Dequing Wu

Journal Article J Alzheimers Dis · 2024 Relationships between patterns of aging-changes in bodyweight and AD are not fully understood. We compared mean age-trajectories of weight between those who did and did not develop late-onset-AD, and evaluated impact of age at maximum weight (AgeMax), and ... Full text Link to item Cite

How are APOE4, changes in body weight, and longevity related? Insights from a causal mediation analysis.

Journal Article Frontiers in aging · January 2024 The ε4 allele of the APOE gene (APOE4) is known for its negative association with human longevity; however, the mechanism is unclear. APOE4 is also linked to changes in body weight, and the latter changes were associated with survival in some ... Full text Cite

Interactions between genes involved in physiological dysregulation and axon guidance: role in Alzheimer's disease.

Journal Article Front Genet · 2023 Dysregulation of physiological processes may contribute to Alzheimer's disease (AD) development. We previously found that an increase in the level of physiological dysregulation (PD) in the aging body is associated with declining resilience and robustness ... Full text Link to item Cite

Interplay between stress-related genes may influence Alzheimer's disease development: The results of genetic interaction analyses of human data.

Journal Article Mechanisms of ageing and development · June 2021 Emerging evidence from experimental and clinical research suggests that stress-related genes may play key roles in AD development. The fact that genome-wide association studies were not able to detect a contribution of such genes to AD indicates the possib ... Full text Cite

Interactions Between Genes From Aging Pathways May Influence Human Lifespan and Improve Animal to Human Translation.

Journal Article Frontiers in cell and developmental biology · January 2021 A major goal of aging research is identifying genetic targets that could be used to slow or reverse aging - changes in the body and extend limits of human lifespan. However, majority of genes that showed the anti-aging and pro-survival effects in animal mo ... Full text Cite

Roles of interacting stress-related genes in lifespan regulation: insights for translating experimental findings to humans.

Journal Article Journal of translational genetics and genomics · January 2021 AimExperimental studies provided numerous evidence that caloric/dietary restriction may improve health and increase the lifespan of laboratory animals, and that the interplay among molecules that sense cellular stress signals and those regulating ... Cite

Genetics of physiological dysregulation: findings from the long life family study using joint models.

Journal Article Aging · April 2020 Recently, Mahalanobis distance (DM) was suggested as a statistical measure of physiological dysregulation in aging individuals. We constructed DM variants using sets of biomarkers collected at the two visits of the Long Life Family St ... Full text Cite

Composite Measure of Physiological Dysregulation as a Predictor of Mortality: The Long Life Family Study.

Journal Article Frontiers in public health · January 2020 Biological aging results in changes in an organism that accumulate over age in a complex fashion across different regulatory systems, and their cumulative effect manifests in increased physiological dysregulation (PD) and declining robustness and resilienc ... Full text Cite

Genetics of Human Longevity From Incomplete Data: New Findings From the Long Life Family Study.

Journal Article The journals of gerontology. Series A, Biological sciences and medical sciences · October 2018 The special design of the Long Life Family Study provides a unique opportunity to investigate the genetics of human longevity by analyzing data on exceptional lifespans in families. In this article, we performed two series of genome wide association studie ... Full text Cite

Hidden heterogeneity in Alzheimer's disease: Insights from genetic association studies and other analyses.

Journal Article Experimental gerontology · July 2018 Despite evident success in clarifying many important features of Alzheimer's disease (AD) the efficient methods of its prevention and treatment are not yet available. The reasons are likely to be the fact that AD is a multifactorial and heterogeneous healt ... Full text Cite

How Well Does the Family Longevity Selection Score Work: A Validation Test Using the Utah Population Database.

Journal Article Frontiers in public health · January 2018 The Family Longevity Selection Score (FLoSS) was used to select families for the Long Life Family Study (LLFS) but has never been validated in other populations. The goal of this paper is to validate how well the FLoSS-based selection procedure works in an ... Full text Cite

Uncoupling associations of risk alleles with endophenotypes and phenotypes: insights from the ApoB locus and heart-related traits.

Journal Article Aging cell · February 2017 Traditionally, genomewide association studies (GWAS) have emphasized the benefits of large samples in the analyses of age-related traits rather than their specific properties. We adopted a realistic concept of genetic susceptibility to inherently heterogen ... Full text Open Access Cite

Criteria to assess potential reverse innovations: opportunities for shared learning between high- and low-income countries.

Journal Article Global Health · January 25, 2017 BACKGROUND: Low- and middle-income countries (LMICs) are developing novel approaches to healthcare that may be relevant to high-income countries (HICs). These include products, services, organizational processes, or policies that improve access, cost, or e ... Full text Open Access Link to item Cite

Protective role of the apolipoprotein E2 allele in age-related disease traits and survival: evidence from the Long Life Family Study.

Journal Article Biogerontology · November 2016 The apolipoprotein E (apoE) is a classic example of a gene exhibiting pleiotropism. We examine potential pleiotropic associations of the apoE2 allele in three biodemographic cohorts of long-living individuals, offspring, and spouses from the Long Life Fami ... Full text Open Access Cite

Pleiotropic Associations of Allelic Variants in a 2q22 Region with Risks of Major Human Diseases and Mortality.

Journal Article PLoS genetics · November 2016 Gaining insights into genetic predisposition to age-related diseases and lifespan is a challenging task complicated by the elusive role of evolution in these phenotypes. To gain more insights, we combined methods of genome-wide and candidate-gene studies. ... Full text Cite

Resistance to stresses and reliability of biological systems: Insights for genetic studies of human aging, health, and longevity

Conference Proceedings - 2nd International Symposium on Stochastic Models in Reliability Engineering, Life Science, and Operations Management, SMRLO 2016 · March 11, 2016 Connection between stress resistance and longevity in biological organisms is widely discussed and confirmed experimentally. Much less is known about the roles of genetic and non-genetic factors in regulation of such connection. Earlier studies emphasized ... Full text Open Access Cite

Puzzling role of genetic risk factors in human longevity: "risk alleles" as pro-longevity variants.

Journal Article Biogerontology · February 2016 Complex diseases are major contributors to human mortality in old age. Paradoxically, many genetic variants that have been associated with increased risks of such diseases are found in genomes of long-lived people, and do not seem to compromise longevity. ... Full text Open Access Cite

How the effects of aging and stresses of life are integrated in mortality rates: insights for genetic studies of human health and longevity.

Journal Article Biogerontology · February 2016 Increasing proportions of elderly individuals in developed countries combined with substantial increases in related medical expenditures make the improvement of the health of the elderly a high priority today. If the process of aging by individuals is a ma ... Full text Open Access Cite

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).

Other Autophagy · 2016 Full text Open Access Link to item Cite

How Genes Modulate Patterns of Aging-Related Changes on the Way to 100: Biodemographic Models and Methods in Genetic Analyses of Longitudinal Data.

Journal Article North American actuarial journal : NAAJ · January 2016 Background and objectiveTo clarify mechanisms of genetic regulation of human aging and longevity traits, a number of genome-wide association studies (GWAS) of these traits have been performed. However, the results of these analyses did not meet ex ... Full text Open Access Cite

Patterns of Aging Changes in Bodyweight May Predict Alzheimer's Disease.

How are APOE4, changes in body weight, and longevity related? Insights from a causal mediation analysis.

Interactions between genes involved in physiological dysregulation and axon guidance: role in Alzheimer's disease.

Interplay between stress-related genes may influence Alzheimer's disease development: The results of genetic interaction analyses of human data.

Interactions Between Genes From Aging Pathways May Influence Human Lifespan and Improve Animal to Human Translation.

Roles of interacting stress-related genes in lifespan regulation: insights for translating experimental findings to humans.

Genetics of physiological dysregulation: findings from the long life family study using joint models.

Composite Measure of Physiological Dysregulation as a Predictor of Mortality: The Long Life Family Study.

Genetics of Human Longevity From Incomplete Data: New Findings From the Long Life Family Study.

Hidden heterogeneity in Alzheimer's disease: Insights from genetic association studies and other analyses.

How Well Does the Family Longevity Selection Score Work: A Validation Test Using the Utah Population Database.

Uncoupling associations of risk alleles with endophenotypes and phenotypes: insights from the ApoB locus and heart-related traits.

Criteria to assess potential reverse innovations: opportunities for shared learning between high- and low-income countries.

Protective role of the apolipoprotein E2 allele in age-related disease traits and survival: evidence from the Long Life Family Study.

Pleiotropic Associations of Allelic Variants in a 2q22 Region with Risks of Major Human Diseases and Mortality.

Resistance to stresses and reliability of biological systems: Insights for genetic studies of human aging, health, and longevity

Puzzling role of genetic risk factors in human longevity: "risk alleles" as pro-longevity variants.

How the effects of aging and stresses of life are integrated in mortality rates: insights for genetic studies of human health and longevity.

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).

Other Autophagy · 2016 Full text Open Access Link to item Cite

How Genes Modulate Patterns of Aging-Related Changes on the Way to 100: Biodemographic Models and Methods in Genetic Analyses of Longitudinal Data.

Pure and Confounded Effects of Causal SNPs on Longevity: Insights for Proper Interpretation of Research Findings in GWAS of Populations with Different Genetic Structures.

Journal Article Frontiers in genetics · January 2016 This paper shows that the effects of causal SNPs on lifespan, estimated through GWAS, may be confounded and the genetic structure of the study population may be responsible for this effect. Simulation experiments show that levels of linkage disequilibrium ... Full text Open Access Cite

Dynamic Characteristics of Aging-Related Changes as Predictors of Longevity and Healthy Lifespan

Chapter · January 1, 2016 It is well known from epidemiological research that values of indices describing physiological states at a given age may influence human morbidity and mortality risks. Studies of the connections between aging and life span suggest that the dynamic properti ... Full text Cite

On Approaches to Improve Power in Analyses of Genetic Effects on Time-To-Event Outcomes in Longitudinal Studies

Conference GENETIC EPIDEMIOLOGY · November 1, 2015 Link to item Cite

Genetics of aging, health, and survival: dynamic regulation of human longevity related traits.

Journal Article Frontiers in genetics · January 2015 BackgroundThe roles of genetic factors in human longevity would be better understood if one can use more efficient methods in genetic analyses and investigate pleiotropic effects of genetic variants on aging and health related traits.Data and ... Full text Open Access Cite

Birth Cohort, Age, and Sex Strongly Modulate Effects of Lipid Risk Alleles Identified in Genome-Wide Association Studies.

Journal Article PloS one · January 2015 Insights into genetic origin of diseases and related traits could substantially impact strategies for improving human health. The results of genome-wide association studies (GWAS) are often positioned as discoveries of unconditional risk alleles of complex ... Full text Open Access Cite

Genetic Structures of Population Cohorts Change with Increasing Age: Implications for Genetic Analyses of Human aging and Life Span.

Journal Article Annals of gerontology and geriatric research · January 2014 BackgroundCorrecting for the potential effects of population stratification is an important issue in genome wide association studies (GWAS) of complex traits. Principal component analysis (PCA) of the genetic structure of the population under stud ... Open Access Cite

Predicting longevity in C. elegans: fertility, mobility and gene expression.

Journal Article Mechanisms of ageing and development · July 2013 Expression level of an hsp-16.2::gfp transgene is a predictor of longevity in Caenorhabditis elegans. Here we examine fertility, movement and longevity, comparing high-expressing ("bright") and low-expressing ("dim") animals. There was no differential fert ... Full text Cite

How lifespan associated genes modulate aging changes: lessons from analysis of longitudinal data.

Journal Article Frontiers in genetics · January 2013 Background and objectiveThe influence of genes on human lifespan is mediated by biological processes that characterize body's functioning. The age trajectories of these processes contain important information about mechanisms linking aging, health ... Full text Open Access Cite

Why does melanoma metastasize into the brain? Genes with pleiotropic effects might be the key.

Journal Article Frontiers in genetics · January 2013 Full text Open Access Cite

How the quality of GWAS of human lifespan and health span can be improved.

Journal Article Frontiers in genetics · January 2013 Full text Open Access Cite

Relationship Between the APOE Polymorphism and Risks of Cancer and Alzheimer's Disease: Application of the Genetic Stochastic Process Model

Conference GENETIC EPIDEMIOLOGY · November 1, 2012 Link to item Cite

Fertility/longevity trade-offs under limiting-male conditions in mating populations of Caenorhabditis elegans.

Journal Article Experimental gerontology · October 2012 Evolutionary theories of aging suggest that trade-offs between longevity and fitness should be found under certain conditions. In C. elegans, there is little evidence for the existence of such trade-offs. We asked if fertility/longevity trade-offs exist in ... Full text Cite

How genes influence life span: the biodemography of human survival.

Journal Article Rejuvenation research · August 2012 BackgroundIn genome-wide association studies (GWAS) of human life span, none of the genetic variants has reached the level of genome-wide statistical significance. The roles of such variants in life span regulation remain unclear.Data and meth ... Full text Open Access Cite

Polygenic effects of common single-nucleotide polymorphisms on life span: when association meets causality.

Journal Article Rejuvenation research · August 2012 Recently we have shown that the human life span is influenced jointly by many common single-nucleotide polymorphisms (SNPs), each with a small individual effect. Here we investigate further the polygenic influence on life span and discuss its possible biol ... Full text Open Access Cite

Trade-Off In The Effects Of The APOE Polymorphism On The Ages At Onset Of CVD And Cancer: Insights From The Genetic Stochastic Process Model

Conference GENETIC EPIDEMIOLOGY · February 1, 2012 Link to item Cite

Genetic dissection of late-life fertility in Caenorhabditis elegans.

Journal Article The journals of gerontology. Series A, Biological sciences and medical sciences · August 2011 The large post-reproductive life span reported for the free-living hermaphroditic nematode, Caenorhabditis elegans, which lives for about 10 days after its 5-day period of self-reproduction, seems at odds with evolutionary theory. Species with long post-re ... Full text Cite

Trade-off in the effects of the apolipoprotein E polymorphism on the ages at onset of CVD and cancer influences human lifespan.

Journal Article Aging cell · June 2011 Progress in unraveling the genetic origins of healthy aging is tempered, in part, by a lack of replication of effects, which is often considered a signature of false-positive findings. We convincingly demonstrate that the lack of genetic effects on an agin ... Full text Open Access Cite

Joint influence of small-effect genetic variants on human longevity.

Journal Article Aging · September 2010 The results of genome-wide association studies of complex traits, such as life span or age at onset of chronic disease, suggest that such traits are typically affected by a large number of small-effect alleles. Individually such alleles have little predict ... Full text Open Access Cite

Dynamic determinants of longevity and exceptional health.

Journal Article Curr Gerontol Geriatr Res · 2010 It is well known from epidemiology that values of indices describing physiological state in a given age may influence human morbidity and mortality risks. Studies of connection between aging and life span suggest a possibility that dynamic properties of ag ... Full text Link to item Cite

Mortality shifts in Caenorhabditis elegans: remembrance of conditions past.

Journal Article Aging cell · December 2009 The analysis of age-specific mortality can yield insights into how anti-aging interventions operate that cannot be matched by simple assessment of longevity. Mortality, as opposed to longevity, can be used to assess the effects of an anti-aging interventio ... Full text Cite

Multiple mild heat-shocks decrease the Gompertz component of mortality in Caenorhabditis elegans.

Journal Article Experimental gerontology · September 2009 Exposure to mild heat-stress (heat-shock) can significantly increase the life expectancy of the nematode Caenorhabditis elegans. A single heat-shock early in life extends longevity by 20% or more and affects life-long mortality by decreasing initial mortal ... Full text Cite

The U-shaped response of initial mortality in Caenorhabditis elegans to mild heat shock: does it explain recent trends in human mortality?

Journal Article The journals of gerontology. Series A, Biological sciences and medical sciences · July 2008 U-shaped dose-response relationships (hormesis) have been documented in numerous biological, toxicological, and pharmacological investigations. For example, in response to a mild 35 degrees C heat shock, the longevity of Caenorhabditis elegans exhibits an ... Full text Cite

Visualizing hidden heterogeneity in isogenic populations of C. elegans.

Journal Article Experimental gerontology · March 2006 Age-specific mortality levels off at advanced ages in many species; one explanation for this phenomenon is provided by the population heterogeneity theory. Although mortality at advanced ages can be well fit by heterogeneity models, population heterogeneit ... Full text Cite

A stress-sensitive reporter predicts longevity in isogenic populations of Caenorhabditis elegans.

Journal Article Nature genetics · August 2005 When both genotype and environment are held constant, 'chance' variation in the lifespan of individuals in a population is still quite large. Using isogenic populations of the nematode Caenorhabditis elegans, we show that, on the first day of adult life, c ... Full text Cite

Age-specific demographic profiles of longevity mutants in Caenorhabditis elegans show segmental effects.

Journal Article The journals of gerontology. Series A, Biological sciences and medical sciences · August 2001 Demographic profiles of several single-gene longevity mutants of the nematode Caenorhabditis elegans reveal segmental (age-specific) effects on mortality. The mortality profiles of wild-type worms were examined across multiple replicate cultures containing ... Full text Cite

Reproductive potential predicts longevity of female Mediterranean fruitflies.

Journal Article Proceedings. Biological sciences · March 2001 Reproduction exacts a price in terms of decreased survival. Our analysis of the interplay between age patterns of fecundity and mortality for individual female medflies (Ceratitis capitata) revealed that individual mortality is associated with the time-dyn ... Full text Cite

Regional analysis of divorce in China since 1980.

Journal Article Demography · May 2000 This paper estimates and discusses divorce measures in China and its 30 provinces since 1980. The propensity for divorce in China increased 42% between 1982 and 1990. Substantial increases in divorce were observed in all provinces except Xinjiang and Shanx ... Link to item Cite