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Strategies for HIV-1 vaccines that induce broadly neutralizing antibodies.

Publication ,  Journal Article
Haynes, BF; Wiehe, K; Borrow, P; Saunders, KO; Korber, B; Wagh, K; McMichael, AJ; Kelsoe, G; Hahn, BH; Alt, F; Shaw, GM
Published in: Nat Rev Immunol
March 2023
Published version (DOI) Link to item

After nearly four decades of research, a safe and effective HIV-1 vaccine remains elusive. There are many reasons why the development of a potent and durable HIV-1 vaccine is challenging, including the extraordinary genetic diversity of HIV-1 and its complex mechanisms of immune evasion. HIV-1 envelope glycoproteins are poorly recognized by the immune system, which means that potent broadly neutralizing antibodies (bnAbs) are only infrequently induced in the setting of HIV-1 infection or through vaccination. Thus, the biology of HIV-1-host interactions necessitates novel strategies for vaccine development to be designed to activate and expand rare bnAb-producing B cell lineages and to select for the acquisition of critical improbable bnAb mutations. Here we discuss strategies for the induction of potent and broad HIV-1 bnAbs and outline the steps that may be necessary for ultimate success.

Duke Scholars

Garnett H. Kelsoe
Author Garnett H. Kelsoe Integrative Immunobiology
Kevin J Wiehe
Author Kevin J Wiehe Medicine, Duke Human Vaccine Institute
Kevin O'Neil Saunders
Author Kevin O'Neil Saunders Surgery, Surgical Sciences
Kshitij G. Wagh
Author Kshitij G. Wagh Duke Human Vaccine Institute
Barton Ford Haynes
Author Barton Ford Haynes Medicine, Duke Human Vaccine Institute
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Published In

Nat Rev Immunol

DOI

10.1038/s41577-022-00753-w

EISSN

1474-1741

Publication Date

March 2023

Volume

23

Issue

3

Start / End Page

142 / 158

Location

England

Related Subject Headings

  • Immunology
  • Humans
  • HIV-1
  • HIV Infections
  • HIV Antibodies
  • Broadly Neutralizing Antibodies
  • Antigens, Viral
  • Antibodies, Neutralizing
  • AIDS Vaccines
  • 3204 Immunology
 

Citation

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Haynes, B. F., Wiehe, K., Borrow, P., Saunders, K. O., Korber, B., Wagh, K., … Shaw, G. M. (2023). Strategies for HIV-1 vaccines that induce broadly neutralizing antibodies. Nat Rev Immunol, 23(3), 142–158. https://doi.org/10.1038/s41577-022-00753-w
Haynes, Barton F., Kevin Wiehe, Persephone Borrow, Kevin O. Saunders, Bette Korber, Kshitij Wagh, Andrew J. McMichael, et al. “Strategies for HIV-1 vaccines that induce broadly neutralizing antibodies.” Nat Rev Immunol 23, no. 3 (March 2023): 142–58. https://doi.org/10.1038/s41577-022-00753-w.
Haynes BF, Wiehe K, Borrow P, Saunders KO, Korber B, Wagh K, et al. Strategies for HIV-1 vaccines that induce broadly neutralizing antibodies. Nat Rev Immunol. 2023 Mar;23(3):142–58.
Haynes, Barton F., et al. “Strategies for HIV-1 vaccines that induce broadly neutralizing antibodies.” Nat Rev Immunol, vol. 23, no. 3, Mar. 2023, pp. 142–58. Pubmed, doi:10.1038/s41577-022-00753-w.
Haynes BF, Wiehe K, Borrow P, Saunders KO, Korber B, Wagh K, McMichael AJ, Kelsoe G, Hahn BH, Alt F, Shaw GM. Strategies for HIV-1 vaccines that induce broadly neutralizing antibodies. Nat Rev Immunol. 2023 Mar;23(3):142–158.

Published In

Nat Rev Immunol

DOI

10.1038/s41577-022-00753-w

EISSN

1474-1741

Publication Date

March 2023

Volume

23

Issue

3

Start / End Page

142 / 158

Location

England

Related Subject Headings

  • Immunology
  • Humans
  • HIV-1
  • HIV Infections
  • HIV Antibodies
  • Broadly Neutralizing Antibodies
  • Antigens, Viral
  • Antibodies, Neutralizing
  • AIDS Vaccines
  • 3204 Immunology