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Khoi Duc Than

Professor of Neurosurgery
Neurosurgery

Selected Publications


Comparison of intraoperative and postoperative outcomes between open, wiltse, and percutaneous approach to traumatic thoracolumbar spine fractures without neurological injury: A systematic review and meta-analysis.

Journal Article N Am Spine Soc J · December 2024 BACKGROUND: Traumatic thoracolumbar fracture fixation without neurological injury can be performed using the traditional open, mini-open Wiltse, and percutaneous approaches. This systematic review and meta-analysis aims to compare perioperative outcomes be ... Full text Link to item Cite

The T4-L1-Hip Axis: Sagittal Spinal Realignment Targets in Long-Construct Adult Spinal Deformity Surgery: Early Impact.

Journal Article J Bone Joint Surg Am · September 18, 2024 BACKGROUND: Our understanding of the relationship between sagittal alignment and mechanical complications is evolving. In normal spines, the L1-pelvic angle (L1PA) accounts for the magnitude and distribution of lordosis and is strongly associated with pelv ... Full text Link to item Cite

Comparing posterior cervical foraminotomy with anterior cervical discectomy and fusion in radiculopathic patients: an analysis from the Quality Outcomes Database.

Conference J Neurosurg Spine · July 1, 2024 OBJECTIVE: The objective of this study was to compare clinical and patient-reported outcomes (PROs) between posterior foraminotomy and anterior cervical discectomy and fusion (ACDF) in patients presenting with cervical radiculopathy. METHODS: The Quality O ... Full text Link to item Cite

Nationwide Analysis of Risk Factors Related to Opioid Weaning Following Lumbar Decompression Surgery - A Retrospective Database Study.

Journal Article World Neurosurg · June 2024 BACKGROUND: Opioids are often prescribed for patients who eventually undergo lumbar decompression. Given the potential for opioid-related morbidity and mortality, postoperative weaning is often a goal of surgery. The purpose of this study was to examine th ... Full text Link to item Cite

Assessing the Accessibility, Engagement, and Value of the Virtual Global Spine Conference as an Educational Platform for Spine: A Three-Year Review.

Journal Article World Neurosurg · May 2024 INTRODUCTION: The Coronavirus disease 2019 pandemic ushered a paradigm shift in medical education, accelerating the transition to virtual learning in select cases. The Virtual Global Spine Conference (VGSC), launched at the height of the pandemic, is a tes ... Full text Link to item Cite

Early Experience with Prone Lateral Interbody Fusion in Deformity Correction: A Single-Institution Experience.

Journal Article J Clin Med · April 15, 2024 Background/Objectives: Lateral spine surgery offers effective minimally invasive deformity correction, but traditional approaches often involve separate anterior, lateral, and posterior procedures. The prone lateral technique streamlines this process by al ... Full text Open Access Link to item Cite

What predicts the best 24-month outcomes following surgery for cervical spondylotic myelopathy? A QOD prospective registry study.

Journal Article J Neurosurg Spine · April 1, 2024 OBJECTIVE: The aim of this study was to identify predictors of the best 24-month improvements in patients undergoing surgery for cervical spondylotic myelopathy (CSM). For this purpose, the authors leveraged a large prospective cohort of surgically treated ... Full text Open Access Link to item Cite

Predictors of pelvic tilt normalization: a multicenter study on the impact of regional and lower-extremity compensation on pelvic alignment after complex adult spinal deformity surgery.

Journal Article J Neurosurg Spine · April 1, 2024 OBJECTIVE: The objective was to determine the degree of regional decompensation to pelvic tilt (PT) normalization after complex adult spinal deformity (ASD) surgery. METHODS: Operative ASD patients with 1 year of PT measurements were included. Patients wit ... Full text Open Access Link to item Cite

Does the number of social factors affect long-term patient-reported outcomes and satisfaction in those with cervical myelopathy? A QOD study.

Journal Article J Neurosurg Spine · April 1, 2024 OBJECTIVE: It is not clear whether there is an additive effect of social factors in keeping patients with cervical spondylotic myelopathy (CSM) from achieving both a minimum clinically important difference (MCID) in outcomes and satisfaction after surgery. ... Full text Open Access Link to item Cite

Does diabetes affect outcome or reoperation rate after lumbar decompression or arthrodesis? A matched analysis of the Quality Outcomes Database data set.

Journal Article J Neurosurg Spine · March 1, 2024 OBJECTIVE: Diabetes mellitus (DM) is a known risk factor for postsurgical and systemic complications after lumbar spinal surgery. Smaller studies have also demonstrated diminished improvements in patient-reported outcomes (PROs), with increased reoperation ... Full text Open Access Link to item Cite

Advancing Prone-Transpsoas Spine Surgery: A Narrative Review and Evolution of Indications with Representative Cases.

Journal Article J Clin Med · February 16, 2024 The Prone Transpsoas (PTP) approach to lumbar spine surgery, emerging as an evolution of lateral lumbar interbody fusion (LLIF), offers significant advantages over traditional methods. PTP has demonstrated increased lumbar lordosis gains compared to LLIF, ... Full text Open Access Link to item Cite

What factors influence surgical decision-making in anterior versus posterior surgery for cervical myelopathy? A QOD analysis.

Journal Article J Neurosurg Spine · February 1, 2024 OBJECTIVE: The aim of this study was to explore the preoperative patient characteristics that affect surgical decision-making when selecting an anterior or posterior operative approach in patients diagnosed with cervical spondylotic myelopathy (CSM). METHO ... Full text Open Access Link to item Cite

Osteoimmunology: Interactions With the Immune System in Spinal Fusion.

Journal Article Int J Spine Surg · December 27, 2023 Spinal fusion is important for the clinical success of patients undergoing surgery, and the immune system plays an increasingly recognized role. Osteoimmunology is the study of the interactions between the immune system and bone. Inflammation impacts the o ... Full text Open Access Link to item Cite

Clinical and Radiographic Outcomes for Patients with Cervical Adjacent Segment Disease Treated with Anterior Cervical Discectomy and Fusion with Integrated Interbody Spacers.

Journal Article World Neurosurg · December 2023 INTRODUCTION: Anterior cervical discectomy and fusion (ACDF) is among the most common spine procedures. Adjacent segment disease (ASD), characterized by degenerative disease at an adjacent spinal level to a prior fusion, is a well-recognized and significan ... Full text Open Access Link to item Cite

Screw Insertional Torque Measurement in Spine Surgery: Correlation With Bone Mineral Density and Hounsfield Unit.

Journal Article Neurospine · December 2023 OBJECTIVE: Achieving successful fusion during spine surgery is dependent on rigid pedicle screw fixation. To assess fixation strength, the insertional torque can be measured during intraoperative screw fixation. This study aimed to explore the technical fe ... Full text Link to item Cite

Measuring Outcomes in Spinal Deformity Surgery.

Journal Article Neurosurg Clin N Am · October 2023 Outcome assessment in adult spinal deformity has evolved from radiographic analysis of curve correction to patient-centered perception of health-related quality-of-life. Oswestry Disability Index and the Scoliosis Research Society-22 Patient Questionnaire ... Full text Open Access Link to item Cite

Surgical technique of combined minimally invasive anterior column realignment at L1-L2 with open extension of prior fusion.

Journal Article J Spine Surg · September 22, 2023 Surgical correction of fixed kyphotic deformity or severe sagittal imbalance traditionally involves three column osteotomies, which are associated with high morbidity rates. Anterior column realignment (ACR) has emerged as a minimally invasive alternative ... Full text Open Access Link to item Cite

Demographics, Mechanism of Injury, and Outcomes for Acute Upper and Lower Cervical Spinal Cord Injuries: An Analysis of 470 Patients in the Prospective, Multi-Center, North American Clinical Trials Network Registry.

Journal Article J Neurotrauma · September 2023 There is a paucity of data comparing the demographics, mechanism of injury, and outcomes of upper versus lower cervical spinal cord injuries (cSCI). The study objective was to define different clinical manifestations of cSCI. Data were collected prospectiv ... Full text Open Access Link to item Cite

Comparison of intraoperative and postoperative outcomes between open, wiltse, and percutaneous approach to traumatic thoracolumbar spine fractures without neurological injury: A systematic review and meta-analysis.

Journal Article N Am Spine Soc J · December 2024 BACKGROUND: Traumatic thoracolumbar fracture fixation without neurological injury can be performed using the traditional open, mini-open Wiltse, and percutaneous approaches. This systematic review and meta-analysis aims to compare perioperative outcomes be ... Full text Link to item Cite

The T4-L1-Hip Axis: Sagittal Spinal Realignment Targets in Long-Construct Adult Spinal Deformity Surgery: Early Impact.

Journal Article J Bone Joint Surg Am · September 18, 2024 BACKGROUND: Our understanding of the relationship between sagittal alignment and mechanical complications is evolving. In normal spines, the L1-pelvic angle (L1PA) accounts for the magnitude and distribution of lordosis and is strongly associated with pelv ... Full text Link to item Cite

Comparing posterior cervical foraminotomy with anterior cervical discectomy and fusion in radiculopathic patients: an analysis from the Quality Outcomes Database.

Conference J Neurosurg Spine · July 1, 2024 OBJECTIVE: The objective of this study was to compare clinical and patient-reported outcomes (PROs) between posterior foraminotomy and anterior cervical discectomy and fusion (ACDF) in patients presenting with cervical radiculopathy. METHODS: The Quality O ... Full text Link to item Cite

Nationwide Analysis of Risk Factors Related to Opioid Weaning Following Lumbar Decompression Surgery - A Retrospective Database Study.

Journal Article World Neurosurg · June 2024 BACKGROUND: Opioids are often prescribed for patients who eventually undergo lumbar decompression. Given the potential for opioid-related morbidity and mortality, postoperative weaning is often a goal of surgery. The purpose of this study was to examine th ... Full text Link to item Cite

Assessing the Accessibility, Engagement, and Value of the Virtual Global Spine Conference as an Educational Platform for Spine: A Three-Year Review.

Journal Article World Neurosurg · May 2024 INTRODUCTION: The Coronavirus disease 2019 pandemic ushered a paradigm shift in medical education, accelerating the transition to virtual learning in select cases. The Virtual Global Spine Conference (VGSC), launched at the height of the pandemic, is a tes ... Full text Link to item Cite

Early Experience with Prone Lateral Interbody Fusion in Deformity Correction: A Single-Institution Experience.

Journal Article J Clin Med · April 15, 2024 Background/Objectives: Lateral spine surgery offers effective minimally invasive deformity correction, but traditional approaches often involve separate anterior, lateral, and posterior procedures. The prone lateral technique streamlines this process by al ... Full text Open Access Link to item Cite

What predicts the best 24-month outcomes following surgery for cervical spondylotic myelopathy? A QOD prospective registry study.

Journal Article J Neurosurg Spine · April 1, 2024 OBJECTIVE: The aim of this study was to identify predictors of the best 24-month improvements in patients undergoing surgery for cervical spondylotic myelopathy (CSM). For this purpose, the authors leveraged a large prospective cohort of surgically treated ... Full text Open Access Link to item Cite

Predictors of pelvic tilt normalization: a multicenter study on the impact of regional and lower-extremity compensation on pelvic alignment after complex adult spinal deformity surgery.

Journal Article J Neurosurg Spine · April 1, 2024 OBJECTIVE: The objective was to determine the degree of regional decompensation to pelvic tilt (PT) normalization after complex adult spinal deformity (ASD) surgery. METHODS: Operative ASD patients with 1 year of PT measurements were included. Patients wit ... Full text Open Access Link to item Cite

Does the number of social factors affect long-term patient-reported outcomes and satisfaction in those with cervical myelopathy? A QOD study.

Journal Article J Neurosurg Spine · April 1, 2024 OBJECTIVE: It is not clear whether there is an additive effect of social factors in keeping patients with cervical spondylotic myelopathy (CSM) from achieving both a minimum clinically important difference (MCID) in outcomes and satisfaction after surgery. ... Full text Open Access Link to item Cite

Does diabetes affect outcome or reoperation rate after lumbar decompression or arthrodesis? A matched analysis of the Quality Outcomes Database data set.

Journal Article J Neurosurg Spine · March 1, 2024 OBJECTIVE: Diabetes mellitus (DM) is a known risk factor for postsurgical and systemic complications after lumbar spinal surgery. Smaller studies have also demonstrated diminished improvements in patient-reported outcomes (PROs), with increased reoperation ... Full text Open Access Link to item Cite

Advancing Prone-Transpsoas Spine Surgery: A Narrative Review and Evolution of Indications with Representative Cases.

Journal Article J Clin Med · February 16, 2024 The Prone Transpsoas (PTP) approach to lumbar spine surgery, emerging as an evolution of lateral lumbar interbody fusion (LLIF), offers significant advantages over traditional methods. PTP has demonstrated increased lumbar lordosis gains compared to LLIF, ... Full text Open Access Link to item Cite

What factors influence surgical decision-making in anterior versus posterior surgery for cervical myelopathy? A QOD analysis.

Journal Article J Neurosurg Spine · February 1, 2024 OBJECTIVE: The aim of this study was to explore the preoperative patient characteristics that affect surgical decision-making when selecting an anterior or posterior operative approach in patients diagnosed with cervical spondylotic myelopathy (CSM). METHO ... Full text Open Access Link to item Cite

Osteoimmunology: Interactions With the Immune System in Spinal Fusion.

Journal Article Int J Spine Surg · December 27, 2023 Spinal fusion is important for the clinical success of patients undergoing surgery, and the immune system plays an increasingly recognized role. Osteoimmunology is the study of the interactions between the immune system and bone. Inflammation impacts the o ... Full text Open Access Link to item Cite

Clinical and Radiographic Outcomes for Patients with Cervical Adjacent Segment Disease Treated with Anterior Cervical Discectomy and Fusion with Integrated Interbody Spacers.

Journal Article World Neurosurg · December 2023 INTRODUCTION: Anterior cervical discectomy and fusion (ACDF) is among the most common spine procedures. Adjacent segment disease (ASD), characterized by degenerative disease at an adjacent spinal level to a prior fusion, is a well-recognized and significan ... Full text Open Access Link to item Cite

Screw Insertional Torque Measurement in Spine Surgery: Correlation With Bone Mineral Density and Hounsfield Unit.

Journal Article Neurospine · December 2023 OBJECTIVE: Achieving successful fusion during spine surgery is dependent on rigid pedicle screw fixation. To assess fixation strength, the insertional torque can be measured during intraoperative screw fixation. This study aimed to explore the technical fe ... Full text Link to item Cite

Measuring Outcomes in Spinal Deformity Surgery.

Journal Article Neurosurg Clin N Am · October 2023 Outcome assessment in adult spinal deformity has evolved from radiographic analysis of curve correction to patient-centered perception of health-related quality-of-life. Oswestry Disability Index and the Scoliosis Research Society-22 Patient Questionnaire ... Full text Open Access Link to item Cite

Surgical technique of combined minimally invasive anterior column realignment at L1-L2 with open extension of prior fusion.

Journal Article J Spine Surg · September 22, 2023 Surgical correction of fixed kyphotic deformity or severe sagittal imbalance traditionally involves three column osteotomies, which are associated with high morbidity rates. Anterior column realignment (ACR) has emerged as a minimally invasive alternative ... Full text Open Access Link to item Cite

Demographics, Mechanism of Injury, and Outcomes for Acute Upper and Lower Cervical Spinal Cord Injuries: An Analysis of 470 Patients in the Prospective, Multi-Center, North American Clinical Trials Network Registry.

Journal Article J Neurotrauma · September 2023 There is a paucity of data comparing the demographics, mechanism of injury, and outcomes of upper versus lower cervical spinal cord injuries (cSCI). The study objective was to define different clinical manifestations of cSCI. Data were collected prospectiv ... Full text Open Access Link to item Cite

Incremental benefits of circumferential minimally invasive surgery for increasingly frail patients with adult spinal deformity.

Journal Article J Neurosurg Spine · August 1, 2023 OBJECTIVE: Circumferential minimally invasive surgery (cMIS) may provide incremental benefits compared with open surgery for patients with increasing frailty status by decreasing peri- and postoperative complications. METHODS: Operative patients with adult ... Full text Open Access Link to item Cite

Clinical Outcomes and Cost Profiles for Cage and Allograft Anterior Cervical Discectomy and Fusion Procedures in the Adult Population: A Propensity Score-Matched Study.

Journal Article Asian Spine J · August 2023 STUDY DESIGN: Retrospective cohort study. PURPOSE: To characterize the postoperative outcomes and economic costs of anterior cervical discectomy and fusion (ACDF) procedures using synthetic biomechanical intervertebral cage (BC) and structural allograft (S ... Full text Link to item Cite

Do comorbid self-reported depression and anxiety influence outcomes following surgery for cervical spondylotic myelopathy?

Journal Article J Neurosurg Spine · July 1, 2023 OBJECTIVE: Depression and anxiety are associated with inferior outcomes following spine surgery. In this study, the authors examined whether patients with cervical spondylotic myelopathy (CSM) who have both self-reported depression (SRD) and self-reported ... Full text Open Access Link to item Cite

Natural history of adult spinal deformity: how do patients with suboptimal surgical outcomes fare relative to nonoperative counterparts?

Journal Article J Neurosurg Spine · July 1, 2023 OBJECTIVE: Management of adult spinal deformity (ASD) has increasingly favored operative intervention; however, the incidence of complications and reoperations is high, and patients may fail to achieve idealized postsurgical results. This study compared he ... Full text Link to item Cite

Enterothecal fistula as a rare cause of adult pneumocephalus and meningitis: a case report.

Journal Article J Spine Surg · June 30, 2023 BACKGROUND: Enterothecal fistulas are pathological connections between the gastrointestinal system and subarachnoid space. These rare fistulas occur mostly in pediatric patients with sacral developmental anomalies. They have yet to be characterized in an a ... Full text Link to item Cite

Treatment of L5-S1 spondyloptosis with stand-alone anterior lumbar interbody fusion in a patient with neurofibromatosis.

Journal Article Br J Neurosurg · June 2023 BACKGROUND: Neurofibromatosis type 1 (NF1) is a multisystem disorder that causes multiple tumor formations throughout the nervous system. Common spinal dysplasias seen with NF1, such as dural ectasia (DE), often undergo modulation and predispose these pati ... Full text Link to item Cite

Spinal Deformity Complexity Checklist for Minimally Invasive Surgery: Expert Consensus from the Minimally Invasive International Spine Study Group.

Journal Article World Neurosurg · May 2023 BACKGROUND: We developed a spinal deformity complexity checklist (SDCC) to assess the difficulty in performing a circumferential minimally invasive surgery (MIS) for adult spinal deformity. METHODS: A modified Delphi method of panel experts was used to con ... Full text Link to item Cite

How closely are outcome questionnaires correlated to patient satisfaction after cervical spine surgery for myelopathy?

Journal Article J Neurosurg Spine · May 1, 2023 OBJECTIVE: Patient-reported outcomes (PROs) have become the standard means to measure surgical outcomes. Insurers and policy makers are also increasingly utilizing PROs to assess the value of care and measure different aspects of a patient's condition. For ... Full text Open Access Link to item Cite

Characteristics of patients who return to work after undergoing surgery for cervical spondylotic myelopathy: a Quality Outcomes Database study.

Journal Article J Neurosurg Spine · May 1, 2023 OBJECTIVE: Return to work (RTW) is an important surgical outcome for patients who are employed, yet a significant number of patients with cervical spondylotic myelopathy (CSM) who are employed undergo cervical spine surgery and fail to RTW. In this study, ... Full text Open Access Link to item Cite

How Digital Opinion Leaders (DOLs) in Clinical Care are Changing the Medical Landscape.

Journal Article Pharmaceut Med · May 2023 Clinical experts are embracing the use of social media platforms for medical education, outreach, data sharing, and content dissemination within the medical community. In this interview, Dr. Khoi Than, a specialist in minimally invasive spinal surgery expl ... Full text Link to item Cite

A Comparison of Percutaneous Pedicle Screw Accuracy Between Robotic Navigation and Novel Fluoroscopy-Based Instrument Tracking for Patients Undergoing Instrumented Thoracolumbar Surgery.

Journal Article World Neurosurg · April 2023 BACKGROUND: The accuracy of pedicle screws placed with instrument tracking and robotic navigation are individually comparable or superior to placement using standard fluoroscopy, however head-to-head comparisons between these adjuncts in a similar surgical ... Full text Link to item Cite

Sleep Disturbances in Cervical Spondylotic Myelopathy: Prevalence and Postoperative Outcomes-an Analysis From the Quality Outcomes Database.

Journal Article Clin Spine Surg · April 1, 2023 STUDY DESIGN: Prospective observational study, level of evidence 1 for prognostic investigations. OBJECTIVES: To evaluate the prevalence of sleep impairment and predictors of improved sleep quality 24 months postoperatively in cervical spondylotic myelopat ... Full text Open Access Link to item Cite

High-Impact Chronic Pain Transition in Lumbar Surgery Recipients.

Journal Article Pain Med · March 1, 2023 OBJECTIVE: High-impact chronic pain (HICP) is a term that characterizes the presence of a severe and troubling pain-related condition. To date, the prevalence of HICP in lumbar spine surgery recipients and their HICP transitions from before to after surger ... Full text Open Access Link to item Cite

Development of new postoperative neck pain at 12 and 24 months after surgery for cervical spondylotic myelopathy: a Quality Outcomes Database study.

Journal Article J Neurosurg Spine · March 1, 2023 OBJECTIVE: Patients who undergo surgery for cervical spondylotic myelopathy (CSM) will occasionally develop postoperative neck pain that was not present preoperatively, yet the incidence of this phenomenon is unclear. The authors aimed to elucidate patient ... Full text Open Access Link to item Cite

Management of Anticoagulation/Antiplatelet Medication and Venous Thromboembolism Prophylaxis in Elective Spine Surgery: Concise Clinical Recommendations Based on a Modified Delphi Process.

Journal Article Spine (Phila Pa 1976) · March 1, 2023 STUDY DESIGN: Delphi method. OBJECTIVE: To gain consensus on the following questions: (1) When should anticoagulation/antiplatelet (AC/AP) medication be stopped before elective spine surgery?; (2) When should AC/AP medication be restarted after elective sp ... Full text Link to item Cite

Cervical spondylotic myelopathy with severe axial neck pain: is anterior or posterior approach better?

Journal Article J Neurosurg Spine · January 1, 2023 OBJECTIVE: The aim of this study was to determine whether multilevel anterior cervical discectomy and fusion (ACDF) or posterior cervical laminectomy and fusion (PCLF) is superior for patients with cervical spondylotic myelopathy (CSM) and high preoperativ ... Full text Open Access Link to item Cite

Return to work after adult spinal deformity surgery.

Journal Article Spine Deform · January 2023 PURPOSE: To determine the proportions of patients returning to work at various points after adult spinal deformity (ASD) surgery and the associations between surgical invasiveness and time to return to work. METHODS: Using a multicenter database of patient ... Full text Open Access Link to item Cite

Instrument Tracking for Prone Lateral Surgery.

Journal Article World Neurosurg · January 2023 The prone lateral transpsoas approach for lumbar interbody fusion and posterior instrumentation enables a large surface area implant without disruption of the posterior spine musculature from a single position.1,2 The addition of virtual live fluoroscopy i ... Full text Open Access Link to item Cite

How dimensions can guide surgical planning and training: a systematic review of Kambin's triangle.

Journal Article Neurosurg Focus · January 2023 OBJECTIVE: The authors sought to analyze the current literature to determine dimensional trends across the lumbar levels of Kambin's triangle, clarify the role of imaging techniques for preoperative planning, and understand the effect of inclusion of the s ... Full text Link to item Cite

Revision Surgery in the Elderly

Chapter · January 1, 2023 With improvements in health care and life expectancy, the number of elderly patients pursuing spine care is increasing. Compared to younger patients, the elderly population often presents with more comorbidities and natural physiologic changes that occur w ... Full text Cite

Correlation of the Modified Japanese Orthopedic Association With Functional and Quality-of-Life Outcomes After Surgery for Degenerative Cervical Myelopathy: A Quality Outcomes Database Study.

Journal Article Neurosurgery · December 1, 2022 BACKGROUND: The modified Japanese Orthopedic Association (mJOA) score is a widely used and validated metric for assessing severity of myelopathy. Its relationship to functional and quality-of-life outcomes after surgery has not been fully described. OBJECT ... Full text Open Access Link to item Cite

Three-Column Osteotomy in Adult Spinal Deformity: An Analysis of Temporal Trends in Usage and Outcomes.

Journal Article J Bone Joint Surg Am · November 2, 2022 BACKGROUND: Three-column osteotomies (3COs), usually in the form of pedicle subtraction or vertebral column resection, have become common in adult spinal deformity surgery. Although a powerful tool for deformity correction, 3COs can increase the risks of p ... Full text Open Access Link to item Cite

Dr. Ruth Jackson: the legacy of the first female spine surgeon.

Journal Article J Neurosurg Spine · November 1, 2022 Dr. Ruth Jackson, born in 1902, was the first female spine surgeon on record. Her story of remarkable resilience and sacrifice is even more relevant given the stark gender disparities in orthopedic surgery and neurosurgery that remain today. Dr. Jackson en ... Full text Open Access Link to item Cite

Determining the time frame of maximum clinical improvement in surgical decompression for cervical spondylotic myelopathy when stratified by preoperative myelopathy severity: a cervical Quality Outcomes Database study.

Journal Article J Neurosurg Spine · November 1, 2022 OBJECTIVE: While surgical decompression is an important treatment modality for cervical spondylotic myelopathy (CSM), it remains unclear if the severity of preoperative myelopathy status affects potential benefit from surgical intervention and when maximum ... Full text Link to item Cite

Differences in postoperative quality of life in young, early elderly, and late elderly patients undergoing surgical treatment for degenerative cervical myelopathy.

Journal Article J Neurosurg Spine · September 1, 2022 OBJECTIVE: Cervical spondylotic myelopathy (CSM) is a common progressive spine disorder affecting predominantly middle-aged and elderly populations. With increasing life expectancy, the incidence of CSM is expected to rise further. The outcomes of elderly ... Full text Open Access Link to item Cite

Single-position prone transpsoas fusion for the treatment of lumbar adjacent segment disease: early experience of twenty-four cases across three tertiary medical centers.

Journal Article Eur Spine J · September 2022 PURPOSE: Prone transpsoas fusion (PTP) is a minimally invasive technique that maximizes the benefit of lateral access interbody surgery and the prone positioning for surgically significant adjacent segment disease. The authors describe the feasibility, rep ... Full text Open Access Link to item Cite

Role of obesity in less radiographic correction and worse health-related quality-of-life outcomes following minimally invasive deformity surgery.

Journal Article J Neurosurg Spine · August 1, 2022 OBJECTIVE: Minimally invasive surgery (MIS) for adult spinal deformity (ASD) can offer deformity correction with less tissue manipulation and damage. However, the impact of obesity on clinical outcomes and radiographic correction following MIS for ASD is p ... Full text Open Access Link to item Cite

Rates of Loosening, Failure, and Revision of Iliac Fixation in Adult Deformity Surgery.

Journal Article Spine (Phila Pa 1976) · July 15, 2022 STUDY DESIGN: Retrospective cohort review of a prospective multicenter database. OBJECTIVE: Identify rates and variations in lumbopelvic fixation failure after adult spinal deformity (ASD) correction. SUMMARY OF BACKGROUND DATA: Traditional iliac (IS) and ... Full text Open Access Link to item Cite

High-impact chronic pain transition in surgical recipients with cervical spondylotic myelopathy.

Journal Article J Neurosurg Spine · July 1, 2022 OBJECTIVE: High-impact chronic pain (HICP) is a recently proposed metric that indicates the presence of a severe and troubling pain-related condition. Surgery for cervical spondylotic myelopathy (CSM) is designed to halt disease transition independent of c ... Full text Open Access Link to item Cite

Social risk factors predicting outcomes of cervical myelopathy surgery.

Journal Article J Neurosurg Spine · July 1, 2022 OBJECTIVE: Combinations of certain social risk factors of race, sex, education, socioeconomic status (SES), insurance, education, employment, and one's housing situation have been associated with poorer pain and disability outcomes after lumbar spine surge ... Full text Open Access Link to item Cite

Sacroiliac Joint Fusion Using Robotic Navigation: Technical Note and Case Series.

Conference Oper Neurosurg (Hagerstown) · July 1, 2022 BACKGROUND: Patients undergoing sacroiliac (SI) fusion can oftentimes experience significant improvements in pain and quality of life. OBJECTIVE: To describe a novel application of robotic navigation to assist with minimally invasive SI joint fusion. METHO ... Full text Link to item Cite

Utility of Virtual Spine Neurosurgery Education for Medical Students.

Journal Article World Neurosurg · July 2022 OBJECTIVE: Distance learning has become increasingly important to expand access to neurosurgical spine education. However, emerging online spine education initiatives have largely focused on residents, fellows, and surgeons in practice. We aimed to assess ... Full text Link to item Cite

Minimally invasive lateral retroperitoneal transpsoas approach for lumbar corpectomy and fusion with posterior instrumentation.

Journal Article Neurosurg Focus Video · July 2022 In this video, the authors highlight the operative treatment of a 55-year-old man with chronic osteomyelitis discitis. The operation entailed a minimally invasive lateral retroperitoneal transpsoas approach for L3 and L4 corpectomies, L2-5 interbody fusion ... Full text Open Access Link to item Cite

Perioperative Pain Management for Elective Spine Surgery: Opioid Use and Multimodal Strategies.

Journal Article World Neurosurg · June 2022 In recent years, physicians and institutions have come to recognize the increasing opioid epidemic in the United States, thus prompting a dramatic shift in opioid prescribing patterns. The lack of well-studied alternative treatment regimens has led to a su ... Full text Open Access Link to item Cite

Prospective multicenter study of minimally invasive surgery for the treatment of adult spinal deformity

Journal Article Journal of Neurosurgery: Spine · May 1, 2022 OBJECTIVE Traditional surgery for adult spinal deformity (ASD) is effective but may result in exposure-related morbidity. Minimally invasive surgery (MIS) can potentially minimize this morbidity; however, high-level evidence is lacking. This study presents ... Full text Cite

An updated management algorithm for incorporating minimally invasive techniques to treat thoracolumbar trauma.

Journal Article J Neurosurg Spine · April 1, 2022 OBJECTIVE: Minimally invasive surgery (MIS) techniques can effectively stabilize and decompress many thoracolumbar injuries with decreased morbidity and tissue destruction compared with open approaches. Nonetheless, there is limited direction regarding the ... Full text Link to item Cite

Two- and three-year outcomes of minimally invasive and hybrid correction of adult spinal deformity.

Journal Article J Neurosurg Spine · April 1, 2022 OBJECTIVE: Previous studies have demonstrated the short-term radiographic and clinical benefits of circumferential minimally invasive surgery (cMIS) and hybrid (i.e., minimally invasive anterior or lateral interbody fusion with an open posterior approach) ... Full text Open Access Link to item Cite

Association of ≥ 12 months of delayed surgical treatment for cervical myelopathy with worsened postoperative outcomes: a multicenter analysis of the Quality Outcomes Database.

Journal Article J Neurosurg Spine · April 1, 2022 OBJECTIVE: Degenerative cervical myelopathy (DCM) results in significant morbidity. The duration of symptoms prior to surgical intervention may be associated with postoperative surgical outcomes and functional recovery. The authors' objective was to invest ... Full text Link to item Cite

Patient outcomes after circumferential minimally invasive surgery compared with those of open correction for adult spinal deformity: initial analysis of prospectively collected data.

Journal Article J Neurosurg Spine · February 1, 2022 OBJECTIVE: Circumferential minimally invasive spine surgery (cMIS) for adult scoliosis has become more advanced and powerful, but direct comparison with traditional open correction using prospectively collected data is limited. The authors performed a retr ... Full text Open Access Link to item Cite

Posterior Cervical Decompression and Fusion With Exoscope: 2-Dimensional Operative Video.

Journal Article Oper Neurosurg (Hagerstown) · February 1, 2022 Posterior cervical decompression and fusion is an effective strategy for correction of cervical spondylotic myelopathy. Here, we highlight the operative treatment of a 63-yr-old man entailing a 4-level posterior cervical laminectomy and fusion, with the us ... Full text Open Access Link to item Cite

Beyond Placement of Pedicle Screws - New Applications for Robotics in Spine Surgery: A Multi-Surgeon, Single-Institution Experience.

Journal Article Front Surg · 2022 Interest in robotic-assisted spine surgery has grown as surgeon comfort and technology has evolved to maximize benefits of time saving and precision. However, the Food and Drug Administration (FDA) has currently only approved robotics to assist in determin ... Full text Open Access Link to item Cite

A New Job: A Steep Learning Curve

Chapter · January 1, 2022 In this chapter, Dr. Than discusses the journey of finding a new job and ensuring that the position is the right fit for you. Do not start the job search too early. For academics, 1 year ahead of time is the sweet spot. Cast a wide net. The most common res ... Full text Cite

Robotic navigation in spine surgery: Where are we now and where are we going?

Journal Article J Clin Neurosci · December 2021 Robotic navigation is a new and rapidly emerging niche within minimally invasive spine surgery. The robotic arms-race began in 2004 and has resulted in no less than four major robotic surgical adjuncts. Current Food and Drug Administration (FDA)-approved a ... Full text Link to item Cite

Robotic-Assisted Trajectory Into Kambin's Triangle During Percutaneous Transforaminal Lumbar Interbody Fusion-Initial Case Series Investigating Safety and Efficacy.

Journal Article Oper Neurosurg (Hagerstown) · November 15, 2021 BACKGROUND: Minimally invasive spine surgery (MISS) has the potential to further advance with the use of robot-assisted (RA) techniques. While RA pedicle screw placement has been extensively investigated, there is a lack of literature on the use of the rob ... Full text Link to item Cite

Robotic-assisted percutaneous iliac screw fixation for destructive lumbosacral metastatic lesions: an early single-institution experience.

Journal Article Acta Neurochir (Wien) · November 2021 BACKGROUND: Robotic-assisted surgery is becoming more widely applied in surgical subspecialties due to its intraoperative and postoperative advantages such as minimally invasive approach, reduced blood loss, shorter hospital stay, and decreased incidence o ... Full text Link to item Cite

ACR Appropriateness Criteria® Plexopathy: 2021 Update.

Journal Article J Am Coll Radiol · November 2021 Plexopathy may be caused by diverse pathologies, including trauma, nerve entrapment, neoplasm, inflammation, infection, autoimmune disease, hereditary disease, and idiopathic etiologies. For patients presenting with brachial or lumbosacral plexopathy, dedi ... Full text Link to item Cite

Two-Level Minimally Invasive Lumbar Laminectomy and Foraminotomy: 2-Dimensional Operative Video.

Journal Article Oper Neurosurg (Hagerstown) · August 16, 2021 Minimally invasive lumbar laminectomies utilize tubular retractors to minimize tissue disturbance, blood loss, and hospital length of stay compared to open operations. Here, we highlight the operative treatment of a 68-yr-old male entailing a 2-level minim ... Full text Link to item Cite

Front-Back Cervical Deformity Correction by Anterior Cervical Discectomy and Fusion With Posterior Instrumentation: 2-Dimensional Operative Video.

Journal Article Oper Neurosurg (Hagerstown) · August 16, 2021 Front-back procedures for cervical deformity permit the correction of cervical kyphosis in the setting of unfused facets. Here, we highlight the operative treatment of a 65-yr-old female entailing a 4-level anterior cervical discectomy and fusion (ACDF) at ... Full text Open Access Link to item Cite

A Prospective Comparison of the Effects of Instrument Tracking on Time and Radiation During Minimally Invasive Lumbar Interbody Fusion.

Journal Article World Neurosurg · August 2021 BACKGROUND: Minimally invasive surgical techniques have resulted in improved patient outcomes. One drawback has been the increased reliance on fluoroscopy and subsequent exposure to ionizing radiation. We have previously shown the efficacy of a novel instr ... Full text Link to item Cite

Characterization and rate of symptomatic adjacent-segment disease after index lateral lumbar interbody fusion: a single-institution, multisurgeon case series with long-term follow-up.

Journal Article J Neurosurg Spine · August 1, 2021 OBJECTIVE: The rate of symptomatic adjacent-segment disease (ASD) after newer minimally invasive techniques, such as lateral lumbar interbody fusion (LLIF), is not known. This study aimed to assess the incidence of surgically significant ASD in adult patie ... Full text Link to item Cite

Emerging Technologies in Spinal Surgery.

Journal Article Oper Neurosurg (Hagerstown) · June 15, 2021 Full text Link to item Cite

The Impact of Instrumentation and Implant Surface Technology on Cervical and Thoracolumbar Fusion.

Journal Article Oper Neurosurg (Hagerstown) · June 15, 2021 Spinal fusion has undergone significant evolution and improvement over the past 50 yr. Historically, spine fusion was noninstrumented and arthrodesis was based entirely on autograft. Improved understanding of spinal anatomy and materials science ushered in ... Full text Open Access Link to item Cite

Commentary: Osteobiologics.

Journal Article Oper Neurosurg (Hagerstown) · June 15, 2021 Full text Link to item Cite

Commentary: Optimizing Visualization in Endoscopic Spine Surgery.

Journal Article Oper Neurosurg (Hagerstown) · June 15, 2021 Full text Link to item Cite

Patient-related and radiographic predictors of inferior health-related quality-of-life measures in adult patients with nonoperative spinal deformity.

Journal Article J Neurosurg Spine · June 1, 2021 OBJECTIVE: Patients with nonoperative (N-Op) adult spinal deformity (ASD) have inferior long-term spinopelvic alignment and clinical outcomes. Predictors of lower quality-of-life measures in N-Op populations have yet to be sufficiently investigated. The ai ... Full text Open Access Link to item Cite

Pseudarthrosis rate following anterior cervical discectomy with fusion using an allograft cellular bone matrix: a multi-institutional analysis.

Journal Article Neurosurg Focus · June 2021 OBJECTIVE: The use of osteobiologics, engineered materials designed to promote bone healing by enhancing bone growth, is becoming increasingly common for spinal fusion procedures, but the efficacy of some of these products is unclear. The authors performed ... Full text Open Access Link to item Cite

The minimally invasive interbody selection algorithm for spinal deformity.

Journal Article J Neurosurg Spine · May 1, 2021 OBJECTIVE: Minimally invasive surgery (MIS) for spinal deformity uses interbody techniques for correction, indirect decompression, and arthrodesis. Selection criteria for choosing a particular interbody approach are lacking. The authors created the minimal ... Full text Open Access Link to item Cite

Interhospital transfer status for spinal metastasis patients in the United States is associated with more severe clinical presentations and higher rates of inpatient complications.

Journal Article Neurosurg Focus · May 2021 OBJECTIVE: In patients with metastatic spinal disease (MSD), interhospital transfer can potentially impact clinical outcomes as the possible benefits of transferring a patient to a higher level of care must be weighed against the negative effects associate ... Full text Open Access Link to item Cite

Revision Surgery Rates After Minimally Invasive Adult Spinal Deformity Surgery: Correlation with Roussouly Spine Type at 2-Year Follow-Up?

Journal Article World Neurosurg · April 2021 BACKGROUND: Spinopelvic parameters have hitherto dictated much of adult spinal deformity (ASD) correction. The Roussouly classification is used for the normal adult spine. We evaluated whether a correlation would be found between the Roussouly type and the ... Full text Link to item Cite

Hematocrit as a predictor of preoperative transfusion-associated complications in spine surgery: A NSQIP study.

Journal Article Clin Neurol Neurosurg · January 2021 BACKGROUND CONTEXT: Preoperative optimization of medical comorbidities prior to spinal surgery is becoming an increasingly important intervention in decreasing postoperative complications and ensuring a satisfactory postoperative course. The treatment of p ... Full text Open Access Link to item Cite

Biomechanics, evaluation, and management of subaxial cervical spine injuries: A comprehensive review of the literature.

Journal Article J Clin Neurosci · January 2021 STUDY DESIGN: Literature review. OBJECTIVES: It has been reported that 2.4-3.7% of all blunt trauma victims suffer some element of cervical spine fracture, with the majority of these patients suffering from C3-7 (subaxial) involvement. With the improvement ... Full text Open Access Link to item Cite

Management of Acute Traumatic Spinal Cord Injury: A Review of the Literature.

Journal Article Front Surg · 2021 Traumatic spinal cord injury (TSCI) is a debilitating disease that poses significant functional and economic burden on both the individual and societal levels. Prognosis is dependent on the extent of the spinal injury and the severity of neurological dysfu ... Full text Open Access Link to item Cite

Factors affecting approach selection for minimally invasive versus open surgery in the treatment of adult spinal deformity: analysis of a prospective, nonrandomized multicenter study.

Journal Article J Neurosurg Spine · November 1, 2020 OBJECTIVE: Surgical decision-making and planning is a key factor in optimizing outcomes in adult spinal deformity (ASD). Minimally invasive spinal (MIS) strategies for ASD have been increasingly used as an option to decrease postoperative morbidity. This s ... Full text Open Access Link to item Cite

The medicolegal impact of misplaced pedicle and lateral mass screws on spine surgery in the United States.

Journal Article Neurosurg Focus · November 2020 Spine surgery has been disproportionately impacted by medical liability and malpractice litigation, with the majority of claims and payouts related to procedural error. One common area for the potential avoidance of malpractice claims and subsequent payout ... Full text Open Access Link to item Cite

Virtual Spine: A Novel, International Teleconferencing Program Developed to Increase the Accessibility of Spine Education During the COVID-19 Pandemic.

Journal Article World Neurosurg · August 2020 BACKGROUND: The coronavirus identified in 2019 (COVID-19) pandemic effectively ended all major spine educational conferences in the first half of 2020. In response, the authors formed a "virtual" case-based conference series directed at delivering spine ed ... Full text Link to item Cite

Klippel-Feil Syndrome with Cervical Diastematomyelia in an Adult with Extensive Cervicothoracic Fusions: Case Report and Review of the Literature.

Journal Article World Neurosurg · July 2020 Split cord malformation (SCM) is a developmental disorder that is usually symptomatic and diagnosed in childhood. The majority of these lesions are in the thoracic and lumbar spine, with only 1%-3% of cases found in the cervical spine. This is a case repor ... Full text Link to item Cite

Neuroanesthesia Guidelines for Optimizing Transcranial Motor Evoked Potential Neuromonitoring During Deformity and Complex Spinal Surgery: A Delphi Consensus Study.

Journal Article Spine (Phila Pa 1976) · July 1, 2020 STUDY DESIGN: Expert opinion-modified Delphi study. OBJECTIVE: We used a modified Delphi approach to obtain consensus among leading spinal deformity surgeons and their neuroanesthesiology teams regarding optimal practices for obtaining reliable motor evoke ... Full text Open Access Link to item Cite

Awake percutaneous transforaminal lumbar interbody fusion with expandable cage and robotic-assisted navigation and instrumentation: Case report and review of literature

Journal Article Interdisciplinary Neurosurgery: Advanced Techniques and Case Management · June 1, 2020 Awake surgeries are commonly performed in many specialties through the use of local or regional anesthesia. These methods avoid the risks associated with general endotracheal anesthesia and allow faster recovery times. In neurosurgery, awake surgeries are ... Full text Cite

Book Review: Navigation and Robotics in Spine Surgery

Journal Article Neurosurgery · June 2020 Full text Cite

PEEK interbody devices for multilevel anterior cervical discectomy and fusion: association with more than 6-fold higher rates of pseudarthrosis compared to structural allograft.

Journal Article J Neurosurg Spine · May 1, 2020 OBJECTIVE: Common interbody graft options for anterior cervical discectomy and fusion (ACDF) include allograft and polyetheretherketone (PEEK). PEEK has gained popularity due to its radiolucent properties and a modulus of elasticity similar to that of bone ... Full text Link to item Cite

ACR Appropriateness Criteria® Primary Bone Tumors.

Journal Article J Am Coll Radiol · May 2020 Although primary bone tumors are relatively uncommon, appropriate imaging evaluation is essential when they are suspected or incidentally detected. In almost all cases, radiographs are the most appropriate initial imaging study for screening and characteri ... Full text Link to item Cite

Combined magnetic field results in higher fusion rates than pulsed electromagnetic field bone stimulation after thoracolumbar fusion surgery.

Journal Article J Clin Neurosci · April 2020 BACKGROUND: Bone growth stimulators have been used as an adjunct to spinal fusion surgery in efforts to increase fusion rates. METHODS: The authors retrospectively reviewed the medical records of patients who underwent thoracolumbar fusion surgeries by a s ... Full text Link to item Cite

The MISDEF2 algorithm: an updated algorithm for patient selection in minimally invasive deformity surgery.

Journal Article J Neurosurg Spine · February 1, 2020 OBJECTIVE: Minimally invasive surgery (MIS) can be used as an alternative or adjunct to traditional open techniques for the treatment of patients with adult spinal deformity. Recent advances in MIS techniques, including advanced anterior approaches, have i ... Full text Open Access Link to item Cite

Intraoperative neuromonitoring for one-level lumbar discectomies is low yield and cost-ineffective.

Journal Article J Clin Neurosci · January 2020 BACKGROUND: Intraoperative neuromonitoring is a common, well-established modality used in spine surgery to prevent intraoperative neural injury. Neuromonitoring use in lumbar discectomy, however, is based on surgeon preference, without evidence-based data. ... Full text Link to item Cite

Minimally Invasive Advances in Deformity.

Journal Article Neurosurg Clin N Am · January 2020 Adult spinal deformity is a major contributor to pain and disability. It is a degenerative disease with a rigid spine. Spinopelvic parameters have been identified that outline goals of operative intervention, as they have shown to significantly improve pat ... Full text Link to item Cite

Less invasive spinal deformity surgery: the impact of the learning curve at tertiary spine care centers.

Journal Article J Neurosurg Spine · December 1, 2019 OBJECTIVE: The past decade has seen major advances in techniques for treating more complex spinal disorders using minimally invasive surgery (MIS). While appealing from the standpoint of patient perioperative outcomes, a major impediment to adoption has be ... Full text Open Access Link to item Cite

IgG4-related disease presenting as intradural extramedullary lesion: a case report and review of the literature.

Journal Article Br J Neurosurg · October 2019 Object: IgG4-related disease (IgG4-RD) is a fibro-inflammatory disorder affecting various anatomical sites, and only recently was identified to affect the dura of the spine. The authors present the second reported case of an intradural extramedullary lesio ... Full text Link to item Cite

Gastrostomy tube placement increases the risk of ventriculoperitoneal shunt infection: a multiinstitutional study.

Journal Article J Neurosurg · October 1, 2019 OBJECTIVE: Gastrostomy tube placement can temporarily seed the peritoneal cavity with bacteria and thus theoretically increases the risk of shunt infection when the two procedures are performed contemporaneously. The authors hypothesized that gastrostomy t ... Full text Link to item Cite

PEEK interbody device and pseudarthrosis Response

Journal Article JOURNAL OF NEUROSURGERY-SPINE · October 1, 2019 Full text Link to item Cite

Metastatic spine disease in lung cancer patients: national patterns of radiation and surgical care.

Journal Article J Spine Surg · September 2019 BACKGROUND: Lung cancer is the most common source of spinal metastases. As our treatment of spinal metastases evolves, national trends in radiation therapy (RT), including spinal stereotactic neurosurgery, have yet to been established. METHODS: We performe ... Full text Link to item Cite

Spine.

Journal Article Oper Neurosurg (Hagerstown) · August 1, 2019 Full text Link to item Cite

Is achieving optimal spinopelvic parameters necessary to obtain substantial clinical benefit? An analysis of patients who underwent circumferential minimally invasive surgery or hybrid surgery with open posterior instrumentation.

Journal Article J Neurosurg Spine · June 1, 2019 OBJECTIVE: It is now well accepted that spinopelvic parameters are correlated with clinical outcomes in adult spinal deformity (ASD). The purpose of this study was to determine whether obtaining optimal spinopelvic alignment was absolutely necessary to ach ... Full text Link to item Cite

Analysis of Complications with Staged Surgery for Less Invasive Treatment of Adult Spinal Deformity.

Journal Article World Neurosurg · June 2019 BACKGROUND: Spinal deformity surgery is often invasive and lengthy. Staging surgery over separate operative days may reduce complications. Staging is often used in minimally invasive treatment of adult spinal deformity (ASD). OBJECTIVE: To investigate the ... Full text Link to item Cite

ACR Appropriateness Criteria® Suspected Spine Trauma.

Journal Article J Am Coll Radiol · May 2019 Injuries to the cervical and thoracolumbar spine are commonly encountered in trauma patients presenting for treatment. Cervical spine injuries occur in 3% to 4% and thoracolumbar fractures in 4% to 7% of blunt trauma patients presenting to the emergency de ... Full text Link to item Cite

An 11-year analysis of peripheral nerve injuries in high school sports.

Journal Article Phys Sportsmed · May 2019 INTRODUCTION: Sports surveillance databases provide valuable information regarding common ailments, yet fewer studies have focused on more rare peripheral nerve injuries. Our objective was to characterize peripheral nerve injuries in high school athletics ... Full text Link to item Cite

Young Neurosurgeons Committee of the American Association of Neurological Surgeons: Training Ground for Future Leaders in Organized Neurosurgery in the United States of America.

Journal Article World Neurosurg · March 2019 The Young Neurosurgeons Committee, founded in 1991 by Dr. Roberto C. Heros, has been a vital component of the American Association of Neurological Surgeons. It has grown from an opportunity for young neurosurgeons to network with senior neurosurgeons to be ... Full text Link to item Cite

Effect of Resident and Fellow Involvement in Adult Spinal Deformity Surgery.

Journal Article World Neurosurg · February 2019 BACKGROUND: Adult spinal deformity (ASD) operations are complex and often require a multisurgeon team. Simultaneously, it is the responsibility of academic spine surgeons to train future complex spine surgeons. Our objective was to assess the effect of res ... Full text Open Access Link to item Cite

Two-level reverse Bohlman transsoseous approach for treatment of symptomatic pseudarthrosis.

Journal Article Br J Neurosurg · February 2019 Surgical treatment for high-grade spondylolisthesis with high sacral slope remains controversial and no definitive gold standard procedure has been identified. The Bohlman technique, in which a fibular strut is reamed posteriorly across the L5-S1 disc spac ... Full text Link to item Cite

Fivefold higher rate of pseudarthrosis with polyetheretherketone interbody device than with structural allograft used for 1-level anterior cervical discectomy and fusion.

Journal Article J Neurosurg Spine · January 1, 2019 In BriefThe authors examined fusion rates after single-level anterior cervical discectomy and fusion, comparing use of a structural allograft with use of polyetheretherketone (PEEK) interbody devices packed with bone graft. The results demonstrate superior ... Full text Link to item Cite

Global spinal deformity from the upper cervical perspective. What is "Abnormal" in the upper cervical spine?

Journal Article J Craniovertebr Junction Spine · 2019 HYPOTHESIS: Reciprocal changes in the upper cervical spine correlate with adult TL deformity modifiers. DESIGN: This was a retrospective review. INTRODUCTION: The upper cervical spine has remarkable adaptability to wide ranges of thoracolumbar (TL) deformi ... Full text Open Access Link to item Cite

Comment

Journal Article Clinical Neurosurgery · December 1, 2018 Cite

Treatment of the Fractional Curve of Adult Scoliosis With Circumferential Minimally Invasive Surgery Versus Traditional, Open Surgery: An Analysis of Surgical Outcomes.

Journal Article Global Spine J · December 2018 STUDY DESIGN: Retrospective, multicenter review of adult scoliosis patients with minimum 2-year follow-up. OBJECTIVE: Because the fractional curve (FC) of adult scoliosis can cause radiculopathy, we evaluated patients treated with either circumferential mi ... Full text Link to item Cite

The impact of age on surgical goals for spinopelvic alignment in minimally invasive surgery for adult spinal deformity.

Journal Article J Neurosurg Spine · November 1, 2018 OBJECTIVEAchieving appropriate spinopelvic alignment in deformity surgery has been correlated with improvement in pain and disability. Minimally invasive surgery (MIS) techniques have been used to treat adult spinal deformity (ASD); however, there is conce ... Full text Open Access Link to item Cite

Patients with High Pelvic Tilt Achieve the Same Clinical Success as Those with Low Pelvic Tilt After Minimally Invasive Adult Deformity Surgery.

Conference Neurosurgery · August 1, 2018 BACKGROUND: Pelvic tilt (PT) is a compensatory mechanism for adult spinal deformity patients to mitigate sagittal imbalance. The association between preop PT and postop clinical and radiographic outcomes has not been well studied in patients undergoing min ... Full text Link to item Cite

Combined Laminoplasty and Posterior Fusion for Cervical Spondylotic Myelopathy Treatment: A Literature Review.

Journal Article Asian Spine J · June 2018 STUDY DESIGN: A literature review. PURPOSE: To explore the utility of laminoplasty in combination with instrumented fusion, with a focus on neurological outcomes and changes in kyphotic deformity. OVERVIEW OF LITERATURE: Management of cervical spondylotic ... Full text Link to item Cite

Holospinal epidural abscesses - Institutional experience.

Journal Article J Clin Neurosci · February 2018 PURPOSE: The authors present a holospinal epidural abscesses (HEA) case series and a single institution's experience with varied surgical approaches and outcomes. METHODS: Medical records were queried and reviewed (6 years) for patients with a spinal absce ... Full text Link to item Cite

Complication rates associated with open versus percutaneous pedicle screw instrumentation among patients undergoing minimally invasive interbody fusion for adult spinal deformity.

Journal Article Neurosurg Focus · December 2017 OBJECTIVE High-quality studies that compare outcomes of open and minimally invasively placed pedicle screws for adult spinal deformity are needed. Therefore, the authors compared differences in complications from a circumferential minimally invasive spine ... Full text Link to item Cite

Laminoplasty versus laminectomy with posterior spinal fusion for multilevel cervical spondylotic myelopathy: influence of cervical alignment on outcomes.

Conference J Neurosurg Spine · November 2017 OBJECTIVE Cervical curvature is an important factor when deciding between laminoplasty and laminectomy with posterior spinal fusion (LPSF) for cervical spondylotic myelopathy (CSM). This study compares outcomes following laminoplasty and LPSF in patients w ... Full text Link to item Cite

Variability in Assessing Spinopelvic Parameters with Lumbosacral Transitional Vertebrae: Inter- and Intra-observer Reliability among Spine Surgeons.

Journal Article Spine (Phila Pa 1976) · October 3, 2017 STUDY DESIGN: Prospectively-collected survey study OBJECTIVE.: To determine the consistency with which spino-pelvic parameters (SPP) are determined in patients with lumbosacral transitional vertebrae (LSTV). SUMMARY OF BACKGROUND DATA: The incidence of LST ... Full text Link to item Cite

Pseudogout of the cervical and thoracic spine mimicking infection after lumbar fusion: case report.

Journal Article J Neurosurg Spine · August 2017 Pseudogout is a form of acute calcium pyrophosphate deposition (CPPD) disease that typically afflicts the elderly. CPPD commonly involves larger joints, such as the knees, wrists, shoulders, and hips, and has been known to involve the spine. The authors re ... Full text Link to item Cite

Proximal Junctional Kyphosis: Inter- and Intra-observer Reliability of Radiographic Measurements in Adult Spinal Deformity.

Journal Article Spine (Phila Pa 1976) · June 6, 2017 STUDY DESIGN: Reliability study of radiographic measures of proximal junctional kyphosis in adult spinal deformity patients. OBJECTIVE: Assess impacts of level of proximal endpoint and vertebral fracture on reliability of measurement of junctional kyphosis ... Full text Link to item Cite

ACR Appropriateness Criteria® Plexopathy.

Journal Article J Am Coll Radiol · May 2017 MRI without and with contrast is the most accurate imaging method to determine whether a process is intrinsic or extrinsic to a nerve of the brachial or lumbosacral plexus. However, there are no Current Procedural Terminology codes to correspond to imaging ... Full text Link to item Cite

C5 Palsy After Cervical Spine Surgery: A Multicenter Retrospective Review of 59 Cases.

Journal Article Global Spine J · April 2017 STUDY DESIGN: A multicenter, retrospective review of C5 palsy after cervical spine surgery. OBJECTIVE: Postoperative C5 palsy is a known complication of cervical decompressive spinal surgery. The goal of this study was to review the incidence, patient char ... Full text Link to item Cite

A Multicenter Study of the Presentation, Treatment, and Outcomes of Cervical Dural Tears.

Journal Article Global Spine J · April 2017 STUDY DESIGN: Retrospective multicenter case series study. OBJECTIVE: Because cervical dural tears are rare, most surgeons have limited experience with this complication. A multicenter study was performed to better understand the presentation, treatment, a ... Full text Open Access Link to item Cite

Rare Complications of Cervical Spine Surgery: Pseudomeningocoele.

Journal Article Global Spine J · April 2017 STUDY DESIGN: This study was a retrospective, multicenter cohort study. OBJECTIVES: Rare complications of cervical spine surgery are inherently difficult to investigate. Pseudomeningocoele (PMC), an abnormal collection of cerebrospinal fluid that communica ... Full text Open Access Link to item Cite

Brachial Plexopathy After Cervical Spine Surgery.

Journal Article Global Spine J · April 2017 STUDY DESIGN: Retrospective, multicenter case-series study and literature review. OBJECTIVES: To determine the prevalence of brachial plexopathy after cervical spine surgery and to review the literature to better understand the etiology and risk factors of ... Full text Link to item Cite

Stereotactic radiosurgery versus surgical resection for spinal hemangioblastoma: A systematic review.

Journal Article Clin Neurol Neurosurg · March 2017 Spinal cord hemangioblastomas are benign vascular tumors arising sporadically in approximately 70-80% of cases. They can also be manifestations of von Hippel-Lindau (VHL) disease, as these patients will often have multiple spinal hemangioblastomas. Histori ... Full text Link to item Cite

Cervical osteomyelitis and kyphosis complication

Chapter · January 1, 2017 Management of cervical spinal infections is a frequent problem encountered by spine surgeons. While categorized as a single disease process, cervical infections are, in reality, a combination of two separate issues: treatment of infected tissues (consistin ... Full text Cite

How to predict return to work after lumbar discectomy: answers from the NeuroPoint-SD registry.

Conference J Neurosurg Spine · August 2016 OBJECTIVE To date, the factors that predict whether a patient returns to work after lumbar discectomy are poorly understood. Information on postoperative work status is important in analyzing the cost-effectiveness of the procedure. METHODS An observationa ... Full text Link to item Cite

165 What Is the Effect of Open vs Percutaneous Screws on Complications Among Patients Undergoing Lateral Interbody Fusion for Adult Spinal Deformity?

Journal Article Neurosurgery · August 1, 2016 RESULTS: Of 420 patients that met inclusion criteria, 165 had complete data. One hundred thirty-seven were available for analysis after excluding 3 column osteotomies and 76 remained after propensity matching (38 cMIS and 38 HYB). There were no differences ... Full text Cite

169 Laminoplasty vs Laminectomy With Posterior Spinal Fusion for Multilevel Cervical Spondylotic Myelopathy: Matched Cohorts of Regional Sagittal Balance

Journal Article Neurosurgery · August 1, 2016 INTRODUCTION: Cervical curvature is an important factor when deciding between laminoplasty or laminectomy with posterior spinal fusion (PSF). This study compares outcomes of laminoplasty and laminectomy with PSF in patients with matched regional sagittal b ... Full text Cite

Clinical and radiographic parameters associated with best versus worst clinical outcomes in minimally invasive spinal deformity surgery.

Journal Article J Neurosurg Spine · July 2016 OBJECTIVE Minimally invasive surgery (MIS) techniques are increasingly used to treat adult spinal deformity. However, standard minimally invasive spinal deformity techniques have a more limited ability to restore sagittal balance and match the pelvic incid ... Full text Open Access Link to item Cite

Resolution of innumerable cerebral Nocardia paucivorans abscesses after medical management.

Journal Article J Clin Neurosci · May 2016 Nocardia species are an infrequent cause of brain abscesses. We report a 50-year-old man with Nocardia paucivorans cerebral abscesses. Brain MRI revealed innumerable small ring-enhancing lesions. The patient initially responded to treatment with antibiotic ... Full text Link to item Cite

Comments

Journal Article Neurosurgery · April 1, 2016 Full text Cite

Can a Minimal Clinically Important Difference Be Achieved in Elderly Patients with Adult Spinal Deformity Who Undergo Minimally Invasive Spinal Surgery?

Journal Article World Neurosurg · February 2016 BACKGROUND: Older age has been considered a relative contraindication to complex spinal procedures. Minimally invasive surgery (MIS) techniques to treat patients with adult spinal deformity (ASD) have emerged with the potential benefit of decreased approac ... Full text Open Access Link to item Cite

Appropriate Use of Limited Interventions vs Extensive Surgery in the Elderly Patient With Spinal Disorders.

Journal Article Neurosurgery · October 2015 Surgical management of spinal deformity is elderly patients is characterized by significant variability. In a value-based health care economy, minimization of risks and maximization of benefit and durability of surgery are a priority. The choice of a surgi ... Full text Link to item Cite

Comparison of minimally invasive transspinous and open approaches for thoracolumbar intradural-extramedullary spinal tumors.

Journal Article Neurosurg Focus · August 2015 OBJECT Spinal tumor resection has historically been performed via open approaches, although minimally invasive approaches have recently been found to be effective in small cohort series. The authors compare surgical characteristics and clinical outcomes of ... Full text Link to item Cite

BMP-2 inhibits tumor-initiating ability in human renal cancer stem cells and induces bone formation.

Journal Article J Cancer Res Clin Oncol · June 2015 PURPOSE: We have previously shown that BMP-2 induces bone formation and inhibits tumorigenicity of cancer stem cells (CSCs) in a human osteosarcoma OS99-1 cell line. In this study, we sought to determine whether BMP-2 can similarly induce bone formation an ... Full text Link to item Cite

Failure of a polyether-ether-ketone expandable interbody cage following transforaminal lumbar interbody fusion.

Journal Article Eur Spine J · May 2015 PURPOSE: Expandable cages are a more recent option for maintaining or restoring disc height and segmental lordosis with transforaminal lumbar interbody fusion (TLIF). Complications associated with expandable cages have not yet been widely reported. We repo ... Full text Link to item Cite

Radiation safety and spine surgery: systematic review of exposure limits and methods to minimize radiation exposure.

Journal Article World Neurosurg · December 2014 BACKGROUND: Ionizing radiation is typically used during spine surgery for localization and guidance in instrumentation placement. Minimally invasive (MI) surgical procedures are increasingly popular and often require significantly more fluoroscopy, placing ... Full text Link to item Cite

Cost effectiveness of a short-term pediatric neurosurgical brigade to Guatemala.

Journal Article World Neurosurg · December 2014 OBJECTIVE: With subspecialty surgical care often unavailable to poor patients in developing countries, short-term brigades have filled a portion of the gap. We prospectively assessed the cost effectiveness of a pediatric neurosurgical brigade to Guatemala ... Full text Link to item Cite

Hemorrhagic vestibular schwannoma: review of the literature.

Journal Article World Neurosurg · November 2014 BACKGROUND: Clinically significant intratumoral hemorrhage historically has been reported in only a small fraction of vestibular schwannomas (VS). Patients with hemorrhagic VS are more likely to present with neurologic deficits and have worse outcomes than ... Full text Link to item Cite

Perioperative characteristics and complications in obese patients undergoing anterior cervical fusion surgery.

Journal Article J Clin Neurosci · July 2014 In the USA, obesity rates have significantly increased in the last 15 years. Mirroring this trend, a large proportion of patients undergoing spinal surgery are obese. Concern exists for increased complications due to surgical challenges posed by obese pati ... Full text Link to item Cite

Intradiscal injection of simvastatin results in radiologic, histologic, and genetic evidence of disc regeneration in a rat model of degenerative disc disease.

Journal Article Spine J · June 1, 2014 BACKGROUND CONTEXT: A large percentage of back pain can be attributed to degeneration of the intervertebral disc (IVD). Bone morphogenetic protein 2 (BMP-2) is known to play an important role in chondrogenesis of the IVD. Simvastatin is known to upregulate ... Full text Link to item Cite

Sleep apnea and cervical spine pathology.

Journal Article Eur Spine J · March 2014 PURPOSE: Sleep apnea is a multi-factorial disease with a variety of identified causes. With its close proximity to the upper airway, the cervical spine and its associated pathologies can produce sleep apnea symptoms in select populations. The aim of this a ... Full text Link to item Cite

Independent predictors for local recurrence following surgery for spinal metastasis.

Journal Article Acta Neurochir (Wien) · February 2014 BACKGROUND: Local recurrence of spinal metastasis after surgical resection is relatively common. We sought to determine risk factors and independent predictors for local recurrence after primary surgical resection of spinal metastasis. METHODS: Demographic ... Full text Link to item Cite

Role of Neuromonitoring in Minimally Invasive Lateral Approaches to the Spine

Chapter · January 1, 2014 Minimally invasive approaches allow surgeons to achieve clinical outcomes similar to traditional open approaches but with decreased blood loss, postoperative pain, and length of hospital stay. In 1998, a minimally invasive retroperitoneal transpsoas approa ... Full text Cite

Thermoelectrical modeling of bipolar coagulation on posterior spinal artery in a porcine spinal surgery model.

Journal Article IEEE Trans Biomed Eng · January 2014 The primary objective of our study was to develop a thermoelectrical model with both solid and liquid phases to calculate tissue temperature during bipolar coagulation of a posterior spinal artery on the spinal cord. Control of thermal spread caused by coa ... Full text Link to item Cite

Bone formation induced by BMP-2 in human osteosarcoma cells.

Journal Article Int J Oncol · October 2013 Our previous studies demonstrated that BMP-2 inhibits the tumorigenicity of cancer stem cells identified as cells with high aldehyde dehydrogenase activity (ALDH(br) cells) from the human osteosarcoma cell line OS99-1. We further investigated whether BMP-2 ... Full text Link to item Cite

Symptomatic calcified perineural cyst after use of bone morphogenetic protein in transforaminal lumbar interbody fusion: a case report.

Journal Article Spine J · August 2013 BACKGROUND CONTEXT: Human recombinant bone morphogenetic protein-2 (BMP-2) is commonly used in spinal surgery to augment arthrodesis, and a number of potential complications have been documented. PURPOSE: To present the case of a delayed radiculopathy that ... Full text Link to item Cite

Minimally invasive unilateral approach for bilateral decompression of spinal stenosis and modified transforaminal lumbar interbody fusion for degenerative spondylolisthesis.

Journal Article Neurosurg Focus · July 2013 This video describes a minimally invasive approach for treatment of symptomatic grade I spondylolisthesis and high-grade spinal stenosis. In this procedure, a unilateral approach for bilateral decompression is utilized in conjunction with a modified transf ... Full text Link to item Cite

Minimally invasive deformity correction: surgical technique.

Journal Article Neurosurg Focus · July 2013 This video details a minimally invasive treatment of symptomatic adult kyphoscoliosis. Both anterior and posterior approaches are used to obtain sagittal and coronal balance. In addition, improved lumbar lordosis is achieved to closely match the patient's ... Full text Link to item Cite

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Journal Article Neurosurgery · July 1, 2013 Full text Cite

Durability of hearing preservation after microsurgical treatment of vestibular schwannoma using the middle cranial fossa approach.

Journal Article J Neurosurg · July 2013 OBJECT: The middle cranial fossa (MCF) approach is a microsurgical technique described as a primary option in the treatment of small, intracanalicular schwannomas involving the eighth cranial nerve. Excellent rates of complete tumor resection, hearing pres ... Full text Link to item Cite

Independent predictors of complication following surgery for spinal metastasis.

Journal Article Eur Spine J · June 2013 PURPOSE: Surgery for spinal metastasis is often associated with significant morbidity. Despite a number of preoperative scoring systems/scales and identified variables that have been reported to predict complication risk, clinical studies that directly eva ... Full text Link to item Cite

Controlled release of simvastatin from in situ forming hydrogel triggers bone formation in MC3T3-E1 cells.

Journal Article AAPS J · April 2013 Simvastatin (SIM), a drug commonly administered for the treatment of hypercholesterolemia, has been recently reported to induce bone regeneration/formation. In this study, we investigated the properties of hydrogel composed of gelatin-poly(ethylene glycol) ... Full text Link to item Cite

The current status and recent advances in high-resolution imaging of spinal vascular malformations.

Journal Article J Clin Neurosci · January 2013 The management of spinal vascular malformations (SVM) has improved over the last four decades with the evolution of imaging, anesthesia, microsurgery, and endovascular techniques. Commonly used high-resolution imaging techniques include CT angiography, mag ... Full text Link to item Cite

Comparison of thermal coagulation profiles for bipolar forceps with different cooling mechanisms in a porcine model of spinal surgery.

Journal Article Surg Neurol Int · 2013 BACKGROUND: Coagulation accomplished using bipolar forceps is common in neurosurgery. Control of thermal spread from the forceps tips into surrounding neural tissues is a persistent concern, as neural tissues are especially vulnerable to heat injury. The p ... Full text Link to item Cite

Anterior clinoid mucocele presenting with orbital apex syndrome.

Journal Article Surg Neurol Int · 2013 BACKGROUND: Pneumatized anterior clinoid process is a common anatomic variant. Mucocele formation is a known complication of clinoid drilling during certain intracranial operations; however, mucoceles of pneumatized anterior clinoid processes have been fou ... Full text Link to item Cite

Schmorl's nodes.

Journal Article Eur Spine J · November 2012 INTRODUCTION: First described in 1927, a Schmorl's node (SN) is the herniation of nucleus pulposus (NP) through the cartilaginous and bony end plate into the body of the adjacent vertebra. SNs are common findings on imaging, and although most SNs are asymp ... Full text Link to item Cite

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Journal Article Neurosurgery · November 1, 2012 Full text Cite

BMP-2 inhibits tumor growth of human renal cell carcinoma and induces bone formation.

Journal Article Int J Cancer · October 15, 2012 Bone morphogenetic protein-2 (BMP-2), a member of the transforming growth factor superfamily, has been shown to have inhibitory effect on many tumor types. However, the effect of BMP-2 on human renal cell carcinoma (RCC) is still unknown. We previously sho ... Full text Link to item Cite

Perioperative management of a neurosurgical patient requiring antiplatelet therapy.

Journal Article J Clin Neurosci · September 2012 In patients who undergo neurovascular stent placement with postoperative dual antiplatelet therapy to prevent in-stent thrombosis, there is no protocol for balancing the risk of acute stent thrombosis and bleeding if urgent neurosurgical procedures are req ... Full text Link to item Cite

Pineal region myeloid sarcoma.

Journal Article J Clin Neurosci · July 2012 The overwhelming majority of pineal region tumors are malignant germ cell tumors, pineal cell tumors, or glial tumors. To our knowledge we report the first patient with myeloid sarcoma in the pineal region. Myeloid sarcomas are composed of immature granulo ... Full text Link to item Cite

Evaluating the use and utility of noninvasive angiography in diagnosing traumatic blunt cerebrovascular injury.

Journal Article J Trauma Acute Care Surg · June 2012 BACKGROUND: Digital subtraction angiography (DSA) is the gold standard for radiographic diagnosis of blunt cerebrovascular injury (BCVI), but use of computed tomography angiography (CTA) and magnetic resonance angiography (MRA) has increased dramatically i ... Full text Link to item Cite

A novel murine model of human renal cell carcinoma spinal metastasis.

Journal Article J Clin Neurosci · June 2012 There is currently no reproducible animal model of renal cell carcinoma (RCC) spinal metastasis that allows for laboratory study of the human disease. In this report, we describe an animal model that reliably reproduces RCC spinal metastasis using a human ... Full text Link to item Cite

Bone morphogenetic proteins and degenerative disk disease.

Journal Article Neurosurgery · April 2012 Bone morphogenetic proteins (BMPs) are involved not only in osteogenesis but also in chondrogenesis. They play an important role in the development and maintenance of the intervertebral disk (IVD). For this reason, an increasing amount of research has been ... Full text Link to item Cite

Tarlov cysts Response

Journal Article NEUROSURGICAL FOCUS · April 1, 2012 Link to item Cite

Tarlov cysts: a controversial lesion of the sacral spine.

Journal Article Neurosurg Focus · December 2011 The primary aim of our study was to provide a comprehensive review of the clinical, imaging, and histopathological features of Tarlov cysts (TCs) and to report operative and nonoperative management strategies in patients with sacral TCs. A literature revie ... Full text Link to item Cite

Patient with Chiari malformation Type I presenting with inducible hemifacial weakness.

Journal Article J Neurosurg Pediatr · December 2011 In this report, the authors describe the first known case of inducible hemifacial weakness in a patient with Chiari malformation Type I (CM-I). The patient was a 14-year-old girl with a 1-year history of right facial paresis induced by sustained leftward h ... Full text Link to item Cite

Spontaneous intracranial hemorrhage and multiple intracranial aneurysms in a patient with Roberts/SC phocomelia syndrome.

Journal Article J Neurosurg Pediatr · November 2011 Roberts/SC phocomelia syndrome (RBS) is a rare but distinct genetic disorder with an autosomal recessive inheritance pattern. It has been associated with microcephaly, craniofacial malformation, cavernous hemangioma, encephalocele, and hydrocephalus. There ... Full text Link to item Cite

Non-ketotic hyperglycemic chorea-hemiballismus mimicking basal ganglia hemorrhage.

Journal Article J Clin Neurosci · November 2011 Radiographic findings of hyperglycemic non-ketotic chorea-hemiballismus and basal ganglia hemorrhage can be highly similar. A 58-year-old female presented with a 1-week history of choreiform and ballistic movements of the left arm. Based on CT imaging, the ... Full text Link to item Cite

Complication avoidance and management in anterior lumbar interbody fusion.

Journal Article Neurosurg Focus · October 2011 The goal of this study was to review the literature to compare strategies for avoiding and treating complications from anterior lumbar interbody fusion (ALIF), and thus provide a comprehensive aid for spine surgeons. A thorough review of databases from the ... Full text Link to item Cite

Metastatic malignant peripheral nerve sheath tumor of the cauda equina.

Journal Article J Clin Neurosci · June 2011 Malignant peripheral nerve sheath tumor (MPNST) of the cauda equina is rare, with only four reported patients in the literature. We present a 70-year-old woman with a history of left sciatic nerve MPNST that had been treated by left hemipelvectomy 4 years ... Full text Link to item Cite

Subarachnoid hemorrhage during aneurysm coiling

Chapter · January 1, 2011 Intraprocedural rupture of an intracranial aneurysm is a potentially catastrophic complication, but can be even more devastating in a heparinized patient in an offsite interventional suite. Understanding how to respond to such an event is essential to good ... Full text Cite

Impact of multimodal intraoperative monitoring during correction of symptomatic cervical or cervicothoracic kyphosis.

Journal Article J Neurosurg Spine · January 2011 OBJECT: surgical correction of symptomatic cervical or cervicothoracic kyphosis involves the potential for significant neurological complications. Intraoperative monitoring has been shown to reduce the risk of neurological injury in scoliosis surgery, but ... Full text Link to item Cite

Cancer stem cell markers: what is their diagnostic value?

Journal Article Expert Opin Med Diagn · November 2010 IMPORTANCE OF THE FIELD: Cancer resistance to conventional therapies has been attributed to cancer stem cells (CSCs). Although a variety of markers have been reported, a universal marker has not yet been found to identify CSCs. Better identification of the ... Full text Link to item Cite

Solitary spinal metastasis of Hürthle cell thyroid carcinoma.

Journal Article J Clin Neurosci · June 2010 Hürthle cell carcinoma is a rare variant of differentiated thyroid cancer that occasionally forms distant metastases. However, even in the presence of metastases, patients with Hürthle cell carcinoma have a relatively good prognosis. There are few reports ... Full text Link to item Cite

Modified trans-oral approach with an inferiorly based flap.

Journal Article J Clin Neurosci · April 2010 The trans-oral approach allows direct access to pathologies of the anterior craniocervical junction. However, the classic midline incision of the posterior pharyngeal wall can be surgically burdensome and limits lateral exposure. We reviewed the medical re ... Full text Link to item Cite

Outcomes after surgery for cervical spine deformity: review of the literature.

Journal Article Neurosurg Focus · March 2010 OBJECT: Symptomatic cervical kyphosis can result from a variety of causes. Symptoms can include pain, neurological deficits, and functional limitation due to loss of horizontal gaze. METHODS: The authors review the long-term functional and radiographic out ... Full text Link to item Cite

Bone morphogenetic proteins and cancer: review of the literature.

Journal Article Neurosurgery · February 2010 OBJECTIVE: In addition to their well-known osteogenic properties, bone morphogenetic proteins (BMPs) have developmental and regenerative roles that may impact tumorigenesis and promote tumor spread. Given that the most common site of tumor metastases to bo ... Full text Link to item Cite

Clinical and radiographic outcomes after minimally invasive transforaminal lumbar interbody fusion.

Journal Article SAS J · 2010 OBJECTIVE: To evaluate outcomes after minimally invasive transforaminal lumbar interbody fusion (MI-TLIF). BACKGROUND: MI-TLIF is a relatively novel technique for treating symptomatic spondylolisthesis and degenerative disc disease of the lumbar spine. It ... Full text Link to item Cite

Impact of anesthesia on transcranial electric motor evoked potential monitoring during spine surgery: a review of the literature.

Journal Article Neurosurg Focus · October 2009 OBJECT: Transcranial motor evoked potential (TcMEP) monitoring is frequently used in complex spinal surgeries to prevent neurological injury. Anesthesia, however, can significantly affect the reliability of TcMEP monitoring. Understanding the impact of var ... Full text Link to item Cite

Association of surgically acquired motor and language deficits on overall survival after resection of glioblastoma multiforme.

Journal Article Neurosurgery · September 2009 OBJECTIVE: Balancing the benefits of extensive tumor resection with the consequence of potential postoperative deficits remains a challenge in malignant astrocytoma surgery. Although studies have suggested that increasing extent of resection may benefit su ... Full text Link to item Cite

Association of preoperative depression and survival after resection of malignant brain astrocytoma.

Journal Article Surg Neurol · March 2009 BACKGROUND: Clinical depression has been shown to negatively influence the morbidity and mortality of multiple disease states. It remains unclear if clinical depression affects survival after surgical management of malignant brain astrocytoma. We set out t ... Full text Link to item Cite

Gliadel (BCNU) wafer plus concomitant temozolomide therapy after primary resection of glioblastoma multiforme.

Journal Article J Neurosurg · March 2009 OBJECT: Gliadel (BCNU) wafer and concomitant temozolomide (TMZ) therapy, when used individually as adjuvant therapies, extend survival from that achieved by resection and radiation therapy (XRT) for glioblastoma multiforme (GBM). It remains unstudied wheth ... Full text Link to item Cite

Independent association of extent of resection with survival in patients with malignant brain astrocytoma.

Journal Article J Neurosurg · January 2009 OBJECT: With recent advances in the adjuvant treatment of malignant brain astrocytomas, it is increasingly debated whether extent of resection affects survival. In this study, the authors investigate this issue after primary and revision resection of these ... Full text Link to item Cite

Extent of surgical resection is independently associated with survival in patients with hemispheric infiltrating low-grade gliomas.

Journal Article Neurosurgery · October 2008 OBJECTIVE: It remains unknown whether the extent of surgical resection affects survival or disease progression in patients with supratentorial low-grade gliomas. METHODS: We conducted a retrospective cohort study (n = 170) between 1996 and 2007 at a single ... Full text Link to item Cite

Postoperative management of incidental durotomy in minimally invasive lumbar spinal surgery.

Journal Article Minim Invasive Neurosurg · October 2008 Unintended durotomy is a relatively common complication in spine surgery, with a reported incidence up to 14%. Traditional management has been mandatory bed rest for at least 48 h following repair, with or without placement of a drain. With the muscle-spli ... Full text Link to item Cite

Persistent outpatient hyperglycemia is independently associated with decreased survival after primary resection of malignant brain astrocytomas.

Journal Article Neurosurgery · August 2008 OBJECTIVE: Patients with malignant brain astrocytomas are at high risk for developing hyperglycemia secondary to frequent corticosteroid administration. Several clinical studies have shown that hyperglycemia is associated with poor outcome in multiple dise ... Full text Link to item Cite

Surgical management of symptomatic cervical or cervicothoracic kyphosis due to ankylosing spondylitis.

Journal Article Spine (Phila Pa 1976) · July 15, 2008 STUDY DESIGN: Literature review. OBJECTIVE: To evaluate surgical management and outcomes in the treatment of severe chin-on-chest deformities due to ankylosing spondylitis (AS). SUMMARY OF BACKGROUND DATA: AS is a chronic inflammatory disease that can lead ... Full text Link to item Cite

Polyethylene glycol hydrogel dural sealant may reduce incisional cerebrospinal fluid leak after posterior fossa surgery.

Journal Article Neurosurgery · July 2008 OBJECTIVE: Incisional cerebrospinal fluid (CSF) leak remains a significant cause of morbidity, particularly after posterior fossa surgery, with ranges between 4 and 17% in most series. We aimed to determine whether the use of a new polyethylene glycol (PEG ... Full text Link to item Cite

Persistent perioperative hyperglycemia as an independent predictor of poor outcome after aneurysmal subarachnoid hemorrhage.

Journal Article J Neurosurg · December 2007 OBJECT: The authors of previous studies have shown that admission hyperglycemia or perioperative hyperglycemic events may predispose a patient to poor outcome after aneurysmal subarachnoid hemorrhage (SAH). The results of experimental evidence have suggest ... Full text Link to item Cite

Selective versus routine intraoperative shunting during carotid endarterectomy: a multivariate outcome analysis.

Journal Article Neurosurgery · December 2007 OBJECTIVE: The use of intraluminal shunting during carotid endarterectomy (CEA) remains controversial. Over the years, different shunting strategies have been used. More recently, the use of intraoperative electroencephalography and somatosensory evoked po ... Full text Link to item Cite

CT fluoroscopically guided percutaneous placement of transiliosacral rod for sacral insufficiency fracture: case report and technique.

Journal Article AJNR Am J Neuroradiol · September 2007 Treatment of sacral insufficiency fractures (SIFs) has traditionally been conservative, but several patients have been treated with percutaneous sacroplasty. Unfortunately, in the setting of severe, bilateral SIFs, cement may not withstand shear forces pre ... Full text Link to item Cite

Symptomatic mass effect of a hypertrophied pericranial flap after repair of a dural defect: case report.

Journal Article Neurosurgery · April 2007 OBJECTIVE: To detail a potential complication of the use of vascularized pericranial flaps in the repair of dural defects, namely, flap hypertrophy secondary to venous engorgement. CLINICAL PRESENTATION: A 23-year-old man with a left parietal lobe hemangio ... Full text Link to item Cite

Acid- and base-catalyzed hydrolysis of chloroacetamide herbicides.

Journal Article J Agric Food Chem · June 28, 2006 Despite the prevalence of chloroacetamides as herbicides, little is known about the rates or products of acid- or base-catalyzed hydrolysis of these compounds. Mechanisms of acid-catalyzed reactions may parallel those catalyzed by (hydr)oxide minerals, whi ... Full text Link to item Cite

Can you predict an immediate, complete, and sustained response to the ketogenic diet?

Journal Article Epilepsia · April 2005 PURPOSE: Although the ketogenic diet has been in use for >80 years, little agreement exists as to which patients are most likely to have dramatic, sudden, and complete seizure control. METHODS: A case-control study was performed of children with intractabl ... Full text Link to item Cite

Response.

Journal Article Buddhist-Christian Studies · January 1, 1993 Link to item Cite