Scholars@Duke
Laura Pat Svetkey

Laura Pat Svetkey

Professor Emeritus of Medicine
Medicine, Nephrology
svetk001@mc.duke.edu
Box, Durham, NC 27710
454 Davison Bldg - Room 452D, Duke Hospital South, Durham, NC 27710

Selected Publications

Effects of a Digital Intervention to Improve DASH and Blood Pressure Among US Adults.

Journal Article Hypertension · February 2025 BACKGROUND: Dietary Approaches to Stop Hypertension (DASH) is a recommended first-line treatment for adults with hypertension, yet adherence to DASH is low. To evaluate the efficacy of a digital health intervention (DHI), compared with attention control, o ... Full text Link to item Cite

Sociodemographic predictors of successful screening and subsequent randomization in a digital health hypertension intervention.

Journal Article Digit Health · 2024 INTRODUCTION: Clinical trials often enroll nonrepresentative participant samples, limiting generalizability of trial findings. The current analysis explores the influences of remote recruitment and screening protocols on participation in a digital health i ... Full text Link to item Cite

Safety and Efficacy of Renal Denervation in Patients Taking Antihypertensive Medications.

Journal Article J Am Coll Cardiol · November 7, 2023 BACKGROUND: Renal denervation (RDN) reduces blood pressure (BP) in patients with uncontrolled hypertension in the absence of antihypertensive medications. OBJECTIVES: This trial assessed the safety and efficacy of RDN in the presence of antihypertensive me ... Full text Link to item Cite

Implementation of an At-home Blood Pressure Measurement Protocol in a Hypertension Management Clinical Trial During the COVID-19 Pandemic.

Journal Article J Cardiovasc Nurs · September 2022 BACKGROUND: The Dietary Approaches to Stop Hypertension eating plan is an evidence-based treatment of hypertension; however, adherence to the Dietary Approaches to Stop Hypertension is low. To improve adherence to the Dietary Approaches to Stop Hypertensio ... Full text Link to item Cite

Underutilization of Guideline-based Abdominal Aortic Aneurysm Screening in an Academic Health System.

Conference Ann Vasc Surg · July 2022 OBJECTIVES: The US Preventive Services Task Force (USPSTF) recommends a 1 time screening for AAA with ultrasonography in men aged 65-75 who have ever smoked. Our objectives were to identify the AAA screening rates in a large academic health system and asse ... Full text Link to item Cite

Facility-Level Factors and Racial Disparities in Cardiopulmonary Resuscitation within US Dialysis Clinics.

Journal Article Kidney360 · June 30, 2022 BACKGROUND: Cardiac arrest occurs frequently in outpatient dialysis clinics, and immediate cardiopulmonary resuscitation (CPR) provision improves patient outcomes. However, Black patients in dialysis clinics receive CPR from clinic staff less often compare ... Full text Link to item Cite

Racial differences in patient perception of interactions with providers are associated with health outcomes in type II diabetes.

Journal Article Patient Educ Couns · August 2021 OBJECTIVES: Examine the association of patient perceptions of care with hemoglobin A1c (HbA1c), medication adherence, and missed appointments in non-Hispanic Black (NHB) and White (NHW) patients with type 2 diabetes (T2DM). METHODS: We used linear and logi ... Full text Link to item Cite

Effect of Bicarbonate on Net Acid Excretion, Blood Pressure, and Metabolism in Patients With and Without CKD: The Acid Base Compensation in CKD Study.

Journal Article Am J Kidney Dis · July 2021 RATIONALE & OBJECTIVE: Patients with CKD are at elevated risk of metabolic acidosis due to impaired net acid excretion (NAE). Identifying early markers of acidosis may guide prevention in chronic kidney disease (CKD). This study compared NAE in participant ... Full text Link to item Cite

Diversifying the Research Workforce as a Programmatic Priority for a Career Development Award Program at Duke University.

Journal Article Acad Med · June 1, 2021 The National Institutes of Health (NIH) has prioritized efforts to increase diversity in the biomedical research workforce. NIH-funded institutional career development awards may serve as one mechanism to facilitate these efforts. In 2013, the Duke Univers ... Full text Link to item Cite

Metabolomic profiling identifies complex lipid species and amino acid analogues associated with response to weight loss interventions.

Journal Article PLoS One · 2021 Obesity is an epidemic internationally. While weight loss interventions are efficacious, they are compounded by heterogeneity with regards to clinically relevant metabolic responses. Thus, we sought to identify metabolic biomarkers that are associated with ... Full text Link to item Cite

The Patient's Point of View: Characterizing Patient-Level Factors Associated with Perceptions of Health Care.

Journal Article Health Equity · 2021 Purpose: We explored the association between perception of care, as measured by the Interpersonal Processes of Care (IPC) survey, and patient-level factors, including (1) Trust in physicians; (2) Perceived empathy; (3) Stereotype threat; (4) Perceived ever ... Full text Link to item Cite

Association of Provider Perspectives on Race and Racial Health Care Disparities with Patient Perceptions of Care and Health Outcomes.

Journal Article Health Equity · 2021 Purpose: Research suggests that providers contribute to racial disparities in health outcomes. Identifying modifiable provider perspectives that are associated with decreased racial disparities will help in the design of effective educational interventions ... Full text Link to item Cite

Feasibility of a Digital Health Intervention to Improve Diet Quality Among Women With High Blood Pressure: Randomized Controlled Feasibility Trial.

Journal Article JMIR Mhealth Uhealth · December 7, 2020 BACKGROUND: Over 100 million individuals have high blood pressure, and more than half of them are women. The Dietary Approaches to Stop Hypertension (DASH) dietary pattern is a proven lifestyle approach to lower blood pressure, yet population-level adheren ... Full text Link to item Cite

Association between patient race and staff resuscitation efforts after cardiac arrest in outpatient dialysis clinics: A study from the CARES surveillance group.

Journal Article Resuscitation · November 2020 BACKGROUND: Cardiac arrest is the leading cause of death among patients receiving hemodialysis. Despite guidelines recommending CPR training and AED presence in dialysis clinics, rates of CPR and AED use by dialysis staff are suboptimal. Given that racial ... Full text Open Access Link to item Cite

Preliminary evidence of effects of potassium chloride on a metabolomic path to diabetes and cardiovascular disease.

Journal Article Metabolomics · June 18, 2020 INTRODUCTION: Low potassium intake can affect cardiovascular disease (CVD) risk and cardiometabolic risk factors. OBJECTIVE: We hypothesize that potassium chloride (KCl) supplementation can improve cardiovascular risk metabolomic profile. METHODS: In this ... Full text Link to item Cite

Efficacy of catheter-based renal denervation in the absence of antihypertensive medications (SPYRAL HTN-OFF MED Pivotal): a multicentre, randomised, sham-controlled trial.

Journal Article Lancet · May 2, 2020 BACKGROUND: Catheter-based renal denervation has significantly reduced blood pressure in previous studies. Following a positive pilot trial, the SPYRAL HTN-OFF MED (SPYRAL Pivotal) trial was designed to assess the efficacy of renal denervation in the absen ... Full text Link to item Cite

Abstract MP43: Urine And Plasma Metabolome of Healthy Adults Consuming the Dietary Approaches to Stop Hypertension Diet: A Pilot Study

Conference Circulation · March 3, 2020 The mechanisms of the Dietary Approaches to Stop Hypertension (DASH) diet on various health markers remain unclear. The objective of this study was to identify plasma and urine metabolites altered by DASH that may elucidate mechanisms ... Full text Cite

In-Hospital Cardiac Arrest Resuscitation Practices and Outcomes in Maintenance Dialysis Patients.

Journal Article Clin J Am Soc Nephrol · February 7, 2020 BACKGROUND AND OBJECTIVES: Patients on maintenance dialysis with in-hospital cardiac arrest have been reported to have worse outcomes relative to those not on dialysis; however, it is unknown if poor outcomes are related to the quality of resuscitation. Us ... Full text Link to item Cite

Feasibility of a Digital Health Intervention to Improve Diet Quality Among Women With High Blood Pressure: Randomized Controlled Feasibility Trial (Preprint)

Journal Article · December 18, 2019 BACKGROUNDOver 100 million individuals have high blood pressure, and more than half of them are women. The Dietary Approaches to Stop Hypertension (DASH) dietary pattern is a proven lifes ... Full text Cite

DASH Diet and Blood Pressure Among Black Americans With and Without CKD: The Jackson Heart Study.

Journal Article Am J Hypertens · September 24, 2019 BACKGROUND: The Dietary Approaches to Stop Hypertension (DASH) diet lowers blood pressure (BP) more effectively in blacks compared to other US racial subgroups. Considering chronic kidney disease (CKD) raises BP through complex mechanisms, DASH may affect ... Full text Link to item Cite

Deconstructing Weight Management Interventions for Young Adults: Looking Inside the Black Box of the EARLY Consortium Trials.

Journal Article Obesity (Silver Spring) · July 2019 OBJECTIVE: The goal of the present study was to deconstruct the 17 treatment arms used in the Early Adult Reduction of weight through LifestYle (EARLY) weight management trials. METHODS: Intervention materials were coded to reflect behavioral domains and b ... Full text Link to item Cite

The Effect of a Digital Behavioral Weight Loss Intervention on Adherence to the Dietary Approaches to Stop Hypertension (DASH) Dietary Pattern in Medically Vulnerable Primary Care Patients: Results from a Randomized Controlled Trial.

Journal Article J Acad Nutr Diet · April 2019 BACKGROUND: Obesity treatment focuses primarily on reducing overall caloric intake with limited focus on improving diet quality. The Dietary Approaches to Stop Hypertension (DASH) dietary pattern is effective in managing hypertension and other chronic cond ... Full text Link to item Cite

Outcomes for Hemodialysis Patients Given Cardiopulmonary Resuscitation for Cardiac Arrest at Outpatient Dialysis Clinics.

Journal Article J Am Soc Nephrol · March 2019 BACKGROUND: Out-of-hospital cardiac arrest, the leading cause of death among patients on hemodialysis, occurs frequently within outpatient dialysis centers. Practice guidelines recommend resuscitation training for all dialysis clinic staff and on-site defi ... Full text Link to item Cite

Effectiveness of an App and Provider Counseling for Obesity Treatment in Primary Care.

Journal Article Am J Prev Med · December 2018 INTRODUCTION: Obesity treatment is less successful for socioeconomically disadvantaged populations, particularly when delivered in primary care. Digital health strategies can extend the reach of clinical obesity treatments to care settings serving patients ... Full text Link to item Cite

The Association Between Engagement and Weight Loss Through Personal Coaching and Cell Phone Interventions in Young Adults: Randomized Controlled Trial.

Journal Article JMIR Mhealth Uhealth · October 18, 2018 BACKGROUND: Understanding how engagement in mobile health (mHealth) weight loss interventions relates to weight change may help develop effective intervention strategies. OBJECTIVE: This study aims to examine the (1) patterns of participant engagement over ... Full text Open Access Link to item Cite

Design and Evaluation of an Interdisciplinary Health Disparities Research Curriculum.

Journal Article J Natl Med Assoc · August 2018 BACKGROUND: Disparities in health and healthcare are widely documented for underrepresented racial and ethnic populations across a spectrum of diseases and care settings. An evidence base for addressing racial and ethnic disparities in health and healthcar ... Full text Link to item Cite

Improvement in insulin resistance after gastric bypass surgery is correlated with a decline in plasma 2-hydroxybutyric acid.

Journal Article Surg Obes Relat Dis · August 2018 BACKGROUND: Gastric bypass surgery for weight reduction often corrects dysglycemia in diabetic patients, but a full understanding of the underlying biochemical pathways continues to be investigated. OBJECTIVES: To explore the effects of weight loss by surg ... Full text Link to item Cite

Effect of renal denervation on blood pressure in the presence of antihypertensive drugs: 6-month efficacy and safety results from the SPYRAL HTN-ON MED proof-of-concept randomised trial.

Journal Article Lancet · June 9, 2018 BACKGROUND: Previous catheter-based renal denervation studies have reported variable efficacy results. We aimed to evaluate safety and blood pressure response after renal denervation or sham control in patients with uncontrolled hypertension on antihyperte ... Full text Link to item Cite

The Association Between Engagement and Weight Loss Through Personal Coaching and Cell Phone Interventions in Young Adults: Randomized Controlled Trial (Preprint)

Journal Article · March 22, 2018 BACKGROUNDUnderstanding how engagement in mobile health (mHealth) weight loss interventions relates to weight change may help develop effective intervention strategies. ... Full text Open Access Cite

Ambulatory blood pressure in the dash diet trial: Effects of race and albuminuria.

Journal Article J Clin Hypertens (Greenwich) · February 2018 We evaluated whether low-grade albuminuria or black race modulates ambulatory blood pressure (BP) or nocturnal BP response to the DASH diet. Among 202 adults enrolled in the DASH multicenter trial who were fed the DASH or control diet for 8 weeks, reductio ... Full text Link to item Cite

Effects of potassium supplements on glucose metabolism in African Americans with prediabetes: a pilot trial.

Journal Article Am J Clin Nutr · December 2017 Background: Low potassium has been identified both as a risk factor for type 2 diabetes and as a mediator of the racial disparity in diabetes risk. Low potassium could be a potentially modifiable risk factor, particularly for African Americans.Objective: W ... Full text Link to item Cite

Catheter-based renal denervation in patients with uncontrolled hypertension in the absence of antihypertensive medications (SPYRAL HTN-OFF MED): a randomised, sham-controlled, proof-of-concept trial.

Journal Article Lancet · November 11, 2017 BACKGROUND: Previous randomised renal denervation studies did not show consistent efficacy in reducing blood pressure. The objective of our study was to evaluate the effect of renal denervation on blood pressure in the absence of antihypertensive medicatio ... Full text Link to item Cite

Serum Potassium Levels and Risk of Sudden Cardiac Death Among Patients With Chronic Kidney Disease and Significant Coronary Artery Disease.

Journal Article Kidney Int Rep · November 2017 INTRODUCTION: Chronic kidney disease (CKD) patients have increased risks of sudden cardiac arrest and sudden cardiac death (SCA/SCD) that are not explained by traditional risk factors. We examined associations between serum potassium and SCA/SCD in a large ... Full text Link to item Cite

The DASH Diet, 20 Years Later.

Journal Article JAMA · April 18, 2017 Full text Link to item Cite

National patterns in intensity and frequency of outpatient care for apparent treatment-resistant hypertension.

Journal Article Am Heart J · April 2017 BACKGROUND: Apparent treatment-resistant hypertension (aTRH) is associated with an increased risk of adverse cardiovascular outcomes. We studied the frequency and intensity of care for aTRH among participants aged 65 years and older in the US-based REGARDS ... Full text Link to item Cite

Serum potassium is a predictor of incident diabetes in African Americans with normal aldosterone: the Jackson Heart Study.

Journal Article Am J Clin Nutr · February 2017 BACKGROUND: Low-normal potassium is a risk factor for diabetes and may account for some of the racial disparity in diabetes risk. Aldosterone affects serum potassium and is associated with insulin resistance. OBJECTIVES: We sought to confirm the associatio ... Full text Open Access Link to item Cite

Apolipoprotein L1 Genetic Variants Are Associated with Chronic Kidney Disease but Not with Cardiovascular Disease in a Population Referred for Cardiac Catheterization.

Journal Article Cardiorenal Med · February 2017 BACKGROUND: While the association between APOL1 genetic variants and chronic kidney disease (CKD) has been established, their association with cardiovascular disease (CVD) is unclear. This study sought to understand CKD and cardiovascular risk conferred by ... Full text Link to item Cite

Family PArtners in Lifestyle Support (PALS): Family-based weight loss for African American adults with type 2 diabetes.

Journal Article Obesity (Silver Spring) · January 2017 OBJECTIVE: To develop and test a family-centered behavioral weight loss intervention for African American adults with type 2 diabetes. METHODS: In this randomized trial, dyads consisting of an African American adult with overweight or obesity and type 2 di ... Full text Open Access Link to item Cite

Nutrition, lifestyle, and hypertension

Chapter · January 1, 2017 Hypertension is a major risk factor for coronary heart disease, stroke, and premature death and a leading risk factor for global disease burden. Prevalence for those 18 years and older in the United States has remained around 29% since 1999 with little imp ... Full text Cite

Short-term effects of the DASH diet in adults with moderate chronic kidney disease: a pilot feeding study.

Journal Article Clin Kidney J · August 2016 BACKGROUND: Although the Dietary Approaches to Stop Hypertension (DASH) diet lowers blood pressure (BP) for adults with normal kidney function, evidence is lacking regarding its safety and efficacy in chronic kidney disease (CKD). We aimed to test the effe ... Full text Open Access Link to item Cite

Track: A randomized controlled trial of a digital health obesity treatment intervention for medically vulnerable primary care patients.

Journal Article Contemp Clin Trials · May 2016 INTRODUCTION: Obesity continues to disproportionately affect medically vulnerable populations. Digital health interventions may be effective for delivering obesity treatment in low-resource primary care settings. METHODS: Track is a 12-month randomized con ... Full text Open Access Link to item Cite

The impact of continued intervention on weight: Five-year results from the weight loss maintenance trial.

Journal Article Obesity (Silver Spring) · May 2016 OBJECTIVE: In the Weight Loss Maintenance (WLM) Trial, a personal contact (PC) intervention sustained greater weight loss relative to a self-directed (SD) group over 30 months. This study investigated the effects of continued intervention over an additiona ... Full text Link to item Cite

Potassium Measures and Their Associations with Glucose and Diabetes Risk: The Multi-Ethnic Study of Atherosclerosis (MESA).

Journal Article PLoS One · 2016 BACKGROUND: Recent studies have found low-normal potassium (K) to be associated with increased diabetes risk. We sought to verify these associations in a multi-ethnic US cohort; and to determine if these associations extend to US Hispanics and Asian-Americ ... Full text Open Access Link to item Cite

Adaptive intervention design in mobile health: Intervention design and development in the Cell Phone Intervention for You trial.

Journal Article Clin Trials · December 2015 BACKGROUND/AIMS: The obesity epidemic has spread to young adults, and obesity is a significant risk factor for cardiovascular disease. The prominence and increasing functionality of mobile phones may provide an opportunity to deliver longitudinal and scala ... Full text Open Access Link to item Cite

Cell phone intervention for you (CITY): A randomized, controlled trial of behavioral weight loss intervention for young adults using mobile technology.

Journal Article Obesity (Silver Spring) · November 2015 OBJECTIVE: To determine the effect on weight of two mobile technology-based (mHealth) behavioral weight loss interventions in young adults. METHODS: Randomized, controlled comparative effectiveness trial in 18- to 35-year-olds with BMI ≥ 25 kg/m(2) (overwe ... Full text Open Access Link to item Cite

NATIONAL PATTERNS IN INTENSITY OF OUTPATIENT CARE FOR APPARENT TREATMENT RESISTANT HYPERTENSION

Conference Journal of the American College of Cardiology · March 2015 Full text Cite

Potassium and glucose measures in older adults: the Cardiovascular Health Study.

Journal Article J Gerontol A Biol Sci Med Sci · February 2015 BACKGROUND: We sought to determine the impacts of serum and dietary potassium measures on glucose metabolism and diabetes risk in older adults. METHODS: Among participants of the Cardiovascular Health Study, a community-based cohort of older American adult ... Full text Link to item Cite

Predictors of blood pressure response in the SYMPLICITY HTN-3 trial.

Journal Article Eur Heart J · January 21, 2015 AIMS: The SYMPLICITY HTN-3 randomized, blinded, sham-controlled trial confirmed the safety of renal denervation (RDN), but did not meet its primary efficacy endpoint. Prior RDN studies have demonstrated significant and durable reductions in blood pressure. ... Full text Link to item Cite

Psychosocial predictors of weight regain in the weight loss maintenance trial.

Journal Article J Behav Med · December 2014 This study's purpose was to identify psychosocial predictors of weight loss maintenance in a multi-site clinical trial, following a group-based weight loss program. Participants (N = 1025) were predominately women (63%) and 38% were Black (mean age = 55.6 ... Full text Link to item Cite

Apparent treatment-resistant hypertension and chronic kidney disease: another cardiovascular-renal syndrome?

Journal Article Adv Chronic Kidney Dis · November 2014 To identify patients at increased risk of cardiovascular (CV) outcomes, apparent treatment-resistant hypertension (aTRH) is defined as having a blood pressure above goal despite the use of 3 or more antihypertensive therapies of different classes at maxima ... Full text Open Access Link to item Cite

Predictors of dietary change among those who successfully lost weight in phase I of the Weight Loss Maintenance Trial.

Journal Article Nutr Diet · September 2014 AIM: Dietary changes occurring during weight loss interventions can vary. The present study tested if pretreatment psychosocial, dietary and demographic factors were associated with changes in fat intake and fruit and vegetable intake during a weight loss ... Full text Link to item Cite

The EARLY trials: a consortium of studies targeting weight control in young adults.

Journal Article Transl Behav Med · September 2014 Young adulthood has been identified as a high-risk period for the development of obesity but few interventions have been tested in this population. One way to escalate our learning about effective interventions is to test a number of interventions simultan ... Full text Link to item Cite

Examining behavioral processes through which lifestyle interventions promote weight loss: results from PREMIER.

Journal Article Obesity (Silver Spring) · April 2014 OBJECTIVE: To examine the behavioral processes through which lifestyle interventions impacted weight loss. METHODS: The analyses were limited to overweight and obese Black and White adults randomized to a PREMIER lifestyle intervention (N = 501). Structura ... Full text Link to item Cite

Weight loss intervention for young adults using mobile technology: design and rationale of a randomized controlled trial - Cell Phone Intervention for You (CITY).

Journal Article Contemp Clin Trials · March 2014 BACKGROUND: The obesity epidemic has spread to young adults, leading to significant public health implications later in adulthood. Intervention in early adulthood may be an effective public health strategy for reducing the long-term health impact of the ep ... Full text Open Access Link to item Cite

2014 evidence-based guideline for the management of high blood pressure in adults: report from the panel members appointed to the Eighth Joint National Committee (JNC 8).

Journal Article JAMA · February 5, 2014 Hypertension is the most common condition seen in primary care and leads to myocardial infarction, stroke, renal failure, and death if not detected early and treated appropriately. Patients want to be assured that blood pressure (BP) treatment will reduce ... Full text Link to item Cite

Branch chain amino acids: biomarkers of health and disease.

Journal Article Curr Opin Clin Nutr Metab Care · January 2014 PURPOSE OF REVIEW: There is burgeoning evidence that branch chain amino acids (BCAAs) are biomarkers of metabolic, cardiovascular, renal and cerebrovascular disease. The purpose of this review is to summarize the current evidence in this area. RECENT FINDI ... Full text Link to item Cite

Greater weight loss with increasing age in the weight loss maintenance trial

Journal Article Obesity · January 1, 2014 Objective To determine the effect of age on weight loss and weight loss maintenance in participants in the Weight Loss Maintenance trial (WLM). Design and Methods Secondary analysis of a randomized controlled trial of overweight/obese adults with CVD risk ... Full text Cite

Impact of delivery models on understanding genomic risk for type 2 diabetes.

Journal Article Public Health Genomics · 2014 BACKGROUND: Genetic information, typically communicated in-person by genetic counselors, can be challenging to comprehend; delivery of this information online--as is becoming more common--has the potential of increasing these challenges. METHODS: To addres ... Full text Link to item Cite

Examining behavioral processes through which lifestyle interventions promote weight loss: Results from PREMIER

Journal Article Obesity · January 1, 2014 Objective To examine the behavioral processes through which lifestyle interventions impacted weight loss. Methods The analyses were limited to overweight and obese Black and White adults randomized to a PREMIER lifestyle intervention (N=501). Structural eq ... Full text Cite

Impact of Kidney Function on Effects of the Dietary Approaches to Stop Hypertension (Dash) Diet.

Journal Article J Hypertens (Los Angel) · 2014 OBJECTIVES: Although the Dietary Approaches to Stop Hypertension (DASH) diet lowers blood pressure in adults with hypertension, how kidney function impacts this effect is not known. We evaluated whether Estimated Glomerular Filtration Rate (eGFR) modifies ... Full text Open Access Link to item Cite

Greater weight loss with increasing age in the weight loss maintenance trial.

Journal Article Obesity (Silver Spring) · January 2014 OBJECTIVE: To determine the effect of age on weight loss and weight loss maintenance in participants in the Weight Loss Maintenance trial (WLM). DESIGN AND METHODS: Secondary analysis of a randomized controlled trial of overweight/obese adults with CVD ris ... Full text Link to item Cite

Weight loss history as a predictor of weight loss: results from Phase I of the weight loss maintenance trial.

Journal Article J Behav Med · December 2013 Past studies have suggested that weight loss history is associated with subsequent weight loss. However, questions remain whether method and amount of weight lost in previous attempts impacts current weight loss efforts. This study utilized data from the W ... Full text Link to item Cite

Race and sex differences in small-molecule metabolites and metabolic hormones in overweight and obese adults.

Journal Article OMICS · December 2013 In overweight/obese individuals, cardiometabolic risk factors differ by race and sex categories. Small-molecule metabolites and metabolic hormone levels might also differ across these categories and contribute to risk factor heterogeneity. To explore this ... Full text Link to item Cite

Association of a reduction in central obesity and phosphorus intake with changes in urinary albumin excretion: the PREMIER study.

Journal Article Am J Kidney Dis · November 2013 BACKGROUND: Excess adiposity and dietary factors may be important determinants of urinary albumin excretion (UAE). STUDY DESIGN: Observational analysis of PREMIER, a randomized trial designed to lower blood pressure using behavioral interventions (counseli ... Full text Open Access Link to item Cite

The influence of a physician and patient intervention program on dietary intake.

Journal Article J Acad Nutr Diet · November 2013 BACKGROUND: Efficient dietary interventions for patients with hypertension in clinical settings are needed. OBJECTIVE: To assess the separate and combined influence of a physician intervention (MD-I) and a patient intervention (PT-I) on dietary intakes of ... Full text Link to item Cite

Nutrition, Lifestyle, and Hypertension

Journal Article · August 29, 2013 Full text Cite

Branched chain amino acids are novel biomarkers for discrimination of metabolic wellness.

Journal Article Metabolism · July 2013 OBJECTIVE: To identify novel biomarkers through metabolomic profiles that distinguish metabolically well (MW) from metabolically unwell (MUW) individuals, independent of body mass index (BMI). MATERIALS/METHODS: This study was conducted as part of the Meas ... Full text Link to item Cite

Recruiting young adults into a weight loss trial: report of protocol development and recruitment results.

Journal Article Contemp Clin Trials · July 2013 Obesity has spread to all segments of the U.S. population. Young adults, aged 18-35 years, are rarely represented in clinical weight loss trials. We conducted a qualitative study to identify factors that may facilitate recruitment of young adults into a we ... Full text Open Access Link to item Cite

Impact of 5-year weight change on blood pressure: results from the Weight Loss Maintenance trial.

Journal Article J Clin Hypertens (Greenwich) · July 2013 In this secondary analysis of the Weight Loss Maintenance trial, the authors assessed the relationship between blood pressure (BP) change and weight change in overweight and obese adults with hypertension and/or dyslipidemia who were randomized to 1 of 3 w ... Full text Open Access Link to item Cite

Effects of changes in potassium with valsartan use on diabetes risk: Nateglinide and Valsartan in Impaired Glucose Tolerance Outcomes Research (NAVIGATOR) trial.

Journal Article Am J Hypertens · June 2013 BACKGROUND: Low and low-normal serum potassium is associated with an increased risk of diabetes. We hypothesized that the protective effect of valsartan on diabetes risk could be mediated by its effect of raising serum potassium. METHODS: We analyzed data ... Full text Link to item Cite

Public knowledge of and attitudes toward genetics and genetic testing.

Journal Article Genet Test Mol Biomarkers · April 2013 BACKGROUND: Variable health literacy and genetic knowledge may pose significant challenges to engaging the general public in personal genomics, specifically with respect to promoting risk comprehension and healthy behaviors. METHODS: We are conducting a mu ... Full text Link to item Cite

Impact of participant and interventionist race concordance on weight loss outcomes.

Journal Article Obesity (Silver Spring) · April 2013 OBJECTIVE: We have previously shown that racial composition of behavioral intervention groups does not affect achieved weight loss. However, it is unclear if the race of the interventionist affects intervention outcomes. The objective of this analysis is t ... Full text Link to item Cite

Family diabetes matters: a view from the other side.

Journal Article J Gen Intern Med · March 2013 BACKGROUND: Typically, chronic disease self-management happens in a family context, and for African American adults living with diabetes, family seems to matter in self-management processes. Many qualitative studies describe family diabetes interactions fr ... Full text Link to item Cite

Self-efficacy as a predictor of weight change and behavior change in the PREMIER trial.

Journal Article J Nutr Educ Behav · 2013 OBJECTIVES: Determine whether self-efficacy independently predicted weight loss in a behavioral intervention and explore factors that influence the path between self-efficacy and weight change. DESIGN: Secondary analysis of the PREMIER trial, a randomized ... Full text Link to item Cite

Dietary intakes consistent with the DASH dietary pattern reduce blood pressure increase with age and risk for stroke in a Chinese population.

Journal Article Asia Pac J Clin Nutr · 2013 The Dietary Approaches to Stop Hypertension (DASH) diet has been proven to effectively lower blood pressure (BP), and associate with a lower cardiovascular disease and stroke risk in mainly non-Asians. Further, it is unclear if adhering to the DASH target ... Link to item Cite

Dietary intakes consistent with the DASH dietary pattern reduce blood pressure increase with age and risk for stroke in a Chinese population.

Journal Article Asia Pac J Clin Nutr · 2013 The Dietary Approaches to Stop Hypertension (DASH) diet has been proven to effectively lower blood pressure(BP), and associate with a lower cardiovascular disease and stroke risk in mainly non-Asians. Further, it is unclear if adhering to the DASH target n ... Link to item Cite

Sex hormone changes during weight loss and maintenance in overweight and obese postmenopausal African-American and non-African-American women.

Journal Article Breast Cancer Res · October 31, 2012 INTRODUCTION: Changes in sex hormones with weight loss might have implications for breast cancer prevention but have not been examined extensively, particularly in African-American (AA) women. METHODS: We conducted a prospective study of 278 overweight/obe ... Full text Link to item Cite

The Dietary Approaches to Stop Hypertension (DASH) eating pattern in special populations.

Journal Article Curr Hypertens Rep · October 2012 The Dietary Approaches to Stop Hypertension (DASH) trial showed that a diet rich in fruits, vegetables, low-fat dairy products with reduced total and saturated fat, cholesterol, and sugar-sweetened products effectively lowers blood pressure in individuals ... Full text Open Access Link to item Cite

Predictors of long-term weight loss in adults with modest initial weight loss, by sex and race.

Journal Article Obesity (Silver Spring) · September 2012 Effective weight management interventions could reduce race-sex disparities in cardiovascular disease (CVD), yet little is known about factors associated with successful weight loss maintenance in race-sex subgroups. In the Weight Loss Maintenance trial (W ... Full text Link to item Cite

Implementation of automated reporting of estimated glomerular filtration rate among Veterans Affairs laboratories: a retrospective study.

Journal Article BMC Med Inform Decis Mak · July 12, 2012 BACKGROUND: Automated reporting of estimated glomerular filtration rate (eGFR) is a recent advance in laboratory information technology (IT) that generates a measure of kidney function with chemistry laboratory results to aid early detection of chronic kid ... Full text Open Access Link to item Cite

Impact of Participant and Interventionist Race Concordance on Weight Loss Outcomes.

Journal Article Obesity (Silver Spring) · July 2, 2012 We have previously shown that racial composition of behavioral intervention groups does not affect achieved weight loss. However, it is unclear if the race of the interventionist affects intervention outcomes. The objective of this analysis is to estimate ... Full text Link to item Cite

Branched-chain amino acid levels are associated with improvement in insulin resistance with weight loss.

Journal Article Diabetologia · February 2012 AIMS/HYPOTHESIS: Insulin resistance (IR) improves with weight loss, but this response is heterogeneous. We hypothesised that metabolomic profiling would identify biomarkers predicting changes in IR with weight loss. METHODS: Targeted mass spectrometry-base ... Full text Link to item Cite

Overview

Chapter · 2012 Cite

Nutrition, lifestyle factors, and blood pressure

Book · January 1, 2012 Even though enormous advancements have been made in identifying evidence-based lifestyle strategies for hypertension prevention and management, little progress has been made in implementing these proven strategies. Nutrition, Lifestyle Factors, and Blood P ... Cite

Preface

Book · January 1, 2012 Cite

Practical application

Chapter · January 1, 2012 In this book, we have attempted to be comprehensive in presenting evidence on the effect of nutrition and other lifestyle factors on blood pressure (BP). A broad discussion of this evidence is essential for understanding the current state of science. We ha ... Cite

Overview

Book · January 1, 2012 In order for ef cacious nutritional or lifestyle interventions to improve BP control, these behaviors must be adopted in the real world. In this book, we deliberately refer to “lifestyle change” rather than “going on a diet” or “starting an ex ercise progr ... Cite

Blood Pressure-Lowering Mechanisms of the DASH Dietary Pattern.

Journal Article J Nutr Metab · 2012 Potential blood pressure- (BP-) lowering mechanisms of the DASH dietary pattern were measured in 20 unmedicated hypertensive adults in a controlled feeding study. At screening, participants averaged 44.3 ± 7.8 years, BMI 33.9 ± 6.6 Kg/m(2), and BP 144.2 ± ... Full text Open Access Link to item Cite

The Latino Health Project: pilot testing a culturally adapted behavioral weight loss intervention in obese and overweight Latino adults.

Journal Article Ethn Dis · 2012 OBJECTIVE: To pilot test a culturally adapted behavioral weight loss intervention in obese and overweight Latino adults. DESIGN: Pilot study. SETTING: Latino community organization in Durham, North Carolina. PARTICIPANTS: Overweight and obese, self-identif ... Open Access Link to item Cite

Establishing faculty needs and priorities for peer-mentoring groups using a nominal group technique.

Journal Article Med Teach · 2012 Peer-mentoring groups are purported to enhance faculty productivity and retention, but the literature about implementation is sparse. Nominal Group Sessions (n=5) with 66 faculty members in different tracks developed prioritized lists of unmet professional ... Full text Link to item Cite

The MURDOCK Study: a long-term initiative for disease reclassification through advanced biomarker discovery and integration with electronic health records.

Journal Article Am J Transl Res · 2012 BACKGROUND: Facing critically low return per dollar invested on clinical research and clinical care, the American biomedical enterprise is in need of a significant transformation. A confluence of high-throughput "omic" technologies and increasing adoption ... Link to item Cite

Branching out for detection of type 2 diabetes.

Journal Article Cell Metab · May 4, 2011 Type 2 diabetes is an epidemic disease worldwide, but it is difficult to predict its appearance in the general population. A recent study demonstrates that circulating concentrations of a small group of essential amino acids predict risk for diabetes, cont ... Full text Link to item Cite

Differential metabolic impact of gastric bypass surgery versus dietary intervention in obese diabetic subjects despite identical weight loss.

Journal Article Sci Transl Med · April 27, 2011 Glycemic control is improved more after gastric bypass surgery (GBP) than after equivalent diet-induced weight loss in patients with morbid obesity and type 2 diabetes mellitus. We applied metabolomic profiling to understand the mechanisms of this better m ... Full text Link to item Cite

Modulation of the BP response to diet by genes in the renin-angiotensin system and the adrenergic nervous system.

Journal Article Am J Hypertens · February 2011 BACKGROUND: Essential hypertension results from the interaction of several genetic and environmental factors. Identification of genetic factors that modulate blood pressure (BP) response to interventions can lead to improved strategies for prevention and c ... Full text Link to item Cite

Physician characteristics as predictors of blood pressure control in patients enrolled in the hypertension improvement project (HIP).

Journal Article J Clin Hypertens (Greenwich) · February 2011 The authors sought to examine the relationship between physician characteristics and patient blood pressure (BP) in participants enrolled in the Hypertension Improvement Project (HIP). In this cross-sectional study using baseline data of HIP participants, ... Full text Link to item Cite

Family functioning and weight loss in a sample of african americans and whites.

Journal Article Ann Behav Med · December 2010 BACKGROUND: Traditionally, weight management behavioral research has focused on individual-level influences, with little attention given to interpersonal factors that relate to the family behavioral context. PURPOSE: This research examines the association ... Full text Link to item Cite

Accuracy of self-reported height and weight in a community-based sample of older African Americans and whites.

Journal Article J Gerontol A Biol Sci Med Sci · October 2010 BACKGROUND: To ascertain accuracy of self-reported height, weight (and hence body mass index) in African American and white women and men older than 70 years of age. METHOD: The sample consisted of cognitively intact participants at the third in-person wav ... Full text Link to item Cite

Beta2-adrenergic receptor genotype affects the renin-angiotensin-aldosterone system response to the Dietary Approaches to Stop Hypertension (DASH) dietary pattern.

Journal Article Am J Clin Nutr · August 2010 BACKGROUND: Beta(2)-adrenergic receptor (beta2-AR) is a susceptibility locus for hypertension, and polymorphisms at this site relate to salt sensitivity and low plasma renin activity (PRA). The Dietary Approaches to Stop Hypertension (DASH) dietary pattern ... Full text Link to item Cite

Microalbuminuria predicts overt proteinuria among patients with HIV infection.

Journal Article HIV Med · August 2010 BACKGROUND: This study examines the association between microalbuminuria and the development of proteinuria among HIV-infected persons. METHODS: A total of 948 subjects provided urine samples for albumin, protein and creatinine measurements semiannually. M ... Full text Link to item Cite

Associations of internet website use with weight change in a long-term weight loss maintenance program.

Journal Article J Med Internet Res · July 27, 2010 BACKGROUND: The Weight Loss Maintenance Trial (WLM) compared two long-term weight-maintenance interventions, a personal contact arm and an Internet arm, with a no-treatment control after an initial six-month Phase I weight loss program. The Internet arm fo ... Full text Link to item Cite

Hypertension Improvement Project (HIP) Latino: results of a pilot study of lifestyle intervention for lowering blood pressure in Latino adults.

Journal Article Ethn Health · June 2010 OBJECTIVES: To assess the feasibility of a culturally tailored behavioral intervention for improving hypertension-related health behaviors in Hispanic/Latino adults. DESIGN: Feasibility pilot study in a community health center and a Latino organization in ... Full text Link to item Cite

Economic evaluation of home blood pressure monitoring with or without telephonic behavioral self-management in patients with hypertension.

Journal Article Am J Hypertens · February 2010 BACKGROUND: The Take Control of Your Blood Pressure trial evaluated the effect of a multicomponent telephonic behavioral lifestyle intervention, patient self-monitoring, and both interventions combined compared with usual care on reducing systolic blood pr ... Full text Link to item Cite

Hypertension improvement project: randomized trial of quality improvement for physicians and lifestyle modification for patients.

Journal Article Hypertension · December 2009 Despite widely publicized hypertension treatment guidelines for physicians and lifestyle recommendations for patients, blood pressure control rates remain low. In community-based primary care clinics, we performed a nested, 2 x 2 randomized, controlled tri ... Full text Link to item Cite

Two self-management interventions to improve hypertension control: a randomized trial.

Journal Article Ann Intern Med · November 17, 2009 BACKGROUND: Fewer than 40% of persons with hypertension in the United States have adequate blood pressure (BP) control. OBJECTIVE: To compare 2 self-management interventions for improving BP control among hypertensive patients. DESIGN: A 2 x 2 randomized t ... Full text Link to item Cite

Development and implementation cost analysis of telephone- and Internet-based interventions for the maintenance of weight loss.

Journal Article Int J Technol Assess Health Care · July 2009 OBJECTIVES: The Weight Loss Maintenance Trial (WLM) was a multicenter, randomized trial comparing two weight loss maintenance interventions, a personal contact (PC) program with primarily telephone-based monthly contacts, and an Internet-based program (int ... Full text Link to item Cite

Reduction in consumption of sugar-sweetened beverages is associated with weight loss: the PREMIER trial.

Journal Article Am J Clin Nutr · May 2009 BACKGROUND: Consumption of liquid calories from beverages has increased in parallel with the obesity epidemic in the US population, but their causal relation remains unclear. OBJECTIVE: The objective of this study was to examine how changes in beverage con ... Full text Link to item Cite

The effects of dietary patterns on urinary albumin excretion: results of the Dietary Approaches to Stop Hypertension (DASH) Trial.

Journal Article Am J Kidney Dis · April 2009 BACKGROUND: Dietary studies designed to decrease the urinary albumin excretion rate (AER) typically reduce protein by increasing lower protein plant foods and decreasing higher protein animal products. STUDY DESIGN: We evaluated AER while increasing protei ... Full text Link to item Cite

A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance.

Journal Article Cell Metab · April 2009 Metabolomic profiling of obese versus lean humans reveals a branched-chain amino acid (BCAA)-related metabolite signature that is suggestive of increased catabolism of BCAA and correlated with insulin resistance. To test its impact on metabolic homeostasis ... Full text Link to item Cite

Effects of exercise on lipoprotein particles in women with polycystic ovary syndrome.

Journal Article Med Sci Sports Exerc · March 2009 PURPOSE: Women with polycystic ovary syndrome (PCOS) commonly have insulin resistance. Insulin resistance is associated with marked abnormalities of lipoprotein size and subclass particle concentration. The purpose of this study was to examine the effects ... Full text Link to item Cite

Hypertension Improvement Project (HIP): study protocol and implementation challenges.

Journal Article Trials · February 26, 2009 BACKGROUND: Hypertension affects 29% of the adult U.S. population and is a leading cause of heart disease, stroke, and kidney failure. Despite numerous effective treatments, only 53% of people with hypertension are at goal blood pressure. The chronic care ... Full text Open Access Link to item Cite

The STEDMAN project: biophysical, biochemical and metabolic effects of a behavioral weight loss intervention during weight loss, maintenance, and regain.

Journal Article OMICS · February 2009 The Study of the Effects of Diet on Metabolism and Nutrition (STEDMAN) Project uses comprehensive metabolic profiling to probe biochemical mechanisms of weight loss in humans. Measurements at baseline, 2 and 4 weeks, 6 and 12 months included diet, body com ... Full text Link to item Cite

Patient characteristics associated with receipt of lifestyle behavior advice.

Journal Article N C Med J · 2009 BACKGROUND: Lifestyle behaviors such as reducing weight if overweight or obese, reducing salt intake, exercising, reducing alcohol intake, quitting smoking, and eating a healthy diet are related to the prevention and control of chronic diseases. However th ... Link to item Cite

Ghrelin concentrations in Prader-Willi syndrome (PWS) infants and children: changes during development.

Journal Article Clin Endocrinol (Oxf) · December 2008 BACKGROUND: Prader-Willi syndrome (PWS) is associated with failure to thrive in infancy and progressive hyperphagia and obesity in childhood. This progressive weight gain is associated with hyperghrelinaemia and increased insulin sensitivity. The role of g ... Full text Link to item Cite

Weight loss during the intensive intervention phase of the weight-loss maintenance trial.

Journal Article Am J Prev Med · August 2008 BACKGROUND: To improve methods for long-term weight management, the Weight Loss Maintenance (WLM) trial, a four-center randomized trial, was conducted to compare alternative strategies for maintaining weight loss over a 30-month period. This paper describe ... Full text Link to item Cite

Effect of socioeconomic status on food availability and cost of the Dietary Approaches to Stop Hypertension (DASH) dietary pattern.

Journal Article J Clin Hypertens (Greenwich) · August 2008 The authors assessed food availability and cost of the Dietary Approaches to Stop Hypertension (DASH) dietary pattern and patients' opinion concerning diet and blood pressure by surveying grocery stores and clinic patients in low- and high-socioeconomic st ... Full text Link to item Cite

Dietary management in the prevention and treatment of hypertension: does it work?

Journal Article J Clin Hypertens (Greenwich) · August 2008 During a meeting of the American Society of Hypertension in New Orleans, LA, in May 2008, an expert panel was convened to discuss nonpharmacologic therapy in hypertension. This is an update of a panel discussion that was held in March 2007. The panel was c ... Full text Link to item Cite

Comprehensive lifestyle modification and blood pressure control

Journal Article Cardiology Review · April 1, 2008 Lifestyle recommendations for the prevention and treatment of hypertension include weight loss, reduced sodium intake, increased physical activity, limited alcohol intake, and the Dietary Approaches to Stop Hypertension (DASH) diet. The 18-month results of ... Cite

Comparison of strategies for sustaining weight loss: the weight loss maintenance randomized controlled trial.

Journal Article JAMA · March 12, 2008 CONTEXT: Behavioral weight loss interventions achieve short-term success, but re-gain is common. OBJECTIVE: To compare 2 weight loss maintenance interventions with a self-directed control group. DESIGN, SETTING, AND PARTICIPANTS: Two-phase trial in which 1 ... Full text Link to item Cite

Take Control of Your Blood Pressure (TCYB) study: a multifactorial tailored behavioral and educational intervention for achieving blood pressure control.

Journal Article Patient Educ Couns · March 2008 OBJECTIVE: Evaluating a randomized controlled trial involving a tailored behavioral intervention conducted to improve blood pressure control. METHODS: Adults with hypertension from two outpatient primary care clinics were randomly allocated to receive a nu ... Full text Link to item Cite

Predictors of weight loss maintenance in the weight loss maintenance trial

Journal Article ANNALS OF BEHAVIORAL MEDICINE · March 1, 2008 Link to item Cite

Effect of group racial composition on weight loss in African Americans.

Journal Article Obesity (Silver Spring) · February 2008 OBJECTIVE: We do not know how racial composition of a group influences behavior change for African Americans (AAs) in group-based weight loss programs. We tested the hypothesis that AA who participate in all AA weight loss intervention groups will lose mor ... Full text Link to item Cite

Design considerations and rationale of a multi-center trial to sustain weight loss: the Weight Loss Maintenance Trial.

Journal Article Clin Trials · 2008 BACKGROUND: The Weight Loss Maintenance Trial (WLM) is a multi-center, randomized, controlled trial that compares the effects of two 30-month maintenance interventions, i.e., Personal Contact (PC) and Interactive Technology (IT) to a self-directed usual ca ... Full text Link to item Cite

Altered distribution of adiponectin isoforms in children with Prader-Willi syndrome (PWS): association with insulin sensitivity and circulating satiety peptide hormones.

Journal Article Clin Endocrinol (Oxf) · December 2007 OBJECTIVE: Prader-Willi syndrome (PWS) is a genetic syndrome characterized by relative hypoinsulinaemia and normal or increased insulin sensitivity despite profound obesity. We hypothesized that this increased insulin sensitivity is mediated by increased l ... Full text Link to item Cite

Effects of PREMIER lifestyle modifications on participants with and without the metabolic syndrome.

Journal Article Hypertension · October 2007 Lifestyle modification can reduce blood pressure and lower cardiovascular risk. Established recommendations include weight loss, sodium reduction, and increased physical activity. PREMIER studied the effects of lifestyle interventions based on established ... Full text Link to item Cite

Effects of individual components of multiple behavior changes: the PREMIER trial.

Journal Article Am J Health Behav · 2007 OBJECTIVES: To assess contributions of individual lifestyle changes on systolic blood pressure (SBP) changes. METHODS: We examined associations between lifestyle behavior changes and SBP after 6 and 18 months in 782 PREMIER trial participants. RESULTS: In ... Full text Link to item Cite

The Take Control of Your Blood pressure (TCYB) study: study design and methodology.

Journal Article Contemp Clin Trials · January 2007 BACKGROUND: Among the 65 million Americans with hypertension, only approximately 31% have their blood pressure under control (<140/90 mm/Hg). Despite the damaging impact of hypertension and the availability of evidence-based target values for blood pressur ... Full text Link to item Cite

Effects of comprehensive lifestyle modification on diet, weight, physical fitness, and blood pressure control: 18-month results of a randomized trial.

Journal Article Ann Intern Med · April 4, 2006 BACKGROUND: The main 6-month results from the PREMIER trial showed that comprehensive behavioral intervention programs improve lifestyle behaviors and lower blood pressure. OBJECTIVE: To compare the 18-month effects of 2 multicomponent behavioral intervent ... Full text Link to item Cite

The Study of the Effects of Diet on Metabolism and Nutrition (STEDMAN) weight loss project: Rationale and design.

Journal Article Contemp Clin Trials · December 2005 This paper outlines the rationale and design of the Study of the Effects of Diet on Metabolism and Nutrition (STEDMAN) weight loss project, in which detailed biologic profiling of three hundred and fifty obese individuals (body mass index (BMI): 30-50 kg/m ... Full text Link to item Cite

A dietary pattern that lowers oxidative stress increases antibodies to oxidized LDL: results from a randomized controlled feeding study.

Journal Article Atherosclerosis · November 2005 BACKGROUND: Oxidation of LDL (oxLDL) is thought to have an important role in early stages of atherogenesis. Antibody to oxLDL (Ab-oxLDL) has been proposed as a biomarker which might be directly associated with oxidative stress. Yet studies designed to test ... Full text Link to item Cite

Informing cancer prevention strategies for African Americans: the relationship of African American acculturation to fruit, vegetable, and fat intake.

Journal Article J Behav Med · June 2005 Acculturation has been associated with health-related behaviors in African Americans. We sought to determine if there is a relationship between acculturation and dietary intake in African Americans. African Americans in the PREMIER trial completed the Afri ... Full text Link to item Cite

Management of prehypertension.

Journal Article Hypertension · June 2005 Full text Link to item Cite

Novel human alpha1a-adrenoceptor single nucleotide polymorphisms alter receptor pharmacology and biological function.

Journal Article Naunyn Schmiedebergs Arch Pharmacol · March 2005 We identified nine naturally-occurring human single nucleotide polymorphisms (SNPs) in the alpha(1a)-adrenoceptor (alpha(1a)AR) coding region, seven of which result in amino acid change. Utilizing rat-1 fibroblasts stably expressing wild type alpha(1a)AR o ... Full text Link to item Cite

Comparing office-based and ambulatory blood pressure monitoring in clinical trials.

Journal Article J Hum Hypertens · January 2005 Ambulatory blood pressure monitoring (ABPM) is commonly used in clinical trials. Yet, its ability to detect blood pressure (BP) change in comparison to multiple office-based measurements has received limited attention. We recorded ambulatory and five daily ... Full text Link to item Cite

Perceptions of African-American culture and implications for clinical trial design.

Journal Article Ethn Dis · 2005 OBJECTIVE: To identify unique cultural variables for African Americans that might limit the effectiveness of behavioral interventions in clinical trials. DESIGN: Focus group discussions lasting 90 minutes. SETTING: Outpatient, clinical research center. PAT ... Link to item Cite

Effect of lifestyle modifications on blood pressure by race, sex, hypertension status, and age.

Journal Article J Hum Hypertens · January 2005 Recommendations for control of high blood pressure (BP) emphasize lifestyle modification, including weight loss, reduced sodium intake, increased physical activity, and limited alcohol consumption. The Dietary Approaches to Stop Hypertension (DASH) dietary ... Full text Link to item Cite

One-year follow-up study of blood pressure and dietary patterns in dietary approaches to stop hypertension (DASH)-sodium participants.

Journal Article Am J Hypertens · December 2004 BACKGROUND: We conducted a 12-month follow-up study on participants in the Dietary Approaches to Stop Hypertension (DASH)-Sodium trial to determine the impact of the DASH diet and 150, 100, or 50 mmol/day of sodium after discontinuation of the feeding inte ... Full text Link to item Cite

The clinical epidemiology and course of the spectrum of renal diseases associated with HIV infection.

Journal Article Kidney Int · September 2004 BACKGROUND: While an understanding of the epidemiology and clinical course of HIV-associated nephropathy (HIVAN) is growing, little is known about the risk factors and clinical course of the other renal diseases that may also occur as a complication of HIV ... Full text Link to item Cite

A further subgroup analysis of the effects of the DASH diet and three dietary sodium levels on blood pressure: results of the DASH-Sodium Trial.

Journal Article Am J Cardiol · July 15, 2004 This study presents an extensive analysis of the effects on blood pressure (BP) of changes in sodium intake over a wide array of subgroups, including joint subgroups defined by age and hypertension status, race or ethnicity and hypertension status, and gen ... Full text Link to item Cite

Comprehensive lifestyle modification and blood pressure control: a review of the PREMIER trial.

Journal Article J Clin Hypertens (Greenwich) · July 2004 The PREMIER trial assessed the aggregate effect on blood pressure (BP) of nationally recommended lifestyle modifications in free-living adults with high-normal (stage 1) hypertension. Participants (N=810) were randomized to the advice-only group; the estab ... Full text Link to item Cite

Effect of the dietary approaches to stop hypertension diet and reduced sodium intake on blood pressure control.

Journal Article J Clin Hypertens (Greenwich) · July 2004 The authors hypothesized that the Dietary Approaches to Stop Hypertension (DASH) diet and reduced sodium intake would control stage 1 hypertension and reduce high-normal blood pressure (BP) to optimal levels. Adults with systolic BP 120-159 mm Hg and diast ... Full text Link to item Cite

Effect of dietary sodium intake on blood lipids: results from the DASH-sodium trial.

Journal Article Hypertension · February 2004 We evaluated the effect on serum lipids of sodium intake in 2 diets. Participants were randomly assigned to a typical American control diet or the Dietary Approaches to Stop Hypertension (DASH) diet, each prepared with 3 levels of sodium (targeted at 50, 1 ... Full text Link to item Cite

The effect of the PREMIER interventions on insulin sensitivity.

Journal Article Diabetes Care · February 2004 OBJECTIVE: This ancillary study of PREMIER sought to determine the effects on insulin sensitivity of a comprehensive behavioral intervention for hypertension with and without the Dietary Approaches to Stop Hypertension (DASH) dietary pattern. RESEARCH DESI ... Full text Link to item Cite

The DASH diet and blood pressure.

Journal Article Curr Atheroscler Rep · November 2003 High blood pressure (also called hypertension) is one of the most important and common risk factors for atherosclerotic cardiovascular disease (CVD) and other chronic diseases. National guidelines recommend that all individuals with blood pressure readings ... Full text Link to item Cite

The potential impact of nonpharmacologic population-wide blood pressure reduction on coronary heart disease events: pronounced benefits in African-Americans and hypertensives.

Journal Article Prev Med · October 2003 BACKGROUND: Previous estimates of the population-wide impact of nonpharmacologic interventions that lower blood pressure (BP) have typically assumed a uniform response to the intervention. However, several nonpharmacologic interventions reduce BP to a grea ... Full text Link to item Cite

The DASH diet and sodium reduction improve markers of bone turnover and calcium metabolism in adults.

Journal Article J Nutr · October 2003 Dietary strategies to prevent and treat osteoporosis focus on increased intake of calcium and vitamin D. Modification of whole dietary patterns and sodium reduction may also be effective. We examined the effects of two dietary patterns and three sodium lev ... Full text Link to item Cite

Individual blood pressure responses to changes in salt intake: results from the DASH-Sodium trial.

Journal Article Hypertension · October 2003 Although group characteristics are known to influence average blood pressure response to changes in salt intake, predictability of individual responses is less clear. We examined variability and consistency of individual systolic blood pressure responses t ... Full text Link to item Cite

Effects of the Dietary Approaches to Stop Hypertension (DASH) diet on the pressure-natriuresis relationship.

Journal Article Hypertension · July 2003 Blood pressure-lowering mechanisms of the Dietary Approaches to Stop Hypertension (DASH) diet, rich in fruits, vegetables, and low-fat dairy foods, were analyzed based on the pressure-natriuresis relationship. Participants (n=375) were randomly assigned to ... Full text Link to item Cite

Premier: a clinical trial of comprehensive lifestyle modification for blood pressure control: rationale, design and baseline characteristics.

Journal Article Ann Epidemiol · July 2003 Featured Publication PURPOSE: To describe PREMIER, a randomized trial to determine the effects of multi-component lifestyle interventions on blood pressure (BP). METHODS: Participants with above optimal BP through stage 1 hypertension were randomized to: 1) a behavioral lifest ... Full text Link to item Cite

The DASH diet enhances the blood pressure response to losartan in hypertensive patients.

Journal Article Am J Hypertens · May 2003 BACKGROUND: The Dietary Approaches to Stop Hypertension (DASH) diet, which emphasizes fruits, vegetables, and low fat dairy products, significantly lowers blood pressure (BP). We conducted a clinical trial to assess the BP response to the DASH diet with an ... Full text Link to item Cite

Premier trial: BP effects of lifestyle interventions in subgroups

Conference American Journal of Hypertension · May 2003 Full text Cite

Effects of comprehensive lifestyle modification on blood pressure control: main results of the PREMIER clinical trial.

Journal Article JAMA · April 23, 2003 Featured Publication CONTEXT: Weight loss, sodium reduction, increased physical activity, and limited alcohol intake are established recommendations that reduce blood pressure (BP). The Dietary Approaches to Stop Hypertension (DASH) diet also lowers BP. To date, no trial has e ... Full text Link to item Cite

A new model for developing and executing culturally appropriate behavior modification clinical trials for African Americans.

Journal Article Ethn Dis · 2003 Featured Publication Past clinical trials addressing behavior modification for cardiovascular disease (CVD) prevention have not been culturally appropriate for African Americans. This supposition is borne out by the continued challenges researchers face not only in recruiting ... Link to item Cite

Effect of home monitoring on blood pressure and left ventricular hypertrophy in a hemodialysis cohort.

Journal Article JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY · September 1, 2002 Link to item Cite

Effects of the dietary approaches to stop hypertension (DASH) diet on pressure-natriuresis relationship.

Journal Article JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY · September 1, 2002 Link to item Cite

The impact of angiotensin II receptor blockade and the DASH diet on markers of endogenous fibrinolysis.

Journal Article J Hum Hypertens · June 2002 Hypertension is associated with impaired fibrinolysis. Both angiotensin receptor blockers (ARB) and the DASH (Dietary Approaches to Stop Hypertension) diet effectively lower blood pressure in hypertensive patients. Some evidence suggests that treatment wit ... Full text Link to item Cite

Diet- and blood pressure-related knowledge, attitudes, and hypertension prevalence among African Americans: The KDBP study

Journal Article Ethnicity and Disease · May 18, 2002 Despite attempts to raise awareness of the effect lifestyle factors such as diet have on health, little is known about the results of such efforts among populations at highest risk for hypertension (HTN). The Knowledge of Diet and Blood Pressure (KDBP) Stu ... Cite

Protease inhibitors are associated with a slowed progression of HIV-related renal diseases.

Journal Article Clin Nephrol · May 2002 AIMS: While angiotensin-con-verting enzyme inhibitors and zidovudine may improve the course of the most common HIV-related renal disease, HIV-associated nephropathy (HIVAN), the effect of anti-retroviral combination therapy on this and other HIV-related re ... Full text Link to item Cite

Church rosters: is this a viable mechanism for effectively recruiting African Americans for a community-based survey?

Journal Article Ethn Health · February 2002 Featured Publication OBJECTIVES: The purpose of this report is to describe the process, results, and implications in the phone recruitment of African Americans through church rosters for a survey of diet-and blood pressure-related awareness and hypertension prevalence. DESIGN: ... Full text Link to item Cite

A method of calibrating a radar station with measurements of the effective scattering area of targets over the sea

Journal Article Measurement Techniques · January 1, 2002 A method of calibrating a radar station by measuring the effective scattering area of marine targets was proposed. The effective scattering area of a calibrated reflector situated close to the interface of two media was also determined. The multibeam natur ... Full text Cite

Predictors of proteinuria and renal failure among women with HIV infection.

Journal Article Kidney Int · January 2002 BACKGROUND: Glomerular disease with proteinuria and renal failure are complications of human immunodeficiency virus (HIV) infection. While studies suggest risk factors for both include black race and lower CD4 lymphocyte count, they have not been establish ... Full text Link to item Cite

Diet- and blood pressure-related knowledge, attitudes, and hypertension prevalence among African Americans: the KDBP Study. Knowledge of Diet and Blood Pressure.

Journal Article Ethn Dis · 2002 Despite attempts to raise awareness of the effect lifestyle factors such as diet have on health, little is known about the results of such efforts among populations at highest risk for hypertension (HTN). The Knowledge of Diet and Blood Pressure (KDBP) Stu ... Link to item Cite

Effects of diet and sodium intake on blood pressure: subgroup analysis of the DASH-sodium trial.

Journal Article Ann Intern Med · December 18, 2001 BACKGROUND: Initial findings from the Dietary Approaches to Stop Hypertension (DASH)-Sodium Trial demonstrated that reduction of sodium intake in two different diets decreased blood pressure in participants with and without hypertension. OBJECTIVE: To dete ... Full text Link to item Cite

Angiotensinogen genotype and blood pressure response in the Dietary Approaches to Stop Hypertension (DASH) study.

Journal Article J Hypertens · November 2001 Featured Publication OBJECTIVE: To determine the relationship between angiotensinogen (ANG) genotype and blood pressure response to the dietary patterns of the Dietary Approaches to Stop Hypertension (DASH) trial. The angiotensin converting enzyme (ACE) gene was also tested. D ... Full text Link to item Cite

Variability in blood pressure response to salt intake

Journal Article CIRCULATION · October 23, 2001 Link to item Cite

DASH (Dietary Approaches to Stop Hypertension) diet is effective treatment for stage 1 isolated systolic hypertension.

Journal Article Hypertension · August 2001 Use of the DASH (Dietary Approaches to Stop Hypertension) diet, which is rich in fruits, vegetables, and low-fat dairy foods, significantly lowers blood pressure. Among the 459 participants in the DASH Trial, 72 had stage 1 isolated systolic hypertension ( ... Full text Link to item Cite

Dietary sodium and blood pressure.

Journal Article N Engl J Med · May 31, 2001 Link to item Cite

Dietary sodium and blood pressure. Reply

Journal Article NEW ENGLAND JOURNAL OF MEDICINE · May 31, 2001 Link to item Cite

Effects on blood pressure of reduced dietary sodium and the Dietary Approaches to Stop Hypertension (DASH) diet. DASH-Sodium Collaborative Research Group.

Journal Article N Engl J Med · January 4, 2001 Featured Publication BACKGROUND: The effect of dietary composition on blood pressure is a subject of public health importance. We studied the effect of different levels of dietary sodium, in conjunction with the Dietary Approaches to Stop Hypertension (DASH) diet, which is ric ... Full text Link to item Cite

New insights into the effects on blood pressure of diets low in salt and high in fruits and vegetables and low-fat dairy products.

Journal Article Curr Control Trials Cardiovasc Med · 2001 Results from the recent Dietary Approaches to Stop Hypertension (DASH)-Sodium trial provide the latest evidence concerning the effects of dietary patterns and sodium intake on blood pressure. Participants ate either the DASH diet (high in fruits, vegetable ... Full text Link to item Cite

The effect of dietary patterns on blood pressure control in hypertensive patients: results from the Dietary Approaches to Stop Hypertension (DASH) trial.

Journal Article Am J Hypertens · September 2000 To determine the impact of dietary patterns on the control of hypertension we studied the subgroup of 133 participants with systolic blood pressure (BP) of 140 to 159 mm Hg and/or diastolic BP of 90 to 95 mm Hg enrolled in the Dietary Approaches to Stop Hy ... Full text Link to item Cite

Genetic determinants of bp response to dash dietary patterns

Journal Article American Journal of Hypertension · June 2000 Full text Cite

Diagnosis and management of renovascular hypertension.

Journal Article Cardiol Rev · 2000 Renovascular hypertension caused by renal artery stenosis accounts for a small portion of overall hypertension but remains important as the most common potentially curable form of high blood pressure. Diagnosis depends on developing an index of suspicion f ... Full text Link to item Cite

Effects of prior exercise on eccentric exercise-induced neutrophilia and enzyme release

Journal Article Medicine and Science in Sports and Exercise · 2000 Purpose: The purpose of this study was to determine the effects of prior exercise on changes in circulating neutrophils, neutrophil activation, and myocellular enzymes following a standardized bout of eccentric exercise. Methods: Twenty-four male volunteer ... Cite

Effect of dietary patterns on ambulatory blood pressure : results from the Dietary Approaches to Stop Hypertension (DASH) Trial. DASH Collaborative Research Group.

Journal Article Hypertension · September 1999 We measured ambulatory blood pressure (ABP) in 354 participants in the Dietary Approaches to Stop Hypertension (DASH) Trial to determine the effect of dietary treatment on ABP (24-hour, day and night) and to assess participants' acceptance of and complianc ... Full text Link to item Cite

The effects of dietary patterns on quality of life: a substudy of the Dietary Approaches to Stop Hypertension trial.

Journal Article J Am Diet Assoc · August 1999 Few studies have examined the effects of dietary changes, particularly modifications of whole dietary patterns, on quality of life. The Dietary Approaches to Stop Hypertension (DASH) trial compared the effects of 3 dietary patterns on blood pressure. In th ... Full text Link to item Cite

Dietary Approaches to Stop Hypertension: rationale, design, and methods. DASH Collaborative Research Group.

Journal Article J Am Diet Assoc · August 1999 Epidemiologic studies across societies have shown consistent differences in blood pressure that appear to be related to diet. Vegetarian diets are consistently associated with reduced blood pressure in observational and interventional studies, but clinical ... Full text Link to item Cite

The DASH Diet, Sodium Intake and Blood Pressure Trial (DASH-sodium): rationale and design. DASH-Sodium Collaborative Research Group.

Journal Article J Am Diet Assoc · August 1999 The DASH Diet, Sodium Intake and Blood Pressure Trial (DASH-Sodium) is a multicenter, randomized trial comparing the effects of 3 levels of sodium intake and 2 dietary patterns on blood pressure among adults with higher than optimal blood pressure or with ... Full text Link to item Cite

A dietary approach to prevent hypertension: A review of the dietary approaches to stop hypertension (DASH) study

Journal Article Clinical Cardiology · July 14, 1999 Background: Populations eating mainly vegetarian diets have lower blood pressure levels than those eating omnivorous diets. Epidemiologic findings suggest that eating fruits and vegetables lowers blood pressure. Hypothesis: Two hypotheses were tested: (1) ... Cite

A dietary approach to prevent hypertension: a review of the Dietary Approaches to Stop Hypertension (DASH) Study.

Journal Article Clin Cardiol · July 1999 BACKGROUND: Populations eating mainly vegetarian diets have lower blood pressure levels than those eating omnivorous diets. Epidemiologic findings suggest that eating fruits and vegetables lowers blood pressure. HYPOTHESIS: Two hypotheses were tested: (1) ... Full text Link to item Cite

Effects of dietary patterns on blood pressure: subgroup analysis of the Dietary Approaches to Stop Hypertension (DASH) randomized clinical trial.

Journal Article Arch Intern Med · February 8, 1999 Featured Publication OBJECTIVE: To determine the effects of dietary patterns on blood pressure in subgroups. METHODS: Dietary Approaches to Stop Hypertension (DASH) was a randomized controlled feeding study conducted at 4 academic medical centers. Participants were 459 adults ... Full text Link to item Cite

Recruitment and retention of minority participants in the DASH controlled feeding trial

Journal Article Ethnicity and Disease · December 1, 1998 The Dietary Approaches to Stop Hypertension (DASH) study was a National Heart, Lung, and Blood Institute multicenter trial that compared the impact of three dietary patterns on blood pressure (BP) among adults with high normal blood pressure or mild (Stage ... Cite

More salt, please [5] (multiple letters)

Journal Article Science · November 6, 1998 Cite

More salt, please

Journal Article SCIENCE · November 6, 1998 Link to item Cite

Free pentosidine and neopterin as markers of progression rate in diabetic nephropathy. Collaborative Study Group.

Journal Article Kidney Int · July 1998 BACKGROUND: Patients with diabetic nephropathy experience a progressive and usually inexorable decline in renal function. The presence of the structurally defined advanced glycation end product (AGE) pentosidine on tissue and circulating proteins has been ... Full text Link to item Cite

A randomized, double-blind, placebo-controlled, parallel-group, multicenter trial of four doses of tasosartan in patients with essential hypertension. Tasosartan Investigator's Group.

Journal Article Am J Hypertens · April 1998 Tasosartan, a new, long-acting, nonpeptide angiotensin II receptor antagonist was evaluated in a randomized, double-blind, placebo-controlled, multicenter trial at 21 sites in the United States and Canada. After a 2-week, placebo washout qualification peri ... Full text Link to item Cite

Knowledge of diet and blood pressure among African Americans: use of focus groups for questionnaire development.

Journal Article Ethn Dis · 1998 Though focus groups are widely used for development of interventions, little is known about their utility in questionnaire construction, particularly for health surveys in a south-eastern African-American population. In this study, focus groups aided in th ... Link to item Cite

Recruitment and retention of minority participants in the DASH controlled feeding trial. DASH Collaborative Research Group. Dietary Approaches to Stop Hypertension.

Journal Article Ethn Dis · 1998 The Dietary Approaches to Stop Hypertension (DASH) study was a National Heart, Lung, and Blood Institute multicenter trial that compared the impact of three dietary patterns on blood pressure (BP) among adults with high normal blood pressure or mild (Stage ... Link to item Cite

Renal TGF-beta in HIV-associated kidney diseases.

Journal Article Kidney Int · May 1997 Human immunodeficiency virus (HIV)-1 infection may be complicated by progressive renal glomerular disease, including focal segmental glomerulosclerosis (FSGS) and proliferative glomerulonephritis. We examined renal tissue from 71 patients, including biopsi ... Full text Link to item Cite

A clinical trial of the effects of dietary patterns on blood pressure. DASH Collaborative Research Group.

Journal Article N Engl J Med · April 17, 1997 BACKGROUND: It is known that obesity, sodium intake, and alcohol consumption factors influence blood pressure. In this clinical trial, Dietary Approaches to Stop Hypertension, we assessed the effects of dietary patterns on blood pressure. METHODS: We enrol ... Full text Link to item Cite

Preliminary evidence of linkage of salt sensitivity in black Americans at the beta 2-adrenergic receptor locus.

Journal Article Hypertension · April 1997 Salt sensitivity is a heritable trait that is a hallmark of hypertension in black Americans. Genes encoding adrenergic receptors are candidate loci for the inheritance of this hypertension-related trait because of the role of these receptors in the regulat ... Full text Link to item Cite

Heritability of salt sensitivity in black Americans.

Journal Article Hypertension · November 1996 Salt sensitivity is defined as a change in blood pressure in response to changes in salt and water homeostasis. Found in 73% of hypertensive and 36% of normotensive blacks, it is generally considered a hallmark of hypertension in blacks. The higher prevale ... Full text Link to item Cite

Association of hypertension with beta2- and alpha2c10-adrenergic receptor genotype.

Journal Article Hypertension · June 1996 The adrenergic receptors have been implicated in the pathogenesis of essential hypertension. We hypothesized that hypertension is associated with variants at the beta2-adrenergic receptor locus and at one of the alpha2-adrenergic receptor loci. In unrelate ... Full text Link to item Cite

Effects of gender and ethnic group on blood pressure control in the elderly.

Journal Article Am J Hypertens · June 1996 In order to determine the adequacy of blood pressure treatment in black and white elderly men and women, the authors performed a cross-sectional population survey in Central North Carolina in 1986-1987. Participants included a random sample of noninstituti ... Full text Link to item Cite

Renovascular hypertension in blacks.

Journal Article Am J Hypertens · January 1996 To define the clinical characteristics of renovascular hypertension (RVH) and determine the clinical usefulness of captopril stimulated peripheral renin and postcaptopril renography in blacks at risk for RVH, 79 clinically selected hypertensive blacks were ... Full text Link to item Cite

Rationale and design of the Dietary Approaches to Stop Hypertension trial (DASH). A multicenter controlled-feeding study of dietary patterns to lower blood pressure.

Journal Article Ann Epidemiol · March 1995 Epidemiologic studies have found that dietary patterns characterized by high intakes of certain minerals and fiber are associated with low blood pressure. Dietary Approaches to Stop Hypertension (DASH) is a multicenter, randomized, controlled-feeding trial ... Full text Link to item Cite

Doppler evaluation of renal artery stenosis: interobserver agreement in the interpretation of waveform morphology.

Journal Article AJR Am J Roentgenol · June 1994 OBJECTIVE: Analysis of Doppler waveform morphology for features of the tardus-parvus phenomenon has been promoted as a useful and accurate means for detecting renal artery stenosis. The purpose of this study was to examine and quantify the interobserver ag ... Full text Link to item Cite

Renal artery stenosis: analysis of Doppler waveform parameters and tardus-parvus pattern.

Journal Article Radiology · December 1993 PURPOSE: The utility of Doppler parameters and waveform contour analysis for diagnosis of renal artery stenosis was studied in a hypertensive population screened for renovascular hypertension. MATERIALS AND METHODS: The Doppler results were compared with t ... Full text Link to item Cite

Effect of low-dose aspirin on thromboxane production and the antihypertensive effect of captopril.

Journal Article J Am Soc Nephrol · November 1993 Some of the antihypertensive effects of angiotensin-converting enzyme (ACE) inhibitors occur through nonangiotensin II-mediated mechanisms. One of these is through decreased kinin degradation, leading to enhanced production of vasodilator arachidonic acid ... Full text Link to item Cite

Black/white differences in hypertension in the elderly: an epidemiologic analysis in central North Carolina.

Journal Article Am J Epidemiol · January 1, 1993 Hypertension in blacks, compared with whites, occurs at higher prevalence rates, is more severe, and carries a worse prognosis for cardiovascular morbidity and mortality. The authors examined the degree to which black/white differences in hypertension in t ... Full text Link to item Cite

A controlled clinical trial of angiotensin-converting enzyme inhibition in type I diabetic nephropathy: study design and patient characteristics. The Collaborative Study Group.

Journal Article J Am Soc Nephrol · October 1992 A placebo-controlled, double-blind clinical trial has been initiated to determine whether angiotensin-converting enzyme inhibitor (ACEI) therapy with captopril (25 mg three times daily) slows the progressive loss of renal function in patients with type 1 d ... Full text Link to item Cite

Potassium chloride lowers blood pressure and causes natriuresis in older patients with hypertension.

Journal Article J Am Soc Nephrol · February 1992 Epidemiologic surveys, experimental studies in animals, and clinical trials in young and middle-aged patients with hypertension indicate that dietary potassium lowers blood pressure. The mechanism of the antihypertensive effect is not well defined. Variati ... Full text Link to item Cite

Report of the Working Party Group for Patient Selection and Preparation.

Journal Article Am J Hypertens · December 1991 Captopril renography is a valuable test in the diagnosis of patients with renal artery stenosis. We examined the criteria for selecting patients for this procedure and the best methods for preparing the patient for renography. ... Full text Link to item Cite

Captopril renography in the diagnosis of renovascular disease.

Journal Article Am J Hypertens · December 1991 Several investigators have reported methods for the use of renal scintigraphy in the diagnosis of renal artery stenosis. We report the experience of Duke University Medical Center, and offer some suggestions for standardizing and optimizing the use of this ... Full text Link to item Cite

Racial differences in the incidence and progression of renal diseases.

Journal Article Kidney Int · November 1991 There is an excess incidence of ESRD treatment among non-White North Americans that is not completely explained by the racial prevalences of the underlying diseases, including hypertension, which can potentially cause renal disease. The racial difference i ... Full text Link to item Cite

Imaging of the renal arteries: value of MR angiography.

Journal Article AJR Am J Roentgenol · November 1991 We compared the efficacy of MR angiography with that of conventional angiography for visualizing the renal arteries and detecting renovascular disease. Thirty-three MR angiographic studies, consisting of axial two-dimensional (2-D) phase-contrast, coronal ... Full text Link to item Cite

Similar prevalence of renovascular hypertension in selected blacks and whites.

Journal Article Hypertension · May 1991 Renovascular hypertension is a potentially curable form of high blood pressure that is thought to be extremely rare among blacks. We demonstrate, however, that in a clinically selected population, the prevalence of renovascular hypertension is similar in b ... Full text Link to item Cite

Renal vein renins: inability to predict response to revascularization in patients with hypertension.

Journal Article Radiology · March 1991 To determine whether the captopril-stimulated renal vein renin ratio (CSRVRR) could enable identification of patients with hemodynamically significant renovascular lesions who would respond to revascularization, the authors measured CSRVRRs in 143 consecut ... Full text Link to item Cite

Report on the working party group for patient selection and preparation

Journal Article American Journal of Hypertension · 1991 Captopril renography is a valuable test in the diagnosis of patients with renal artery stenosis. We examined the criteria for selecting patients for this procedure and the best methods for preparing the patient for renography. ... Cite

Clinical characteristics useful in screening for renovascular disease.

Journal Article South Med J · July 1990 In an effort to detect renovascular hypertension, clinical characteristics are used to select patients likely to have renal artery stenosis. We prospectively evaluated the ability of commonly used clinical features to predict the presence of renal artery s ... Full text Link to item Cite

Evaluation of the clinical pharmacology of nilvadipine in patients with mild to moderate essential hypertension.

Journal Article J Clin Pharmacol · May 1990 Eighty-four patients with diastolic blood pressure ranging from 100-115 mm Hg were randomized into a multicenter, parallel, double-blind, placebo-controlled, dose response study with nilvadipine (6 mg, 8 mg, 10 mg tid for 28 days). The hypotensive response ... Full text Link to item Cite

Prospective analysis of strategies for diagnosing renovascular hypertension.

Journal Article Hypertension · September 1989 Renovascular hypertension is a potentially curable form of high blood pressure. However, it is unclear how best to select patients who are likely to have renovascular hypertension, what diagnostic strategy to use in these selected patients, and how to pred ... Full text Link to item Cite

Intravenous digital subtraction renal angiography: use in screening for renovascular hypertension.

Journal Article Radiology · April 1989 Intravenous digital subtraction renal angiography (DSRA) has been compared with conventional angiography only in small, selected series of hypertensive patients. The authors prospectively examined with intravenous DSRA 94 patients at increased risk for ren ... Full text Link to item Cite

Comparison of intravenous digital subtraction angiography and conventional arteriography in defining renal anatomy.

Journal Article Transplantation · January 1988 Intravenous digital subtraction renal angiography (IV-DSRA) is frequently used in the preoperative evaluation of living-related (LR) kidney donors. However, the true accuracy of IV-DSRA in the donor population is difficult to assess since abnormalities of ... Full text Link to item Cite

Double-blind comparison of doxazosin, nadolol, and placebo in patients with mild-to-moderate hypertension

Journal Article Current Therapeutic Research - Clinical and Experimental · January 1, 1988 Doxazosin, an alpha1-adrenergic receptor antagonist, is a new once-a-day antihypertensive agent. In a multicenter, double-blind study, we compared doxazosin to the beta-adrenergic antagonist nadolol and to placebo. Ambulatory adults were eligible if diasto ... Cite

Double-blind, placebo-controlled trial of twice-daily nifedipine as a step-2 agent in mild essential hypertension.

Journal Article J Clin Hypertens · December 1987 Nifedipine is a calcium-channel blocker that produces vasodilatation and decreased peripheral resistance in humans. Several clinical reports document blood-pressure-lowering effects of nifedipine with either acute or chronic administration. Little data are ... Link to item Cite

Double-blind, placebo-controlled trial of potassium chloride in the treatment of mild hypertension.

Journal Article Hypertension · May 1987 Epidemiological and experimental data suggest blood pressure-lowering effects of dietary potassium. A randomized, double-blind clinical trial was used to assess blood pressure response to orally administered potassium, 120 mEq/day, and to placebo in 101 ad ... Full text Link to item Cite

Observer variability in the pulmonary examination.

Journal Article J Gen Intern Med · 1986 Observer variability in the pulmonary examination was assessed by having four blindfolded observers (two medical students and two pulmonary physicians) twice examine 31 patients with abnormal pulmonary findings. Examiners were consistent in the repetitive ... Full text Link to item Cite

Sustained-release trimazosin in the treatment of mild-to-moderate hypertension

Journal Article Current Therapeutic Research - Clinical and Experimental · January 1, 1986 The efficacy and duration of action of the direct-acting vasodilator trimazosin in a sustained-release (SR) formulation was investigated in 59 adults with mild-to-moderate hypertension. Average systolic and diastolic blood pressures before treatment were 1 ... Cite

A chronically red eye.

Journal Article N C Med J · October 1983 Link to item Cite

Perception of Obesity in the Latino Population: Implications for Weight Loss Clinical Trials.

Journal Article ABNF J Ethnic minorities in the United States have a higher prevalence of obesity, with higher levels reported in Latinos/Hispanics. A qualitative study was done to understand perceptions of obesity and identify factors that may enhance the attractiveness of a be ... Link to item Cite