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Prosthetic valve endocarditis due to coagulase-negative staphylococci: findings from the International Collaboration on Endocarditis Merged Database.

Publication ,  Journal Article
Lalani, T; Kanafani, ZA; Chu, VH; Moore, L; Corey, GR; Pappas, P; Woods, CW; Cabell, CH; Hoen, B; Selton-Suty, C; Doco-Lecompte, T; Raoult, D ...
Published in: Eur J Clin Microbiol Infect Dis
June 2006

Infective endocarditis due to coagulase-negative staphylococci is increasingly recognized as a difficult-to-treat disease associated with poor outcome. The aim of this report is to describe the characteristics and outcome of patients with prosthetic valve endocarditis (PVE) due to coagulase-negative staphylococci versus those of patients with PVE due to Staphylococcus aureus and viridans streptococci. Patients were identified through the International Collaboration on Endocarditis Merged Database. A total of 54 cases of coagulase-negative staphylococci PVE, 58 cases of S. aureus PVE, and 63 cases of viridans-streptococci-related PVE were available for analysis. There was no difference between the three groups with respect to the type of valve involved or the rate of embolization. However, heart failure was encountered more frequently with coagulase-negative staphylococci (54%) than with either S. aureus (33%; p=0.03) or viridans streptococci (32%; p=0.02). In addition, valvular abscesses complicated 39% of infections due to coagulase-negative staphylococci compared with 22% of those due to S. aureus (p=0.06) and 6% of those due to viridans streptococci (p<0.001). Mortality was highest in patients with S. aureus and coagulase-negative staphylococcal endocarditis (47 and 36%, respectively; p=0.22) and was considerably lower in patients with viridans streptococcal endocarditis (p=0.002 compared to patients with coagulase-negative staphylococcal endocarditis). The results of this analysis demonstrate the aggressive nature of coagulase-negative staphylococcal PVE and the substantially greater morbidity and mortality associated with this infection compared to PVE caused by other pathogens.

Duke Scholars

Published In

Eur J Clin Microbiol Infect Dis

DOI

ISSN

0934-9723

Publication Date

June 2006

Volume

25

Issue

6

Start / End Page

365 / 368

Location

Germany

Related Subject Headings

  • Viridans Streptococci
  • Treatment Outcome
  • Streptococcal Infections
  • Staphylococcus
  • Staphylococcal Infections
  • Middle Aged
  • Microbiology
  • Male
  • Humans
  • Heart Valve Prosthesis
 

Citation

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MLA
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Lalani, T., Kanafani, Z. A., Chu, V. H., Moore, L., Corey, G. R., Pappas, P., … International Collaboration on Endocarditis Merged Database Study Group, . (2006). Prosthetic valve endocarditis due to coagulase-negative staphylococci: findings from the International Collaboration on Endocarditis Merged Database. Eur J Clin Microbiol Infect Dis, 25(6), 365–368. https://doi.org/10.1007/s10096-006-0141-z
Lalani, T., Z. A. Kanafani, V. H. Chu, L. Moore, G. R. Corey, P. Pappas, C. W. Woods, et al. “Prosthetic valve endocarditis due to coagulase-negative staphylococci: findings from the International Collaboration on Endocarditis Merged Database.Eur J Clin Microbiol Infect Dis 25, no. 6 (June 2006): 365–68. https://doi.org/10.1007/s10096-006-0141-z.
Lalani T, Kanafani ZA, Chu VH, Moore L, Corey GR, Pappas P, et al. Prosthetic valve endocarditis due to coagulase-negative staphylococci: findings from the International Collaboration on Endocarditis Merged Database. Eur J Clin Microbiol Infect Dis. 2006 Jun;25(6):365–8.
Lalani, T., et al. “Prosthetic valve endocarditis due to coagulase-negative staphylococci: findings from the International Collaboration on Endocarditis Merged Database.Eur J Clin Microbiol Infect Dis, vol. 25, no. 6, June 2006, pp. 365–68. Pubmed, doi:10.1007/s10096-006-0141-z.
Lalani T, Kanafani ZA, Chu VH, Moore L, Corey GR, Pappas P, Woods CW, Cabell CH, Hoen B, Selton-Suty C, Doco-Lecompte T, Chirouze C, Raoult D, Miro JM, Mestres CA, Olaison L, Eykyn S, Abrutyn E, Fowler VG, International Collaboration on Endocarditis Merged Database Study Group. Prosthetic valve endocarditis due to coagulase-negative staphylococci: findings from the International Collaboration on Endocarditis Merged Database. Eur J Clin Microbiol Infect Dis. 2006 Jun;25(6):365–368.
Journal cover image

Published In

Eur J Clin Microbiol Infect Dis

DOI

ISSN

0934-9723

Publication Date

June 2006

Volume

25

Issue

6

Start / End Page

365 / 368

Location

Germany

Related Subject Headings

  • Viridans Streptococci
  • Treatment Outcome
  • Streptococcal Infections
  • Staphylococcus
  • Staphylococcal Infections
  • Middle Aged
  • Microbiology
  • Male
  • Humans
  • Heart Valve Prosthesis