Scholars@Duke
Thomas William LeBlanc

Thomas William LeBlanc

Associate Professor of Medicine
Medicine, Hematologic Malignancies and Cellular Therapy
thomas.leblanc@duke.edu
Box 2715, DUMC, Durham, NC 27710
2424 Erwin Road, Suite 602, Durham, NC 27705

Selected Publications

Present challenges impacting the management of psychological symptoms in patients receiving CAR-T therapy or stem cell transplantation.

Journal Article Expert Rev Pharmacoecon Outcomes Res · December 2025 INTRODUCTION: Hematopoietic stem cell (HSCT) and chimeric antigen receptor T-cell (CAR-T) therapy are crucial in the treatment of hematologic malignancies. While HSCT has been long established as a mainstay of the treatment of these diseases, CAR-T is a ne ... Full text Link to item Cite

Palliative Care Integration in Oncology: A Review and Update.

Journal Article Journal of hospice and palliative care · December 2025 Palliative care (PC) is increasingly recognized as an essential component of high-quality cancer care, with evidence from randomized trials and meta-analyses demonstrating that it improves quality of life, mood, and goal-concordant end-of-life care. Despit ... Full text Cite

Physician Characteristics Associated With Advance Care Planning After a Machine Learning-Based Nudge.

Journal Article Am J Hosp Palliat Care · November 21, 2025 Prognostic machine learning models can help identify patients in need of advance care planning (ACP) conversations. However, additional work is needed to understand which factors guide physicians' comfort with and prioritization of ACP conversations, even ... Full text Link to item Cite

A modelled cost-utility analysis comparing early referral to specialist palliative care versus standard care for older people with acute myeloid leukaemia.

Journal Article Support Care Cancer · November 17, 2025 AIM: To investigate whether early referral to specialist palliative care (SPC) is cost-effective compared to standard care for people ≥ 60 years of age with newly diagnosed acute myeloid leukaemia (AML). METHODS: A modelled cost-utility analysis, from an A ... Full text Link to item Cite

Ivosidenib or venetoclax combined with hypomethylating agents in IDH1-mutated acute myeloid leukemia: a real-world study.

Journal Article Blood Neoplasia · November 2025 Approximately 10% of patients with newly diagnosed acute myeloid leukemia (ND-AML) harbor the isocitrate dehydrogenase 1 gene mutation (mIDH1). In this real-world study evaluating ivosidenib (IVO) + hypomethylating agents (HMAs; n = 181) vs venetoclax (VEN ... Full text Link to item Cite

Palliative care use and end-of-life care quality in HR+/HER2- metastatic breast cancer.

Journal Article Breast Cancer Res Treat · November 2025 PURPOSE: Metastatic breast cancer (MBC) is incurable, despite therapeutic advances, especially in hormone receptor positive (HR+) and human epidermal growth factor-2 negative (HER2-) disease. Specialist palliative care (SPC) is recommended to alleviate dis ... Full text Link to item Cite

Using Natural Language Processing to Assess Goals-of-Care Conversations for Patients With Cancer.

Conference JCO Clin Cancer Inform · October 2025 PURPOSE: Goals-of-care (GOC) discussions during advanced serious illness and end-of-life (EOL) care are critical. Institutions are increasingly tracking the frequency and timing of GOC documentation, but large-scale content assessments have been limited. W ... Full text Link to item Cite

Prolonged Hospitalization for Hematopoietic Cell Transplantation: Characteristics, Risk Factors and Associations with Patient-Reported and Clinical Outcomes.

Journal Article Transplant Cell Ther · September 2025 Patients hospitalized for hematopoietic cell transplantation (HCT) may experience prolonged length of stay (PLOS). However, the associations between PLOS and patient-reported outcomes (PROs) during and after HCT hospitalization is unknown. We aimed to eval ... Full text Link to item Cite

Multisite Randomized Trial of Inpatient Palliative Care Intervention for Patients Undergoing Hematopoietic Stem Cell Transplantation.

Journal Article J Clin Oncol · August 20, 2025 PURPOSE: Patients undergoing hematopoietic stem cell transplantation (HSCT) and their caregivers endure immense physical and psychological symptoms, which result in quality-of-life (QOL) impairments during HSCT. METHODS: We conducted a multisite randomized ... Full text Link to item Cite

Treatment Patterns, Efficacy, and Tolerability of Belantamab Mafodotin in Patients With Relapsed and/or Refractory Multiple Myeloma: A Real-World Analysis.

Journal Article Clin Lymphoma Myeloma Leuk · August 2025 PURPOSE: Belantamab mafodotin is an anti-B cell maturation antigen (BCMA) immunoconjugate for patients with relapsed/refractory multiple myeloma (RRMM). Additional data on its treatment patterns, efficacy, and tolerability in real-world settings are needed ... Full text Link to item Cite

Early Specialist Palliative Care in Patients with Metastatic Cancer: A Population-Based Cohort Study.

Journal Article J Pain Symptom Manage · August 2025 CONTEXT: Although early integration of specialist palliative care (PC) is recommended for patients with advanced cancer, how frequently these guidelines are followed is unknown. OBJECTIVE: To examine use of early PC in real-world settings. METHODS: Retrosp ... Full text Link to item Cite

What do pediatric transplant physicians think about palliative care? Results from a national survey study.

Journal Article Bone Marrow Transplant · August 2025 The benefits of palliative care (PC) for hematopoietic cell transplant (HCT) patients are well established, however, uptake in pediatric HCT remains limited. To understand pediatric transplant physicians' attitudes towards PC, we conducted a cross-sectiona ... Full text Link to item Cite

Examining the Experience and Preferences of Patients with Advanced Cancer at a Tertiary Care Center.

Journal Article J Palliat Med · August 2025 Background and Objectives: Cancer care has been transformed with the advent of new personalized and targeted therapies, and the integration of specialist palliative care (PC). Comparatively little is understood about the patient experience in this modern c ... Full text Link to item Cite

Real-world analysis of strategies to prevent thrombosis and bleeding in adults with ALL treated with asparaginase.

Journal Article Blood Vessel Thromb Hemost · August 2025 The prognosis of adult patients with acute lymphoblastic leukemia (ALL) has improved with the incorporation of pediatric-inspired regimens that contain PEGylated asparaginase (PEG-Asp). However, PEG-Asp administration is associated with an increased rate o ... Full text Link to item Cite

Quantifying Preferences for CAR-T Compared to Standard of Care as a First-Line Treatment Among Patients With Multiple Myeloma.

Journal Article Cancer Med · July 2025 BACKGROUND: CAR-T therapy is approved for the treatment of relapsed refractory multiple myeloma (MM) and is being studied for newly diagnosed MM (NDMM). The use of novel therapies in early-line MM raises questions on the acceptability of upfront risks in e ... Full text Link to item Cite

Abstract P2-01-13: Palliative Care Use and End-of-Life Care Quality in HR+/HER2- Metastatic Breast Cancer

Conference Clinical Cancer Research · June 13, 2025 AbstractBackground: Metastatic breast cancer (MBC) is incurable, but therapeutic advances have improved clinical outcomes for patients with hormone receptor positive (HR+), human epidermal growth factor-2 ne ... Full text Cite

Unmet needs and lived experience of patients receiving CAR T-cell therapy.

Journal Article Leuk Lymphoma · June 2025 Chimeric Antigen Receptor T-Cell (CAR-T) therapy is an effective therapy and promising frontier in the treatment of hematologic malignancies. However, this revolutionary treatment has led to new challenges for patients, caregivers, and the healthcare syste ... Full text Link to item Cite

Factors associated with early quality-of-life response to palliative care during hematopoietic cell transplantation.

Journal Article Blood Adv · May 13, 2025 Limited data exist on factors associated with early quality-of-life (QOL) response to palliative care (PC) in patients undergoing hematopoietic cell transplantation (HCT). We conducted a secondary analysis from 2 randomized clinical trials of PC vs usual c ... Full text Link to item Cite

Elranatamab versus physician's choice of treatment in patients with triple-class exposed/refractory multiple myeloma: an updated matching-adjusted indirect comparison.

Journal Article J Comp Eff Res · May 2025 Aim: Despite the availability of novel treatment options for patients with triple-class exposed/refractory multiple myeloma , there is a lack of consensus on the optimal regimen. A previous unanchored matching-adjusted indirect comparison (MAIC) of the Mag ... Full text Link to item Cite

Quality for All: Clinical Trial Enrollment and End-of-Life Care in Solid and Hematologic Malignancies.

Journal Article Cancer Med · May 2025 BACKGROUND: Patients with incurable cancer deserve quality end-of-life (EOL) care. Despite established EOL quality metrics, many patients receive aggressive EOL care with limited goals of care (GOC) documentation. Concurrently, clinical trials are critical ... Full text Link to item Cite

Implementation of a Novel Pathway to Integrate Palliative and Oncology Care for Patients With Acute Myeloid Leukemia in a Community Hospital.

Journal Article JCO Oncol Pract · April 2025 PURPOSE: Historically, patients with hematologic malignancies are referred to palliative care less often and later in the disease trajectory than those with solid tumors. Recent evidence demonstrates the benefit of early, integrated inpatient palliative ca ... Full text Link to item Cite

Correction.

Journal Article Future Oncol · April 2025 Full text Link to item Cite

Increasing Advance Care Planning Discussions and Documentation.

Journal Article J Adv Pract Oncol · March 16, 2025 BACKGROUND: Advance care planning (ACP) is an important aspect of care for the oncology patient population, leading to improved outcomes, less aggressive care toward the end of life, and reduced costs. PURPOSE: The objective of this project was to increase ... Full text Link to item Cite

Evaluation of Gemtuzumab Ozogamicin and Anthracycline Dosing for Favorable Risk Acute Myeloid Leukemia.

Journal Article Eur J Haematol · March 2025 Gemtuzumab ozogamicin (GO) is a CD33-targeting antibody-drug conjugate approved for the treatment of CD33-positive de novo and relapsed and refractory acute myeloid leukemia (AML). Subset analyses have demonstrated improved clinical outcomes in patients wi ... Full text Link to item Cite

Recalling what we thought we knew about recall periods: a qualitative descriptive study of how adults diagnosed with cancer use recall periods for patient-reported outcome items about physical function.

Journal Article Qual Life Res · March 2025 OBJECTIVES: In cancer studies, assessment of patients' physical function can provide insight into cancer-related symptoms and the side effects of treatment. Physical function can be assessed using patient-reported outcome measures (PROMs), which may or may ... Full text Open Access Link to item Cite

Top Ten Tips Palliative Care Clinicians Should Know About Caring for Patients with Myeloproliferative Neoplasms.

Journal Article J Palliat Med · February 2025 Myeloproliferative neoplasms (MPNs) are a group of rare chronic progressive blood cancers that vary widely in clinical presentation, yet all patients have a risk of disease progression and thrombotic complications. Diseases include primary myelofibrosis, p ... Full text Link to item Cite

Multiple Myeloma Experiences and Preferences: A Mixed Methods Study of Patients and Care Partners in the United States.

Journal Article Patient Prefer Adherence · 2025 PURPOSE: Multiple myeloma (MM) is characterized by treatment relapse and resistance, requiring sequential treatment decisions throughout its course. To understand how disease status and an evolving treatment landscape impact decisions made by patients and ... Full text Link to item Cite

Matching-Adjusted Indirect Comparison of Elranatamab versus Teclistamab in Patients with Triple-Class Exposed/Refractory Multiple Myeloma: Updated Results.

Journal Article J Blood Med · 2025 BACKGROUND: Due to the absence of a head-to-head trial directly comparing elranatamab and teclistamab in triple-class exposed/refractory multiple myeloma (TCE/R MM), a matching-adjusted indirect treatment comparison (MAIC) was previously conducted. The aim ... Full text Link to item Cite

An Updated Indirect Comparison of Elranatamab Versus a Real-World External Control Arm in Triple-Class Refractory Multiple Myeloma.

Journal Article Blood Lymphat Cancer · 2025 PURPOSE: Elranatamab is a BCMAxCD3 bispecific antibody approved for the treatment of relapsed/refractory multiple myeloma (RRMM). The registrational Phase 2 MagnetisMM-3 (NCT04649359) trial was single-armed; the aim of this indirect comparison was to conte ... Full text Link to item Cite

Treatment of Relapsed/Refractory t(11;14) Multiple Myeloma and High-Risk Myelodysplastic Syndrome With Venetoclax.

Journal Article Case Rep Hematol · 2025 Patients with multiple myeloma (MM) have an inherent risk for secondary myeloid malignancies. Innovative approaches to treatment are needed when these hematologic malignancies co-occur. Venetoclax (VEN), a BCL2 inhibitor, has been used in combination with ... Full text Link to item Cite

Updates on strategies to integrate palliative care in hematologic malignancy.

Journal Article Hematology Am Soc Hematol Educ Program · December 6, 2024 Full text Link to item Cite

Machine Learning for Targeted Advance Care Planning in Cancer Patients: A Quality Improvement Study.

Journal Article J Pain Symptom Manage · December 2024 CONTEXT: Prognostication challenges contribute to delays in advance care planning (ACP) for patients with cancer near the end of life (EOL). OBJECTIVES: Examine a quality improvement mortality prediction algorithm intervention's impact on ACP documentation ... Full text Link to item Cite

The impact of language discordance on pediatric cancer care outcomes: A systematic review.

Journal Article Pediatr Blood Cancer · December 2024 Language discordance between clinicians and families in pediatrics has been associated with adverse events and lower quality of care. We aimed to summarize the existing literature evaluating the impact of language discordance among healthcare professionals ... Full text Link to item Cite

Quality of end-of-life care in patients with hematological malignancies: potential role of palliative care.

Journal Article Support Care Cancer · November 28, 2024 BACKGROUND: Limited data are available on the impact of specialist palliative care on end-of-life care quality for patients with hematologic malignancies. This study aims to analyze the quality of end-of-life care in patients with hematological malignancie ... Full text Link to item Cite

Symptom experience of patients undergoing treatment for multiple myeloma: a longitudinal real-world electronic patient-reported outcomes study.

Journal Article Support Care Cancer · November 18, 2024 PURPOSE: Patients with multiple myeloma (MM) experience significant symptom burden. We used a symptom monitoring app to longitudinally characterize the MM treatment experience in detail based on line of therapy (LOT). METHODS: Adults with MM on active trea ... Full text Link to item Cite

Understanding Sociodemographic Barriers in Hematopoietic Stem Cell Transplantation Among Patients with Hematologic Malignancies: Insights from a North Carolina Cohort

Conference Blood · November 5, 2024 Background: Hematopoietic Stem Cell Transplantation (HCT) is a life-saving treatment for many patients with hematologic malignancies. Disparities persist across the transplant continuum. ... Full text Cite

Perceptions of Treatment Tolerability and Its Relationship to Income in Patients with Hematologic Malignancy: Findings from the Cancer Experience Registry

Conference Blood · November 5, 2024 Background: Hematologic malignancies (HM) often require therapies associated with a range of bothersome symptoms, side effects, and impacts. Clinical researchers typically consider tolera ... Full text Cite

Treatment Experience of Patients with Acute Myeloid Leukemia in the Era of Novel Therapies: A Longitudinal Electronic Patient-Reported Outcomes Study

Conference Blood · November 5, 2024 Background: Since 2017, novel therapies for acute myeloid leukemia (AML) have emerged as options for patients unfit for high-intensity induction chemotherapy. However, much of our current ... Full text Cite

Updated Results of a Matching-Adjusted Indirect Comparison of Elranatamab Versus Physician's Choice of Treatment in Patients with Triple-Class Exposed/Refractory Multiple Myeloma

Conference Blood · November 5, 2024 IntroductionFor patients with triple-class exposed multiple myeloma (TCE MM), the prognosis is poor, and limited effective treatment options are availa ... Full text Cite

An Indirect Comparison of Elranatamab's Progression-Free Survival, Duration of Response, and Overall Survival from MagnetisMM-3 Versus Real-World External Control Arms in Triple-Class Refractory Multiple Myeloma

Conference Blood · November 5, 2024 BACKGROUNDElranatamab(ELRA) is a BCMAxCD3 bispecific antibody approved for the treatment of relapsed/refractory multiple myeloma (MM) in the United Sta ... Full text Cite

Disparities in CAR-T Therapy Access and Outcomes: Variation in Referral Patterns for CAR-T Therapy in Patients with Newly Diagnosed Malignancies at an Academic Center in North Carolina

Conference Blood · November 5, 2024 Introduction: Chimeric Antigen Receptor (CAR)- T cell therapy has revolutionized the treatment of hematologic malignancies. However, access to CAR-T therapy remains limited, especially fo ... Full text Cite

Outcomes By Frailty in IC-Ineligible Newly Diagnosed AML - a Real-World Evidence Comparison By Treatment with Hypomethylating Agents + Ivosidenib or Venetoclax

Conference Blood · November 5, 2024 BACKGROUND:Nearly 50% of newly diagnosed (nd) patients with AML are ineligible for intensive chemotherapy (ICi) and are commonly referred to as “unfit” ... Full text Cite

Factors Associated with Early Quality of Life Response to Palliative Care during Hematopoietic Cell Transplantation

Conference Blood · November 5, 2024 Background: Integrated specialty palliative care (PC) during hematopoietic cell transplantation (HCT) improves quality of life (QOL) and reduces physical and psychological symptom burden ... Full text Cite

Multi-Site Randomized Trial of a Collaborative Palliative and Oncology Care Model for Patients with Acute Myeloid Leukemia (AML) and Myelodysplastic Syndrome (MDS) Receiving Non-Intensive Therapy

Conference Blood · November 5, 2024 Background:Patients with AML and high-risk MDS receiving non-intensive chemotherapy have substantial quality of life (QOL) impairments and often do not ... Full text Cite

Pre-Transplant Patient-Reported Outcomes Are Associated with Health Care Utilization and Transplant-Related Complications at One-Year Post-Transplant

Conference Blood · November 5, 2024 Background: Hematopoietic cell transplantation (HCT) is a potentially curative therapy for patients with many hematologic conditions but is often associated with early- and long-term comp ... Full text Cite

Updated Results of a Matching-Adjusted Indirect Comparison of Elranatamab Versus Teclistamab in Patients with Triple-Class Exposed/Refractory Multiple Myeloma

Conference Blood · November 5, 2024 IntroductionElranatamab (ELRA) is a BCMAxCD3 bispecific antibody approved for the treatment of relapsed refractory multiple myeloma (RRMM) based on the ... Full text Cite

Experienced or Perceived Burdens and Associated Quality of Life Impacts of Anemia and Transfusion Dependence in Myelofibrosis: A Patient Self-Report Survey Analysis

Conference Blood · November 5, 2024 Background: Myelofibrosis (MF) is associated with debilitating symptoms, which often negatively impact patients' health-related quality of life (QOL) and functioning. While Janus kinase ( ... Full text Cite

The Impact of Multiple Myeloma on Care Partner Well-Being, Work Productivity, and Resource Use in the United States and Western Europe

Conference Blood · November 5, 2024 BACKGROUNDThe impact of multiple myeloma (MM) extends beyond the affected patients themselves as care partners and family members also experience signi ... Full text Cite

A systematic review of health state utility values for older people with acute myeloid leukaemia.

Journal Article Qual Life Res · November 2024 PURPOSE: Older people with acute myeloid leukaemia (AML) have a poor prognosis, reduced health-related quality of life (HRQoL) and require substantial healthcare resources. The objectives of this systematic review were to determine what health state utilit ... Full text Link to item Cite

Timing of Palliative Care Consultation Impacts End of Life Care Outcomes in Metastatic Non-Small Cell Lung Cancer.

Journal Article J Pain Symptom Manage · October 2024 CONTEXT: Early specialist palliative care (PC) involvement in metastatic non-small cell lung cancer (mNSCLC) is associated with improved quality of life, less aggressive end of life (EoL) care, and longer survival. As treatment paradigms for NSCLC have evo ... Full text Link to item Cite

Pilot Testing of Build StaMINA: A Tailored Physical Activity Program for Adults Receiving Treatment for Acute Myeloid Leukemia.

Journal Article Cancer Nurs · September 27, 2024 BACKGROUND: Acute myeloid leukemia (AML) is an aggressive and often debilitating cancer for adults across the treatment trajectory. Patients experience frequent hospitalization, sedentariness, and negative sequelae including physical dysfunction and sympto ... Full text Link to item Cite

How do patients interpret and respond to a novel patient-reported eastern cooperative oncology group performance status (ECOG)?

Journal Article Qual Life Res · September 2024 PURPOSE: Performance status is an important concept in oncology, but is typically clinician-reported. Efforts are underway to include patient-reported measures in cancer care, which may improve patient symptoms, quality of life and overall survival. The pu ... Full text Open Access Link to item Cite

Stepped Palliative Care for Patients With Advanced Lung Cancer: A Randomized Clinical Trial.

Journal Article JAMA · August 13, 2024 IMPORTANCE: Despite the evidence for early palliative care improving outcomes, it has not been widely implemented in part due to palliative care workforce limitations. OBJECTIVE: To evaluate a stepped-care model to deliver less resource-intensive and more ... Full text Link to item Cite

Facets of physical function assessed by patient-reported outcome measures in oncology research.

Journal Article Qual Life Res · July 2024 PURPOSE: The U.S. Food & Drug Administration has identified physical functioning (PF) as a core patient-reported outcome (PRO) in cancer clinical trials. The purpose of this study was to identify PF PRO measures (PROMs) in adult cancer populations and clas ... Full text Open Access Link to item Cite

What facets of physical function are most important to adults diagnosed with cancer?

Journal Article Qual Life Res · July 2024 PURPOSE: Successful patient-focused drug development involves selecting and measuring outcomes in clinical trials that are important to patients. The U.S. Food & Drug Administration's definition of clinical benefit includes how patients feel, function, or ... Full text Link to item Cite

Multi-site randomized trial of a collaborative palliative and oncology care model for patients with acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) receiving non-intensive therapy.

Journal Article Journal of Clinical Oncology · June 10, 2024 LBA6508 Background: Patients with AML and high-risk MDS receiving non-intensive chemotherapy have substantial quality of life (QOL) impairments and often do not engage in timely discussions with their clinicians about their end-o ... Full text Cite

Top Ten Tips Palliative Care Clinicians Should Know About Acute Myeloid Leukemia.

Journal Article J Palliat Med · June 2024 Acute myeloid leukemia (AML) is the most common form of acute leukemia in adults. Rapidly proliferating leukemic cells cause symptoms and increase the risk of infection. While individuals may initially benefit from supportive measures, disease-directed the ... Full text Link to item Cite

Palliative and End-of-Life Care in Hematologic Malignancies: Progress and Opportunities.

Journal Article JCO Oncol Pract · June 2024 @JCOOP_ASCO editorial on unique needs of end-of-life care for different blood cancers discusses: #pallheme improves QOL but less utilized in cancers. Contextualize Weisse et al study. More #pallheme research needed for lymphoma and myeloma in era of cell t ... Full text Link to item Cite

A Positive Psychology Intervention in Allogeneic Hematopoietic Stem Cell Transplantation Survivors (PATH): A Pilot Randomized Clinical Trial.

Journal Article J Natl Compr Canc Netw · June 2024 BACKGROUND: Allogeneic hematopoietic stem cell transplantation (HSCT) survivors experience significant psychological distress and low levels of positive psychological well-being, which can undermine patient-reported outcomes (PROs), such as quality of life ... Full text Link to item Cite

A matching-adjusted indirect comparison of the efficacy of elranatamab versus teclistamab in patients with triple-class exposed/refractory multiple myeloma.

Journal Article Leuk Lymphoma · May 2024 For patients with triple-class exposed/refractory multiple myeloma (TCE/RMM), where effective treatments options are limited, B-cell maturation antigen and CD3-directed bispecific antibodies offer a promising new approach. Teclistamab gained conditional ap ... Full text Link to item Cite

Isavuconazonium or posaconazole for antifungal prophylaxis in patients with acute myeloid leukemia.

Journal Article J Oncol Pharm Pract · April 2024 BACKGROUND: Invasive fungal infection (IFI) prophylaxis is recommended in patients with acute myeloid leukemia (AML) during induction chemotherapy. Posaconazole (POSA) is the recommended agent of choice; however, this medication can be associated with QTc ... Full text Link to item Cite

Work absenteeism, disability, and lost wages among patients with acute myeloid leukemia and their caregivers: a cohort study using US administrative claims and productivity data.

Journal Article Expert Rev Pharmacoecon Outcomes Res · April 2024 OBJECTIVE: We describe the impact of acute myeloid leukemia (AML) diagnosis on workplace absenteeism and disability days among patients and their caregivers. METHODS: This retrospective study included adults with newly diagnosed AML (2009-2019) and adult c ... Full text Link to item Cite

Coping in patients with hematologic malignancies undergoing hematopoietic cell transplantation.

Journal Article Blood Adv · March 26, 2024 Patients undergoing hematopoietic cell transplantation (HCT) must cope with physical and psychological symptoms. Yet, studies examining pre-HCT coping are limited. We aimed to characterize pre-HCT coping, evaluate the association of coping with baseline qu ... Full text Link to item Cite

Benefits, Harms, and Stakeholder Perspectives Regarding Opioid Therapy for Pain in Individuals With Metastatic Cancer: Protocol for a Descriptive Cohort Study.

Journal Article JMIR Res Protoc · March 13, 2024 BACKGROUND: Opioids are a key component of pain management among patients with metastatic cancer pain. However, the evidence base available to guide opioid-related decision-making in individuals with advanced cancer is limited. Patients with advanced cance ... Full text Link to item Cite

Protocol for multi-site randomized trial of inpatient palliative care for patients with hematologic malignancies undergoing hematopoietic stem cell transplantation.

Journal Article Contemp Clin Trials · March 2024 BACKGROUND: Patients with hematologic malignancies undergoing hematopoietic stem cell transplantation (HSCT) commonly experience debilitating physical and psychological symptoms during a 3-4-week-hospitalization. During hospitalization, caregivers (i.e., f ... Full text Link to item Cite

Knowledge of Palliative Care and Barriers to Access Among Outpatients with Cancer.

Journal Article J Pain Symptom Manage · February 2024 CONTEXT: Palliative Care (PC) is poorly understood by laypersons. However, little is known about what ambulatory patients with cancer understand about PC or what barriers to access exist. METHODS: Outpatients undergoing cancer treatment completed a survey ... Full text Link to item Cite

A matching-adjusted indirect comparison of the efficacy of elranatamab versus physician's choice of treatment in patients with triple-class exposed/refractory multiple myeloma.

Journal Article Curr Med Res Opin · February 2024 INTRODUCTION: For patients with triple-class exposed/refractory multiple myeloma (TCE/R MM), prognosis is poor and effective treatment options are limited. Elranatamab is a novel B-cell maturation antigen (BCMA)- and CD3-directed bispecific antibody which ... Full text Link to item Cite

Expressive writing to address distress in hospitalized adults with acute myeloid leukemia: a pilot randomized clinical trial.

Journal Article J Psychosoc Oncol · 2024 PURPOSE: Patients with acute myeloid leukemia (AML) experience significant distress. Expressive writing is an intervention designed to improve well-being by encouraging expression of emotions related to traumatic experiences. Expressive writing has been sh ... Full text Link to item Cite

Elranatamab efficacy in MagnetisMM-3 compared with real-world control arms in triple-class refractory multiple myeloma.

Journal Article Future Oncol · 2024 Elranatamab efficacy in the single-arm, registrational MagnetisMM-3 trial (NCT04649359) was compared with that of physician's choice of treatment (PCT) for triple-class refractory multiple myeloma. MagnestisMM-3 eligibility criteria were applied to two USA ... Full text Link to item Cite

Mindful Night-to-Day: A Pilot Feasibility Trial of a Mindfulness-Based Insomnia and Symptom Management Intervention for Patients with Hematologic Cancer.

Journal Article Behav Sleep Med · 2024 OBJECTIVES: Patients with hematologic cancer experience severe symptoms (i.e. insomnia, fatigue, pain, distress). Few interventions addressing insomnia and other symptoms exist for this population. Mindfulness-Based Therapy for Insomnia (MBTI) may be appro ... Full text Link to item Cite

Patient, Care Partner, and Physician Voices in Treatment Decision-Making for Multiple Myeloma.

Journal Article Patient Prefer Adherence · 2024 INTRODUCTION: Treatment decision-making for multiple myeloma (MM) is complex. Individuals involved in decision-making may value treatment attributes differently based on their role as a patient, care partner, or physician. This study describes those attrib ... Full text Link to item Cite

Using machine learning for targeted advance care planning (ACP) conversations in patients with cancer: A quality improvement initiative.

Journal Article Journal of Clinical Oncology · January 1, 2024 Background: Despite improvements, patients with advanced cancer often do not receive goal-concordant care at the end of life (EOL). Challenges with prognostication contribute to delays ACP conversations and result in more aggressive care, gaps in symptom m ... Full text Cite

Palliative Care in Patients With Hematological Malignancies. We Have a Long Way to Go….

Journal Article Am J Hosp Palliat Care · December 2023 Background: Patients with hematological malignancies have significant and diverse palliative care needs but are not usually referred to specialist palliative care services in a timely manner, if at all. Objective: To identify the characteristics of patient ... Full text Link to item Cite

Measuring Social Toxicity in Acute Myeloid Leukemia

Conference Blood · November 2, 2023 Background: AML is an aggressive and costly cancer to treat, which often results in lower quality of life, including worse and more frequent depression and anxiety, physical strains, and financial toxicity. AML can also ... Full text Cite

A Comparison of Acute Myeloid Leukemia (AML) Regimens: Hypomethylating Agents Combined with Ivosidenib or Venetoclax in Newly Diagnosed Patients with IDH1 Mutations: A Real-World Evidence Study

Conference Blood · November 2, 2023 Background: Two frontline combination regimens are available for patients with mutant IDH1 (mIDH1) AML: ivosidenib (IVO)+hypomethylating agent (HMA), and venetoclax (VEN)+HMA. Robust comparisons between these regimens h ... Full text Cite

An Indirect Comparison of Elranatamab's Progression-Free Survival and Overall Survival from Magnetismm-3 Versus Real-World External Control Arms in Triple-Class Refractory Multiple Myeloma

Conference Blood · November 2, 2023 BACKGROUNDElranatamab(ELRA) is a BCMAxCD3 bispecific antibody being investigated for the treatment of relapsed/refractory multiple myeloma (MM). The phase 2 MagnetisMM-3 (MM-3; NCT046493 ... Full text Cite

Coping in Patients with Hematologic Malignancies Undergoing Hematopoietic Cell Transplantation

Conference Blood · November 2, 2023 Background Patients undergoing hematopoietic cell transplantation (HCT) must cope with immense physical and psychological symptoms during HCT hospitalization, which contribute to a dramatic deterioration in quality of l ... Full text Cite

Multiple Myeloma Treatment-Related Decision-Making and Preferences of Patients and Care Partners in the United States

Conference Blood · November 2, 2023 BACKGROUNDMultiple myeloma is a largely incurable disease characterized by periods of response followed by relapse and/or refractoriness to therapy. With many new treatments available, p ... Full text Cite

Comparative Analysis of Clinical Outcomes and Healthcare Resource Utilization (HRU) in Patients (Pts) with Newly Diagnosed (ND) Acute Myeloid Leukemia (AML) Unfit for High-Intensity Chemotherapy Treated with Venetoclax (VEN) Vs Other Therapies: Results from the AML Real World Evidence (ARC) Initiative

Conference Blood · November 2, 2023 Introduction: The BCL-2 inhibitor VEN is approved in combination with hypomethylating agents or low-dose cytarabine for adults with ND AML. The ARC Initiative is a multicenter chart review study of adult pts with AML. T ... Full text Cite

A Matching-Adjusted Indirect Comparison of the Efficacy of Elranatamab Versus Physician's Choice of Treatment in Patients with Triple-Class Exposed/Refractory Multiple Myeloma

Conference Blood · November 2, 2023 BACKGROUNDFor patients with triple-class exposed/refractory multiple myeloma (TCE/R MM), prognosis is poor and limited effective treatment options are available. Elranatamab is a novel B ... Full text Cite

Changing Care Journey for Patients with Multiple Myeloma in the United States

Conference Blood · November 2, 2023 BACKGROUNDManagement of the hematologic malignancy multiple myeloma (MM) requires a sequence of treatment decisions across the course of the disease to extend survival and maximize quali ... Full text Cite

Removing Transfusion Dependence As a Barrier to Hospice Enrollment (BRUOG-407)

Conference Blood · November 2, 2023 Background:Patients with hematologic malignancies (HM) receive more aggressive care at the end of life (EOL) and have suboptimal hospice utilization when compared to patients with solid ... Full text Cite

A Matching-Adjusted Indirect Comparison of the Efficacy of Elranatamab and Teclistamab in Patients with Triple-Class Exposed/Refractory Multiple Myeloma

Conference Blood · November 2, 2023 BACKGROUNDElranatamab, a novel B-cell maturation antigen (BCMA)- and CD3-directed bispecific antibody, recently demonstrated efficacy and safety in patients with triple-class exposed/ref ... Full text Cite

A Positive Psychology Intervention in Allogeneic Hematopoietic Stem Cell Transplantation Survivors (PATH) to Promote Well-Being: Randomized Controlled Feasibility and Preliminary Efficacy Trial

Conference Blood · November 2, 2023 Background: Patients with hematologic malignancies who are allogeneic hematopoietic stem cell transplantation (HSCT) survivors experience tremendous psychological symptoms (e.g., anxiety and depression symptoms) and low ... Full text Cite

Multi-Site Randomized Trial of Inpatient Palliative Care for Hospitalized Patients Undergoing Hematopoietic Stem Cell Transplantation

Conference Blood · November 2, 2023 Background: Patients with hematologic malignancies experience a substantial decline in their quality of life (QOL) and psychological health during their hospitalization for hematopoietic stem cell transplantation (HSCT) ... Full text Cite

Work loss and activity impairment due to extended nausea and vomiting in patients with breast cancer receiving CINV prophylaxis.

Journal Article Support Care Cancer · October 25, 2023 PURPOSE: Chemotherapy-induced nausea and vomiting (CINV)'s impact on work loss remains poorly described. We evaluated associations between the duration of CINV episodes, CINV-related work loss (CINV-WL), and CINV-related activity impairment (CINV-AI) in pa ... Full text Link to item Cite

Innovations for the integration of palliative care for hematologic malignancies.

Journal Article Curr Probl Cancer · October 2023 Specialist palliative care provides additional support to facilitate living well with a serious illness, like cancer, even while pursuing disease-directed therapy. For patients with hematologic malignancies, integrated specialist palliative care improves s ... Full text Link to item Cite

Psychological Distress in Young Adults with Acute Myeloid Leukemia Undergoing Induction Chemotherapy.

Journal Article J Adolesc Young Adult Oncol · August 2023 Young adults (YAs), aged 18-39 years, with acute myeloid leukemia (AML) navigate life disruptions amid an unpredictable illness trajectory. We conducted a secondary analysis of patient-reported outcomes for hospitalized YAs with high-risk AML receiving int ... Full text Link to item Cite

Feasibility of a positive psychology intervention (PATH) in allogeneic hematopoietic stem cell transplantation survivors: Randomized pilot trial design and methods.

Journal Article Contemp Clin Trials · August 2023 BACKGROUND: Although patients undergoing allogeneic hematopoietic stem cell transplantation (HSCT) experience low levels of positive psychological well-being (PPWB), interventions that specifically boost PPWB in this population are lacking. OBJECTIVE: To d ... Full text Link to item Cite

A Mobile App to Support Self-Management in Patients with Multiple Myeloma or Chronic Lymphocytic Leukemia: Pilot Randomized Controlled Trial.

Journal Article JMIR Cancer · July 6, 2023 BACKGROUND: Patients with blood cancer experience serious physical and emotional symptoms throughout their cancer journey. OBJECTIVE: Building on previous work, we aimed to develop an app designed to help patients with multiple myeloma and chronic lymphocy ... Full text Link to item Cite

In their own words: a qualitative study of coping mechanisms employed by patients with acute myeloid leukemia.

Journal Article Support Care Cancer · July 5, 2023 PURPOSE: Positive coping mediates improved outcomes from integrated palliative care in acute myeloid leukemia (AML). We qualitatively explored patients' coping mechanisms to better understand this relationship. METHODS: We enrolled patients with high-risk ... Full text Link to item Cite

Work absenteeism and disability days after diagnosis among patients with AML and caregivers.

Conference Journal of Clinical Oncology · June 1, 2023 e19002 Background: Treatment for acute myeloid leukemia (AML) includes intensive chemotherapy and/or hematopoietic stem cell transplant, and patients usually require extended hospital stays and absence from work. Caregivers may a ... Full text Cite

Quality for all: Clinical trial enrollment and end-of-life care in solid and hematologic malignancies.

Conference Journal of Clinical Oncology · June 1, 2023 12028 Background: All patients with cancer deserve quality end-of-life (EOL) care.Despite established EOL quality metrics, many patients with cancer receive futile, aggressive EOL care with infrequent palliative care involvement ... Full text Cite

An indirect comparison of elranatamab’s (ELRA) objective response rate (ORR) from MagnetisMM-3 (MM-3) vs real-world external control arms in triple-class refractory (TCR) multiple myeloma (MM).

Conference Journal of Clinical Oncology · June 1, 2023 6618 Background: ELRA is a BCMAxCD3 bispecific antibody being investigated for the treatment of R/R MM. The phase 2 MM-3 trial was single-armed; the aim of this study (NCT05565391) was to contextualize the efficacy data from MM-3 ... Full text Cite

What do patients think about palliative care? A national survey of hematopoietic stem cell transplant recipients.

Journal Article Blood Adv · May 23, 2023 Palliative care (PC) benefits patients undergoing hematopoietic stem cell transplantation (HSCT), but it remains underutilized. Although transplant physicians report concerns regarding how patients perceive PC, HSCT recipients' perceptions about PC remain ... Full text Link to item Cite

Advancing Palliative Care Integration in Hematology: Building Upon Existing Evidence.

Journal Article Current treatment options in oncology · May 2023 Opinion statementPatients with hematologic malignancies and their families are among the most distressed of all those with cancer. Despite high palliative care-related needs, the integration of palliative care in hematology is underdeveloped. The ... Full text Cite

Survey of patients and physicians on shared decision-making in treatment selection in relapsed/refractory multiple myeloma.

Journal Article Transl Behav Med · April 15, 2023 Shared decision-making (SDM) is a key component of patient-centered healthcare. SDM is particularly pertinent in the relapsed and/or refractory multiple myeloma (RRMM) setting, in which numerous treatment options can present challenges for identifying opti ... Full text Link to item Cite

Coping in caregivers of patients with hematologic malignancies undergoing hematopoietic stem cell transplantation.

Journal Article Blood Adv · April 11, 2023 Caregivers of patients with hematologic malignancies undergoing hematopoietic stem cell transplantation (HSCT) must cope with substantial caregiving burden, high rates of psychological distress, and diminished quality of life (QOL). However, data describin ... Full text Link to item Cite

Novel agents and regimens in acute myeloid leukemia: latest updates from 2022 ASH Annual Meeting.

Journal Article J Hematol Oncol · March 3, 2023 Developments in investigational agents and novel regimens in acute myeloid leukemia (AML) were reported in the 2022 American Society of Hematology (ASH) annual meeting. Encouraging efficacy data were presented from first-in-human studies of two investigati ... Full text Link to item Cite

Duration of Chemotherapy-Induced Nausea and Vomiting (CINV) as a Predictor of Recurrent CINV in Later Cycles.

Journal Article The oncologist · March 2023 BackgroundThe relationship between CINV duration and recurrence in subsequent cycles is largely unstudied. Our objective was to determine if patients experiencing CINV in their first cycle of chemotherapy (C1) would face increased risk of CINV in ... Full text Cite

A Systematic Review of Decision Aids in Hematologic Malignancies: What Are Currently Available and What Are We Missing?

Journal Article Oncologist · February 8, 2023 BACKGROUND: Patient decision aids (PDAs) are tools designed to facilitate decision-making. In this systematic review, we summarized existing studies on the development and evaluation of PDAs for patients with hematologic malignancies. PATIENTS AND METHODS: ... Full text Link to item Cite

Use of Opioids for Adults With Pain From Cancer or Cancer Treatment: ASCO Guideline.

Journal Article J Clin Oncol · February 1, 2023 PURPOSE: To provide guidance on the use of opioids to manage pain from cancer or cancer treatment in adults. METHODS: A systematic review of the literature identified systematic reviews and randomized controlled trials of the efficacy and safety of opioid ... Full text Link to item Cite

Patient perspectives on considerations, tradeoffs, and experiences with multiple myeloma treatment selection: a qualitative descriptive study.

Journal Article BMC Cancer · January 19, 2023 BACKGROUND: Advances in multiple myeloma treatment and a proliferation of treatment options have resulted in improved survival rates and periods of symptom-free remission for many multiple myeloma patients. As a result, health-related quality of life (HRQo ... Full text Link to item Cite

Advance Care Planning in Serious Illness: A Narrative Review.

Journal Article J Pain Symptom Manage · January 2023 CONTEXT: Advance care planning (ACP) intends to support person-centered medical decision-making by eliciting patient preferences. Research has not identified significant associations between ACP and goal-concordant end-of-life care, leading to justified sc ... Full text Link to item Cite

“More than conquerors”: a qualitative analysis of war metaphors for patients with cancer

Conference Supportive Care in Cancer · January 1, 2023 Purpose: Meaning-making is fundamental to the cancer experience and communication within cancer care is saturated with metaphors. The objective of this study was to better understand the impact and function of war metaphors among patients with cancer. Meth ... Full text Cite

Patient-Reported Distress and Clinical Outcomes with Immuno-Oncology Agents in Metastatic Non-Small Cell Lung Cancer (mNSCLC): A Real-World Retrospective Cohort Study.

Journal Article Lung Cancer · January 2023 OBJECTIVES: There are limited real-world data about patient-reported outcomes with immunotherapies (IO) in metastatic non-small cell lung cancer (mNSCLC). We describe patient-reported distress and clinical outcomes with IO-based treatments or cytotoxic che ... Full text Link to item Cite

An Analysis of Dasatinib Treatment Patterns in Patients with Chronic Myeloid Leukemia after Experiencing Pleural Effusion during Dasatinib Therapy.

Journal Article Acta Haematol · 2023 INTRODUCTION: Treatment with dasatinib for chronic myeloid leukemia (CML) has been associated with development of pleural effusion; however, data regarding its optimal management are limited. We examined treatment patterns and healthcare resource utilizati ... Full text Link to item Cite

The experience of patients with acute myeloid leukemia in remission post-transplant.

Journal Article Leuk Lymphoma · 2023 The symptoms of acute myeloid leukemia (AML) and its treatment can negatively impact patient functioning and quality of life. Through concept elicitation interviews, we sought to evaluate the experience of patients with AML in remission following hematopoi ... Full text Link to item Cite

Did a bot eat your homework? An assessment of the potential impact of bad actors in online administration of preference surveys.

Journal Article PLoS One · 2023 BACKGROUND: Online administration of surveys has a number of advantages but can also lead to increased exposure to bad actors (human and non-human bots) who can try to influence the study results or to benefit financially from the survey. We analyze data c ... Full text Link to item Cite

"More than conquerors": a qualitative analysis of war metaphors for patients with cancer.

Journal Article Support Care Cancer · December 27, 2022 PURPOSE: Meaning-making is fundamental to the cancer experience and communication within cancer care is saturated with metaphors. The objective of this study was to better understand the impact and function of war metaphors among patients with cancer. METH ... Full text Link to item Cite

Indirect treatment comparison of oral versus injectable azacitidine as maintenance therapy for acute myeloid leukemia.

Journal Article Future Oncol · December 12, 2022 Aim: Evaluate the relative efficacy of oral versus injectable azacitidine (AZA) maintenance therapy in acute myeloid leukemia (AML) after complete remission. Materials & methods: Systematic literature review identified QUAZAR AML-001, HOVON 97 AML, UK NCRI ... Full text Link to item Cite

Patient, Family Member and Physician Perspectives and Experiences with AML Treatment Decision-Making.

Journal Article Oncol Ther · December 2022 INTRODUCTION: Treatment decisions in older adults with acute myeloid leukemia (AML) are challenging, particularly for those who are not candidates for intensive chemotherapy (IC), and the trade-offs patients, their families and physicians consider when cho ... Full text Link to item Cite

Integrative Medicine for Pain Management in Oncology: Society for Integrative Oncology-ASCO Guideline.

Journal Article J Clin Oncol · December 1, 2022 PURPOSE: The aim of this joint guideline is to provide evidence-based recommendations to practicing physicians and other health care providers on integrative approaches to managing pain in patients with cancer. METHODS: The Society for Integrative Oncology ... Full text Link to item Cite

A single-site pilot feasibility randomized trial of a supportive care mobile application intervention for patients with advanced cancer and caregivers.

Journal Article Support Care Cancer · October 2022 PURPOSE: Mobile health interventions can improve patient care. We developed the Digital Supportive Care Awareness and Navigation (D-SCAN) application (app) to facilitate symptom monitoring and use/awareness of cancer supportive care resources. This study t ... Full text Link to item Cite

Relationship Between Longitudinal Coping Strategies and Outcomes in Patients With Acute Myeloid Leukemia.

Journal Article J Natl Compr Canc Netw · October 2022 BACKGROUND: Patients with acute myeloid leukemia (AML) face an abrupt life-threatening illness and experience immense physical and psychological symptoms. However, no data describe how patients with AML cope longitudinally with their illness or the relatio ... Full text Link to item Cite

Economic burden in US patients with newly diagnosed acute myeloid leukemia receiving intensive induction chemotherapy.

Journal Article Future Oncol · October 2022 Aim: This retrospective, observational study assessed healthcare resource utilization (HCRU) and costs for newly diagnosed acute myeloid leukemia (AML) patients receiving intensive induction chemotherapy. Materials & methods: Adult AML patients with inpati ... Full text Link to item Cite

Utilization of Text Messages to Supplement Rounding Communication: a Randomized Feasibility Study.

Journal Article J Gen Intern Med · September 2022 BACKGROUND: Fragmented communication with patients and families during hospitalizations often leaves patients confused about the daily plan. OBJECTIVE: To pilot a supplemental text message-based platform for improving bidirectional communication about the ... Full text Open Access Link to item Cite

Clinicians' Understanding of Preferences and Values of People with Hematological Malignancies at the End of Life: Concurrent Surveys.

Journal Article J Palliat Med · September 2022 Background: People with hematological malignancies can deteriorate rapidly to a terminal event and have variable levels of engagement when transitioning to palliative and end-of-life care. Objectives: To describe end-of-life care values and preferences of ... Full text Link to item Cite

Costs per patient achieving remission with venetoclax-based combinations in newly diagnosed patients with acute myeloid leukemia ineligible for intensive induction chemotherapy.

Journal Article J Manag Care Spec Pharm · September 2022 BACKGROUND: Venetoclax, in combination with azacitidine, decitabine, or low-dose cytarabine (LDAC), received confirmatory approval in 2020 by the US Food and Drug Administration for the treatment of newly diagnosed acute myeloid leukemia (AML) in patients ... Full text Link to item Cite

Palliative care for patients with hematologic malignancies: are we meeting patients' needs early enough?

Journal Article Expert Rev Hematol · September 2022 INTRODUCTION: Palliative care for patients with cancer, and more recently for patients with hematologic malignancies, has increasingly been shown to be beneficial, with mounting evidence pointing to its vast benefits both to patients and caregivers. Despit ... Full text Link to item Cite

Code status transitions in patients with high-risk acute myeloid leukemia.

Journal Article Blood Adv · July 26, 2022 Patients with high-risk acute myeloid leukemia (AML) often experience intensive medical care at the end of life (EOL), including high rates of hospitalizations and intensive care unit (ICU) admissions. Despite this, studies examining code status transition ... Full text Link to item Cite

The association between changes in symptoms or quality of life and overall survival in outpatients with advanced cancer.

Journal Article Ann Palliat Med · July 2022 BACKGROUND: Several prognostic tools have been developed to aid clinicians in survival prediction. However, changes in symptoms are rarely included in established prognostic systems. We aimed to investigate the influence of changes in symptoms and quality ... Full text Link to item Cite

A cross-sectional observational study of health-related quality of life in adults with multiple myeloma.

Journal Article Support Care Cancer · June 2022 BACKGROUND: The purpose of this manuscript is to describe health-related quality of life (HRQoL) outcomes in a United States (US)-based sample of multiple myeloma (MM) patients and identify characteristics associated with poor HRQoL. PATIENTS AND METHODS: ... Full text Link to item Cite

Factors Associated with Health Care Utilization at the End of Life for Patients with Acute Myeloid Leukemia.

Journal Article J Palliat Med · May 2022 Background: Patients (≥60 years) with acute myeloid leukemia (AML) often receive intense health care utilization at the end of life (EOL). However, factors associated with their health care use at the EOL are unknown. Methods: We conducted a secondary anal ... Full text Link to item Cite

Coping strategies in patients with acute myeloid leukemia.

Journal Article Blood Adv · April 12, 2022 Patients diagnosed with acute myeloid leukemia (AML) face sudden-onset life-threatening disease that requires intensive treatments. Although their early disease trajectory is characterized by significant, toxic side effects, limited data are available desc ... Full text Link to item Cite

Impact of Early Palliative Care on End-of-Life Outcomes in Hematologic Malignancies.

Conference J Palliat Med · April 2022 Background: Patients with hematologic malignancies (HMs) receive more disease directed care at the end of life (EOL) and often die in the hospital. The impact of early palliative care (PC) consultation on EOL quality outcomes in HMs has not been well descr ... Full text Link to item Cite

Triadic agreement about advanced cancer treatment decisions: Perceptions among patients, families, and oncologists.

Journal Article Patient Educ Couns · April 2022 OBJECTIVES: When patients make cancer treatment decisions, they consider the needs and preferences of family caregivers and clinicians. We examined how much all three triad members agreed about goals of treatment and caregivers' influence on decision-makin ... Full text Link to item Cite

Patient-reported distress as an early warning sign of unmet palliative care needs and increased healthcare utilization in patients with advanced cancer.

Journal Article Support Care Cancer · April 2022 INTRODUCTION: Cancer patients' sources of distress are often unaddressed, and patient-reported distress data could be utilized to identify those with unmet and impending care needs. We explored the association between moderate/severe distress and healthcar ... Full text Link to item Cite

Bridging New Technology Into Clinical Practice With Mobile Apps, Electronic Patient-Reported Outcomes, and Wearables.

Journal Article Am Soc Clin Oncol Educ Book · April 2022 With sophisticated mobile and wearable technologies available, there has been interest in leveraging these devices to help gather and analyze patient-generated health data (PGHD). This information could be used to better address health concerns, aid in tre ... Full text Link to item Cite

Assessment of Changes in Symptoms Is Feasible and Prognostic in the Last Weeks of Life: An International Multicenter Cohort Study.

Journal Article J Palliat Med · March 2022 Background: Symptoms are not typically part of established various prognostic factors and scoring systems but are among the most frequently assessed issues in patient care. Objectives: To evaluate that, changes in symptoms can provide additional useful pro ... Full text Link to item Cite

Reply to Paul and Lewis.

Journal Article Pain · March 1, 2022 Full text Link to item Cite

Persistent fatigue among long-term non-Hodgkin lymphoma survivors.

Journal Article Leuk Lymphoma · February 2022 This study describes the prevalence and persistence of fatigue among a cohort of long-term non-Hodgkin lymphoma (NHL) survivors. Mailed surveys assessed quality-of-life including fatigue (SF-36) at baseline and five years. Logistic regression was used to i ... Full text Link to item Cite

Do you mind if I record?: Perceptions and practice regarding patient requests to record clinic visits in oncology.

Journal Article Cancer · January 15, 2022 BACKGROUND: Audio recordings of oncology clinic discussions can help patients retain and understand information about their disease and treatment decisions. Access to this tool relies on acceptance of recordings by oncologists. This is the first study to e ... Full text Link to item Cite

Lean Into the Uncomfortable: Using Trauma-Informed Care to Engage in Shared Decision-Making With Racial Minorities With Hematologic Malignancies.

Journal Article Am J Hosp Palliat Care · January 2022 Discussions involving racial health disparities must include pathways for engaging in shared decision-making with racial/ethnic minorities. Research demonstrates glaring racial and ethnic disparities when it comes to hematologic malignancies from the time ... Full text Link to item Cite

The relationship between emotional well-being and understanding of prognosis in patients with acute myeloid leukemia (AML).

Journal Article Support Care Cancer · January 2022 PURPOSE: Adults with acute myeloid leukemia (AML) face considerable distress and often have a poor prognosis. However, little is known about these patients' perceptions of prognosis and how this relates to emotional well-being (EWB). METHODS: We conducted ... Full text Link to item Cite

Venous Thromboembolism in Patients with Cancer Receiving Specialist Palliative Care.

Journal Article Clin Appl Thromb Hemost · 2022 CONTEXT: The prevalence of venous thromboembolism (VTE) in patients with cancer is particularly high at disease progression and during relapse. Patients cared for in specialized palliative care units (SPCU) are rarely included in VTE studies. Objective: We ... Full text Link to item Cite

The impact of remission duration on the long-term economic burden of acute myeloid leukemia among patients without hematopoietic stem cell transplant in the United States.

Journal Article J Med Econ · 2022 BACKGROUND AND AIMS: Acute myeloid leukemia (AML) prognosis is poor, with sustained remission occurring in <35% of young adults and <15% of older adults. This descriptive study examined the potential benefit of prolonged remission on the economic burden of ... Full text Link to item Cite

Pain Management and Antiemetic Therapy in Hematologic Disorders

Chapter · January 1, 2022 Relieving pain in patients with hematologic disorders requires a multifaceted approach. This chapter provides the clinician with the tools to perform a systematic evaluation of the pain complaint and propose a rational, evidence-based, strategy. After the ... Full text Cite

Palliative care and coping in patients with acute myeloid leukemia: Mediation analysis of data from a randomized clinical trial.

Conference Cancer · December 15, 2021 BACKGROUND: It has been shown previously that integrated palliative care for patients with acute myeloid leukemia (AML) during intensive chemotherapy leads to improvements in quality of life (QOL) and mood. Coping has been shown to mediate palliative care ... Full text Link to item Cite

Distress in a Pandemic: Association of the Coronavirus Disease-2019 Pandemic with Distress and Quality of Life in Hematopoietic Stem Cell Transplantation.

Journal Article Transplant Cell Ther · December 2021 The global coronavirus disease 2019 (COVID-19) pandemic has drastically disrupted cancer care, potentially exacerbating patients' distress levels. Patients undergoing hematopoietic stem cell transplantation (HSCT) may be especially vulnerable to this pande ... Full text Link to item Cite

A matter of time: how does emotion influence temporal aspects of remembering?

Journal Article Cogn Emot · December 2021 Spatiotemporal context is an intrinsic aspect of episodic memory. Although a large literature has demonstrated that emotion enhances episodic memory, less research has considered whether and how emotion affects memory for the timing of an experience, despi ... Full text Link to item Cite

The Associations between Coping Strategy Use and Patient-Reported Outcomes in Patients with Acute Myeloid Leukemia

Conference Blood · November 5, 2021 AbstractBackground: Patients with acute myeloid leukemia (AML) who receive intensive chemotherapy must cope with immense physical and psychological symptoms associated with a variety of patient-reported outc ... Full text Cite

The Relationship between Depression, Anxiety, and Clinical Trial Perceptions Among Patients with Hematologic Cancer

Conference Blood · November 5, 2021 AbstractIntroduction. Despite the fact that thousands of cancer clinical trials (CCTs) are available today, engagement remains low, with only 2-7% of patients with cancer participating in CCTs. Research has ... Full text Cite

Healthcare Resource Utilization and Costs in US Patients with Newly Diagnosed Acute Myeloid Leukemia Treated with Intensive Induction Chemotherapy

Conference Blood · November 5, 2021 AbstractINTRODUCTION:Acute myeloid leukemia (AML) is a heterogeneous hematologic malignancy. In the United States (US) in 2020, the incidence of AML was 4.3/100,000, with a d ... Full text Cite

Code Status Transitions in Patients with High-Risk Acute Myeloid Leukemia (AML)

Conference Blood · November 5, 2021 AbstractBackground:Patients with high-risk AML often experience intensive medical care at the end of life (EOL) such as hospitalization and intensive care unit (ICU) admissio ... Full text Cite

Dasatinib Treatment Patterns after Pleural Effusion Among Patients with Chronic Myeloid Leukemia

Conference Blood · November 5, 2021 AbstractIntroductionDecision-making in the treatment (Tx) of chronic myeloid leukemia (CML) is complex and dependent on many factors, including disease phase and drug tolerab ... Full text Cite

What Do Patients Think about Palliative Care? a National Survey of Hematopoietic Stem Cell Transplant Recipients

Conference Blood · November 5, 2021 AbstractBackground: Palliative care (PC) benefits patients with cancer and those undergoing hematopoietic stem cell transplantation (HSCT), but remains under-utilized in HSCT. While transplant physicians hav ... Full text Cite

Acute Myeloid Leukemia in Western Kenya: A Snapshot

Conference Blood · November 5, 2021 AbstractIntroduction: Steady advances in the treatment of acute myeloid leukemia (AML) have improved outcomes in high-resource settings, with a 5-year overall survival rate of 29% and rising in the United St ... Full text Cite

Symptoms and Impacts Reported By Patients with Acute Myeloid Leukemia (AML) in Remission Post-Stem Cell Transplant

Conference Blood · November 5, 2021 AbstractBackgroundLittle is known about the burden of symptoms and impacts on quality of life in patients with AML in the posttransplant period. As treatment options for AML ... Full text Cite

Perceptions of Hematology Among Palliative Care Physicians: Results of a Nationwide Survey.

Journal Article J Pain Symptom Manage · November 2021 CONTEXT: Palliative care integration for patients with hematologic diseases has lagged behind solid-organ malignancies. Previous work has characterized hematologist perspectives, but less is known about palliative care physician views of this phenomenon. O ... Full text Link to item Cite

Targeting health-related quality of life in patients with myelodysplastic syndromes - Current knowledge and lessons to be learned.

Journal Article Blood Rev · November 2021 Using a range of health-related quality of life (HRQoL) instruments, most - but not all - studies of myelodysplastic syndromes (MDS) have reported that lower hemoglobin levels and red blood cell transfusion dependency are associated with worse HRQoL. In ad ... Full text Link to item Cite

The patient experience of ABVD treatment in Hodgkin lymphoma: a retrospective cohort study of patient-reported distress.

Journal Article Support Care Cancer · September 2021 PURPOSE: Psychological distress is prevalent in Hodgkin lymphoma (HL). Many patients, regardless of prognosis, receive ABVD chemotherapy as first-line treatment, but few studies have specifically examined the nature of distress during this shared treatment ... Full text Link to item Cite

Parental limited English proficiency in pediatric stem cell transplantation: Clinical impact and health care utilization.

Journal Article Pediatr Blood Cancer · September 2021 BACKGROUND: Limited English proficiency (LEP) is associated with adverse clinical outcomes. The clinical impact of LEP in hematopoietic stem cell transplant (HSCT) has not been studied. The objectives of this study were to compare HSCT outcomes and health ... Full text Link to item Cite

Posttraumatic stress disorder symptoms in patients with acute myeloid leukemia.

Journal Article Cancer · July 15, 2021 BACKGROUND: Patients with acute myeloid leukemia (AML) receiving intensive chemotherapy face a life-threatening illness, isolating hospitalization, and substantial physical and psychological symptoms. However, data are limited regarding risk factors of pos ... Full text Link to item Cite

A novel decision aid for acute myeloid leukemia: a feasibility and preliminary efficacy trial.

Journal Article Support Care Cancer · July 2021 PURPOSE: Acute myeloid leukemia (AML) is a hematologic malignancy characterized by a poor prognosis but also a paradoxical possibility of cure. This renders decision-making complex and imminent. Unfortunately, many patients with AML misestimate their progn ... Full text Link to item Cite

Burden of illness and treatment patterns among patients with peripheral T-cell lymphoma in the US healthcare setting.

Journal Article Curr Med Res Opin · July 2021 OBJECTIVE: Limited real-world information exists on the characteristics or treatment patterns of patients with peripheral T-cell lymphoma (PTCL). We reported demographics, treatments and direct healthcare resource utilization (HRU) in a large cohort of US ... Full text Link to item Cite

Revisiting patient-related barriers to cancer pain management in the context of the US opioid crisis.

Journal Article Pain · June 1, 2021 Patient fear of addiction is a well-documented barrier to the use of analgesic medications for cancer pain control. Over the past 2 decades in the United States, an "opioid crisis" has arisen, accompanied by risk messages delivered through news outlets, pu ... Full text Link to item Cite

Associations of coping strategies with quality of life (QOL) and mood in patients with acute myeloid leukemia (AML).

Conference Journal of Clinical Oncology · May 20, 2021 e19012 Background: Patients with AML who receive intensive chemotherapy experience immense physical and psychological symptoms, which can result in a substantial deterioration of QOL. As data on the relationship between AML patie ... Full text Cite

Patient concerns and disruptions in cancer care during the COVID-19 pandemic.

Conference Journal of Clinical Oncology · May 20, 2021 e18716 Background: The COVID-19 pandemic has uniquely impacted the lives of people with cancer, but the specifics of these impacts are not fully understood. We examined: 1) the impact of COVID-19 on cancer-related health care, an ... Full text Cite

Code status transitions in patients with high-risk acute myeloid leukemia (AML).

Conference Journal of Clinical Oncology · May 20, 2021 e19009 Background: Patients with high-risk AML often experience aggressive medical care at the end of life (EOL) such as hospitalization and intensive care unit (ICU) admission. Despite this, studies examining code status transit ... Full text Cite

A mixed methods study exploring the role of perceived side effects on treatment decision-making in older adults with acute myeloid leukemia (AML).

Conference Journal of Clinical Oncology · May 20, 2021 7016 Background: AML patients may be treated with intensive chemotherapy (IC), or non-intensive chemotherapy (NIC) or they may receive best supportive care (BSC) or hospice care. Balancing treatment efficacy and toxicities is key ... Full text Cite

Distress in a pandemic: The association of the coronavirus disease-2019 (COVID-19) pandemic with distress and quality of life in hematopoietic stem cell transplantation (HSCT).

Conference Journal of Clinical Oncology · May 20, 2021 7032 Background: The global COVID-19 pandemic has drastically disrupted cancer care, potentially exacerbating patients’ distress levels. Patients with hematologic malignancies undergoing HSCT may be especially vulnerable to this ... Full text Cite

Palliative care and coping in patients with acute myeloid leukemia receiving intensive induction therapy: A mediation analysis of data from a randomized trial.

Conference Journal of Clinical Oncology · May 20, 2021 12007 Background: Patients with acute myeloid leukemia (AML) receiving intensive induction chemotherapy experience significant symptoms, quality of life impairment, anxiety, and depression. We previously showed that integrated pa ... Full text Cite

Caregiver-guided pain coping skills training for patients with advanced cancer: Results from a randomized clinical trial.

Journal Article Palliat Med · May 2021 BACKGROUND: Pain is a major concern among patients with advanced cancer and their family caregivers. Evidence suggests that pain coping skills training interventions can improve outcomes, however they have rarely been tested in this population. AIM: To tes ... Full text Link to item Cite

Avoidable Acute Care Use Associated with Nausea and Vomiting Among Patients Receiving Highly Emetogenic Chemotherapy or Oxaliplatin.

Journal Article Oncologist · April 2021 PURPOSE: Chemotherapy-induced nausea and vomiting (CINV) contributes to avoidable acute care, a metric now tracked in Medicare's oncology outcome measure. CINV is preventable, yet guidelines are often not followed. We sought to quantify acute care involvin ... Full text Link to item Cite

A Qualitative Study of the Experiences of Living With Multiple Myeloma.

Journal Article Oncol Nurs Forum · March 1, 2021 PURPOSE: To explore the ways in which multiple myeloma affects an individual's life in the modern treatment era. PARTICIPANTS & SETTING: 15 individuals with multiple myeloma and 10 clinicians were recruited from two academic medical centers in the sout ... Full text Link to item Cite

Effectiveness of Integrated Palliative and Oncology Care for Patients With Acute Myeloid Leukemia: A Randomized Clinical Trial.

Journal Article JAMA Oncol · February 1, 2021 IMPORTANCE: Patients with acute myeloid leukemia (AML) receiving intensive chemotherapy experience substantial decline in their quality of life (QOL) and mood during their hospitalization for induction chemotherapy and often receive aggressive care at the ... Full text Link to item Cite

Early Palliative Care Services and End-of-Life Care in Medicare Beneficiaries with Hematologic Malignancies: A Population-Based Retrospective Cohort Study.

Journal Article J Palliat Med · January 2021 Background: Patients with hematologic malignancies (HM) often receive aggressive care at the end of life (EOL). Early palliative care (PC) has been shown to improve EOL care outcomes, but its benefits are less established in HM than in solid tumors. Object ... Full text Link to item Cite

Health Care Resource Utilization and Costs Among Medicare Beneficiaries Newly Diagnosed With Peripheral T-cell Lymphoma: A Retrospective Claims Analysis.

Journal Article Clin Lymphoma Myeloma Leuk · January 2021 BACKGROUND: There are limited data on the treatment patterns, health care resource utilization (HRU), survival outcomes, and medical costs among Medicare beneficiaries newly diagnosed with peripheral T-cell lymphoma (PTCL). PATIENTS AND METHODS: This was a ... Full text Link to item Cite

Oncologist and Patient Preferences for Novel Agents in First-Line Treatment for Chronic Lymphocytic Leukemia: Commonalities and Disconnects.

Journal Article Patient Prefer Adherence · 2021 PURPOSE: Treatment for chronic lymphocytic leukemia (CLL) has changed dramatically with the approval of novel agents. Information regarding how patients and oncologists make trade-offs across attributes of novel therapies is limited. The purpose of this st ... Full text Link to item Cite

Intensive versus less-intensive antileukemic therapy in older adults with acute myeloid leukemia: A systematic review.

Journal Article PLoS One · 2021 To compare the effectiveness and safety of intensive antileukemic therapy to less-intensive therapy in older adults with acute myeloid leukemia (AML) and intermediate or adverse cytogenetics, we searched the literature in Medline, Embase, and CENTRAL to id ... Full text Link to item Cite

Systematic review of decision aids in hematologic malignancies

Conference JOURNAL OF THE AMERICAN GERIATRICS SOCIETY · 2021 Cite

Health-related quality of life in adults with multiple myeloma

Conference QUALITY OF LIFE RESEARCH · 2021 Cite

Decisional involvement and information preferences of patients with hematologic malignancies.

Journal Article Blood Adv · November 10, 2020 Understanding decisional involvement and information preferences in patients with hematologic malignancies may help to optimize physician-patient communication about treatment decisions and align the decision-making processes with patients' preferences. We ... Full text Link to item Cite

Treatment Decision-Making and Decisional Support Experiences Among Acute Myeloid Leukemia Survivors

Conference Blood · November 5, 2020 Background: With the availability of newer acute myeloid leukemia (AML) treatment combinations and targeted therapies, it is important for patients to understand all available treatment options, including their associated benefits, risks and side e ... Full text Cite

Decisional Involvement, Information Preferences, and Prognostic Optimism Among Patients with Hematologic Malignancies

Conference Blood · November 5, 2020 Introduction:Understanding decisional involvement and information preferences in patients with hematologic malignancies may help to optimize physician-patient communication about treatment decisions and align the de ... Full text Cite

Financial Burden Is Associated with Postponing Care and Decreasing Physical and Emotional Quality of Life Among Patients with Multiple Myeloma and Chronic Lymphocytic Leukemia

Conference Blood · November 5, 2020 Background: Numerous factors contribute to the financial burden experienced by the cancer population, including medical expenses and possible job disruption or loss. The financial burdens that accompany a cancer diagnosis can influence cancer-care ... Full text Cite

Patient Experiences with Liposomal Daunorubicin and Cytarabine (CPX-351) Versus Conventional Induction Regimens: An Analysis of Patient-Reported Outcomes Data from a Prospective Trial

Conference Blood · November 5, 2020 Background: CPX-351 (Vyxeos®; daunorubicin and cytarabine liposome for injection) is a treatment for adults with newly diagnosed AML with myelodysplasia-related changes or therapy-related AML. Intensive induction chemotherapy causes marked symptom ... Full text Cite

Morphologic Leukemia-Free State in Acute Myeloid Leukemia Is Sufficient for Successful Allogeneic Hematopoietic Stem Cell Transplant

Conference Blood · November 5, 2020 Allogeneic hematopoietic cell transplant (HCT) improves survival in patients with relapsed or high risk acute myeloid leukemia (AML). Complete remission (CR) is typically a pre-requisite for transplantation, though many do not achieve a formal CR. ... Full text Cite

Post-Traumatic Stress Disorder (PTSD) Symptoms in Patients with Acute Myeloid Leukemia (AML)

Conference Blood · November 5, 2020 Background: Patients with acute myeloid leukemia (AML) receiving intensive chemotherapy face a life-threatening illness, experience a prolonged, isolating hospitalization, and endure substantial physical and psychological symptoms. Some patients wi ... Full text Cite

Annual Healthcare Resource Utilization and Costs in US Patients Diagnosed with Relapsed Acute Myeloid Leukemia

Conference Blood · November 5, 2020 Introduction: Acute myeloid leukemia (AML) is a malignant form of bone marrow cancer commonly diagnosed in older adults. The age-adjusted incidence of AML in the USA is 4.3 per 100,000, with a median age of 68 years at diagnosis. Once diagnosed, tr ... Full text Cite

Multi-Site Randomized Trial of Integrated Palliative and Oncology Care for Patients with Acute Myeloid Leukemia (AML)

Conference Blood · November 5, 2020 Background: Patients with AML receiving intensive chemotherapy experience substantial decline in their quality of life (QOL) and mood during their hospitalization for induction chemotherapy and often receive aggressive care at the end of life (EOL) ... Full text Cite

How Do Progression-Free Survival and Toxicity Risks Influence Oncologist and Patient Preferences for Novel Agents in Chronic Lymphocytic Leukemia?

Conference Blood · November 5, 2020 Introduction: Treatment for chronic lymphocytic leukemia (CLL) has changed with the approval of novel agents, which have different toxicity profiles. The aim of the current analysis was to determine how incremental changes in efficacy and toxicity ... Full text Cite

Factors Associated with High Healthcare Utilization at the End-of-Life (EOL) for Patients with Acute Myeloid Leukemia

Conference Blood · November 5, 2020 INTRODUCTION: High rates of healthcare utilization at the EOL have been shown to negatively impact patients' quality-of-life (QOL), psychological distress, and caregivers' bereavement outcomes. Older patients (&gt; 60 years) with acute myeloid ... Full text Cite

Indirect Treatment Comparison of CC-486 Versus Azacitidine (AZA) As Maintenance Therapy for Acute Myeloid Leukemia (AML)

Conference Blood · November 5, 2020 Introduction: For medically fit patients with AML, intensive chemotherapy (IC) is used to induce complete remission (CR). Following CR, some patients may be considered for curative-intent hematopoietic stem cell transplantation. For others, the aim ... Full text Cite

Comparison of End-of-Life Care Quality Outcomes and Indicators of Palliative Needs between Medicare Beneficiaries with Solid and Hematologic Malignancies

Conference Blood · November 5, 2020 Background: Patients (pts) with hematologic malignancies (HM) are thought to have suboptimal hospice utilization and receive more aggressive end of life (EOL) care than those with solid tumors (ST), including high rates of EOL chemotherapy use, ICU ... Full text Cite

An analysis of missing items in real-world electronic patient reported outcomes data: implications for clinical care.

Journal Article Support Care Cancer · November 2020 PURPOSE: Utilization of electronic patient-reported outcomes (ePROs) in the clinic can improve quality of life and prolong survival in cancer care. However, there remain unanswered questions regarding trends in missing data and the potential effect on real ... Full text Link to item Cite

Oral adherence in adults with acute myeloid leukemia (AML): results of a mixed methods study.

Journal Article Support Care Cancer · November 2020 INTRODUCTION: The incidence of AML is increasing, in part due to an aging population. Since 2017, eight novel agents have been introduced, 6 of which are oral: midostaurin, enasidenib, ivosidenib, gilteritinib, glasdegib, and venetoclax. With an increase i ... Full text Link to item Cite

Implementation of Electronic Patient-Reported Outcomes in Routine Cancer Care at an Academic Center: Identifying Opportunities and Challenges.

Journal Article JCO Oncol Pract · November 2020 PURPOSE: Electronic patient-reported outcomes (ePROs) can help clinicians proactively assess and manage their patients' symptoms. Despite known benefits, there is limited adoption of ePROs into routine clinical care as a result of workflow and technologic ... Full text Link to item Cite

Primary Palliative Care for Patients with Advanced Hematologic Malignancies: A Pilot Trial of the SHARE Intervention.

Journal Article J Palliat Med · October 19, 2020 Objective: Develop and pilot-test a nurse-led primary palliative care intervention for patients with advanced hematologic malignancies. Background: Nurse-led primary palliative care interventions may improve outpatient palliative care provision for patient ... Full text Link to item Cite

Reply to J. Schildmann et al.

Journal Article J Clin Oncol · August 20, 2020 Full text Link to item Cite

American Society of Hematology 2020 guidelines for treating newly diagnosed acute myeloid leukemia in older adults.

Journal Article Blood Adv · August 11, 2020 BACKGROUND: Older adults with acute myeloid leukemia (AML) represent a vulnerable population in whom disease-based and clinical risk factors, patient goals, prognosis, and practitioner- and patient-perceived treatment risks and benefits influence treatment ... Full text Link to item Cite

End-of-life care quality outcomes among Medicare beneficiaries with hematologic malignancies.

Journal Article Blood Adv · August 11, 2020 Patients with hematologic malignancies are thought to receive more aggressive end-of-life (EOL) care and have suboptimal hospice use compared with patients with solid tumors, but descriptions of EOL outcomes from comprehensive cohorts have been lacking. We ... Full text Link to item Cite

Symptom Burden, Perceived Control, and Quality of Life Among Patients Living With Multiple Myeloma.

Journal Article J Natl Compr Canc Netw · August 2020 BACKGROUND: New therapies for multiple myeloma (MM) have improved survival rates but often expose patients to heightened toxicities and prolonged treatment, leading to increasing complications and side effects. We evaluated the association between symptom ... Full text Link to item Cite

How are patient-reported outcomes and symptoms being measured in adults with relapsed/refractory multiple myeloma? A systematic review.

Journal Article Qual Life Res · June 2020 PURPOSE: Patients with relapsed and/or refractory multiple myeloma (RRMM) are living longer due in part to changing treatment patterns. It is important to understand how changing treatment patterns affect patients' lives beyond extending survival. Research ... Full text Link to item Cite

Microtransplantation in older patients with AML: A pilot study of safety, efficacy and immunologic effects.

Journal Article Am J Hematol · June 2020 Older AML patients have low remission rates and poor survival outcomes with standard chemotherapy. Microtransplantation (MST) refers to infusion of allogeneic hematopoietic stem cells without substantial engraftment. MST has been shown to improve clinical ... Full text Link to item Cite

What the HEC? Clinician Adherence to Evidence-Based Antiemetic Prophylaxis for Highly Emetogenic Chemotherapy.

Journal Article J Natl Compr Canc Netw · June 2020 BACKGROUND: Clinician adherence to antiemetic guidelines for preventing chemotherapy-induced nausea and vomiting (CINV) caused by highly emetogenic chemotherapy (HEC) remains poorly characterized. The primary aim of this study was to evaluate individual cl ... Full text Link to item Cite

When to Integrate Palliative Care in the Trajectory of Cancer Care.

Journal Article Curr Treat Options Oncol · April 23, 2020 Palliative care provides an extra layer of support to patients and families facing a serious illness. To date, several studies support the use of early, integrated palliative care for patients with cancer, based upon documented improvements in quality of l ... Full text Link to item Cite

Palliative and End-of-Life Care for Patients With Hematologic Malignancies.

Journal Article J Clin Oncol · March 20, 2020 Hematologic malignancies are a heterogeneous group of diseases with unique illness trajectories, treatment paradigms, and potential for curability, which affect patients' palliative and end-of-life care needs. Patients with hematologic malignancies endure ... Full text Link to item Cite

Patient-hematologist discordance in perceived chance of cure in hematologic malignancies: A multicenter study.

Journal Article Cancer · March 15, 2020 BACKGROUND: Ensuring that patients with hematologic malignancies have an accurate understanding of their likelihood of cure is important for informed decision making. In a multicenter, longitudinal study, the authors examined discordance in patients' perce ... Full text Link to item Cite

Palliative care in hematologic malignancies: a multidisciplinary approach.

Journal Article Expert Rev Hematol · March 2020 Introduction: Palliative care is specialized health care focused on improving the quality of life amid serious illness. Patients with hematologic malignancies have significant needs that could be addressed by a multidisciplinary palliative care team, but t ... Full text Link to item Cite

Abstract P5-14-07: Avoidable acute care involving chemotherapy-induced nausea and vomiting (CINV) among patients with breast cancer receiving anthracycline + cyclophosphamide (AC) with NEPA prophylaxis relative to other antiemetics: An external control arm analysis

Conference Cancer Research · February 15, 2020 AbstractBackground: Anthracycline and cyclophosphamide (AC) is a highly emetogenic chemotherapy (HEC) regimen. Combination netupitant/palonosetron (NEPA) + dexamethasone (DEX) is guideline-recommended for pr ... Full text Cite

End-of-Life Care, Palliative Care Consultation, and Palliative Care Referral in the Emergency Department: A Systematic Review.

Journal Article J Pain Symptom Manage · February 2020 CONTEXT: There is growing interest in providing palliative care (PC) in the emergency department (ED), but relatively little is known about the efficacy of ED-based PC interventions. A 2016 systematic review on this topic found no evidence that ED-based PC ... Full text Link to item Cite

Impact of Addition of Carboplatin AUC ≥ 4 to Antiemetic Guidelines for Triple Antiemetic Prophylaxis: A Gap in Quality of Care, Guideline Adoption, and Avoiding Acute Care.

Journal Article JCO Oncol Pract · February 2020 PURPOSE: After ASCO and National Comprehensive Cancer Network guideline recommendations for triple antiemetic prophylaxis for carboplatin area under the curve (AUC) ≥ 4, and the publication of studies documenting avoidable acute care after chemotherapy inv ... Full text Link to item Cite

Unintentional weight loss, its associated burden, and perceived weight status in people with cancer.

Journal Article Support Care Cancer · January 2020 PURPOSE: Unintentional weight loss (UWL) is a prevalent problem in people with cancer and is associated with poorer psychosocial outcomes. A gap exists in understanding whether and how perceived and/or weight status impacts experiences of UWL. Thus, we sou ... Full text Link to item Cite

Fatigue trajectories in long-term non-Hodgkin lymphoma survivors.

Conference JOURNAL OF CLINICAL ONCOLOGY · 2020 Cite

Introduction

Chapter · December 1, 2019 Full text Cite

Opportunities to Improve Utilization of Palliative Care Among Adults With Cystic Fibrosis: A Systematic Review.

Journal Article J Pain Symptom Manage · December 2019 CONTEXT: Individuals with cystic fibrosis (CF) frequently survive into adulthood, and many have multifaceted symptoms that impair quality of life. OBJECTIVE: We conducted a systematic review to investigate opportunities to improve utilization of palliative ... Full text Link to item Cite

Introduction.

Journal Article Semin Oncol Nurs · December 2019 Full text Link to item Cite

Shared Decision-making in Acute Myeloid Leukemia.

Journal Article Semin Oncol Nurs · December 2019 OBJECTIVES: Shared decision-making (SDM) is the gold standard approach to cancer treatment decision-making in the 21st century, but it is frequently misunderstood, and many clinicians do not know how to operationalize the SDM framework in their busy practi ... Full text Link to item Cite

Integration of Palliative Care into Acute Myeloid Leukemia Care.

Journal Article Semin Oncol Nurs · December 2019 OBJECTIVE: To provide an overview of the past, present, and future of the integration of palliative care services for patients with hematologic malignancies, such as acute myeloid leukemia (AML). DATA SOURCES: Published literature as indexed in Medline, re ... Full text Link to item Cite

Billed Palliative Care Services and End-of-Life Care in Patients with Hematologic Malignancies

Conference Blood · November 13, 2019 Background: Patients with hematologic malignancies often receive aggressive care at the end of life (EOL), leading to lower quality of life. Access to early palliative care may improve EOL care outcomes, its benefits are less well established in he ... Full text Cite

Incidence of Invasive Fungal Infections in Acute Leukemia Patients Utilizing Micafungin Prophylaxis Compared to Second-Generation Azole Prophylaxis

Conference Blood · November 13, 2019 Introduction/Background:Standard therapy for both acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL) is myelosuppressive, and patients are expected to be neutropenic for a prolonged period. Due to t ... Full text Cite

Treatment Decision Making in AML: Factors of Importance to Clinicians, AML Patients and Their Family

Conference Blood · November 13, 2019 INTRODUCTION: Acute myeloid leukemia (AML) is a rare hematologic cancer primarily affecting older people, with a median age at diagnosis of 67 years old (Almeida & Ramos, 2016). Heterogeneity in the presentation, functional status and presence ... Full text Cite

Cancer-Related Distress and Unmet Needs Among Acute Myeloid Leukemia Survivors

Conference Blood · November 13, 2019 Background: Individuals with acute myeloid leukemia (AML) are at risk for significant physical and psychological burden related to their illness. While overall survival rates are improving, treatments may be associated with lengthy hospitalizations ... Full text Cite

Oral Adherence in Adults with Acute Myeloid Leukemia: Results of a Mixed Methods Study

Conference Blood · November 13, 2019 BACKGROUND: The incidence of AML is increasing, in part due to the overall aging population; median age at presentation is 67 years. Overall 5-year survival rates are as low as 5%-10% in adults >60 years (Wang, 2014). While standard treatment fo ... Full text Cite

Real-World Treatment Patterns and Overall Survival Among Medicare Fee-for-Service Beneficiaries Newly Diagnosed with Peripheral T-Cell Lymphoma

Conference Blood · November 13, 2019 Background: Peripheral T-cell lymphomas (PTCL) are a rare and heterogeneous group of lymphoid malignancies characterized by a clinically aggressive course with poor prognosis. A majority of PTCL patients are ≥60 years of age and typically present w ... Full text Cite

Understanding Clinician and Patient Preferences about Novel Agents in Chronic Lymphocytic Leukemia

Conference Blood · November 13, 2019 Introduction: Chronic lymphocytic leukemia (CLL) is an indolent disease most common in elderly adults. While chemo-immunotherapy is a standard first-line (1L) therapy for physically fit patients, treatment options for all CLL patients have greatly ... Full text Cite

Top Ten Tips Palliative Care Clinicians Should Know About Caring for Patients with Hematologic Malignancies.

Journal Article J Palliat Med · November 2019 Hematologic malignancies differ in several important ways from solid organ cancers, and warrant a unique approach to palliative care (PC) integration. As PC has moved upstream from end-of-life care, PC clinicians are increasingly asked to see patients with ... Full text Link to item Cite

Palliative Care Opportunities Among Adults With Congenital Heart Disease-A Systematic Review.

Journal Article J Pain Symptom Manage · November 2019 CONTEXT: Little is known about advance care planning (ACP) and palliative care needs among adults with congenital heart disease (ACHD). OBJECTIVES: The objective of this study was to identify and synthesize studies concerning palliative care among ACHD pat ... Full text Link to item Cite

Oral adherence in adults with acute myeloid leukemia (AML): Results of a mixed methods study.

Conference Journal of Clinical Oncology · November 1, 2019 105 Background: The incidence of AML is increasing, in part due to an aging population. Amid established intravenous (IV) or subcutaneous chemotherapies , recent drug approvals have ushered in an era of oral medication (OM) appro ... Full text Cite

Real-world experience with electronic patient reported outcomes and missing items: "Don't ask me irrelevant questions".

Conference Journal of Clinical Oncology · November 1, 2019 99 Background: Electronic patient-reported outcomes (ePROs) can improve quality of life and prolong survival in patients with cancer by enhancing the detection and tracking of unmet supportive care needs. However, there remain un ... Full text Cite

Acute care and hydration due to chemotherapy-induced nausea and vomiting (CINV) among patients receiving NEPA prophylaxis for anthracycline + cyclophosphamide (AC).

Conference Journal of Clinical Oncology · November 1, 2019 112 Background: In the US, the CMS OP-35 oncology outcome measure deems 30-day post-chemotherapy acute care involving nausea and emesis (NV) or 8 other toxicities as avoidable, with studies showing 15% of > 2500 patients recei ... Full text Cite

Billed palliative care services and end-of-life care in patients with hematologic malignancies.

Conference Journal of Clinical Oncology · November 1, 2019 43 Background: Patients (pts) with hematologic malignancies (HMs) often receive aggressive care at the end of life (EOL), leading to lower quality of life. Early palliative care (PC) may improve EOL care, but its benefits are les ... Full text Cite

Integration of electronic patient-reported outcomes into clinical workflows within the Epic electronic medical record.

Conference Journal of Clinical Oncology · November 1, 2019 102 Background: Electronic patient-reported outcome measures (ePROs) offer a new strategy for symptom assessment that can improve quality of life and prolong survival in routine cancer care. However, ePRO systems are often separa ... Full text Cite

Living with multiple myeloma: A life disrupted.

Conference Journal of Clinical Oncology · November 1, 2019 95 Background: Multiple myeloma (MM) an incurable cancer of the plasma cells is the second most common hematologic malignancy. Over 30,000 new diagnoses and over 12,000 deaths are attributed to MM annually in the United States. D ... Full text Cite

A prototype mobile application to improve communication about symptom management.

Conference Journal of Clinical Oncology · November 1, 2019 27 Background: Cancer patients report many physical and emotional symptoms which can go unreported and underestimated resulting in unmet needs. Research suggests systematic collection of symptom data is associated with decreased ... Full text Cite

Digital Supportive Care Awareness and Navigation (D-SCAN): Results of a pilot randomized trial.

Conference Journal of Clinical Oncology · November 1, 2019 101 Background: Cancer patients face many supportive care needs. In crowded clinics with rising care complexity, clinicians struggle to assess and manage these needs. Duke Cancer Patient Support Program (DCPSP) services aim to br ... Full text Cite

Pruritus in patients with solid tumors: an overlooked supportive care need.

Journal Article Support Care Cancer · October 2019 PURPOSE: Pruritus is a common symptom in cutaneous malignancies, but its impact on patients with solid tumors is unclear. We explored the impact and management of pruritus in patients with solid tumors, using patient-reported outcomes (PRO) data from a rea ... Full text Link to item Cite

Quality of life and mood of older patients with acute myeloid leukemia (AML) receiving intensive and non-intensive chemotherapy.

Journal Article Leukemia · October 2019 Older patients with AML face difficult treatment decisions as they can be treated either with 'intensive' chemotherapy requiring prolonged hospitalization, or 'non-intensive' chemotherapy. Although clinicians often perceive intensive chemotherapy as more b ... Full text Link to item Cite

Review of the patient-centered communication landscape in multiple myeloma and other hematologic malignancies.

Journal Article Patient Educ Couns · September 2019 OBJECTIVES: To identify factors limiting and facilitating patient-centered communication (PCC) in the United States hematology-oncology setting, with a focus on multiple myeloma (MM), given the limited attention to PCC and rapid pace of change that has tak ... Full text Link to item Cite

Associations between Anxiety, Poor Prognosis, and Accurate Understanding of Scan Results among Advanced Cancer Patients.

Journal Article J Palliat Med · August 2019 Background: Routine imaging ("scan") results contain key prognostic information for advanced cancer patients. Yet, little is known about how accurately patients understand this information, and whether psychological states relate to accurate understanding. ... Full text Link to item Cite

Patient-reported distress in Hodgkin lymphoma across the survivorship continuum.

Journal Article Support Care Cancer · July 2019 PURPOSE: Hodgkin lymphoma (HL) survivors face long-term, elevated risk of treatment-related sequelae, including psychosocial distress associated with poor health outcomes. The magnitude and sources of distress are not well described in the routine care of ... Full text Link to item Cite

Patient-Reported Outcomes for Cancer Patients Receiving Checkpoint Inhibitors: Opportunities for Palliative Care-A Systematic Review.

Journal Article J Pain Symptom Manage · July 2019 CONTEXT: Immune checkpoint inhibitors (ICIs) are increasingly used to treat a variety of cancers, but comparatively little is known about patient-reported outcomes (PROs) and health-related quality of life (HRQoL) among patients receiving these novel thera ... Full text Link to item Cite

Introduction to a New Special Series for the Journal of Pain and Symptom Management-Science in Action: Evidence and Opportunities for Palliative Care Across Diverse Populations and Care Settings.

Journal Article J Pain Symptom Manage · July 2019 Practices to optimize palliative care delivery and new opportunities in which to integrate palliative care vary across populations and care settings. Systematic reviews are an efficient and methodologically rigorous approach to summarize existing research ... Full text Link to item Cite

Korean Physicians' Perspectives on Prognostication in Palliative Care: A Qualitative Study.

Journal Article Am J Hosp Palliat Care · June 2019 BACKGROUND: Prognostication is an essential component of palliative care for patients with advanced cancer but also poses challenges. Little is known about physicians' perspectives on prognostication and prognostic tools used in palliative care practice in ... Full text Link to item Cite

Caregiver-guided pain coping skills training for patients with advanced cancer: Background, design, and challenges for the CaringPals study.

Journal Article Clin Trials · June 2019 BACKGROUND/AIMS: Pain is a major concern of patients with advanced cancer and their caregivers. There is strong evidence that pain coping skills training interventions based on cognitive-behavioral principles can reduce pain severity and pain interference. ... Full text Link to item Cite

Acute Myeloid Leukemia, Version 3.2019, NCCN Clinical Practice Guidelines in Oncology.

Journal Article J Natl Compr Canc Netw · June 1, 2019 Acute myeloid leukemia (AML) is the most common form of acute leukemia among adults and accounts for the largest number of annual deaths due to leukemias in the United States. Recent advances have resulted in an expansion of treatment options for AML, espe ... Full text Link to item Cite

Ondansetron versus palonosetron as a marker of non-adherence to antiemetic prophylaxis guidelines in highly emetogenic chemotherapy.

Conference Journal of Clinical Oncology · May 20, 2019 e23108 Background: ASCO antiemetic guidelines recommend upfront triple prophylaxis (NK1 receptor antagonist (RA) + 5HT3 RA + dexamethasone) for patients receiving highly emetogenic chemotherapy (HEC). Physicians exhibit high vari ... Full text Cite

Assessing the Impact of a Novel Integrated Palliative Care and Medical Oncology Inpatient Service on Health Care Utilization before Hospice Enrollment.

Journal Article J Palliat Med · April 2019 BACKGROUND: Evidence increasingly supports the integration of specialist palliative care (PC) into routine cancer care. A novel, fully integrated PC and medical oncology inpatient service was developed at Duke University Hospital in 2011. OBJECTIVE: To ass ... Full text Link to item Cite

Preventing chemotherapy-induced nausea and vomiting with netupitant/palonosetron, the first fixed combination antiemetic: current and future perspective.

Journal Article Future Oncol · April 2019 Chemotherapy-induced nausea and vomiting (CINV) can be prevented in most patients receiving appropriate antiemetic treatment. However, inadequate uptake of current antiemetic guideline recommendations by physicians, and poor treatment adherence by patients ... Full text Link to item Cite

Shifting paradigms in the treatment of older adults with AML.

Journal Article Semin Hematol · April 2019 The treatment of acute myeloid leukemia has been associated with dismal outcomes despite available therapies. The morbidity and mortality associated with acute myeloid leukemia (AML) are most profound in older patients who account for the majority of cases ... Full text Link to item Cite

Prognostication and Communication in Oncology.

Journal Article J Oncol Pract · April 2019 Full text Link to item Cite

Abstract P4-16-05: Avoidable acute care use associated with nausea and emesis among patients receiving AC, carboplatin, or cisplatin for breast cancer

Conference Cancer Research · February 15, 2019 AbstractBackground: In order to improve care and reduce costs of cancer treatment, attention has focused on reducing inpatient (IP) and emergency room (ED) utilization. The US Centers for Medicare and Medica ... Full text Cite

Disparities in place of death for patients with hematological malignancies, 1999 to 2015.

Journal Article Blood Adv · February 12, 2019 Patients with hematologic malignancies (HMs) often receive aggressive end-of-life care and less frequently use hospice. Comprehensive longitudinal reporting on place of death, a key quality indicator, is lacking. Deidentified death certificate data were ob ... Full text Link to item Cite

The experiences of older caregivers of cancer patients following hospital discharge.

Journal Article Support Care Cancer · February 2019 PURPOSE: This study addressed the experiences of older caregivers of cancer patients in the 2 weeks following a hospital discharge. It sought to understand the challenges they face in providing supportive care to patients at home. METHODS: Qualitative desc ... Full text Link to item Cite

Patient-Clinician Discordance in Perceptions of Treatment Risks and Benefits in Older Patients with Acute Myeloid Leukemia.

Journal Article Oncologist · February 2019 BACKGROUND: Older patients (≥60 years) with acute myeloid leukemia (AML) face difficult decisions regarding treatment with "intensive" chemotherapy that carries significant toxicity for a small chance of a cure versus "nonintensive" chemotherapy to control ... Full text Link to item Cite

Integrated outpatient palliative care for patients with advanced cancer: A systematic review and meta-analysis.

Journal Article Palliat Med · February 2019 BACKGROUND:: Despite increasing emphasis on integration of palliative care with disease-directed care for advanced cancer, the nature of this integration and its effects on patient and caregiver outcomes are not well-understood. AIM:: We evaluated the effe ... Full text Link to item Cite

Potentially avoidable acute care use among patients receiving oxaliplatin.

Conference Journal of Clinical Oncology · February 1, 2019 651 Background: Oxaliplatin (OX), used primarily in gastrointestinal cancers, is considered moderately emetogenic while multiple guidelines classify carboplatin and cisplatin as highly emetogenic chemotherapy (HEC). The new oncol ... Full text Cite

Let's Talk About Those Herbs You Are Taking: Ethical Considerations for Communication With Patients With Cancer About Complementary and Alternative Medicine.

Journal Article J Oncol Pract · January 2019 Oncologists face ethical challenges when patients use potentially harmful complementary and alternative medicine in addition to or instead of conventional treatments for their cancer. For example, a patient may forego effective cancer treatment in favor of ... Full text Link to item Cite

What do transplant physicians think about palliative care? A national survey study.

Conference Cancer · December 1, 2018 BACKGROUND: Despite its established benefits, palliative care (PC) is rarely utilized for hematopoietic stem cell transplant (HSCT) patients. We sought to examine transplant physicians' perceptions of PC. METHODS: We conducted a cross-sectional survey of t ... Full text Link to item Cite

Hemato-oncology and palliative care teams: is it time for an integrated approach to patient care?

Journal Article Curr Opin Support Palliat Care · December 2018 PURPOSE OF REVIEW: Integrated palliative care for those with advanced solid tumors yields significant benefits in patient and caregiver outcomes. However, most palliative care clinical trials have excluded patients with hematologic malignancies. There is g ... Full text Link to item Cite

Quality of life and psychological distress in patients with acute myeloid leukemia (AML).

Conference Journal of Clinical Oncology · December 1, 2018 154 Background: Older patients with AML face difficult treatment decisions as they can be treated either with multi-drug ‘intensive’ chemotherapy requiring a prolonged hospitalization, or ‘non-intensive’ chemotherapy. Although cl ... Full text Cite

Palliative care physicians' beliefs toward hematology and the care of patients with hematologic diseases: Results of a nationwide survey.

Conference Journal of Clinical Oncology · December 1, 2018 95 Background: Palliative care (PC) specialists provide supportive care for patients with hematologic diseases (HD). However, the degree of engagement by PC physicians may be limited by the views of both PC physicians & hemat ... Full text Cite

What the HEC? Physician variation and attainable compliance targets in antiemetic prophylaxis.

Conference Journal of Clinical Oncology · December 1, 2018 74 Background: U.S. National Antiemetic Guidelines recommend upfront triple prophylaxis (NK1 receptor antagonist (RA) + 5HT3 RA + dexamethasone) for patients receiving highly emetogenic chemotherapy (HEC), including carboplatin A ... Full text Cite

Sleep Disturbance Among Individuals with Multiple Myeloma: The Interplay between Physical and Psychosocial Symptoms

Conference Blood · November 29, 2018 AbstractBackground: As long-term survival rates for multiple myeloma (MM) improve, and patients receive more prolonged courses of treatment, individuals living with MM experience cumulative physical symptom ... Full text Cite

Treatment Decision Making and Treatment Satisfaction Among Individuals Living with Chronic Myeloid Leukemia

Conference Blood · November 29, 2018 AbstractBackground: Over the past decade, an increase in treatment options for chronic myeloid leukemia (CML) has dramatically changed the therapeutic landscape and has improved cli ... Full text Cite

End-of-Life Care Quality Outcomes Among Medicare Beneficiaries with Hematologic Malignancies

Conference Blood · November 29, 2018 AbstractBackground: Benefits of hospice care for patients with advanced solid cancers have been extensively studied, but they have not been comprehensively documented in hematologic malignancies (HM). Survey ... Full text Cite

Palliative Care Physicians' Views Toward Hematology and the Care of Patients with Hematologic Diseases: Results of a Nationwide Survey

Conference Blood · November 29, 2018 AbstractBackground: Palliative care specialists provide supportive care for patients with hematologic diseases. However, the degree of engagement by palliative care physicians may b ... Full text Cite

Predictors of Patient-Reported Communication with Their Health Care Team about New Treatment Options for Chronic Lymphocytic Leukemia

Conference Blood · November 29, 2018 AbstractBackground: Chronic lymphocytic leukemia (CLL) progresses with time and, as a result, patients can be challenged by considering multiple treatment options. Importantly, over ... Full text Cite

Management of cancer pain

Chapter · November 16, 2018 Cite

Place of death for patients with cancer in the United States, 1999 through 2015: Racial, age, and geographic disparities.

Journal Article Cancer · November 15, 2018 BACKGROUND: Place of death is an essential component of high quality cancer care and comprehensive national trends and disparities in place of death are unknown. METHODS: Deidentified death certificate data were obtained via the National Center for Health ... Full text Link to item Cite

Actigraphy assessment of sleep quality among patients with acute myeloid leukaemia during induction chemotherapy.

Journal Article BMJ Support Palliat Care · September 2018 OBJECTIVES: Patients receiving induction chemotherapy for acute myeloid leukaemia (AML) anecdotally describe poor sleep, but sleep disturbances have not been well-characterised in this population. We aimed to test the feasibility of measuring sleep quality ... Full text Link to item Cite

Palliative Performance Scale Score at 1 Week After Palliative Care Unit Admission is More Useful for Survival Prediction in Patients With Advanced Cancer in South Korea.

Journal Article Am J Hosp Palliat Care · September 2018 BACKGROUND: The Palliative Performance Scale (PPS) is a useful prognostic index in palliative care. Changes in PPS score over time may add useful prognostic information beyond a single measurement. OBJECTIVE: To investigate the usefulness of repeated PPS m ... Full text Link to item Cite

Transfusion dependence, use of hospice services, and quality of end-of-life care in leukemia.

Journal Article Blood · August 16, 2018 Hospice provides high-quality end-of-life care, but patients with leukemias use hospice services less frequently than those with solid tumors. Transfusion dependence (TD) may hinder or delay enrollment, because hospice organizations typically disallow tran ... Full text Link to item Cite

Evidence-based Management of Cancer Pain.

Journal Article Semin Oncol Nurs · August 2018 OBJECTIVE: To provide a brief review of common palliative care practices in the assessment and management of cancer pain for practicing oncology nurses. DATA SOURCES: Published literature as indexed in Medline, relevant guideline documents, textbooks, and ... Full text Link to item Cite

The Surprise Question and Identification of Palliative Care Needs among Hospitalized Patients with Advanced Hematologic or Solid Malignancies.

Journal Article J Palliat Med · June 2018 BACKGROUND: Little is known about quality of life (QOL), depression, and end-of-life (EOL) outcomes among hospitalized patients with advanced cancer. OBJECTIVE: To assess whether the surprise question identifies inpatients with advanced cancer likely to ha ... Full text Link to item Cite

Information Framing Reduces Initial Negative Attitudes in Cancer Patients' Decisions About Hospice Care.

Journal Article J Pain Symptom Manage · June 2018 BACKGROUND: Negative attitudes toward hospice care might prevent patients with cancer from discussing and choosing hospice as they approach end of life. When making a decision, people often naturally focus on either expected benefits or the avoidance of ha ... Full text Link to item Cite

Pain Syndromes and Management in Adult Hematopoietic Stem Cell Transplantation.

Journal Article Hematol Oncol Clin North Am · June 2018 Pain is a significant physical symptom that can be observed across the spectrum of hematopoietic stem cell transplant (HSCT) care. Pain assessment should include evaluation of the physical and functional components of pain. Management varies based on the t ... Full text Link to item Cite

"How Much Time Do I Have?": Communicating Prognosis in the Era of Exceptional Responders.

Journal Article Am Soc Clin Oncol Educ Book · May 23, 2018 Prognostication is the science by which clinicians estimate a patient's expected outcome. A robust literature shows that many patients with advanced cancer have inaccurate perceptions of their prognosis, thus raising questions about whether patients are tr ... Full text Link to item Cite

Psychological distress in myelodysplastic syndromes.

Conference Journal of Clinical Oncology · May 20, 2018 Full text Cite

The impact of remission status on patients' experiences with acute myeloid leukemia (AML): an exploratory analysis of longitudinal patient-reported outcomes data.

Journal Article Support Care Cancer · May 2018 PURPOSE: Shared decision-making in acute myeloid leukemia (AML) requires understanding patients' longitudinal experiences of illness, but little is known about the impact of remission status on patient-reported outcomes (PROs). We aimed to explore the asso ... Full text Link to item Cite

A Cohort Study of Patient-Reported Outcomes and Healthcare Utilization in Acute Myeloid Leukemia Patients Receiving Active Cancer Therapy in the Last Six Months of Life.

Journal Article J Palliat Med · May 2018 BACKGROUND: Evidence about the unique palliative care needs of patients with acute myeloid leukemia (AML) is limited. Improving the care of these patients will require a better understanding of their unmet needs, including symptom burden at the end of life ... Full text Link to item Cite

Top Ten Tips for Palliative Care Clinicians Caring for Cancer Patients Receiving Immunotherapies.

Journal Article J Palliat Med · May 2018 Patients with cancer face an ever-changing landscape of tumor-directed therapies available to improve quality of life and potentially increase survival. The most recent advances, immunotherapeutics, offer a novel way to target cancer cells by engaging the ... Full text Link to item Cite

Triadic treatment decision-making in advanced cancer: a pilot study of the roles and perceptions of patients, caregivers, and oncologists.

Journal Article Support Care Cancer · April 2018 PURPOSE: The research on cancer treatment decision-making focuses on dyads; the full "triad" of patients, oncologists, and caregivers remains largely unstudied. We investigated how all members of this triad perceive and experience decisions related to trea ... Full text Link to item Cite

Open Oncology Notes: A Qualitative Study of Oncology Patients' Experiences Reading Their Cancer Care Notes.

Journal Article J Oncol Pract · April 2018 PURPOSE: Electronic medical records increasingly allow patients access to clinician notes. Although most believe that open notes benefits patients, some suggest negative consequences. Little is known about the experiences of patients with cancer reading th ... Full text Link to item Cite

Patient-Reported Distress in Myelodysplastic Syndromes and Its Association With Clinical Outcomes: A Retrospective Cohort Study.

Journal Article J Natl Compr Canc Netw · March 2018 Background: NCCN defines distress as a multifactorial, unpleasant emotional experience of a psychological nature that may interfere with patients' ability to cope with cancer symptoms and treatment. Patients with myelodysplastic syndromes (MDS) are at risk ... Full text Link to item Cite

A National Survey Study of Transplant Physicians' Attitudes About Palliative Care

Conference BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION · March 1, 2018 Link to item Cite

Development of a digital patient navigation application: Preliminary results from patient interviews.

Conference Journal of Clinical Oncology · March 1, 2018 161 Background: People living with cancer face challenges too numerous to attend to during brief clinic visits, and thus may benefit from additional help with supportive care needs. While patient navigators offer promise, they ar ... Full text Cite

Perceptions of unintentional weight loss among cancer survivors.

Conference Journal of Clinical Oncology · March 1, 2018 138 Background: Unintentional weight loss (WL) can be a disruptive symptom of cancer, yet its psychosocial impact is not well understood. We examined cancer survivors’ experiences with unintentional WL. Methods: 320 cancer surviv ... Full text Cite

Acute Leukemia Patients' Needs: Qualitative Findings and Opportunities for Early Palliative Care.

Journal Article J Pain Symptom Manage · February 2018 CONTEXT: Patients with acute leukemias likely have needs that palliative care can respond to, yet little is known about specific challenges they face, particularly during active treatment. We examined acute myeloid leukemia (AML) patients' expressed challe ... Full text Link to item Cite

Comparing the Palliative Care Needs of Patients With Hematologic and Solid Malignancies.

Journal Article J Pain Symptom Manage · January 2018 CONTEXT: Hematologic cancer patients use palliative care services less frequently than their solid tumor counterparts. Prior work suggests that these patients have a sizable symptom burden, but comparisons between hematologic and solid tumor patients near ... Full text Link to item Cite

Patient experiences of acute myeloid leukemia: A qualitative study about diagnosis, illness understanding, and treatment decision-making.

Conference Psychooncology · December 2017 BACKGROUND: Patients with acute myeloid leukemia (AML) face a unique, difficult situation characterized by sudden changes in health, complex information, and pressure to make quick treatment decisions amid sizeable tradeoffs. Yet, little is known about pat ... Full text Link to item Cite

Patient-reported outcomes in cancer care - hearing the patient voice at greater volume.

Journal Article Nat Rev Clin Oncol · December 2017 Recording of patient-reported outcomes (PROs) enables direct measurement of the experiences of patients with cancer. In the past decade, the use of PROs has become a prominent topic in health-care innovation; this trend highlights the role of the patient e ... Full text Link to item Cite

Effect of Inpatient Palliative Care During Hematopoietic Stem-Cell Transplant on Psychological Distress 6 Months After Transplant: Results of a Randomized Clinical Trial.

Journal Article J Clin Oncol · November 10, 2017 Purpose Inpatient palliative care integrated with transplant care improves patients' quality of life (QOL) and symptom burden during hematopoietic stem-cell transplant (HCT). We assessed patients' mood, post-traumatic stress disorder (PTSD) symptoms, and Q ... Full text Link to item Cite

The Implementation of Measuring What Matters in Research and Practice: Series Commentary.

Journal Article J Pain Symptom Manage · November 2017 The Measuring What Matters (MWM) initiative identified 10 indicators of high-quality palliative and hospice care. Members of the AAHPM Research Committee, through a special series of articles, examined applications of the MWM quality indicators in research ... Full text Link to item Cite

Use of hospice services among Medicare beneficiaries with acute and chronic leukemias.

Conference Journal of Clinical Oncology · November 1, 2017 68 Background: Studies show lower rates of hospice use among patients (pts) with hematologic malignancies. Our objective was to describe trends in hospice use and in quality measures for end-of-life (EOL) care among Medicare bene ... Full text Cite

Open notes: A qualitative study of oncology patients’ experiences reading their cancer care notes.

Conference Journal of Clinical Oncology · November 1, 2017 33 Background: Electronic medical record systems and patient portals increasingly allow patients direct access to their clinicians’ notes.While most believe that open notes benefit patients, some suggest negative consequences. Li ... Full text Cite

Perceptions of prognosis and treatment risk in older patients with acute myeloid leukemia (AML).

Conference Journal of Clinical Oncology · November 1, 2017 43 Background: Older patients ( > 60 years) with AML face difficult treatment decisions as they can be treated either with risky multi-drug “intensive” chemotherapy for a small chance of a cure, or “non-intensive” and non-cura ... Full text Cite

Integration of Electronic Patient-Reported Outcomes Into Routine Cancer Care: An Analysis of Factors Affecting Data Completeness.

Journal Article JCO Clin Cancer Inform · November 2017 PURPOSE: Routinely collected patient-reported outcomes (PROs) could provide invaluable data to a patient-centered learning health system but are often highly missing in clinical trials. We analyzed our experience with PROs to understand patterns of missing ... Full text Link to item Cite

The Prospective Evaluation of the Net Effect of Red Blood Cell Transfusions in Routine Provision of Palliative Care.

Journal Article J Palliat Med · October 2017 BACKGROUND: Red Blood Cell (RBC) transfusions are commonly used in palliative care. RBCs are a finite resource, transfusions carry risks, and the net effect (benefits and harms) is poorly defined for people with life-limiting illnesses. OBJECTIVE: To exami ... Full text Link to item Cite

Ethics Never Left.

Journal Article J Oncol Pract · October 2017 Full text Link to item Cite

Improvements in Patient and Health System Outcomes Using an Integrated Oncology and Palliative Medicine Approach on a Solid Tumor Inpatient Service.

Journal Article J Oncol Pract · September 2017 PURPOSE: Early palliative care (PC) improves outcomes for outpatients with advanced cancer. Its effect on hospitalized patients with cancer is unknown. Herein, we report on the influence of a novel, fully integrated inpatient medical oncology and PC partne ... Full text Link to item Cite

Palliative Care Has Come of Age.

Journal Article J Oncol Pract · September 2017 Full text Link to item Cite

The Cambia Sojourns Scholars Leadership Program: Conversations with Emerging Leaders in Palliative Care.

Journal Article J Palliat Med · August 2017 BACKGROUND: There is a pressing workforce shortage and leadership scarcity in palliative care to adequately meet the demands of individuals with serious illness and their families. To address this gap, the Cambia Health Foundation launched its Sojourns Sch ... Full text Link to item Cite

Early Palliative Care for Patients with Hematologic Malignancies: Is It Really so Difficult to Achieve?

Journal Article Curr Hematol Malig Rep · August 2017 Evidence points to many benefits of "early palliative care," the provision of specialist palliative care services upstream from the end of life, to improve patients' quality of life while living with a serious illness. Yet most trials of early palliative c ... Full text Link to item Cite

Risk tolerance and attitudes toward chemotherapy: Who chooses palliative treatment when cure is possible?

Conference Journal of Clinical Oncology · May 20, 2017 10054 Background: Many patients with acute myeloid leukemia (AML) face a difficult choice about whether to receive palliative chemotherapy or high-dose, potentially-curative chemotherapy that poses a risk of early death. How peop ... Full text Cite

Patient-reported distress in myelodysplastic syndromes and its relationship with clinical outcomes.

Conference Journal of Clinical Oncology · May 20, 2017 e21564 Background: The National Comprehensive Cancer Network (NCCN) defines distress as an unpleasant emotional experience associated with the psychosocial complications of cancer. Patients with myelodysplastic syndromes (MDS) ar ... Full text Cite

Assessing Psychological Toxicity and Patient-Reported Distress as the Sixth Vital Sign in Cancer Care and Clinical Trials.

Journal Article AMA J Ethics · May 1, 2017 As the number of available cancer therapies continues to grow, there is increasing interest in their impact on cancer patients' lived experiences. Screening for distress is one way to measure psychological dimensions of cancer patients' experiences, and do ... Full text Link to item Cite

Harmonization of patient-reported outcomes into EHRs at four cancer hospital outpatient clinics for patient care and quality assessment.

Conference Journal of Clinical Oncology · March 10, 2017 129 Background: Patient-reported outcome (PRO) measures are well established in oncology trials but are not collected systematically during clinical care, to guide symptom management, or to assess quality. A growing body of evide ... Full text Cite

Operationalizing the Measuring What Matters Spirituality Quality Metric in a Population of Hospitalized, Critically Ill Patients and Their Family Members.

Journal Article J Pain Symptom Manage · March 2017 CONTEXT: Measuring What Matters (MWM) quality indicators support measurement of the percentage of patients who have spiritual discussions, if desired. OBJECTIVES: The objective of this study was to 1) determine the ease of, and barriers to, prospectively c ... Full text Link to item Cite

Concordance Between Veterans' Self-Report and Documentation of Surrogate Decision Makers: Implications for Quality Measurement.

Journal Article J Pain Symptom Manage · January 2017 CONTEXT: The Measuring What Matters initiative of the American Academy of Hospice and Palliative Medicine and the Hospice and Palliative Nurses Association identified documentation of a surrogate decision maker as one of the top 10 quality indicators in th ... Full text Link to item Cite

Palliative and End-of-Life Care in Myelodysplastic Syndromes.

Journal Article Curr Hematol Malig Rep · December 2016 A growing literature demonstrates that MDS is associated with significant impairments in overall quality of life. Given the poor prognosis for many patients with MDS, and the considerable morbidities associated with this disease, there is a critical need t ... Full text Link to item Cite

Adherence to Measuring What Matters Items When Caring for Patients With Hematologic Malignancies Versus Solid Tumors.

Journal Article J Pain Symptom Manage · December 2016 CONTEXT: Measuring What Matters (MWM) prioritizes quality measures in palliative care practice. Hematologic malignancy patients are less likely to access palliative care, yet little is known about their unique needs. Differences in MWM adherence may highli ... Full text Link to item Cite

Risk stratification, treatment selection, and transplant eligibility in multiple myeloma: a qualitative study of the perspectives and self-reported practices of oncologists.

Journal Article Curr Oncol · December 2016 BACKGROUND: Since the early 2000s, treatment options for multiple myeloma have rapidly expanded, adding significant complexity to the management of this disease. To our knowledge, no systematic qualitative research on clinical decision-making in multiple m ... Full text Link to item Cite

Effect of Inpatient Palliative Care on Quality of Life 2 Weeks After Hematopoietic Stem Cell Transplantation: A Randomized Clinical Trial.

Journal Article JAMA · November 22, 2016 IMPORTANCE: During hospitalization for hematopoietic stem cell transplantation (HCT), patients receive high-dose chemotherapy before transplantation and experience significant physical and psychological symptoms and poor quality of life (QOL). OBJECTIVE: T ... Full text Link to item Cite

Anticholinergic Drug Burden in Noncancer Versus Cancer Patients Near the End of Life.

Journal Article J Pain Symptom Manage · November 2016 CONTEXT: Anticholinergic drugs can cause several side effects, impairing cognition and quality of life (QOL). Cancer patients are often exposed to increasing cumulative anticholinergic load (ACL) as they approach death, but this burden has not been examine ... Full text Link to item Cite

Cancer Cachexia: Beyond Weight Loss.

Journal Article J Oncol Pract · November 2016 Cancer cachexia is a multifactorial syndrome characterized by skeletal muscle loss leading to progressive functional impairment. Despite the ubiquity of cachexia in clinical practice, prevention, early identification, and intervention remain challenging. T ... Full text Link to item Cite

Inpatient integrated palliative and transplant care to improve family caregiver (FC) outcomes of patients hospitalized for hematopoietic stem cell transplantation (HCT).

Conference Journal of Clinical Oncology · October 9, 2016 235 Background: As their loved ones struggle physically and psychologically with transplant toxicities, FCs of patients undergoing HCT experience substantial distress. We assessed the impact of an inpatient palliative care interv ... Full text Cite

Sleep quality among inpatients with acute myeloid leukemia.

Conference Journal of Clinical Oncology · October 9, 2016 82 Background: Anecdotally, sleep is thought to be a significant problem for inpatients receiving treatment for acute myeloid leukemia (AML), butsleep disturbances in this setting are not well-characterized. We aimed to assess th ... Full text Cite

Patient-reported distress in adults with myelodysplastic syndromes (MDS).

Conference Journal of Clinical Oncology · October 9, 2016 80 Background: MDS are hematopoietic malignancies that are incurable in most patients. The National Comprehensive Cancer Network (NCCN) defines distress as an unpleasant emotional experience associated with the psychosocial compl ... Full text Cite

Who chooses palliative chemotherapy when a cure is possible? Results of a risk tolerance survey of laypersons.

Conference Journal of Clinical Oncology · October 9, 2016 35 Background: Many patients with acute myeloid leukemia (AML) face a difficult choice about whether to receive palliative chemotherapy or high-dose, potentially-curative chemotherapy that poses a risk of early death. How people ... Full text Cite

Randomized trial of inpatient palliative care in patients hospitalized for hematopoietic stem cell transplantation (HCT).

Conference Journal of Clinical Oncology · October 9, 2016 103 Background: During HCT, patients experience physical and psychological symptoms that negatively impact their quality of life (QOL). We assessed the impact of an inpatient palliative care intervention on patient QOL, symptom b ... Full text Cite

Association of Practice-Level Hospital Use With End-of-Life Outcomes, Readmission, and Weekend Hospitalization Among Medicare Beneficiaries With Cancer.

Journal Article J Oncol Pract · October 2016 PURPOSE: To determine the relationships between hospital use of treating oncology practices and patient outcomes. PATIENTS AND METHODS: Retrospective analysis of 397,646 Medicare beneficiaries who received anticancer therapy in 2012. Each beneficiary was a ... Full text Link to item Cite

Pretransplantation Supportive and Palliative Care Consultation for High-Risk Hematopoietic Cell Transplantation Patients.

Journal Article Biol Blood Marrow Transplant · July 2016 Early palliative care (EPC) for patients with metastatic solid tumors is now standard of care, but the effect of EPC in hematopoietic cell transplantation (HCT) is less well understood. We studied the acceptability of pre-HCT EPC as measured by trial parti ... Full text Link to item Cite

Assessing Emotional Suffering in Palliative Care: Use of a Structured Note Template to Improve Documentation.

Journal Article J Pain Symptom Manage · July 2016 CONTEXT: Documentation of the emotional or psychological needs of seriously ill patients receiving specialty palliative care is endorsed by the "Measuring What Matters" project as a quality performance metric and recommended for use by hospice and palliati ... Full text Link to item Cite

Potentially avoidable hospital admissions in older patients with acute myeloid leukaemia in the USA: a retrospective analysis.

Journal Article Lancet Haematol · June 2016 BACKGROUND: Older adults (≥60 years of age) with acute myeloid leukaemia spend a substantial proportion of their life in hospital after diagnosis. We examined reasons for their hospital admissions and identified potentially avoidable hospital admissions (P ... Full text Link to item Cite

Shared decision-making tools for patients with hematologic malignancies.

Conference Journal of Clinical Oncology · May 20, 2016 Full text Cite

An Exploratory Factor Analysis of the Scale Structure of the Patient Care Monitor Version 2.0.

Journal Article J Pain Symptom Manage · April 2016 CONTEXT: The Patient Care Monitor (PCM), version 2.0, is an electronic patient-reported outcomes instrument designed to be embedded into oncology practices. One key psychometric component of an instrument is its factor structure. OBJECTIVES: To validate th ... Full text Link to item Cite

A practical measurement of thoracic sarcopenia: correlation with clinical parameters and outcomes in advanced lung cancer.

Journal Article ERJ Open Res · April 2016 Thoracic sarcopenia can feasibly be measured from routine CT scans but does not correlate to patient-centred outcomes http://ow.ly/102UkQ. ... Full text Open Access Link to item Cite

Concordance of Advance Care Plans With Inpatient Directives in the Electronic Medical Record for Older Patients Admitted From the Emergency Department.

Journal Article J Pain Symptom Manage · April 2016 CONTEXT: Measuring What Matters identified quality indicators to examine the percentage of patients with documentation of a surrogate decision maker and preferences for life-sustaining treatments. OBJECTIVES: To determine the rate of advance care planning ... Full text Link to item Cite

Palliative chemotherapy: oxymoron or misunderstanding?

Journal Article BMC Palliat Care · March 21, 2016 Oncologists routinely prescribe chemotherapy for patients with advanced cancer. This practice is sometimes misunderstood by palliative care clinicians, yet data clearly show that chemotherapy can be a powerful palliative intervention when applied appropria ... Full text Open Access Link to item Cite

Adherence to Measuring What Matters Measures Using Point-of-Care Data Collection Across Diverse Clinical Settings.

Journal Article J Pain Symptom Manage · March 2016 CONTEXT: Measuring What Matters (MWM) for palliative care has prioritized data collection efforts for evaluating quality in clinical practice. How these measures can be implemented across diverse clinical settings using point-of-care data collection on qua ... Full text Link to item Cite

Clinical and Immunomodulatiory Outcomes of Microtransplantation for AML

Conference Biology of Blood and Marrow Transplantation · March 2016 Full text Cite

Breakthrough cancer pain

Chapter · February 2, 2016 Full text Cite

Feeling Heard and Understood: A Patient-Reported Quality Measure for the Inpatient Palliative Care Setting.

Journal Article J Pain Symptom Manage · February 2016 CONTEXT: As endorsed by the palliative care "Measuring What Matters" initiative, capturing patients' direct assessment of their care is essential for ongoing quality reporting and improvement. Fostering an environment where seriously ill patients feel hear ... Full text Link to item Cite

Discussing the Evidence for Upstream Palliative Care in Improving Outcomes in Advanced Cancer.

Journal Article Am Soc Clin Oncol Educ Book · 2016 Palliative care has received increasing attention at the American Society of Clinical Oncology (ASCO) Annual Meeting since the publication of its provisional clinical opinion on the topic in 2012. Despite frequent discussion, palliative care remains a sour ... Full text Link to item Cite

Multiple Myeloma Patient Experience with Financial Toxicity: Findings from the Cancer Experience Registry

Conference Blood · December 3, 2015 AbstractBackground: The US prevalence of multiple myeloma (MM) is estimated at 83,118 as of January 1, 2011 (SEER, 2014), and about 24,050 new MM cases will be diagnosed in 2014 (ACS, 2014). With advances in ... Full text Cite

What bothers lung cancer patients the most? A prospective, longitudinal electronic patient-reported outcomes study in advanced non-small cell lung cancer.

Journal Article Support Care Cancer · December 2015 PURPOSE: Patients with advanced non-small cell lung cancer (aNSCLC) face a significant symptom burden. Little is known about the frequency and severity of symptoms over time, so we longitudinally characterized patients' symptoms using the Patient Care Moni ... Full text Link to item Cite

Pruritus as an unmet palliative care need in cancer patients: A retrospective cohort study of a Duke patient-reported outcomes database.

Conference Journal of Clinical Oncology · October 10, 2015 97 Background: For cancer patients, the impact of pruritus is not well known, and may be increasing in incidence and severity for those receiving targeted agents. We aimed to describe pruritus in patients with solid tumors, asses ... Full text Cite

Fatigue in long-term non-Hodgkin lymphoma survivors.

Conference Journal of Clinical Oncology · October 10, 2015 239 Background: Fatigue is a common and distressing effect of cancer and its treatment, potentially affecting quality of life (QOL) for years after treatment. However, the prevalence and persistence of fatigue among long-term sur ... Full text Cite

Severity of and contributors to distress in patients with acute myeloid leukemia (AML) receiving induction chemotherapy.

Conference Journal of Clinical Oncology · October 10, 2015 83 Background: Distress screening is a recommended component of comprehensive cancer care, and is now required as a condition of cancer center accreditation by the American College of Surgeons Commission on Cancer. However, the e ... Full text Cite

Symptom burden and palliative care for patients with multiple myeloma: Cancer Experience Registry findings.

Conference Journal of Clinical Oncology · October 10, 2015 81 Background: Multiple myeloma (MM) patients are living longer with treatment advances yet remain challenged by complications and adverse treatment effects. Concurrent oncology/palliative care can improve symptom burden and qual ... Full text Cite

Potentially avoidable hospitalizations in older patients with acute myeloid leukemia (AML).

Conference Journal of Clinical Oncology · October 10, 2015 206 Background: Many older adults ( ≥ 60) with AML have a poor prognosis and spend a significant portion of their life from diagnosis until death in the hospital. We examined the reasons for hospitalizations and identified potent ... Full text Cite

Chemotherapy Use, Performance Status, and Quality of Life at the End of Life.

Journal Article JAMA Oncol · September 2015 IMPORTANCE: Although many patients with end-stage cancer are offered chemotherapy to improve quality of life (QOL), the association between chemotherapy and QOL amid progressive metastatic disease has not been well-studied. American Society for Clinical On ... Full text Link to item Cite

Health care utilization and end-of-life care for older patients with acute myeloid leukemia.

Journal Article Cancer · August 15, 2015 BACKGROUND: Health care utilization in older adults (age ≥60 years) with acute myeloid leukemia (AML) has not been well studied. METHODS: We conducted a retrospective analysis of 330 consecutive older patients who were diagnosed with AML between May 1, 200 ... Full text Link to item Cite

Validation and real-world assessment of the Functional Assessment of Anorexia-Cachexia Therapy (FAACT) scale in patients with advanced non-small cell lung cancer and the cancer anorexia-cachexia syndrome (CACS).

Journal Article Support Care Cancer · August 2015 PURPOSE: Patients with cancer anorexia-cachexia syndrome (CACS) suffer a significant symptom burden, impaired quality of life (QoL), and shorter survival. Measurement of QoL impairments related to CACS is thereby important both in clinical practice and in ... Full text Link to item Cite

Symptom burden of haematological malignancies as death approaches in a community palliative care service: a retrospective cohort study of a consecutive case series.

Journal Article Lancet Haematol · August 2015 BACKGROUND: Patients with haematological malignancies are less likely to use palliative care services than are patients with solid tumours. This difference might stem from differing symptom burden, care needs, disease trajectories, or a combination of thes ... Full text Link to item Cite

Cancer-Related Fatigue, Version 2.2015.

Journal Article J Natl Compr Canc Netw · August 2015 Cancer-related fatigue is defined as a distressing, persistent, subjective sense of physical, emotional, and/or cognitive tiredness or exhaustion related to cancer or cancer treatment that is not proportional to recent activity and interferes with usual fu ... Full text Link to item Cite

Polypharmacy in patients with advanced cancer and the role of medication discontinuation.

Journal Article Lancet Oncol · July 2015 Polypharmacy is a well known problem in elderly patients in general, but its prevalence and effects in patients with cancer are less clear, particularly in end-of-life settings. This Review examines the existing literature on polypharmacy in advanced cance ... Full text Link to item Cite

Fatigue in long-term non-Hodgkin lymphoma survivors

Conference JOURNAL OF CLINICAL ONCOLOGY · May 20, 2015 Link to item Cite

Safety and benefit of discontinuing statin therapy in the setting of advanced, life-limiting illness: a randomized clinical trial.

Journal Article JAMA Intern Med · May 2015 IMPORTANCE: For patients with limited prognosis, some medication risks may outweigh the benefits, particularly when benefits take years to accrue; statins are one example. Data are lacking regarding the risks and benefits of discontinuing statin therapy fo ... Full text Link to item Cite

Correlation between the international consensus definition of the Cancer Anorexia-Cachexia Syndrome (CACS) and patient-centered outcomes in advanced non-small cell lung cancer.

Journal Article J Pain Symptom Manage · April 2015 CONTEXT: The cancer anorexia-cachexia syndrome (CACS) is common in patients with advanced solid tumors and is associated with adverse outcomes including poor quality of life (QOL), impaired functioning, and shortened survival. OBJECTIVES: To apply the rece ... Full text Link to item Cite

What is different about patients with hematologic malignancies? A retrospective cohort study of cancer patients referred to a hospice research network.

Journal Article J Pain Symptom Manage · March 2015 CONTEXT: Although much is known about solid tumor patients who use hospice, the hematologic malignancies hospice population is inadequately described. OBJECTIVES: To compare the characteristics and outcomes of hospice patients with hematologic malignancies ... Full text Link to item Cite

Perceptions of palliative care among hematologic malignancy specialists: a mixed-methods study.

Journal Article J Oncol Pract · March 2015 PURPOSE: Patients with hematologic malignancies are less likely to receive specialist palliative care services than patients with solid tumors. Reasons for this difference are poorly understood. METHODS: This was a multisite, mixed-methods study to underst ... Full text Link to item Cite

Demystifying Nutritional Support in Cancer (FR451)

Conference Journal of Pain and Symptom Management · February 2015 Full text Cite

Communication skills training in the twenty-first century

Journal Article AMA Journal of Ethics · February 1, 2015 Full text Cite

Management of cancer pain

Chapter · January 7, 2015 Cite

When and why should patients with hematologic malignancies see a palliative care specialist?

Journal Article Hematology Am Soc Hematol Educ Program · 2015 Palliative care is a multidisciplinary approach to symptom management, psychosocial support, and assistance in treatment decision-making for patients with serious illness and their families. It emphasizes well-being at any point along the disease trajector ... Full text Link to item Cite

Early palliative care on an inpatient oncology unit: Impact of a novel co-rounding partnership on patient and health system outcomes.

Journal Article J Clin Oncol · November 2014 3 Background: Early palliative care (PC) improves outcomes for outpatients with advanced cancer, but its impact on an inpatient oncology unit is unknown. We implemented a novel inpatient medical oncology (ONC) and PC co-rounding partnership on September 1, ... Full text Link to item Cite

Electronic Health Records (EHRs) in the oncology clinic: how clinician interaction with EHRs can improve communication with the patient.

Journal Article J Oncol Pract · September 2014 Electronic health records pose a particularly difficult problem in the oncology clinic, where difficult topics require much time and attention to address. But with careful attention, they might actually enhance communication in the clinic. ... Full text Link to item Cite

Building the palliative care evidence base: Lessons from a randomized controlled trial of oxygen vs room air for refractory dyspnea.

Journal Article J Natl Compr Canc Netw · July 2014 Palliative care is increasingly seen as a standard component of high-quality comprehensive cancer care. However, several challenges remain to its widespread integration into clinical oncology practice, including workforce problems, reimbursement concerns, ... Full text Link to item Cite

Patient understanding of medical jargon: a survey study of U.S. medical students.

Journal Article Patient Educ Couns · May 2014 OBJECTIVE: With increasing exposure, medical students may forget that technical jargon is unfamiliar to laypeople. To investigate this possibility, authors assessed student perceptions of patient understanding across different years in medical school. METH ... Full text Link to item Cite

In the sandbox: palliative care and hematologic malignancies.

Journal Article J Community Support Oncol · February 2014 Palliative care specialists have had little involvement in the care of patients with hematologic malignancies. The reasons for this are not clear, because these patients certainly face a significant symptom burden, and many hematologic malignancies are eit ... Full text Link to item Cite

Introduction

Chapter · January 1, 2014 Cite

Palliative Care For Patients With Hematologic Malignancies: A Profile Of Patients With Blood Cancers Referred To The Choice Hospice Network

Conference Blood · November 15, 2013 AbstractBackgroundPublished literature provides an incomplete description of the palliative care needs of the hematologic malignancies ... Full text Cite

Overcoming recruitment challenges in palliative care clinical trials.

Journal Article J Oncol Pract · November 2013 PURPOSE: Palliative care is increasingly viewed as a necessary component of cancer care, especially for patients with advanced disease. Rigorous clinical trials are thus needed to build the palliative care evidence base, but clinical research-especially pa ... Full text Link to item Cite

The ethics of health information technology in oncology: emerging isssues from both local and global perspectives.

Journal Article Am Soc Clin Oncol Educ Book · 2013 Health information technology (HIT) is ever-increasing in complexity and has incrementally become a fundamental part of our everyday clinical lives. As HIT becomes more complex and commonplace, so do the questions it raises about stewardship and usage of d ... Full text Link to item Cite

The message isn't as mean as we may think.

Journal Article Virtual Mentor · January 1, 2013 Full text Link to item Cite

Considerations in reporting palliative care clinical trials: standardizing information reported and authorship practices.

Journal Article Curr Opin Support Palliat Care · December 2012 PURPOSE OF REVIEW: The nature of palliative care practice, especially the reliance on referrals and differing models of service delivery, poses unique challenges for the creation and interpretation of an evidence base, frequently limiting the applicability ... Full text Link to item Cite

Autopsy and grief: a case of transformative postmortem examination.

Journal Article J Palliat Med · February 2012 BACKGROUND: A physician's obligations to deliver compassionate care do not end with a patient's death. When a patient dies there remains a responsibility to assist grieving family members. Unfortunately, many physicians feel ill prepared to assist in the b ... Full text Link to item Cite

Palliative care and oncology: integration leads to better care.

Journal Article Oncology (Williston Park) · November 30, 2011 The timely integration of palliative care services into standard oncology care is essential to providing comprehensive individualized care for patients with advanced and incurable cancer and their families. Herein we discuss five important areas in which t ... Link to item Cite

Palliative care and oncology: integration leads to better care.

Journal Article Oncology (Williston Park) · November 30, 2011 Link to item Cite

Longitudinal patient-reported performance status assessment in the cancer clinic is feasible and prognostic.

Journal Article J Oncol Pract · November 2011 PURPOSE: Performance status is prognostic in oncology and palliative care settings. Traditionally clinician rated, it is often inconsistently collected, recorded, and measured, thereby limiting its utility. Patient-reported strategies are increasingly used ... Full text Link to item Cite

What is the role of friends when contributing care at the end of life? Findings from an Australian population study.

Journal Article Psychooncology · February 2011 PURPOSE: To examine the role of friends as caregivers of people with terminal illness. METHOD: Piloted questions were included in the 2001-2007 random face-to-face annual health surveys of 23588 South Australians on the death of a loved one, caregiving pro ... Full text Link to item Cite

Young caregivers in the end-of-life setting: a population-based profile of an emerging group.

Journal Article J Palliat Med · October 2010 PURPOSE: Little is known about young caregivers of people with advanced life-limiting illness. Better understanding of the needs and characteristics of these young caregivers can inform development of palliative care and other support services. METHODS: A ... Full text Open Access Link to item Cite

Research in end-of-life settings: an ethical inquiry.

Journal Article J Pain Palliat Care Pharmacother · September 2010 A fundamental tension surrounds the ethics of conducting research in vulnerable populations, and specifically, research involving patients at or near the end-of-life. In Palliative Medicine, these patients' care has historically been based on compassion, c ... Full text Link to item Cite

A comparative resident site visit project: a novel approach for implementing programmatic change in the duty hours era.

Journal Article Acad Med · July 2010 The Duke University Medical Center Internal Medicine Residency Program did not reach its anticipated quota of applicants during the 2008 National Residency Matching Program. Post-Match feedback regarding workload prompted an effort to redesign the general ... Full text Link to item Cite

Acute eosinophilic pneumonia secondary to daptomycin: a report of three cases.

Journal Article Clin Infect Dis · June 1, 2010 We describe 3 cases of daptomycin-induced pulmonary toxic effects that are consistent with drug-induced acute eosinophilic pneumonia. Patients presented similarly with dyspnea, cough, hypoxia, and diffuse ground-glass opacities at chest computed tomography ... Full text Open Access Link to item Cite

Grief, interrupted.

Journal Article J Palliat Med · April 2010 Full text Open Access Link to item Cite

Developing the evidence base for palliative care: formation of the Palliative Care Research Cooperative and its first trial.

Journal Article Hosp Pract (1995) · 2010 The field of palliative care and hospice has gained accreditation, with a growing cadre of specialists being trained, but there is a dearth of robust research evidence to guide clinical practice. After 2 years of planning, a group of senior investigators c ... Full text Link to item Cite

Primary care--lifelines and shortages.

Journal Article N Engl J Med · October 1, 2009 Link to item Cite

Compassionate care at the end of life.

Journal Article Virtual Mentor · September 1, 2006 Full text Link to item Cite

CPR: Is It Always an Appropriate Option?

Journal Article Virtual Mentor · September 1, 2006 Full text Link to item Cite