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Immunological and virological mechanisms of vaccine-mediated protection against SIV and HIV.

Publication ,  Journal Article
Roederer, M; Keele, BF; Schmidt, SD; Mason, RD; Welles, HC; Fischer, W; Labranche, C; Foulds, KE; Louder, MK; Yang, Z-Y; Todd, J-PM; Buzby, AP ...
Published in: Nature
January 23, 2014

A major challenge for the development of a highly effective AIDS vaccine is the identification of mechanisms of protective immunity. To address this question, we used a nonhuman primate challenge model with simian immunodeficiency virus (SIV). We show that antibodies to the SIV envelope are necessary and sufficient to prevent infection. Moreover, sequencing of viruses from breakthrough infections revealed selective pressure against neutralization-sensitive viruses; we identified a two-amino-acid signature that alters antigenicity and confers neutralization resistance. A similar signature confers resistance of human immunodeficiency virus (HIV)-1 to neutralization by monoclonal antibodies against variable regions 1 and 2 (V1V2), suggesting that SIV and HIV share a fundamental mechanism of immune escape from vaccine-elicited or naturally elicited antibodies. These analyses provide insight into the limited efficacy seen in HIV vaccine trials.

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Published In

Nature

DOI

EISSN

1476-4687

Publication Date

January 23, 2014

Volume

505

Issue

7484

Start / End Page

502 / 508

Location

England

Related Subject Headings

  • env Gene Products, Human Immunodeficiency Virus
  • Simian immunodeficiency virus
  • Simian Immunodeficiency Virus
  • Simian Acquired Immunodeficiency Syndrome
  • SAIDS Vaccines
  • Risk
  • Phylogeny
  • Molecular Sequence Data
  • Male
  • Macaca mulatta
 

Citation

APA
Chicago
ICMJE
MLA
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Roederer, M., Keele, B. F., Schmidt, S. D., Mason, R. D., Welles, H. C., Fischer, W., … Mascola, J. R. (2014). Immunological and virological mechanisms of vaccine-mediated protection against SIV and HIV. Nature, 505(7484), 502–508. https://doi.org/10.1038/nature12893
Roederer, Mario, Brandon F. Keele, Stephen D. Schmidt, Rosemarie D. Mason, Hugh C. Welles, Will Fischer, Celia Labranche, et al. “Immunological and virological mechanisms of vaccine-mediated protection against SIV and HIV.Nature 505, no. 7484 (January 23, 2014): 502–8. https://doi.org/10.1038/nature12893.
Roederer M, Keele BF, Schmidt SD, Mason RD, Welles HC, Fischer W, et al. Immunological and virological mechanisms of vaccine-mediated protection against SIV and HIV. Nature. 2014 Jan 23;505(7484):502–8.
Roederer, Mario, et al. “Immunological and virological mechanisms of vaccine-mediated protection against SIV and HIV.Nature, vol. 505, no. 7484, Jan. 2014, pp. 502–08. Pubmed, doi:10.1038/nature12893.
Roederer M, Keele BF, Schmidt SD, Mason RD, Welles HC, Fischer W, Labranche C, Foulds KE, Louder MK, Yang Z-Y, Todd J-PM, Buzby AP, Mach LV, Shen L, Seaton KE, Ward BM, Bailer RT, Gottardo R, Gu W, Ferrari G, Alam SM, Denny TN, Montefiori DC, Tomaras GD, Korber BT, Nason MC, Seder RA, Koup RA, Letvin NL, Rao SS, Nabel GJ, Mascola JR. Immunological and virological mechanisms of vaccine-mediated protection against SIV and HIV. Nature. 2014 Jan 23;505(7484):502–508.

Published In

Nature

DOI

EISSN

1476-4687

Publication Date

January 23, 2014

Volume

505

Issue

7484

Start / End Page

502 / 508

Location

England

Related Subject Headings

  • env Gene Products, Human Immunodeficiency Virus
  • Simian immunodeficiency virus
  • Simian Immunodeficiency Virus
  • Simian Acquired Immunodeficiency Syndrome
  • SAIDS Vaccines
  • Risk
  • Phylogeny
  • Molecular Sequence Data
  • Male
  • Macaca mulatta