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The current epidemiology and clinical decisions surrounding acute respiratory infections.

Publication ,  Journal Article
Zaas, AK; Garner, BH; Tsalik, EL; Burke, T; Woods, CW; Ginsburg, GS
Published in: Trends Mol Med
October 2014
Published version (DOI) Link to item

Acute respiratory infection (ARI) is a common diagnosis in outpatient and emergent care settings. Currently available diagnostics are limited, creating uncertainty in the use of antibacterial, antiviral, or supportive care. Up to 72% of ambulatory care patients with ARI are treated with an antibacterial, despite only a small fraction actually needing one. Antibiotic overuse is not restricted to ambulatory care: ARI accounts for approximately 5 million emergency department (ED) visits annually in the USA, where 52-61% of such patients receive antibiotics. Thus, an accurate test for the presence or absence of viral or bacterial infection is needed. In this review, we focus on recent research showing that the host-response (genomic, proteomic, or miRNA) can accomplish this task.

Duke Scholars

Aimee Kirsch Zaas
Author Aimee Kirsch Zaas Medicine, Infectious Diseases
Ephraim Tsalik
Author Ephraim Tsalik Medicine, Infectious Diseases
Thomas Burke
Author Thomas Burke  
Christopher Wildrick Woods
Author Christopher Wildrick Woods Medicine, Infectious Diseases
Geoffrey Steven Ginsburg
Author Geoffrey Steven Ginsburg Medicine, Cardiology
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Published In

Trends Mol Med

DOI

10.1016/j.molmed.2014.08.001

EISSN

1471-499X

Publication Date

October 2014

Volume

20

Issue

10

Start / End Page

579 / 588

Location

England

Related Subject Headings

  • Respiratory Tract Infections
  • Proteomics
  • Molecular Diagnostic Techniques
  • MicroRNAs
  • Metabolomics
  • Immunology
  • Humans
  • Host-Pathogen Interactions
  • Gene Expression Profiling
  • Gene Expression
 

Citation

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Chicago
ICMJE
MLA
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Zaas, A. K., Garner, B. H., Tsalik, E. L., Burke, T., Woods, C. W., & Ginsburg, G. S. (2014). The current epidemiology and clinical decisions surrounding acute respiratory infections. Trends Mol Med, 20(10), 579–588. https://doi.org/10.1016/j.molmed.2014.08.001
Zaas, Aimee K., Bronwen H. Garner, Ephraim L. Tsalik, Thomas Burke, Christopher W. Woods, and Geoffrey S. Ginsburg. “The current epidemiology and clinical decisions surrounding acute respiratory infections.” Trends Mol Med 20, no. 10 (October 2014): 579–88. https://doi.org/10.1016/j.molmed.2014.08.001.
Zaas AK, Garner BH, Tsalik EL, Burke T, Woods CW, Ginsburg GS. The current epidemiology and clinical decisions surrounding acute respiratory infections. Trends Mol Med. 2014 Oct;20(10):579–88.
Zaas, Aimee K., et al. “The current epidemiology and clinical decisions surrounding acute respiratory infections.” Trends Mol Med, vol. 20, no. 10, Oct. 2014, pp. 579–88. Pubmed, doi:10.1016/j.molmed.2014.08.001.
Zaas AK, Garner BH, Tsalik EL, Burke T, Woods CW, Ginsburg GS. The current epidemiology and clinical decisions surrounding acute respiratory infections. Trends Mol Med. 2014 Oct;20(10):579–588.
Journal cover image

Published In

Trends Mol Med

DOI

10.1016/j.molmed.2014.08.001

EISSN

1471-499X

Publication Date

October 2014

Volume

20

Issue

10

Start / End Page

579 / 588

Location

England

Related Subject Headings

  • Respiratory Tract Infections
  • Proteomics
  • Molecular Diagnostic Techniques
  • MicroRNAs
  • Metabolomics
  • Immunology
  • Humans
  • Host-Pathogen Interactions
  • Gene Expression Profiling
  • Gene Expression