Scholars@Duke
Andrew Serghios Barbas

Andrew Serghios Barbas

Associate Professor of Surgery
Surgery, Abdominal Transplant Surgery
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Selected Publications

Optimizing DCD Liver Grafts With Prolonged Warm Ischemic Time Using Stabilized Plasmin in a Static Cold Storage Orthotopic Rat Liver Transplant Model.

Journal Article Transplant Direct · August 2024 BACKGROUND: The clinical success of liver transplantation has led to increased demand, requiring further expansion of the donor pool. Therapeutic interventions to optimize organs from donation after circulatory death (DCD) have significant potential to mit ... Full text Link to item Cite

Prolonged xenokidney graft survival in sensitized NHP recipients by expression of multiple human transgenes in a triple knockout pig.

Journal Article Sci Transl Med · June 12, 2024 Genetic modification of porcine donors, combined with optimized immunosuppression, has been shown to improve outcomes of experimental xenotransplant. However, little is known about outcomes in sensitized recipients, a population that could potentially bene ... Full text Link to item Cite

Subnormothermic Oxygenated Machine Perfusion (24 h) in DCD Kidney Transplantation.

Journal Article Transplant Direct · June 2024 BACKGROUND: Ex vivo kidney perfusion is an evolving platform that demonstrates promise in preserving and rehabilitating the kidney grafts. Despite this, there is little consensus on the optimal perfusion conditions. Hypothermic perfusion offers limited fun ... Full text Link to item Cite

Gene delivery followed by ex vivo lung perfusion using an adeno-associated viral vector in a rodent lung transplant model.

Journal Article J Thorac Cardiovasc Surg · May 2024 OBJECTIVE: Ex vivo lung perfusion has emerged as a platform for organ preservation, evaluation, and restoration. Gene delivery using a clinically relevant adeno-associated vector during ex vivo lung perfusion may be useful in optimizing donor allografts wh ... Full text Link to item Cite

Contemporary trends and outcomes after liver transplantation and resection for intrahepatic cholangiocarcinoma.

Journal Article J Gastrointest Surg · May 2024 BACKGROUND: Liver transplantation (LT) has been shown to be superior to resection in highly selected patients with perihilar cholangiocarcinoma (CCA), yet has traditionally been contraindicated for intrahepatic CCA (iCCA). Herein, we aimed to examine conte ... Full text Link to item Cite

What Is Hot and New in Basic and Translational Science in Liver Transplantation in 2023? Report of the Basic and Translational Research Committee of the International Liver Transplantation Society.

Journal Article Transplantation · May 1, 2024 The 2023 Joint Annual Congress of the International Liver Transplantation Society, European Liver and Intestine Transplant Association, and Liver Intensive Care Group of Europe were held in Rotterdam, the Netherlands, from May 3 to 6, 2023. This year, all ... Full text Link to item Cite

Comparison of the effects of normothermic machine perfusion and cold storage preservation on porcine intestinal allograft regenerative potential and viability.

Conference Am J Transplant · April 2024 Intestinal transplantation (IT) is the final treatment option for intestinal failure. Static cold storage (CS) is the standard preservation method used for intestinal allografts. However, CS and subsequent transplantation induce ischemia-reperfusion injury ... Full text Link to item Cite

Limitations of antifungal prophylaxis in preventing invasive Candida surgical site infections after liver transplant surgery.

Journal Article Antimicrob Agents Chemother · March 6, 2024 Invasive primary Candida surgical site infections (IP-SSIs) are a common complication of liver transplantation, and targeted antifungal prophylaxis is an efficient strategy to limit their occurrence. We performed a retrospective single-center cohort study ... Full text Link to item Cite

Normothermic Machine Perfusion of Donor Livers for Transplantation in the United States: A Randomized Controlled Trial.

Journal Article Ann Surg · November 1, 2023 OBJECTIVE: To compare conventional low-temperature storage of transplant donor livers [static cold storage (SCS)] with storage of the organs at physiological body temperature [normothermic machine perfusion (NMP)]. BACKGROUND: The high success rate of live ... Full text Link to item Cite

Adeno-associated virus mediates gene transduction after static cold storage treatment in rodent lung transplantation.

Conference J Thorac Cardiovasc Surg · July 2023 OBJECTIVE: Adeno-associated virus is a clinically used gene therapy vector but has not been studied in lung transplantation. We sought to determine the efficacy of adeno-associated virus delivery during static cold storage via the airway versus the pulmona ... Full text Link to item Cite

Development and validation of a REcurrent Liver cAncer Prediction ScorE (RELAPSE) following liver transplantation in patients with hepatocellular carcinoma: Analysis of the US Multicenter HCC Transplant Consortium.

Journal Article Liver Transpl · July 1, 2023 HCC recurrence following liver transplantation (LT) is highly morbid and occurs despite strict patient selection criteria. Individualized prediction of post-LT HCC recurrence risk remains an important need. Clinico-radiologic and pathologic data of 4981 pa ... Full text Link to item Cite

Optimizing DCD Liver Grafts With Prolonged Warm Ischemic Time Using Stabilized Plasmin in a Static Cold Storage Orthotopic Rat Liver Transplant Model.

Journal Article Transplant Direct · August 2024 BACKGROUND: The clinical success of liver transplantation has led to increased demand, requiring further expansion of the donor pool. Therapeutic interventions to optimize organs from donation after circulatory death (DCD) have significant potential to mit ... Full text Link to item Cite

Prolonged xenokidney graft survival in sensitized NHP recipients by expression of multiple human transgenes in a triple knockout pig.

Journal Article Sci Transl Med · June 12, 2024 Genetic modification of porcine donors, combined with optimized immunosuppression, has been shown to improve outcomes of experimental xenotransplant. However, little is known about outcomes in sensitized recipients, a population that could potentially bene ... Full text Link to item Cite

Subnormothermic Oxygenated Machine Perfusion (24 h) in DCD Kidney Transplantation.

Journal Article Transplant Direct · June 2024 BACKGROUND: Ex vivo kidney perfusion is an evolving platform that demonstrates promise in preserving and rehabilitating the kidney grafts. Despite this, there is little consensus on the optimal perfusion conditions. Hypothermic perfusion offers limited fun ... Full text Link to item Cite

Gene delivery followed by ex vivo lung perfusion using an adeno-associated viral vector in a rodent lung transplant model.

Journal Article J Thorac Cardiovasc Surg · May 2024 OBJECTIVE: Ex vivo lung perfusion has emerged as a platform for organ preservation, evaluation, and restoration. Gene delivery using a clinically relevant adeno-associated vector during ex vivo lung perfusion may be useful in optimizing donor allografts wh ... Full text Link to item Cite

Contemporary trends and outcomes after liver transplantation and resection for intrahepatic cholangiocarcinoma.

Journal Article J Gastrointest Surg · May 2024 BACKGROUND: Liver transplantation (LT) has been shown to be superior to resection in highly selected patients with perihilar cholangiocarcinoma (CCA), yet has traditionally been contraindicated for intrahepatic CCA (iCCA). Herein, we aimed to examine conte ... Full text Link to item Cite

What Is Hot and New in Basic and Translational Science in Liver Transplantation in 2023? Report of the Basic and Translational Research Committee of the International Liver Transplantation Society.

Journal Article Transplantation · May 1, 2024 The 2023 Joint Annual Congress of the International Liver Transplantation Society, European Liver and Intestine Transplant Association, and Liver Intensive Care Group of Europe were held in Rotterdam, the Netherlands, from May 3 to 6, 2023. This year, all ... Full text Link to item Cite

Comparison of the effects of normothermic machine perfusion and cold storage preservation on porcine intestinal allograft regenerative potential and viability.

Conference Am J Transplant · April 2024 Intestinal transplantation (IT) is the final treatment option for intestinal failure. Static cold storage (CS) is the standard preservation method used for intestinal allografts. However, CS and subsequent transplantation induce ischemia-reperfusion injury ... Full text Link to item Cite

Limitations of antifungal prophylaxis in preventing invasive Candida surgical site infections after liver transplant surgery.

Journal Article Antimicrob Agents Chemother · March 6, 2024 Invasive primary Candida surgical site infections (IP-SSIs) are a common complication of liver transplantation, and targeted antifungal prophylaxis is an efficient strategy to limit their occurrence. We performed a retrospective single-center cohort study ... Full text Link to item Cite

Normothermic Machine Perfusion of Donor Livers for Transplantation in the United States: A Randomized Controlled Trial.

Journal Article Ann Surg · November 1, 2023 OBJECTIVE: To compare conventional low-temperature storage of transplant donor livers [static cold storage (SCS)] with storage of the organs at physiological body temperature [normothermic machine perfusion (NMP)]. BACKGROUND: The high success rate of live ... Full text Link to item Cite

Adeno-associated virus mediates gene transduction after static cold storage treatment in rodent lung transplantation.

Conference J Thorac Cardiovasc Surg · July 2023 OBJECTIVE: Adeno-associated virus is a clinically used gene therapy vector but has not been studied in lung transplantation. We sought to determine the efficacy of adeno-associated virus delivery during static cold storage via the airway versus the pulmona ... Full text Link to item Cite

Development and validation of a REcurrent Liver cAncer Prediction ScorE (RELAPSE) following liver transplantation in patients with hepatocellular carcinoma: Analysis of the US Multicenter HCC Transplant Consortium.

Journal Article Liver Transpl · July 1, 2023 HCC recurrence following liver transplantation (LT) is highly morbid and occurs despite strict patient selection criteria. Individualized prediction of post-LT HCC recurrence risk remains an important need. Clinico-radiologic and pathologic data of 4981 pa ... Full text Link to item Cite

Incidence of Postreperfusion Hyperfibrinolysis in Liver Transplantation by Donor Type and Observed Treatment Strategies.

Journal Article Anesth Analg · March 1, 2023 BACKGROUND: Hyperfibrinolysis is a possible complication during liver transplantation, particularly immediately after reperfusion. METHODS: We performed a retrospective study to examine the incidence, treatment, and resolution of postreperfusion hyperfibri ... Full text Open Access Link to item Cite

American Society of Transplant Surgeons recommendations on best practices in donation after circulatory death organ procurement.

Journal Article Am J Transplant · February 2023 The American Society of Transplant Surgeons supports efforts to increase the number of organs that are critically needed for patients desperately awaiting transplantation. In the United States, transplantation using organs procured from donation after circ ... Full text Link to item Cite

Textbook Outcome: Definition and Analysis of a Novel Quality Measure in Lung Transplantation.

Journal Article Ann Surg · February 1, 2023 OBJECTIVE: To define textbook outcome (TO) for lung transplantation (LTx) using a contemporary cohort from a high-volume institution. SUMMARY BACKGROUND DATA: TO is a standardized, composite quality measure based on multiple postoperative endpoints represe ... Full text Link to item Cite

AAV9 PD-L1 Mediated Immunodulation of Donor Graft in Rat Lung Allotransplantation

Conference JOURNAL OF HEART AND LUNG TRANSPLANTATION · 2023 Cite

Sterile inflammation in liver transplantation.

Journal Article Front Med (Lausanne) · 2023 Sterile inflammation is the immune response to damage-associated molecular patterns (DAMPs) released during cell death in the absence of foreign pathogens. In the setting of solid organ transplantation, ischemia-reperfusion injury results in mitochondria-m ... Full text Link to item Cite

Orthotopic Transplantation of the Full-length Porcine Intestine After Normothermic Machine Perfusion.

Journal Article Transplant Direct · November 2022 UNLABELLED: Successful intestinal transplantation is currently hindered by graft injury that occurs during procurement and storage, which contributes to postoperative sepsis and allograft rejection. Improved graft preservation may expand transplantable gra ... Full text Open Access Link to item Cite

Subnormothermic ex vivo lung perfusion attenuates graft inflammation in a rat transplant model.

Journal Article J Thorac Cardiovasc Surg · August 2022 OBJECTIVE: Ex vivo lung perfusion has emerged as a novel technique to safely preserve lungs before transplantation. Recent studies have demonstrated an accumulation of inflammatory molecules in the perfusate during ex vivo lung perfusion. These proinflamma ... Full text Link to item Cite

Robotic Living Donor Right Hepatectomy: A Systematic Review and Meta-Analysis.

Journal Article J Clin Med · May 5, 2022 The introduction of robotics in living donor liver transplantation has been revolutionary. We aimed to examine the safety of robotic living donor right hepatectomy (RLDRH) compared to open (ODRH) and laparoscopic (LADRH) approaches. A systematic review was ... Full text Link to item Cite

Center variations in patient selection for simultaneous heart-kidney transplantation.

Journal Article Clin Transplant · May 2022 UNLABELLED: There are no established regulations governing patient selection for simultaneous heart-kidney (SHK) transplantation, creating the potential for significant center-level variations in clinical practice. METHODS: Using the United Network for Org ... Full text Link to item Cite

Textbook surgical outcome in lung transplantation: Analysis of a US national registry.

Journal Article Clin Transplant · April 2022 INTRO: Textbook surgical outcome (TO) is a novel composite quality measure in lung transplantation (LTx). Compared to 1-year survival metrics, TO may better differentiate center performance, and motivate improvements in care. To understand the feasibility ... Full text Link to item Cite

Lung transplantation after ex vivo lung perfusion versus static cold storage: An institutional cost analysis.

Journal Article Am J Transplant · February 2022 Ex vivo lung perfusion (EVLP) is a novel lung preservation strategy that facilitates the use of marginal allografts; however, it is more expensive than static cold storage (SCS). To understand how preservation method might affect postoperative costs, we co ... Full text Link to item Cite

SARS-CoV-2 infection and venous thromboembolism after surgery: an international prospective cohort study.

Journal Article Anaesthesia · January 2022 SARS-CoV-2 has been associated with an increased rate of venous thromboembolism in critically ill patients. Since surgical patients are already at higher risk of venous thromboembolism than general populations, this study aimed to determine if patients wit ... Full text Link to item Cite

Renal Failure After Primary Organ Transplantation

Conference AMERICAN JOURNAL OF TRANSPLANTATION · 2022 Cite

Two Compartment Evaluation of Liver Grafts During Acellular Room Temperature Machine Perfusion (acRTMP) in a Rat Liver Transplant Model.

Journal Article Front Med (Lausanne) · 2022 BACKGROUND: Subnormothermic machine perfusion (SNMP) of liver grafts is currently less clinically developed than normothermic and hypothermic approaches, but may have logistical advantages. At intermediate temperatures, the oxygen demand of the graft is lo ... Full text Link to item Cite

The Synergistic Role of Irreversible Electroporation and Chemotherapy for Locally Advanced Pancreatic Cancer.

Journal Article Front Oncol · 2022 Irreversible electroporation (IRE) is a local ablative technique used in conjunction with chemotherapy to treat locally advanced pancreatic cancer (LAPC). The combination of IRE and chemotherapy has showed increased overall survival when compared to chemot ... Full text Link to item Cite

Gene Therapy: Will the Promise of Optimizing Lung Allografts Become Reality?

Journal Article Front Immunol · 2022 Lung transplantation is the definitive therapy for patients living with end-stage lung disease. Despite significant progress made in the field, graft survival remains the lowest of all solid organ transplants. Additionally, the lung has among the lowest of ... Full text Link to item Cite

Complement-targeting therapeutics for ischemia-reperfusion injury in transplantation and the potential for ex vivo delivery.

Journal Article Front Immunol · 2022 Organ shortages and an expanding waitlist have led to increased utilization of marginal organs. All donor organs are subject to varying degrees of IRI during the transplant process. Extended criteria organs, including those from older donors and organs don ... Full text Link to item Cite

Liver Transplantation for Hepatocellular Carcinoma after Downstaging or Bridging Therapy with Immune Checkpoint Inhibitors.

Journal Article Cancers (Basel) · December 15, 2021 Liver transplantation offers excellent outcomes for patients with HCC. For those who initially present within the Milan criteria, bridging therapy is essential to control disease while awaiting liver transplant. For those who present beyond the Milan crite ... Full text Link to item Cite

Left lateral segment liver volume is not correlated with anthropometric measures.

Journal Article HPB (Oxford) · December 2021 BACKGROUND: Liver transplantation is definitive therapy for end stage liver disease in pediatric patients. Living donor liver transplantation (LDLT) with the left lateral segment (LLS) is often a feasible option. However, the size of LLS is an important fa ... Full text Link to item Cite

A Historical Cohort in Kidney Transplantation: 55-Year Follow-Up of 72 HLA-Identical, Donor-Recipient Pairs.

Journal Article J Clin Med · November 24, 2021 The impact of HLA matching on graft survival has been well characterized in renal transplantation, with a higher degree of matching associated with superior graft survival. Additionally, living donor grafts are known to confer superior survival compared to ... Full text Link to item Cite

Duct of Luschka Bile Leak Following Deceased Donor Liver Transplant.

Journal Article Am J Case Rep · October 25, 2021 BACKGROUND Biliary leak is a relatively uncommon but potentially severe complication of liver transplantation. Duct of Luschka (also known as subvesical bile ducts) is a term that refers to a number of accessory biliary ducts. While leaks from Ducts of Lus ... Full text Link to item Cite

SARS-CoV-2 vaccination modelling for safe surgery to save lives: data from an international prospective cohort study.

Journal Article Br J Surg · September 27, 2021 BACKGROUND: Preoperative SARS-CoV-2 vaccination could support safer elective surgery. Vaccine numbers are limited so this study aimed to inform their prioritization by modelling. METHODS: The primary outcome was the number needed to vaccinate (NNV) to prev ... Full text Link to item Cite

Point-of-Care Assessment of DCD Livers During Normothermic Machine Perfusion in a Nonhuman Primate Model.

Journal Article Hepatol Commun · September 2021 Normothermic machine perfusion (NMP) provides clinicians an opportunity to assess marginal livers before transplantation. However, objective criteria and point-of-care (POC) biomarkers to predict risk and guide decision making are lacking. In this investig ... Full text Link to item Cite

Reexamining Risk Aversion: Willingness to Pursue and Utilize Nonideal Donor Livers Among US Donation Service Areas.

Journal Article Transplant Direct · September 2021 BACKGROUND: Livers from "nonideal" but acceptable donors are underutilized; however, organ procurement organization (OPO) metrics do not assess how OPO-specific practices contribute to these trends. In this analysis, we evaluated nonideal liver donor avoid ... Full text Link to item Cite

The Impact of the 2017 Kidney Allocation Policy Change on Simultaneous Liver-Kidney Utilization and Outcomes.

Journal Article Liver Transpl · August 2021 Historically in the United States, kidneys for simultaneous liver-kidney transplantation (SLKT) candidates were allocated with livers, prioritizing SLKT recipients over much of the kidney waiting list. A 2017 change in policy delineated renal function crit ... Full text Link to item Cite

Need for improvements in simultaneous heart-kidney allocation: The limitation of pretransplant glomerular filtration rate.

Journal Article Am J Transplant · July 2021 The incidence of simultaneous heart-kidney transplant (SHK) has increased markedly in the last 15 years. There are no universally agreed upon indications for SHK vs. heart alone (HA) transplant, and center evaluation processes vary widely. We utilized Scie ... Full text Link to item Cite

Systemic Complement Activation in Donation After Brain Death Versus Donation After Circulatory Death Organ Donors.

Journal Article Exp Clin Transplant · July 2021 OBJECTIVES: Complement activation in organs from deceased donors is associated with allograft injury and acute rejection. Because use of organs from donors after circulatory death is increasing, we characterized relative levels of complement activation in ... Full text Link to item Cite

A simple scoring system to estimate perioperative mortality following liver resection for primary liver malignancy-the Hepatectomy Risk Score (HeRS).

Journal Article Hepatobiliary Surg Nutr · June 2021 BACKGROUND: Selection of the optimal treatment modality for primary liver cancers remains complex, balancing patient condition, liver function, and extent of disease. In individuals with preserved liver function, liver resection remains the primary approac ... Full text Link to item Cite

Definition and Analysis of Textbook Outcome: A Novel Quality Measure in Kidney Transplantation.

Journal Article World J Surg · May 2021 BACKGROUND: "Textbook outcome" (TO) is a novel composite quality measure that encompasses multiple postoperative endpoints, representing the ideal "textbook" hospitalization for complex surgical procedures. We defined TO for kidney transplantation using a ... Full text Link to item Cite

Immunological organ modification during Ex Vivo machine perfusion: The future of organ acceptance.

Journal Article Transplant Rev (Orlando) · April 2021 Ex vivo machine perfusion (EVMP) has gained revitalized interest in recent years due to the increasing use of marginal organs which poorly tolerate the standard preservation method static cold storage (SCS). EVMP improves on SCS in a number of ways, most n ... Full text Link to item Cite

Textbook Outcomes in Liver Transplantation.

Journal Article World J Surg · April 2021 Full text Link to item Cite

Diagnostic, Predictive and Prognostic Molecular Biomarkers in Pancreatic Cancer: An Overview for Clinicians.

Journal Article Cancers (Basel) · March 3, 2021 Pancreatic ductal adenocarcinoma (PDAC) is the most common pancreatic malignancy and is associated with aggressive tumor behavior and poor prognosis. Most patients with PDAC present with an advanced disease stage and treatment-resistant tumors. The lack of ... Full text Link to item Cite

Preemptive VAE-An Important Tool for Managing Blood Loss in MVT Candidates With PMT.

Journal Article Transplant Direct · March 2021 UNLABELLED: Explantation of native viscera in multivisceral transplant candidates, particularly in those with extensive portomesenteric thrombosis (PMT), carries considerable morbidity due to extensive vascularized adhesions. Preemptive visceral angioembol ... Full text Link to item Cite

Donor-Recipient Height Mismatch Is Associated With Decreased Survival in Pediatric-to-Adult Liver Transplant Recipients.

Journal Article Liver Transpl · February 2021 Liver grafts from pediatric donors represent a small fraction of grafts transplanted into adult recipients, and their use in adults requires special consideration of donor size to prevent perioperative complications. In the past, graft weight or volume rat ... Full text Link to item Cite

Preoperative carfilzomib and lulizumab based desensitization prolongs graft survival in a sensitized non-human primate model.

Journal Article Kidney Int · January 2021 Sensitized patients are difficult to transplant due to pre-formed anti-donor immunity. We have previously reported successful desensitization using carfilzomib and belatacept in a non-human primate (NHP) model. Here we evaluated selective blockade of the c ... Full text Link to item Cite

Need for Pretransplant Midodrine Does Not Negatively Impact Simultaneous Liver-kidney Transplant Outcomes.

Journal Article Transplant Direct · January 2021 BACKGROUND: Midodrine is often needed pretransplant to improve hemodynamics in simultaneous liver-kidney transplant candidates. Previous research has shown that patients requiring midodrine before kidney transplant alone have increased posttransplant risk ... Full text Link to item Cite

Spontaneous Ureterocolic Fistula between Nonfunctioning Kidney Transplant Ureter and Colon in Setting of Diverticulitis.

Journal Article Case Rep Transplant · 2021 Ureterocolic fistula is a rare condition that most commonly occurs in the setting of diverticular disease. The development of a ureterocolic fistula following kidney transplantation is even rarer, with no prior cases in the literature to our knowledge. We ... Full text Link to item Cite

Immune Thrombocytopenia Associated with Hepatitis B Virus and Autoimmune Hepatitis and Recovery of Platelet Count following Liver Transplantation.

Journal Article Case Rep Transplant · 2021 Immune thrombocytopenia is a consumptive coagulopathy that can be either idiopathic or associated with infectious or autoimmune etiologies. Here, we present a case of immune thrombocytopenia in the setting of acute liver failure due to coexisting diagnoses ... Full text Link to item Cite

Impact of Allosensitization on Xenotransplantation

Conference AMERICAN JOURNAL OF TRANSPLANTATION · 2021 Cite

Kidney transplant recipients infected by COVID-19: Review of the initial published experience.

Journal Article Transpl Infect Dis · December 2020 There is an accumulating body of literature surrounding the impact of COVID-19 infection in solid organ transplant recipients. The aim of this review was to summarize the existing literature specifically in kidney transplant (KTx) recipients, with an empha ... Full text Link to item Cite

Using Hepatocellular Carcinoma Tumor Burden Score to Stratify Prognosis after Liver Transplantation.

Journal Article Cancers (Basel) · November 14, 2020 Liver transplantation (LT) remains a mainstay of treatment for hepatocellular carcinoma (HCC). Tumor factors such as size and number of tumors define eligibility for LT using the Milan criteria. The tumor burden score (TBS) incorporates both tumor number a ... Full text Link to item Cite

Decreased graft loss following implementation of the kidney allocation score (KAS).

Journal Article Am J Surg · November 2020 BACKGROUND: The Kidney Allocation System (KAS) was developed to improve equity and utility in organ allocation. We examine the effect of this change on kidney graft distribution and survival. METHODS: UNOS data was used to identify first-time adult recipie ... Full text Link to item Cite

Textbook Outcomes in Liver Transplantation.

Journal Article World J Surg · October 2020 BACKGROUND: Textbook outcome (TO) is an emerging concept within multiple surgical domains, which represents a novel effort to define a standardized, composite quality benchmark based on multiple postoperative endpoints that represent the ideal "textbook" h ... Full text Link to item Cite

Outcomes in Kidney Transplantation Between Veterans Affairs and Civilian Hospitals: Considerations in the Context of the MISSION Act.

Journal Article Ann Surg · September 1, 2020 OBJECTIVE: We sought to compare kidney transplantation outcomes between Veterans Affairs (VA) and non-VA transplant centers. SUMMARY BACKGROUND DATA: Transplant care at the VA has previously been scrutinized due to geographic and systematic barriers. The r ... Full text Link to item Cite

Sirtuin-1 expression and activity is diminished in aged liver grafts.

Journal Article Sci Rep · July 17, 2020 The cellular mechanisms underlying impaired function of aged liver grafts have not been fully elucidated, but mitochondrial dysfunction appears to be contributory. Sirtuin1 has been identified as a key mediator of mitochondrial recovery following ischemia- ... Full text Link to item Cite

Transplant Outcomes in Older Patients With Nonalcoholic Steatohepatitis Compared to Alcohol-related Liver Disease and Hepatitis C.

Journal Article Transplantation · June 2020 BACKGROUND: Patients with nonalcoholic steatohepatitis (NASH) are waitlisted at older ages than individuals with other liver diseases, but the effect of age on liver transplantation (LT) outcomes in this population and whether it differs from other etiolog ... Full text Link to item Cite

Donor Leukocyte Trafficking and Damage-associated Molecular Pattern Expression During Ex Vivo Lung Perfusion.

Journal Article Transplant Direct · March 2020 BACKGROUND: While ex vivo lung perfusion (EVLP) has become established in lung transplantation, the cellular processes occurring during this period are not yet fully understood. Prior studies demonstrated that donor leukocytes (DLs) migrate from the graft ... Full text Open Access Link to item Cite

Type of Organ Transplanted Impacts the Risk and Presentation of Cutaneous Squamous Cell Carcinoma in Transplant Recipients.

Journal Article Exp Clin Transplant · February 2020 OBJECTIVES: Transplant immunosuppression increases the risk of cutaneous squamous cell carcinoma by 65- to 200-fold. Our objective was to investigate the impact of the type of organ transplanted on the risk and presentation of cutaneous squamous cell carci ... Full text Link to item Cite

Definition and Evaluation of Textbook Outcomes in Liver Transplantation

Conference AMERICAN JOURNAL OF TRANSPLANTATION · January 1, 2020 Link to item Cite

The Systemic Immune-Inflammation Index Predicts Clinical Outcomes in Kidney Transplant Recipients.

Journal Article In Vivo · 2020 BACKGROUND: Outcomes after kidney transplantation (KTx) remain limited by delayed graft function (DGF) and acute rejection. Non-invasive biomarkers may help identify patients at increased risk for these events. We examined the association between the syste ... Full text Link to item Cite

Increased Graft Survival Following Implementation of the Kidney Allocation Score

Conference AMERICAN JOURNAL OF TRANSPLANTATION · 2020 Cite

The surgical and immunosuppressive basis for infections in the pediatric solid organ transplant recipient

Chapter · January 1, 2020 Pediatric solid organ transplant changes the lives of thousands of patients every year. Balanced immunosuppression is essential in ensuring acceptance of the organ transplant and successful outcomes. The purpose of immunosuppression is to modulate the immu ... Full text Cite

Elderly Donors in Transplantation

Chapter · January 1, 2020 The disparity between supply and demand of donor organs remains a major limitation in the field of transplantation. Increased utilization of organs from older donors has significant potential to expand the pool of donor organs; however, utilization of such ... Full text Cite

Pretransplant Desensitization with Costimulation Blockade and Proteasome Inhibitor Reduces DSA and Delays Antibody-Mediated Rejection in Highly Sensitized Nonhuman Primate Kidney Transplant Recipients.

Journal Article J Am Soc Nephrol · December 2019 BACKGROUND: Patients with broad HLA sensitization have poor access to donor organs, high mortality while waiting for kidney transplant, and inferior graft survival. Although desensitization strategies permit transplantation via lowering of donor-specific a ... Full text Link to item Cite

Kidney Donor Profile Index Is a Reliable Alternative to Liver Donor Risk Index in Quantifying Graft Quality in Liver Transplantation.

Journal Article Transplant Direct · December 2019 BACKGROUND: The most established metric for estimating graft survival from donor characteristics in liver transplantation is the liver donor risk index (LDRI). The LDRI is calculated from donor and transplant-related variables, including cold ischemic time ... Full text Open Access Link to item Cite

Elevated Donor Hemoglobin A1C Impairs Kidney Graft Survival From Deceased Donors With Diabetes Mellitus: A National Analysis.

Journal Article Exp Clin Transplant · October 2019 OBJECTIVES: Kidney transplant is the optimal therapy for patients with end-stage renal disease. The presence of donor diabetes mellitus is a recognized risk factor for impaired kidney graft survival and is incorporated into the Kidney Donor Profile Index. ... Full text Link to item Cite

Machine perfusion of donor kidneys may reduce graft rejection.

Journal Article Clin Transplant · October 2019 Recent evidence suggests that hypothermic machine perfusion of donor kidneys reduces delayed graft function (DGF). This study addresses the effect of machine perfusion (MP) on allograft rejection in the United States. We assembled a retrospective cohort of ... Full text Link to item Cite

Donor kidney volume measured by computed tomography is a strong predictor of recipient eGFR in living donor kidney transplantation.

Journal Article World J Urol · September 2019 PURPOSE: The effect of living donor kidney allograft size on recipient outcomes is not well understood. In this study, we sought to investigate the relationship between preoperatively measured donor kidney volume and recipient estimated glomerular filtrati ... Full text Link to item Cite

The effect of levofloxacin on the lung microbiota of laboratory rats.

Journal Article Exp Lung Res · September 2019 Aim: The aim of this study was to investigate the short-term effect of levofloxacin on the microbiota of healthy lungs. Material and methods: Male F344 rats received either no levofloxacin (n = 9), intravenous levofloxacin (n = 12), oral levofloxacin (n =  ... Full text Link to item Cite

Damage- and pathogen-associated molecular patterns play differential roles in late mortality after critical illness.

Journal Article JCI Insight · August 22, 2019 Multiple organ failure (MOF) is the leading cause of late mortality and morbidity in patients who are admitted to intensive care units (ICUs). However, there is an epidemiologic discrepancy in the mechanism of underlying immunologic derangement dependent o ... Full text Link to item Cite

Improvement in Liver Transplant Outcomes From Older Donors: A US National Analysis.

Journal Article Ann Surg · August 2019 OBJECTIVE: To investigate trends in long-term graft and patient outcomes following liver transplantation using grafts from donors ≥60 years old. SUMMARY BACKGROUND DATA: The scarcity of donor livers has led to increased utilization of organs from donors ≥6 ... Full text Link to item Cite

Secondary lymphoid tissue and costimulation-blockade resistant rejection: A nonhuman primate renal transplant study.

Journal Article Am J Transplant · August 2019 Naïve T cell activation requires antigen presentation combined with costimulation through CD28, both of which optimally occur in secondary lymphoid tissues such as lymph nodes and the spleen. Belatacept impairs CD28 costimulation by binding its ligands, CD ... Full text Link to item Cite

Circulating mitochondria in organ donors promote allograft rejection.

Journal Article Am J Transplant · July 2019 The innate immune system is a critical regulator of the adaptive immune responses that lead to allograft rejection. It is increasingly recognized that endogenous molecules released from tissue injury and cell death are potent activators of innate immunity. ... Full text Link to item Cite

Machine Perfusion of Liver Grafts With Implantable Oxygen Biosensors: Proof of Concept Study in a Rodent Model.

Journal Article Transplant Direct · July 2019 BACKGROUND: Normothermic machine perfusion (NMP) is emerging as a novel preservation strategy in liver transplantation, but the optimal methods for assessing liver grafts during this period have not been determined. The aim of this study was to investigate ... Full text Link to item Cite

Damage-Associated Molecular Patterns Induce Inflammatory Injury During Machine Preservation of the Liver: Potential Targets to Enhance a Promising Technology.

Journal Article Liver Transpl · April 2019 Machine preservation (MP) has emerged as a promising technology in liver transplantation, but the cellular processes occurring during MP have not been characterized. Recent studies have noted the presence of inflammatory molecules generated during MP. We h ... Full text Link to item Cite

Living donor liver transplantation.

Journal Article Curr Opin Organ Transplant · April 2019 PURPOSE OF REVIEW: As experience grows, living donor liver transplantation (LDLT) has become an effective treatment option to overcome the deceased donor organ shortage. RECENT FINDINGS: Donor safety is the highest priority in LDLT. Strict donor selection ... Full text Link to item Cite

Early Immune Response to Acute Gastric Fluid Aspiration in a Rat Model of Lung Transplantation.

Journal Article Exp Clin Transplant · February 2019 OBJECTIVES: Chronic aspiration of gastric fluid contents can decrease long-term survival of pulmonary transplants due to development of obliterative bronchiolitis. However, little is known about the early immune response and the cascade of events involved ... Full text Link to item Cite

Donor derived HSV hepatitis in a kidney transplant recipient leading to liver fibrosis and portal hypertension.

Journal Article Transpl Infect Dis · February 2019 The unexpected transmission of donor-derived infection through organ transplantation is a rare event with current donor screening practices. In this case report we describe a probable donor-derived transmission of Herpes Simplex Virus (HSV)-2 via deceased ... Full text Link to item Cite

Renal outcomes following left renal vein harvest for venous reconstruction during pancreas and liver surgery.

Journal Article HPB (Oxford) · January 2019 BACKGROUND: The left renal vein (LRV) may be used for venous reconstruction during hepato-pancreato-biliary (HPB) surgery, although concerns exist about compromising renal function. This study aimed to determine renal outcomes following LRV harvest during ... Full text Link to item Cite

Simultaneous Versus Sequential Heart-liver Transplantation: Ideal Strategies for Organ Allocation.

Journal Article Transplant Direct · January 2019 BACKGROUND: Simultaneous heart-liver (SHL) transplantation is an efficacious therapeutic modality for patients with combined heart and liver failure. However, the extent to which heart transplantation followed by sequential liver transplantation (LAH) can ... Full text Link to item Cite

DAMP Release and Inflammasome Activation during Machine Preservation of the Liver

Conference AMERICAN JOURNAL OF TRANSPLANTATION · January 1, 2019 Link to item Cite

Comparison between liver transplantation and resection for hilar cholangiocarcinoma: A systematic review and meta-analysis.

Journal Article PLoS One · 2019 BACKGROUND: Hilar cholangiocarcinoma (hCCA) is a rare and aggressive malignancy with R0 resection being currently the only option for long-term survival. With the improvement in the outcomes of liver transplantation (LT), the indications for LT have expand ... Full text Link to item Cite

Extracellular Mitochondrial DNA and N-Formyl Peptides in Trauma and Critical Illness: A Systematic Review.

Journal Article Crit Care Med · December 2018 OBJECTIVES: Extracellular mitochondrial DNA and N-formyl peptides released following tissue damage may contribute to systemic inflammation through stimulation of the innate immune system. In this review, we evaluate existing in vivo human data regarding a ... Full text Link to item Cite

Improved contemporary outcomes of liver transplantation for pediatric hepatoblastoma and hepatocellular carcinoma.

Journal Article Pediatr Transplant · December 2018 PURPOSE: Improvement in outcomes of LT for pediatric HB and HCC has been reported in small series. We analyzed national outcomes and changes in donor, recipient, and perioperative factors over time that may contribute to survival differences. METHODS: The ... Full text Link to item Cite

Mitochondria Released by Apoptotic Cell Death Initiate Innate Immune Responses.

Journal Article Immunohorizons · December 2018 In solid organ transplantation, cell death arising from ischemia/reperfusion leads to the release of several damage-associated molecular patterns derived from mitochondria. Mitochondrial damage-associated molecular patterns (mtDAMPs) initiate proinflammato ... Full text Link to item Cite

Outcomes of patients with a pretransplant history of early-stage melanoma.

Journal Article Melanoma Res · October 2018 A history of melanoma within the preceding 5 years is commonly considered a contraindication to solid organ transplantation. We investigated how a pretransplant history of melanoma impacts patient survival and melanoma recurrence. Institutional Review Boar ... Full text Link to item Cite

Live donor liver transplantation with older donors: Increased long-term graft loss due to HCV recurrence.

Journal Article Clin Transplant · August 2018 Using our prospectively collected database all adult hepatitis C virus (HCV)-positive patients receiving an adult-to-adult LDLT between October 2000 and May 2014 were identified. Outcome of LDLT with grafts from younger (<50 years=128) vs older donors (≥50 ... Full text Link to item Cite

The Volume-outcome Relationship in Deceased Donor Kidney Transplantation and Implications for Regionalization.

Journal Article Ann Surg · June 2018 OBJECTIVE: The aim of this study was to investigate the volume-outcome relationship in kidney transplantation by examining graft and patient outcomes using standardized risk adjustment (observed-to-expected outcomes). A secondary objective was to examine t ... Full text Link to item Cite

CXCR4 Inhibition Improves Donor Leukocyte Depletion during Ex Vivo Lung Perfusion.

Conference AMERICAN JOURNAL OF TRANSPLANTATION · June 1, 2018 Link to item Cite

Single-Center Long-Term Analysis of Combined Liver-Lung Transplant Outcomes.

Journal Article Transplant Direct · May 2018 BACKGROUND: Combined lung-liver transplantation (LLT) applies 2 technically challenging transplants in 1 patient with severe 2-organ failure. METHODS: Institutional medical records and United Network for Organ Sharing database were queried for patients at ... Full text Open Access Link to item Cite

Liver Transplantation Without Venovenous Bypass: Does Surgical Approach Matter?

Journal Article Transplant Direct · May 2018 BACKGROUND: The use of venovenous bypass in liver transplantation has declined over time. Few studies have examined the impact of surgical approach in cases performed exclusively without venovenous bypass. We hypothesized that advances in liver transplant ... Full text Link to item Cite

Accessory Gallbladder Complicating Liver Transplantation.

Journal Article Transplant Direct · May 2018 Accessory gallbladder in a donor liver allograft is an uncommon anatomical finding that can complicate liver transplantation if unrecognized. This case describes a patient who underwent liver transplantation with a donor graft containing an accessory gallb ... Full text Link to item Cite

Flap repair of complex pilonidal sinus: a single institution experience

Journal Article European Journal of Plastic Surgery · April 1, 2018 Background: Healing of pilonidal cysts after initial excision remains a vexing problem for surgeons. While simple sinus can be managed with success, recurrence of the cyst after primary excision or sizeable sinus often requires a more complex repair; howev ... Full text Cite

CXCR4 Inhibition Improves Donor Leukocyte Depletion During Ex Vivo Lung Perfusion

Conference The Journal of Heart and Lung Transplantation · April 2018 Full text Cite

Combined lung-liver-pancreas transplantation in a recipient with cystic fibrosis.

Journal Article J Cyst Fibros · January 2018 Cystic fibrosis (CF) affects multiple organs including the lung, liver, and pancreas. Lung transplant, liver transplant, and combined lung-liver transplant have become well-established therapies for CF patients with end-stage organ failure. Thus far, howev ... Full text Link to item Cite

Immunothrombotic Activity of Damage-Associated Molecular Patterns and Extracellular Vesicles in Secondary Organ Failure Induced by Trauma and Sterile Insults.

Journal Article Front Immunol · 2018 Despite significant improvements in injury prevention and emergency response, injury-related death and morbidity continues to increase in the US and worldwide. Patients with trauma, invasive operations, anti-cancer treatment, and organ transplantation prod ... Full text Link to item Cite

Heparan sulfate is a plasma biomarker of acute cellular allograft rejection.

Journal Article PLoS One · 2018 Despite advances in management of immunosuppression, graft rejection remains a significant clinical problem in solid organ transplantation. Non-invasive biomarkers of graft rejection can facilitate earlier diagnosis and treatment of acute rejection. The pu ... Full text Link to item Cite

Effect of gastric fluid aspiration on the lung microbiota of laboratory rats.

Journal Article Exp Lung Res · 2018 AIM OF THE STUDY: The pulmonary microbiota is important for both normal homeostasis and the progression of disease, and may be affected by aspiration of gastric fluid. The aim of this study was to investigate changes in the lung microbiota induced by aspir ... Full text Link to item Cite

Neuroendocrine carcinomas of the gallbladder: Lessons learnt from cases at opposite ends of the spectrum.

Journal Article J BUON · 2018 Neuroendocrine tumors are the rarest tumors of gallbladder. The most aggressive variant is neuroendocrine carcinoma which represents about 0.5% of all gallbladder carcinomas and 0.2% of all neuroendocrine tumors. It seems possible that survival rates can b ... Link to item Cite

Characteristics of liver transplant candidates delisted following recompensation and predictors of such delisting in alcohol-related liver disease: a case-control study.

Journal Article Transpl Int · November 2017 Whether and when recovery beyond the need for transplant may occur in patients listed for decompensation remains unclear. This study aimed to investigate the characteristics of patients delisted following recompensation. Seventy-seven patients who were lis ... Full text Link to item Cite

Elevated HbA1c in donor organs from patients without a diagnosis of diabetes portends worse liver allograft survival.

Journal Article Clin Transplant · September 2017 Recipients of liver allografts from diabetic donors have decreased graft survival. However, limited data exist on the effects of donor HbA1c. We hypothesized that allografts from nondiabetic donors with elevated HbA1c would be associated with decreased sur ... Full text Link to item Cite

Pancreas Transplantation With Portal-Enteric Drainage for Patients With Endocrine and Exocrine Insufficiency From Extensive Pancreatic Resection.

Journal Article Transplantation direct · September 2017 Although the primary indication for pancreas transplantation is type I diabetes, a small number of patients requires pancreas transplantation to manage combined endocrine and exocrine insufficiency that develops after extensive native pancreatic resection. ... Full text Cite

Early Intervention With Live Donor Liver Transplantation Reduces Resource Utilization in NASH: The Toronto Experience.

Journal Article Transplant Direct · June 2017 BACKGROUND: In parallel with the obesity epidemic, liver transplantation for nonalcoholic steatohepatitis (NASH) is increasing dramatically in North America. Although survival outcomes are similar to other etiologies, liver transplantation in the NASH popu ... Full text Link to item Cite

Painful Groin Mass in a Liver Transplant Recipient.

Journal Article Am J Transplant · February 2017 Full text Link to item Cite

Murine model of oropharyngeal gastric fluid aspiration-A new assessment method for intrapulmonary liquid distribution using digital pixel calculation.

Journal Article Exp Lung Res · 2017 AIM OF THE STUDY: The aim of this study was to investigate a new method for visualization and quantification of intrapulmonary liquid distribution after oropharyngeal gastric fluid aspiration in mice. MATERIAL AND METHODS: Eleven mice received oropharyngea ... Full text Link to item Cite

The extended Toronto criteria for liver transplantation in patients with hepatocellular carcinoma: A prospective validation study.

Journal Article Hepatology · December 2016 UNLABELLED: The selection of liver transplant candidates with hepatocellular carcinoma (HCC) relies mostly on tumor size and number. Instead of relying on these factors, we used poor tumor differentiation and cancer-related symptoms to exclude patients lik ... Full text Link to item Cite

Anti-inflammatory signaling during ex vivo liver perfusion improves the preservation of pig liver grafts before transplantation.

Journal Article Liver Transpl · November 2016 Normothermic ex vivo liver perfusion (NEVLP) improves graft preservation by avoiding cold ischemia injury. We investigated whether the protective effects of NEVLP can be further improved by applying strategies targeted on reducing the activation of proinfl ... Full text Link to item Cite

CT volumetry is superior to nuclear renography for prediction of residual kidney function in living donors.

Journal Article Clin Transplant · September 2016 Living kidney donor evaluation commonly includes nuclear renography to assess split kidney function and computed tomography (CT) scan to evaluate anatomy. To streamline donor workup and minimize exposure to radioisotopes, we sought to assess the feasibilit ... Full text Link to item Cite

Ex-vivo liver perfusion for organ preservation: Recent advances in the field.

Journal Article Transplant Rev (Orlando) · July 2016 Liver transplantation is the optimal treatment for end-stage liver disease but is limited by the severe shortage of donor organs. This shortage has prompted increased utilization of marginal grafts from DCD and extended criteria donors, which poorly tolera ... Full text Link to item Cite

Normothermic and subnormothermic ex-vivo liver perfusion in liver transplantation.

Journal Article Curr Opin Organ Transplant · June 2016 PURPOSE OF REVIEW: In the current era of extreme organ shortage, warm (subnormothermic and normothermic) ex-vivo liver perfusion has emerged as a novel strategy to recover marginal organs and increase the organ pool. Over the last decade, significant progr ... Full text Link to item Cite

Caval Replacement versus Piggyback Liver Transplantation: The Toronto Experience.

Conference AMERICAN JOURNAL OF TRANSPLANTATION · June 1, 2016 Link to item Cite

Live Donor Liver Transplantation for NASH: The Toronto Experience.

Conference AMERICAN JOURNAL OF TRANSPLANTATION · June 1, 2016 Link to item Cite

Duodenal Graft Complications After Pancreas Transplant: Evolving Management.

Conference AMERICAN JOURNAL OF TRANSPLANTATION · June 1, 2016 Link to item Cite

The significance of pre-operative coronary interventions on outcome after pancreas transplantation.

Journal Article Clin Transplant · March 2016 Pancreas transplant candidates are at very high risk of coronary vascular disease. We hypothesized that the requirement for pre-operative coronary intervention (PCI) may be associated with an adverse impact on short- and long-term outcomes. Retrospective a ... Full text Link to item Cite

Review of complications associated with endoscopic pancreatic cyst-gastrostomy: a single-institution experience.

Journal Article Surg Laparosc Endosc Percutan Tech · June 2015 BACKGROUND: Pancreatic fluid collections can form after episodes of pancreatitis, either acute or chronic. The majority will resolve spontaneously but when decompression is mandated, endoscopic drainage is the method of choice. However, it is not void of c ... Full text Link to item Cite

Duodenal Stump Blowout

Chapter · April 27, 2015 This book provides a comprehensive, state-of-the art, definitive reference for the diagnosis and management of difficult-to-manage complications following advanced gastrointestinal surgery. ... Cite

Hepatic and pancreatic resection in patients with end-stage renal disease: a propensity analysis.

Journal Article HPB (Oxford) · November 2014 BACKGROUND: Hepatic and pancreatic surgery is rarely performed in patients with end-stage renal disease (ESRD). The present authors used a national clinical database to characterize outcomes and perioperative risk in ESRD patients who require hepatic or pa ... Full text Link to item Cite

Open versus endovascular repair of ruptured abdominal aortic aneurysms.

Journal Article Ann Vasc Surg · July 2014 BACKGROUND: Management of ruptured abdominal aortic aneurysms (rAAA) remains one of the most challenging situations in vascular surgery. The aim of our study was to examine national trends and compare contemporary outcomes of open and endovascular repair ( ... Full text Link to item Cite

Does the presence of coronary artery disease impact perioperative outcomes following partial hepatectomy?

Journal Article J Gastrointest Surg · April 2014 INTRODUCTION: Coronary artery disease (CAD) is often considered a contraindication to hepatectomy despite a lack of data to support this practice. The purpose of this study is to evaluate the impact of CAD on postoperative outcomes in patients undergoing h ... Full text Link to item Cite

Liver transplantation in an adolescent with acute liver failure from acute lymphoblastic leukemia.

Journal Article Pediatr Transplant · March 2014 The most common identifiable causes of acute liver failure in pediatric patients are infection, drug toxicity, metabolic disease, and autoimmune processes. In many cases, the etiology of acute liver failure cannot be determined. Acute leukemia is an extrem ... Full text Link to item Cite

Development and implementation of a formalized geriatric surgery curriculum for general surgery residents.

Journal Article Gerontol Geriatr Educ · 2014 Despite the growth of the elderly population, most surgical training programs lack formalized geriatric education. The authors' aim was to implement a formalized geriatric surgery curriculum at an academic medical center. Surgery residents were surveyed on ... Full text Link to item Cite

Structural insights into Notch1 ligands - protein targets in breast cancer

Conference EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS · July 1, 2013 Link to item Cite

Pediatric injury patterns by year of age.

Journal Article J Pediatr Surg · June 2013 PURPOSE: Since trauma is the leading cause of death and disability among children, understanding injury patterns may reduce morbidity and mortality through targeted prevention efforts. The purpose of this study was to identify pediatric injury patterns by ... Full text Link to item Cite

Examining reoperation and readmission after hepatic surgery.

Journal Article J Am Coll Surg · May 2013 BACKGROUND: Although the perioperative mortality from hepatic resection has improved considerably, this procedure is still associated with substantial morbidity and resource use. The goal of this investigation was to characterize the incidence, patterns, a ... Full text Link to item Cite

Impact of Recipient BMI: Implications for ECD Renal Transplantation.

Conference AMERICAN JOURNAL OF TRANSPLANTATION · April 1, 2013 Link to item Cite

Outcomes of Simultaneous Liver-Kidney Transplantation from DCD Organ Donors

Conference AMERICAN JOURNAL OF TRANSPLANTATION · April 1, 2013 Link to item Cite

A 10-year longitudinal analysis of surgical management for acute ischemic colitis.

Journal Article J Gastrointest Surg · April 2013 INTRODUCTION: Our objective was to review our 10-year experience of surgical resection for acute ischemic colitis (IC) and to assess the predictive value of previously reported risk-stratification methods. METHODS: We retrospectively reviewed all adult pat ... Full text Link to item Cite

Trends in Usage and Outcomes for Expanded Criteria Donor Kidney Transplantation.

Conference AMERICAN JOURNAL OF TRANSPLANTATION · April 1, 2013 Link to item Cite

Posterior reversible encephalopathy syndrome independently associated with tacrolimus and sirolimus after multivisceral transplantation.

Journal Article Am J Transplant · March 2013 Posterior reversible encephalopathy syndrome (PRES) is a small vessel microangiopathy of the cerebral vasculature that occurs in 0.5-5% of solid organ transplant recipients, most commonly associated with tacrolimus (Tac). Clinical manifestations include hy ... Full text Link to item Cite

Primary hepatic malignancies

Chapter · January 1, 2013 Full text Cite

Laparoscopic versus open Hartmann procedure for the emergency treatment of diverticulitis: a propensity-matched analysis.

Journal Article Dis Colon Rectum · January 2013 BACKGROUND: A laparoscopic approach has been proposed to reduce the high morbidity and mortality associated with the Hartmann procedure for the emergency treatment of diverticulitis. OBJECTIVE: The objective of our study was to determine whether a laparosc ... Full text Link to item Cite

The impact of portal vein resection on outcomes for hilar cholangiocarcinoma: a multi-institutional analysis of 305 cases.

Journal Article Cancer · October 1, 2012 UNLABELLED: BACKGROUND. Surgical strategy for hilar cholangiocarcinoma often includes hepatectomy, but the role of portal vein resection (PVR) remains controversial. In this study, the authors sought to identify factors associated with outcome after surgic ... Full text Link to item Cite

Effect of surgeon specialization on long-term survival following colon cancer resection at an NCI-designated cancer center.

Journal Article J Surg Oncol · September 1, 2012 BACKGROUND: Recent studies have documented improved outcomes for patients undergoing colorectal cancer resection at NCI cancer centers compared to hospitals without this designation. Proposed contributory factors include a higher proportion of surgeons wit ... Full text Link to item Cite

Impact of simultaneous diaphragm resection during hepatectomy for treatment of metastatic colorectal cancer.

Journal Article J Gastrointest Surg · August 2012 INTRODUCTION: For colorectal cancer patients with liver metastases involving the hepatic dome or invading the diaphragm, a concomitant diaphragm resection is often required to achieve negative surgical margins. The purpose of this study is to determine whe ... Full text Link to item Cite

Hepatic resection for metastatic gastrointestinal stromal tumors in the tyrosine kinase inhibitor era.

Journal Article Cancer · July 15, 2012 BACKGROUND: Before the advent of tyrosine kinase inhibitors (TKIs), surgical resection was the primary treatment for hepatic gastrointestinal stromal tumor (GIST) metastases. Although TKIs have improved survival in the metastatic setting, outcomes after mu ... Full text Link to item Cite

Vascular surgery collaboration during pancreaticoduodenectomy with vascular reconstruction.

Journal Article Ann Vasc Surg · July 2012 BACKGROUND: Once thought to have unresectable disease, pancreatic cancer patients with portal venous involvement are now reported to have comparable survival after pancreaticoduodenectomy (PD) with vascular reconstruction (VR) as compared with patients wit ... Full text Link to item Cite

Comparison of outcomes and the use of multimodality therapy in young and elderly people undergoing surgical resection of pancreatic cancer.

Journal Article J Am Geriatr Soc · February 2012 OBJECTIVES: To compare outcomes and the use of multimodality therapy in young and elderly people with pancreatic cancer undergoing surgical resection. DESIGN: Retrospective, single-institution study. SETTING: National Cancer Institute/National Comprehensiv ... Full text Link to item Cite

Post-operative pharmacologic thromboprophylaxis after major hepatectomy: does peripheral venous thromboembolism prevention outweigh bleeding risks?

Journal Article J Gastrointest Surg · September 2011 BACKGROUND: Although standard of care after most abdominal surgeries, post-operative pharmacologic thromboprophylaxis after major hepatectomy is commonly withheld due to bleeding risks. The objective of this retrospective study is to evaluate the benefits ... Full text Link to item Cite

Advanced fellowship training is associated with improved lymph node retrieval in colon cancer resections.

Journal Article J Surg Res · September 2011 BACKGROUND: Examination of at least 12 lymph nodes has been established as the standard of care for adequate staging of colon cancer. The purpose of this study was to determine whether surgeon fellowship training, patient body mass index (BMI), and surgica ... Full text Link to item Cite

Recent advances in immunosuppressive therapy for prevention of renal allograft rejection.

Journal Article Curr Opin Organ Transplant · August 2011 PURPOSE OF REVIEW: Current immunosuppressive therapies are highly successful at regulating acute allograft rejection and inducing long-term transplanted kidney survival; however, currently available medications are associated with generalized immune suppre ... Full text Link to item Cite

A standard definition of major hepatectomy: resection of four or more liver segments.

Journal Article HPB (Oxford) · July 2011 BACKGROUND: While commonly used to describe liver resections at risk for post-operative complications, no standard definition of 'major hepatectomy' exists. The objective of the present retrospective study is to specify the extent of hepatic resection that ... Full text Link to item Cite

Major liver resection in elderly patients: a multi-institutional analysis.

Journal Article J Am Coll Surg · May 2011 BACKGROUND: Because of the aging United States population, increase in overall life expectancy, and rising incidence of hepatobiliary tumors, more elderly patients are considered for hepatic resection. The objective of this study was to assess the influenc ... Full text Link to item Cite

Incorporation of secretory immunoglobulin A into biofilms can decrease their resistance to ciprofloxacin.

Journal Article Microbiol Immunol · March 2011 Extracellular matrices utilized by biofilms growing on inert surfaces are generally produced entirely by the bacteria growing within those biofilms, whereas symbiotic (mutualistic) biofilms growing in or on a wide range of plants and animals utilize host-d ... Full text Link to item Cite

Coagulopathy in α-galactosyl transferase knockout pulmonary xenotransplants.

Journal Article Xenotransplantation · 2011 BACKGROUND: After substantial progress on many fronts, one of the remaining barriers still opposing the clinical application of xenotransplantation is a disseminated intravascular coagulopathy (DIC) that is observed in the pre-clinical model of porcine-to- ... Full text Link to item Cite

Safety of hepatic resection in aged patients: a retrospective, multi-institutional analysis

Conference Journal of the American College of Surgeons · September 2010 Full text Cite

Aptamer applications for targeted cancer therapy.

Journal Article Future Oncol · July 2010 Aptamers are single-stranded DNA or RNA oligonucleotides that assume specific 3D structures and bind to target molecules with high affinity. The unique specificity of aptamers has made them attractive agents for targeted cancer therapy. Aptamers have been ... Full text Link to item Cite

Peri-operative outcomes of pancreaticoduodenectomy in the elderly.

Conference JOURNAL OF THE AMERICAN GERIATRICS SOCIETY · April 1, 2010 Link to item Cite

Altering and assessing persistence of genetically modified E. coli MG1655 in the large bowel.

Journal Article Exp Biol Med (Maywood) · October 2009 One of the primary factors limiting the efficacy of probiotic therapies is short persistence time. Utilizing a novel method for assessment of persistence in the large bowel independent of survival of the organisms in the upper GI tract, we tested whether o ... Full text Link to item Cite

Synchronous colorectal liver metastases: is it time to reconsider traditional paradigms of management?

Journal Article Ann Surg Oncol · September 2009 BACKGROUND: Patients with synchronous colorectal liver metastases (CLM) are typically treated with initial colorectal resection followed by arbitrary and prolonged courses of chemotherapy. Partial hepatectomy is considered only for patients without interva ... Full text Link to item Cite

Timing of multimodality therapy for resectable synchronous colorectal liver metastases: a retrospective multi-institutional analysis.

Journal Article Ann Surg Oncol · July 2009 The optimal timing of chemotherapy relative to resection of synchronous colorectal liver metastases (SCRLM) is not known. The objective of this retrospective multi-institutional study was to assess the influence of chemotherapy administered before and afte ... Full text Link to item Cite

The development and testing of aptamers for cancer.

Journal Article Curr Opin Investig Drugs · June 2009 Aptamers are single-stranded DNA or RNA oligonucleotides that have specific three-dimensional structures and bind to target molecules. Several unique properties of aptamers, including high binding specificity, low immunogenicity, structural stability and e ... Link to item Cite

Multiagent chemotherapy for isolated colorectal liver metastases: a single-centered retrospective study.

Journal Article J Gastrointest Surg · January 2009 BACKGROUND: Few studies identifying variables associated with prognosis after resection of colorectal liver metastases (CLM) account for treatment with multiagent chemotherapy (fluoropyrmidines with irinotecan, oxaliplatin, bevacizumab, and/or cetuximab). ... Full text Link to item Cite

Hepatic parenchymal transection with vascular staplers: a comparative analysis with the crush-clamp technique.

Journal Article Am J Surg · November 2008 BACKGROUND: This retrospective study compares the safety and efficacy of hepatic parenchymal transection using vascular staplers (VS) and the crush-clamp (CC) technique. METHODS: Demographics, clinicopathologic data, treatments, and postoperative outcomes ... Full text Link to item Cite

Chronic aspiration shifts the immune response from Th1 to Th2 in a murine model of asthma.

Journal Article Eur J Clin Invest · August 2008 BACKGROUND: Chronic aspiration associated with gastro oesophageal reflux disease (GERD) is thought to play a substantial role in the development of asthma, the incidence of which is dramatically increasing in industrially developed countries. The majority ... Full text Link to item Cite

Biofilms in the large bowel suggest an apparent function of the human vermiform appendix.

Journal Article J Theor Biol · December 21, 2007 The human vermiform ("worm-like") appendix is a 5-10cm long and 0.5-1cm wide pouch that extends from the cecum of the large bowel. The architecture of the human appendix is unique among mammals, and few mammals other than humans have an appendix at all. Th ... Full text Link to item Cite

Simultaneous resections of colorectal cancer and synchronous liver metastases: a multi-institutional analysis.

Journal Article Ann Surg Oncol · December 2007 BACKGROUND: The safety of simultaneous resections of colorectal cancer and synchronous liver metastases (SCRLM) is not established. This multi-institutional retrospective study compared postoperative outcomes after simultaneous and staged colorectal and he ... Full text Link to item Cite

Resection of noncolorectal nonneuroendocrine liver metastases: a comparative analysis.

Journal Article J Am Coll Surg · March 2007 BACKGROUND: Although established for metastatic colorectal (CR) and neuroendocrine (NE) malignancies, the role of partial hepatectomy in management of metastases from other primaries (NCRNE) is not well-defined. STUDY DESIGN: The objective of this retrospe ... Full text Link to item Cite