Scholars@Duke
Zheng Chang

Zheng Chang

Professor of Radiation Oncology
Radiation Oncology

Selected Publications

Multi-parametric MRI (mpMRI) for treatment response assessment of radiation therapy.

Journal Article Med Phys · April 2022 Magnetic resonance imaging (MRI) plays an important role in the modern radiation therapy (RT) workflow. In comparison with computed tomography (CT) imaging, which is the dominant imaging modality in RT, MRI possesses excellent soft-tissue contrast for radi ... Full text Link to item Cite

Establishing ADC-Based Histogram and Texture Features for Early Treatment-Induced Changes in Head and Neck Squamous Cell Carcinoma.

Journal Article Front Oncol · 2021 The purpose of this study was to assess baseline variability in histogram and texture features derived from apparent diffusion coefficient (ADC) maps from diffusion-weighted MRI (DW-MRI) examinations and to identify early treatment-induced changes to these ... Full text Link to item Cite

Multimaterial three-dimensional printing in brachytherapy: Prototyping teaching tools for interstitial and intracavitary procedures in cervical cancers.

Journal Article Brachytherapy · 2020 PURPOSE: As the utilization of brachytherapy procedures continues to decline in clinics, a need for accessible training tools is required to help bridge the gap between resident comfort in brachytherapy training and clinical practice. To improve the qualit ... Full text Link to item Cite

Remaining Useful Lifetime Prediction for the Equipment with the Random Failure Threshold

Conference 2019 Prognostics and System Health Management Conference Phm Qingdao 2019 · October 1, 2019 Prognostics and health management (PHM) technology is widely used in industrial production, and its core is to predict the remaining useful life (RUL) of the equipment. For the existing research of RUL prediction, the impact of random failure threshold (RF ... Full text Cite

Equipment Maintenance Decision Model Based on Degradation Data and Failure Data

Conference Proceedings of 2019 International Conference on Quality Reliability Risk Maintenance and Safety Engineering Qr2mse 2019 · August 1, 2019 The degradation of data and failure data is used to make the maintenance decision of equipment in this paper. Firstly, the Wiener process is used to build the degradation model which is according to the degradation data of the equipment. Then, the random d ... Full text Cite

Computer vision analysis captures atypical attention in toddlers with autism.

Journal Article Autism · April 2019 To demonstrate the capability of computer vision analysis to detect atypical orienting and attention behaviors in toddlers with autism spectrum disorder. One hundered and four toddlers of 16-31 months old (mean = 22) participated in this study. Twenty-two ... Full text Link to item Cite

A Spatiotemporal-Constrained Sorting Method for Motion-Robust 4D-MRI: A Feasibility Study.

Journal Article Int J Radiat Oncol Biol Phys · March 1, 2019 PURPOSE: To develop a spatiotemporal-constrained sorting technique for motion-robust 4 dimensional-magnetic resonance imaging. METHODS AND MATERIALS: This sorting method implemented 2 new approaches for 4-dimensional imaging: (1) an optimized sparse k-spac ... Full text Link to item Cite

An investigation of machine learning methods in delta-radiomics feature analysis.

Journal Article PLoS One · 2019 PURPOSE: This study aimed to investigate the effectiveness of using delta-radiomics to predict overall survival (OS) for patients with recurrent malignant gliomas treated by concurrent stereotactic radiosurgery and bevacizumab, and to investigate the effec ... Full text Open Access Link to item Cite

Effectiveness evaluation method of system-of-systems based on operation loop and improved information entropy

Journal Article Xi Tong Gong Cheng Yu Dian Zi Ji Shu Systems Engineering and Electronics · January 1, 2019 Aiming at the problem of various equipment and complicated correlations in operation system-of-systems under the information conditions, an effectiveness evaluation method of system-of-systems based on the operation loop and improved information entropy is ... Full text Cite

Evaluation of Equipment Contribution Rate to System-of-systems Based on Hybrid Parameter Evidential Network

Journal Article Binggong Xuebao Acta Armamentarii · December 1, 2018 An evaluation method of equipment contribution rate to system-of-systems based on hybrid parameter evidential network is proposed for the complicated correlation between the capability of equipment system-of-systems and the uncertainty of evaluating inform ... Full text Cite

Assessment of concurrent stereotactic radiosurgery and bevacizumab treatment of recurrent malignant gliomas using multi-modality MRI imaging and radiomics analysis.

Journal Article J Radiosurg SBRT · 2018 PURPOSE: To assess the response and predict the overall survival (OS) of recurrent malignant gliomas (MG) patients treated with concurrent BVZ/SRS using multi-modality MRI imaging and radiomics analysis.Methods and materials: SRS was delivered in a single ... Link to item Cite

Real-time dose-rate monitoring with gynecologic brachytherapy: Results of an initial clinical trial.

Journal Article Brachytherapy · 2018 PURPOSE: A nanoscintillator-based fiber-optic dosimeter (nanoFOD) was developed to measure real-time dose rate during high-dose-rate (HDR) brachytherapy. A trial was designed to prospectively test clinical feasibility in gynecologic implants. METHODS AND M ... Full text Link to item Cite

Development of a Computerized 4-D MRI Phantom for Liver Motion Study.

Journal Article Technol Cancer Res Treat · December 2017 PURPOSE: To develop a 4-dimensional computerized magnetic resonance imaging phantom with image textures extracted from real patient scans for liver motion studies. METHODS: The proposed phantom was developed based on the current version of 4-dimensional ex ... Full text Link to item Cite

Advances in imaging simulation for lung cancer IGRT

Chapter · September 18, 2017 This chapter focuses on advances in computed tomography (CT), magnetic resonance imaging (MRI), positron emission tomography (PET), and other imaging methods in lung cancer applications, and discuss their potentials and limitations for use in clinical prac ... Cite

Accelerated Brain DCE-MRI Using Iterative Reconstruction With Total Generalized Variation Penalty for Quantitative Pharmacokinetic Analysis: A Feasibility Study.

Journal Article Technol Cancer Res Treat · August 2017 PURPOSE: To investigate the feasibility of using undersampled k-space data and an iterative image reconstruction method with total generalized variation penalty in the quantitative pharmacokinetic analysis for clinical brain dynamic contrast-enhanced magne ... Full text Link to item Cite

Nanosecond pulse signals restoration via stochastic resonance in the Fabry-Perot cavity with graphene

Journal Article EPJ Applied Physics · August 1, 2017 We investigate a technology for reconstructing nanosecond pulse noise hidden signals via stochastic resonance, which is based on optical bistability in the Fabry-Perot (F-P) cavity with graphene. The bistable properties are analyzed with different initial ... Full text Cite

Assessment of Treatment Response With Diffusion-Weighted MRI and Dynamic Contrast-Enhanced MRI in Patients With Early-Stage Breast Cancer Treated With Single-Dose Preoperative Radiotherapy: Initial Results.

Journal Article Technol Cancer Res Treat · October 2016 Single-dose preoperative stereotactic body radiotherapy is a novel radiotherapy technique for the early-stage breast cancer, and the treatment response pattern of this technique needs to be investigated on a quantitative basis. In this work, dynamic contra ... Full text Link to item Cite

Ultrafast Volumetric Cine Magnetic Resonance Imaging (UVC-MRI) for Real-Time 3-Dimensional Target Localization/Tracking

Conference INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS · October 1, 2016 Link to item Cite

Evaluation of the effect of transcytolemmal water exchange analysis for therapeutic response assessment using DCE-MRI: a comparison study.

Journal Article Phys Med Biol · July 7, 2016 This study compares the shutter-speed (SS) and the Tofts models as used in assessing therapeutic response in a longitudinal DCE-MRI experiment. Sixteen nu/nu mice with implanted colorectal adenocarcinoma cell line (LS-174T) were randomly assigned into trea ... Full text Link to item Cite

A Technique for Generating Volumetric Cine-Magnetic Resonance Imaging.

Journal Article Int J Radiat Oncol Biol Phys · June 1, 2016 PURPOSE: The purpose of this study was to develop a techique to generate on-board volumetric cine-magnetic resonance imaging (VC-MRI) using patient prior images, motion modeling, and on-board 2-dimensional cine MRI. METHODS AND MATERIALS: One phase of a 4- ... Full text Link to item Cite

Real Time Dosimetry for Gynecologic Brachytherapy: Initial Results of a Prospective Clinical Trial (vol 93, pg S203, 2015)

Journal Article INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS · June 1, 2016 Link to item Cite

SU-G-201-13: Investigation of Dose Variation Induced by HDR Ir-192 Source Global Shift Within the Varian Ring Applicator Using Monte Carlo Methods.

Journal Article Med Phys · June 2016 PURPOSE: The Varian tandem and ring applicators are used to deliver HDR Ir-192 brachytherapy for cervical cancer. The source path within the ring is hard to predict due to the larger interior ring lumen. Some studies showed the source could be several mill ... Full text Link to item Cite

TH-EF-BRA-08: A Novel Technique for Estimating Volumetric Cine MRI (VC-MRI) From Multi-Slice Sparsely Sampled Cine Images Using Motion Modeling and Free Form Deformation.

Conference Med Phys · June 2016 PURPOSE: To develop a technique to estimate on-board VC-MRI using multi-slice sparsely-sampled cine images, patient prior 4D-MRI, motion-modeling and free-form deformation for real-time 3D target verification of lung radiotherapy. METHODS: A previous metho ... Full text Link to item Cite

TU-AB-BRA-09: A Novel Method of Generating Ultrafast Volumetric Cine MRI (VC-MRI) Using Prior 4D-MRI and On-Board Phase-Skipped Encoding Acquisition for Radiotherapy Target Localization.

Conference Med Phys · June 2016 PURPOSE: To develop a technique generating ultrafast on-board VC-MRI using prior 4D-MRI and on-board phase-skipped encoding k-space acquisition for real-time 3D target tracking of liver and lung radiotherapy. METHODS: The end-of-expiration (EOE) volume in ... Full text Link to item Cite

TU-AB-202-04: Development of a DeformableImage Registration (DIR) Error Correction Method Employing Kolmogorov-Zurbenko(KZ) Filter.

Journal Article Med Phys · June 2016 PURPOSE: This study aims to develop a DIR error correction method capable of utilizing sparse ground-truth motion information and recovering missing data with the Kolmogorov-Zurbenko (KZ) filter. METHODS: The error correction method employs a two-step appr ... Full text Link to item Cite

MO-B-BRC-02: Ultrasound Based Prostate HDR.

Journal Article Med Phys · June 2016 Brachytherapy has proven to be an effective treatment option for prostate cancer. Initially, prostate brachytherapy was delivered through permanently implanted low dose rate (LDR) radioactive sources; however, high dose rate (HDR) temporary brachytherapy f ... Full text Link to item Cite

SU-F-R-32: Evaluation of MRI Acquisition Parameter Variations On Texture Feature Extraction Using ACR Phantom.

Journal Article Med Phys · June 2016 PURPOSE: To investigate the sensitivity of classic texture features to variations of MRI acquisition parameters. METHODS: This study was performed on American College of Radiology (ACR) MRI Accreditation Program Phantom. MR imaging was acquired on a GE 750 ... Full text Link to item Cite

SU-F-J-155: Evaluation of Transcytolemmal Water Exchange Analysis For Therapeutic Response Assessment Using Dynamic Contrast-Enhanced MRI.

Journal Article Med Phys · June 2016 PURPOSE: To compare the performance of shutter-speed(SS) model with transcytolemmal water exchange analysis against the Tofts model in the study of the efficacy of an anti-angiogenesis drug METHODS: 16 mice with LS-174T implanted were randomly assigned int ... Full text Link to item Cite

SU-F-R-15: Establishing Relevant ADC-Based Texture Analysis Metrics for Quantifying Early Treatment-Induced Changes in Head and Neck Squamous Cell Carcinoma.

Journal Article Med Phys · June 2016 PURPOSE: The purpose of this study is to identify texture analysis metrics from apparent diffusion coefficient (ADC) maps that would provide quantifiable changes with treatment in patients with head and neck squamous cell carcinoma (HNSCC). We discerned wh ... Full text Link to item Cite

Dynamic fractal signature dissimilarity analysis for therapeutic response assessment using dynamic contrast-enhanced MRI.

Journal Article Med Phys · March 2016 PURPOSE: To develop a dynamic fractal signature dissimilarity (FSD) method as a novel image texture analysis technique for the quantification of tumor heterogeneity information for better therapeutic response assessment with dynamic contrast-enhanced (DCE) ... Full text Link to item Cite

An efficient calculation method for pharmacokinetic parameters in brain permeability study using dynamic contrast-enhanced MRI.

Journal Article Magn Reson Med · February 2016 PURPOSE: To develop an efficient method for calculating pharmacokinetic (PK) parameters in brain DCE-MRI permeability studies. METHODS: A linear least-squares fitting algorithm based on a derivative expression of the two-compartment PK model was proposed t ... Full text Link to item Cite

Physics considerations for single-isocenter, volumetric modulated arc radiosurgery for treatment of multiple intracranial targets.

Conference Pract Radiat Oncol · 2016 OBJECTIVE: Our purpose was to address challenges associated with single-isocenter radiosurgery for multiple intracranial targets (SIRMIT) including increased sensitivity to rotational uncertainties (resulting from distance of the targets from isocenter) as ... Full text Link to item Cite

Susceptibility-based positive contrast MRI of brachytherapy seeds.

Journal Article Magn Reson Med · September 2015 PURPOSE: To provide visualization of the brachytherapy seeds and differentiation with natural structures in MRI by taking advantage of their high magnetic susceptibility to generate positive-contrast images. METHODS: The method is based on mapping the susc ... Full text Link to item Cite

Preoperative Single-Fraction Partial Breast Radiation Therapy: A Novel Phase 1, Dose-Escalation Protocol With Radiation Response Biomarkers.

Journal Article Int J Radiat Oncol Biol Phys · July 15, 2015 PURPOSE: Women with biologically favorable early-stage breast cancer are increasingly treated with accelerated partial breast radiation (PBI). However, treatment-related morbidities have been linked to the large postoperative treatment volumes required for ... Full text Link to item Cite

SU-E-J-223: A BOLD Contrast Imaging Sequence to Evaluate Oxygenation Changes Due to Breath Holding for Breast Radiotherapy: A Pilot Study.

Journal Article Med Phys · June 2015 PURPOSE: To develop a robust MRI sequence to measure BOLD breath hold induced contrast in context of breast radiotherapy. METHODS: Two sequences were selected from prior studies as candidates to measure BOLD contrast attributable to breath holding within t ... Full text Link to item Cite

TH-CD-204-07: Evaluation of Dynamic Fractal Signature Dissimilarity as a Novel Biomarker in Therapeutic Response Assessment Using Dynamic Contrast-Enhanced MRI.

Journal Article Med Phys · June 2015 PURPOSE: To evaluate dynamic fractal signature dissimilarity (FSD) analysis in the therapeutic response assessment using longitudinal DCE-MRI. METHODS: A novel texture analysis method of dynamic FSD was proposed to quantify the heterogeneity of contrast ag ... Full text Link to item Cite

MO-FG-210-01: Commissioning An US System for Brachytherapy: An Overview of Physics, Instrumentation, and Techniques.

Journal Article Med Phys · June 2015 UNLABELLED: Ultrasound (US) is one of the most widely used imaging modalities in medical practice. Since US imaging offers real-time imaging capability, it has becomes an excellent option to provide image guidance for brachytherapy (IGBT). (1) The physics ... Full text Link to item Cite

TU-F-CAMPUS-J-02: Evaluation of Textural Feature Extraction for Radiotherapy Response Assessment of Early Stage Breast Cancer Patients Using Diffusion Weighted MRI and Dynamic Contrast Enhanced MRI.

Journal Article Med Phys · June 2015 PURPOSE: To investigate the feasibility of using classic textural feature extraction in radiotherapy response assessment, we studied a unique cohort of early stage breast cancer patients with paired pre - and post-radiation Diffusion Weighted MRI (DWI-MRI) ... Full text Link to item Cite

SU-E-T-613: Physics Considerations for Single-Isocenter Volumetric Modulated Arc Radiosurgery for Treatment of Multiple Intracranial Targets.

Journal Article Med Phys · June 2015 PURPOSE: To address physics challenges associated with single isocenter radiosurgery for multiple intracranial metastases (SIRMIT). Because the Varian High Definition MLC has thicker leaves >4cm from the isocenter, we predict inferior dose falloff and plan ... Full text Link to item Cite

SU-D-BRA-01: Therapeutic Response Assessment Using a Novel Gray Level Local Power Matrix (GLLPM) in DCE-MRI Texture Analysis: Feasibility Study.

Journal Article Med Phys · June 2015 PURPOSE: Most current DCE-MRI texture analysis methods focus on the spatial information of chosen contrast-enhanced MR volumes or pharmacokinetic (PK) parameter maps, and the temporal information is not well included. This work proposed a novel texture mat ... Full text Link to item Cite

Treatment assessment of radiotherapy using MR functional quantitative imaging.

Journal Article World J Radiol · January 28, 2015 Recent developments in magnetic resonance (MR) functional quantitative imaging have made it a potentially powerful tool to assess treatment response in radiation therapy. With its abilities to capture functional information on underlying tissue characteris ... Full text Link to item Cite

Defining the optimal planning target volume in image-guided stereotactic radiosurgery of brain metastases: results of a randomized trial.

Journal Article Int J Radiat Oncol Biol Phys · January 1, 2015 PURPOSE: To identify an optimal margin about the gross target volume (GTV) for stereotactic radiosurgery (SRS) of brain metastases, minimizing toxicity and local recurrence. METHODS AND MATERIALS: Adult patients with 1 to 3 brain metastases less than 4 cm ... Full text Link to item Cite

A phase 1 trial of preoperative partial breast radiation therapy: Patient selection, target delineation, and dose delivery.

Journal Article Pract Radiat Oncol · 2015 PURPOSE: Diffusion of accelerated partial breast irradiation into clinical practice is limited by the need for specialized equipment and training. The accessible external beam technique yields unacceptable complication rates, likely from large postoperativ ... Full text Link to item Cite

Low-cost Gaze and Pulse Analysis using RealSense

Conference Proceedings of the 5th EAI International Conference on Wireless Mobile Communication and Healthcare · 2015 Cite

Is diaphragm motion a good surrogate for liver tumor motion?

Journal Article Int J Radiat Oncol Biol Phys · November 15, 2014 PURPOSE: To evaluate the relationship between liver tumor motion and diaphragm motion. METHODS AND MATERIALS: Fourteen patients with hepatocellular carcinoma (10 of 14) or liver metastases (4 of 14) undergoing radiation therapy were included in this study. ... Full text Link to item Cite

Investigation of sagittal image acquisition for 4D-MRI with body area as respiratory surrogate.

Journal Article Med Phys · October 2014 PURPOSE: The authors have recently developed a novel 4D-MRI technique for imaging organ respiratory motion employing cine acquisition in the axial plane and using body area (BA) as a respiratory surrogate. A potential disadvantage associated with axial ima ... Full text Link to item Cite

Preoperative Partial Breast Radiation Therapy: One Year Outcomes and Radiation-Induced Changes in Gene Expression

Conference International Journal of Radiation Oncology*Biology*Physics · September 2014 Full text Cite

Early Stage Breast Cancer Radiation Treatment Assessment Using Diffusion Weighted MRI and Dynamic Contrast Enhanced MRI

Conference International Journal of Radiation Oncology*Biology*Physics · September 2014 Full text Cite

Review of treatment assessment using DCE-MRI in breast cancer radiation therapy.

Journal Article World J Methodol · June 26, 2014 As a noninvasive functional imaging technique, dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is being used in oncology to measure properties of tumor microvascular structure and permeability. Studies have shown that parameters derived from ... Full text Link to item Cite

MO-G-18C-04: Improved Synthetic 4D-MRI Using Linear Polynomial Fitting Model.

Journal Article Med Phys · June 2014 PURPOSE: To reduce deformable image registration error by fitting the displacement vector field (DVF) to smooth the motion trajectory of each pixel in synthetic 4D-MRI. METHODS: Five patients with cancers in the liver were enrolled in this study. For a 4D ... Full text Link to item Cite

TU-D-BRD-01: Image Guided SBRT II: Challenges ' Pitfalls.

Journal Article Med Phys · June 2014 Stereotactic body radiation therapy (SBRT) has been effective treatment for the management of various diseases, which often delivers high radiation dose in a single or a few fractions. SBRT therefore demands precise treatment delivery to the tumor while sp ... Full text Link to item Cite

SU-E-J-182: A Feasibility Study Evaluating Automatic Identification of Gross Tumor Volume for Breast Cancer Radiotherapy Using Dynamic Contrast-Enhanced MR Imaging.

Journal Article Med Phys · June 2014 PURPOSE: To develop a computerized pharmacokinetic model-free Gross Tumor Volume (GTV) segmentation method based on dynamic contrastenhanced MRI (DCE-MRI) data that can improve physician GTV contouring efficiency. METHODS: 12 patients with biopsy-proven ea ... Full text Link to item Cite

Four-dimensional magnetic resonance imaging using axial body area as respiratory surrogate: initial patient results.

Journal Article Int J Radiat Oncol Biol Phys · March 15, 2014 PURPOSE: To evaluate the feasibility of a retrospective binning technique for 4-dimensional magnetic resonance imaging (4D-MRI) using body area (BA) as a respiratory surrogate. METHODS AND MATERIALS: Seven patients with hepatocellular carcinoma (4 of 7) or ... Full text Link to item Cite

Evaluating radiation-induced white matter changes in patients treated with stereotactic radiosurgery using diffusion tensor imaging: a pilot study.

Journal Article Technol Cancer Res Treat · February 2014 Featured Publication Stereotactic radiosurgery (SRS) has been an effective treatment method for brain tumors; however, few data are available regarding radiation-induced white matter (WM) damage by SRS. In this work, diffusion tensor imaging (DTI) was used to investigate WM ch ... Full text Link to item Cite

Dosimetric comparison of 3D conformal, IMRT, and V-MAT techniques for accelerated partial-breast irradiation (APBI).

Journal Article Med Dosim · 2014 The purpose is to dosimetrically compare the following 3 delivery techniques: 3-dimensional conformal radiation therapy (3D-CRT), intensity-modulated arc therapy (IMRT), and volumetric-modulated arc therapy (V-MAT) in the treatment of accelerated partial-b ... Full text Link to item Cite

Imaging and localizing interventional devices by susceptibility mapping using MRI.

Conference Annu Int Conf IEEE Eng Med Biol Soc · 2014 MRI has been used for imaging interventional procedures with devices such as brachytherapy seeds, biopsy needles, markers, and stents. However, the high susceptibility of these devices leads to signal loss and distortion in the MRI images. Previously, we p ... Full text Link to item Cite

Stereotactic ablative body radiotherapy (SABR) for effective palliation of metastases: factors affecting local control.

Journal Article J Radiosurg SBRT · 2014 We analyzed factors associated with inferior local control following stereotactic ablative body radiotherapy (SABR) for palliation of metastases. We reviewed records of patients receiving SABR for metastases at Duke University from 2006-2010. Biologically ... Link to item Cite

Quintuple-modality (SERS-MRI-CT-TPL-PTT) plasmonic nanoprobe for theranostics.

Journal Article Nanoscale · December 21, 2013 A unique quintuple-modality theranostic nanoprobe (QMT) is developed with gold nanostars for surface-enhanced Raman scattering (SERS), magnetic resonance imaging (MRI), computed tomography (CT), two-photon luminescence (TPL) imaging and photothermal therap ... Full text Link to item Cite

Abstract P5-14-04: Preoperative single-fraction partial breast radiotherapy – Initial results from a novel phase I dose-escalation protocol with exploration of radiation response biomarkers

Conference Cancer Research · December 15, 2013 AbstractPurpose/Objectives(s): Women with biologically favorable early stage breast cancer are increasingly treated with accelerated partial breast techniques. However, many alternative techniques require co ... Full text Cite

4D-MRI Using Sagittal Acquisition and Body Area as Respiratory Surrogate

Conference International Journal of Radiation Oncology*Biology*Physics · October 2013 Full text Cite

Concurrent stereotactic radiosurgery and bevacizumab in recurrent malignant gliomas: a prospective trial.

Journal Article Int J Radiat Oncol Biol Phys · August 1, 2013 PURPOSE: Virtually all patients with malignant glioma (MG) eventually recur. This study evaluates the safety of concurrent stereotactic radiosurgery (SRS) and bevacizumab (BVZ), an antiangiogenic agent, in treatment of recurrent MG. METHODS AND MATERIALS: ... Full text Link to item Cite

SU-E-T-143: Dosimetric Characteristics of TrueBeam STx System with High Definition Multi-Leaf Collimator: Commissioning of Stereotactic Radiosurgery.

Journal Article Med Phys · June 2013 IntroductionDosimetric characteristics of one TrueBeam STx treatment unit with a 120-leaf high definition multileaf collimator (HD120MLC) are systematically measured for commissioning of stereotactic radiosurgery (SRS). Due to limited data available, it is ... Full text Link to item Cite

TU-G-134-01: 4D-MRI Using Body Area as Internal Respiratory Surrogate: Initial Patient Results.

Journal Article Med Phys · June 2013 PURPOSE: We have previously developed a novel 4D-MRI technique using body area (BA) as internal respiratory surrogate. This study is to demonstrate our initial patient results via validating the accuracy of tumor motion measurements and the improvement of ... Full text Link to item Cite

TH-C-141-07: T2-Weighted 4D-MRI with Combined Phase and Amplitude Sorting.

Journal Article Med Phys · June 2013 PURPOSE: T2-weighted MR provides excellent delineation of malignant liver lesions due to its superior tumor-to-tissue contrast. This study aims to develop a novel T2-weighted retrospective 4D-MRI technique for imaging organ/tumor respiratory motion with im ... Full text Link to item Cite

WE-C-116-07: Tumor Enhancement Using Deformable Image Registration for Four-Dimensional Magnetic Resonance Imaging (4D-MRI): A Feasibility Study.

Journal Article Med Phys · June 2013 PURPOSE: We have previously developed a 4D-MRI technique using the fast imaging sequence employing steady-state acquisition (FIESTA) sequence, which has suboptimal tumor-to-tissue contrast-to-noise ratio (CNR) due to its T2*/T1 weighting. This study invest ... Full text Link to item Cite

SU-E-T-560: A Method to Determine Optimal Dynamic MLC Parameters for Varian Truebeam with Millennium MLC and HDMLC.

Conference Med Phys · June 2013 PURPOSE: Correct MLC modeling is essential to the accurate IMRT delivery. Most TPSs use simplified models with parameters of leaf transmission (LT) and dynamic leaf gap (DLG). The common way to determine them is through extrapolation from measurements. In ... Full text Link to item Cite

Investigation of sliced body volume (SBV) as respiratory surrogate.

Journal Article J Appl Clin Med Phys · January 7, 2013 The purpose of this study was to evaluate the sliced body volume (SBV) as a respiratory surrogate by comparing with the real-time position management (RPM) in phantom and patient cases. Using the SBV surrogate, breathing signals were extracted from unsorte ... Full text Open Access Link to item Cite

SU‐E‐J‐150: Investigation of Feasibility of Concurrent Orthogonal KV and MV X‐Ray Imaging for Tagrget Tracking During Dose Delivery for Stereotactic Body Radiotherapy (SBRT): A Pilot Phantom Study

Conference Medical Physics · January 1, 2013 Purpose: To investigate feasibility of motion tracking using concurrent orthogonal kV and MV x‐ray images acquired during dose delivery for stereotactic body radiotherapy (SBRT).Method and Materials: The study was performed on a Varian TrueBeam treatment u ... Full text Cite

SU‐E‐CAMPUS‐J‐04: Evaluating Radiation‐Induced Changes with Diffusion Weighted MRI and Dynamic Contrast Enhanced MRI in Patients with Early Stage Breast Cancer Treated with Stereotactic Body Radiotherapy: Initial Results

Conference Medical Physics · January 1, 2013 Purpose: Pre‐operative stereotactic body radiosurgery (SBRT) was delivered in a single fraction to treat patients with early stage breast cancer; however, few data are available regarding radiation‐induced changes by SBRT. In this work, diffusion weighted ... Full text Cite

Investigation of sliced body volume (SBV) as respiratory surrogate

Journal Article Journal of Applied Clinical Medical Physics · January 1, 2013 The purpose of this study was to evaluate the sliced body volume (SBV) as a respiratory surrogate by comparing with the real-time position management (RPM) in phantom and patient cases. Using the SBV surrogate, breathing signals were extracted from unsorte ... Full text Cite

Localization of brachytherapy seeds in MRI by deconvolution.

Journal Article Annu Int Conf IEEE Eng Med Biol Soc · 2013 MRI has the potential to be used as a preferred imaging method for brachytherapy during the seed insertion and post-surgery evaluation. However, the brachytherapy seeds usually appear dark in the MRI magnitude images. Previously, we have developed a method ... Full text Link to item Cite

Commissioning and dosimetric characteristics of TrueBeam system: composite data of three TrueBeam machines.

Journal Article Med Phys · November 2012 Featured Publication PURPOSE: A TrueBeam linear accelerator (TB-LINAC) is designed to deliver traditionally flattened and flattening-filter-free (FFF) beams. Although it has been widely adopted in many clinics for patient treatment, limited information is available related to ... Full text Link to item Cite

Imaging system QA of a medical accelerator, Novalis Tx, for IGRT per TG 142: our 1 year experience.

Journal Article J Appl Clin Med Phys · July 5, 2012 Featured Publication American Association of Physicists in Medicine (AAPM) task group (TG) 142 has recently published a report to update recommendations of the AAPM TG 40 report and add new recommendations concerning medical accelerators in the era of image-guided radiation th ... Full text Open Access Link to item Cite

SU-D-218-02: 4D-MRI Based on Body Area (BA) Surrogate and Sagittal Image Acquisition.

Journal Article Med Phys · June 2012 PURPOSE: 4D-MRI based on body area (BA) surrogate using axial image acquisition has been demonstrated. Since respiratory motion mostly occurs in the superior-inferior (SI) direction, it is expected that sagittal acquisition may provide more robust and accu ... Full text Link to item Cite

WE-E-BRA-01: Introduction to Treatment Assessment of Radiation Therapy Using MR Functional Imaging and Its Application to Intracranial Stereotactic Radiosurgery.

Journal Article Med Phys · June 2012 UNLABELLED: Recent developments in MRI have substantially improved its performance, making it a potentially powerful tool for not only diagnosis but also therapy. Treatment assessment using MR functional imaging is the process of using MR functional imagin ... Full text Link to item Cite

SU-E-J-32: Evaluation of the Dosimetric Accuracy of Stereotactic Radiosurgery with Cone-Beam Computed Tomography Localization.

Journal Article Med Phys · June 2012 PURPOSE: To evaluate the dosimetric accuracy of stereotactic radiosurgery (SRS) with cone-beam computed tomography (CBCT) guided patient localization. METHODS: A Novalis TX linear accelerator with high definition multileaf collimator (HDMLC) was used for S ... Full text Link to item Cite

SU-E-T-104: Commissioning and Dosimetric Characteristics of TrueBeam System: Composite Data of Three TrueBeam Machines.

Journal Article Med Phys · June 2012 INTRODUCTION: A TrueBeam linear accelerator (TB-LINAC) is designed to deliver standard flattened and flattening-filter-free (FFF) beams. In our institute, three TB-LINAC units are installed. In this work, composite data of the three units and multi-unit co ... Full text Link to item Cite

Stereotactic radiotherapy for malignancies involving the trigeminal and facial nerves.

Journal Article Technol Cancer Res Treat · June 2012 Featured Publication Involvement of a cranial nerve caries a poor prognosis for many malignancies. Recurrent or residual disease in the trigeminal or facial nerve after primary therapy poses a challenge due to the location of the nerve in the skull base, the proximity to the b ... Full text Link to item Cite

Accelerating phase contrast MR angiography by simplified skipped phase encoding and edge deghosting with array coil enhancement.

Journal Article Med Phys · March 2012 Featured Publication PURPOSE: The aim of this work is to investigate the feasibility of accelerating phase contrast magnetic resonance angiography (PC-MRA) by the fast imaging method of simplified skipped phase encoding and edge deghosting with array coil enhancement (S-SPEED- ... Full text Link to item Cite

Imaging system QA of a medical accelerator, Novalis Tx, for IGRT per TG 142: Our 1 year experience

Journal Article Journal of Applied Clinical Medical Physics · January 1, 2012 American Association of Physicists in Medicine (AAPM) task group (TG) 142 has recently published a report to update recommendations of the AAPM TG 40 report and add new recommendations concerning medical accelerators in the era of image-guided radiation th ... Full text Cite

Four-dimensional magnetic resonance imaging (4D-MRI) using image-based respiratory surrogate: a feasibility study.

Journal Article Med Phys · December 2011 Featured Publication PURPOSE: Four-dimensional computed tomography (4D-CT) has been widely used in radiation therapy to assess patient-specific breathing motion for determining individual safety margins. However, it has two major drawbacks: low soft-tissue contrast and an exce ... Full text Link to item Cite

Imaging Tumor Motion using 4D-MRI

Journal Article International Journal of Radiation Oncology*Biology*Physics · October 2011 Full text Cite

Imaging-Guided Localization for Stereotactic Radiosurgery of Multiple Intracranial Lesions with a Single Isocenter Setup

Journal Article International Journal of Radiation Oncology*Biology*Physics · October 2011 Full text Cite

Bevacizumab and Radiosurgery for Recurrent Malignant Glioma: Toxicity Results from a Prospective Pilot Study

Journal Article International Journal of Radiation Oncology*Biology*Physics · October 2011 Full text Cite

Evaluating Recurrent Gliomas with Diffusion-weighted MR Imaging Before and After Concurrent Radiosurgery and Bevacizumab

Journal Article International Journal of Radiation Oncology*Biology*Physics · October 2011 Full text Cite

Safety results from a prospective study of concurrent radiosurgery and bevacizumab for recurrent malignant glioma.

Journal Article J Clin Oncol · May 20, 2011 2082 Background: Most patients with a malignant glioma recur after primary chemoradiation. Bevacizumab (BVZ) has been shown in phase II trials to improve disease-free survival in patients with recurrent glioma. Retrospective studies of stereotactic radiosu ... Link to item Cite

Evaluation of integrated respiratory gating systems on a Novalis Tx system.

Journal Article J Appl Clin Med Phys · April 4, 2011 Featured Publication The purpose of this study was to investigate the accuracy of motion tracking and radiation delivery control of integrated gating systems on a Novalis Tx system. The study was performed on a Novalis Tx system, which is equipped with Varian Real-time Positio ... Full text Open Access Link to item Cite

TU‐E‐BRC‐08: Investigation of Anatomical Surrogate for 4DCT Imaging

Conference Medical Physics · January 1, 2011 Purpose: Respiratory signal for 4DCT is typically extracted using an external respiratory positioning management device (RPM) which is often inconvenient and time consuming. The efficiency of 4DCT imaging could be substantially improved if anatomical body ... Full text Cite

SU‐E‐T‐123: Evaluation of Integrated Gating Systems on a Novalis Tx System Using Quantitative Motion Tracking Analyses and Efficient Time‐Delay Measurements

Conference Medical Physics · January 1, 2011 Purpose: To investigate accuracy of motion tracking and radiation delivery controlling of integrated gating systems on a Novalis Tx system. Methods: The study was performed on a Novalis Tx system, which is equipped with Varian RPM and BrainLAB ExacTrac gat ... Full text Cite

MO‐F‐211‐04: Fast Phase Contrast MR Angiography with Simplified Skipped Phase Encoding and Edge Deghosting with Array Coil Enhancement (S‐ SPEED‐ACE)

Conference Medical Physics · January 1, 2011 Purpose: The aim of this work is to investigate the feasibility of accelerating phase contrast MR angiography by the fast imaging method of Simplified Skipped Phase Encoding and Edge Deghosting with Array Coil Enhancement (S‐SPEED‐ACE). Methods: The parall ... Full text Cite

Evaluation of motion measurement using cine MRI for image guided stereotactic body radiotherapy on a new phantom platform.

Journal Article J Radiosurg SBRT · 2011 The objective of this study is to investigate accuracy of motion tracking of cine magnetic resonance imaging (MRI) for image-guided stereotactic body radiotherapy. A phantom platform was developed in this work to fulfill the goal. The motion phantom consis ... Link to item Cite

Quality Assurance in Adaptive Radiation Therapy

Chapter · January 1, 2011 To ensure measurement accuracy, it is necessary to generate a comprehensive quality assurance (QA) program. “The ‘quality’ of radiation oncology can be defined as the totality of features or characteristics of the radiation oncology service that bear on it ... Full text Cite

Primary meningeal rhabdomyosarcoma.

Journal Article Sarcoma · 2011 Featured Publication Primary meningeal rhabdomyosarcoma is a rare primary brain malignancy, with scant case reports. While most reports of primary intracranial rhabdomyosarcoma occur in pediatric patients, a handful of cases in adult patients have been reported in the medical ... Full text Link to item Cite

Evaluation of integrated respiratory gating systems on a Novalis Tx system

Journal Article Journal of Applied Clinical Medical Physics · January 1, 2011 Featured Publication The purpose of this study was to investigate the accuracy of motion tracking and radiation delivery control of integrated gating systems on a Novalis Tx system. The study was performed on a Novalis Tx system, which is equipped with Varian Real-time Positio ... Full text Cite

Maximum intensity projection (MIP) imaging using slice-stacking MRIa).

Journal Article Med Phys · November 2010 Featured Publication PURPOSE: To evaluate the feasibility of acquiring maximum intensity projection (MIP) images using a novel slice-stacking MRI (SS-MRI) technique. METHODS: The proposed technique employed a steady state acquisition sequence to image multiple axial slices. At ... Full text Link to item Cite

Extracting Breathing Signal from Image Fourier Transform for Developing 4D-MRI

Conference International Journal of Radiation Oncology*Biology*Physics · November 2010 Full text Cite

Stereotactic Body Radiotherapy (SBRT) in Patients Previously Treated with External Beam Radiation Therapy

Conference International Journal of Radiation Oncology*Biology*Physics · November 2010 Full text Cite

Impact of volumetric modulated arc therapy technique on treatment with partial breast irradiation.

Journal Article Int J Radiat Oncol Biol Phys · September 1, 2010 Featured Publication PURPOSE: To investigate the technical feasibility of volumetric modulated arc therapy (V-MAT) in the delivery of partial breast irradiation (PBI). METHODS AND MATERIALS: V-MAT and the standard, three-dimensional conformal radiotherapy (3D-CRT), were compar ... Full text Link to item Cite

6D image guidance for spinal non-invasive stereotactic body radiation therapy: Comparison between ExacTrac X-ray 6D with kilo-voltage cone-beam CT.

Journal Article Radiother Oncol · April 2010 Featured Publication PURPOSE: To investigate setup discrepancies measured with ExacTrac X-ray 6 degree-of-freedom (6D) and cone-beam computed tomography (CBCT) for patients under treatments of stereotactic body radiation therapy (SBRT). MATERIALS AND METHODS: In this work, pha ... Full text Link to item Cite

Toward acquiring comprehensive radiosurgery field commissioning data using the PRESAGE/optical-CT 3D dosimetry system.

Journal Article Phys Med Biol · March 7, 2010 Featured Publication Achieving accurate small field dosimetry is challenging. This study investigates the utility of a radiochromic plastic PRESAGE read with optical-CT for the acquisition of radiosurgery field commissioning data from a Novalis Tx system with a high-definition ... Full text Link to item Cite

Accelerating non-contrast-enhanced MR angiography with inflow inversion recovery imaging by skipped phase encoding and edge deghosting (SPEED).

Journal Article J Magn Reson Imaging · March 2010 Featured Publication PURPOSE: To accelerate non-contrast-enhanced MR angiography (MRA) with inflow inversion recovery (IFIR) with a fast imaging method, Skipped Phase Encoding and Edge Deghosting (SPEED). MATERIALS AND METHODS: IFIR imaging uses a preparatory inversion pulse t ... Full text Link to item Cite

SU‐GG‐I‐140: Maximum Intensity Projection (MIP) Imaging Using Multi‐Slice Cine MRI

Conference Medical Physics · January 1, 2010 Purpose: To propose a novel method of acquiring Maximum Intensity Projection (MIP) images using multi‐slice cine MRI, termed as MRI‐MIP, and to evaluate its feasibility in quantifying motion magnitude. Materials and Methods: MRI‐MIP images are acquired usi ... Full text Cite

SU‐GG‐T‐530: Comparison of Coplanar and Non‐Coplanar Intensity Modulated Arc Techniques for Treatment of Intracranial Multi‐Focal Stereotactic Radiosurgery

Conference Medical Physics · January 1, 2010 Objectives: Intensity modulated arc therapy (IMAT) can potentially be a useful technique for the treatment of multi‐focal intracranial stereotactic radiosurgery (SRS) with a single isocenter setup. This study compares the effects of coplanar and non‐coplan ... Full text Cite

SU‐GG‐J‐67: Evaluating Dynamic Magnetic Resonance Imaging Using a New Design of Phantom: Validation with Fast Megavoltage Fluoroscopic Imaging

Conference Medical Physics · January 1, 2010 Purpose: To devlope a reliable and economic phantom for motion management study and investigate its feasibility in evaluating dynamic MRI. Method and Materials: Experiments was performed using an in‐house developed phantom that consists of a platform, a lo ... Full text Cite

TU‐B‐201B‐02: Self‐Sorted Four‐Dimensional CT Using Body Volume as Respiratory Surrogate

Conference Medical Physics · January 1, 2010 Purpose: To develop a self‐sorting four‐dimensional CT (4D‐CT) technique that uses body volume as the respiratory surrogate. Method and Materials: Respiratory signals are determined by the changes in body volume at each slice location as a function of imag ... Full text Cite

SU‐GG‐I‐148: Self‐Sorted Four‐Dimensional Magnetic Resonance Imaging: A Feasibility Study

Conference Medical Physics · January 1, 2010 Purpose: Considerable imaging dose to health tissue of patient from 4D‐CT is often a concern. This study is to develop a four‐dimensional magnetic resonance imaging (4D‐MRI) technique based on retrospective sorting strategy that uses body volume as respira ... Full text Cite

SU‐GG‐I‐24: Improving IGRT Efficiency Using GPU‐Based Ultrafast Reconstruction of DTS/CBCT and DRR

Conference Medical Physics · January 1, 2010 Purpose: One challenge of on‐line image‐guided radiation therapy is requirement of immediate availability of reconstructed 3D or 4D images for evaluation. This study is to develop a highly data‐parallel version and platform of accelerating reconstruction f ... Full text Cite

SU‐GG‐J‐62: Use Winston‐Lutz Test to Check Cone Beam CT Isocenter Accuracy for Imaging Guided Intracranial Stereotactic Radiosurgery

Conference Medical Physics · January 1, 2010 Objectives: Cone beam CT (CBCT) opens the era of three dimensional (3D) imaging guided stereotactic radiosurgery (SRS). The CBCT isocenter accuracy is critical for imaging guided SRS guidance. This study analyzes the daily quality assurance (QA) results of ... Full text Cite

SU‐GG‐J‐157: Evaluation of Volumetric Losses during Radiation Therapy Using Image Guidance of Electronic Portal Imaging Device

Conference Medical Physics · January 1, 2010 Purpose: Changes in patient volume, due to tumor shrinkage, dehydration, dysphagia and atrophy, could present issues in the accuracy of dosimetry throughout the course of treatment. The aim of this work is to study the dosimetric impacts of the volumetric ... Full text Cite

SU‐GG‐I‐144: Accelerating Non‐Contrast‐Enhanced MRA with Inflow Inversion Recovery by Using Skipped Phase Encoding and Edge Deghosting (SPEED)

Conference Medical Physics · January 1, 2010 Purpose: Non‐contrast‐enhanced MR angigraphy (MRA) has always been a valuable clinical tool to study vasculatural diseases. The recently arising concerns of constrast agents in contrast‐enhanced MRA encouraged more use of non‐contrast‐enhanced MRA. The aim ... Full text Cite

ExacTrac X-ray 6 degree-of-freedom image-guidance for intracranial non-invasive stereotactic radiotherapy: comparison with kilo-voltage cone-beam CT.

Journal Article Radiother Oncol · December 2009 Featured Publication BACKGROUND AND PURPOSE: To compare the residual setup errors measured with ExacTrac X-ray 6 degree-of-freedom (6D) and cone-beam computed tomography (CBCT) for a head phantom and patients receiving intracranial non-invasive fractionated stereotactic radiot ... Full text Link to item Cite

Six-dimensional Image Guidance for Spinal Noninvasive SRS/SBRT: Comparison between ExacTrac X-ray 6D with kV Cone-beam CT

Conference International Journal of Radiation Oncology*Biology*Physics · November 2009 Full text Cite

Imaging Guided Stereotactic Radiosurgery and its Accuracy Compared to Frame-based Localization

Conference International Journal of Radiation Oncology*Biology*Physics · November 2009 Full text Cite

Impact of collimator leaf width and treatment technique on stereotactic radiosurgery and radiotherapy plans for intra- and extracranial lesions.

Journal Article Radiat Oncol · January 21, 2009 Featured Publication BACKGROUND: This study evaluated the dosimetric impact of various treatment techniques as well as collimator leaf width (2.5 vs 5 mm) for three groups of tumors -- spine tumors, brain tumors abutting the brainstem, and liver tumors. These lesions often pre ... Full text Open Access Link to item Cite

Impact of collimator leaf width and treatment technique on stereotactic radiosurgery and radiotherapy plans for intra- and extracranial lesions

Journal Article Radiation Oncology · January 21, 2009 Background: This study evaluated the dosimetric impact of various treatment techniques as well as collimator leaf width (2.5 vs 5 mm) for three groups of tumors - spine tumors, brain tumors abutting the brainstem, and liver tumors. These lesions often pres ... Full text Cite

SU‐FF‐T‐309: Quality Assurance for Imaging Guided Stereotactic RadioSurgery with Novalis Tx™ System

Conference Medical Physics · January 1, 2009 Purpose: To present QA measurements over extended periods at our institute and recommend a QA program for image‐guided radiosurgery on Novalis Tx system. Method and Materials: Novalis Tx system is developed based on a Trilogy linear accelerator featuring B ... Full text Cite

SU‐EE‐A3‐02: Imaging Guided Frameless Stereotactic RadioSurgery Using CBCT 6D Image Registration and 6D Couch On Novalis Tx™ System

Conference Medical Physics · January 1, 2009 Purpose: To investigate localization accuracy for image‐guided frameless stereotactic‐radiosurgery (IG‐SRS) using CBCT 6D image registration and 6D‐couch on Novalis Tx system. Method and Materials: Novalis Tx system is a powerful radiosurgery system featur ... Full text Cite

SU‐FF‐T‐545: Feasibility Study for Treatment of Intracranial Multi‐Focal Stereotactic Radiosurgery with Multiple Intensity Modulated Arc Technique

Conference Medical Physics · January 1, 2009 Objectives: To investigate the feasibility of using an intensity modulated arc technique for multi‐focal intracranial stereotactic radiosurgery with a single isocenter setup to significantly decrease the treatment time. Methods: A Novalis Tx linear acceler ... Full text Cite

SU‐FF‐T‐548: Comparison of Cone‐Beam CT and Frame‐Based Localizations for Stereotactic Radiosurgery with Fixed Head Rings and Removable Frames

Conference Medical Physics · January 1, 2009 Objectives: To compare localization accuracy using both conventional frame‐based localizers and cone‐beam CT (CBCT) images for stereotactic radiosurgery (SRS). Methods: A SRS geometric phantom was used to verify the localization accuracy based on a SRS loc ... Full text Cite

SU‐FF‐T‐301: Clinical Implementation and Commission of Volumetric Modulated Arc Therapy

Conference Medical Physics · January 1, 2009 Purpose Volumetric modulated arc therapy (VMAT) is a rotational IMRT modality that combines dose rate modulation with gantry and MLC motion, thereby increasing the complexity of IMRT delivery. Effective implementation of this technology is still quite new ... Full text Cite

SU‐FF‐T‐314: Patient‐Specific Quality Assurance Techniques for RapidArc Radiotherapy

Conference Medical Physics · January 1, 2009 Purpose: To develop a patient‐specific quality assurance protocol for RapidArc™ radiotherapy. Method and Materials: Following the commissioning of RapidArc™ treatment delivery, we tested several methods of patient‐specific quality assurance (QA). Ion chamb ... Full text Cite

Efficient multiple acquisitions by Skipped Phase Encoding and Edge Deghosting (SPEED) using shared spatial information.

Journal Article Magn Reson Med · January 2009 Featured Publication The fast MRI method of Skipped Phase Encoding and Edge Deghosting (SPEED) is further developed to accelerate multiple acquisitions. In a single acquisition, SPEED first acquires three sparse ghosted edge maps with an undersampling factor of N/3, which are ... Full text Link to item Cite

Dosimetric characteristics of novalis Tx system with high definition multileaf collimator.

Journal Article Med Phys · October 2008 Featured Publication A new Novalis Tx system equipped with a high definition multileaf collimator (HDMLC) recently became available to perform both image-guided radiosurgery and conventional radiotherapy. It is capable of delivering a highly conformal radiation dose with three ... Full text Link to item Cite

Dosimetrical Evaluation of SRS/SBRT Techniques

Conference International Journal of Radiation Oncology*Biology*Physics · September 2008 Full text Cite

Can Cone Beam CT Replace Frame-based Localization for Stereotactic Radiosurgery?

Conference International Journal of Radiation Oncology*Biology*Physics · September 2008 Full text Cite

MRI-based Postimplant Dosimetric Assessment

Conference International Journal of Radiation Oncology*Biology*Physics · September 2008 Full text Cite

An automated intensity-weighted brachytherapy seed localization algorithm.

Journal Article Med Phys · March 2008 Featured Publication Brachytherapy has proven to be an effective treatment for various forms of cancer, whereby radioactive material is inserted directly into the body to maximize dosage to malignant tumors while preserving healthy tissue. In order to validate the preoperative ... Full text Link to item Cite

SU‐GG‐T‐446: Dosimetric Characteristics of High Definition Multi‐Leaf Collimator

Conference Medical Physics · January 1, 2008 Purpose: A new type of high‐definition multi‐leaf collimator (HD 120 MLC, Varian Medical Systems) is being introduced into clinical practice to improve the conformality of stereotactic radiation therapy and radiosurgery. Its leaf width at isocenter is 2.5 ... Full text Cite

SU‐GG‐T‐454: Localization Accuracy of Cone‐Beam CT Guided Radiosurgery as Investigated Utilizing a Geometric Phantom

Conference Medical Physics · January 1, 2008 Purpose: While the advantage of imaging guidance with cone beam CT (CBCT) guided radiosurgery is obvious, the localization accuracy of CBCT guided radiosurgery still remains a concern. This study utilized a geometric phantom with known target positions to ... Full text Cite

SU‐GG‐J‐177: The Application of An ASi‐Based EPID to Guide Intensity Modulated Radiation Therapy (IMRT) of Head‐And‐Neck Cancer

Conference Medical Physics · January 1, 2008 Purpose: In head‐and‐neck IMRT treatment, doses to targets and critical organs are affected by many factors including patient positioning, weight loss and tumor shrinkage. To ensure therapeutic effectiveness, re‐planning with a new CT is often conducted. H ... Full text Cite

SU‐EE‐A4‐04: Accelerating Breast Dynamic Contrast Enhanced MRI with Efficient Multiple Acquisitions by SPEED Using Shared Information

Conference Medical Physics · January 1, 2008 Purpose: The efficient multiple acquisition method using Skipped Phase Encoding and Edge Deghosting (SPEED) has been successfully demonstrated with a dynamic contrast enhanced (CE) mice tumor study; however, it has not been tested with any human subjects. ... Full text Cite

Simplified skipped phase encoding and edge deghosting (SPEED) for imaging sparse objects with applications to MRA.

Journal Article Med Phys · August 2007 Featured Publication The fast imaging method named skipped phase encoding and edge deghosting (SPEED) has been demonstrated to reduce scan time considerably with typical magnetic resonance imaging data. In this work, SPEED is simplified with improved efficiency to accelerate t ... Full text Link to item Cite

Automated brachytherapy seed localization using intensity-weighted feature extraction techniques

Journal Article 2007 4th IEEE International Symposium on Biomedical Imaging from Nano to Macro Proceedings · January 1, 2007 Brachytherapy has proven to be an effective treatment of various forms of cancer, whereby radioactive material is inserted directly into the body to maximize dosage to malignant tumors while preserving healthy tissue. In order to validate the pre-operative ... Full text Cite

Highly accelerated MRI by skipped phase encoding and edge deghosting with array coil enhancement (SPEED-ACE).

Journal Article Med Phys · October 2006 Featured Publication The fast MRI method of skipped phase encoding and edge deghosting (SPEED) is further developed with array coil enhancement, and thus is termed SPEED-ACE. In SPEED-ACE, k space is sparsely sampled with skipped phase encoding at every Nth step using a set of ... Full text Link to item Cite

Nonlinear phase correction with an extended statistical algorithm.

Journal Article IEEE Trans Med Imaging · June 2005 Featured Publication This paper presents a new magnetic resonance imaging (MRI) phase correction method. The linear phase correction method using autocorrelation proposed by Ahn and Cho (AC method) is extended to handle nonlinear terms, which are often important for polynomial ... Full text Link to item Cite

Problems created in attenuation-corrected SPECT images by artifacts in attenuation maps: a simulation study.

Journal Article J Nucl Med · February 2005 Featured Publication UNLABELLED: The importance of accurate attenuation correction, especially for imaging of the thorax region, is widely acknowledged. Appropriate compensation methods have been developed and introduced into clinical practice. Most of these methods use attenu ... Link to item Cite

Problems created in attenuation corrected SPECT images by artifacts in the attenuation maps

Journal Article IEEE Nuclear Science Symposium Conference Record · December 1, 2003 Attenuation of photons is a well recognized problem in SPECT, leading to artifacts and inaccuracies in reconstructed images. Most of the correction methods available in clinics use attenuation maps obtained with different transmission scanning systems. How ... Cite