Scholars@Duke

Erythromyeloid progenitors give rise to a population of osteoclasts that contribute to bone homeostasis and repair.

Publication ,  Journal Article
Yahara, Y; Barrientos, T; Tang, YJ; Puviindran, V; Nadesan, P; Zhang, H; Gibson, JR; Gregory, SG; Diao, Y; Xiang, Y; Qadri, YJ; Souma, T ...
Published in: Nat Cell Biol
January 2020
Published version (DOI) Link to item

Osteoclasts are multinucleated cells of the monocyte/macrophage lineage that degrade bone. Here, we used lineage tracing studies-labelling cells expressing Cx3cr1, Csf1r or Flt3-to identify the precursors of osteoclasts in mice. We identified an erythromyeloid progenitor (EMP)-derived osteoclast precursor population. Yolk-sac macrophages of EMP origin produced neonatal osteoclasts that can create a space for postnatal bone marrow haematopoiesis. Furthermore, EMPs gave rise to long-lasting osteoclast precursors that contributed to postnatal bone remodelling in both physiological and pathological settings. Our single-cell RNA-sequencing data showed that EMP-derived osteoclast precursors arose independently of the haematopoietic stem cell (HSC) lineage and the data from fate tracking of EMP and HSC lineages indicated the possibility of cell-cell fusion between these two lineages. Cx3cr1+ yolk-sac macrophage descendants resided in the adult spleen, and parabiosis experiments showed that these cells migrated through the bloodstream to the remodelled bone after injury.

Duke Scholars

Simon Gray Gregory
Author Simon Gray Gregory Neurosurgery, Neuro-Oncology
Yarui Diao
Author Yarui Diao Cell Biology
Tomokazu Souma
Author Tomokazu Souma Medicine, Nephrology
Mari L. Shinohara
Author Mari L. Shinohara Integrative Immunobiology
Benjamin Aaron Alman
Author Benjamin Aaron Alman Orthopaedic Surgery
Altmetric Attention Stats
Dimensions Citation Stats

Published In

Nat Cell Biol

DOI

10.1038/s41556-019-0437-8

EISSN

1476-4679

Publication Date

January 2020

Volume

22

Issue

1

Start / End Page

49 / 59

Location

England

Related Subject Headings

  • Yolk Sac
  • Osteoclasts
  • Mice
  • Macrophages
  • Homeostasis
  • Hematopoietic Stem Cells
  • Hematopoiesis
  • Developmental Biology
  • Cell Lineage
  • Cell Differentiation
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Yahara, Y., Barrientos, T., Tang, Y. J., Puviindran, V., Nadesan, P., Zhang, H., … Alman, B. A. (2020). Erythromyeloid progenitors give rise to a population of osteoclasts that contribute to bone homeostasis and repair. Nat Cell Biol, 22(1), 49–59. https://doi.org/10.1038/s41556-019-0437-8
Yahara, Yasuhito, Tomasa Barrientos, Yuning J. Tang, Vijitha Puviindran, Puviindran Nadesan, Hongyuan Zhang, Jason R. Gibson, et al. “Erythromyeloid progenitors give rise to a population of osteoclasts that contribute to bone homeostasis and repair.” Nat Cell Biol 22, no. 1 (January 2020): 49–59. https://doi.org/10.1038/s41556-019-0437-8.
Yahara Y, Barrientos T, Tang YJ, Puviindran V, Nadesan P, Zhang H, et al. Erythromyeloid progenitors give rise to a population of osteoclasts that contribute to bone homeostasis and repair. Nat Cell Biol. 2020 Jan;22(1):49–59.
Yahara, Yasuhito, et al. “Erythromyeloid progenitors give rise to a population of osteoclasts that contribute to bone homeostasis and repair.” Nat Cell Biol, vol. 22, no. 1, Jan. 2020, pp. 49–59. Pubmed, doi:10.1038/s41556-019-0437-8.
Yahara Y, Barrientos T, Tang YJ, Puviindran V, Nadesan P, Zhang H, Gibson JR, Gregory SG, Diao Y, Xiang Y, Qadri YJ, Souma T, Shinohara ML, Alman BA. Erythromyeloid progenitors give rise to a population of osteoclasts that contribute to bone homeostasis and repair. Nat Cell Biol. 2020 Jan;22(1):49–59.

Published In

Nat Cell Biol

DOI

10.1038/s41556-019-0437-8

EISSN

1476-4679

Publication Date

January 2020

Volume

22

Issue

1

Start / End Page

49 / 59

Location

England

Related Subject Headings

  • Yolk Sac
  • Osteoclasts
  • Mice
  • Macrophages
  • Homeostasis
  • Hematopoietic Stem Cells
  • Hematopoiesis
  • Developmental Biology
  • Cell Lineage
  • Cell Differentiation