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Genomic signatures to guide the use of chemotherapeutics.

Publication ,  Other
Potti, A; Dressman, HK; Bild, A; Riedel, RF; Chan, G; Sayer, R; Cragun, J; Cottrill, H; Kelley, MJ; Petersen, R; Harpole, D; Marks, J ...
Published in: Nat Med
November 2006

Using in vitro drug sensitivity data coupled with Affymetrix microarray data, we developed gene expression signatures that predict sensitivity to individual chemotherapeutic drugs. Each signature was validated with response data from an independent set of cell line studies. We further show that many of these signatures can accurately predict clinical response in individuals treated with these drugs. Notably, signatures developed to predict response to individual agents, when combined, could also predict response to multidrug regimens. Finally, we integrated the chemotherapy response signatures with signatures of oncogenic pathway deregulation to identify new therapeutic strategies that make use of all available drugs. The development of gene expression profiles that can predict response to commonly used cytotoxic agents provides opportunities to better use these drugs, including using them in combination with existing targeted therapies.

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Published In

Nat Med

DOI

ISSN

1078-8956

Publication Date

November 2006

Volume

12

Issue

11

Start / End Page

1294 / 1300

Location

United States

Related Subject Headings

  • Taxoids
  • Pharmacogenetics
  • Immunology
  • Humans
  • Genome, Human
  • Gene Expression
  • Docetaxel
  • Cell Line, Tumor
  • Antineoplastic Combined Chemotherapy Protocols
  • 42 Health sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Potti, A., Dressman, H. K., Bild, A., Riedel, R. F., Chan, G., Sayer, R., … Nevins, J. R. (2006). Genomic signatures to guide the use of chemotherapeutics. Nat Med. United States. https://doi.org/10.1038/nm1491
Potti, Anil, Holly K. Dressman, Andrea Bild, Richard F. Riedel, Gina Chan, Robyn Sayer, Janiel Cragun, et al. “Genomic signatures to guide the use of chemotherapeutics.Nat Med, November 2006. https://doi.org/10.1038/nm1491.
Potti A, Dressman HK, Bild A, Riedel RF, Chan G, Sayer R, et al. Genomic signatures to guide the use of chemotherapeutics. Vol. 12, Nat Med. 2006. p. 1294–300.
Potti, Anil, et al. “Genomic signatures to guide the use of chemotherapeutics.Nat Med, vol. 12, no. 11, Nov. 2006, pp. 1294–300. Pubmed, doi:10.1038/nm1491.
Potti A, Dressman HK, Bild A, Riedel RF, Chan G, Sayer R, Cragun J, Cottrill H, Kelley MJ, Petersen R, Harpole D, Marks J, Berchuck A, Ginsburg GS, Febbo P, Lancaster J, Nevins JR. Genomic signatures to guide the use of chemotherapeutics. Nat Med. 2006. p. 1294–1300.

Published In

Nat Med

DOI

ISSN

1078-8956

Publication Date

November 2006

Volume

12

Issue

11

Start / End Page

1294 / 1300

Location

United States

Related Subject Headings

  • Taxoids
  • Pharmacogenetics
  • Immunology
  • Humans
  • Genome, Human
  • Gene Expression
  • Docetaxel
  • Cell Line, Tumor
  • Antineoplastic Combined Chemotherapy Protocols
  • 42 Health sciences