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Warner Miller Burch Jr.

Warner Miller Burch Jr.

Professor Emeritus of Medicine
Medicine, Endocrinology, Metabolism, and Nutrition
warner.burch@duke.edu
Duke Box 3283, Durham, NC 27710
303 Baker House, Durham, NC 27710
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Selected Publications

Chronic myopathy due to immunoglobulin light chain amyloidosis.

Journal Article Mol Genet Metab · April 2013 Amyloid myopathy associated with a plasma cell dyscrasia is a rare cause of muscle hypertrophy. It can be a challenging diagnosis, since pathological findings are often elusive. In addition, the mechanism by which immunoglobulin light-chain deposition stim ... Full text Link to item Cite

Using bedtime (PM) and early morning (AM) urine cortisol/creatinine ratios to evaluate pituitary-adrenal function in an office practice

Journal Article Endocrine Practice · 2011 Objective: To evaluate the use of cortisol/creatinine ratios in urine specimens collected at bedtime (PM) and the following morning (AM) in a general endocrine practice as a means of assessing pituitary-adrenal function in normal volunteers, outpatients wi ... Full text Cite

Visual vignette. Hyperparathyroidism due to a parathyroid adenoma.

Journal Article Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists · 2000 Cite

Approach to the patient with Graves' disease and an anterior mediastinal mass

Journal Article Endocrinologist · 1995 A patient with hyperthyroidism and an anterior mediastinal mass presents a diagnostic challenge. The differential diagnosis warrants exclusion of a malignancy. In such cases, the CT scan helps to define the anterior mediastinal lesion. Our patient had beni ... Cite

Effect of fatty acids on insulin release: role of chain length and degree of unsaturation.

Journal Article Am J Physiol · April 1994 The purpose of the present study was to examine the role played by structural differences among fatty acids in their effect on insulin secretion by isolated perifused murine islets. Insulin secretion measured by radioimmunoassay was assessed either as tota ... Full text Link to item Cite

Addition of L-glutamine to a linoleic acid perifusate prevents the fatty acid-induced desensitization of pancreatic islet response to glucose

Journal Article The Journal of Nutritional Biochemistry · January 1, 1993 Previous studies showed that exposure of pancreatic islets to polyunsaturated fatty acids (PUFA) can render the beta cells unresponsive to glucose, thus suggesting the possibility that prolonged obligatory use of lipid preparations containing high concentr ... Full text Cite

Characterization of the insulinotropic potency of polyunsaturated fatty acids.

Journal Article Endocrinology · February 1992 In this study we have assessed the individual abilities of the essential fatty acids, linoleic and linolenic acids, to release insulin and compared their insulinotropic potencies with those of the more established nutrient insulin secretagogues, glucose an ... Full text Link to item Cite

A response to: "A woman with too much facial hair".

Journal Article North Carolina medical journal · 1992 Cite

Pancreatic hormone response to neuropeptide Y (NPY) perifusion in vitro.

Journal Article Regul Pept · July 9, 1991 Available data on the effect of neuropeptide Y (NPY) on insulin release are conflicting and little data exist regarding the effect of NPY on glucagon secretion. The purpose of the present study, therefore, was to characterize the direct effect of NPY on th ... Full text Link to item Cite

Homologous desensitization of pancreatic beta cells to glucose response by polyunsaturated fatty acids

Journal Article The Journal of Nutritional Biochemistry · January 1, 1991 We have shown recently that a mixture of 10 mM linoleic acid (18:2,ω6) and 5 mM linoleic acid (18:3,ω3) enhanced insulin secretion by microdissected islets. In the present study, our aim was to examine the effect of a prestimulus with this mixture of 10 mM ... Full text Cite

Characterization of glutamine-regulated pancreatic islet hormone release

Journal Article Surgical Forum · December 1, 1990 Cite

Enhancement of endocrine pancreatic secretions by essential fatty acids.

Journal Article J Surg Res · April 1990 Recent studies have suggested the beneficial effects of essential fatty acids in postoperative patients receiving total parenteral nutrition. While there is abundant information on the role of glucose and amino acids on insulin release, the effect of essen ... Full text Link to item Cite

The 25-kilodalton insulin-like growth factor (IGF)-binding protein inhibits both basal and IGF-I-mediated growth of chick embryo pelvic cartilage in vitro.

Journal Article J Clin Endocrinol Metab · January 1990 Insulin-like growth factor (IGF)-I stimulates the growth of many tissues, including growth plate cartilage. However, the role of IGF-binding proteins in the growth process is controversial. We purified a 25-kDa IGF-binding protein (BP-25) from amniotic flu ... Full text Link to item Cite

Insulin-like growth factor I mediates selective anabolic effects of parathyroid hormone in bone cultures

Journal Article Journal of Clinical Investigation · 1989 PTH was studied for its effects on bone formation in cultured rat calvariae. 0.01-10 nM PTH stimulated [3H]thymidine incorporation into DNA by up to 4.8-fold. Although continuous treatment with PTH for 24-72 h inhibited [3H]proline incorporation into colla ... Full text Cite

1,25-Dihydroxyvitamin D3 stimulates avian and mammalian cartilage growth in vitro.

Journal Article J Bone Miner Res · February 1988 We addressed the question of whether 1,25-dihydroxyvitamin D3 (1,25-(OH)2D) could directly stimulate cartilage growth in vitro. Pelvic leaflets from chick embryos and scapular growth plates from fetal pigs were organ cultured in serum-free medium in the pr ... Full text Link to item Cite

Heart rate control in diabetic rabbits: blunted response to isoproterenol

Journal Article American Journal of Physiology - Endocrinology and Metabolism · 1988 To study the effects of chronic diabetes on heart rate and adrenergic responsiveness we compared unanesthetized diabetic rabbits, 10-13 mo after alloxan monohydrate injection, to age-matched controls. There were no significant differences found between gro ... Cite

Gastric emptying, glucose tolerance, and insulin response after duodenojejunostomy.

Journal Article J Surg Res · May 1987 We investigated the impact of direct jejunal delivery of various meals on gastric emptying, glucose tolerance, and insulin response in a chronic dog model following duodenojejunostomy. Ten beagle dogs underwent duodenal transection 2 cm distal to the pylor ... Full text Link to item Cite

Triiodothyronine stimulates cartilage growth and maturation by different mechanisms.

Journal Article Am J Physiol · February 1987 The mechanisms by which triiodothyronine (T3) stimulates growth and maturation of growth-plate cartilage in vitro were studied by incubating embryonic chick pelvic cartilages in serum-free medium in the presence and absence of T3 for 3 days. To determine w ... Full text Link to item Cite

Chronic myopathy due to immunoglobulin light chain amyloidosis.

Journal Article Mol Genet Metab · April 2013 Amyloid myopathy associated with a plasma cell dyscrasia is a rare cause of muscle hypertrophy. It can be a challenging diagnosis, since pathological findings are often elusive. In addition, the mechanism by which immunoglobulin light-chain deposition stim ... Full text Link to item Cite

Using bedtime (PM) and early morning (AM) urine cortisol/creatinine ratios to evaluate pituitary-adrenal function in an office practice

Journal Article Endocrine Practice · 2011 Objective: To evaluate the use of cortisol/creatinine ratios in urine specimens collected at bedtime (PM) and the following morning (AM) in a general endocrine practice as a means of assessing pituitary-adrenal function in normal volunteers, outpatients wi ... Full text Cite

Visual vignette. Hyperparathyroidism due to a parathyroid adenoma.

Journal Article Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists · 2000 Cite

Approach to the patient with Graves' disease and an anterior mediastinal mass

Journal Article Endocrinologist · 1995 A patient with hyperthyroidism and an anterior mediastinal mass presents a diagnostic challenge. The differential diagnosis warrants exclusion of a malignancy. In such cases, the CT scan helps to define the anterior mediastinal lesion. Our patient had beni ... Cite

Effect of fatty acids on insulin release: role of chain length and degree of unsaturation.

Journal Article Am J Physiol · April 1994 The purpose of the present study was to examine the role played by structural differences among fatty acids in their effect on insulin secretion by isolated perifused murine islets. Insulin secretion measured by radioimmunoassay was assessed either as tota ... Full text Link to item Cite

Addition of L-glutamine to a linoleic acid perifusate prevents the fatty acid-induced desensitization of pancreatic islet response to glucose

Journal Article The Journal of Nutritional Biochemistry · January 1, 1993 Previous studies showed that exposure of pancreatic islets to polyunsaturated fatty acids (PUFA) can render the beta cells unresponsive to glucose, thus suggesting the possibility that prolonged obligatory use of lipid preparations containing high concentr ... Full text Cite

Characterization of the insulinotropic potency of polyunsaturated fatty acids.

Journal Article Endocrinology · February 1992 In this study we have assessed the individual abilities of the essential fatty acids, linoleic and linolenic acids, to release insulin and compared their insulinotropic potencies with those of the more established nutrient insulin secretagogues, glucose an ... Full text Link to item Cite

A response to: "A woman with too much facial hair".

Journal Article North Carolina medical journal · 1992 Cite

Pancreatic hormone response to neuropeptide Y (NPY) perifusion in vitro.

Journal Article Regul Pept · July 9, 1991 Available data on the effect of neuropeptide Y (NPY) on insulin release are conflicting and little data exist regarding the effect of NPY on glucagon secretion. The purpose of the present study, therefore, was to characterize the direct effect of NPY on th ... Full text Link to item Cite

Homologous desensitization of pancreatic beta cells to glucose response by polyunsaturated fatty acids

Journal Article The Journal of Nutritional Biochemistry · January 1, 1991 We have shown recently that a mixture of 10 mM linoleic acid (18:2,ω6) and 5 mM linoleic acid (18:3,ω3) enhanced insulin secretion by microdissected islets. In the present study, our aim was to examine the effect of a prestimulus with this mixture of 10 mM ... Full text Cite

Characterization of glutamine-regulated pancreatic islet hormone release

Journal Article Surgical Forum · December 1, 1990 Cite

Enhancement of endocrine pancreatic secretions by essential fatty acids.

Journal Article J Surg Res · April 1990 Recent studies have suggested the beneficial effects of essential fatty acids in postoperative patients receiving total parenteral nutrition. While there is abundant information on the role of glucose and amino acids on insulin release, the effect of essen ... Full text Link to item Cite

The 25-kilodalton insulin-like growth factor (IGF)-binding protein inhibits both basal and IGF-I-mediated growth of chick embryo pelvic cartilage in vitro.

Journal Article J Clin Endocrinol Metab · January 1990 Insulin-like growth factor (IGF)-I stimulates the growth of many tissues, including growth plate cartilage. However, the role of IGF-binding proteins in the growth process is controversial. We purified a 25-kDa IGF-binding protein (BP-25) from amniotic flu ... Full text Link to item Cite

Insulin-like growth factor I mediates selective anabolic effects of parathyroid hormone in bone cultures

Journal Article Journal of Clinical Investigation · 1989 PTH was studied for its effects on bone formation in cultured rat calvariae. 0.01-10 nM PTH stimulated [3H]thymidine incorporation into DNA by up to 4.8-fold. Although continuous treatment with PTH for 24-72 h inhibited [3H]proline incorporation into colla ... Full text Cite

1,25-Dihydroxyvitamin D3 stimulates avian and mammalian cartilage growth in vitro.

Journal Article J Bone Miner Res · February 1988 We addressed the question of whether 1,25-dihydroxyvitamin D3 (1,25-(OH)2D) could directly stimulate cartilage growth in vitro. Pelvic leaflets from chick embryos and scapular growth plates from fetal pigs were organ cultured in serum-free medium in the pr ... Full text Link to item Cite

Heart rate control in diabetic rabbits: blunted response to isoproterenol

Journal Article American Journal of Physiology - Endocrinology and Metabolism · 1988 To study the effects of chronic diabetes on heart rate and adrenergic responsiveness we compared unanesthetized diabetic rabbits, 10-13 mo after alloxan monohydrate injection, to age-matched controls. There were no significant differences found between gro ... Cite

Gastric emptying, glucose tolerance, and insulin response after duodenojejunostomy.

Journal Article J Surg Res · May 1987 We investigated the impact of direct jejunal delivery of various meals on gastric emptying, glucose tolerance, and insulin response in a chronic dog model following duodenojejunostomy. Ten beagle dogs underwent duodenal transection 2 cm distal to the pylor ... Full text Link to item Cite

Triiodothyronine stimulates cartilage growth and maturation by different mechanisms.

Journal Article Am J Physiol · February 1987 The mechanisms by which triiodothyronine (T3) stimulates growth and maturation of growth-plate cartilage in vitro were studied by incubating embryonic chick pelvic cartilages in serum-free medium in the presence and absence of T3 for 3 days. To determine w ... Full text Link to item Cite

Hashimoto's thyroiditis presenting as a retropharyngeal mass.

Journal Article North Carolina medical journal · 1987 Cite

Growth of fetal porcine scapular cartilage in vitro

Journal Article American Journal of the Medical Sciences · January 1, 1987 Fetal pig scapular cartilage provides an ideal model to study mammalian cartilage growth in vitro. Growth plate and nongrowth plate cartilages were cultured in serum-free medium for 14 days. These cartilages visibly enlarged, and their wet weight increased ... Full text Cite

Cushing's syndrome secondary to ectopic pituitary adenoma in the sphenoid sinus

Journal Article Otolaryngology-Head and Neck Surgery · January 1, 1987 Full text Cite

Malignant teratoma in the thyroid gland of an adult: a case report and a review of the literature.

Journal Article Surgery · November 1986 Teratomas in the neck are rare neoplasms. Most occur in the neonate and are benign. In contrast, cervical teratomas in adults are malignant and carry a poor prognosis. Fourteen adult cases have been reported in the world literature, and 11 of these were st ... Link to item Cite

Embryonic chick cartilage produces its own somatomedin-like peptide to stimulate cartilage growth in vitro.

Journal Article Endocrinology · September 1986 Embryonic chick pelvic cartilages increase in size and weight when incubated in a chemically defined medium in the absence of serum. We addressed the question of whether endogenous production of growth factors by the cartilage was responsible for this grow ... Full text Link to item Cite

Cushing's disease. A review.

Journal Article Arch Intern Med · June 1985 Cushing's syndrome continues to tax the most discerning clinician. I review pituitary-dependent adrenal hyperplasia (Cushing's disease), including recent experiences with Cushing's disease at Duke University, Durham, NC, and relate these observations to th ... Link to item Cite

Calcitonin stimulates maturation of mammalian growth plate cartilage.

Journal Article Endocrinology · May 1985 To determine whether calcitonin (CT) might effect maturation of mammalian growth plate cartilage, we administered salmon CT (sCT) to young rats and used the growth plate from the distal metatarsal as our in vivo growth plate model. Growth plate alkaline ph ... Full text Link to item Cite

Homologous and heterologous growth hormones fail to stimulate avian cartilage growth in vitro.

Journal Article J Clin Endocrinol Metab · April 1985 Recent reports that GH has a direct effect on growing cartilage have raised questions as to the role of somatomedins (Sm) in cartilage growth. To test the hypothesis that GH directly stimulates cartilage growth, we added homologous and heterologous GHs to ... Full text Link to item Cite

Phosphotyrosine and phosphoprotein phosphatase activity of alkaline phosphatase in mineralizing cartilage.

Journal Article Metabolism · February 1985 We used embryonic skeletal cartilage known to have high levels of alkaline phosphatase activity to determine whether growing cartilage has phosphotyrosine phosphatase activity and phosphotyrosinyl histone phosphatase activity at physiologic pH. Embryonic c ... Full text Link to item Cite

Malignant teratoma of the thyroid in an adult: CT appearance.

Journal Article J Comput Assist Tomogr · 1985 A case of malignant teratoma of the thyroid gland is presented. Computed tomography identified an inhomogeneous mass with dense calcifications involving the thyroid gland and compressing the upper airway. Enlarged, peripherally enhancing lymph nodes in the ... Full text Link to item Cite

Thyroid malignancy masquerading as thyroiditis.

Journal Article N C Med J · September 1984 Link to item Cite

Hormonal stimulation of avian embryonic cartilage growth in vitro: histologic and ultrastructural features.

Journal Article In Vitro · April 1984 We studied the histologic and ultrastructural features of embryonic chick cartilage after the cartilage had been incubated in serum-free medium that contained hormones and growth factors known to stimulate in vitro cartilage growth. Pelvic cartilages from ... Full text Link to item Cite

Calcitonin stimulates growth and maturation of embryonic chick pelvic cartilage in vitro.

Journal Article Endocrinology · April 1984 To determine whether calcitonin (CT) affects the growth of avian embryonic skeletal tissue, pelvic cartilages from 9-day-old chick embryos were incubated in a serum-free medium containing CT for 3 days. Porcine CT (PCT), salmon CT (SCT), and human CT (HCT) ... Full text Link to item Cite

Transsphenoidal microadenomectomy for Cushing's disease in children.

Journal Article New England Journal of Medicine · 1984 Cite

Ia+ T cells in new onset Graves' disease

Journal Article Journal of Clinical Endocrinology and Metabolism · 1984 The Ia (immune-associated, DR) antigen is a cell surface glycoprotein which is absent on normal circulating T lymphocytes but present on activated T lymphocytes. We studied the expression of this antigen on circulating T lymphocytes from patients with untr ... Cite

Normal menstruation and pregnancy in a patient with Nelson's syndrome.

Journal Article South Med J · October 1983 The patient with Nelson's syndrome in this report represents an unusual case in which regular cyclic menstruation was preserved even though a large ACTH-producing pituitary adenoma was present. Despite normal menses and pregnancy, the radiologic findings o ... Full text Link to item Cite

Hypoparathyroidism after I-131 therapy with subsequent return of parathyroid function.

Journal Article J Clin Endocrinol Metab · August 1983 A 22-year-old woman developed hypoparathyroidism in 1970, 10 months after treatment of hyperthyroidism with I-131. The hypocalcemia was corrected with Vitamin D2 and oral calcium and she remained normocalcemic for 8 yr. In 1979 hypercalcemia was found and ... Full text Link to item Cite

Propranolol-induced hyperthyroxinemia.

Journal Article N C Med J · April 1983 Link to item Cite

Deficient adenylate cyclase regulatory protein in renal membranes from a patient with pseudohypoparathyroidism.

Journal Article J Clin Invest · February 1983 Recent studies have established that some patients with pseudohypoparathyroidism have a deficiency of the adenylate cyclase regulatory protein (the G unit) in plasma membranes from erythrocytes, platelets, and fibroblasts. We have directly measured the act ... Full text Link to item Cite

A survey of results with transsphenoidal surgery in Cushing's disease.

Journal Article New England Journal of Medicine · 1983 Cite

Fine needle aspiration biopsy of the thyroid gland

Journal Article Annals of Internal Medicine · 1983 Cite

Triiodothyronine stimulates maturation of porcine growth-plate cartilage in vitro.

Journal Article J Clin Invest · September 1982 We studied the effect of triiodothyronine (T3) on mammalian growth-plate cartilage in vitro. Growth-plate cartilages from fetal pigs scapulae were incubated for 3 to 7 d in serum-free medium alone or medium containing T3. Alkaline phosphatase activity, a m ... Full text Link to item Cite

Triiodothyronine stimulation of in vitro growth and maturation of embryonic chick cartilage.

Journal Article Endocrinology · August 1982 We studied the direct effect of T3 on cartilage growth and maturation in vitro. Pelvic cartilages from 9-day-old chick embryos were incubated in a serum-free organ culture system which supported cartilage growth over a 5-day interval. The addition of T3 (1 ... Full text Link to item Cite

In vitro stimulation of alkaline phosphatase activity in immature embryonic chick pelvic cartilage by adenosine 3'5'-monophosphate.

Journal Article J Cell Biol · May 1982 Cyclic AMP content in embryonic chick pelvic cartilage increases significantly as the embryo ages from 8 to 10 d. This in ovo elevation in cyclic AMP content precedes maximal cartilage alkaline phosphatase activity by some 24 h. We studied whether this tem ... Full text Link to item Cite

Urine free-cortisol determination. A useful tool in the management of chronic hypoadrenal states.

Journal Article JAMA · April 9, 1982 The clinical value of urine free-cortisol (UFC) determination in the management of hypoadrenal states in patients receiving maintenance glucocorticoid therapy was assessed. Nine patients with primary adrenal insufficiency collected five 24-hour urine speci ... Full text Link to item Cite

Induction of cellular immunity to Coccidioides immitis after sensitization with dinitrochlorobenzene.

Journal Article Ann Intern Med · March 1982 A patient had progressive disseminated coccidioidomycosis and depressed cellular immunity to Coccidioides immitis. He developed a large nasal coccidioidal lesion that was unresponsive to conventional therapy. Application of dinitrochlorobenzene (DNCB) to t ... Full text Link to item Cite

In vitro stimulation of mammalian cartilage maturation by triiodothyronine

Journal Article Clinical Research · January 1, 1982 Cite

Parathyroid hormone stimulates embryonic cartilage growth

Journal Article Clinical Research · January 1, 1982 Cite

Hormonal activation of ornithine decarboxylase in embryonic chick pelvic cartilage.

Journal Article Am J Physiol · December 1981 We assessed whether hormones and metabolic factors known to stimulate anabolic processes in the embryonic chick pelvic cartilage would stimulate ornithine decarboxylase (ODC) activity. In vitro organ culture of these pelvic cartilages in time-course experi ... Full text Link to item Cite

Adenosine 3',5'-monophosphate: a modulator of embryonic chick cartilage growth.

Journal Article J Clin Invest · December 1981 We tested the hypothesis that cyclic AMP plays a significant role in modulating the growth of embryonic chick cartilage by determining whether cyclic AMP levels change in growing embryonic cartilage and whether cyclic AMP could stimulate embryonic cartilag ... Full text Link to item Cite

Hormonal activation of ornithine decarboxylase in embryonic chick pelvic cartilage

Journal Article American Journal of Physiology - Endocrinology and Metabolism · December 1, 1981 We assessed whether hormones and metabolic factors known to stimulate anabolic processes in the embryonic chick pelvic cartilage would stimulate ornithine decarboxylase (ODC) activity. In vitro organ culture of these pelvic cartilages in time-course experi ... Cite

Thyroid nodules: 1981.

Journal Article North Carolina medical journal · 1981 Cite

Parathyroid hormone stimulates embryonic cartilage growth

Journal Article Clinical Research · January 1, 1981 Cite

Specific nuclear binding of adenosine 3',5'-monophosphate-binding protein complex with subsequent poly(A) RNA synthesis in embryonic chick cartilage.

Journal Article J Clin Invest · September 1980 We used embryonic chick pelvic cartilage as a model to study the mechanism by which cyclic AMP increases RNA synthesis. Isolated nuclei were incubated with [32P]-8-azidoadenosine 3,5'-monophosphate ([32P]N3cAMP) with no resultant specific nuclear binding. ... Full text Link to item Cite

Pseudothyrotoxic myopathy: a complication of thionamide therapy in hyperthyroidism.

Journal Article South Med J · November 1979 A hyperthyroid patient treated with methimazole for three weeks developed proximal muscle weakness, myalgia, arthralgia, and fever, and thyrotoxic myopathy was diagnosed. The signs and symptoms spontaneously abated when antithyroid medication was discontin ... Link to item Cite

A method of aspirating thyroid cysts.

Journal Article Surg Gynecol Obstet · January 1979 This method is safe, efficient and dependable. Important points in the method are positioning of the patient and operator, localizing the cyst with one hand and controlling the needle with the other and aspirating material by way of a connection tube to a ... Link to item Cite

Altered activity of the nucleotide regulatory site in the parathyroid hormone-sensitive adenylate cyclase from the renal cortex of a patient with pseudohypoparathyroidism.

Journal Article J Clin Invest · December 1978 A series of clinical studies suggest that the primary defect underlying pseudohypoparathyroidism is an abnormality of the parathyroid hormone-receptor-adenylate cyclase complex of the renal cortical cell plasma membrane. In the present study we compared pa ... Full text Link to item Cite

Mechanism of thyroid allograft rejection

Journal Article Australian Journal of Experimental Biology and Medical Science · 1976 Balb/c thyroids, held in organ culture for 26 days, survive and function as well as isografts for > 100 days in CBA recipients. Uncultured allografts are totally rejected by 20 days after transplantation. Prolonged allograft survival can also be achieve ... Cite