Scholars@Duke
Nishad Jayasundara

Nishad Jayasundara

Juli Plant Grainger Assistant Professor of Global Environmental Health
Environmental Sciences and Policy
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Selected Publications

An epigenetic memory at the CYP1A gene in cancer-resistant, pollution-adapted killifish.

Journal Article bioRxiv · August 16, 2024 Human exposure to polycyclic aromatic hydrocarbons (PAH) is a significant and growing public health problem. Frequent, high dose exposures are likely to increase due to a warming climate and increased frequency of large-scale wildfires. Here, we characteri ... Full text Link to item Cite

Environmental fluoride exposure and implications on potential pediatric kidney health risks: an approach with urinary biomarkers.

Journal Article Pediatric nephrology (Berlin, Germany) · May 2024 BackgroundEnvironmental fluoride exposure at elevated levels is potentially linked to kidney injury, and may contribute to chronic kidney disease of uncertain etiology (CKDu) as a risk factor. However, this link remains unclear, and examining the ... Full text Cite

Fluoride exposure and pediatric kidney health in dry, wet and intermediate climatic zone communities in Sri Lanka: Implications from urinary Cystatin-C, and albumin-creatinine ratio.

Journal Article Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) · March 2024 BackgroundHigh fluoride exposure is increasingly discussed attributing to kidney injury as a causative factor. Depending on geochemistry, differential fluoride levels in drinking water are identified in different regions in Sri Lanka. However, the ... Full text Cite

Transcriptomic and behavioral analyses reveal unique target tissues and molecular pathways associated with embryonic exposure to low level glyphosate and metal mixtures in zebrafish.

Journal Article The Science of the total environment · February 2024 Investigation of developmental molecular events following exposure to environmentally relevant agrochemical mixtures is critical to predicting their potential long-term ecological and human health risks. Here, we sought to uncover transcriptomic changes du ... Full text Cite

Body mass index and implications for pediatric kidney health: a cross-sectional study with urinary biomarkers.

Journal Article Pediatric nephrology (Berlin, Germany) · January 2024 BackgroundExtremes of unhealthy body weight, particularly obesity, are known to increase the risk of chronic kidney diseases. However, the current knowledge of kidney health outcomes associated with unhealthy body weight remains incomprehensive, e ... Full text Cite

Exploring the Utility of Urinary Creatinine Adjustment for KIM-1, NGAL, and Cystatin C for the Assessment of Kidney Function: Insights from the C-KidnEES Cohort.

Journal Article Children (Basel, Switzerland) · December 2023 Normalization of urinary biomarkers of kidney injury is a common practice in clinical and research settings to account for variations in urine concentration, and urinary creatinine is often used as a reference. However, to date, there is no consensus on th ... Full text Cite

Glyphosate and Fluoride in High-Hardness Drinking Water Are Positively Associated with Chronic Kidney Disease of Unknown Etiology (CKDu) in Sri Lanka

Journal Article Environmental Science and Technology Letters · October 10, 2023 Chronic kidney disease of uncertain etiology (CKDu) has emerged as a serious public health concern in farming communities globally, especially in Sri Lanka with 5%-20% of the adult population affected by the disease in CKDu-endemic regions. It is hypothesi ... Full text Cite

Mitochondrial dysfunction and oxidative stress contribute to cross-generational toxicity of benzo(a)pyrene in Danio rerio.

Journal Article Aquatic toxicology (Amsterdam, Netherlands) · October 2023 The potential for polycyclic aromatic hydrocarbons (PAHs) to have adverse effects that persist across generations is an emerging concern for human and wildlife health. This study evaluated the role of mitochondria, which are maternally inherited, in the cr ... Full text Open Access Cite

Bioenergetic Effects of Polycyclic Aromatic Hydrocarbon Resistance Manifest Later in Life in Offspring of Fundulus heteroclitus from the Elizabeth River.

Journal Article Environmental science & technology · October 2023 Shifts in key physiological processes can confer resistance to chemical pollutants. However, these adaptations may come with certain trade-offs, such as altered energy metabolic processes, as evident in Atlantic killifish (Fundulus heteroclitus) in ... Full text Cite

River zebrafish combine behavioral plasticity and generalized morphology with specialized sensory and metabolic physiology to survive in a challenging environment.

Journal Article Scientific reports · September 2023 Phenotypes that allow animals to detect, weather, and predict changes efficiently are essential for survival in fluctuating environments. Some phenotypes may remain specialized to suit an environment perfectly, while others become more plastic or generaliz ... Full text Cite

Performance evaluation of InfectID-BSI: A rapid quantitative PCR assay for detecting sepsis-associated organisms directly from whole blood.

Journal Article Journal of microbiological methods · August 2023 BackgroundBloodstream infections (BSIs) (presence of pathogenic organism in blood) that progress to sepsis (life-threatening organ dysfunction caused by the body's dysregulated response to an infection) is a major healthcare issue globally with cl ... Full text Cite

Environmental heat exposure and implications on renal health of pediatric communities in the dry climatic zone of Sri Lanka: An approach with urinary biomarkers.

Journal Article Environmental research · April 2023 Prolonged heat exposure during outdoor physical exertion can result in adverse renal health outcomes, and it is also supposed to be a driver of chronic kidney disease of uncertain etiology (CKDu) in tropical regions. School students are more likely to expe ... Full text Cite

The urinary proteome infers dysregulation of mitochondrial, lysosomal, and protein reabsorption processes in chronic kidney disease of unknown etiology (CKDu).

Journal Article Am J Physiol Renal Physiol · April 1, 2023 Chronic kidney disease (CKD) of uncertain etiology (CKDu) is a global health concern affecting tropical farming communities. CKDu is not associated with typical risk factors (e.g., diabetes) and strongly correlates with environmental drivers. To gain poten ... Full text Link to item Cite

Prevalence of Chronic Kidney Disease of Uncertain Etiology Within Selected Farming Communities in Rural Sri Lanka.

Journal Article Canadian journal of kidney health and disease · January 2023 BackgroundChronic kidney disease of uncertain etiology (CKDu) is an emergent health concern, particularly in tropical farming communities in several global hotspots, including Sri Lanka. This particular nephropathy is characterized by a progressiv ... Full text Cite

Thermal physiology integrated species distribution model predicts profound habitat fragmentation for estuarine fish with ocean warming.

Journal Article Scientific reports · December 2022 Species distribution models predict a poleward migration for marine ectotherms with ocean warming. However, a key limitation in current species distribution models (SDM) is that they do not account for population-specific heterogeneity in physiological res ... Full text Cite

A growing crisis for One Health: Impacts of plastic pollution across layers of biological function

Journal Article Frontiers in Marine Science · November 2, 2022 The global accumulation of plastic waste has reached crisis levels. The diverse and multilayered impacts of plastic on biological health prompts an evaluation of these effects from a One Health perspective, through which the complexity of these processes c ... Full text Cite

An epigenetic memory at the CYP1A gene in cancer-resistant, pollution-adapted killifish.

Journal Article bioRxiv · August 16, 2024 Human exposure to polycyclic aromatic hydrocarbons (PAH) is a significant and growing public health problem. Frequent, high dose exposures are likely to increase due to a warming climate and increased frequency of large-scale wildfires. Here, we characteri ... Full text Link to item Cite

Environmental fluoride exposure and implications on potential pediatric kidney health risks: an approach with urinary biomarkers.

Journal Article Pediatric nephrology (Berlin, Germany) · May 2024 BackgroundEnvironmental fluoride exposure at elevated levels is potentially linked to kidney injury, and may contribute to chronic kidney disease of uncertain etiology (CKDu) as a risk factor. However, this link remains unclear, and examining the ... Full text Cite

Fluoride exposure and pediatric kidney health in dry, wet and intermediate climatic zone communities in Sri Lanka: Implications from urinary Cystatin-C, and albumin-creatinine ratio.

Journal Article Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) · March 2024 BackgroundHigh fluoride exposure is increasingly discussed attributing to kidney injury as a causative factor. Depending on geochemistry, differential fluoride levels in drinking water are identified in different regions in Sri Lanka. However, the ... Full text Cite

Transcriptomic and behavioral analyses reveal unique target tissues and molecular pathways associated with embryonic exposure to low level glyphosate and metal mixtures in zebrafish.

Journal Article The Science of the total environment · February 2024 Investigation of developmental molecular events following exposure to environmentally relevant agrochemical mixtures is critical to predicting their potential long-term ecological and human health risks. Here, we sought to uncover transcriptomic changes du ... Full text Cite

Body mass index and implications for pediatric kidney health: a cross-sectional study with urinary biomarkers.

Journal Article Pediatric nephrology (Berlin, Germany) · January 2024 BackgroundExtremes of unhealthy body weight, particularly obesity, are known to increase the risk of chronic kidney diseases. However, the current knowledge of kidney health outcomes associated with unhealthy body weight remains incomprehensive, e ... Full text Cite

Exploring the Utility of Urinary Creatinine Adjustment for KIM-1, NGAL, and Cystatin C for the Assessment of Kidney Function: Insights from the C-KidnEES Cohort.

Journal Article Children (Basel, Switzerland) · December 2023 Normalization of urinary biomarkers of kidney injury is a common practice in clinical and research settings to account for variations in urine concentration, and urinary creatinine is often used as a reference. However, to date, there is no consensus on th ... Full text Cite

Glyphosate and Fluoride in High-Hardness Drinking Water Are Positively Associated with Chronic Kidney Disease of Unknown Etiology (CKDu) in Sri Lanka

Journal Article Environmental Science and Technology Letters · October 10, 2023 Chronic kidney disease of uncertain etiology (CKDu) has emerged as a serious public health concern in farming communities globally, especially in Sri Lanka with 5%-20% of the adult population affected by the disease in CKDu-endemic regions. It is hypothesi ... Full text Cite

Mitochondrial dysfunction and oxidative stress contribute to cross-generational toxicity of benzo(a)pyrene in Danio rerio.

Journal Article Aquatic toxicology (Amsterdam, Netherlands) · October 2023 The potential for polycyclic aromatic hydrocarbons (PAHs) to have adverse effects that persist across generations is an emerging concern for human and wildlife health. This study evaluated the role of mitochondria, which are maternally inherited, in the cr ... Full text Open Access Cite

Bioenergetic Effects of Polycyclic Aromatic Hydrocarbon Resistance Manifest Later in Life in Offspring of Fundulus heteroclitus from the Elizabeth River.

Journal Article Environmental science & technology · October 2023 Shifts in key physiological processes can confer resistance to chemical pollutants. However, these adaptations may come with certain trade-offs, such as altered energy metabolic processes, as evident in Atlantic killifish (Fundulus heteroclitus) in ... Full text Cite

River zebrafish combine behavioral plasticity and generalized morphology with specialized sensory and metabolic physiology to survive in a challenging environment.

Journal Article Scientific reports · September 2023 Phenotypes that allow animals to detect, weather, and predict changes efficiently are essential for survival in fluctuating environments. Some phenotypes may remain specialized to suit an environment perfectly, while others become more plastic or generaliz ... Full text Cite

Performance evaluation of InfectID-BSI: A rapid quantitative PCR assay for detecting sepsis-associated organisms directly from whole blood.

Journal Article Journal of microbiological methods · August 2023 BackgroundBloodstream infections (BSIs) (presence of pathogenic organism in blood) that progress to sepsis (life-threatening organ dysfunction caused by the body's dysregulated response to an infection) is a major healthcare issue globally with cl ... Full text Cite

Environmental heat exposure and implications on renal health of pediatric communities in the dry climatic zone of Sri Lanka: An approach with urinary biomarkers.

Journal Article Environmental research · April 2023 Prolonged heat exposure during outdoor physical exertion can result in adverse renal health outcomes, and it is also supposed to be a driver of chronic kidney disease of uncertain etiology (CKDu) in tropical regions. School students are more likely to expe ... Full text Cite

The urinary proteome infers dysregulation of mitochondrial, lysosomal, and protein reabsorption processes in chronic kidney disease of unknown etiology (CKDu).

Journal Article Am J Physiol Renal Physiol · April 1, 2023 Chronic kidney disease (CKD) of uncertain etiology (CKDu) is a global health concern affecting tropical farming communities. CKDu is not associated with typical risk factors (e.g., diabetes) and strongly correlates with environmental drivers. To gain poten ... Full text Link to item Cite

Prevalence of Chronic Kidney Disease of Uncertain Etiology Within Selected Farming Communities in Rural Sri Lanka.

Journal Article Canadian journal of kidney health and disease · January 2023 BackgroundChronic kidney disease of uncertain etiology (CKDu) is an emergent health concern, particularly in tropical farming communities in several global hotspots, including Sri Lanka. This particular nephropathy is characterized by a progressiv ... Full text Cite

Thermal physiology integrated species distribution model predicts profound habitat fragmentation for estuarine fish with ocean warming.

Journal Article Scientific reports · December 2022 Species distribution models predict a poleward migration for marine ectotherms with ocean warming. However, a key limitation in current species distribution models (SDM) is that they do not account for population-specific heterogeneity in physiological res ... Full text Cite

A growing crisis for One Health: Impacts of plastic pollution across layers of biological function

Journal Article Frontiers in Marine Science · November 2, 2022 The global accumulation of plastic waste has reached crisis levels. The diverse and multilayered impacts of plastic on biological health prompts an evaluation of these effects from a One Health perspective, through which the complexity of these processes c ... Full text Cite

A transdisciplinary approach to reducing global plastic pollution

Journal Article Frontiers in Marine Science · October 28, 2022 Full text Cite

Occupational heat exposure alone does not explain chronic kidney disease of uncertain aetiology (CKDu) in Sri Lanka

Journal Article Journal of Climate Change and Health · October 1, 2022 Aim: Chronic kidney disease of uncertain aetiology (CKDu) is an emerging health concern in tropical farming communities. The role of occupational heat exposure as a potential driver of CKDu remains debated. Our study examines occupational heat exposure and ... Full text Cite

Nanoplastics in Aquatic Environments: Impacts on Aquatic Species and Interactions with Environmental Factors and Pollutants.

Journal Article Toxics · June 2022 Plastic production began in the early 1900s and it has transformed our way of life. Despite the many advantages of plastics, a massive amount of plastic waste is generated each year, threatening the environment and human health. Because of their pervasiven ... Full text Cite

A review of molecular mechanisms linked to potential renal injury agents in tropical rural farming communities.

Journal Article Environmental toxicology and pharmacology · May 2022 The chronic kidney disease of unknown etiology (CKDu) is a global health concern primarily impacting tropical farming communities. Although the precise etiology is debated, CKDu is associated with environmental exposures including heat stress and chemical ... Full text Cite

Urinary biomarkers indicate pediatric renal injury among rural farming communities in Sri Lanka.

Journal Article Scientific reports · May 2022 Pediatric renal injury is an emerging health concern in communities affected by chronic kidney disease of uncertain etiology (CKDu). Early detection of susceptibilities through highly sensitive and specific biomarkers can lead to effective therapeutic and ... Full text Cite

Applicability of Novel Urinary Biomarkers for the Assessment of Renal Injury in Selected Occupational Groups in Sri Lanka: A Comparative Study with Conventional Markers.

Journal Article International journal of environmental research and public health · April 2022 Screening approaches with more robust biomarkers, are of the utmost importance in the characterization of renal injuries, particularly among communities with high burdens of chronic kidney disease of uncertain etiology (CKDu). The present study aimed to as ... Full text Cite

Urinary cystatin C: pediatric reference intervals and comparative assessment as a biomarker of renal injury among children in the regions with high burden of CKDu in Sri Lanka.

Journal Article World journal of pediatrics : WJP · March 2022 BackgroundCystatin C (Cys-C) is an emerging biomarker of renal diseases and its clinical use, particularly for screening the communities affected by chronic kidney disease of unknown etiology (CKDu), is hindered due to the lack of reference interv ... Full text Cite

Physiological and Molecular Responses in the Gill of the Swimming Crab Portunus trituberculatus During Long-Term Ammonia Stress

Journal Article Frontiers in Marine Science · December 9, 2021 Ammonia is a common environmental stressor encountered during aquaculture, and is a significant concern due to its adverse biological effects on vertebrate and invertebrate including crustaceans. However, little information is available on physiological an ... Full text Cite

Integrated physiological, transcriptome and metabolome analyses of the hepatopancreas of the female swimming crab Portunus trituberculatus under ammonia exposure.

Journal Article Ecotoxicology and environmental safety · November 2021 Ammonia is a common environmental pollutant in aquatic ecosystem and is also a significant concern in closed aquaculture systems. The threat of ammonia has been increasing with rising anthropogenic activities including intensified aquaculture. In this stud ... Full text Cite

Urinary Biomarkers of Renal Injury KIM-1 and NGAL: Reference Intervals for Healthy Pediatric Population in Sri Lanka.

Journal Article Children (Basel, Switzerland) · August 2021 Emerging renal biomarkers (e.g., kidney injury molecule-1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL)) are thought to be highly sensitive in diagnosing renal injury. However, global data on reference intervals for emerging biomarkers in y ... Full text Cite

Defining drinking water metal contaminant mixture risk by coupling zebrafish behavioral analysis with citizen science.

Journal Article Scientific reports · August 2021 Contaminated drinking water is an important public health consideration in New England where well water is often found to contain arsenic and other metals such as cadmium, lead, and uranium. Chronic or high level exposure to these metals have been associat ... Full text Cite

The role of gut microbial community and metabolomic shifts in adaptive resistance of Atlantic killifish (Fundulus heteroclitus) to polycyclic aromatic hydrocarbons.

Journal Article The Science of the total environment · July 2021 Featured Publication Altered gut microbiomes may play a role in rapid evolution to anthropogenic change but remain poorly understood. Atlantic killifish (Fundulus heteroclitus) in the Elizabeth River, VA have evolved resistance to polycyclic aromatic hydrocarbons (PAHs) and pr ... Full text Cite

Occupational Paraquat and Glyphosate Exposure May Decline Renal Functions among Rural Farming Communities in Sri Lanka.

Journal Article International journal of environmental research and public health · March 2021 Featured Publication Extensive use of herbicides is common among rural agricultural workers in Sri Lanka. Recent studies have postulated their role in the development of chronic kidney disease of unknown etiology (CKDu). Paraquat and glyphosate are leading herbicides used by s ... Full text Cite

Glucocorticoid-Responsive Transcription Factor Krüppel-Like Factor 9 Regulates fkbp5 and Metabolism.

Journal Article Frontiers in cell and developmental biology · January 2021 Krüppel-like factor 9 (Klf9) is a feedforward regulator of glucocorticoid receptor (GR) signaling. Here we show that in zebrafish klf9 is expressed with GR-dependent oscillatory dynamics in synchrony with fkbp5, a GR target that encodes a neg ... Full text Cite

A polycyclic aromatic hydrocarbon-enriched environmental chemical mixture enhances AhR, antiapoptotic signaling and a proliferative phenotype in breast cancer cells.

Journal Article Carcinogenesis · December 31, 2020 Featured Publication Emerging evidence suggests the role of environmental chemicals, in particular endocrine-disrupting chemicals (EDCs), in progression of breast cancer and treatment resistance, which can impact survival outcomes. However, most research tends to focus on tumo ... Full text Link to item Cite

The Utility of Novel Renal Biomarkers in Assessment of Chronic Kidney Disease of Unknown Etiology (CKDu): A Review.

Journal Article International journal of environmental research and public health · December 2020 Chronic Kidney Disease (CKD) is a globally prevalent non-communicable disease with significant mortality and morbidity. It is typically associated with diabetes and hypertension; however, over the last two decades, an emergence of CKD of unknown etiology ( ... Full text Cite

Kidney developmental effects of metal-herbicide mixtures: Implications for chronic kidney disease of unknown etiology.

Journal Article Environment international · November 2020 Chronic kidney disease of unknown etiology (CKDu) is an emerging global concern affecting several agricultural communities in the Americas and South Asia. Environmental contaminants such as heavy metals (e.g., Cd, As, Pb, and V) and organic pesticides (e.g ... Full text Cite

Mitochondrial response and resilience to anthropogenic chemicals during embryonic development.

Journal Article Comparative biochemistry and physiology. Toxicology & pharmacology : CBP · July 2020 Featured Publication Mitochondria are integral to maintaining cellular homeostasis. Optimum mitochondrial function is critical during embryonic development, as they play a key role in early signaling cascades and epigenetic programming, in addition to sustaining an adequate en ... Full text Cite

Embryonic Fundulus heteroclitus responses to sediment extracts from differentially contaminated sites in the Elizabeth River, VA.

Journal Article Ecotoxicology (London, England) · November 2019 Sites along the Elizabeth River are contaminated with polycyclic aromatic hydrocarbons (PAHs) from historical creosote production and other industrial processes. Previous studies have demonstrated that Atlantic killifish collected from sites throughout the ... Full text Cite

Outcomes of developmental exposure to total particulate matter from cigarette smoke in zebrafish (Danio rerio).

Journal Article Neurotoxicology · September 2018 The effects of prenatal exposure to cigarette smoke remain a subject of major interest, especially as it relates to neural development and adverse behavioral outcomes. Several studies have investigated the developmental toxicity of cigarette smoke componen ... Full text Link to item Cite

Uptake, tissue distribution, and toxicity of polystyrene nanoparticles in developing zebrafish (Danio rerio).

Journal Article Aquat Toxicol · January 2018 Plastic pollution is a critical environmental concern and comprises the majority of anthropogenic debris in the ocean, including macro, micro, and likely nanoscale (less than 100nm in at least one dimension) plastic particles. While the toxicity of macropl ... Full text Link to item Cite

Assessing Cancer Risk Associated with Aquatic Polycyclic Aromatic Hydrocarbon Pollution Reveals Dietary Routes of Exposure and Vulnerable Populations.

Journal Article J Environ Public Health · 2018 Polycyclic aromatic hydrocarbon (PAH) exposure is widespread, and many PAHs are considered carcinogenic. The PAH-contaminated AWI Superfund site in Virginia provides a model for studying a complex PAH mixture and its extrapolation to cancer risk and PAH ex ... Full text Link to item Cite

Ecological significance of mitochondrial toxicants.

Journal Article Toxicology · November 2017 Mitochondrial dysfunction with exposure to anthropogenic contaminants is a critical concern in biomedical and ecological health. Importantly, understanding the role of mitotoxicants in modulating organismal fitness and survival, particularly in the context ... Full text Cite

Cost of Tolerance: Physiological Consequences of Evolved Resistance to Inhabit a Polluted Environment in Teleost Fish Fundulus heteroclitus.

Journal Article Environmental science & technology · August 2017 Anthropogenic stressors, including pollutants, are key evolutionary drivers. It is hypothesized that rapid evolution to anthropogenic changes may alter fundamental physiological processes (e.g., energy metabolism), compromising an organism's capacity to re ... Full text Cite

Resistance to polycyclic aromatic hydrocarbon toxicity and associated bioenergetic consequences in a population of Fundulus heteroclitus.

Journal Article Ecotoxicology (London, England) · April 2017 Several locations in the Elizabeth River, VA, USA are highly contaminated with polycyclic aromatic hydrocarbons (PAHs) due to the release of creosote mixtures from wood treatment facilities. Interestingly, some populations of Atlantic killifish (Fundulus h ... Full text Cite

A bioenergetics assay for studying the effects of environmental stressors on mitochondrial function in vivo in zebrafish larvae.

Journal Article Comparative biochemistry and physiology. Toxicology & pharmacology : CBP · February 2017 Mitochondria, an integral component of cellular energy metabolism and other key functions, are extremely vulnerable to damage by environmental stressors. Although methods to measure mitochondrial function in vitro exist, sensitive, medium- to high-throughp ... Full text Cite

Application of ecosystem services in natural resource management decision making.

Journal Article Integrated environmental assessment and management · January 2017 An ecosystem services (ES) approach to natural resource management (NRM) can provide the framework for balancing economic, ecological, and societal drivers in decision making. The efficacy of such an approach depends on the successful execution of several ... Full text Cite

Assessing niche width of endothermic fish from genes to ecosystem.

Journal Article Proceedings of the National Academy of Sciences of the United States of America · July 2015 Endothermy in vertebrates has been postulated to confer physiological and ecological advantages. In endothermic fish, niche expansion into cooler waters is correlated with specific physiological traits and is hypothesized to lead to greater foraging succes ... Full text Cite

Antarctic notothenioid fish: what are the future consequences of 'losses' and 'gains' acquired during long-term evolution at cold and stable temperatures?

Journal Article The Journal of experimental biology · June 2015 Antarctic notothenioids dominate the fish fauna of the Southern Ocean. Evolution for millions of years at cold and stable temperatures has led to the acquisition of numerous biochemical traits that allow these fishes to thrive in sub-zero waters. The gain ... Full text Cite

Proteomic analysis of cardiac response to thermal acclimation in the eurythermal goby fish Gillichthys mirabilis.

Journal Article The Journal of experimental biology · May 2015 Cardiac function is thought to play a central role in determining thermal optima and tolerance limits in teleost fishes. Investigating proteomic responses to temperature in cardiac tissues may provide insights into mechanisms supporting the thermal plastic ... Full text Cite

AHR2-Mediated transcriptomic responses underlying the synergistic cardiac developmental toxicity of PAHs.

Journal Article Toxicological sciences : an official journal of the Society of Toxicology · February 2015 Polycyclic aromatic hydrocarbons (PAHs) induce developmental defects including cardiac deformities in fish. The aryl hydrocarbon receptor (AHR) mediates the toxicity of some PAHs. Exposure to a simple PAH mixture during embryo development consisting of an ... Full text Cite

High-Throughput Tissue Bioenergetics Analysis Reveals Identical Metabolic Allometric Scaling for Teleost Hearts and Whole Organisms.

Journal Article PloS one · January 2015 Organismal metabolic rate, a fundamental metric in biology, demonstrates an allometric scaling relationship with body size. Fractal-like vascular distribution networks of biological systems are proposed to underlie metabolic rate allometric scaling laws fr ... Full text Cite

Teratogenic, bioenergetic, and behavioral effects of exposure to total particulate matter on early development of zebrafish (Danio rerio) are not mimicked by nicotine.

Journal Article Neurotoxicol Teratol · 2015 Cigarette smoke has been associated with a number of pathologies; however, the mechanisms leading to developmental effects are yet to be fully understood. The zebrafish embryo is regarded as a 'bridge model'; however, not many studies examined its applicab ... Full text Link to item Cite

Effects of temperature acclimation on Pacific bluefin tuna (Thunnus orientalis) cardiac transcriptome.

Journal Article American journal of physiology. Regulatory, integrative and comparative physiology · November 2013 Little is known about the mechanisms underpinning thermal plasticity of vertebrate hearts. Bluefin tuna hearts offer a unique model to investigate processes underlying thermal acclimation. Their hearts, while supporting an endothermic physiology, operate a ... Full text Cite

Effects of temperature acclimation on cardiorespiratory performance of the Antarctic notothenioid Trematomus bernacchii

Journal Article Polar Biology · July 1, 2013 Notothenioid fishes of the Southern Ocean have evolved under cold and stable temperatures for millions of years. Due to rising temperatures in the Southern Ocean, investigating thermal limits and the capacities for inducing a temperature acclimation respon ... Full text Cite

Physiological plasticity of cardiorespiratory function in a eurythermal marine teleost, the longjaw mudsucker, Gillichthys mirabilis.

Journal Article The Journal of experimental biology · June 2013 An insufficient supply of oxygen under thermal stress is thought to define thermal optima and tolerance limits in teleost fish. When under thermal stress, cardiac function plays a crucial role in sustaining adequate oxygen supply for respiring tissues. Thu ... Full text Cite

Microarray gene expression profiles from mature gonad tissues of Atlantic bluefin tuna, Thunnus thynnus in the Gulf of Mexico.

Journal Article BMC genomics · October 2012 BackgroundBluefin tunas are highly prized pelagic fish species representing a significant economic resource to fisheries throughout the world. Atlantic bluefin tuna (Thunnus thynnus) populations have significantly declined due to overexploitation. ... Full text Cite

Cardiac thermal plasticity in the longjaw mudsucker Gillichthys mirabilis

Conference INTEGRATIVE AND COMPARATIVE BIOLOGY · 2012 Cite

Anti-lipopolysaccharide factors in the American lobster Homarus americanus: molecular characterization and transcriptional response to Vibrio fluvialis challenge.

Journal Article Comparative biochemistry and physiology. Part D, Genomics & proteomics · December 2008 Two partial mRNA sequences predicted to encode anti-lipopolysaccharide factors (ALFs) were identified among expressed sequence tags generated from the American lobster Homarus americanus and complete cDNA sequences were obtained from library clones. Compar ... Full text Cite

Gill-specific transcriptional regulation of Na+/K+ -ATPase alpha-subunit in the euryhaline shore crab Pachygrapsus marmoratus: sequence variants and promoter structure.

Journal Article The Journal of experimental biology · June 2007 The sodium pump (Na+/K+ -ATPase) has been implicated in osmoregulatory ion transport in many aquatic animals. In the euryhaline hyper-hypoosmoregulating shore crab Pachygrapsus marmoratus, induction of Na+/K+ -ATPase alpha-subunit mRNA varies between gills ... Full text Cite