Scholars@Duke publication: Strategies for HIV-1 vaccines that induce broadly neutralizing antibodies.

Strategies for HIV-1 vaccines that induce broadly neutralizing antibodies.

Publication , Journal Article

Haynes, BF; Wiehe, K; Borrow, P; Saunders, KO; Korber, B; Wagh, K; McMichael, AJ; Kelsoe, G; Hahn, BH; Alt, F; Shaw, GM

Published in: Nature reviews. Immunology

March 2023

After nearly four decades of research, a safe and effective HIV-1 vaccine remains elusive. There are many reasons why the development of a potent and durable HIV-1 vaccine is challenging, including the extraordinary genetic diversity of HIV-1 and its complex mechanisms of immune evasion. HIV-1 envelope glycoproteins are poorly recognized by the immune system, which means that potent broadly neutralizing antibodies (bnAbs) are only infrequently induced in the setting of HIV-1 infection or through vaccination. Thus, the biology of HIV-1-host interactions necessitates novel strategies for vaccine development to be designed to activate and expand rare bnAb-producing B cell lineages and to select for the acquisition of critical improbable bnAb mutations. Here we discuss strategies for the induction of potent and broad HIV-1 bnAbs and outline the steps that may be necessary for ultimate success.

Duke Scholars

Author Kevin O'Neil Saunders Surgery, Surgical Sciences

Author Garnett H. Kelsoe Integrative Immunobiology

Author Kevin J Wiehe Medicine, Duke Human Vaccine Institute

Author Kshitij G. Wagh Duke Human Vaccine Institute

Author Barton Ford Haynes Medicine, Duke Human Vaccine Institute

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Published In

Nature reviews. Immunology

DOI

10.1038/s41577-022-00753-w

EISSN

1474-1741

ISSN

1474-1733

Publication Date

March 2023

Volume

Issue

Start / End Page

142 / 158

Related Subject Headings

Immunology
Humans
HIV-1
HIV Infections
HIV Antibodies
Broadly Neutralizing Antibodies
Antigens, Viral
Antibodies, Neutralizing
AIDS Vaccines
3204 Immunology

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APA

Chicago

ICMJE

MLA

NLM

Haynes, B. F., Wiehe, K., Borrow, P., Saunders, K. O., Korber, B., Wagh, K., … Shaw, G. M. (2023). Strategies for HIV-1 vaccines that induce broadly neutralizing antibodies. Nature Reviews. Immunology, 23(3), 142–158. https://doi.org/10.1038/s41577-022-00753-w

Haynes, Barton F., Kevin Wiehe, Persephone Borrow, Kevin O. Saunders, Bette Korber, Kshitij Wagh, Andrew J. McMichael, et al. “Strategies for HIV-1 vaccines that induce broadly neutralizing antibodies.” Nature Reviews. Immunology 23, no. 3 (March 2023): 142–58. https://doi.org/10.1038/s41577-022-00753-w.

Haynes BF, Wiehe K, Borrow P, Saunders KO, Korber B, Wagh K, et al. Strategies for HIV-1 vaccines that induce broadly neutralizing antibodies. Nature reviews Immunology. 2023 Mar;23(3):142–58.

Haynes, Barton F., et al. “Strategies for HIV-1 vaccines that induce broadly neutralizing antibodies.” Nature Reviews. Immunology, vol. 23, no. 3, Mar. 2023, pp. 142–58. Epmc, doi:10.1038/s41577-022-00753-w.

Haynes BF, Wiehe K, Borrow P, Saunders KO, Korber B, Wagh K, McMichael AJ, Kelsoe G, Hahn BH, Alt F, Shaw GM. Strategies for HIV-1 vaccines that induce broadly neutralizing antibodies. Nature reviews Immunology. 2023 Mar;23(3):142–158.

Published In

Nature reviews. Immunology

DOI

10.1038/s41577-022-00753-w

EISSN

1474-1741

ISSN

1474-1733

Publication Date

March 2023

Volume

Issue

Start / End Page

142 / 158

Related Subject Headings

Immunology
Humans
HIV-1
HIV Infections
HIV Antibodies
Broadly Neutralizing Antibodies
Antigens, Viral
Antibodies, Neutralizing
AIDS Vaccines
3204 Immunology