Scholars@Duke
Ellen Ruth Bennett

Ellen Ruth Bennett

Adjunct Assistant Professor in the Department of Neurology
Neurology, Neurocritical Care
benne020@mc.duke.edu
Duke Box 2900, Durham, NC 27710
Bryan Research Bldg, Durham, NC 27710

Selected Publications

A Randomized, Placebo-Controlled, Phase II Trial of Intravenous Allogeneic Non-HLA Matched, Unrelated Donor, Cord Blood Infusion for Ischemic Stroke.

Journal Article Stem Cells Transl Med · February 14, 2024 Stroke remains a leading cause of death and disability in the US, and time-limited reperfusion strategies remain the only approved treatment options. To address this unmet clinical need, we conducted a phase II randomized clinical trial to determine whethe ... Full text Open Access Link to item Cite

Postoperative changes in cognition and cerebrospinal fluid neurodegenerative disease biomarkers.

Journal Article Ann Clin Transl Neurol · February 2022 OBJECTIVE: Numerous investigators have theorized that postoperative changes in Alzheimer's disease neuropathology may underlie postoperative neurocognitive disorders. Thus, we determined the relationship between postoperative changes in cognition and cereb ... Full text Open Access Link to item Cite

Perioperative neurocognitive and functional neuroimaging trajectories in older APOE4 carriers compared with non-carriers: secondary analysis of a prospective cohort study.

Journal Article Br J Anaesth · December 2021 BACKGROUND: Cognitive dysfunction after surgery is a major issue in older adults. Here, we determined the effect of APOE4 on perioperative neurocognitive function in older patients. METHODS: We enrolled 140 English-speaking patients ≥60 yr old scheduled fo ... Full text Open Access Link to item Cite

Cerebrospinal Fluid Proteome Changes in Older Non-Cardiac Surgical Patients with Postoperative Cognitive Dysfunction.

Journal Article J Alzheimers Dis · 2021 BACKGROUND: Postoperative cognitive dysfunction (POCD), a syndrome of cognitive deficits occurring 1-12 months after surgery primarily in older patients, is associated with poor postoperative outcomes. POCD is hypothesized to result from neuroinflammation; ... Full text Open Access Link to item Cite

Intravenous Lidocaine Does Not Improve Neurologic Outcomes after Cardiac Surgery: A Randomized Controlled Trial.

Journal Article Anesthesiology · June 2019 BACKGROUND: Cognitive decline after cardiac surgery occurs frequently and persists in a significant proportion of patients. Preclinical studies and human trials suggest that intravenous lidocaine may confer protection in the setting of neurologic injury. I ... Full text Open Access Link to item Cite

Haptoglobin genotype and aneurysmal subarachnoid hemorrhage: Individual patient data analysis.

Journal Article Neurology · April 30, 2019 OBJECTIVE: To perform an individual patient-level data (IPLD) analysis and to determine the relationship between haptoglobin (HP) genotype and outcomes after aneurysmal subarachnoid hemorrhage (aSAH). METHODS: The primary outcome was favorable outcome on t ... Full text Open Access Link to item Cite

Sex Differences in Gene and Protein Expression After Intracerebral Hemorrhage in Mice.

Journal Article Transl Stroke Res · April 2019 Sex dimorphism has been demonstrated after experimental intracerebral hemorrhage (ICH). Decreased mortality and improved neurobehavioral outcomes occur in female compared to male mice after intrastriatal autologous blood or collagenase injection. Sex-speci ... Full text Link to item Cite

The Effect of the Relationship of APOE Polymorphisms and Cerebral Vasospasm on Functional Outcomes in Children With Traumatic Brain Injury.

Journal Article Biol Res Nurs · October 2018 BACKGROUND: Pediatric traumatic brain injury (TBI) is a leading cause of death and disability. Polymorphisms in the apolipoprotein E ( APOE) gene have been linked to cerebral vasospasm (CV) and poor outcomes in adults with TBI, yet these associations remai ... Full text Link to item Cite

Allogeneic Umbilical Cord Blood Infusion for Adults with Ischemic Stroke: Clinical Outcomes from a Phase I Safety Study.

Journal Article Stem Cells Transl Med · July 2018 Stroke is a major cause of death and long-term disability, affecting one in six people worldwide. The only currently available approved pharmacological treatment for ischemic stroke is tissue plasminogen activator; however, relatively few patients are elig ... Full text Open Access Link to item Cite

18F-florbetapir Positron Emission Tomography-determined Cerebral β-Amyloid Deposition and Neurocognitive Performance after Cardiac Surgery.

Journal Article Anesthesiology · April 2018 BACKGROUND: Amyloid deposition is a potential contributor to postoperative cognitive dysfunction. The authors hypothesized that 6-week global cortical amyloid burden, determined by F-florbetapir positron emission tomography, would be greater in those patie ... Full text Link to item Cite

Genetic polymorphisms associated with the risk of concussion in 1056 college athletes: a multicentre prospective cohort study.

Journal Article Br J Sports Med · February 2018 BACKGROUND/AIM: To evaluate the association of genetic polymorphisms APOE, APOE G-219T promoter, microtubule associated protein(MAPT)/tau exon 6 Ser53Pro, MAPT/tau Hist47Tyr, IL-6572 G/C and IL-6RAsp358Ala with the risk of concussion in college athletes. M ... Full text Link to item Cite

Association of IL6ST (gp130) Polymorphism with Functional Outcome Following Spontaneous Intracerebral Hemorrhage.

Journal Article J Stroke Cerebrovasc Dis · January 2018 BACKGROUND AND PURPOSE: Genes associated with the inflammatory response and cytostructural integrity may influence recovery following a brain injury. To examine this in the setting of spontaneous intracerebral hemorrhage (ICH), selected single nucleotide p ... Full text Link to item Cite

Multicenter cohort study on association of genotypes with prospective sports concussion: methods, lessons learned, and recommendations.

Journal Article J Sports Med Phys Fitness · 2017 BACKGROUND: Approximately 3.8 million sports related TBIs occur per year. Genetic variation may affect both TBI risk and post-TBI clinical outcome. Limited research has focused on genetic risk for concussion among athletes. We describe the design, methods, ... Full text Link to item Cite

A blood-based biomarker panel to risk-stratify mild traumatic brain injury.

Journal Article PLoS One · 2017 Mild traumatic brain injury (TBI) accounts for the vast majority of the nearly two million brain injuries suffered in the United States each year. Mild TBI is commonly classified as complicated (radiographic evidence of intracranial injury) or uncomplicate ... Full text Open Access Link to item Cite

The Effect of Propofol Versus Isoflurane Anesthesia on Human Cerebrospinal Fluid Markers of Alzheimer's Disease: Results of a Randomized Trial.

Journal Article J Alzheimers Dis · April 15, 2016 BACKGROUND: Preclinical studies have found differential effects of isoflurane and propofol on the Alzheimer's disease (AD)-associated markers tau, phosphorylated tau (p-tau) and amyloid-β (Aβ). OBJECTIVE: We asked whether isoflurane and propofol have diffe ... Full text Open Access Link to item Cite

Chapter 6 state of the science of pediatric traumatic brain injury: biomarkers and gene association studies.

Journal Article Annu Rev Nurs Res · 2015 OBJECTIVES: Our objective is to review the most widely used biomarkers and gene studies reported in pediatric traumatic brain injury (TBI) literature, to describe their findings, and to discuss the discoveries and gaps that advance the understanding of bra ... Full text Link to item Cite

Association of APOE and other genetic polymorphisms with prospective concussion risk in a prospective cohort study of college athletes

Conference Proceedings of the 2014 Biomedical Sciences and Engineering Conference - 5th Annual ORNL Biomedical Sciences and Engineering Conference: Collaborative Biomedical Innovations - The Multi-Scale Brain: Spanning Molecular, Cellular, Systems, Cognitive, Behavioral, and Clinical Neuroscience, BSEC 2014 · July 29, 2014 The management of sports concussion and an understanding of its risk factors are major foci i. The literature on athletic injury. Althoug. There is known influence of some genetic polymorphisms (GPs), such as APOE an. The APOE promoter, on traumatic brain ... Full text Cite

3-D transcranial ultrasound imaging with bilateral phase aberration correction of multiple isoplanatic patches: a pilot human study with microbubble contrast enhancement.

Journal Article Ultrasound Med Biol · January 2014 Featured Publication With stroke currently the second-leading cause of death globally, and 87% of all strokes classified as ischemic, the development of a fast, accessible, cost-effective approach for imaging occlusive stroke could have a significant impact on health care outc ... Full text Link to item Cite

Intraoperative magnesium administration does not improve neurocognitive function after cardiac surgery.

Journal Article Stroke · December 2013 BACKGROUND AND PURPOSE: Neurocognitive decline occurs frequently after cardiac surgery and persists in a significant number of patients. Magnesium is thought to provide neuroprotection by preservation of cellular energy metabolism, blockade of the N-methyl ... Full text Link to item Cite

Simultaneous bilateral real-time 3-d transcranial ultrasound imaging at 1 MHz through poor acoustic windows.

Journal Article Ultrasound Med Biol · April 2013 Featured Publication Ultrasound imaging has been proposed as a rapid, portable alternative imaging modality to examine stroke patients in pre-hospital or emergency room settings. However, in performing transcranial ultrasound examinations, 8%-29% of patients in a general popul ... Full text Link to item Cite

ApolipoproteinE mimetic peptides improve outcome after focal ischemia.

Journal Article Exp Neurol · March 2013 Featured Publication Growing clinical evidence implicates isoform-specific effects of apolipoprotein E (apoE) in reducing neuroinflammation and mediating adaptive responses following ischemic and traumatic brain injury. However, the intact apoE holoprotein does not cross the b ... Full text Link to item Cite

Utility of a simple algorithm to grade diastolic dysfunction and predict outcome after coronary artery bypass graft surgery.

Journal Article Ann Thorac Surg · June 2011 BACKGROUND: Inclusion of a measure of left ventricular diastolic dysfunction (LVDD) may improve risk prediction after cardiac surgery. Current LVDD grading guidelines rely on echocardiographic variables that are not always available or aligned to allow gra ... Full text Link to item Cite

The ultrasound brain helmet: new transducers and volume registration for in vivo simultaneous multi-transducer 3-D transcranial imaging.

Journal Article IEEE Trans Ultrason Ferroelectr Freq Control · June 2011 Featured Publication Because stroke remains an important and time-sensitive health concern in developed nations, we present a system capable of fusing 3-D transcranial ultrasound volumes acquired from two sides of the head. This system uses custom sparse array transducers buil ... Full text Link to item Cite

Dual matrix arrays integrated into scanner for increased SNR of ultrasound brain helmet

Journal Article Proceedings - IEEE Ultrasonics Symposium · December 1, 2010 In response to the high prevalence of stroke, we propose a system for scanning simultaneously via both temporal bone windows. The characteristics of this window and system limitations guide the design of custom matrix arrays. We present operational arrays ... Full text Cite

S100B and brain natriuretic peptide predict functional neurological outcome after intracerebral haemorrhage.

Journal Article Biomarkers · September 2009 Featured Publication OBJECTIVE: To determine the predictive value of S100b and brain natriuretic peptide (BNP) in order to determine accurately and quickly a discharge prognosis after primary supratentorial intracerebral haemorrhage (ICH). METHODS: After IRB approval and infor ... Full text Link to item Cite

Apolipoprotein E modifies neurological outcome by affecting cerebral edema but not hematoma size after intracerebral hemorrhage in humans.

Journal Article J Stroke Cerebrovasc Dis · 2009 Featured Publication INTRODUCTION: To address the mechanisms by which apoE polymorphism affects functional outcome after intracerebral hemorrhage in humans, we tested the hypothesis that the presence of the APOE4 allele results in amplified inflammatory responses and increased ... Full text Link to item Cite

The ultrasound brain helmet for 3D transcranial Doppler imaging

Journal Article Proceedings - IEEE Ultrasonics Symposium · 2009 Featured Publication Transcranial Doppler imaging with contrast enhancement is a promising approach for visualizing a variety of cerebrovascular diseases requiring rapid treatment to minimize long-term effects. To address the time-sensitive nature of these diseases, we present ... Full text Cite

Real-time 3-D contrast-enhanced transcranial ultrasound and aberration correction.

Journal Article Ultrasound Med Biol · September 2008 Featured Publication Contrast-enhanced (CE) transcranial ultrasound (US) and reconstructed 3-D transcranial ultrasound have shown advantages over traditional methods in a variety of cerebrovascular diseases. We present the results from a novel ultrasound technique, namely real ... Full text Link to item Cite

Real-time 3D contrast-enhanced transcranial ultrasound

Journal Article Proceedings - IEEE Ultrasonics Symposium · 2007 Featured Publication Contrast-enhanced (CE) transcranial ultrasound (US) and reconstructed 3D transcranial ultrasound have shown advantages over traditional methods in a variety of cerebrovascular diseases. We present the results from a novel ultrasound technique, namely real- ... Full text Cite

APOE polymorphism is associated with risk of severe sepsis in surgical patients.

Journal Article Crit Care Med · November 2005 Featured Publication OBJECTIVE: To test for an association between apolipoprotein E (APOE) genotypes and the occurrence of severe sepsis in an elective surgical cohort. DESIGN: Prospective, observational, single cohort study. SETTING: Sixteen-bed surgical intensive care unit ( ... Full text Link to item Cite

A novel therapeutic derived from apolipoprotein E reduces brain inflammation and improves outcome after closed head injury.

Journal Article Exp Neurol · March 2005 Featured Publication Although apolipoprotein E4 (APOE4) was initially identified as a susceptibility gene for the development of Alzheimer's disease, the presence of the APOE4 allele is also associated with poor outcome after acute brain injury. One mechanism by which apoE may ... Full text Link to item Cite

APOE genotype and an ApoE-mimetic peptide modify the systemic and central nervous system inflammatory response.

Journal Article J Biol Chem · December 5, 2003 Featured Publication Human apolipoprotein E is the major apolipoprotein expressed in the brain and exists as three isoforms, designated E2, E3, and E4. Although evidence suggests that apolipoprotein E plays an important role in modifying systemic and brain inflammatory respons ... Full text Link to item Cite

Cerebral embolization during cardiac surgery: impact of aortic atheroma burden.

Other Br J Anaesth · November 2003 BACKGROUND: Aortic atheromatous disease is known to be associated with an increased risk of perioperative stroke in the setting of cardiac surgery. In this study, we sought to determine the relationship between cerebral microemboli and aortic atheroma burd ... Full text Link to item Cite

Burkitt lymphoma arising in organ transplant recipients: a clinicopathologic study of five cases.

Journal Article Am J Surg Pathol · June 2003 Featured Publication We report five cases of Burkitt lymphoma arising in organ transplant recipients. There were four men and one woman with a mean age of 35 years. All were solid organ recipients with three renal, one liver, and one double lung transplantation. The time inter ... Full text Link to item Cite

Protective effect of apolipoprotein E-mimetic peptides on N-methyl-D-aspartate excitotoxicity in primary rat neuronal-glial cell cultures.

Journal Article Neuroscience · 2003 Featured Publication Apolipoprotein E (apoE) is a 34-kD protein with multiple biological properties. Recent clinical and preclinical observations implicate a role for apoE in modifying the response of the brain to focal and global ischemia. One mechanism by which apoE might ex ... Full text Link to item Cite

Apolipoprotein E protects against NMDA excitotoxicity.

Journal Article Neurobiol Dis · October 2002 Featured Publication Preclinical and clinical evidence implicates a role for endogenous apolipoprotein E in modifying the response of the brain to focal and global ischemia. To investigate whether apoE modulates the neuronal response to glutamate excitotoxicity, we exposed pri ... Full text Link to item Cite

Serum creatinine patterns in coronary bypass surgery patients with and without postoperative cognitive dysfunction.

Other Anesth Analg · July 2002 UNLABELLED: Renal dysfunction is common after coronary artery bypass graft (CABG) surgery. We have previously shown that CABG procedures complicated by stroke have a threefold greater peak serum creatinine level relative to uncomplicated surgery. However, ... Full text Link to item Cite

Differential cerebral gene expression during cardiopulmonary bypass in the rat: evidence for apoptosis?

Journal Article Anesth Analg · June 2002 Featured Publication UNLABELLED: Cardiopulmonary bypass (CPB) is associated with a spectrum of cerebral injuries. The molecular changes in the brain that might contribute to these injuries are not clearly known. We sought to determine whether the expression of apoptotic genes ... Full text Link to item Cite

Downregulation of microglial activation by apolipoprotein E and apoE-mimetic peptides.

Journal Article Exp Neurol · January 2001 Featured Publication Apolipoprotein E plays an important role in recovery from acute brain injury and risk of developing Alzheimer's disease. We demonstrate that biologically relevant concentrations of apoE suppress microglial activation and release of TNFalpha and NO in a dos ... Full text Link to item Cite

Endogenous apolipoprotein E suppresses LPS-stimulated microglial nitric oxide production.

Journal Article Neuroreport · March 9, 1998 Featured Publication The human apolipoprotein (apo) E4 isoform is associated with an increased risk for Alzheimer's disease (AD) and poor prognosis after acute CNS injury. Addition of human apoE inhibits murine microglial activation in culture, suggesting that microglia might ... Full text Link to item Cite

Apolipoprotein E suppresses glial cell secretion of TNF alpha.

Journal Article J Neuroimmunol · June 1997 Featured Publication Apolipoprotein E (apoE) is a 299 amino acid protein with multiple biological functions. Initially described in the context of cholesterol metabolism, apoE also has immunomodulatory properties and recent evidence has implicated a role for apoE in neurologic ... Full text Link to item Cite

Cloning and Characterization of a cDNA Encoding a Novel Fatty Acid Binding Protein from Rat Brain

Journal Article Journal of Neurochemistry · November 1994 Abstract: We have adopted a polymerase chain reaction approach to identify and clone a cDNA that contains the complete coding sequence of a novel fatty acid binding protein (FABP) from a rat brain λgt10 library. Sequencing of ... Full text Open Access Cite

Requirements for species-specific papovavirus DNA replication

Journal Article Journal of Virology · December 1989 Replication of papovavirus DNA requires a functional replication origin, a virus-encoded protein, large T antigen, and species-specific permissive factors. How these components interact to initiate and sustain viral DNA replication is not known. To ... Full text Open Access Cite