI) device technologies are often rapidly adopted into clinical practice, yet few studies have examined the overall impact of these new technologies on patient outcomes in community practice. METHODS: In ... Full text Link to item Cite

The value proposition in percutaneous coronary intervention.

Journal Article JACC Cardiovasc Interv · August 2013 Full text Link to item Cite

Enhanced mortality risk prediction with a focus on high-risk percutaneous coronary intervention: results from 1,208,137 procedures in the NCDR (National Cardiovascular Data Registry).

Journal Article JACC Cardiovasc Interv · August 2013 OBJECTIVES: This study sought to update and validate a contemporary model for inpatient mortality following percutaneous coronary intervention (PCI), including variables indicating high clinical risk. BACKGROUND: Recently, new variables were added to the C ... Full text Link to item Cite

Adoption of transradial percutaneous coronary intervention and outcomes according to center radial volume in the Veterans Affairs Healthcare system: insights from the Veterans Affairs clinical assessment, reporting, and tracking (CART) program.

Journal Article Circ Cardiovasc Interv · August 2013 BACKGROUND: Studies examining the association between radial approach and post-percutaneous coronary intervention (PCI) bleeding and mortality have reached conflicting conclusions. There are no current data about the use and outcomes of transradial PCI (r- ... Full text Link to item Cite

Comparison of bivalirudin and radial access across a spectrum of preprocedural risk of bleeding in percutaneous coronary intervention: analysis from the national cardiovascular data registry.

Journal Article Circ Cardiovasc Interv · August 2013 BACKGROUND: Bleeding is a common, noncardiac, preventable complication of percutaneous coronary intervention. We compared the relative safety of radial access and bivalirudin in percutaneous coronary intervention. METHODS AND RESULTS: From CathPCI Registry ... Full text Link to item Cite

Feasibility and utility of pre-procedure ultrasound imaging of the arm to facilitate transradial coronary diagnostic and interventional procedures (PRIMAFACIE-TRI).

Journal Article Catheter Cardiovasc Interv · July 1, 2013 OBJECTIVES: To assess feasibility and utility of imaging of both arms using ultrasound to facilitate transradial (TR) and transulnar (TU) coronary angiograms (CA) and intervention. BACKGROUND: Despite well recognized advantages, transradial approach (TRA) ... Full text Link to item Cite

Prognostic significance of bleeding location and severity among patients with acute coronary syndromes.

Journal Article JACC Cardiovasc Interv · July 2013 OBJECTIVES: This study sought to determine if there is an association between bleed location and clinical outcomes in acute coronary syndromes (ACS) patients. BACKGROUND: The prognostic significance of bleeding location among ACS patients undergoing cardia ... Full text Link to item Cite

Adoption of radial access and comparison of outcomes to femoral access in percutaneous coronary intervention: an updated report from the national cardiovascular data registry (2007-2012).

Journal Article Circulation · June 11, 2013 BACKGROUND: Radial access for percutaneous coronary intervention (r-PCI) is associated with reduced vascular complications; however, previous reports have shown that <2% of percutaneous coronary intervention (PCI) procedures in the United States are perfor ... Full text Link to item Cite

Reply: To PMID 23265340.

Journal Article J Am Coll Cardiol · June 11, 2013 Full text Link to item Cite

Radial first: paradox+proficiency=opportunity.

Journal Article J Am Heart Assoc · June 7, 2013 Full text Link to item Cite

Liberal versus restrictive transfusion thresholds for patients with symptomatic coronary artery disease.

Journal Article Am Heart J · June 2013 BACKGROUND: Prior trials suggest it is safe to defer transfusion at hemoglobin levels above 7 to 8 g/dL in most patients. Patients with acute coronary syndrome may benefit from higher hemoglobin levels. METHODS: We performed a pilot trial in 110 patients w ... Full text Link to item Cite

Patterns of use and comparative effectiveness of bleeding avoidance strategies in men and women following percutaneous coronary interventions: an observational study from the National Cardiovascular Data Registry.

Journal Article J Am Coll Cardiol · May 21, 2013 OBJECTIVES: This study sought to compared the use and effectiveness of bleeding avoidance strategies (BAS) by sex. BACKGROUND: Women have higher rates of bleeding following percutaneous coronary intervention (PCI). METHODS: Among 570,777 men (67.5%) and wo ... Full text Link to item Cite

Incorporation of bleeding as an element of the composite end point in clinical trials of antithrombotic therapies in patients with non-ST-segment elevation acute coronary syndrome: validity, pitfalls, and future approaches.

Journal Article Am Heart J · May 2013 With the large number of antithrombotic therapies available and under investigation for the treatment of non-ST-segment elevation acute coronary syndromes (NSTE ACS), practice guidelines now stress the importance of selecting an antithrombotic strategy acc ... Full text Link to item Cite

Acute coronary syndromes: Blood transfusion in patients with acute MI and anaemia.

Journal Article Nat Rev Cardiol · April 2013 In a meta-analysis of predominantly observational data, blood transfusion was independently associated with adverse outcomes in patients with myocardial infarction. These findings are consistent with previously published research, but clinical application ... Full text Link to item Cite

Radial versus femoral access, bleeding and ischemic events in patients with non-ST-segment elevation acute coronary syndrome managed with an invasive strategy.

Journal Article Am Heart J · April 2013 BACKGROUND: Bleeding is a major limitation of antithrombotic therapy among invasively managed non-ST-segment elevation acute coronary syndromes (NSTE-ACS) patients; therefore, we examined the use of radial access and its association with outcomes among NST ... Full text Link to item Cite

Association between bleeding events and in-hospital mortality after percutaneous coronary intervention.

Journal Article JAMA · March 13, 2013 IMPORTANCE: Bleeding is the most common complication after percutaneous coronary intervention (PCI) and is associated with increased morbidity and health care costs. The incidence of bleeding-related mortality after PCI has not been described in a national ... Full text Link to item Cite

TransRadial Education and Therapeutics (TREAT): shifting the balance of safety and efficacy of antithrombotic agents in percutaneous coronary intervention: a report from the Cardiac Safety Research Consortium.

Journal Article Am Heart J · March 2013 Percutaneous coronary intervention (PCI) is an integral part of the treatment of coronary artery disease. The most common complication of PCI, bleeding, typically occurs at the vascular access site and is associated with short-term and long-term morbidity ... Full text Link to item Cite

Effect of radial versus femoral access on radiation dose and the importance of procedural volume: a substudy of the multicenter randomized RIVAL trial.

Journal Article JACC Cardiovasc Interv · March 2013 OBJECTIVES: The authors sought to compare the radiation dose between radial and femoral access. BACKGROUND: Small trials have shown an increase in the radiation dose with radial compared with femoral access, but many were performed during the operators' le ... Full text Link to item Cite

Consensus document on the radial approach in percutaneous cardiovascular interventions: position paper by the European Association of Percutaneous Cardiovascular Interventions and Working Groups on Acute Cardiac Care** and Thrombosis of the European Society of Cardiology.

Journal Article EuroIntervention · March 2013 Radial access use has been growing steadily but, despite encouraging results, still varies greatly among operators, hospitals, countries and continents. Twenty years from its introduction, it was felt that the time had come to develop a common evidence-bas ... Full text Link to item Cite

An international survey of clinical practice during primary percutaneous coronary intervention for ST-elevation myocardial infarction with a focus on aspiration thrombectomy.

Journal Article EuroIntervention · February 22, 2013 AIMS: Data suggest that there is a variable use of thrombectomy during primary percutaneous coronary interventions (PPCI). We sought to evaluate practices during PPCI for ST-elevation myocardial infarction (STEMI), including the use of aspiration thrombect ... Full text Link to item Cite

Association of systemic lupus erythematosus with angiographically defined coronary artery disease: a retrospective cohort study.

Journal Article Arthritis Care Res (Hoboken) · February 2013 OBJECTIVE: To determine if systemic lupus erythematosus (SLE) is associated with a higher prevalence of coronary artery disease (CAD) in select patients undergoing coronary angiography. We compared the extent of angiographic abnormalities, CAD risk factors ... Full text Link to item Cite

Same-day discharge compared with overnight hospitalization after uncomplicated percutaneous coronary intervention: a systematic review and meta-analysis.

Journal Article JACC Cardiovasc Interv · February 2013 OBJECTIVES: This study sought to evaluate outcomes of same-day discharge (SDD) following percutaneous coronary intervention (PCI) versus overnight hospitalization (ON). BACKGROUND: Although there are data on the safety and feasibility of SDD after PCI, ON ... Full text Link to item Cite

The prevalence and outcomes of transradial percutaneous coronary intervention for ST-segment elevation myocardial infarction: analysis from the National Cardiovascular Data Registry (2007 to 2011).

Journal Article J Am Coll Cardiol · January 29, 2013 OBJECTIVES: The purpose of this study was to examine use and describe outcomes of radial access for percutaneous coronary intervention (PCI) in patients with ST-segment elevation myocardial infarction (STEMI). BACKGROUND: Transradial PCI (TRI) is associate ... Full text Link to item Cite

Hemodynamic findings in severe tricuspid regurgitation.

Journal Article Catheter Cardiovasc Interv · January 1, 2013 Tricuspid regurgitation (TR) most commonly occurs in response to right ventricular (RV) dilation with structural abnormalities in the tricuspid valve being rarer. In addition to RV size and valvular integrity, the amount of TR is influenced by RV preload a ... Full text Link to item Cite

Effects of radial versus femoral artery access in patients with acute coronary syndromes with or without ST-segment elevation.

Journal Article J Am Coll Cardiol · December 18, 2012 OBJECTIVES: The purpose of this study was to determine the consistency of the effects of radial artery access in patients with ST-segment elevation myocardial infarction (STEMI) and in those with non-ST-segment elevation acute coronary syndrome (NSTEACS). ... Full text Link to item Cite

Red blood cell transfusion: In response

Journal Article Annals of Internal Medicine · November 20, 2012 Full text Cite

Short- and long-term outcomes of coronary stenting in women versus men: results from the National Cardiovascular Data Registry Centers for Medicare & Medicaid services cohort.

Journal Article Circulation · October 30, 2012 BACKGROUND: Conflicting evidence exists on sex-based outcomes after coronary stenting. METHODS AND RESULTS: Data on 426 996 patients ≥65 years old (42.3% women) from the National Cardiovascular Data Registry CathPCI Registry (2004-2008) were linked to Medi ... Full text Link to item Cite

Antithrombotic Strategies in Patients Undergoing Elective Percutaneous Coronary Intervention

Journal Article · October 3, 2012 The goals of antithrombotic therapy during percutaneous coronary intervention are to mitigate thrombotic complications associated with iatrogenic plaque disruption from the angioplasty balloon or stent and embolization of thrombotic material from procedura ... Full text Cite

Clinical update: Remaining challenges and opportunities for improvement in percutaneous transradial coronary procedures.

Journal Article Eur Heart J · October 2012 The adoption of transradial coronary angiography and coronary intervention is growing because of emerging data on its potential advantages over the femoral approach. As the adoption of radial procedures increases, it is important to understand the remainin ... Full text Link to item Cite

Association between periprocedural bleeding and long-term outcomes following percutaneous coronary intervention in older patients.

Journal Article JACC Cardiovasc Interv · September 2012 OBJECTIVES: The authors sought to describe the association between post-procedural bleeding and long-term recurrent bleeding, major adverse cardiac events (MACE), and mortality among older patients undergoing percutaneous coronary intervention (PCI). BACKG ... Full text Link to item Cite

Meta-analysis comparing bivalirudin versus heparin monotherapy on ischemic and bleeding outcomes after percutaneous coronary intervention.

Journal Article Am J Cardiol · August 15, 2012 With femoral access, bivalirudin decreases risks of major bleeding after percutaneous coronary intervention (PCI) and provides better net clinical benefit compared to unfractionated heparin (UFH) plus planned glycoprotein IIb/IIIa inhibitors. Whether this ... Full text Link to item Cite

The association of in-hospital major bleeding with short-, intermediate-, and long-term mortality among older patients with non-ST-segment elevation myocardial infarction.

Journal Article Eur Heart J · August 2012 AIMS: Bleeding complications have been associated with short-term mortality in patients with non-ST-segment elevation myocardial infarction (NSTEMI). Their association with long-term outcomes is less clear. This study examines mortality associated with in- ... Full text Link to item Cite

Radial versus femoral access for percutaneous coronary intervention: implications for vascular complications and bleeding.

Journal Article Curr Cardiol Rep · August 2012 Since its advent over two decades ago, transradial access for cardiac catheterization and percutaneous intervention has evolved into a versatile and evidence-based approach for containing the risks of access-site bleeding and vascular complications without ... Full text Link to item Cite

Bivalirudin versus unfractionated heparin in percutaneous coronary interventions of patients having received initial fondaparinux treatment: a propensity matched study.

Journal Article EuroIntervention · August 2012 AIMS: Fondaparinux is an indirect, Factor Xa inhibitor that requires co-administration of another anticoagulant with anti-Factor IIa activity for percutaneous coronary intervention (PCI) per guideline recommendations. In this setting, the use of bivalirudi ... Full text Link to item Cite

Red blood cell transfusion: a clinical practice guideline from the AABB*.

Journal Article Ann Intern Med · July 3, 2012 DESCRIPTION: Although approximately 85 million units of red blood cells (RBCs) are transfused annually worldwide, transfusion practices vary widely. The AABB (formerly, the American Association of Blood Banks) developed this guideline to provide clinical r ... Full text Link to item Cite

Pharmacokinetic and pharmacodynamic effects of elinogrel: results of the platelet function substudy from the intravenous and oral administration of elinogrel to evaluate tolerability and efficacy in nonurgent percutaneous coronary intervention patients (INNOVATE-PCI) trial.

Journal Article Circ Cardiovasc Interv · June 2012 BACKGROUND: Elinogrel is the only selective, competitive and reversible platelet P2Y(12) inhibitor available in both intravenous (IV) and oral formulations. METHODS AND RESULTS: This substudy of the Intravenous and Oral Administration of Elinogrel to Evalu ... Full text Link to item Cite

A randomized, double-blind, active-controlled phase 2 trial to evaluate a novel selective and reversible intravenous and oral P2Y12 inhibitor elinogrel versus clopidogrel in patients undergoing nonurgent percutaneous coronary intervention: the INNOVATE-PCI trial.

Journal Article Circ Cardiovasc Interv · June 2012 BACKGROUND: We evaluated the safety, efficacy, and tolerability of elinogrel, a competitive, reversible intravenous and oral P2Y(12) inhibitor that does not require metabolic activation, in patients undergoing nonurgent percutaneous coronary intervention. ... Full text Link to item Cite

Temporal trends in and factors associated with bleeding complications among patients undergoing percutaneous coronary intervention: a report from the National Cardiovascular Data CathPCI Registry.

Journal Article J Am Coll Cardiol · May 22, 2012 OBJECTIVES: The purpose of this study was to examine temporal trends in post-percutaneous coronary intervention (PCI) bleeding among patients with elective PCI, unstable angina (UA)/non-ST-segment elevation myocardial infarction (NSTEMI), and ST-segment el ... Full text Link to item Cite

Impact of anemia on platelet response to clopidogrel in patients undergoing percutaneous coronary stenting.

Journal Article Am J Cardiol · April 15, 2012 High residual platelet reactivity (HRPR) on clopidogrel is a predictor of recurrent ischemic events in patients undergoing percutaneous coronary interventions (PCI). Significant intraindividual variability in platelet aggregation on repeat testing has been ... Full text Link to item Cite

Association of bleeding and in-hospital mortality in black and white patients with st-segment-elevation myocardial infarction receiving reperfusion.

Journal Article Circulation · April 10, 2012 BACKGROUND: Prior studies have suggested that blacks with acute ST-segment-elevation myocardial infarction have increased bleeding risks with fibrinolysis relative to whites, yet these data were quite limited. Additionally, it is unknown whether there are ... Full text Link to item Cite

Comparison of transradial and femoral approaches for percutaneous coronary interventions: a systematic review and hierarchical Bayesian meta-analysis.

Journal Article Am Heart J · April 2012 BACKGROUND: Despite lower risks of access site-related complications with transradial approach (TRA), its clinical benefit for percutaneous coronary intervention (PCI) is uncertain. We conducted a systematic review and meta-analysis of clinical studies com ... Full text Link to item Cite

Evaluating the bite of the BARC.

Journal Article Circulation · March 20, 2012 Full text Link to item Cite

Characteristics and long-term outcomes of percutaneous revascularization of unprotected left main coronary artery stenosis in the United States: a report from the National Cardiovascular Data Registry, 2004 to 2008.

Journal Article J Am Coll Cardiol · February 14, 2012 OBJECTIVES: This study sought to assess percutaneous coronary intervention (PCI) for unprotected left main coronary artery (ULMCA) stenosis in routine U.S. clinical practice. BACKGROUND: Percutaneous coronary intervention for ULMCA stenosis is controversia ... Full text Link to item Cite

Bleeding and the use of antiplatelet agents in the management of acute coronary syndromes and atrial fibrillation.

Journal Article Adv Cardiol · 2012 Antiplatelet therapy serves an important role in the management of acute coronary syndromes and in reducing the risk of thrombotic complications from atrial fibrillation. There has been rapid development of newer and more potent antiplatelet therapies over ... Full text Link to item Cite

Cardiogenic shock and awe.

Journal Article Cardiology · 2012 Full text Link to item Cite

Trends and predictors of length of stay after primary percutaneous coronary intervention: a report from the CathPCI registry.

Journal Article Am Heart J · December 2011 BACKGROUND: Post hoc analyses of clinical trials suggest that certain patients are eligible for early discharge after ST-segment elevation myocardial infarction. The extent to which ST-segment elevation myocardial infarction patients are discharged early a ... Full text Link to item Cite

Comparison of bare-metal and drug-eluting stents in patients with chronic kidney disease (from the NHLBI Dynamic Registry).

Journal Article Am J Cardiol · December 1, 2011 Patients with chronic kidney disease (CKD) have a disproportionate burden of coronary artery disease and commonly undergo revascularization. The role and safety of percutaneous coronary intervention (PCI) using drug-eluting stents (DESs) verses bare-metal ... Full text Link to item Cite

Transradial arterial access for coronary and peripheral procedures: executive summary by the Transradial Committee of the SCAI.

Journal Article Catheter Cardiovasc Interv · November 15, 2011 In response to growing U.S. interest, the Society for Coronary Angiography and Interventions recently formed a Transradial Committee whose purpose is to examine the utility, utilization, and training considerations related to transradial access for percuta ... Full text Link to item Cite

Reply

Journal Article JACC: Cardiovascular Interventions · November 1, 2011 Full text Cite

Bleeding and acute coronary syndromes: defining, predicting, and managing risk and outcomes.

Journal Article Curr Drug Targets · November 2011 Acute coronary syndromes (ACS) continue to have a large impact on morbidity and mortality in the United States. Over the last two decades, there have been several advancements in the care of patients with ACS. The use of combined antiplatelet and anticoagu ... Full text Link to item Cite

Conservative versus liberal red cell transfusion in acute myocardial infarction (the CRIT Randomized Pilot Study).

Journal Article Am J Cardiol · October 15, 2011 Red blood cell transfusion is common in patients with acute myocardial infarction (AMI). However, observational data suggest that this practice may be associated with worse clinical outcomes and data from clinical trials are lacking in this population. We ... Full text Link to item Cite

Prevalence and outcomes of same-day discharge after elective percutaneous coronary intervention among older patients.

Journal Article JAMA · October 5, 2011 CONTEXT: Patients undergoing elective percutaneous coronary intervention (PCI) are generally observed overnight in the hospital. The association between same-day discharge of older patients and death or readmission is unclear. OBJECTIVE: To evaluate the pr ... Full text Link to item Cite

Bleeding risk comparing targeted low-dose heparin with bivalirudin in patients undergoing percutaneous coronary intervention: results from a propensity score-matched analysis of the Evaluation of Drug-Eluting Stents and Ischemic Events (EVENT) registry.

Journal Article Circ Cardiovasc Interv · October 1, 2011 BACKGROUND: Prior randomized trials have shown reduced bleeding with bivalirudin compared with unfractionated heparin (UFH) in patients undergoing percutaneous coronary intervention (PCI). However, it is not known if this benefit is also present when UFH d ... Full text Link to item Cite

Transradial percutaneous coronary intervention in patients with acute coronary syndromes

Journal Article Acute Coronary Syndromes · September 5, 2011 Percutaneous coronary intervention (PCI), either performed as a primary intervention for ST-segment elevation myocardial infarction (STEMI) or as part of an early invasive strategy for high-risk non-STEMI, in combination with pharmacological advances has l ... Cite

Percutaneous coronary intervention in native arteries versus bypass grafts in prior coronary artery bypass grafting patients: a report from the National Cardiovascular Data Registry.

Journal Article JACC Cardiovasc Interv · August 2011 OBJECTIVES: This study examined a large registry to determine the frequency, predictors, and outcomes of native coronary artery versus bypass graft percutaneous coronary intervention (PCI) in patients with prior coronary artery bypass graft surgery (CABG). ... Full text Link to item Cite

Bleeding in acute coronary syndromes and percutaneous coronary interventions: position paper by the Working Group on Thrombosis of the European Society of Cardiology.

Journal Article Eur Heart J · August 2011 Bleeding has recently emerged as an important outcome in the management of acute coronary syndromes (ACS), which is relatively frequent compared with ischaemic outcomes and has important implications in terms of prognosis, outcomes, and costs. In particula ... Full text Link to item Cite

Bleeding avoidance strategies. Consensus and controversy.

Journal Article J Am Coll Cardiol · June 28, 2011 Bleeding complications after coronary intervention are associated with prolonged hospitalization, increased hospital costs, patient dissatisfaction, morbidity, and 1-year mortality. Bleeding avoidance strategies is a term incorporating multiple modalities ... Full text Link to item Cite

Atrial fibrillation and percutaneous coronary intervention: stroke, thrombosis, and bleeding.

Journal Article Curr Treat Options Cardiovasc Med · June 2011 Currently available data suggest that patients with atrial fibrillation (AF) undergoing percutaneous coronary intervention (PCI) with stenting who do not continue oral anticoagulation are at increased risk for mortality and morbidity. In this patient popul ... Full text Link to item Cite

Operator radiation exposure during percutaneous coronary procedures through the left or right radial approach: the TALENT dosimetric substudy.

Journal Article Circ Cardiovasc Interv · June 2011 BACKGROUND: Transradial percutaneous coronary procedures may be effectively performed through the right radial approach (RRA) or the left radial approach (LRA), but data on radiation dose absorbed by operators comparing the two approaches are lacking. The ... Full text Link to item Cite

Intravenous erythropoietin in patients with ST-segment elevation myocardial infarction: REVEAL: a randomized controlled trial.

Journal Article JAMA · May 11, 2011 CONTEXT: Acute ST-segment elevation myocardial infarction (STEMI) is a leading cause of morbidity and mortality. In experimental models of MI, erythropoietin reduces infarct size and improves left ventricular (LV) function. OBJECTIVE: To evaluate the safet ... Full text Link to item Cite

Radial versus femoral access for coronary angiography and intervention in patients with acute coronary syndromes (RIVAL): a randomised, parallel group, multicentre trial.

Journal Article Lancet · April 23, 2011 Featured Publication BACKGROUND: Small trials have suggested that radial access for percutaneous coronary intervention (PCI) reduces vascular complications and bleeding compared with femoral access. We aimed to assess whether radial access was superior to femoral access in pat ... Full text Link to item Cite

Reply

Journal Article JACC: Cardiovascular Interventions · April 1, 2011 Full text Cite

Effect of concomitant use of clopidogrel and proton pump inhibitors after percutaneous coronary intervention.

Journal Article Am J Cardiol · March 15, 2011 The aim of the present study was to analyze the effect of drug exposure patterns of clopidogrel and proton pump inhibitors (PPIs) on the clinical outcomes after percutaneous coronary intervention (PCI). Previous analyses predominantly included discharge me ... Full text Link to item Cite

Transradial PCI in women: problem solved or clinical equipoise?

Journal Article J Invasive Cardiol · March 2011 Featured Publication Link to item Cite

The impact of postrandomization crossover of therapy in acute coronary syndromes care.

Journal Article Circ Cardiovasc Qual Outcomes · March 2011 BACKGROUND: In the Superior Yield of the New Strategy of Enoxaparin, Revascularization, and Glycoprotein IIb/IIIa Inhibitors (SYNERGY) study, patients assigned enoxaparin or unfractionated heparin (UFH) were treated with alternative anticoagulant therapy a ... Full text Link to item Cite

Incidence, prognostic impact, and influence of antithrombotic therapy on access and nonaccess site bleeding in percutaneous coronary intervention.

Journal Article JACC Cardiovasc Interv · February 2011 OBJECTIVES: The aim of this study was to evaluate the relative frequency of access and nonaccess site bleeding, the association of these events with 1-year mortality, and the impact of randomized antithrombotic therapy. BACKGROUND: Post-percutaneous corona ... Full text Link to item Cite

Design and rationale of the radial versus femoral access for coronary intervention (RIVAL) trial: a randomized comparison of radial versus femoral access for coronary angiography or intervention in patients with acute coronary syndromes.

Journal Article Am Heart J · February 2011 BACKGROUND: Major bleeding in acute coronary syndromes (ACS) is associated with an increased risk of subsequent mortality and recurrent ischemic events. Observational data and small randomized trials suggest that radial instead of femoral access for corona ... Full text Link to item Cite

Race, Bleeding, and Outcomes in STEMI Patients Treated with Fibrinolytic Therapy.

Journal Article Am J Med · January 2011 BACKGROUND: studies have shown higher bleeding and mortality rates among African Americans who receive fibrinolytic therapy for ST-segment elevation myocardial infarction (STEMI) compared with whites; however, the relationship of bleeding risk to mortality ... Full text Link to item Cite

Transradial PCI in women: Problem solved or clinical equipoise?

Journal Article Journal of Invasive Cardiology · January 1, 2011 Cite

Survival of patients undergoing rescue percutaneous coronary intervention: development and validation of a predictive tool.

Journal Article JACC Cardiovasc Interv · January 2011 OBJECTIVES: This study sought to develop a tool for predicting an individual's risk of mortality following rescue percutaneous coronary intervention (PCI). BACKGROUND: Although fibrinolytic therapy is appropriate and improves survival for certain ST-segmen ... Full text Link to item Cite

The evolving role of glycoprotein IIb/IIIa inhibitors in the setting of percutaneous coronary intervention strategies to minimize bleeding risk and optimize outcomes.

Journal Article JACC Cardiovasc Interv · December 2010 The use of glycoprotein IIb/IIIa inhibitors (GPI) reduces ischemic events in patients undergoing percutaneous coronary intervention (PCI). However, the same properties that confer this benefit lead to an increased bleeding risk. Recent studies have shown a ... Full text Link to item Cite

Patterns of discharge antiplatelet therapy and late outcomes among 8,582 patients with bleeding during acute coronary syndrome: a pooled analysis from PURSUIT, PARAGON-A, PARAGON-B, and SYNERGY.

Journal Article Am Heart J · December 2010 BACKGROUND: Major bleeding during an acute coronary syndrome (ACS) is associated with increased late ischemic events. Patients with bleeding are often discharged without antiplatelet therapy (AT). The association between discharge AT use and late ischemic ... Full text Link to item Cite

Fondaparinux with UnfracTionated heparin dUring Revascularization in Acute coronary syndromes (FUTURA/OASIS 8): a randomized trial of intravenous unfractionated heparin during percutaneous coronary intervention in patients with non-ST-segment elevation acute coronary syndromes initially treated with fondaparinux.

Journal Article Am Heart J · December 2010 BACKGROUND: There is uncertainty regarding the optimal adjunctive unfractionated heparin (UFH) regimen for percutaneous coronary intervention (PCI) in patients with non-ST-segment elevation acute coronary syndrome (NSTE-ACS) treated with fondaparinux. OBJE ... Full text Link to item Cite

Bivalirudin: a review of the pharmacology and clinical application.

Journal Article Expert Rev Cardiovasc Ther · December 2010 Among the current agents in the class of direct thrombin inhibitors, bivalirudin (Angiomax(®), The Medicines Company, NJ, USA) has seen increased use in cardiovascular medicine over the past decade through its primary indication as an anticoagulant used du ... Full text Link to item Cite

Design and rationale of the Reduction of Infarct Expansion and Ventricular Remodeling with Erythropoietin after Large Myocardial Infarction (REVEAL) trial.

Journal Article Am Heart J · November 2010 BACKGROUND: Acute myocardial infarction (MI) remains a leading cause of death despite advances in pharmacologic and percutaneous therapies. Animal models of ischemia/reperfusion have demonstrated that single-dose erythropoietin may reduce infarct size, dec ... Full text Link to item Cite

Reply

Journal Article Journal of the American College of Cardiology · October 5, 2010 Full text Cite

Bleeding associated with current therapies for acute coronary syndrome: what are the mechanisms?

Journal Article J Thromb Thrombolysis · October 2010 Coronary artery plaque rupture results in platelet adhesion and activation, the release of adenosine diphosphate (ADP), thromboxane A(2), and the generation of thrombin. These factors propagate further platelet activation through a positive feedback mechan ... Full text Link to item Cite

Transradial approach for coronary angiography and interventions: results of the first international transradial practice survey.

Journal Article JACC Cardiovasc Interv · October 2010 OBJECTIVES: The aim of this study was to evaluate practice of transradial approach (TRA). BACKGROUND: TRA has been adopted as an alternative access site for coronary procedures. METHODS: A questionnaire was distributed worldwide with Internet-based softwar ... Full text Link to item Cite

Frequency and predictors of drug-eluting stent use in saphenous vein bypass graft percutaneous coronary interventions: a report from the American College of Cardiology National Cardiovascular Data CathPCI registry.

Journal Article JACC Cardiovasc Interv · October 2010 OBJECTIVES: We examined a large registry to determine the frequency and factors associated with drug-eluting stents (DES) use in saphenous vein graft (SVG) in contemporary practice. BACKGROUND: Prospective trials comparing DES with bare-metal stents in SVG ... Full text Link to item Cite

Rapid adoption of drug-eluting stents: clinical practices and outcomes from the early drug-eluting stent era.

Journal Article Am Heart J · October 2010 OBJECTIVES: We sought to evaluate the early drug-eluting stent (DES) era, characterized by widespread device use. BACKGROUND: Contemporary clinical practice incorporating more selective DES use can only be assessed by understanding the early DES era. METHO ... Full text Link to item Cite

Relationship between renal function and outcomes in high-risk patients with non-ST-segment elevation acute coronary syndromes: results from SYNERGY.

Journal Article Int J Cardiol · September 24, 2010 BACKGROUND: Chronic kidney disease (CKD) is a risk factor for coronary heart disease and bleeding with antithrombotic therapy in patients with acute coronary syndromes (ACS). We evaluated the effect of renal function on efficacy and outcomes in high-risk p ... Full text Link to item Cite

Low-dose vs standard-dose unfractionated heparin for percutaneous coronary intervention in acute coronary syndromes treated with fondaparinux: the FUTURA/OASIS-8 randomized trial.

Journal Article JAMA · September 22, 2010 CONTEXT: The optimal unfractionated heparin regimen for percutaneous coronary intervention (PCI) in patients with non-ST-segment elevation acute coronary syndromes treated with fondaparinux is uncertain. OBJECTIVE: To compare the safety of 2 unfractionated ... Full text Link to item Cite

Acceptance, panic, and partial recovery the pattern of usage of drug-eluting stents after introduction in the U.S. (a report from the American College of Cardiology/National Cardiovascular Data Registry).

Journal Article JACC Cardiovasc Interv · September 2010 OBJECTIVES: Review the use of drug-eluting stents (DES) to evaluate changes in use. BACKGROUND: The DES were approved after several small studies in carefully selected patients showed dramatic reduction in in-stent restenosis. The DES were then rapidly ado ... Full text Link to item Cite

Impact of changes in clinical practice guidelines on assessment of quality of care.

Journal Article Med Care · August 2010 BACKGROUND: Measures for pay-for-performance and public reporting programs may be based on clinical practice guidelines. The impact of guideline changes over time-and whether evolving clinical evidence can render measures based on prior guidelines misleadi ... Full text Link to item Cite

Cost-effectiveness of targeting patients undergoing percutaneous coronary intervention for therapy with bivalirudin versus heparin monotherapy according to predicted risk of bleeding.

Journal Article Circ Cardiovasc Qual Outcomes · July 2010 BACKGROUND: Although bivalirudin compared with unfractionated heparin with glycoprotein IIb/IIIa inhibitors reduces bleeding and hospitalization costs in patients undergoing percutaneous coronary intervention (PCI), little is known about the economic impac ... Full text Link to item Cite

Elinogrel: pharmacological principles, preclinical and early phase clinical testing.

Journal Article Future Cardiol · July 2010 Antiplatelet drug therapy represents the cornerstone of treatment for cardiovascular atherothrombotic disease processes. Dual antiplatelet therapy with aspirin and oral ADP-receptor antagonists such as clopidogrel are currently the standard care for preven ... Full text Link to item Cite

Rationale and design of the randomized, double-blind trial testing INtraveNous and Oral administration of elinogrel, a selective and reversible P2Y(12)-receptor inhibitor, versus clopidogrel to eVAluate Tolerability and Efficacy in nonurgent Percutaneous Coronary Interventions patients (INNOVATE-PCI).

Journal Article Am Heart J · July 2010 Despite current dual-antiplatelet therapy with aspirin and clopidogrel, adverse clinical events continue to occur during and after percutaneous coronary intervention (PCI). The failure of clopidogrel to provide optimal protection may be related to delayed ... Full text Link to item Cite

Association between use of bleeding avoidance strategies and risk of periprocedural bleeding among patients undergoing percutaneous coronary intervention.

Journal Article JAMA · June 2, 2010 CONTEXT: Bleeding complications with percutaneous coronary intervention (PCI) are associated with adverse patient outcomes. The association between the use of bleeding avoidance strategies and post-PCI bleeding as a function of a patient's preprocedural ri ... Full text Link to item Cite

Incidence, outcomes, and management of bleeding in non-ST-elevation acute coronary syndromes.

Journal Article Cleve Clin J Med · June 2010 Antithrombotic and antiplatelet drugs and percutaneous interventions have decreased the ischemic outcomes of non-ST-elevation acute coronary syndromes, but they pose risks of bleeding. The authors review the scope of the problem and ways to prevent and man ... Full text Link to item Cite

Economic assessment of thrombocytopenia: CATCH Registry.

Journal Article J Med Syst · June 2010 Thrombocytopenia is associated with increased patient risk. However, the costs of this complication are not well defined. This study assessed the impact of thrombocytopenia on in-hospital costs using results from CATCH, an observational study that examined ... Full text Link to item Cite

The impact of bivalirudin on percutaneous coronary intervention-related bleeding.

Journal Article EuroIntervention · June 2010 AIMS: We studied the clinical and economic impact of bivalirudin in clinical practice. METHODS AND RESULTS: Consecutive patients undergoing PCI via the common femoral artery for stable, unstable, or atypical angina, silent ischaemia, or non-ST-elevation my ... Link to item Cite

The transradial approach to percutaneous coronary intervention: historical perspective, current concepts, and future directions.

Journal Article J Am Coll Cardiol · May 18, 2010 Featured Publication Periprocedural bleeding complications after percutaneous coronary intervention (PCI) are associated with increased short- and long-term morbidity and mortality. Although clinical trials have primarily assessed pharmacological strategies for reducing bleedi ... Full text Link to item Cite

Contemporary mortality risk prediction for percutaneous coronary intervention: results from 588,398 procedures in the National Cardiovascular Data Registry.

Journal Article J Am Coll Cardiol · May 4, 2010 OBJECTIVES: We sought to create contemporary models for predicting mortality risk following percutaneous coronary intervention (PCI). BACKGROUND: There is a need to identify PCI risk factors and accurately quantify procedural risks to facilitate comparativ ... Full text Link to item Cite

Is old blood bad blood?

Journal Article Am Heart J · May 2010 Full text Link to item Cite

Evaluation of a new heparin agent in percutaneous coronary intervention: results of the phase 2 evaluation of M118 IN pErcutaNeous Coronary intErvention (EMINENCE) Trial.

Journal Article Circulation · April 20, 2010 Featured Publication BACKGROUND: Factor Xa and factor IIa (thrombin) play roles in thrombotic complications after percutaneous coronary intervention. M118 is a novel low-molecular-weight heparin that has been rationally designed to capture the desired attributes of unfractiona ... Full text Link to item Cite

Incidence, predictors, and prognostic implications of hospitalization for late bleeding after percutaneous coronary intervention for patients older than 65 years.

Journal Article Circ Cardiovasc Interv · April 2010 BACKGROUND: Previous data on bleeding after percutaneous coronary intervention (PCI) have been obtained primarily from randomized trials that focused on in-hospital bleeding. The incidence of late bleeding after PCI, its independent predictors, and its pro ... Full text Link to item Cite

Anticoagulant therapy for percutaneous coronary intervention.

Journal Article Circ Cardiovasc Interv · February 1, 2010 Full text Link to item Cite

Correlation of inhibition of platelet aggregation after clopidogrel with post discharge bleeding events: assessment by different bleeding classifications.

Journal Article Eur Heart J · January 2010 AIMS: To correlate inhibition of platelet aggregation (IPA) with bleeding events assessed by TIMI, GUSTO, and BleedScore scales in a large cohort of patients with coronary artery disease (CAD) and ischaemic stroke (IS) treated with chronic low-dose aspirin ... Full text Link to item Cite

Management of platelet-directed pharmacotherapy in patients with atherosclerotic coronary artery disease undergoing elective endoscopic gastrointestinal procedures.

Journal Article J Am Coll Cardiol · December 8, 2009 The periprocedural management of patients with atherosclerotic coronary heart disease, including those who have heart disease and those who are undergoing percutaneous coronary intervention and stent placement who might require temporary interruption of pl ... Full text Link to item Cite

Standardized reporting of bleeding complications for clinical investigations in acute coronary syndromes: a proposal from the academic bleeding consensus (ABC) multidisciplinary working group.

Journal Article Am Heart J · December 2009 Featured Publication BACKGROUND: Clinical trials of antithrombotic agents for the treatment of ACS routinely assess bleeding as a safety endpoint, but variation in bleeding definitions makes comparison of the relative safety of these agents difficult. METHODS: The ABC Multidis ... Full text Link to item Cite

Management of platelet-directed pharmacotherapy in patients with atherosclerotic coronary artery disease undergoing elective endoscopic gastrointestinal procedures.

Journal Article Am J Gastroenterol · December 2009 The periprocedural management of patients with atherosclerotic coronary heart disease, including those who have heart disease and those who are undergoing percutaneous coronary intervention and stent placement who might require temporary interruption of pl ... Full text Link to item Cite

Design and rationale of the Evaluation of M118 IN pErcutaNeous Coronary intErvention (EMINENCE) trial.

Journal Article Am Heart J · November 2009 BACKGROUND: Currently recommended anticoagulant agents used in the setting of percutaneous coronary intervention (PCI) inhibit, with varying degrees of intensity, 2 critical targets (factor Xa and/or IIa) of the coagulation cascade, yet they carry signific ... Full text Link to item Cite

Aldehyde dehydrogenase activity allows reliable EPC enumeration in stored peripheral blood samples.

Journal Article J Thromb Thrombolysis · October 2009 BACKGROUND: Interest in the biology of endogenous progenitor cells (EPCs) continues to grow as evidence of their role in vascular repair mounts. EPC enumeration requires specialized laboratory techniques and is performed immediately after sample acquisitio ... Full text Link to item Cite

Strategies to reduce bleeding among patients with ischemic heart disease treated with antiplatelet therapies.

Journal Article Am J Cardiol · September 7, 2009 Antiplatelet therapy is the cornerstone of management in acute coronary syndromes (ACS) and percutaneous coronary intervention. Combination therapy with aspirin and clopidogrel reduces the risk of death, myocardial infarction, or stroke in ACS but increase ... Full text Link to item Cite

Temporal changes in the use of drug-eluting stents for patients with non-ST-Segment-elevation myocardial infarction undergoing percutaneous coronary intervention from 2006 to 2008: results from the can rapid risk stratification of unstable angina patients supress ADverse outcomes with early implementation of the ACC/AHA guidelines (CRUSADE) and acute coronary treatment and intervention outcomes network-get with the guidelines (ACTION-GWTG) registries.

Journal Article Circ Cardiovasc Qual Outcomes · September 2009 BACKGROUND: The risks of late stent thrombosis with drug-eluting stents (DES) were intensely debated after the presentation of a number of studies highlighting this issue in September 2006. We evaluated trends in the use of DES for patients with non-ST-ele ... Full text Link to item Cite

Prevalence, predictors, and in-hospital outcomes of non-infarct artery intervention during primary percutaneous coronary intervention for ST-segment elevation myocardial infarction (from the National Cardiovascular Data Registry).

Journal Article Am J Cardiol · August 15, 2009 Guidelines support percutaneous coronary intervention (PCI) of the noninfarct-related artery during primary PCI for ST-segment elevation myocardial infarction (STEMI) in patients with hemodynamic compromise; however, in patients without hemodynamic comprom ... Full text Link to item Cite

The association between the transradial approach for percutaneous coronary interventions and bleeding

Journal Article Journal of Invasive Cardiology · August 1, 2009 Bleeding complications after percutaneous coronary interventions (PCI) are a significant clinical problem associated with worse patient outcomes, including mortality. A number of studies have demonstrated that the majority of bleeding complications in pati ... Cite

The association between the transradial approach for percutaneous coronary interventions and bleeding.

Journal Article J Invasive Cardiol · August 2009 Bleeding complications after percutaneous coronary interventions (PCI) are a significant clinical problem associated with worse patient outcomes, including mortality. A number of studies have demonstrated that the majority of bleeding complications in pati ... Link to item Cite

Bleeding in patients undergoing percutaneous coronary intervention: the development of a clinical risk algorithm from the National Cardiovascular Data Registry.

Journal Article Circ Cardiovasc Interv · June 2009 BACKGROUND: Bleeding in patients undergoing percutaneous coronary intervention (PCI) is associated with increased morbidity, mortality, length of hospitalization, and cost. We identified baseline clinical characteristics associated with bleeding complicati ... Full text Link to item Cite

Baseline risk of major bleeding in non-ST-segment-elevation myocardial infarction: the CRUSADE (Can Rapid risk stratification of Unstable angina patients Suppress ADverse outcomes with Early implementation of the ACC/AHA Guidelines) Bleeding Score.

Journal Article Circulation · April 14, 2009 BACKGROUND: Treatments for non-ST-segment-elevation myocardial infarction (NSTEMI) reduce ischemic events but increase bleeding. Baseline prediction of bleeding risk can complement ischemic risk prediction for optimization of NSTEMI care; however, existing ... Full text Link to item Cite

Clinical and angiographic outcomes with sirolimus-eluting stents in total coronary occlusions: the ACROSS/TOSCA-4 (Approaches to Chronic Occlusions With Sirolimus-Eluting Stents/Total Occlusion Study of Coronary Arteries-4) trial.

Journal Article JACC Cardiovasc Interv · February 2009 OBJECTIVES: We sought to examine angiographic and clinical outcomes with sirolimus-eluting stents (SES) in total coronary occlusion (TCO) revascularization. BACKGROUND: Despite evaluation of drug-eluting stents beyond approved indications, few studies have ... Full text Link to item Cite

Consequences of major bleeding in hospitalized patients with non-ST segment elevation acute coronary syndromes receiving injectable anticoagulants.

Journal Article Curr Med Res Opin · February 2009 OBJECTIVE: To evaluate the burden of major bleed in patients with non-ST segment elevation acute coronary syndromes (NSTE ACS) receiving injectable anticoagulation from the hospital perspective. METHODS: Retrospective analysis of inpatient medical and phar ... Full text Link to item Cite

The role of out-of-hospital cardiac arrest in predicting hospital mortality for percutaneous coronary interventions in the Clinical Outcomes Assessment Program.

Journal Article J Invasive Cardiol · January 2009 Published mortality models for percutaneous coronary intervention (PCI), including the Clinical Outcomes Assessment Program (COAP) model, have not considered the effect of out-ofhospital cardiac arrest. The primary objective of this study was to determine ... Link to item Cite

Bleeding after antithrombotic therapy in patients with acute ischemic heart disease: is it the drugs or how we use them?

Journal Article J Thromb Thrombolysis · December 2008 Definitions of bleeding must be considered when evaluating results of clinical trials. Assessments of bleeding impact based on clinical criteria may be more relevant to patient outcomes than those based on simple laboratory measures like an isolated change ... Full text Link to item Cite

Bleeding and transfusion in the setting of ACS

Journal Article Acute Coronary Syndromes · December 1, 2008 Anticoagulant and antiplatelet therapies are cornerstones in the management of ACS, yet each of these therapies is associated with an increased risk of bleeding. A number of analyses suggest that both bleeding events in the setting of ACS and the transfusi ... Cite

Antiplatelet therapy use after discharge among acute myocardial infarction patients with in-hospital bleeding.

Journal Article Circulation · November 18, 2008 BACKGROUND: Bleeding among patients with acute myocardial infarction (AMI) is associated with worse long-term outcomes. Although the mechanism underlying this association is unclear, a potential explanation is that withholding antiplatelet therapies long b ... Full text Link to item Cite

Clopidogrel use and bleeding after coronary artery bypass graft surgery.

Journal Article Am Heart J · November 2008 BACKGROUND: Short-term use of clopidogrel plus aspirin among patients with acute coronary syndrome reduces ischemic events, but concerns about coronary artery bypass graft (CABG) surgery-related bleeding limit its early use. METHODS: Using data from 4,794 ... Full text Link to item Cite

Comparison of the impact of short (<1 year) and long-term (> or =1 year) clopidogrel use following percutaneous coronary intervention on mortality.

Journal Article Am J Cardiol · November 1, 2008 The optimal duration of clopidogrel administration after percutaneous coronary intervention (PCI) remains unknown. Clopidogrel is currently recommended for minimums of 1 and 12 months after bare-metal stent and drug-eluting stent implantation, respectively ... Full text Link to item Cite

Informing the consent process.

Journal Article Circ Cardiovasc Qual Outcomes · September 2008 Full text Link to item Cite

Long-term clinical outcomes following coronary stenting.

Journal Article Arch Intern Med · August 11, 2008 BACKGROUND: Clinical trials of drug-eluting stents (DES) vs bare metal stents (BMS) report a reduced need for target lesion revascularization with no difference in death or myocardial infarction. However, these trials selectively enrolled patients with low ... Full text Link to item Cite

Postmarket evaluation of breakthrough technologies.

Journal Article Am Heart J · August 2008 Cardiovascular procedures performed in the United States have more than tripled in the last decade, a trend that is expected to continue with the aging of the population, coupled with epidemics of obesity and diabetes mellitus. Helping to drive this increa ... Full text Link to item Cite

Trends in the prevalence and outcomes of radial and femoral approaches to percutaneous coronary intervention: a report from the National Cardiovascular Data Registry.

Journal Article JACC Cardiovasc Interv · August 2008 Featured Publication OBJECTIVES: Our goal was to compare trends in the prevalence and outcomes of the radial and femoral approaches to percutaneous coronary intervention (PCI) in contemporary clinical practice. BACKGROUND: There are few current data on the use and outcomes of ... Full text Link to item Cite

Major bleeding: management and risk reduction in acute coronary syndromes.

Journal Article Expert Opin Pharmacother · August 2008 BACKGROUND: Guidelines for the management of high-risk non ST-segment elevation acute coronary syndrome (NSTE ACS) recommend antithrombotic and antiplatelet therapy combined with an early invasive strategy. While this strategy reduces ischemic complication ... Full text Link to item Cite

Transfusion practice and outcomes in non-ST-segment elevation acute coronary syndromes.

Journal Article Am Heart J · June 2008 OBJECTIVES: To describe the association between transfusion and outcomes as a function of nadir hematocrit (HCT) in patients with non-ST-segment elevation acute coronary syndromes (NSTE ACS). BACKGROUND: The adverse outcomes associated with transfusion in ... Full text Link to item Cite

Platelets: developmental biology, physiology, and translatable platforms for preclinical investigation and drug development.

Journal Article Platelets · June 2008 This paper, developed from the proceedings of the 2007 Platelet Colloquium, considers emerging constructs in platelet biology, preclinical models of thrombosis, and their potential application to the development of platelet-directed pharmacotherapies. Disc ... Full text Link to item Cite

Variation in the use of stress testing and outcomes in patients with non-ST-elevation acute coronary syndromes: insights from GUSTO IIb.

Journal Article Eur Heart J · April 2008 AIMS: Non-invasive risk stratification of low- and intermediate-risk non-ST-elevation acute coronary syndromes (NSTE ACS) patients has been recommended, but limited data exist about the variation in clinical practice of stress testing in these patients and ... Full text Link to item Cite

Bleeding and ischemic events run parallel in NSTEMI patients

Conference JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY · March 11, 2008 Link to item Cite

Association between bleeding, blood transfusion, and costs among patients with non-ST-segment elevation acute coronary syndromes.

Journal Article Am Heart J · February 2008 BACKGROUND: Bleeding and blood transfusion are associated with increased morbidity and mortality among patients with non-ST-segment elevation acute coronary syndromes (NSTE ACS); however, the economic consequences of these complications are not well define ... Full text Link to item Cite

International variation in the use of blood transfusion in patients with non-ST-segment elevation acute coronary syndromes.

Journal Article Am J Cardiol · January 1, 2008 The purpose of this study was to determine international patterns of blood transfusion in patients with acute coronary syndrome (ACS). Previous studies showed geographic heterogeneity in some aspects of ACS care. Data for variability in the use of blood tr ... Full text Link to item Cite

Pharmacoinvasive management of acute coronary syndrome: incorporating the 2007 ACC/AHA guidelines: the CATH (cardiac catheterization and antithrombotic therapy in the hospital) Clinical Consensus Panel Report--III.

Journal Article J Invasive Cardiol · December 2007 This paper provides a comprehensive up-to-date review of the medical and invasive management of patients with non-ST-segment elevation acute coronary syndromes (NSTE-ACS), and ST-elevation myocardial infarction (STEMI), as supported by recent updates to th ... Link to item Cite

The challenge of defining bleeding among patients with acute coronary syndromes.

Journal Article Clin Cardiol · October 2007 Advances in the management of patients with acute coronary syndromes (ACS), specifically, the use of combined pharmacotherapy with antithrombotic and antiplatelet therapies and routine percutaneous coronary intervention (PCI), have greatly reduced rates of ... Full text Link to item Cite

Bleeding and blood transfusion issues in patients with non-ST-segment elevation acute coronary syndromes.

Journal Article Eur Heart J · May 2007 Featured Publication Antithrombotic therapy and invasive risk stratification in selected high-risk patients have improved outcomes from non-ST-segment elevation acute coronary syndromes (NSTE-ACS), but carry a risk of bleeding and blood transfusion. Although the true incidence ... Full text Link to item Cite

REPAIR-AMI: stem cells for acute myocardial infarction.

Journal Article Future Cardiol · March 2007 Evaluation of: Schachinger V, Erbs S, Elsasser A et al.: Intracoronary bone marrow-derived progenitor cells in acute myocardial infarction. N. Engl. J. Med. 355, 1210-1221 (2006). The Reinfusion of Enriched Progenitor cells And Infarct Remodeling in Acute ... Full text Link to item Cite

Implications of bleeding and blood transfusion in percutaneous coronary intervention.

Journal Article Rev Cardiovasc Med · 2007 For patients undergoing percutaneous coronary intervention (PCI), bleeding complications are a major clinical concern. With advances in pharmacotherapy and devices over the past 2 decades, the risk of ischemic outcomes, such as myocardial infarction or dea ... Link to item Cite

Anemia in patients undergoing percutaneous coronary intervention: current issues and future directions.

Journal Article Am J Cardiovasc Drugs · 2007 Anemia is common among patients with coronary artery disease (CAD) and portends a higher risk of short- and long-term mortality, major adverse cardiac events, and bleeding complications. Blood transfusion has long been the cornerstone of therapy for anemia ... Full text Link to item Cite

Strategies for optimizing outcomes in the NSTE-ACS patient The CATH (cardiac catheterization and antithrombotic therapy in the hospital) Clinical Consensus Panel Report.

Journal Article J Invasive Cardiol · December 2006 This paper provides a comprehensive up-to-date review of the medical and invasive management of patients with non- ST-segment elevation acute coronary syndromes (NSTE-ACS). The authors have summarized findings from key clinical trials published recent year ... Link to item Cite

Clinical outcomes with drug-eluting stents following atheroablation therapies.

Journal Article J Invasive Cardiol · September 2006 BACKGROUND: Prior studies of atheroablation (directional atherectomy, rotational atherectomy and laser angioplasty) have demonstrated either no advantage or worse outcomes relative to conventional balloon angioplasty. Because these techniques are still req ... Link to item Cite

Patterns and outcomes of drug-eluting coronary stent use in clinical practice.

Journal Article Am Heart J · August 2006 OBJECTIVE: To determine patterns and outcomes of drug-eluting stents (DES) use in clinical practice. BACKGROUND: DES are technology associated with superior outcomes. The initial limited availability and high cost of DES had the potential to influence thei ... Full text Link to item Cite

On- versus off-label use of drug-eluting coronary stents in clinical practice (report from the American College of Cardiology National Cardiovascular Data Registry [NCDR]).

Journal Article Am J Cardiol · May 15, 2006 Limited data are available on the off-label use of drug-eluting stents (DESs) in clinical practice. We used data from the American College of Cardiology National Cardiovascular Data Registry to describe the rates and outcomes of DES use in 4 common off-lab ... Full text Link to item Cite

Proinflammatory, immunomodulating, and prothrombotic properties of anemia and red blood cell transfusions.

Journal Article J Thromb Thrombolysis · April 2006 For many years, the traditional treatment for hospitalized patients in the United States who have developed anemia, whether associated with medical illness, surgical procedures or trauma, has been red blood cell transfusion, despite the absence of supporti ... Full text Link to item Cite

A comparison of the clinical impact of bleeding measured by two different classifications among patients with acute coronary syndromes.

Journal Article J Am Coll Cardiol · February 21, 2006 OBJECTIVES: The goal of this study was to determine the association between Thrombolysis In Myocardial Infarction (TIMI) and Global Use of Strategies to Open Occluded Coronary Arteries (GUSTO) bleeding and clinical outcomes. BACKGROUND: There are limited d ... Full text Link to item Cite

Bleeding as a predictor of mortality risk.

Journal Article Rev Cardiovasc Med · 2006 The increased rate of bleeding during and after cardiac procedures is a concern. The best strategy is prevention of bleeding complications with anticoagulant therapy that provides an adequate anti-thrombotic effect while reducing bleeding. The independent ... Link to item Cite

Impact of bleeding severity on clinical outcomes among patients with acute coronary syndromes.

Journal Article Am J Cardiol · November 1, 2005 Bleeding is a complication of current therapies for acute coronary syndrome (ACS). No studies have examined the effect of bleeding events on clinical outcomes. We analyzed pooled data from 4 multicenter, randomized clinical trials of patients who had ACS ( ... Full text Link to item Cite

The implications of blood transfusions for patients with non-ST-segment elevation acute coronary syndromes: results from the CRUSADE National Quality Improvement Initiative.

Journal Article J Am Coll Cardiol · October 18, 2005 OBJECTIVES: In a large contemporary population of patients with non-ST-segment elevation acute coronary syndromes (NSTE ACS), we sought to describe blood transfusion rates (overall and in patients who did not undergo coronary artery bypass grafting [CABG]) ... Full text Link to item Cite

Evidence-based therapies and mortality in patients hospitalized in December with acute myocardial infarction.

Journal Article Ann Intern Med · October 4, 2005 BACKGROUND: Previous studies suggest that patients hospitalized with acute myocardial infarction (MI) in December have poor outcomes, and some studies have hypothesized that the cause may be the infrequent use of evidence-based therapies during the Decembe ... Full text Link to item Cite

Device therapy in the management of congestive heart failure.

Journal Article Cardiol Rev · 2005 Despite significant advancements in the treatment of heart failure over the past 2 decades, this patient population is still subject to considerably high morbidity and mortality rates. In recent years, the field of device therapy as adjunctive treatment to ... Full text Link to item Cite

Relationship of blood transfusion and clinical outcomes in patients with acute coronary syndromes.

Journal Article JAMA · October 6, 2004 Featured Publication CONTEXT: It is unclear if blood transfusion in anemic patients with acute coronary syndromes is associated with improved survival. OBJECTIVE: To determine the association between blood transfusion and mortality among patients with acute coronary syndromes ... Full text Link to item Cite

Association of race with complications and prognosis following acute coronary syndromes.

Journal Article Am J Cardiol · September 15, 2004 The baseline characteristics, complications, and survival of 489 black and 6,890 non-black patients with acute coronary syndromes were studied. Important racial differences were observed in demographic features, atherosclerosis risk factors, and treatment ... Full text Link to item Cite

State-mandated continuing medical education and the use of proven therapies in patients with an acute myocardial infarction.

Journal Article J Am Coll Cardiol · July 7, 2004 OBJECTIVES: The purpose of this study was to determine whether state-mandated continuing medical education (CME) requirements affect the use of evidence-based therapies and outcomes in patients with acute myocardial infarction (AMI). BACKGROUND: The Instit ... Full text Link to item Cite

Socioeconomic status and outcome following acute myocardial infarction in elderly patients.

Journal Article Arch Intern Med · May 24, 2004 BACKGROUND: Although the Medicare entitlement provides universal hospital care coverage for elderly Americans, disparities in care processes after acute myocardial infarction still exist. Whether these disparities account for increased mortality among elde ... Full text Link to item Cite

Large scale association analysis for identification of genes underlying premature coronary heart disease: cumulative perspective from analysis of 111 candidate genes.

Journal Article J Med Genet · May 2004 BACKGROUND: to date, only three groups have reported data from large scale genetic association studies of coronary heart disease using a case control design. METHODS AND RESULTS: to extend our initial report of 62 genes, we present data for 210 polymorphis ... Full text Link to item Cite

Quality of Coronary Disease Report Cards

Chapter · January 1, 2004 Over the past two decades, there have been numerous approaches to lowering cost in the United States health care system including capitated insurance, contracting for services by large purchasers, prospective hospital and outpatient reimbursement, and Medi ... Full text Cite

Controversies surrounding the use of glycoprotein IIb/IIIa inhibitors.

Journal Article Crit Pathw Cardiol · December 2003 The use of glycoprotein IIb/IIIa inhibitors reduces morbidity and mortality in patients with acute coronary syndromes and patients undergoing percutaneous coronary intervention. Despite the sound body of evidence that supports the use of these agents, regi ... Full text Link to item Cite

Management of glomerular proteinuria: a commentary.

Journal Article J Am Soc Nephrol · December 2003 It is widely accepted that proteinuria reduction is an appropriate therapeutic goal in chronic proteinuric kidney disease. Based on large randomized controlled clinical trials (RCT), ACE inhibitor (ACEI) and angiotensin receptor blocker (ARB) therapy have ... Full text Link to item Cite

Poverty, process of care, and outcome in acute coronary syndromes.

Journal Article J Am Coll Cardiol · June 4, 2003 OBJECTIVES: We sought to determine whether income-based disparities in care processes and outcome exist in patients with acute coronary syndromes. BACKGROUND: Using income proxies and limited clinical data, some observational studies have shown income disp ... Full text Link to item Cite

Prognostic value of isolated troponin elevation across the spectrum of chest pain syndromes.

Journal Article Am J Cardiol · April 15, 2003 The risk of death or recurrent myocardial infarction (MI) in patients with chest pain and baseline isolated troponin elevation is unclear. To determine the early and short-term risk of death or MI associated with isolated troponin elevation across a spectr ... Full text Link to item Cite

Assessing quality in the cardiac catheterization laboratory.

Journal Article Am Heart Hosp J · 2003 Quality assurance and improvement have increasingly been the focus of health care providers, third-party payers, and patients. Because cardiovascular procedures are common, easily identifiable with claims data, and account for a relatively large proportion ... Full text Link to item Cite

Quality of care in percutaneous coronary intervention

Journal Article Cardiovascular Reviews and Reports · January 1, 2002 The assessment of quality is gaining more importance as physicians and hospitals are expected to adhere to standards of quality care. Cardiovascular procedures, such as percutaneous coronary intervention (PCI), lend themselves to quality assessment because ... Cite

Influence of poverty on process of care and outcome in acute coronary syndromes

Journal Article JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY · 2002 Cite