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Strategies for HIV-1 vaccines that induce broadly neutralizing antibodies.

Publication ,  Journal Article
Haynes, BF; Wiehe, K; Borrow, P; Saunders, KO; Korber, B; Wagh, K; McMichael, AJ; Kelsoe, G; Hahn, BH; Alt, F; Shaw, GM
Published in: Nat Rev Immunol
March 2023

After nearly four decades of research, a safe and effective HIV-1 vaccine remains elusive. There are many reasons why the development of a potent and durable HIV-1 vaccine is challenging, including the extraordinary genetic diversity of HIV-1 and its complex mechanisms of immune evasion. HIV-1 envelope glycoproteins are poorly recognized by the immune system, which means that potent broadly neutralizing antibodies (bnAbs) are only infrequently induced in the setting of HIV-1 infection or through vaccination. Thus, the biology of HIV-1-host interactions necessitates novel strategies for vaccine development to be designed to activate and expand rare bnAb-producing B cell lineages and to select for the acquisition of critical improbable bnAb mutations. Here we discuss strategies for the induction of potent and broad HIV-1 bnAbs and outline the steps that may be necessary for ultimate success.

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Published In

Nat Rev Immunol

DOI

EISSN

1474-1741

Publication Date

March 2023

Volume

23

Issue

3

Start / End Page

142 / 158

Location

England

Related Subject Headings

  • Immunology
  • Humans
  • HIV-1
  • HIV Infections
  • HIV Antibodies
  • Broadly Neutralizing Antibodies
  • Antigens, Viral
  • Antibodies, Neutralizing
  • AIDS Vaccines
  • 3204 Immunology
 

Citation

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Haynes, B. F., Wiehe, K., Borrow, P., Saunders, K. O., Korber, B., Wagh, K., … Shaw, G. M. (2023). Strategies for HIV-1 vaccines that induce broadly neutralizing antibodies. Nat Rev Immunol, 23(3), 142–158. https://doi.org/10.1038/s41577-022-00753-w
Haynes, Barton F., Kevin Wiehe, Persephone Borrow, Kevin O. Saunders, Bette Korber, Kshitij Wagh, Andrew J. McMichael, et al. “Strategies for HIV-1 vaccines that induce broadly neutralizing antibodies.Nat Rev Immunol 23, no. 3 (March 2023): 142–58. https://doi.org/10.1038/s41577-022-00753-w.
Haynes BF, Wiehe K, Borrow P, Saunders KO, Korber B, Wagh K, et al. Strategies for HIV-1 vaccines that induce broadly neutralizing antibodies. Nat Rev Immunol. 2023 Mar;23(3):142–58.
Haynes, Barton F., et al. “Strategies for HIV-1 vaccines that induce broadly neutralizing antibodies.Nat Rev Immunol, vol. 23, no. 3, Mar. 2023, pp. 142–58. Pubmed, doi:10.1038/s41577-022-00753-w.
Haynes BF, Wiehe K, Borrow P, Saunders KO, Korber B, Wagh K, McMichael AJ, Kelsoe G, Hahn BH, Alt F, Shaw GM. Strategies for HIV-1 vaccines that induce broadly neutralizing antibodies. Nat Rev Immunol. 2023 Mar;23(3):142–158.

Published In

Nat Rev Immunol

DOI

EISSN

1474-1741

Publication Date

March 2023

Volume

23

Issue

3

Start / End Page

142 / 158

Location

England

Related Subject Headings

  • Immunology
  • Humans
  • HIV-1
  • HIV Infections
  • HIV Antibodies
  • Broadly Neutralizing Antibodies
  • Antigens, Viral
  • Antibodies, Neutralizing
  • AIDS Vaccines
  • 3204 Immunology