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Immunization with germ line-targeting SOSIP trimers elicits broadly neutralizing antibody precursors in infant macaques.

Publication ,  Journal Article
Nelson, AN; Shen, X; Vekatayogi, S; Zhang, S; Ozorowski, G; Dennis, M; Sewall, LM; Milligan, E; Davis, D; Cross, KA; Chen, Y; van Schooten, J ...
Published in: Sci Immunol
August 30, 2024

Adolescents are a growing population of people living with HIV. The period between weaning and sexual debut presents a low-risk window for HIV acquisition, making early childhood an ideal time for implementing an immunization regimen. Because the elicitation of broadly neutralizing antibodies (bnAbs) is critical for an effective HIV vaccine, our goal was to assess the ability of a bnAb B cell lineage-designed HIV envelope SOSIP (protein stabilized by a disulfide bond between gp120-gp41-named "SOS"-and an isoleucine-to-proline point mutation-named "IP"-at residue 559) to induce precursor CD4 binding site (CD4bs)-targeting bnAbs in early life. Infant rhesus macaques received either a BG505 SOSIP, based on the infant BG505 transmitted/founder virus, or the CD4bs germ line-targeting BG505 SOSIP GT1.1 (n = 5 per group). Although both strategies induced durable, high-magnitude plasma autologous virus neutralization responses, only GT1.1-immunized infants (n = 3 of 5) exhibited VRC01-like CD4bs bnAb precursor development. Thus, a multidose immunization regimen with bnAb lineage-designed SOSIPs shows promise for inducing early B cell responses with the potential to mature into protective HIV bnAbs before sexual debut.

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Published In

Sci Immunol

DOI

EISSN

2470-9468

Publication Date

August 30, 2024

Volume

9

Issue

98

Start / End Page

eadm7097

Location

United States

Related Subject Headings

  • env Gene Products, Human Immunodeficiency Virus
  • Macaca mulatta
  • Immunization
  • Humans
  • HIV-1
  • HIV Infections
  • HIV Antibodies
  • Germ Cells
  • Broadly Neutralizing Antibodies
  • Antibodies, Neutralizing
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Nelson, A. N., Shen, X., Vekatayogi, S., Zhang, S., Ozorowski, G., Dennis, M., … Permar, S. R. (2024). Immunization with germ line-targeting SOSIP trimers elicits broadly neutralizing antibody precursors in infant macaques. Sci Immunol, 9(98), eadm7097. https://doi.org/10.1126/sciimmunol.adm7097
Nelson, Ashley N., Xiaoying Shen, Sravani Vekatayogi, Shiyu Zhang, Gabriel Ozorowski, Maria Dennis, Leigh M. Sewall, et al. “Immunization with germ line-targeting SOSIP trimers elicits broadly neutralizing antibody precursors in infant macaques.Sci Immunol 9, no. 98 (August 30, 2024): eadm7097. https://doi.org/10.1126/sciimmunol.adm7097.
Nelson AN, Shen X, Vekatayogi S, Zhang S, Ozorowski G, Dennis M, et al. Immunization with germ line-targeting SOSIP trimers elicits broadly neutralizing antibody precursors in infant macaques. Sci Immunol. 2024 Aug 30;9(98):eadm7097.
Nelson, Ashley N., et al. “Immunization with germ line-targeting SOSIP trimers elicits broadly neutralizing antibody precursors in infant macaques.Sci Immunol, vol. 9, no. 98, Aug. 2024, p. eadm7097. Pubmed, doi:10.1126/sciimmunol.adm7097.
Nelson AN, Shen X, Vekatayogi S, Zhang S, Ozorowski G, Dennis M, Sewall LM, Milligan E, Davis D, Cross KA, Chen Y, van Schooten J, Eudailey J, Isaac J, Memon S, Weinbaum C, Gao H, Stanfield-Oakley S, Byrd A, Chutkan S, Berendam S, Cronin K, Yasmeen A, Alam S, LaBranche CC, Rogers K, Shirreff L, Cupo A, Derking R, Villinger F, Klasse PJ, Ferrari G, Williams WB, Hudgens MG, Ward AB, Montefiori DC, Van Rompay KKA, Wiehe K, Moore JP, Sanders RW, De Paris K, Permar SR. Immunization with germ line-targeting SOSIP trimers elicits broadly neutralizing antibody precursors in infant macaques. Sci Immunol. 2024 Aug 30;9(98):eadm7097.

Published In

Sci Immunol

DOI

EISSN

2470-9468

Publication Date

August 30, 2024

Volume

9

Issue

98

Start / End Page

eadm7097

Location

United States

Related Subject Headings

  • env Gene Products, Human Immunodeficiency Virus
  • Macaca mulatta
  • Immunization
  • Humans
  • HIV-1
  • HIV Infections
  • HIV Antibodies
  • Germ Cells
  • Broadly Neutralizing Antibodies
  • Antibodies, Neutralizing