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Adrian Christopher Angold

Associate Professor Emeritus of Psychiatry and Behavioral Sciences
Psychiatry, Child & Family Mental Health & Community Psychiatry
Box 3454 Med Ctr, Durham, NC 27710
Brightleaf SQ Ste 22B, 905 W Main St, Durham, NC 27701

Selected Publications


Early Pubertal Timing and Testosterone Associated With Higher Levels of Adolescent Depression in Girls.

Journal Article J Am Acad Child Adolesc Psychiatry · December 2019 OBJECTIVE: The prevalence of depression increases dramatically during puberty in girls. Earlier work in this sample reported that the sex steroids estradiol and testosterone were associated with increased depression in girls. Using three additional data wa ... Full text Link to item Cite

Use, Persistence, and Intensity: Patterns of Care for Children’s Mental Health Across One Year

Chapter · January 1, 2017 This paper explores the use, persistence, and intensity of services for children’s mental health problems across a variety of service sectors during a one year period. Data come from the Great Smoky Mountains Study. Analyses focus on children’s psychiatric ... Full text Cite

The Great Smoky Mountains Study: developmental epidemiology in the southeastern United States.

Journal Article Soc Psychiatry Psychiatr Epidemiol · May 2016 AIMS: To describe the Great Smoky Mountains Study (GSMS). METHODS: GSMS is a longitudinal study of child psychiatric disorders that began in 1992 to look at need for mental health services in a rural area of the USA. Over 20 years it has expanded its range ... Full text Link to item Cite

Developmental Epidemiology

Chapter · September 8, 2015 This chapter discusses developmental psychopathology from the viewpoint of epidemiology, "the study of health and illness in human populations". After a brief introduction to some of the basic concepts of the epidemiological method, it discusses what moder ... Full text Cite

Psychological and Psychosocial Impairment in Preschoolers With Selective Eating.

Journal Article Pediatrics · September 2015 OBJECTIVE: We examined the clinical significance of moderate and severe selective eating (SE). Two levels of SE were examined in relation to concurrent psychiatric symptoms and as a risk factor for the emergence of later psychiatric symptoms. Findings are ... Full text Link to item Cite

Genome-Wide Meta-Analysis of Longitudinal Alcohol Consumption Across Youth and Early Adulthood.

Journal Article Twin Res Hum Genet · August 2015 The public health burden of alcohol is unevenly distributed across the life course, with levels of use, abuse, and dependence increasing across adolescence and peaking in early adulthood. Here, we leverage this temporal patterning to search for common gene ... Full text Link to item Cite

Increase in untreated cases of psychiatric disorders during the transition to adulthood.

Journal Article Psychiatr Serv · April 1, 2015 OBJECTIVE: During the transition to adulthood, youths face challenges that may limit their likelihood of obtaining services for psychiatric problems. The goal of this analysis was to estimate changes in rates of service use and untreated psychiatric disord ... Full text Link to item Cite

Preschool anxiety disorders predict different patterns of amygdala-prefrontal connectivity at school-age.

Journal Article PLoS One · 2015 OBJECTIVE: In this prospective, longitudinal study of young children, we examined whether a history of preschool generalized anxiety, separation anxiety, and/or social phobia is associated with amygdala-prefrontal dysregulation at school-age. As an explora ... Full text Open Access Link to item Cite

Are children and adolescents with food allergies at increased risk for psychopathology?

Journal Article J Psychosom Res · December 2014 OBJECTIVE: Living with food allergy is a unique and potentially life-threatening stressor that requires constant vigilance to food-related stimuli, but little is known about whether adolescents with food allergies are at increased risk for psychopathology- ... Full text Link to item Cite

Adult diagnostic and functional outcomes of DSM-5 disruptive mood dysregulation disorder.

Journal Article Am J Psychiatry · June 2014 OBJECTIVE: Disruptive mood dysregulation disorder (DMDD) is a new disorder for DSM-5 that is uncommon and frequently co-occurs with other psychiatric disorders. Here, the authors test whether meeting diagnostic criteria for this disorder in childhood predi ... Full text Link to item Cite

Sleep problems predict and are predicted by generalized anxiety/depression and oppositional defiant disorder.

Journal Article J Am Acad Child Adolesc Psychiatry · May 2014 OBJECTIVE: We tested whether sleep problems co-occur with, precede, and/or follow common psychiatric disorders during childhood and adolescence. We also clarified the role of comorbidity and tested for specificity of associations among sleep problems and p ... Full text Link to item Cite

Perceived family impact of preschool anxiety disorders.

Journal Article J Am Acad Child Adolesc Psychiatry · April 2014 OBJECTIVE: We examined the perceived impact of child anxiety disorders on family functioning, because such impact is a key predictor of mental health service receipt. In addition, we examined the relative impact of preschool anxiety compared to that of oth ... Full text Link to item Cite

Longitudinal patterns of anxiety from childhood to adulthood: the Great Smoky Mountains Study.

Journal Article J Am Acad Child Adolesc Psychiatry · January 2014 OBJECTIVE: The aims of this study were 2-fold: to provide a brief introduction to the prospective longitudinal Great Smoky Mountains Study and review recent findings; and to use this sample to conduct an epidemiologic analysis of common childhood anxiety d ... Full text Link to item Cite

Preschool anxiety disorders in pediatric primary care: prevalence and comorbidity.

Journal Article J Am Acad Child Adolesc Psychiatry · December 2013 OBJECTIVE: We sought to establish prevalence rates and detail patterns of comorbidity for generalized anxiety disorder, separation anxiety disorder, and social phobia in preschool-aged children. METHOD: The Duke Preschool Anxiety Study, a screen-stratified ... Full text Link to item Cite

C-reactive protein and substance use disorders in adolescence and early adulthood: a prospective analysis.

Journal Article Drug Alcohol Depend · December 1, 2013 BACKGROUND: Dysregulated immune function and elevated inflammation markers are seen in adults with chronic diseases, including some psychiatric disorders, but evidence on inflammation in the case of drug abuse is conflicting. OBJECTIVE: To test the concurr ... Full text Link to item Cite

Children with both asthma and depression are at risk for heightened inflammation.

Journal Article J Pediatr · November 2013 OBJECTIVE: To test whether children and adolescents with co-occurring asthma and depression are at risk for elevated inflammation-concurrently and at the next assessment. STUDY DESIGN: Up to 6 yearly assessments per person from the prospective, population- ... Full text Link to item Cite

Sex-differentiated changes in C-reactive protein from ages 9 to 21: the contributions of BMI and physical/sexual maturation.

Journal Article Psychoneuroendocrinology · October 2013 BACKGROUND: Sex differences in levels of C-reactive protein (CRP) are well established in adulthood, but little is known about when and why they emerge. Here, we tested longitudinal models of CRP levels from ages 9 to 21, when marked physical and behaviora ... Full text Link to item Cite

Impact of bullying in childhood on adult health, wealth, crime, and social outcomes.

Journal Article Psychol Sci · October 2013 Bullying is a serious problem for schools, parents, and public-policymakers alike. Bullying creates risks of health and social problems in childhood, but it is unclear if such risks extend into adulthood. A large cohort of children was assessed for bullyin ... Full text Link to item Cite

Irritable mood as a symptom of depression in youth: prevalence, developmental, and clinical correlates in the Great Smoky Mountains Study.

Journal Article J Am Acad Child Adolesc Psychiatry · August 2013 OBJECTIVE: DSM-IV grants episodic irritability an equal status to low mood as a cardinal criterion for the diagnosis of depression in youth, yet not in adults; however, evidence for irritability as a major criterion of depression in youth is lacking. This ... Full text Link to item Cite

Diagnostic transitions from childhood to adolescence to early adulthood.

Journal Article J Child Psychol Psychiatry · July 2013 BACKGROUND: Quantifying diagnostic transitions across development is needed to estimate the long-term burden of mental illness. This study estimated patterns of diagnostic transitions from childhood to adolescence and from adolescence to early adulthood. M ... Full text Link to item Cite

Early Pubertal Timing and Testosterone Associated With Higher Levels of Adolescent Depression in Girls.

Journal Article J Am Acad Child Adolesc Psychiatry · December 2019 OBJECTIVE: The prevalence of depression increases dramatically during puberty in girls. Earlier work in this sample reported that the sex steroids estradiol and testosterone were associated with increased depression in girls. Using three additional data wa ... Full text Link to item Cite

Use, Persistence, and Intensity: Patterns of Care for Children’s Mental Health Across One Year

Chapter · January 1, 2017 This paper explores the use, persistence, and intensity of services for children’s mental health problems across a variety of service sectors during a one year period. Data come from the Great Smoky Mountains Study. Analyses focus on children’s psychiatric ... Full text Cite

The Great Smoky Mountains Study: developmental epidemiology in the southeastern United States.

Journal Article Soc Psychiatry Psychiatr Epidemiol · May 2016 AIMS: To describe the Great Smoky Mountains Study (GSMS). METHODS: GSMS is a longitudinal study of child psychiatric disorders that began in 1992 to look at need for mental health services in a rural area of the USA. Over 20 years it has expanded its range ... Full text Link to item Cite

Developmental Epidemiology

Chapter · September 8, 2015 This chapter discusses developmental psychopathology from the viewpoint of epidemiology, "the study of health and illness in human populations". After a brief introduction to some of the basic concepts of the epidemiological method, it discusses what moder ... Full text Cite

Psychological and Psychosocial Impairment in Preschoolers With Selective Eating.

Journal Article Pediatrics · September 2015 OBJECTIVE: We examined the clinical significance of moderate and severe selective eating (SE). Two levels of SE were examined in relation to concurrent psychiatric symptoms and as a risk factor for the emergence of later psychiatric symptoms. Findings are ... Full text Link to item Cite

Genome-Wide Meta-Analysis of Longitudinal Alcohol Consumption Across Youth and Early Adulthood.

Journal Article Twin Res Hum Genet · August 2015 The public health burden of alcohol is unevenly distributed across the life course, with levels of use, abuse, and dependence increasing across adolescence and peaking in early adulthood. Here, we leverage this temporal patterning to search for common gene ... Full text Link to item Cite

Increase in untreated cases of psychiatric disorders during the transition to adulthood.

Journal Article Psychiatr Serv · April 1, 2015 OBJECTIVE: During the transition to adulthood, youths face challenges that may limit their likelihood of obtaining services for psychiatric problems. The goal of this analysis was to estimate changes in rates of service use and untreated psychiatric disord ... Full text Link to item Cite

Preschool anxiety disorders predict different patterns of amygdala-prefrontal connectivity at school-age.

Journal Article PLoS One · 2015 OBJECTIVE: In this prospective, longitudinal study of young children, we examined whether a history of preschool generalized anxiety, separation anxiety, and/or social phobia is associated with amygdala-prefrontal dysregulation at school-age. As an explora ... Full text Open Access Link to item Cite

Are children and adolescents with food allergies at increased risk for psychopathology?

Journal Article J Psychosom Res · December 2014 OBJECTIVE: Living with food allergy is a unique and potentially life-threatening stressor that requires constant vigilance to food-related stimuli, but little is known about whether adolescents with food allergies are at increased risk for psychopathology- ... Full text Link to item Cite

Adult diagnostic and functional outcomes of DSM-5 disruptive mood dysregulation disorder.

Journal Article Am J Psychiatry · June 2014 OBJECTIVE: Disruptive mood dysregulation disorder (DMDD) is a new disorder for DSM-5 that is uncommon and frequently co-occurs with other psychiatric disorders. Here, the authors test whether meeting diagnostic criteria for this disorder in childhood predi ... Full text Link to item Cite

Sleep problems predict and are predicted by generalized anxiety/depression and oppositional defiant disorder.

Journal Article J Am Acad Child Adolesc Psychiatry · May 2014 OBJECTIVE: We tested whether sleep problems co-occur with, precede, and/or follow common psychiatric disorders during childhood and adolescence. We also clarified the role of comorbidity and tested for specificity of associations among sleep problems and p ... Full text Link to item Cite

Perceived family impact of preschool anxiety disorders.

Journal Article J Am Acad Child Adolesc Psychiatry · April 2014 OBJECTIVE: We examined the perceived impact of child anxiety disorders on family functioning, because such impact is a key predictor of mental health service receipt. In addition, we examined the relative impact of preschool anxiety compared to that of oth ... Full text Link to item Cite

Longitudinal patterns of anxiety from childhood to adulthood: the Great Smoky Mountains Study.

Journal Article J Am Acad Child Adolesc Psychiatry · January 2014 OBJECTIVE: The aims of this study were 2-fold: to provide a brief introduction to the prospective longitudinal Great Smoky Mountains Study and review recent findings; and to use this sample to conduct an epidemiologic analysis of common childhood anxiety d ... Full text Link to item Cite

Preschool anxiety disorders in pediatric primary care: prevalence and comorbidity.

Journal Article J Am Acad Child Adolesc Psychiatry · December 2013 OBJECTIVE: We sought to establish prevalence rates and detail patterns of comorbidity for generalized anxiety disorder, separation anxiety disorder, and social phobia in preschool-aged children. METHOD: The Duke Preschool Anxiety Study, a screen-stratified ... Full text Link to item Cite

C-reactive protein and substance use disorders in adolescence and early adulthood: a prospective analysis.

Journal Article Drug Alcohol Depend · December 1, 2013 BACKGROUND: Dysregulated immune function and elevated inflammation markers are seen in adults with chronic diseases, including some psychiatric disorders, but evidence on inflammation in the case of drug abuse is conflicting. OBJECTIVE: To test the concurr ... Full text Link to item Cite

Children with both asthma and depression are at risk for heightened inflammation.

Journal Article J Pediatr · November 2013 OBJECTIVE: To test whether children and adolescents with co-occurring asthma and depression are at risk for elevated inflammation-concurrently and at the next assessment. STUDY DESIGN: Up to 6 yearly assessments per person from the prospective, population- ... Full text Link to item Cite

Sex-differentiated changes in C-reactive protein from ages 9 to 21: the contributions of BMI and physical/sexual maturation.

Journal Article Psychoneuroendocrinology · October 2013 BACKGROUND: Sex differences in levels of C-reactive protein (CRP) are well established in adulthood, but little is known about when and why they emerge. Here, we tested longitudinal models of CRP levels from ages 9 to 21, when marked physical and behaviora ... Full text Link to item Cite

Impact of bullying in childhood on adult health, wealth, crime, and social outcomes.

Journal Article Psychol Sci · October 2013 Bullying is a serious problem for schools, parents, and public-policymakers alike. Bullying creates risks of health and social problems in childhood, but it is unclear if such risks extend into adulthood. A large cohort of children was assessed for bullyin ... Full text Link to item Cite

Irritable mood as a symptom of depression in youth: prevalence, developmental, and clinical correlates in the Great Smoky Mountains Study.

Journal Article J Am Acad Child Adolesc Psychiatry · August 2013 OBJECTIVE: DSM-IV grants episodic irritability an equal status to low mood as a cardinal criterion for the diagnosis of depression in youth, yet not in adults; however, evidence for irritability as a major criterion of depression in youth is lacking. This ... Full text Link to item Cite

Diagnostic transitions from childhood to adolescence to early adulthood.

Journal Article J Child Psychol Psychiatry · July 2013 BACKGROUND: Quantifying diagnostic transitions across development is needed to estimate the long-term burden of mental illness. This study estimated patterns of diagnostic transitions from childhood to adolescence and from adolescence to early adulthood. M ... Full text Link to item Cite

Genes, environments, and developmental research: methods for a multi-site study of early substance abuse.

Journal Article Twin Res Hum Genet · April 2013 The importance of including developmental and environmental measures in genetic studies of human pathology is widely acknowledged, but few empirical studies have been published. Barriers include the need for longitudinal studies that cover relevant develop ... Full text Link to item Cite

Young Adult Obesity and Household Income: Effects of Unconditional Cash Transfers.

Journal Article Am Econ J Appl Econ · April 1, 2013 We investigate the effect of household cash transfers during childhood on young adult body mass indexes (BMI). The effects of extra income differ depending on the household's initial socioeconomic status (SES). Children from the initially poorest household ... Full text Link to item Cite

Adult psychiatric outcomes of bullying and being bullied by peers in childhood and adolescence.

Journal Article JAMA Psychiatry · April 2013 IMPORTANCE: Both bullies and victims of bullying are at risk for psychiatric problems in childhood, but it is unclear if this elevated risk extends into early adulthood. OBJECTIVE: To test whether bullying and/or being bullied in childhood predicts psychia ... Full text Link to item Cite

Prevalence, comorbidity, and correlates of DSM-5 proposed disruptive mood dysregulation disorder.

Journal Article Am J Psychiatry · February 2013 OBJECTIVE: No empirical studies on the DSM-5 proposed disruptive mood dysregulation disorder have yet been published. This study estimated prevalence, comorbidity, and correlates of this proposed disorder in the community. METHOD: Prevalence rates were est ... Full text Link to item Cite

Indirect comorbidity in childhood and adolescence.

Journal Article Front Psychiatry · 2013 OBJECTIVE: Comorbidity between psychiatric disorders is common, but pairwise associations between two disorders may be explained by the presence of other diagnoses that are associated with both disorders or "indirect" comorbidity. MATERIALS AND METHODS: Co ... Full text Link to item Cite

Generalized anxiety and C-reactive protein levels: a prospective, longitudinal analysis.

Journal Article Psychol Med · December 2012 BACKGROUND: Generalized anxiety disorder (GAD) is highly co-morbid with depression. Depression is associated with elevated levels of the inflammation marker C-reactive protein (CRP), cross-sectionally and over time. To date, no studies have looked at the a ... Full text Link to item Cite

About 7% of 4-year-olds in Norway meet criteria for a psychiatric diagnosis

Journal Article Evidence-Based Mental Health · November 1, 2012 Full text Cite

Predicting persistent alcohol problems: a prospective analysis from the Great Smoky Mountain Study.

Journal Article Psychol Med · September 2012 BACKGROUND: Rates of alcohol disorders peak in late adolescence and decrease substantially into the mid-20s. Our aim was to identify risk factors that predict alcohol problems that persist into the mid-20s. METHOD: Data are from the prospective, population ... Full text Link to item Cite

Prevalence of psychiatric disorders in preschoolers.

Journal Article J Child Psychol Psychiatry · June 2012 BACKGROUND:   Many disorders in childhood and adolescence were already present in the preschool years. However, there is little empirical research on the prevalence of psychiatric disorders in young children. A true community study using structured diagnos ... Full text Link to item Cite

Psychiatric diagnostic interviews for children and adolescents: a comparative study.

Journal Article J Am Acad Child Adolesc Psychiatry · May 2012 OBJECTIVE: To compare examples of three styles of psychiatric interviews for youth: the Diagnostic Interview Schedule for Children (DISC) ("respondent-based"), the Child and Adolescent Psychiatric Assessment (CAPA) ("interviewer-based"), and the Developmen ... Full text Link to item Cite

Cumulative depression episodes predict later C-reactive protein levels: a prospective analysis.

Journal Article Biol Psychiatry · January 1, 2012 BACKGROUND: Depression is associated with elevated levels of the inflammation marker C-reactive protein (CRP); yet, the direction of this association remains unclear. This study tested bi-directional longitudinal associations between CRP and depression in ... Full text Link to item Cite

Child-, adolescent- and young adult-onset depressions: differential risk factors in development?

Journal Article Psychol Med · November 2011 BACKGROUND: Previous research reported that childhood adversity predicts juvenile- onset but not adult-onset depression, but studies confounded potentially genuine differences in adversity with differences in the recency with which adversity was experience ... Full text Link to item Cite

Trends in psychopathology across the adolescent years: what changes when children become adolescents, and when adolescents become adults?

Journal Article J Child Psychol Psychiatry · October 2011 BACKGROUND: Little is known about changes in the prevalence of psychiatric disorders between childhood and adolescence, and adolescence and adulthood. METHODS: We reviewed papers reporting prevalence rates of psychiatric disorders separately for childhood, ... Full text Link to item Cite

The NIMH Child Emotional Faces Picture Set (NIMH-ChEFS): a new set of children's facial emotion stimuli.

Journal Article Int J Methods Psychiatr Res · September 2011 With the emergence of new technologies, there has been an explosion of basic and clinical research on the affective and cognitive neuroscience of face processing and emotion perception. Adult emotional face stimuli are commonly used in these studies. For d ... Full text Link to item Cite

Child μ-opioid receptor gene variant influences parent-child relations.

Journal Article Neuropsychopharmacology · May 2011 Variation in the μ-opioid receptor gene has been associated with early social behavior in mice and rhesus macaques. The current study tested whether the functional OPRM1 A118G predicted various indices of social relations in children. The sample included 2 ... Full text Link to item Cite

Distinct neural signatures of threat learning in adolescents and adults.

Journal Article Proc Natl Acad Sci U S A · March 15, 2011 Most teenage fears subside with age, a change that may reflect brain maturation in the service of refined fear learning. Whereas adults clearly demarcate safe situations from real dangers, attenuating fear to the former but not the latter, adolescents' imm ... Full text Link to item Cite

Cumulative prevalence of psychiatric disorders by young adulthood: a prospective cohort analysis from the Great Smoky Mountains Study.

Journal Article J Am Acad Child Adolesc Psychiatry · March 2011 OBJECTIVE: No longitudinal studies beginning in childhood have estimated the cumulative prevalence of psychiatric illness from childhood into young adulthood. The objective of this study was to estimate the cumulative prevalence of psychiatric disorders by ... Full text Link to item Cite

The developmental epidemiology of anxiety disorders: Phenomenology, prevalence, and comorbidity

Chapter · January 1, 2011 In this chapter we review the prevalence and comorbidity of anxiety disorders in general, and where possible the specifics of separation anxiety disorder (SAD), generalized anxiety disorder (GAD), specific phobias, panic, social phobia, and panic disorder. ... Full text Cite

Developmental pathways in oppositional defiant disorder and conduct disorder.

Journal Article J Abnorm Psychol · November 2010 The Diagnostic and Statistical Manual of Mental Disorders, 4th edition (DSM-IV; American Psychiatric Association, 1994) specifies a developmental relationship between oppositional defiant disorder (ODD) and conduct disorder (CD). Evidence for this link is ... Full text Link to item Cite

Psychiatric symptoms in bereaved versus nonbereaved youth and young adults: a longitudinal epidemiological study.

Journal Article J Am Acad Child Adolesc Psychiatry · November 2010 OBJECTIVE: To examine potential differences in psychiatric symptoms between parent-bereaved youth (N = 172), youth who experienced the death of another relative (N = 815), and nonbereaved youth (N = 235), aged 11 to 21 years, above and beyond antecedent en ... Full text Link to item Cite

Outcomes of early pubertal timing in young women: a prospective population-based study.

Journal Article Am J Psychiatry · October 2010 OBJECTIVE: Early pubertal timing in girls is associated with psychosocial problems throughout adolescence, but it is unclear whether these problems persist into young adulthood. The authors analyzed outcomes in adolescence and young adulthood in girls in a ... Full text Link to item Cite

Posttraumatic stress without trauma in children.

Journal Article Am J Psychiatry · September 2010 OBJECTIVE: It remains unclear to what degree children show signs of posttraumatic stress disorder (PTSD) after experiencing low-magnitude stressors, or stressors milder than those required for the DSM-IV extreme stressor criterion. METHOD: A representative ... Full text Link to item Cite

Longitudinal dimensionality of adolescent psychopathology: testing the differentiation hypothesis.

Journal Article J Child Psychol Psychiatry · August 2010 BACKGROUND: The differentiation hypothesis posits that the underlying liability distribution for psychopathology is of low dimensionality in young children, inflating diagnostic comorbidity rates, but increases in dimensionality with age as latent syndrome ... Full text Link to item Cite

Association of family income supplements in adolescence with development of psychiatric and substance use disorders in adulthood among an American Indian population.

Journal Article JAMA · May 19, 2010 CONTEXT: In a natural experiment in which some families received income supplements, prevalence of adolescent behavioral symptoms decreased significantly. These adolescents are now young adults. OBJECTIVE: To examine the effects of income supplements in ad ... Full text Link to item Cite

Specifying criminogenic strains: Stress dynamics and conduct disorder trajectories

Journal Article Deviant Behavior · January 1, 2010 This article examines family stress dynamics and conduct disorder trajectories prospectively in the lives of adolescents from the Great Smoky Mountains Study of Youth (n = 1,319). Semi-parametric mixture models are used to identify distinct trajectories of ... Full text Cite

Parents' Incomes and Children's Outcomes: A Quasi-Experiment.

Journal Article Am Econ J Appl Econ · January 2010 We examine the role that an exogenous increase in household income due to a government transfer unrelated to household characteristics plays in children's long run outcomes. Children in affected households have higher levels of education in their young adu ... Full text Open Access Link to item Cite

Transitions into underage and problem drinking: Summary of developmental processes and mechanisms: Ages 10-15

Journal Article Alcohol Research and Health · October 20, 2009 Adolescents ages 10-15 experience dramatic changes in their biological, cognitive, emotional, and social development as well as in their physical and social environments. These include the physiological and psychological changes associated with puberty; fu ... Cite

Measurement and design for life course studies of individual differences and development

Journal Article · September 1, 2009 This chapter reviews methods for studying individual differences across the life course. It starts from the position that even when a life course study is basically observational or descriptive, there is an underlying concern to understand more about causa ... Full text Cite

Childhood and adolescent psychiatric disorders as predictors of young adult disorders.

Journal Article Arch Gen Psychiatry · July 2009 CONTEXT: Most adults with a psychiatric disorder first met diagnostic criteria during childhood and/or adolescence, yet specific homotypic and heterotypic patterns of prediction have not been firmly established. OBJECTIVE: To establish which childhood and ... Full text Link to item Cite

Configurations of common childhood psychosocial risk factors.

Journal Article J Child Psychol Psychiatry · April 2009 BACKGROUND: Co-occurrence of psychosocial risk factors is commonplace, but little is known about psychiatrically-predictive configurations of psychosocial risk factors. METHODS: Latent class analysis (LCA) was applied to 17 putative psychosocial risk facto ... Full text Link to item Cite

Moving from ethnography to epidemiology: lessons learned in Appalachia.

Journal Article Ann Hum Biol · 2009 BACKGROUND: Anthropologists are beginning to translate insights from ethnography into tools for population studies that assess the role of culture in human behavior, biology, and health. AIM: We describe several lessons learned in the creation and administ ... Full text Link to item Cite

Nosology and measurement in child and adolescent psychiatry.

Journal Article J Child Psychol Psychiatry · January 2009 The last 50 years have witnessed enormous strides in the measurement and classification of child and adolescent psychiatric disorders. Debates about whether we should continue to depend upon a categorical nosology still continue, but we argue that, despite ... Full text Link to item Cite

Childhood psychopathology can be really bad for your health.

Journal Article J Am Acad Child Adolesc Psychiatry · January 2009 Full text Link to item Cite

Parent-reported attention-deficit/hyperactivity disorder symptomatology and sleep problems in a preschool-age pediatric clinic sample.

Journal Article J Am Acad Child Adolesc Psychiatry · September 2008 OBJECTIVE: To examine the association between attention-deficit/hyperactivity disorder symptomatology and parent-reported sleep problems among preschoolers ages 2 to 5 years. METHOD: A total of 1,073 parents of preschoolers ages 2 to 5 years attending a la ... Full text Link to item Cite

Cultural and community determinants of subjective social status among Cherokee and White youth.

Journal Article Ethn Health · September 2008 BACKGROUND: . Subjective social status (SSS) is associated with physical and mental health in diverse samples. However, community, cultural, and ethnic influences on SSS are poorly understood, especially among rural and American Indian populations. OBJECTI ... Full text Link to item Cite

Transitions into underage and problem drinking: developmental processes and mechanisms between 10 and 15 years of age.

Journal Article Pediatrics · April 2008 Numerous developmental changes occur across levels of personal organization (eg, changes related to puberty, brain and cognitive-affective structures and functions, and family and peer relationships) in the age period of 10 to 15 years. Furthermore, the on ... Full text Link to item Cite

Specificity of putative psychosocial risk factors for psychiatric disorders in children and adolescents.

Journal Article J Child Psychol Psychiatry · January 2008 BACKGROUND: Most psychosocial risk factors appear to have general rather than specific patterns of association with common childhood and adolescence disorders. However, previous research has typically failed to 1) control for comorbidity among disorders, 2 ... Full text Link to item Cite

What do childhood anxiety disorders predict?

Journal Article J Child Psychol Psychiatry · December 2007 BACKGROUND: Few longitudinal studies of child and adolescent psychopathology have examined the links between specific childhood anxiety disorders and adolescent psychiatric disorder. In this paper we test the predictive specificity of separation anxiety di ... Full text Link to item Cite

Childhood psychiatric disorders and young adult crime: a prospective, population-based study.

Journal Article Am J Psychiatry · November 2007 OBJECTIVE: While psychopathology is common in criminal populations, knowing more about what kinds of psychiatric disorders precede criminal behavior could be helpful in delineating at-risk children. The authors determined rates of juvenile psychiatric diso ... Full text Link to item Cite

Preschool psychopathology: lessons for the lifespan.

Journal Article J Child Psychol Psychiatry · October 2007 Full text Link to item Cite

Diagnostic specificity and nonspecificity in the dimensions of preschool psychopathology.

Journal Article J Child Psychol Psychiatry · October 2007 BACKGROUND: The appropriateness of the Diagnostic and Statistical Manual of Mental Disorders - Fourth Edition (DSM-IV) nosology for classifying preschool mental health disturbances continues to be debated. To inform this debate, we investigate whether pres ... Full text Link to item Cite

Traumatic events and posttraumatic stress in childhood.

Journal Article Arch Gen Psychiatry · May 2007 CONTEXT: Traumatic events are common and are related to psychiatric impairment in childhood. Little is known about the risk for posttraumatic stress disorder (PTSD) across different types of trauma exposure in children. OBJECTIVE: To examine the developmen ... Full text Link to item Cite

Pubertal maturation and the development of alcohol use and abuse.

Journal Article Drug Alcohol Depend · April 2007 OBJECTIVE: To examine the impact of various aspects of puberty on risk of using alcohol and developing alcohol use disorder (AUD). METHODS: Data come from the Great Smoky Mountains Study, a longitudinal study of a representative sample of 1420 youth aged 9 ... Full text Link to item Cite

Prediction from low birth weight to female adolescent depression: a test of competing hypotheses.

Journal Article Arch Gen Psychiatry · March 2007 CONTEXT: Low birth weight (LBW) predicts later-onset hypertension and diabetes mellitus. Its role as a predictor of depression is unclear. OBJECTIVES: To examine whether LBW predicts depression in male and female children and adolescents and to compare the ... Full text Link to item Cite

Differences among children whose mothers have been in contact with the criminal justice system

Journal Article Women and Criminal Justice · 2007 In order to effectively help children whose mothers become involved with the criminal justice system, it is important to understand their differing needs. To that end, the analyses described in this article explore the heterogeneity in parent and family ri ... Full text Cite

Is there an epidemic of child or adolescent depression?

Journal Article J Child Psychol Psychiatry · December 2006 BACKGROUND: Both the professional and the general media have recently published concerns about an 'epidemic' of child and adolescent depression. Reasons for this concern include (1) increases in antidepressant prescriptions, (2) retrospective recall by suc ... Full text Link to item Cite

Bayesian semi-parametric ROC analysis.

Journal Article Stat Med · November 30, 2006 This paper describes a semi-parametric Bayesian approach for estimating receiver operating characteristic (ROC) curves based on mixtures of Dirichlet process priors (MDP). We address difficulties in modelling the underlying distribution of screening scores ... Full text Link to item Cite

Prevalence, clinical correlates, and longitudinal course of severe mood dysregulation in children.

Journal Article Biol Psychiatry · November 1, 2006 BACKGROUND: Controversy concerning the diagnosis of pediatric bipolar disorder (BD) has focused attention on children with chronic irritability and hyperarousal. This syndrome has been called the "broad BD phenotype" or severe mood dysregulation (SMD). Thi ... Full text Link to item Cite

Puberty and depression.

Journal Article Child Adolesc Psychiatr Clin N Am · October 2006 Unipolar depression only becomes more common in girls than boys after the age of 13, as a result of an increased incidence of depressive episodes in girls at that time. This article reviews evidence that links multiple dimensions of maturation in the hypot ... Full text Link to item Cite

Proximal psychiatric risk factors for suicidality in youth: the Great Smoky Mountains Study.

Journal Article Arch Gen Psychiatry · September 2006 CONTEXT: Psychiatric disorder is a major risk factor for suicidality but has poor positive predictive value. OBJECTIVES: To characterize proximal risks for suicidality associated with anxiety, depressive, disruptive behavior, and substance use disorders, a ... Full text Link to item Cite

A comparison of pure and comorbid CD/ODD and depression.

Journal Article J Child Psychol Psychiatry · July 2006 BACKGROUND: We studied the symptomatology of conduct/oppositional defiant disorder and major depression/dysthymic disorder in 'pure' and comorbid presentations. METHOD: The sample comprised 382 children of 8 to 17 years of age attending for psychiatric out ... Full text Link to item Cite

Test-Retest Reliability of the Preschool Age Psychiatric Assessment (PAPA).

Journal Article J Am Acad Child Adolesc Psychiatry · May 2006 OBJECTIVE: To examine the test-retest reliability of a new interviewer-based psychiatric diagnostic measure (the Preschool Age Psychiatric Assessment) for use with parents of preschoolers aged 2 to 5 years. METHOD: A total of 1,073 parents of children atte ... Full text Link to item Cite

The epidemiology and diagnostic issues in preschool attention-deficit/ hyperactivity disorder: A review

Journal Article Infants and Young Children · January 1, 2006 This study aims to review the nosology and epidemiology of attention-deficit/hyperactivity disorder (ADHD) in children aged 2 through 5 years. Studies, primarily in community or pediatric clinic settings, were reviewed. In studies using DSM diagnostic crit ... Full text Cite

Common emotional and behavioral disorders in preschool children: presentation, nosology, and epidemiology.

Journal Article J Child Psychol Psychiatry · 2006 We review recent research on the presentation, nosology and epidemiology of behavioral and emotional psychiatric disorders in preschool children (children ages 2 through 5 years old), focusing on the five most common groups of childhood psychiatric disorde ... Full text Link to item Cite

10-year research update review: the epidemiology of child and adolescent psychiatric disorders: II. Developmental epidemiology.

Journal Article J Am Acad Child Adolesc Psychiatry · January 2006 OBJECTIVE: To describe the growth of developmental epidemiology in the past decade and to illustrate it with examples of recent studies. METHOD: A review of publications on developmental epidemiology in the past 10 years and a discussion of some key exampl ... Full text Link to item Cite

Defining oppositional defiant disorder.

Journal Article J Child Psychol Psychiatry · December 2005 BACKGROUND: ICD-10 and DSM-IV include similar criterial symptom lists for conduct disorder (CD) and oppositional defiant disorder (ODD), but while DSM-IV treats each list separately, ICD-10 considers them jointly. One consequence is that ICD-10 identifies ... Full text Link to item Cite

Application of Bayesian inference using Gibbs sampling to item-response theory modeling of multi-symptom genetic data.

Journal Article Behav Genet · November 2005 Several "genetic" item-response theory (IRT) models are fitted to the responses of 1086 adolescent female twins to the 33 multi-category item Mood and Feeling Questionnaire relating to depressive symptomatology in adolescence. A Markov-chain Monte Carlo (M ... Full text Link to item Cite

The developmental epidemiology of anxiety disorders: phenomenology, prevalence, and comorbidity.

Journal Article Child Adolesc Psychiatr Clin N Am · October 2005 This article argues that the quality of diagnostic tools used to measure anxiety disorders in children and adolescents has improved enormously in the past few years. As a result, prevalence estimates are less erratic, understanding of comorbidity is increa ... Full text Link to item Cite

10-year research update review: the epidemiology of child and adolescent psychiatric disorders: I. Methods and public health burden.

Journal Article J Am Acad Child Adolesc Psychiatry · October 2005 OBJECTIVE: To review recent progress in child and adolescent psychiatric epidemiology in the area of prevalence and burden. METHOD: The literature published in the past decade was reviewed under two headings: methods and findings. RESULTS: Methods for asse ... Full text Link to item Cite

Making sense of informant disagreement for overanxious disorder.

Journal Article J Anxiety Disord · 2005 A community sample of 2798 8-17-year-old twins and their parents completed a personal interview about the child's current psychiatric history on two occasions separated by an average of 18 months. Parents also completed a personal interview about their own ... Full text Link to item Cite

Distant Trauma: A prospective study of the effects of september 11th on young adults in North Carolina

Journal Article Applied Developmental Science · October 1, 2004 In 2001, 730 young adults (aged 19–21) were given a detailed assessment as part of an ongoing longitudinal, epidemiological study of the development of psychiatric disorders across childhood and adolescence. Each participant had been interviewed up to 6 ti ... Full text Cite

Genetic and environmental influences on the relative timing of pubertal change.

Journal Article Twin Res · October 2004 A multicategory item-response theory model was developed to characterize developmental changes in three items relating to the assessment of puberty in adolescent twin girls and boys. The model allowed for the fixed effects of age on probability of endorsin ... Full text Link to item Cite

Effects of age at first substance use and psychiatric comorbidity on the development of substance use disorders.

Journal Article Drug Alcohol Depend · September 6, 2004 In this paper, we examine the effects of age at first substance use, and history of psychiatric disorders, on the development of substance use disorder (SUD) by age 16. We use a prospective, longitudinal design to disaggregate the effects of age at first u ... Full text Link to item Cite

Informant disagreement for separation anxiety disorder.

Journal Article J Am Acad Child Adolesc Psychiatry · April 2004 OBJECTIVE: To characterize informant disagreement for separation anxiety disorder (SAD). METHOD: The sample comprised 2,779 8- to 17-year-old twins from a community-based registry. Children and their parents completed a personal interview about the child's ... Full text Link to item Cite

Testosterone, antisocial behavior, and social dominance in boys: pubertal development and biosocial interaction.

Journal Article Biol Psychiatry · March 1, 2004 BACKGROUND: Studies linking testosterone and antisocial behavior in humans have produced mixed results. Adolescence offers a promising period to study this relationship; circulating testosterone increases dramatically in boys during puberty, and antisocial ... Full text Link to item Cite

Pathways to violence in the children of mothers who were depressed postpartum.

Journal Article Dev Psychol · November 2003 The impact of postnatal depression on a child's risk for violent behavior was evaluated in an urban British community sample (N=122 families). Mothers were interviewed during pregnancy, at 3 months postpartum, and when the child was 1, 4, and 11 years of a ... Full text Link to item Cite

Relationships between poverty and psychopathology: a natural experiment.

Journal Article JAMA · October 15, 2003 CONTEXT: Social causation (adversity and stress) vs social selection (downward mobility from familial liability to mental illness) are competing theories about the origins of mental illness. OBJECTIVE: To test the role of social selection vs social causati ... Full text Link to item Cite

Relations between Continuous Performance Test performance measures and ADHD behaviors.

Journal Article J Abnorm Child Psychol · October 2003 The Conners' Continuous Performance Test (CPT) is a neuropsychological task that has repeatedly been shown to differentiate ADHD from normal groups. Several variables may be derived from the Conners' CPT including errors of omission and commission, mean hi ... Full text Link to item Cite

Continuous performance test performance in a normative epidemiological sample.

Journal Article J Abnorm Child Psychol · October 2003 A 14-min continuous performance test (CPT) requiring a high rate of responding was administered to a probability-weighted random sample of 816 9-17-year-old children drawn from a population of 17,117 children in an ongoing epidemiological and longitudinal ... Full text Link to item Cite

Prevalence and development of psychiatric disorders in childhood and adolescence.

Journal Article Arch Gen Psychiatry · August 2003 BACKGROUND: This longitudinal community study assessed the prevalence and development of psychiatric disorders from age 9 through 16 years and examined homotypic and heterotypic continuity. METHODS: A representative population sample of 1420 children aged ... Full text Link to item Cite

Mental health assessments in juvenile justice: report on the consensus conference.

Journal Article J Am Acad Child Adolesc Psychiatry · July 2003 OBJECTIVE: At national, state, and local levels, there is increasing recognition of the importance of identifying and responding to the mental health needs of youths in the juvenile justice system, as policymakers and practitioners struggle to find ways to ... Full text Link to item Cite

School refusal and psychiatric disorders: a community study.

Journal Article J Am Acad Child Adolesc Psychiatry · July 2003 OBJECTIVE: To examine the association between anxious school refusal and truancy and psychiatric disorders in a community sample of children and adolescents using a descriptive rather than etiological definition of school refusal. METHOD: Data from eight a ... Full text Link to item Cite

Obesity and psychiatric disorder: developmental trajectories.

Journal Article Pediatrics · April 2003 OBJECTIVES: To identify age-related trajectories of obesity from childhood into adolescence, and to test the association of these trajectories with the development of psychiatric disorders (conduct disorder, oppositional defiant disorder, attention-deficit ... Full text Link to item Cite

Maternal smoking during pregnancy and risk to boys' conduct disturbance: an examination of the causal hypothesis.

Journal Article Biol Psychiatry · January 15, 2003 BACKGROUND: We undertook this study to determine whether the widely replicated link between maternal smoking and conduct disturbance (Cd) is better explained by a model of direct causation or of mother-offspring transmission of a latent Cd variable. METHOD ... Full text Link to item Cite

Puberty and depression

Chapter · January 1, 2003 In this chapter we will examine evidence concerning the emergence of an excess of unipolar depression in females during adolescence. We will also present new data from the Great Smoky Mountains Study (GSMS) in support of an approach that combines considera ... Full text Cite

Pathways into and through mental health services for children and adolescents.

Journal Article Psychiatr Serv · January 2003 OBJECTIVE: This study examined points of entry into the mental health service system for children and adolescents as well as patterns of movement through five service sectors: specialty mental health services, education, general medicine, juvenile justice, ... Full text Link to item Cite

Natural categories or fundamental dimensions: on carving nature at the joints and the rearticulation of psychopathology.

Journal Article Dev Psychopathol · 2003 The question of whether to view psychopathology as categorical or dimensional continues to provoke debate. We review the many facets of this argument. These include the pragmatics of measurement; the needs of clinical practice; our ability to distinguish c ... Full text Link to item Cite

Depression scale scores in 8-17-year-olds: effects of age and gender.

Journal Article J Child Psychol Psychiatry · November 2002 BACKGROUND: The excess of unipolar depression in females emerges in adolescence. However, studies of age effects on depression scale scores have produced divergent estimates of changes from childhood to adolescence. METHOD: We explored possible reasons for ... Full text Link to item Cite

Psychiatric disorder, impairment, and service use in rural African American and white youth.

Journal Article Arch Gen Psychiatry · October 2002 BACKGROUND: The Caring for Children in the Community Study examined the prevalence of DSM-IV psychiatric disorders and correlates of mental health service use in rural African American and white youth. METHODS: Four thousand five hundred youth aged 9 to 17 ... Full text Link to item Cite

The prevalence of potentially traumatic events in childhood and adolescence.

Journal Article J Trauma Stress · April 2002 This paper examines exposure to potentially traumatic events from middle childhood through adolescence, and vulnerability to such exposure. Analyses are based on the first 4 annual waves of data from a longitudinal general population study of youth in west ... Full text Link to item Cite

The relationship between DSM-IV oppositional defiant disorder and conduct disorder: findings from the Great Smoky Mountains Study.

Journal Article J Child Psychol Psychiatry · March 2002 BACKGROUND: We examine models of the relationship between oppositional defiant disorder (ODD) and conduct disorder (CD) in a community sample. Particular attention is paid to the generalisability of findings based on clinic-referred boys. METHODS: The anal ... Full text Link to item Cite

Exposure to violence against a family member and internalizing symptoms in Colombian adolescents: the protective effects of family support.

Journal Article J Consult Clin Psychol · December 2001 Associations between exposure to serious violence against a family member and internalizing symptoms, and the protective effects of support from family versus friends, were examined in 5,775 adolescents (50% female; mean age = 15.2 years, SD = 2.0) with da ... Full text Link to item Cite

Epidemiology of psychiatric disability in childhood and adolescence.

Journal Article J Child Psychol Psychiatry · October 2001 The goal of the study was to ascertain the factor structure and prevalence of psychiatric disability in children and adolescents in relation to demographic variables and diagnosis. A representative sample of 1,420 children (9-13 years) from 11 countries in ... Full text Link to item Cite

Poverty, race/ethnicity, and psychiatric disorder: a study of rural children.

Journal Article Am J Public Health · September 2001 OBJECTIVES: This study examined the effect of poverty on the prevalence of psychiatric disorder in rural Black and White children. METHODS: A representative sample of 541 Black children and 379 White children aged 9 to 17 was drawn from 4 predominantly rur ... Full text Link to item Cite

Do high-threat life events really provoke the onset of psychiatric disorder in children?

Journal Article J Child Psychol Psychiatry · May 2001 Studies on adults have suggested important effects of stressful life events in provoking onset of psychiatric disorder. Only a few comparable studies on children exist, and their results are inconsistent in relation to definite timing effects. Meeting some ... Link to item Cite

Bayesian analyses of longitudinal binary data using Markov regression models of unknown order.

Journal Article Stat Med · March 15, 2001 We present non-homogeneous Markov regression models of unknown order as a means to assess the duration of autoregressive dependence in longitudinal binary data. We describe a subject's transition probability evolving over time using logistic regression mod ... Full text Link to item Cite

Multimodal treatment of ADHD in the MTA: an alternative outcome analysis.

Journal Article J Am Acad Child Adolesc Psychiatry · February 2001 OBJECTIVE: To conduct a post hoc investigation of the utility of a single composite measure of treatment outcome for the NIMH Collaborative Multisite Multimodal Treatment Study of Children With Attention-Deficit/Hyperactivity Disorder (MTA) at 14 months po ... Full text Link to item Cite

Effectiveness of mental health services

Journal Article Journal of the American Academy of Child and Adolescent Psychiatry · January 1, 2001 Full text Cite

Use of mental health services by youth in contact with social services

Journal Article Social Service Review · January 1, 2001 This article compares mental health service need and use among three groups of children: those with a history of foster care placement, those in contact with departments of social services but never in placement, and those from impoverished families who ha ... Full text Cite

Effectiveness of mental health services.

Journal Article J Am Acad Child Adolesc Psychiatry · January 2001 Full text Link to item Cite

Implications of early versus late onset of attention-deficit/hyperactivity disorder symptoms.

Journal Article J Am Acad Child Adolesc Psychiatry · December 2000 OBJECTIVE: The current diagnostic criteria for attention-deficit/hyperactivity disorder (ADHD) require that symptoms emerge prior to age 7 in order for a formal diagnosis to be considered. However, this age-of-onset criterion (AOC) has recently been questi ... Full text Link to item Cite

Stimulant treatment for children: a community perspective.

Journal Article J Am Acad Child Adolesc Psychiatry · August 2000 OBJECTIVE: To examine the use of prescribed stimulants in relation to research diagnoses of attention-deficit hyperactivity disorder (ADHD) in a community sample of children. METHOD: Data from 4 annual waves of interviews with 9- to 16-year-olds from the G ... Full text Link to item Cite

Effectiveness of nonresidential specialty mental health services for children and adolescents in the "real world".

Journal Article J Am Acad Child Adolesc Psychiatry · February 2000 OBJECTIVE: Although many studies demonstrate the efficacy of a variety of treatments for child and adolescent psychiatric disorders, studies showing the effectiveness of such treatments in ordinary clinical settings have not been forthcoming. This report p ... Full text Link to item Cite

The Child and Adolescent Psychiatric Assessment (CAPA).

Journal Article J Am Acad Child Adolesc Psychiatry · January 2000 OBJECTIVE: To describe the Child and Adolescent Psychiatric Assessment (CAPA). The base interview covers the age range from 9 to 17 years. METHOD: The interview glossary that provides detailed operational definitions of symptoms and severity ratings is des ... Full text Link to item Cite

Developmental psychopathology and public health: past, present, and future.

Journal Article Dev Psychopathol · 2000 Children's healthy mental development has never been the focus of long-term, committed public health policy in the way that early physical health and development have been. We discuss four types of societal response to illness-cure, care, control, and prev ... Full text Link to item Cite

Developmental Trajectories of Aggressive and Non-Aggressive Conduct Problems

Journal Article Journal of Quantitative Criminology · January 1, 2000 Modeling the heterogeneous trajectories along which antisocial behavior develops in childhood and adolescence may contribute in important ways to understanding antecedents of offending in adult life. This paper examines the development of aggressive and no ... Full text Cite

Epstein-Barr virus antibodies in whole blood spots: a minimally invasive method for assessing an aspect of cell-mediated immunity.

Journal Article Psychosom Med · 2000 OBJECTIVE: Study 1: Introduce and validate a method for measuring EBV p18-VCA antibodies in whole blood spots to provide a minimally invasive marker of cell-mediated immune function. Study 2: Apply this method to a large community-based study of psychopath ... Full text Link to item Cite

Assessing Functional Impairment and Social Adaptation for Child Mental Health Services Research: A Review of Measures

Journal Article Mental Health Services Research · December 1, 1999 The need for assessing impairment in functioning as an integral part of child mental health services research is discussed. Methodologic difficulties related to problems in case definition, the conceptual definition of impairment and social adaptation, and ... Full text Cite

Development of psychiatric comorbidity with substance abuse in adolescents: effects of timing and sex.

Journal Article J Clin Child Psychol · September 1999 Examined the impact of childhood psychiatric disorders on the prevalence and timing of substance use and abuse and tested for sex differences. A representative population sample of 1,420 children, ages 9, 11, and 13 at intake, were interviewed annually. Am ... Full text Link to item Cite

Pubertal changes in hormone levels and depression in girls.

Journal Article Psychol Med · September 1999 BACKGROUND: Throughout their reproductive years, women suffer from a higher prevalence of depression than men. Before puberty, however, this is not the case. In an earlier study, we found that reaching Tanner Stage III of puberty was associated with increa ... Full text Link to item Cite

Somatic complaints and psychopathology in children and adolescents: stomach aches, musculoskeletal pains, and headaches.

Journal Article J Am Acad Child Adolesc Psychiatry · July 1999 OBJECTIVE: To examine the associations of somatic complaints with DSM-III-R-defined depression, anxiety disorders, conduct disorder, oppositional defiant disorder, and attention-deficit hyperactivity disorder in a population-based sample of children and ad ... Full text Link to item Cite

Use, persistence, and intensity: patterns of care for children's mental health across one year.

Journal Article Community Ment Health J · February 1999 This paper explores the use, persistence, and intensity of services for children's mental health problems across a variety of service sectors during a one year period. Data come from the Great Smoky Mountains Study. Analyses focus on children's psychiatric ... Full text Link to item Cite

Impaired but undiagnosed.

Journal Article J Am Acad Child Adolesc Psychiatry · February 1999 OBJECTIVE: To investigate the prevalence and outcomes of individuals with psychosocial impairment not meeting DSM-III-R criteria for any of 29 well-defined disorders and to suggest operational definitions for not otherwise specified (NOS) diagnoses and V c ... Full text Link to item Cite

Adolescent outcomes of childhood disorders: the consequences of severity and impairment.

Journal Article J Am Acad Child Adolesc Psychiatry · February 1999 OBJECTIVE: To examine the adolescent consequences of clinical and threshold-level psychiatric disorders, with and without significant functional impairment; to predict serious emotional disturbance (SED: clinical-level diagnosis with impairment); and to ex ... Full text Link to item Cite

Life events and post-traumatic stress: the development of a new measure for children and adolescents.

Journal Article Psychol Med · November 1998 BACKGROUND: A new interview measure of life events and post-traumatic stress disorder (PTSD) has been developed for children and adolescents aged 9 through 17, for use in both epidemiological and clinical studies. It includes 'high magnitude' events associ ... Full text Link to item Cite

Headaches and psychopathology in children and adolescents.

Journal Article J Am Acad Child Adolesc Psychiatry · September 1998 OBJECTIVE: To examine the association between chronic headaches and DSM-III-R-defined psychiatric disorders, including depression, anxiety disorders, conduct disorder, oppositional defiant disorder and attention-deficit hyperactivity disorder, in a populat ... Full text Link to item Cite

Optimal Bayesian two-phase designs

Journal Article Journal of Statistical Planning and Inference · January 5, 1998 In this paper we present a Bayesian decision theoretic approach to the two-phase design problem. The solution of such sequential decision problems is usually difficult to obtain because of their reliance on preposterior analysis. In overcoming this problem ... Full text Cite

Perceived parental burden and service use for child and adolescent psychiatric disorders.

Journal Article Am J Public Health · January 1998 OBJECTIVES: Pediatric chronic physical illness and adult psychiatric disorders are substantial sources of burden for family care-takers, but little attention has been paid to parental burden resulting from children's or adolescents' psychiatric disorders. ... Full text Link to item Cite

Puberty and depression: the roles of age, pubertal status and pubertal timing.

Journal Article Psychol Med · January 1998 BACKGROUND: Previous work has indicated that the 2:1 female:male sex ratio in unipolar depressive disorders does not emerge until some time between ages 10 and 15. METHODS: Data from four annual waves of data collection from the Great Smoky Mountains Study ... Full text Link to item Cite

Psychiatric disorders among American Indian and white youth in Appalachia: the Great Smoky Mountains Study.

Journal Article Am J Public Health · May 1997 OBJECTIVES: This study examined prevalence of psychiatric disorders, social and family risk factors for disorders, and met and unmet needs for mental health care among Appalachian youth. METHODS: All 9-, 11-, and 13-year-old American Indian children in an ... Full text Link to item Cite

Development of substance use and psychiatric comorbidity in an epidemiologic study of white and American Indian young adolescents the Great Smoky Mountains Study.

Journal Article Drug Alcohol Depend · March 14, 1997 The progression of substance use and the patterns of comorbidity of substance use and psychiatric disorders are explored prospectively in young adolescents enrolled in the Great Smoky Mountains Study. This study is an epidemiologic study of white and Ameri ... Full text Link to item Cite

Insurance coverage and mental health services use by adolescents with serious emotional disturbance

Journal Article Journal of Child and Family Studies · January 1, 1997 This paper examines the relationships between insurance coverage, need, and mental health services in a community-based sample of 1,015youths who were 9, 11, and 13 years old at the beginning of the study. They were followed over a two-year period. A stron ... Full text Cite

Impact of Children's Mental Health Problems on Families: Relationships with Service Use

Journal Article Journal of Emotional and Behavioral Disorders · January 1, 1997 Impact on the family resulting from children's emotional and behavioral problems, with particular attention to relationships between such family impact and use of mental health services, is explored in this article. Data come from the Great Smoky Mountains ... Full text Cite

The relative diagnostic utility of child and parent reports of oppositional defiant behaviors

Journal Article International Journal of Methods in Psychiatric Research · January 1, 1997 It has been suggested that parents are better reporters of oppositional defiant behaviors than are children themselves and that this may be a reason to ignore child reports in the assessment of Oppositional Defiant Disorder (ODD). Using data from the Great ... Full text Cite

The child and adolescent burden assessment (CABA): Measuring the family impact of emotional and behavioral problems

Journal Article International Journal of Methods in Psychiatric Research · January 1, 1997 Background: Though adult psychiatric disorders have been found to be substantial sources of burden for family caretakers, little attention has been paid to the measurement of burden resulting from children's psychiatric disturbance, or to its measurement. ... Full text Cite

The Great Smoky Mountains Study of Youth. Goals, design, methods, and the prevalence of DSM-III-R disorders.

Journal Article Arch Gen Psychiatry · December 1996 BACKGROUND: The Great Smoky Mountains Study of youth focuses on the relationship between the development of psychiatric disorder and the need for and use of mental health services. METHODS: A multistage, overlapping cohorts design was used, in which 4500 o ... Full text Link to item Cite

Development of a short questionnaire for use in epidemiological studies of depression in children and adolescents: factor composition and structure across development

Journal Article International Journal of Methods in Psychiatric Research · December 1, 1996 In the present study, the factor composition of a new, brief, easy-to-administer, depression inventory for children and adolescents, the Short Mood and Feelings Questionnaire (SMFQ), was examined. Using longitudinal data from the Pittsburgh Youth Study, co ... Cite

Development of a short questionnaire for use in epidemiological studies of depression in children and adolescents

Journal Article International Journal of Methods in Psychiatric Research · December 1, 1996 The purpose of the present study was to describe the development and assess the psychometric properties of the Short Mood and Feelings Questionnaire (SMFQ). The SMFQ is a brief, easy-to-administer, self-report measure of childhood and adolescent depression ... Cite

Precision, reliability and accuracy in the dating of symptom onsets in child and adolescent psychopathology.

Journal Article J Child Psychol Psychiatry · September 1996 Dates of onset of psychiatric symptoms are required in determining whether diagnostic criteria are met for a number of disorders and for a variety of research questions. However, little attention has been paid to the precision and reliability of their reca ... Full text Link to item Cite

Toward establishing an empirical basis for the diagnosis of oppositional defiant disorder.

Journal Article J Am Acad Child Adolesc Psychiatry · September 1996 OBJECTIVES: (1) To determine the frequency of occurrence of oppositional defiant behaviors in the general population with a view to establishing empirical frequency cutoffs for the evaluation of oppositional defiant disorder (ODD). (2) To examine the effec ... Full text Link to item Cite

The Child and Adolescent Services Assessment (CASA): Description and Psychometrics

Journal Article Journal of Emotional and Behavioral Disorders · January 1, 1996 The Child and Adolescent Services Assessment (CASA) is a self- and parent-report instrument designed to assess the use of mental health services by children ages 8 years to 18 years. The CASA includes 31 settings covering inpatiem, outpatient, and informal ... Full text Cite

Disappearing Depression in a Population Sample of Boys

Journal Article Journal of Emotional and Behavioral Disorders · January 1, 1996 Although there is evidence that rules of depressive disorders increase during adolescence in girls, the data on the effects of age on depression in boys have been contradictory. In order to shed further light on this issue, the Short Mood and Feelings Ques ... Full text Cite

A test-retest reliability study of child-reported psychiatric symptoms and diagnoses using the Child and Adolescent Psychiatric Assessment (CAPA-C).

Journal Article Psychol Med · July 1995 Seventy-seven 10-18-year-old psychiatric in-patients and out-patients took part in a test-retest study of the Child and Adolescent Psychiatric Assessment (CAPA). They were interviewed on two occasions several days apart. Overall reliability of diagnosis ra ... Full text Link to item Cite

The Child and Adolescent Psychiatric Assessment (CAPA).

Journal Article Psychol Med · July 1995 Great advances have been made during the last 20 years in the development of structured and semi-structured interviews for use with psychiatric patients. However, in the field of child and adolescent psychiatry there have been weaknesses in the specificati ... Full text Link to item Cite

Children's mental health service use across service sectors.

Journal Article Health Aff (Millwood) · 1995 This DataWatch explores the roles of human service sectors (mental health, education, health, child welfare, and juvenile justice) in providing mental health services for children. The data are from the first wave of the Great Smoky Mountains Study of Yout ... Full text Link to item Cite

Developmental epidemiology.

Journal Article Epidemiol Rev · 1995 Full text Link to item Cite

Epidemiology and health care reform.

Journal Article J Am Acad Child Adolesc Psychiatry · September 1994 Full text Link to item Cite

Reliability of self-reported service use: Test-retest consistency of children's responses to the Child and Adolescent Services Assessment (CASA)

Journal Article Journal of Child and Family Studies · September 1, 1994 This paper reports on the reliability of children's responses on the Child and Adolescent Services Assessment (CASA) - a self-report instrument for use with 8- to 18-year-olds that gathers information about services used to address mental health problems. ... Full text Cite

Depressive comorbidity in children and adolescents: empirical, theoretical, and methodological issues.

Journal Article Am J Psychiatry · December 1993 OBJECTIVE: The purpose of the study was to examine comorbidity in the context of child and adolescent depression. METHOD: The authors reviewed recent epidemiological studies using standardized interviews and DSM-III or DSM-III-R criteria. RESULTS: There wa ... Full text Link to item Cite

How can epidemiology improve mental health services for children and adolescents?

Journal Article J Am Acad Child Adolesc Psychiatry · November 1993 Epidemiology, the study of patterns of disease distribution in time and space, can help to improve mental health services for children and adolescents by increasing understanding of the causes, development, and course of psychiatric disorders. For the purp ... Full text Link to item Cite

Seclusion on an adolescent unit.

Journal Article J Child Psychol Psychiatry · September 1993 We studied the seclusion records of an adolescent unit for a six-year period. Problems in the analysis of typical seclusion data are examined and statistical methods that overcame them are explained. Only a few relationships were found between the seclusio ... Full text Link to item Cite

Puberty onset of gender differences in rates of depression: a developmental, epidemiologic and neuroendocrine perspective.

Journal Article J Affect Disord · 1993 A dramatic feature of the epidemiology of depression is the appearance of a 2:1 female excess of depression during adolescence. In childhood, rates of depression either do not differ between boys and girls or show a slight excess in boys. In this paper we ... Full text Link to item Cite

Toward a developmental epidemiology of the disruptive behavior disorders

Journal Article Development and Psychopathology · January 1, 1993 Epidemiology, the study of patterns of disease distribution in time and space, offers a powerful set of theories and methods for understanding and preventing illness. The disruptive behavior disorders (DBDs) can be studied from the point of view of whether ... Full text Cite

Effects of age and pubertal status on depression in a large clinical sample

Journal Article Development and Psychopathology · January 1, 1992 The rate of depression rises overall between childhood and adolescence, and by early adulthood depression is twice as common in women as in men. However, study results are conflicting as to the relative rates of depression in prepubertal boys and girls, an ... Full text Cite

Mood variability in adolescents: a study of depressed, nondepressed and comorbid patients.

Journal Article J Affect Disord · December 1991 In a study to examine the variability of mood in psychiatrically disturbed adolescents, 30 inpatients aged 13-17 reported on current depressive symptoms three times a day for seven consecutive days, using a set of visual analog scales (the Adolescent Mood ... Full text Link to item Cite

The effects of age and sex on depression ratings in children and adolescents.

Journal Article J Am Acad Child Adolesc Psychiatry · January 1991 The self-reports of depressive symptomatology of the 89 children and the parental reports of 62 parents whose children had such symptoms from a sample of 220 children, aged 6 to 23 years, in a family-genetic study of children at high and low risk of depres ... Full text Link to item Cite

Seclusion.

Journal Article Br J Psychiatry · April 1989 Seclusion is a commonly used management technique in some areas of psychiatric practice. However, its theoretical and empirical underpinnings are greatly wanting in many respects. This paper reviews the present state of our knowledge and ignorance about se ... Full text Link to item Cite

Scales to assess child and adolescent depression: checklists, screens, and nets.

Journal Article J Am Acad Child Adolesc Psychiatry · November 1988 Full text Link to item Cite

Childhood and adolescent depression. II: Research in clinical populations.

Journal Article Br J Psychiatry · October 1988 The tremendous increase in interest in childhood and adolescent depression that has occurred since the early 1970s has resulted in a large and contradictory literature. Development of the concept of childhood depression, and the many clinical studies of de ... Full text Link to item Cite

Childhood and adolescent depression. I. Epidemiological and aetiological aspects.

Journal Article Br J Psychiatry · May 1988 Depression in childhood and adolescence has become a topic of considerable research interest in the last decade. A number of studies ranging over the last half-century provide information about the prevalence of depressive symptoms and syndromes in non-ref ... Full text Link to item Cite

Parent and child reports of depressive symptoms in children at low and high risk of depression.

Journal Article J Child Psychol Psychiatry · November 1987 The K-SADS-E psychiatric interview was administered to children and parents (N = 220) from families containing proband parents who had previously been depressed or who were normal. Agreement between parents and their children about depressive symptoms in t ... Full text Link to item Cite

Depressed parents and their children. General health, social, and psychiatric problems.

Journal Article Am J Dis Child · August 1986 Two hundred twenty children (aged 6 to 23 years) from families with either depressed or normal (nonpsychiatrically ill) parents of comparable sociodemographic backgrounds were studied. The children from families in which at least one parent had experienced ... Full text Link to item Cite

CHILDHOOD DEPRESSION

Journal Article The Lancet · June 23, 1984 Full text Cite