Journal ArticleN Am Spine Soc J · December 2024
BACKGROUND: Traumatic thoracolumbar fracture fixation without neurological injury can be performed using the traditional open, mini-open Wiltse, and percutaneous approaches. This systematic review and meta-analysis aims to compare perioperative outcomes be ...
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Journal ArticleJ Bone Joint Surg Am · September 18, 2024
BACKGROUND: Our understanding of the relationship between sagittal alignment and mechanical complications is evolving. In normal spines, the L1-pelvic angle (L1PA) accounts for the magnitude and distribution of lordosis and is strongly associated with pelv ...
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ConferenceJ Neurosurg Spine · July 1, 2024
OBJECTIVE: The objective of this study was to compare clinical and patient-reported outcomes (PROs) between posterior foraminotomy and anterior cervical discectomy and fusion (ACDF) in patients presenting with cervical radiculopathy. METHODS: The Quality O ...
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Journal ArticleWorld Neurosurg · June 2024
BACKGROUND: Opioids are often prescribed for patients who eventually undergo lumbar decompression. Given the potential for opioid-related morbidity and mortality, postoperative weaning is often a goal of surgery. The purpose of this study was to examine th ...
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Journal ArticleWorld Neurosurg · May 2024
INTRODUCTION: The Coronavirus disease 2019 pandemic ushered a paradigm shift in medical education, accelerating the transition to virtual learning in select cases. The Virtual Global Spine Conference (VGSC), launched at the height of the pandemic, is a tes ...
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Journal ArticleJ Clin Med · April 15, 2024
Background/Objectives: Lateral spine surgery offers effective minimally invasive deformity correction, but traditional approaches often involve separate anterior, lateral, and posterior procedures. The prone lateral technique streamlines this process by al ...
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Journal ArticleJ Neurosurg Spine · April 1, 2024
OBJECTIVE: The aim of this study was to identify predictors of the best 24-month improvements in patients undergoing surgery for cervical spondylotic myelopathy (CSM). For this purpose, the authors leveraged a large prospective cohort of surgically treated ...
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Journal ArticleJ Neurosurg Spine · April 1, 2024
OBJECTIVE: The objective was to determine the degree of regional decompensation to pelvic tilt (PT) normalization after complex adult spinal deformity (ASD) surgery. METHODS: Operative ASD patients with 1 year of PT measurements were included. Patients wit ...
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Journal ArticleJ Neurosurg Spine · April 1, 2024
OBJECTIVE: It is not clear whether there is an additive effect of social factors in keeping patients with cervical spondylotic myelopathy (CSM) from achieving both a minimum clinically important difference (MCID) in outcomes and satisfaction after surgery. ...
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Journal ArticleJ Neurosurg Spine · March 1, 2024
OBJECTIVE: Diabetes mellitus (DM) is a known risk factor for postsurgical and systemic complications after lumbar spinal surgery. Smaller studies have also demonstrated diminished improvements in patient-reported outcomes (PROs), with increased reoperation ...
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Journal ArticleJ Clin Med · February 16, 2024
The Prone Transpsoas (PTP) approach to lumbar spine surgery, emerging as an evolution of lateral lumbar interbody fusion (LLIF), offers significant advantages over traditional methods. PTP has demonstrated increased lumbar lordosis gains compared to LLIF, ...
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Journal ArticleJ Neurosurg Spine · February 1, 2024
OBJECTIVE: The aim of this study was to explore the preoperative patient characteristics that affect surgical decision-making when selecting an anterior or posterior operative approach in patients diagnosed with cervical spondylotic myelopathy (CSM). METHO ...
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Journal ArticleInt J Spine Surg · December 27, 2023
Spinal fusion is important for the clinical success of patients undergoing surgery, and the immune system plays an increasingly recognized role. Osteoimmunology is the study of the interactions between the immune system and bone. Inflammation impacts the o ...
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Journal ArticleWorld Neurosurg · December 2023
INTRODUCTION: Anterior cervical discectomy and fusion (ACDF) is among the most common spine procedures. Adjacent segment disease (ASD), characterized by degenerative disease at an adjacent spinal level to a prior fusion, is a well-recognized and significan ...
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Journal ArticleNeurospine · December 2023
OBJECTIVE: Achieving successful fusion during spine surgery is dependent on rigid pedicle screw fixation. To assess fixation strength, the insertional torque can be measured during intraoperative screw fixation. This study aimed to explore the technical fe ...
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Journal ArticleNeurosurg Clin N Am · October 2023
Outcome assessment in adult spinal deformity has evolved from radiographic analysis of curve correction to patient-centered perception of health-related quality-of-life. Oswestry Disability Index and the Scoliosis Research Society-22 Patient Questionnaire ...
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Journal ArticleJ Spine Surg · September 22, 2023
Surgical correction of fixed kyphotic deformity or severe sagittal imbalance traditionally involves three column osteotomies, which are associated with high morbidity rates. Anterior column realignment (ACR) has emerged as a minimally invasive alternative ...
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Journal ArticleJ Neurotrauma · September 2023
There is a paucity of data comparing the demographics, mechanism of injury, and outcomes of upper versus lower cervical spinal cord injuries (cSCI). The study objective was to define different clinical manifestations of cSCI. Data were collected prospectiv ...
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Journal ArticleN Am Spine Soc J · December 2024
BACKGROUND: Traumatic thoracolumbar fracture fixation without neurological injury can be performed using the traditional open, mini-open Wiltse, and percutaneous approaches. This systematic review and meta-analysis aims to compare perioperative outcomes be ...
Full textLink to itemCite
Journal ArticleJ Bone Joint Surg Am · September 18, 2024
BACKGROUND: Our understanding of the relationship between sagittal alignment and mechanical complications is evolving. In normal spines, the L1-pelvic angle (L1PA) accounts for the magnitude and distribution of lordosis and is strongly associated with pelv ...
Full textLink to itemCite
ConferenceJ Neurosurg Spine · July 1, 2024
OBJECTIVE: The objective of this study was to compare clinical and patient-reported outcomes (PROs) between posterior foraminotomy and anterior cervical discectomy and fusion (ACDF) in patients presenting with cervical radiculopathy. METHODS: The Quality O ...
Full textLink to itemCite
Journal ArticleWorld Neurosurg · June 2024
BACKGROUND: Opioids are often prescribed for patients who eventually undergo lumbar decompression. Given the potential for opioid-related morbidity and mortality, postoperative weaning is often a goal of surgery. The purpose of this study was to examine th ...
Full textLink to itemCite
Journal ArticleWorld Neurosurg · May 2024
INTRODUCTION: The Coronavirus disease 2019 pandemic ushered a paradigm shift in medical education, accelerating the transition to virtual learning in select cases. The Virtual Global Spine Conference (VGSC), launched at the height of the pandemic, is a tes ...
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Journal ArticleJ Clin Med · April 15, 2024
Background/Objectives: Lateral spine surgery offers effective minimally invasive deformity correction, but traditional approaches often involve separate anterior, lateral, and posterior procedures. The prone lateral technique streamlines this process by al ...
Full textOpen AccessLink to itemCite
Journal ArticleJ Neurosurg Spine · April 1, 2024
OBJECTIVE: The aim of this study was to identify predictors of the best 24-month improvements in patients undergoing surgery for cervical spondylotic myelopathy (CSM). For this purpose, the authors leveraged a large prospective cohort of surgically treated ...
Full textOpen AccessLink to itemCite
Journal ArticleJ Neurosurg Spine · April 1, 2024
OBJECTIVE: The objective was to determine the degree of regional decompensation to pelvic tilt (PT) normalization after complex adult spinal deformity (ASD) surgery. METHODS: Operative ASD patients with 1 year of PT measurements were included. Patients wit ...
Full textOpen AccessLink to itemCite
Journal ArticleJ Neurosurg Spine · April 1, 2024
OBJECTIVE: It is not clear whether there is an additive effect of social factors in keeping patients with cervical spondylotic myelopathy (CSM) from achieving both a minimum clinically important difference (MCID) in outcomes and satisfaction after surgery. ...
Full textOpen AccessLink to itemCite
Journal ArticleJ Neurosurg Spine · March 1, 2024
OBJECTIVE: Diabetes mellitus (DM) is a known risk factor for postsurgical and systemic complications after lumbar spinal surgery. Smaller studies have also demonstrated diminished improvements in patient-reported outcomes (PROs), with increased reoperation ...
Full textOpen AccessLink to itemCite
Journal ArticleJ Clin Med · February 16, 2024
The Prone Transpsoas (PTP) approach to lumbar spine surgery, emerging as an evolution of lateral lumbar interbody fusion (LLIF), offers significant advantages over traditional methods. PTP has demonstrated increased lumbar lordosis gains compared to LLIF, ...
Full textOpen AccessLink to itemCite
Journal ArticleJ Neurosurg Spine · February 1, 2024
OBJECTIVE: The aim of this study was to explore the preoperative patient characteristics that affect surgical decision-making when selecting an anterior or posterior operative approach in patients diagnosed with cervical spondylotic myelopathy (CSM). METHO ...
Full textOpen AccessLink to itemCite
Journal ArticleInt J Spine Surg · December 27, 2023
Spinal fusion is important for the clinical success of patients undergoing surgery, and the immune system plays an increasingly recognized role. Osteoimmunology is the study of the interactions between the immune system and bone. Inflammation impacts the o ...
Full textOpen AccessLink to itemCite
Journal ArticleWorld Neurosurg · December 2023
INTRODUCTION: Anterior cervical discectomy and fusion (ACDF) is among the most common spine procedures. Adjacent segment disease (ASD), characterized by degenerative disease at an adjacent spinal level to a prior fusion, is a well-recognized and significan ...
Full textOpen AccessLink to itemCite
Journal ArticleNeurospine · December 2023
OBJECTIVE: Achieving successful fusion during spine surgery is dependent on rigid pedicle screw fixation. To assess fixation strength, the insertional torque can be measured during intraoperative screw fixation. This study aimed to explore the technical fe ...
Full textLink to itemCite
Journal ArticleNeurosurg Clin N Am · October 2023
Outcome assessment in adult spinal deformity has evolved from radiographic analysis of curve correction to patient-centered perception of health-related quality-of-life. Oswestry Disability Index and the Scoliosis Research Society-22 Patient Questionnaire ...
Full textOpen AccessLink to itemCite
Journal ArticleJ Spine Surg · September 22, 2023
Surgical correction of fixed kyphotic deformity or severe sagittal imbalance traditionally involves three column osteotomies, which are associated with high morbidity rates. Anterior column realignment (ACR) has emerged as a minimally invasive alternative ...
Full textOpen AccessLink to itemCite
Journal ArticleJ Neurotrauma · September 2023
There is a paucity of data comparing the demographics, mechanism of injury, and outcomes of upper versus lower cervical spinal cord injuries (cSCI). The study objective was to define different clinical manifestations of cSCI. Data were collected prospectiv ...
Full textOpen AccessLink to itemCite
Journal ArticleJ Neurosurg Spine · August 1, 2023
OBJECTIVE: Circumferential minimally invasive surgery (cMIS) may provide incremental benefits compared with open surgery for patients with increasing frailty status by decreasing peri- and postoperative complications. METHODS: Operative patients with adult ...
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Journal ArticleAsian Spine J · August 2023
STUDY DESIGN: Retrospective cohort study. PURPOSE: To characterize the postoperative outcomes and economic costs of anterior cervical discectomy and fusion (ACDF) procedures using synthetic biomechanical intervertebral cage (BC) and structural allograft (S ...
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Journal ArticleJ Neurosurg Spine · July 1, 2023
OBJECTIVE: Depression and anxiety are associated with inferior outcomes following spine surgery. In this study, the authors examined whether patients with cervical spondylotic myelopathy (CSM) who have both self-reported depression (SRD) and self-reported ...
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Journal ArticleJ Neurosurg Spine · July 1, 2023
OBJECTIVE: Management of adult spinal deformity (ASD) has increasingly favored operative intervention; however, the incidence of complications and reoperations is high, and patients may fail to achieve idealized postsurgical results. This study compared he ...
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Journal ArticleJ Spine Surg · June 30, 2023
BACKGROUND: Enterothecal fistulas are pathological connections between the gastrointestinal system and subarachnoid space. These rare fistulas occur mostly in pediatric patients with sacral developmental anomalies. They have yet to be characterized in an a ...
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Journal ArticleBr J Neurosurg · June 2023
BACKGROUND: Neurofibromatosis type 1 (NF1) is a multisystem disorder that causes multiple tumor formations throughout the nervous system. Common spinal dysplasias seen with NF1, such as dural ectasia (DE), often undergo modulation and predispose these pati ...
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Journal ArticleWorld Neurosurg · May 2023
BACKGROUND: We developed a spinal deformity complexity checklist (SDCC) to assess the difficulty in performing a circumferential minimally invasive surgery (MIS) for adult spinal deformity. METHODS: A modified Delphi method of panel experts was used to con ...
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Journal ArticleJ Neurosurg Spine · May 1, 2023
OBJECTIVE: Patient-reported outcomes (PROs) have become the standard means to measure surgical outcomes. Insurers and policy makers are also increasingly utilizing PROs to assess the value of care and measure different aspects of a patient's condition. For ...
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Journal ArticleJ Neurosurg Spine · May 1, 2023
OBJECTIVE: Return to work (RTW) is an important surgical outcome for patients who are employed, yet a significant number of patients with cervical spondylotic myelopathy (CSM) who are employed undergo cervical spine surgery and fail to RTW. In this study, ...
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Journal ArticlePharmaceut Med · May 2023
Clinical experts are embracing the use of social media platforms for medical education, outreach, data sharing, and content dissemination within the medical community. In this interview, Dr. Khoi Than, a specialist in minimally invasive spinal surgery expl ...
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Journal ArticleWorld Neurosurg · April 2023
BACKGROUND: The accuracy of pedicle screws placed with instrument tracking and robotic navigation are individually comparable or superior to placement using standard fluoroscopy, however head-to-head comparisons between these adjuncts in a similar surgical ...
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Journal ArticleClin Spine Surg · April 1, 2023
STUDY DESIGN: Prospective observational study, level of evidence 1 for prognostic investigations. OBJECTIVES: To evaluate the prevalence of sleep impairment and predictors of improved sleep quality 24 months postoperatively in cervical spondylotic myelopat ...
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Journal ArticlePain Med · March 1, 2023
OBJECTIVE: High-impact chronic pain (HICP) is a term that characterizes the presence of a severe and troubling pain-related condition. To date, the prevalence of HICP in lumbar spine surgery recipients and their HICP transitions from before to after surger ...
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Journal ArticleJ Neurosurg Spine · March 1, 2023
OBJECTIVE: Patients who undergo surgery for cervical spondylotic myelopathy (CSM) will occasionally develop postoperative neck pain that was not present preoperatively, yet the incidence of this phenomenon is unclear. The authors aimed to elucidate patient ...
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Journal ArticleSpine (Phila Pa 1976) · March 1, 2023
STUDY DESIGN: Delphi method. OBJECTIVE: To gain consensus on the following questions: (1) When should anticoagulation/antiplatelet (AC/AP) medication be stopped before elective spine surgery?; (2) When should AC/AP medication be restarted after elective sp ...
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Journal ArticleJ Neurosurg Spine · January 1, 2023
OBJECTIVE: The aim of this study was to determine whether multilevel anterior cervical discectomy and fusion (ACDF) or posterior cervical laminectomy and fusion (PCLF) is superior for patients with cervical spondylotic myelopathy (CSM) and high preoperativ ...
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Journal ArticleSpine Deform · January 2023
PURPOSE: To determine the proportions of patients returning to work at various points after adult spinal deformity (ASD) surgery and the associations between surgical invasiveness and time to return to work. METHODS: Using a multicenter database of patient ...
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Journal ArticleWorld Neurosurg · January 2023
The prone lateral transpsoas approach for lumbar interbody fusion and posterior instrumentation enables a large surface area implant without disruption of the posterior spine musculature from a single position.1,2 The addition of virtual live fluoroscopy i ...
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Journal ArticleNeurosurg Focus · January 2023
OBJECTIVE: The authors sought to analyze the current literature to determine dimensional trends across the lumbar levels of Kambin's triangle, clarify the role of imaging techniques for preoperative planning, and understand the effect of inclusion of the s ...
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Chapter · January 1, 2023
With improvements in health care and life expectancy, the number of elderly patients pursuing spine care is increasing. Compared to younger patients, the elderly population often presents with more comorbidities and natural physiologic changes that occur w ...
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Journal ArticleNeurosurgery · December 1, 2022
BACKGROUND: The modified Japanese Orthopedic Association (mJOA) score is a widely used and validated metric for assessing severity of myelopathy. Its relationship to functional and quality-of-life outcomes after surgery has not been fully described. OBJECT ...
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Journal ArticleJ Bone Joint Surg Am · November 2, 2022
BACKGROUND: Three-column osteotomies (3COs), usually in the form of pedicle subtraction or vertebral column resection, have become common in adult spinal deformity surgery. Although a powerful tool for deformity correction, 3COs can increase the risks of p ...
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Journal ArticleJ Neurosurg Spine · November 1, 2022
Dr. Ruth Jackson, born in 1902, was the first female spine surgeon on record. Her story of remarkable resilience and sacrifice is even more relevant given the stark gender disparities in orthopedic surgery and neurosurgery that remain today. Dr. Jackson en ...
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Journal ArticleJ Neurosurg Spine · November 1, 2022
OBJECTIVE: While surgical decompression is an important treatment modality for cervical spondylotic myelopathy (CSM), it remains unclear if the severity of preoperative myelopathy status affects potential benefit from surgical intervention and when maximum ...
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Journal ArticleJ Neurosurg Spine · September 1, 2022
OBJECTIVE: Cervical spondylotic myelopathy (CSM) is a common progressive spine disorder affecting predominantly middle-aged and elderly populations. With increasing life expectancy, the incidence of CSM is expected to rise further. The outcomes of elderly ...
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Journal ArticleEur Spine J · September 2022
PURPOSE: Prone transpsoas fusion (PTP) is a minimally invasive technique that maximizes the benefit of lateral access interbody surgery and the prone positioning for surgically significant adjacent segment disease. The authors describe the feasibility, rep ...
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Journal ArticleJ Neurosurg Spine · August 1, 2022
OBJECTIVE: Minimally invasive surgery (MIS) for adult spinal deformity (ASD) can offer deformity correction with less tissue manipulation and damage. However, the impact of obesity on clinical outcomes and radiographic correction following MIS for ASD is p ...
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Journal ArticleSpine (Phila Pa 1976) · July 15, 2022
STUDY DESIGN: Retrospective cohort review of a prospective multicenter database. OBJECTIVE: Identify rates and variations in lumbopelvic fixation failure after adult spinal deformity (ASD) correction. SUMMARY OF BACKGROUND DATA: Traditional iliac (IS) and ...
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Journal ArticleJ Neurosurg Spine · July 1, 2022
OBJECTIVE: High-impact chronic pain (HICP) is a recently proposed metric that indicates the presence of a severe and troubling pain-related condition. Surgery for cervical spondylotic myelopathy (CSM) is designed to halt disease transition independent of c ...
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Journal ArticleJ Neurosurg Spine · July 1, 2022
OBJECTIVE: Combinations of certain social risk factors of race, sex, education, socioeconomic status (SES), insurance, education, employment, and one's housing situation have been associated with poorer pain and disability outcomes after lumbar spine surge ...
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ConferenceOper Neurosurg (Hagerstown) · July 1, 2022
BACKGROUND: Patients undergoing sacroiliac (SI) fusion can oftentimes experience significant improvements in pain and quality of life. OBJECTIVE: To describe a novel application of robotic navigation to assist with minimally invasive SI joint fusion. METHO ...
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Journal ArticleWorld Neurosurg · July 2022
OBJECTIVE: Distance learning has become increasingly important to expand access to neurosurgical spine education. However, emerging online spine education initiatives have largely focused on residents, fellows, and surgeons in practice. We aimed to assess ...
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Journal ArticleNeurosurg Focus Video · July 2022
In this video, the authors highlight the operative treatment of a 55-year-old man with chronic osteomyelitis discitis. The operation entailed a minimally invasive lateral retroperitoneal transpsoas approach for L3 and L4 corpectomies, L2-5 interbody fusion ...
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Journal ArticleWorld Neurosurg · June 2022
In recent years, physicians and institutions have come to recognize the increasing opioid epidemic in the United States, thus prompting a dramatic shift in opioid prescribing patterns. The lack of well-studied alternative treatment regimens has led to a su ...
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Journal ArticleJournal of Neurosurgery: Spine · May 1, 2022
OBJECTIVE Traditional surgery for adult spinal deformity (ASD) is effective but may result in exposure-related morbidity. Minimally invasive surgery (MIS) can potentially minimize this morbidity; however, high-level evidence is lacking. This study presents ...
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Journal ArticleJ Neurosurg Spine · April 1, 2022
OBJECTIVE: Minimally invasive surgery (MIS) techniques can effectively stabilize and decompress many thoracolumbar injuries with decreased morbidity and tissue destruction compared with open approaches. Nonetheless, there is limited direction regarding the ...
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Journal ArticleJ Neurosurg Spine · April 1, 2022
OBJECTIVE: Previous studies have demonstrated the short-term radiographic and clinical benefits of circumferential minimally invasive surgery (cMIS) and hybrid (i.e., minimally invasive anterior or lateral interbody fusion with an open posterior approach) ...
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Journal ArticleJ Neurosurg Spine · April 1, 2022
OBJECTIVE: Degenerative cervical myelopathy (DCM) results in significant morbidity. The duration of symptoms prior to surgical intervention may be associated with postoperative surgical outcomes and functional recovery. The authors' objective was to invest ...
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Journal ArticleJ Neurosurg Spine · February 1, 2022
OBJECTIVE: Circumferential minimally invasive spine surgery (cMIS) for adult scoliosis has become more advanced and powerful, but direct comparison with traditional open correction using prospectively collected data is limited. The authors performed a retr ...
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Journal ArticleOper Neurosurg (Hagerstown) · February 1, 2022
Posterior cervical decompression and fusion is an effective strategy for correction of cervical spondylotic myelopathy. Here, we highlight the operative treatment of a 63-yr-old man entailing a 4-level posterior cervical laminectomy and fusion, with the us ...
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Journal ArticleFront Surg · 2022
Interest in robotic-assisted spine surgery has grown as surgeon comfort and technology has evolved to maximize benefits of time saving and precision. However, the Food and Drug Administration (FDA) has currently only approved robotics to assist in determin ...
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Chapter · January 1, 2022
In this chapter, Dr. Than discusses the journey of finding a new job and ensuring that the position is the right fit for you. Do not start the job search too early. For academics, 1 year ahead of time is the sweet spot. Cast a wide net. The most common res ...
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Journal ArticleJ Clin Neurosci · December 2021
Robotic navigation is a new and rapidly emerging niche within minimally invasive spine surgery. The robotic arms-race began in 2004 and has resulted in no less than four major robotic surgical adjuncts. Current Food and Drug Administration (FDA)-approved a ...
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Journal ArticleOper Neurosurg (Hagerstown) · November 15, 2021
BACKGROUND: Minimally invasive spine surgery (MISS) has the potential to further advance with the use of robot-assisted (RA) techniques. While RA pedicle screw placement has been extensively investigated, there is a lack of literature on the use of the rob ...
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Journal ArticleActa Neurochir (Wien) · November 2021
BACKGROUND: Robotic-assisted surgery is becoming more widely applied in surgical subspecialties due to its intraoperative and postoperative advantages such as minimally invasive approach, reduced blood loss, shorter hospital stay, and decreased incidence o ...
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Journal ArticleJ Am Coll Radiol · November 2021
Plexopathy may be caused by diverse pathologies, including trauma, nerve entrapment, neoplasm, inflammation, infection, autoimmune disease, hereditary disease, and idiopathic etiologies. For patients presenting with brachial or lumbosacral plexopathy, dedi ...
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Journal ArticleOper Neurosurg (Hagerstown) · August 16, 2021
Minimally invasive lumbar laminectomies utilize tubular retractors to minimize tissue disturbance, blood loss, and hospital length of stay compared to open operations. Here, we highlight the operative treatment of a 68-yr-old male entailing a 2-level minim ...
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Journal ArticleOper Neurosurg (Hagerstown) · August 16, 2021
Front-back procedures for cervical deformity permit the correction of cervical kyphosis in the setting of unfused facets. Here, we highlight the operative treatment of a 65-yr-old female entailing a 4-level anterior cervical discectomy and fusion (ACDF) at ...
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Journal ArticleWorld Neurosurg · August 2021
BACKGROUND: Minimally invasive surgical techniques have resulted in improved patient outcomes. One drawback has been the increased reliance on fluoroscopy and subsequent exposure to ionizing radiation. We have previously shown the efficacy of a novel instr ...
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Journal ArticleJ Neurosurg Spine · August 1, 2021
OBJECTIVE: The rate of symptomatic adjacent-segment disease (ASD) after newer minimally invasive techniques, such as lateral lumbar interbody fusion (LLIF), is not known. This study aimed to assess the incidence of surgically significant ASD in adult patie ...
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Journal ArticleOper Neurosurg (Hagerstown) · June 15, 2021
Spinal fusion has undergone significant evolution and improvement over the past 50 yr. Historically, spine fusion was noninstrumented and arthrodesis was based entirely on autograft. Improved understanding of spinal anatomy and materials science ushered in ...
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Journal ArticleJ Neurosurg Spine · June 1, 2021
OBJECTIVE: Patients with nonoperative (N-Op) adult spinal deformity (ASD) have inferior long-term spinopelvic alignment and clinical outcomes. Predictors of lower quality-of-life measures in N-Op populations have yet to be sufficiently investigated. The ai ...
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Journal ArticleNeurosurg Focus · June 2021
OBJECTIVE: The use of osteobiologics, engineered materials designed to promote bone healing by enhancing bone growth, is becoming increasingly common for spinal fusion procedures, but the efficacy of some of these products is unclear. The authors performed ...
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Journal ArticleJ Neurosurg Spine · May 1, 2021
OBJECTIVE: Minimally invasive surgery (MIS) for spinal deformity uses interbody techniques for correction, indirect decompression, and arthrodesis. Selection criteria for choosing a particular interbody approach are lacking. The authors created the minimal ...
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Journal ArticleNeurosurg Focus · May 2021
OBJECTIVE: In patients with metastatic spinal disease (MSD), interhospital transfer can potentially impact clinical outcomes as the possible benefits of transferring a patient to a higher level of care must be weighed against the negative effects associate ...
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Journal ArticleWorld Neurosurg · April 2021
BACKGROUND: Spinopelvic parameters have hitherto dictated much of adult spinal deformity (ASD) correction. The Roussouly classification is used for the normal adult spine. We evaluated whether a correlation would be found between the Roussouly type and the ...
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Journal ArticleClin Neurol Neurosurg · January 2021
BACKGROUND CONTEXT: Preoperative optimization of medical comorbidities prior to spinal surgery is becoming an increasingly important intervention in decreasing postoperative complications and ensuring a satisfactory postoperative course. The treatment of p ...
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Journal ArticleJ Clin Neurosci · January 2021
STUDY DESIGN: Literature review. OBJECTIVES: It has been reported that 2.4-3.7% of all blunt trauma victims suffer some element of cervical spine fracture, with the majority of these patients suffering from C3-7 (subaxial) involvement. With the improvement ...
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Journal ArticleFront Surg · 2021
Traumatic spinal cord injury (TSCI) is a debilitating disease that poses significant functional and economic burden on both the individual and societal levels. Prognosis is dependent on the extent of the spinal injury and the severity of neurological dysfu ...
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Journal ArticleJ Neurosurg Spine · November 1, 2020
OBJECTIVE: Surgical decision-making and planning is a key factor in optimizing outcomes in adult spinal deformity (ASD). Minimally invasive spinal (MIS) strategies for ASD have been increasingly used as an option to decrease postoperative morbidity. This s ...
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Journal ArticleNeurosurg Focus · November 2020
Spine surgery has been disproportionately impacted by medical liability and malpractice litigation, with the majority of claims and payouts related to procedural error. One common area for the potential avoidance of malpractice claims and subsequent payout ...
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Journal ArticleWorld Neurosurg · August 2020
BACKGROUND: The coronavirus identified in 2019 (COVID-19) pandemic effectively ended all major spine educational conferences in the first half of 2020. In response, the authors formed a "virtual" case-based conference series directed at delivering spine ed ...
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Journal ArticleWorld Neurosurg · July 2020
Split cord malformation (SCM) is a developmental disorder that is usually symptomatic and diagnosed in childhood. The majority of these lesions are in the thoracic and lumbar spine, with only 1%-3% of cases found in the cervical spine. This is a case repor ...
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Journal ArticleSpine (Phila Pa 1976) · July 1, 2020
STUDY DESIGN: Expert opinion-modified Delphi study. OBJECTIVE: We used a modified Delphi approach to obtain consensus among leading spinal deformity surgeons and their neuroanesthesiology teams regarding optimal practices for obtaining reliable motor evoke ...
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Journal ArticleInterdisciplinary Neurosurgery: Advanced Techniques and Case Management · June 1, 2020
Awake surgeries are commonly performed in many specialties through the use of local or regional anesthesia. These methods avoid the risks associated with general endotracheal anesthesia and allow faster recovery times. In neurosurgery, awake surgeries are ...
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Journal ArticleJ Neurosurg Spine · May 1, 2020
OBJECTIVE: Common interbody graft options for anterior cervical discectomy and fusion (ACDF) include allograft and polyetheretherketone (PEEK). PEEK has gained popularity due to its radiolucent properties and a modulus of elasticity similar to that of bone ...
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Journal ArticleJ Am Coll Radiol · May 2020
Although primary bone tumors are relatively uncommon, appropriate imaging evaluation is essential when they are suspected or incidentally detected. In almost all cases, radiographs are the most appropriate initial imaging study for screening and characteri ...
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Journal ArticleJ Clin Neurosci · April 2020
BACKGROUND: Bone growth stimulators have been used as an adjunct to spinal fusion surgery in efforts to increase fusion rates. METHODS: The authors retrospectively reviewed the medical records of patients who underwent thoracolumbar fusion surgeries by a s ...
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Journal ArticleJ Neurosurg Spine · February 1, 2020
OBJECTIVE: Minimally invasive surgery (MIS) can be used as an alternative or adjunct to traditional open techniques for the treatment of patients with adult spinal deformity. Recent advances in MIS techniques, including advanced anterior approaches, have i ...
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Journal ArticleJ Clin Neurosci · January 2020
BACKGROUND: Intraoperative neuromonitoring is a common, well-established modality used in spine surgery to prevent intraoperative neural injury. Neuromonitoring use in lumbar discectomy, however, is based on surgeon preference, without evidence-based data. ...
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Journal ArticleNeurosurg Clin N Am · January 2020
Adult spinal deformity is a major contributor to pain and disability. It is a degenerative disease with a rigid spine. Spinopelvic parameters have been identified that outline goals of operative intervention, as they have shown to significantly improve pat ...
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Journal ArticleJ Neurosurg Spine · December 1, 2019
OBJECTIVE: The past decade has seen major advances in techniques for treating more complex spinal disorders using minimally invasive surgery (MIS). While appealing from the standpoint of patient perioperative outcomes, a major impediment to adoption has be ...
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Journal ArticleBr J Neurosurg · October 2019
Object: IgG4-related disease (IgG4-RD) is a fibro-inflammatory disorder affecting various anatomical sites, and only recently was identified to affect the dura of the spine. The authors present the second reported case of an intradural extramedullary lesio ...
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Journal ArticleJ Neurosurg · October 1, 2019
OBJECTIVE: Gastrostomy tube placement can temporarily seed the peritoneal cavity with bacteria and thus theoretically increases the risk of shunt infection when the two procedures are performed contemporaneously. The authors hypothesized that gastrostomy t ...
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Journal ArticleJ Spine Surg · September 2019
BACKGROUND: Lung cancer is the most common source of spinal metastases. As our treatment of spinal metastases evolves, national trends in radiation therapy (RT), including spinal stereotactic neurosurgery, have yet to been established. METHODS: We performe ...
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Journal ArticleJ Neurosurg Spine · June 1, 2019
OBJECTIVE: It is now well accepted that spinopelvic parameters are correlated with clinical outcomes in adult spinal deformity (ASD). The purpose of this study was to determine whether obtaining optimal spinopelvic alignment was absolutely necessary to ach ...
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Journal ArticleWorld Neurosurg · June 2019
BACKGROUND: Spinal deformity surgery is often invasive and lengthy. Staging surgery over separate operative days may reduce complications. Staging is often used in minimally invasive treatment of adult spinal deformity (ASD). OBJECTIVE: To investigate the ...
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Journal ArticleJ Am Coll Radiol · May 2019
Injuries to the cervical and thoracolumbar spine are commonly encountered in trauma patients presenting for treatment. Cervical spine injuries occur in 3% to 4% and thoracolumbar fractures in 4% to 7% of blunt trauma patients presenting to the emergency de ...
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Journal ArticlePhys Sportsmed · May 2019
INTRODUCTION: Sports surveillance databases provide valuable information regarding common ailments, yet fewer studies have focused on more rare peripheral nerve injuries. Our objective was to characterize peripheral nerve injuries in high school athletics ...
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Journal ArticleWorld Neurosurg · March 2019
The Young Neurosurgeons Committee, founded in 1991 by Dr. Roberto C. Heros, has been a vital component of the American Association of Neurological Surgeons. It has grown from an opportunity for young neurosurgeons to network with senior neurosurgeons to be ...
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Journal ArticleWorld Neurosurg · February 2019
BACKGROUND: Adult spinal deformity (ASD) operations are complex and often require a multisurgeon team. Simultaneously, it is the responsibility of academic spine surgeons to train future complex spine surgeons. Our objective was to assess the effect of res ...
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Journal ArticleBr J Neurosurg · February 2019
Surgical treatment for high-grade spondylolisthesis with high sacral slope remains controversial and no definitive gold standard procedure has been identified. The Bohlman technique, in which a fibular strut is reamed posteriorly across the L5-S1 disc spac ...
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Journal ArticleJ Neurosurg Spine · January 1, 2019
In BriefThe authors examined fusion rates after single-level anterior cervical discectomy and fusion, comparing use of a structural allograft with use of polyetheretherketone (PEEK) interbody devices packed with bone graft. The results demonstrate superior ...
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Journal ArticleJ Craniovertebr Junction Spine · 2019
HYPOTHESIS: Reciprocal changes in the upper cervical spine correlate with adult TL deformity modifiers. DESIGN: This was a retrospective review. INTRODUCTION: The upper cervical spine has remarkable adaptability to wide ranges of thoracolumbar (TL) deformi ...
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Journal ArticleGlobal Spine J · December 2018
STUDY DESIGN: Retrospective, multicenter review of adult scoliosis patients with minimum 2-year follow-up. OBJECTIVE: Because the fractional curve (FC) of adult scoliosis can cause radiculopathy, we evaluated patients treated with either circumferential mi ...
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Journal ArticleJ Neurosurg Spine · November 1, 2018
OBJECTIVEAchieving appropriate spinopelvic alignment in deformity surgery has been correlated with improvement in pain and disability. Minimally invasive surgery (MIS) techniques have been used to treat adult spinal deformity (ASD); however, there is conce ...
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ConferenceNeurosurgery · August 1, 2018
BACKGROUND: Pelvic tilt (PT) is a compensatory mechanism for adult spinal deformity patients to mitigate sagittal imbalance. The association between preop PT and postop clinical and radiographic outcomes has not been well studied in patients undergoing min ...
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Journal ArticleAsian Spine J · June 2018
STUDY DESIGN: A literature review. PURPOSE: To explore the utility of laminoplasty in combination with instrumented fusion, with a focus on neurological outcomes and changes in kyphotic deformity. OVERVIEW OF LITERATURE: Management of cervical spondylotic ...
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Journal ArticleJ Clin Neurosci · February 2018
PURPOSE: The authors present a holospinal epidural abscesses (HEA) case series and a single institution's experience with varied surgical approaches and outcomes. METHODS: Medical records were queried and reviewed (6 years) for patients with a spinal absce ...
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Journal ArticleNeurosurg Focus · December 2017
OBJECTIVE High-quality studies that compare outcomes of open and minimally invasively placed pedicle screws for adult spinal deformity are needed. Therefore, the authors compared differences in complications from a circumferential minimally invasive spine ...
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ConferenceJ Neurosurg Spine · November 2017
OBJECTIVE Cervical curvature is an important factor when deciding between laminoplasty and laminectomy with posterior spinal fusion (LPSF) for cervical spondylotic myelopathy (CSM). This study compares outcomes following laminoplasty and LPSF in patients w ...
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Journal ArticleSpine (Phila Pa 1976) · October 3, 2017
STUDY DESIGN: Prospectively-collected survey study OBJECTIVE.: To determine the consistency with which spino-pelvic parameters (SPP) are determined in patients with lumbosacral transitional vertebrae (LSTV). SUMMARY OF BACKGROUND DATA: The incidence of LST ...
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Journal ArticleJ Neurosurg Spine · August 2017
Pseudogout is a form of acute calcium pyrophosphate deposition (CPPD) disease that typically afflicts the elderly. CPPD commonly involves larger joints, such as the knees, wrists, shoulders, and hips, and has been known to involve the spine. The authors re ...
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Journal ArticleSpine (Phila Pa 1976) · June 6, 2017
STUDY DESIGN: Reliability study of radiographic measures of proximal junctional kyphosis in adult spinal deformity patients. OBJECTIVE: Assess impacts of level of proximal endpoint and vertebral fracture on reliability of measurement of junctional kyphosis ...
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Journal ArticleJ Am Coll Radiol · May 2017
MRI without and with contrast is the most accurate imaging method to determine whether a process is intrinsic or extrinsic to a nerve of the brachial or lumbosacral plexus. However, there are no Current Procedural Terminology codes to correspond to imaging ...
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Journal ArticleGlobal Spine J · April 2017
STUDY DESIGN: A multicenter, retrospective review of C5 palsy after cervical spine surgery. OBJECTIVE: Postoperative C5 palsy is a known complication of cervical decompressive spinal surgery. The goal of this study was to review the incidence, patient char ...
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Journal ArticleGlobal Spine J · April 2017
STUDY DESIGN: Retrospective multicenter case series study. OBJECTIVE: Because cervical dural tears are rare, most surgeons have limited experience with this complication. A multicenter study was performed to better understand the presentation, treatment, a ...
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Journal ArticleGlobal Spine J · April 2017
STUDY DESIGN: This study was a retrospective, multicenter cohort study. OBJECTIVES: Rare complications of cervical spine surgery are inherently difficult to investigate. Pseudomeningocoele (PMC), an abnormal collection of cerebrospinal fluid that communica ...
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Journal ArticleGlobal Spine J · April 2017
STUDY DESIGN: Retrospective, multicenter case-series study and literature review. OBJECTIVES: To determine the prevalence of brachial plexopathy after cervical spine surgery and to review the literature to better understand the etiology and risk factors of ...
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Journal ArticleClin Neurol Neurosurg · March 2017
Spinal cord hemangioblastomas are benign vascular tumors arising sporadically in approximately 70-80% of cases. They can also be manifestations of von Hippel-Lindau (VHL) disease, as these patients will often have multiple spinal hemangioblastomas. Histori ...
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Chapter · January 1, 2017
Management of cervical spinal infections is a frequent problem encountered by spine surgeons. While categorized as a single disease process, cervical infections are, in reality, a combination of two separate issues: treatment of infected tissues (consistin ...
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ConferenceJ Neurosurg Spine · August 2016
OBJECTIVE To date, the factors that predict whether a patient returns to work after lumbar discectomy are poorly understood. Information on postoperative work status is important in analyzing the cost-effectiveness of the procedure. METHODS An observationa ...
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Journal ArticleNeurosurgery · August 1, 2016
RESULTS: Of 420 patients that met inclusion criteria, 165 had complete data. One hundred thirty-seven were available for analysis after excluding 3 column osteotomies and 76 remained after propensity matching (38 cMIS and 38 HYB). There were no differences ...
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Journal ArticleNeurosurgery · August 1, 2016
INTRODUCTION: Cervical curvature is an important factor when deciding between laminoplasty or laminectomy with posterior spinal fusion (PSF). This study compares outcomes of laminoplasty and laminectomy with PSF in patients with matched regional sagittal b ...
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Journal ArticleJ Neurosurg Spine · July 2016
OBJECTIVE Minimally invasive surgery (MIS) techniques are increasingly used to treat adult spinal deformity. However, standard minimally invasive spinal deformity techniques have a more limited ability to restore sagittal balance and match the pelvic incid ...
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Journal ArticleJ Clin Neurosci · May 2016
Nocardia species are an infrequent cause of brain abscesses. We report a 50-year-old man with Nocardia paucivorans cerebral abscesses. Brain MRI revealed innumerable small ring-enhancing lesions. The patient initially responded to treatment with antibiotic ...
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Journal ArticleWorld Neurosurg · February 2016
BACKGROUND: Older age has been considered a relative contraindication to complex spinal procedures. Minimally invasive surgery (MIS) techniques to treat patients with adult spinal deformity (ASD) have emerged with the potential benefit of decreased approac ...
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Journal ArticleNeurosurgery · October 2015
Surgical management of spinal deformity is elderly patients is characterized by significant variability. In a value-based health care economy, minimization of risks and maximization of benefit and durability of surgery are a priority. The choice of a surgi ...
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Journal ArticleNeurosurg Focus · August 2015
OBJECT Spinal tumor resection has historically been performed via open approaches, although minimally invasive approaches have recently been found to be effective in small cohort series. The authors compare surgical characteristics and clinical outcomes of ...
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Journal ArticleJ Cancer Res Clin Oncol · June 2015
PURPOSE: We have previously shown that BMP-2 induces bone formation and inhibits tumorigenicity of cancer stem cells (CSCs) in a human osteosarcoma OS99-1 cell line. In this study, we sought to determine whether BMP-2 can similarly induce bone formation an ...
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Journal ArticleEur Spine J · May 2015
PURPOSE: Expandable cages are a more recent option for maintaining or restoring disc height and segmental lordosis with transforaminal lumbar interbody fusion (TLIF). Complications associated with expandable cages have not yet been widely reported. We repo ...
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Journal ArticleWorld Neurosurg · December 2014
BACKGROUND: Ionizing radiation is typically used during spine surgery for localization and guidance in instrumentation placement. Minimally invasive (MI) surgical procedures are increasingly popular and often require significantly more fluoroscopy, placing ...
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Journal ArticleWorld Neurosurg · December 2014
OBJECTIVE: With subspecialty surgical care often unavailable to poor patients in developing countries, short-term brigades have filled a portion of the gap. We prospectively assessed the cost effectiveness of a pediatric neurosurgical brigade to Guatemala ...
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Journal ArticleWorld Neurosurg · November 2014
BACKGROUND: Clinically significant intratumoral hemorrhage historically has been reported in only a small fraction of vestibular schwannomas (VS). Patients with hemorrhagic VS are more likely to present with neurologic deficits and have worse outcomes than ...
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Journal ArticleJ Clin Neurosci · July 2014
In the USA, obesity rates have significantly increased in the last 15 years. Mirroring this trend, a large proportion of patients undergoing spinal surgery are obese. Concern exists for increased complications due to surgical challenges posed by obese pati ...
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Journal ArticleSpine J · June 1, 2014
BACKGROUND CONTEXT: A large percentage of back pain can be attributed to degeneration of the intervertebral disc (IVD). Bone morphogenetic protein 2 (BMP-2) is known to play an important role in chondrogenesis of the IVD. Simvastatin is known to upregulate ...
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Journal ArticleEur Spine J · March 2014
PURPOSE: Sleep apnea is a multi-factorial disease with a variety of identified causes. With its close proximity to the upper airway, the cervical spine and its associated pathologies can produce sleep apnea symptoms in select populations. The aim of this a ...
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Journal ArticleActa Neurochir (Wien) · February 2014
BACKGROUND: Local recurrence of spinal metastasis after surgical resection is relatively common. We sought to determine risk factors and independent predictors for local recurrence after primary surgical resection of spinal metastasis. METHODS: Demographic ...
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Chapter · January 1, 2014
Minimally invasive approaches allow surgeons to achieve clinical outcomes similar to traditional open approaches but with decreased blood loss, postoperative pain, and length of hospital stay. In 1998, a minimally invasive retroperitoneal transpsoas approa ...
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Journal ArticleIEEE Trans Biomed Eng · January 2014
The primary objective of our study was to develop a thermoelectrical model with both solid and liquid phases to calculate tissue temperature during bipolar coagulation of a posterior spinal artery on the spinal cord. Control of thermal spread caused by coa ...
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Journal ArticleInt J Oncol · October 2013
Our previous studies demonstrated that BMP-2 inhibits the tumorigenicity of cancer stem cells identified as cells with high aldehyde dehydrogenase activity (ALDH(br) cells) from the human osteosarcoma cell line OS99-1. We further investigated whether BMP-2 ...
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Journal ArticleSpine J · August 2013
BACKGROUND CONTEXT: Human recombinant bone morphogenetic protein-2 (BMP-2) is commonly used in spinal surgery to augment arthrodesis, and a number of potential complications have been documented. PURPOSE: To present the case of a delayed radiculopathy that ...
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Journal ArticleNeurosurg Focus · July 2013
This video describes a minimally invasive approach for treatment of symptomatic grade I spondylolisthesis and high-grade spinal stenosis. In this procedure, a unilateral approach for bilateral decompression is utilized in conjunction with a modified transf ...
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Journal ArticleNeurosurg Focus · July 2013
This video details a minimally invasive treatment of symptomatic adult kyphoscoliosis. Both anterior and posterior approaches are used to obtain sagittal and coronal balance. In addition, improved lumbar lordosis is achieved to closely match the patient's ...
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Journal ArticleJ Neurosurg · July 2013
OBJECT: The middle cranial fossa (MCF) approach is a microsurgical technique described as a primary option in the treatment of small, intracanalicular schwannomas involving the eighth cranial nerve. Excellent rates of complete tumor resection, hearing pres ...
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Journal ArticleEur Spine J · June 2013
PURPOSE: Surgery for spinal metastasis is often associated with significant morbidity. Despite a number of preoperative scoring systems/scales and identified variables that have been reported to predict complication risk, clinical studies that directly eva ...
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Journal ArticleAAPS J · April 2013
Simvastatin (SIM), a drug commonly administered for the treatment of hypercholesterolemia, has been recently reported to induce bone regeneration/formation. In this study, we investigated the properties of hydrogel composed of gelatin-poly(ethylene glycol) ...
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Journal ArticleJ Clin Neurosci · January 2013
The management of spinal vascular malformations (SVM) has improved over the last four decades with the evolution of imaging, anesthesia, microsurgery, and endovascular techniques. Commonly used high-resolution imaging techniques include CT angiography, mag ...
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Journal ArticleSurg Neurol Int · 2013
BACKGROUND: Coagulation accomplished using bipolar forceps is common in neurosurgery. Control of thermal spread from the forceps tips into surrounding neural tissues is a persistent concern, as neural tissues are especially vulnerable to heat injury. The p ...
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Journal ArticleSurg Neurol Int · 2013
BACKGROUND: Pneumatized anterior clinoid process is a common anatomic variant. Mucocele formation is a known complication of clinoid drilling during certain intracranial operations; however, mucoceles of pneumatized anterior clinoid processes have been fou ...
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Journal ArticleEur Spine J · November 2012
INTRODUCTION: First described in 1927, a Schmorl's node (SN) is the herniation of nucleus pulposus (NP) through the cartilaginous and bony end plate into the body of the adjacent vertebra. SNs are common findings on imaging, and although most SNs are asymp ...
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Journal ArticleInt J Cancer · October 15, 2012
Bone morphogenetic protein-2 (BMP-2), a member of the transforming growth factor superfamily, has been shown to have inhibitory effect on many tumor types. However, the effect of BMP-2 on human renal cell carcinoma (RCC) is still unknown. We previously sho ...
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Journal ArticleJ Clin Neurosci · September 2012
In patients who undergo neurovascular stent placement with postoperative dual antiplatelet therapy to prevent in-stent thrombosis, there is no protocol for balancing the risk of acute stent thrombosis and bleeding if urgent neurosurgical procedures are req ...
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Journal ArticleJ Clin Neurosci · July 2012
The overwhelming majority of pineal region tumors are malignant germ cell tumors, pineal cell tumors, or glial tumors. To our knowledge we report the first patient with myeloid sarcoma in the pineal region. Myeloid sarcomas are composed of immature granulo ...
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Journal ArticleJ Trauma Acute Care Surg · June 2012
BACKGROUND: Digital subtraction angiography (DSA) is the gold standard for radiographic diagnosis of blunt cerebrovascular injury (BCVI), but use of computed tomography angiography (CTA) and magnetic resonance angiography (MRA) has increased dramatically i ...
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Journal ArticleJ Clin Neurosci · June 2012
There is currently no reproducible animal model of renal cell carcinoma (RCC) spinal metastasis that allows for laboratory study of the human disease. In this report, we describe an animal model that reliably reproduces RCC spinal metastasis using a human ...
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Journal ArticleNeurosurgery · April 2012
Bone morphogenetic proteins (BMPs) are involved not only in osteogenesis but also in chondrogenesis. They play an important role in the development and maintenance of the intervertebral disk (IVD). For this reason, an increasing amount of research has been ...
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Journal ArticleNeurosurg Focus · December 2011
The primary aim of our study was to provide a comprehensive review of the clinical, imaging, and histopathological features of Tarlov cysts (TCs) and to report operative and nonoperative management strategies in patients with sacral TCs. A literature revie ...
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Journal ArticleJ Neurosurg Pediatr · December 2011
In this report, the authors describe the first known case of inducible hemifacial weakness in a patient with Chiari malformation Type I (CM-I). The patient was a 14-year-old girl with a 1-year history of right facial paresis induced by sustained leftward h ...
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Journal ArticleJ Neurosurg Pediatr · November 2011
Roberts/SC phocomelia syndrome (RBS) is a rare but distinct genetic disorder with an autosomal recessive inheritance pattern. It has been associated with microcephaly, craniofacial malformation, cavernous hemangioma, encephalocele, and hydrocephalus. There ...
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Journal ArticleJ Clin Neurosci · November 2011
Radiographic findings of hyperglycemic non-ketotic chorea-hemiballismus and basal ganglia hemorrhage can be highly similar. A 58-year-old female presented with a 1-week history of choreiform and ballistic movements of the left arm. Based on CT imaging, the ...
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Journal ArticleNeurosurg Focus · October 2011
The goal of this study was to review the literature to compare strategies for avoiding and treating complications from anterior lumbar interbody fusion (ALIF), and thus provide a comprehensive aid for spine surgeons. A thorough review of databases from the ...
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Journal ArticleJ Clin Neurosci · June 2011
Malignant peripheral nerve sheath tumor (MPNST) of the cauda equina is rare, with only four reported patients in the literature. We present a 70-year-old woman with a history of left sciatic nerve MPNST that had been treated by left hemipelvectomy 4 years ...
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Chapter · January 1, 2011
Intraprocedural rupture of an intracranial aneurysm is a potentially catastrophic complication, but can be even more devastating in a heparinized patient in an offsite interventional suite. Understanding how to respond to such an event is essential to good ...
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Journal ArticleJ Neurosurg Spine · January 2011
OBJECT: surgical correction of symptomatic cervical or cervicothoracic kyphosis involves the potential for significant neurological complications. Intraoperative monitoring has been shown to reduce the risk of neurological injury in scoliosis surgery, but ...
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Journal ArticleExpert Opin Med Diagn · November 2010
IMPORTANCE OF THE FIELD: Cancer resistance to conventional therapies has been attributed to cancer stem cells (CSCs). Although a variety of markers have been reported, a universal marker has not yet been found to identify CSCs. Better identification of the ...
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Journal ArticleJ Clin Neurosci · June 2010
Hürthle cell carcinoma is a rare variant of differentiated thyroid cancer that occasionally forms distant metastases. However, even in the presence of metastases, patients with Hürthle cell carcinoma have a relatively good prognosis. There are few reports ...
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Journal ArticleJ Clin Neurosci · April 2010
The trans-oral approach allows direct access to pathologies of the anterior craniocervical junction. However, the classic midline incision of the posterior pharyngeal wall can be surgically burdensome and limits lateral exposure. We reviewed the medical re ...
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Journal ArticleNeurosurg Focus · March 2010
OBJECT: Symptomatic cervical kyphosis can result from a variety of causes. Symptoms can include pain, neurological deficits, and functional limitation due to loss of horizontal gaze. METHODS: The authors review the long-term functional and radiographic out ...
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Journal ArticleNeurosurgery · February 2010
OBJECTIVE: In addition to their well-known osteogenic properties, bone morphogenetic proteins (BMPs) have developmental and regenerative roles that may impact tumorigenesis and promote tumor spread. Given that the most common site of tumor metastases to bo ...
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Journal ArticleSAS J · 2010
OBJECTIVE: To evaluate outcomes after minimally invasive transforaminal lumbar interbody fusion (MI-TLIF). BACKGROUND: MI-TLIF is a relatively novel technique for treating symptomatic spondylolisthesis and degenerative disc disease of the lumbar spine. It ...
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Journal ArticleNeurosurg Focus · October 2009
OBJECT: Transcranial motor evoked potential (TcMEP) monitoring is frequently used in complex spinal surgeries to prevent neurological injury. Anesthesia, however, can significantly affect the reliability of TcMEP monitoring. Understanding the impact of var ...
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Journal ArticleNeurosurgery · September 2009
OBJECTIVE: Balancing the benefits of extensive tumor resection with the consequence of potential postoperative deficits remains a challenge in malignant astrocytoma surgery. Although studies have suggested that increasing extent of resection may benefit su ...
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Journal ArticleSurg Neurol · March 2009
BACKGROUND: Clinical depression has been shown to negatively influence the morbidity and mortality of multiple disease states. It remains unclear if clinical depression affects survival after surgical management of malignant brain astrocytoma. We set out t ...
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Journal ArticleJ Neurosurg · March 2009
OBJECT: Gliadel (BCNU) wafer and concomitant temozolomide (TMZ) therapy, when used individually as adjuvant therapies, extend survival from that achieved by resection and radiation therapy (XRT) for glioblastoma multiforme (GBM). It remains unstudied wheth ...
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Journal ArticleJ Neurosurg · January 2009
OBJECT: With recent advances in the adjuvant treatment of malignant brain astrocytomas, it is increasingly debated whether extent of resection affects survival. In this study, the authors investigate this issue after primary and revision resection of these ...
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Journal ArticleNeurosurgery · October 2008
OBJECTIVE: It remains unknown whether the extent of surgical resection affects survival or disease progression in patients with supratentorial low-grade gliomas. METHODS: We conducted a retrospective cohort study (n = 170) between 1996 and 2007 at a single ...
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Journal ArticleMinim Invasive Neurosurg · October 2008
Unintended durotomy is a relatively common complication in spine surgery, with a reported incidence up to 14%. Traditional management has been mandatory bed rest for at least 48 h following repair, with or without placement of a drain. With the muscle-spli ...
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Journal ArticleNeurosurgery · August 2008
OBJECTIVE: Patients with malignant brain astrocytomas are at high risk for developing hyperglycemia secondary to frequent corticosteroid administration. Several clinical studies have shown that hyperglycemia is associated with poor outcome in multiple dise ...
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Journal ArticleSpine (Phila Pa 1976) · July 15, 2008
STUDY DESIGN: Literature review. OBJECTIVE: To evaluate surgical management and outcomes in the treatment of severe chin-on-chest deformities due to ankylosing spondylitis (AS). SUMMARY OF BACKGROUND DATA: AS is a chronic inflammatory disease that can lead ...
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Journal ArticleNeurosurgery · July 2008
OBJECTIVE: Incisional cerebrospinal fluid (CSF) leak remains a significant cause of morbidity, particularly after posterior fossa surgery, with ranges between 4 and 17% in most series. We aimed to determine whether the use of a new polyethylene glycol (PEG ...
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Journal ArticleJ Neurosurg · December 2007
OBJECT: The authors of previous studies have shown that admission hyperglycemia or perioperative hyperglycemic events may predispose a patient to poor outcome after aneurysmal subarachnoid hemorrhage (SAH). The results of experimental evidence have suggest ...
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Journal ArticleNeurosurgery · December 2007
OBJECTIVE: The use of intraluminal shunting during carotid endarterectomy (CEA) remains controversial. Over the years, different shunting strategies have been used. More recently, the use of intraoperative electroencephalography and somatosensory evoked po ...
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Journal ArticleAJNR Am J Neuroradiol · September 2007
Treatment of sacral insufficiency fractures (SIFs) has traditionally been conservative, but several patients have been treated with percutaneous sacroplasty. Unfortunately, in the setting of severe, bilateral SIFs, cement may not withstand shear forces pre ...
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Journal ArticleNeurosurgery · April 2007
OBJECTIVE: To detail a potential complication of the use of vascularized pericranial flaps in the repair of dural defects, namely, flap hypertrophy secondary to venous engorgement. CLINICAL PRESENTATION: A 23-year-old man with a left parietal lobe hemangio ...
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Journal ArticleJ Agric Food Chem · June 28, 2006
Despite the prevalence of chloroacetamides as herbicides, little is known about the rates or products of acid- or base-catalyzed hydrolysis of these compounds. Mechanisms of acid-catalyzed reactions may parallel those catalyzed by (hydr)oxide minerals, whi ...
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Journal ArticleEpilepsia · April 2005
PURPOSE: Although the ketogenic diet has been in use for >80 years, little agreement exists as to which patients are most likely to have dramatic, sudden, and complete seizure control. METHODS: A case-control study was performed of children with intractabl ...
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