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Immune perturbations in HIV-1-infected individuals who make broadly neutralizing antibodies.

Publication ,  Journal Article
Moody, MA; Pedroza-Pacheco, I; Vandergrift, NA; Chui, C; Lloyd, KE; Parks, R; Soderberg, KA; Ogbe, AT; Cohen, MS; Liao, H-X; Gao, F; Kelsoe, G ...
Published in: Sci Immunol
July 29, 2016

Induction of broadly neutralizing antibodies (bnAbs) is a goal of HIV-1 vaccine development. bnAbs occur in some HIV-1-infected individuals and frequently have characteristics of autoantibodies. We have studied cohorts of HIV-1-infected individuals who made bnAbs and compared them with those who did not do so, and determined immune traits associated with the ability to produce bnAbs. HIV-1-infected individuals with bnAbs had a higher frequency of blood autoantibodies, a lower frequency of regulatory CD4+ T cells, a higher frequency of circulating memory T follicular helper CD4+ cells, and a higher T regulatory cell level of programmed cell death-1 expression compared with HIV-1-infected individuals without bnAbs. Thus, induction of HIV-1 bnAbs may require vaccination regimens that transiently mimic immunologic perturbations in HIV-1-infected individuals.

Duke Scholars

Published In

Sci Immunol

DOI

EISSN

2470-9468

Publication Date

July 29, 2016

Volume

1

Issue

1

Start / End Page

aag0851

Location

United States

Related Subject Headings

  • 3204 Immunology
  • 3202 Clinical sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Moody, M. A., Pedroza-Pacheco, I., Vandergrift, N. A., Chui, C., Lloyd, K. E., Parks, R., … Haynes, B. F. (2016). Immune perturbations in HIV-1-infected individuals who make broadly neutralizing antibodies. Sci Immunol, 1(1), aag0851. https://doi.org/10.1126/sciimmunol.aag0851

Published In

Sci Immunol

DOI

EISSN

2470-9468

Publication Date

July 29, 2016

Volume

1

Issue

1

Start / End Page

aag0851

Location

United States

Related Subject Headings

  • 3204 Immunology
  • 3202 Clinical sciences