Scholars@Duke
Carl Berg

Carl Berg

Professor Emeritus of Medicine
Medicine, Gastroenterology
carl.berg@duke.edu
Box 3923, Durham, NC 27710
330 Trent Drive, Hanes House Room 225, Durham, NC 27710

Selected Publications

Improved liver transplant outcomes for patients with hilar cholangiocarcinoma following implementation of the MMAT-3 policy.

Journal Article Liver Transpl · November 6, 2025 In 2019, the United Network for Organ Sharing (UNOS) policy for patients with hilar cholangiocarcinoma (hCCA) changed from granting a Model for End-Stage Liver Disease (MELD) exception score of 22 with 10% escalation every 3 months to a median MELD at tran ... Full text Link to item Cite

Hepatitis B Virus NAT Positive Donors in Non-Hepatic Organ Transplant: Quantifying Viral Loads to Optimize Recipient Risk Stratification and Management in the Prevention of Donor-Derived Infection.

Journal Article Clin Transplant · July 2025 Transplantation is one of the few life-saving therapies for patients with end-stage organ disease, yet organ availability remains restrictive. Expanding donors to include those with hepatitis B virus (HBV) infection, incorporating HBV nucleic acid amplific ... Full text Link to item Cite

Transforming the logistics of liver transplantation with normothermic machine perfusion: Clinical impact versus cost.

Journal Article Liver Transpl · June 1, 2025 Normothermic machine perfusion (NMP) facilitates the utilization of marginal liver allografts. It remains unknown whether clinical benefits offset additional costs in the real-world setting. We performed a comparison of outcomes and hospitalization costs f ... Full text Link to item Cite

Advances in the treatment of hepatocellular carcinoma: An overview of the current and evolving therapeutic landscape for clinicians.

Journal Article CA Cancer J Clin · 2025 Hepatocellular carcinoma (HCC) is the sixth most common malignancy and the third leading cause of cancer-related death worldwide. Contemporary advances in systemic and locoregional therapies have led to changes in peer-reviewed guidelines regarding systemi ... Full text Link to item Cite

Real-world Experiences in the Transplantation of Hepatitis C-NAAT-positive Organs.

Journal Article Transplant Direct · November 2023 BACKGROUND: Hepatitis C virus (HCV) nucleic acid amplification test (NAAT)-positive donors have increased the organ pool. Direct-acting antivirals (DAAs) have led to high rates of treatment success and sustained virologic response (SVR) in recipients with ... Full text Link to item Cite

Transplanting hepatitis B surface antigen-positive livers in the United States: Outcomes and opportunities.

Journal Article Am J Transplant · August 2023 Livers from donors with positive hepatitis B surface antigens (HBsAg+) have been used to expand the donor pool; however, outcome data are limited. We aim to evaluate survival following liver transplant (LT) from HBsAg+ donors. Using the United Network for ... Full text Link to item Cite

LR-3 and LR-4 Lesions Are More Likely to Be Hepatocellular Carcinoma in Transplant Patients with LR-5 or LR-TR Lesions.

Conference Dig Dis Sci · November 2022 BACKGROUND: Liver Imaging Reporting and Data System (LI-RADS) classifies liver nodules from LR-1 to LR-5 based on risk for hepatocellular carcinoma (HCC). It is challenging to know the nature of the LR-3 and LR-4 lesions. AIMS: To test our hypothesis that ... Full text Link to item Cite

Left lateral segment liver volume is not correlated with anthropometric measures.

Journal Article HPB (Oxford) · December 2021 BACKGROUND: Liver transplantation is definitive therapy for end stage liver disease in pediatric patients. Living donor liver transplantation (LDLT) with the left lateral segment (LLS) is often a feasible option. However, the size of LLS is an important fa ... Full text Link to item Cite

The Impact of the 2017 Kidney Allocation Policy Change on Simultaneous Liver-Kidney Utilization and Outcomes.

Journal Article Liver Transpl · August 2021 Historically in the United States, kidneys for simultaneous liver-kidney transplantation (SLKT) candidates were allocated with livers, prioritizing SLKT recipients over much of the kidney waiting list. A 2017 change in policy delineated renal function crit ... Full text Link to item Cite

Effects of Sofosbuvir-Based Hepatitis C Treatment Regimens on Calcineurin Inhibitor Dosing in Liver and Kidney Transplant Recipients.

Journal Article Exp Clin Transplant · February 2021 OBJECTIVES: Available data have suggested that directacting antivirals for hepatitis C virus may decrease calcineurin inhibitor concentrations. In this study, our aim was to determine the effects of hepatitis C directacting antivirals on calcineurin inhibi ... Full text Link to item Cite

Need for Pretransplant Midodrine Does Not Negatively Impact Simultaneous Liver-kidney Transplant Outcomes.

Journal Article Transplant Direct · January 2021 BACKGROUND: Midodrine is often needed pretransplant to improve hemodynamics in simultaneous liver-kidney transplant candidates. Previous research has shown that patients requiring midodrine before kidney transplant alone have increased posttransplant risk ... Full text Link to item Cite

Immune Thrombocytopenia Associated with Hepatitis B Virus and Autoimmune Hepatitis and Recovery of Platelet Count following Liver Transplantation.

Journal Article Case Rep Transplant · 2021 Immune thrombocytopenia is a consumptive coagulopathy that can be either idiopathic or associated with infectious or autoimmune etiologies. Here, we present a case of immune thrombocytopenia in the setting of acute liver failure due to coexisting diagnoses ... Full text Link to item Cite

Textbook Outcomes in Liver Transplantation.

Journal Article World J Surg · October 2020 BACKGROUND: Textbook outcome (TO) is an emerging concept within multiple surgical domains, which represents a novel effort to define a standardized, composite quality benchmark based on multiple postoperative endpoints that represent the ideal "textbook" h ... Full text Link to item Cite

Transplant Outcomes in Older Patients With Nonalcoholic Steatohepatitis Compared to Alcohol-related Liver Disease and Hepatitis C.

Journal Article Transplantation · June 2020 BACKGROUND: Patients with nonalcoholic steatohepatitis (NASH) are waitlisted at older ages than individuals with other liver diseases, but the effect of age on liver transplantation (LT) outcomes in this population and whether it differs from other etiolog ... Full text Link to item Cite

Dysregulated activation of fetal liver programme in acute liver failure.

Journal Article Gut · June 2019 OBJECTIVE: Uncertainty about acute liver failure (ALF) pathogenesis limits therapy. We postulate that ALF results from excessive reactivation of a fetal liver programme that is induced in hepatocytes when acutely injured livers regenerate. To evaluate this ... Full text Link to item Cite

The impact of human leukocyte antigen donor and recipient serotyping and matching on liver transplant graft failure in primary sclerosing cholangitis, autoimmune hepatitis, and primary biliary cholangitis.

Journal Article Clin Transplant · October 2018 Human leukocyte antigen (HLA) serotyping is not considered to have significant impact on liver graft survival and does not factor into U.S. organ allocation. Immune-related liver diseases such as primary sclerosing cholangitis (PSC), autoimmune hepatitis ( ... Full text Link to item Cite

DonorNet and Biases in Decision-Making: An Organ Offer Simulation Study.

Conference AMERICAN JOURNAL OF TRANSPLANTATION · June 1, 2018 Link to item Cite

Single-Center Long-Term Analysis of Combined Liver-Lung Transplant Outcomes.

Journal Article Transplant Direct · May 2018 BACKGROUND: Combined lung-liver transplantation (LLT) applies 2 technically challenging transplants in 1 patient with severe 2-organ failure. METHODS: Institutional medical records and United Network for Organ Sharing database were queried for patients at ... Full text Open Access Link to item Cite

Transplant Drug Interactions and a Word of Caution for the HIV Provider. A Case Report.

Journal Article Open Forum Infect Dis · April 2018 Electronic medical record platforms fail to support provider alerts when a drug is discontinued. Protease inhibitors, often boosted by ritonavir or cobicistat, increase the serum concentration of calcineurin inhibitors. This case demonstrates acute liver t ... Full text Open Access Link to item Cite

Patterns of Resistance-Associated Substitutions in Patients With Chronic HCV Infection Following Treatment With Direct-Acting Antivirals.

Journal Article Gastroenterology · March 2018 BACKGROUND & AIMS: Little is known about substitutions that mediate resistance of hepatitis C virus (HCV) to direct-acting antivirals (DAAs), due to the small number of patients with treatment failure in approval studies. It is important to identify resist ... Full text Link to item Cite

Biliary reconstructive techniques and associated anatomic variants in adult living donor liver transplantations: The adult-to-adult living donor liver transplantation cohort study experience.

Journal Article Liver Transpl · December 2017 Living donor liver transplantation (LDLT) is a technically demanding endeavor, requiring command of the complex anatomy of partial liver grafts. We examined the influence of anatomic variation and reconstruction techniques on surgical outcomes and graft su ... Full text Link to item Cite

Liver Transplantation for Nonalcoholic Fatty Liver Disease: Role of Bariatric Surgery for Comorbid Obesity

Journal Article Journal of Advanced Nutrition and Human Metabolism · June 23, 2016 Full text Cite

How reader perception of capsule affects interpretation of washout in hypervascular liver nodules in patients at risk for hepatocellular carcinoma.

Journal Article J Magn Reson Imaging · June 2016 PURPOSE: To determine whether reader perception of a capsule affects reader interpretation of washout in hypervascular liver nodules at dynamic magnetic resonance imaging (MRI) in patients at risk for hepatocellular carcinoma (HCC). MATERIALS AND METHODS: ... Full text Link to item Cite

The OPTN Deceased Donor Potential Study: Implications for Policy and Practice.

Journal Article Am J Transplant · June 2016 The Organ Procurement and Transplantation Network (OPTN) Deceased Donor Potential Study, funded by the Health Resources and Services Administration, characterized the current pool of potential deceased donors and estimated changes through 2020. The goal wa ... Full text Link to item Cite

Nonalcoholic Fatty Liver Disease: Key Considerations Before and After Liver Transplantation.

Journal Article Dig Dis Sci · May 2016 Nonalcoholic fatty liver disease (NAFLD) is the most common etiology of chronic liver disease in developed countries and is on trajectory to become the leading indication for liver transplantation in the USA and much of the world. Patients with NAFLD cirrh ... Full text Link to item Cite

Update on 2015 OPTN/UNOS Strategic Plan: Allocation of Effort and Distribution of Manpower

Journal Article Current Transplantation Reports · March 1, 2016 The process by which the United Network for Organ Sharing (UNOS) allocates its effort is central to the pursuit of its mission. UNOS serves to support the field of solid organ and vascularized composite allograft transplantation and donation, and its many ... Full text Cite

Effectiveness of Transarterial Embolization of Hepatocellular Carcinoma as a Bridge to Transplantation.

Journal Article J Vasc Interv Radiol · January 2016 PURPOSE: To assess the effectiveness of bland transarterial embolization of hepatocellular carcinoma (HCC) as a "bridge" to transplantation. MATERIALS AND METHODS: In this retrospective study, 117 patients with HCC that met Milan criteria underwent bland e ... Full text Link to item Cite

Liver Transplantation in 2016: An Update.

Journal Article N C Med J · 2016 Liver transplantation is a lifesaving intervention for patients with decompensated cirrhosis, certain malignancies, and genetic disorders associated with disordered liver metabolism. This commentary will discuss the indications for liver transplantation, t ... Full text Link to item Cite

Defining long-term outcomes with living donor liver transplantation in North America.

Conference Ann Surg · September 2015 OBJECTIVES: To compare long-term survival of living donor liver transplant (LDLT) at experienced transplant centers with outcomes of deceased donor liver transplant and identify key variables impacting patient and graft survival. BACKGROUND: The Adult-to-A ... Full text Link to item Cite

Concordance of hypervascular liver nodule characterization between the organ procurement and transplant network and liver imaging reporting and data system classifications.

Journal Article J Magn Reson Imaging · August 2015 PURPOSE: To determine the rate of agreement between the Organ Procurement and Transplant Network (OPTN) and Liver Imaging Reporting and Data System (LI-RADS) classifications for hypervascular liver nodules at least 1 cm in diameter, and for patient eligibi ... Full text Link to item Cite

Long-term quality of life after liver donation in the adult to adult living donor liver transplantation cohort study (A2ALL).

Journal Article J Hepatol · February 2015 BACKGROUND & AIMS: There are few long-term studies of the health-related quality of life (HRQOL) in living liver donors. This study aimed to characterize donor HRQOL in the Adult to Adult Living Donor Liver Transplantation Study (A2ALL) up to 11 years post ... Full text Link to item Cite

Excess mortality on the liver transplant waiting list: unintended policy consequences and Model for End-Stage Liver Disease (MELD) inflation.

Journal Article Hepatology · January 2015 UNLABELLED: The Model for End-Stage Liver Disease (MELD) allocation system for liver transplantation provides "exceptions" for diseases such as hepatocellular carcinoma (HCC). It was the aim of this study to assess equipoise between exception candidates an ... Full text Link to item Cite

Hepatitis C disease severity in living versus deceased donor liver transplant recipients: an extended observation study.

Journal Article Hepatology · April 2014 UNLABELLED: Donor factors influence hepatitis C virus (HCV) disease severity in liver transplant (LT) recipients. Living donors, because they are typically young and have short cold ischemic times, may be advantageous for HCV-infected patients. Among HCV-i ... Full text Link to item Cite

Photodynamic therapy provides local control of cholangiocarcinoma in patients awaiting liver transplantation.

Journal Article Am J Transplant · February 2014 Many transplant centers use endoscopically directed brachytherapy to provide locoregional control in patients with otherwise incurable cholangiocarcinoma (CCA) who are awaiting liver transplantation (LT). The use of endoscopic retrograde cholangiopancreato ... Full text Link to item Cite

Phase 1 study of N(1),N(11)‑diethylnorspermine (DENSPM) in patients with advanced hepatocellular carcinoma.

Journal Article Cancer Chemother Pharmacol · December 2013 PURPOSE: N(1),N(11)-diethylnorspermine (DENSPM), a synthetic analog of the naturally occurring polyamine spermine, can induce polyamine depletion and inhibit tumor cell growth. The objectives of this phase I study were to assess the safety, maximum-tolerat ... Full text Link to item Cite

Transmission of hepatitis B virus from an orthopedic surgeon with a high viral load.

Journal Article Clin Infect Dis · January 2013 BACKGROUND: During the evaluation of a needle-stick injury, an orthopedic surgeon was found to be unknowingly infected with hepatitis B virus (HBV) (viral load >17.9 million IU/mL). He had previously completed two 3-dose series of hepatitis B vaccine witho ... Full text Link to item Cite

Outcomes of living and deceased donor liver transplant recipients with hepatocellular carcinoma: results of the A2ALL cohort.

Journal Article Am J Transplant · November 2012 Hepatocellular carcinoma (HCC) represents an increasing fraction of liver transplant indications; the role of living donor liver transplant (LDLT) remains unclear. In the Adult-to-Adult Living Donor Liver Transplantation Cohort Study, patients with HCC and ... Full text Link to item Cite

Outcomes of liver transplant recipients with hepatitis C and human immunodeficiency virus coinfection.

Journal Article Liver Transpl · June 2012 Hepatitis C virus (HCV) is a controversial indication for liver transplantation (LT) in human immunodeficiency virus (HIV)-infected patients because of reportedly poor outcomes. This prospective, multicenter US cohort study compared patient and graft survi ... Full text Link to item Cite

Does external beam radiation therapy improve survival following transarterial chemoembolization for unresectable hepatocellular carcinoma?

Journal Article Gastrointestinal Cancer Research · January 1, 2012 Background: Transcatheter arterial chemoembolization (TACE) improves survival in patients with unresectable hepatocellular carcinoma (HCC). Partial liver radiotherapy with modern techniques has been shown to be safe. The purpose of this study was to evalua ... Cite

Regional variability in symptom-based MELD exceptions: a response to organ shortage?

Journal Article Am J Transplant · November 2011 MELD (model for end-stage liver disease) exception awards affect the liver allocation process. Award rates of specific nonhepatocellular carcinoma exceptions, termed symptom-based exceptions (SBE), differ across UNOS regions. We aimed to characterize the r ... Full text Link to item Cite

Liver transplant recipient survival benefit with living donation in the model for endstage liver disease allocation era.

Journal Article Hepatology · October 2011 UNLABELLED: Receipt of a living donor liver transplant (LDLT) has been associated with improved survival compared with waiting for a deceased donor liver transplant (DDLT). However, the survival benefit of liver transplant has been questioned for candidate ... Full text Link to item Cite

Laboratory test results after living liver donation in the adult-to-adult living donor liver transplantation cohort study.

Journal Article Liver Transpl · April 2011 Information on the long-term health of living liver donors is incomplete. Because changes in standard laboratory tests may reflect the underlying health of donors, results before and after donation were examined in the Adult-to-Adult Living Donor Liver Tra ... Full text Link to item Cite

Database comparison of the adult-to-adult living donor liver transplantation cohort study (A2ALL) and the SRTR U.S. Transplant Registry.

Journal Article Am J Transplant · July 2010 Data submitted by transplant programs to the Organ Procurement and Transplantation Network (OPTN) are used by the Scientific Registry of Transplant Recipients (SRTR) for policy development, performance evaluation and research. This study compared OPTN/SRTR ... Full text Link to item Cite

Virologic and clinical outcomes of hepatitis B virus infection in HIV-HBV coinfected transplant recipients.

Journal Article Am J Transplant · May 2010 Liver transplantation (LT) is the treatment of choice for end-stage liver disease, but is controversial in patients with human immunodeficiency virus (HIV) infection. Using a prospective cohort of HIV-hepatitis B virus (HBV) coinfected patients transplante ... Full text Link to item Cite

Pretransplant predictors of recovery of renal function after liver transplantation.

Journal Article Liver Transpl · April 2010 The Model for End-Stage Liver Disease system has given priority on the liver transplant waiting list to candidates with renal failure. This study determined the predictors of spontaneous recovery of renal function after transplantation in 1041 liver transp ... Full text Link to item Cite

Hospitalization rates before and after adult-to-adult living donor or deceased donor liver transplantation.

Journal Article Ann Surg · March 2010 OBJECTIVE: To compare rates of hospitalization before and after adult-to-adult living donor liver transplant (LDLT) and deceased donor liver transplant (DDLT). SUMMARY BACKGROUND DATA: LDLT recipients have been reported to have lower mortality but a higher ... Full text Link to item Cite

Accelerated treatment using intensity-modulated radiation therapy plus concurrent capecitabine for unresectable hepatocellular carcinoma.

Journal Article Cancer · November 1, 2009 BACKGROUND: : Patients with unresectable hepatocellular carcinoma (HCC) have limited treatment options. In this study, the authors investigated the feasibility, toxicity, and efficacy associated with intensity-modulated radiation therapy (IMRT) and concurr ... Full text Link to item Cite

Combined liver-kidney and liver transplantation in patients with renal failure outcomes in the MELD era.

Journal Article Transpl Int · September 2009 With the implementation of the Model for End-Stage Liver Disease (MELD) scoring system, the number of combined liver-kidney transplants (CLKT) has increased dramatically. The United Network for Organ Sharing (UNOS) dataset was analysed for adult recipients ... Full text Link to item Cite

Fully covered self-expandable metallic stents in the management of complex biliary leaks: preliminary data - a case series.

Journal Article Endoscopy · September 2009 Techniques for management of bile leaks include biliary sphincterotomy and stenting. Partially covered self-expandable metallic stents have been used in complex bile leaks, but they are associated with migration and hyperplasia. A fully covered self-expand ... Full text Link to item Cite

Liver and intestine transplantation in the United States 1998-2007.

Journal Article Am J Transplant · April 2009 Liver transplantation numbers in the United States remained constant from 2004 to 2007, while the number of waiting list candidates has trended down. In 2007, the waiting list was at its smallest since 1999, with adults > or =50 years representing the majo ... Full text Link to item Cite

Treatment of primary liver tumors with Yttrium-90 microspheres (TheraSphere) in high risk patients: analysis of survival and toxicities.

Journal Article Technol Cancer Res Treat · February 2009 This retrospective study was undertaken to obtain information regarding the survival and toxicities after Yttrium-90 microspheres treatment in patients with primary liver malignancies. Baseline, treatment, and follow-up data were collected and analyzed for ... Full text Link to item Cite

The role of anti-fibrinolytics, rFVIIa and other pro-coagulants: prophylactic versus rescue?

Journal Article Clin Liver Dis · February 2009 Patients who have liver disease experience an increased risk for bleeding and resulting complications. Diseases affecting the liver can cause a deficiency of pro-coagulant factors or induce a state of increased clot breakdown. Although traditional tests of ... Full text Link to item Cite

Addition of adult-to-adult living donation to liver transplant programs improves survival but at an increased cost.

Journal Article Liver Transpl · February 2009 Using outcomes data from the Adult-to-Adult Living Donor Liver Transplantation Cohort Study, we performed a cost-effectiveness analysis exploring the costs and benefits of living donor liver transplantation (LDLT). A multistage Markov decision analysis mod ... Full text Link to item Cite

NASH and cryptogenic cirrhosis: a histological analysis.

Journal Article Ann Hepatol · 2009 INTRODUCTION: Epidemiological studies indicate that nonalcoholic steatohepatitis (NASH) is a common cause of cirrhosis described as 'cryptogenic'. To address this from a histological perspective and to examine the significance of residual histological find ... Link to item Cite

Mechanical pleurodesis aided by peritoneal drainage: procedure for hepatic hydrothorax.

Journal Article Ann Thorac Surg · January 2009 BACKGROUND: Hepatic hydrothorax in the setting of decompensated cirrhosis is a challenging and common clinical problem. Traditional therapies such as diuretics and transjugular intrahepatic portosystemic shunts can be effective therapies in selected patien ... Full text Link to item Cite

Liver and intestine transplantation in the United States, 1997-2006.

Journal Article Am J Transplant · April 2008 Liver transplantation in 2006 generally resembled previous years, with fewer candidates waiting for deceased donor liver transplants (DDLT), continuing a trend initiated with the implementation of the model for end-stage liver disease (MELD). Candidate age ... Full text Link to item Cite

Unresectable cholangiocarcinoma: comparison of survival in biliary stenting alone versus stenting with photodynamic therapy.

Journal Article Clin Gastroenterol Hepatol · March 2008 BACKGROUND & AIMS: Photodynamic therapy (PDT) for unresectable cholangiocarcinoma is associated with improvement in cholestasis, quality of life, and potentially survival. We compared survival in patients with unresectable cholangiocarcinoma undergoing end ... Full text Link to item Cite

A case of vanishing bile duct syndrome and IBD secondary to Hodgkin's lymphoma.

Journal Article Nat Clin Pract Gastroenterol Hepatol · January 2008 BACKGROUND: A 39-year-old man presented with a 2-month history of abdominal pain, jaundice, non-bloody diarrhea, weakness, and weight loss. Initial evaluation revealed intrahepatic ductopenia consistent with vanishing bile duct syndrome and IBD, type uncla ... Full text Link to item Cite

Hypercoagulation and thrombophilia in liver disease.

Journal Article J Thromb Haemost · January 2008 A complex balance exists between endogenous procoagulants and the anticoagulant system in liver disease patients. Hypercoagulable events occur in cirrhosis patients despite the well-known bleeding diathesis of liver disease. These events may be clinically ... Full text Link to item Cite

Improvement in survival associated with adult-to-adult living donor liver transplantation.

Journal Article Gastroenterology · December 2007 BACKGROUND & AIMS: More than 2000 adult-to-adult living donor liver transplantations (LDLT) have been performed in the United States, yet the potential benefit to liver transplant candidates of undergoing LDLT compared with waiting for deceased donor liver ... Full text Link to item Cite

Donor factors predicting recipient survival after liver retransplantation: the retransplant donor risk index.

Journal Article Am J Transplant · August 2007 The use of extended criteria liver donors (ECD) is controversial, especially in the setting of retransplantation. The aims of this study are to investigate the effects of ECD grafts on retransplantation and to develop a predictive mortality index in liver ... Full text Link to item Cite

Hepatocellular carcinoma recurrence and death following living and deceased donor liver transplantation.

Journal Article Am J Transplant · June 2007 We examined mortality and recurrence of hepatocellular carcinoma (HCC) among 106 transplant candidates with cirrhosis and HCC who had a potential living donor evaluated between January 1998 and February 2003 at the nine centers participating in the Adult-t ... Full text Link to item Cite

Methylphenidate-induced autoimmune hepatitis.

Journal Article Dig Dis Sci · February 2007 Full text Link to item Cite

Coagulation disorders and hemostasis in liver disease: pathophysiology and critical assessment of current management.

Journal Article Hepatology · October 2006 Normal coagulation has classically been conceptualized as a Y-shaped pathway, with distinct "intrinsic" and "extrinsic" components initiated by factor XII or factor VIIa/tissue factor, respectively, and converging in a "common" pathway at the level of the ... Full text Link to item Cite

Survival after adult liver transplantation does not correlate with transplant center case volume in the MELD era.

Journal Article Am J Transplant · October 2006 It has been demonstrated that low-volume orthotopic liver transplant centers have poorer outcomes compared to high-volume centers. In light of the recent significant changes in liver transplantation, we performed an analysis of transplant center procedure ... Full text Link to item Cite

Resolution of decompensated cirrhosis from Wilson's disease with zinc monotherapy: a potential therapeutic option?

Journal Article Clin Gastroenterol Hepatol · August 2006 BACKGROUND & AIMS: Wilson's disease is a genetic autosomal-recessive copper deposition disorder often presenting with neurologic or hepatic symptoms. In cases of hepatic presentation, treatment usually is initiated with potentially toxic copper chelators, ... Full text Link to item Cite

Coagulopathy does not fully protect hospitalized cirrhosis patients from peripheral venous thromboembolism.

Journal Article Am J Gastroenterol · July 2006 OBJECTIVE: Despite the endogenous coagulopathy of cirrhosis, some patients with cirrhosis experience thrombophilic states. This study aims to determine the incidence and predictors of venous thromboembolism (VTE), such as deep vein thrombosis (DVT) and pul ... Full text Link to item Cite

Re-treatment of chronic hepatitis C patients after relapse: efficacy of peginterferon-alpha-2a (40 kDa) and ribavirin.

Journal Article J Viral Hepat · July 2006 We conducted a randomized multinational study to determine whether 48 weeks of re-treatment with peginterferon-alpha-2a (40 kDa) plus ribavirin would induce a sustained virological response (SVR) in relapsed chronic hepatitis C patients. Patients who had p ... Full text Link to item Cite

SRTR center-specific reporting tools: Posttransplant outcomes.

Journal Article Am J Transplant · 2006 Measuring and monitoring performance--be it waiting list and posttransplant outcomes by a transplant center, or organ donation success by an organ procurement organization and its partnering hospitals--is an important component of ensuring good care for pe ... Full text Link to item Cite

Comparison of the grading of esophageal varices by transnasal endoluminal ultrasound and esophagogastroduodenoscopy.

Journal Article Clin Gastroenterol Hepatol · August 2005 BACKGROUND & AIMS: Esophagogastroduodenoscopy (EGD) is the current standard for evaluating esophageal varices, yet there is no universally accepted system of grading varices endoscopically and several studies have shown interobserver variability of endosco ... Full text Link to item Cite

EMR of ampullary gangliocytic paragangliomas.

Journal Article Gastrointest Endosc · August 2005 Full text Link to item Cite

Model for End-Stage Liver Disease (MELD) predicts nontransplant surgical mortality in patients with cirrhosis.

Journal Article Ann Surg · August 2005 OBJECTIVE: We sought to determine the ability of the Model for End-Stage Liver Disease (MELD) score to predict 30-day postoperative mortality for patients with cirrhosis undergoing nontransplant surgical procedures. SUMMARY BACKGROUND DATA: The Child-Pugh ... Full text Link to item Cite

Living donor liver transplantation: the historical and cultural basis of policy decisions and ongoing ethical questions.

Journal Article Health Policy · May 2005 Adult-to-adult living donor liver transplantation (LDLT) is in a state of flux. Technical innovations and demand have outpaced internal and external regulatory efforts. This has led to a wide array of centers performing LDLT for a variety of indications wi ... Full text Link to item Cite

Cost minimization in endoscopy center scheduling: a case-controlled study.

Journal Article J Clin Gastroenterol · April 2005 BACKGROUND: Traditional endoscopy center scheduling often results in nonurgent inpatient endoscopic procedures being delayed until late in the day and can prolong length of hospital stay and costs. We report the first controlled study designed to evaluate ... Full text Link to item Cite

Preoperative delta-MELD score does not independently predict mortality after liver transplantation.

Journal Article Am J Transplant · October 2004 Changes in model for end-stage liver disease (MELD) score of > or = 5 points over 30 days (delta-MELD) is an independent predictor for death in patients awaiting liver transplantation. The aim of the current study was to determine if a positive change in M ... Full text Link to item Cite

Identification of a human heme exporter that is essential for erythropoiesis.

Journal Article Cell · September 17, 2004 FLVCR, a member of the major facilitator superfamily of transporter proteins, is the cell surface receptor for feline leukemia virus, subgroup C. Retroviral interference with FLVCR display results in a loss of erythroid progenitors (colony-forming units-er ... Full text Link to item Cite

Recurrent demyelinating myelitis associated with hepatitis C viral infection.

Journal Article J Neurol Sci · September 15, 2004 We report a 46-year-old-man who developed recurrent myelitis associated with hepatitis C viral (HCV) infection. Spinal cord biopsy showed acute demyelination without evidence of vasculitis. Antibodies to HCV were present in the CSF; HCV RNA was not detecte ... Full text Link to item Cite

Characterization of a human plasma membrane heme transporter in intestinal and hepatocyte cell lines.

Journal Article Am J Physiol Gastrointest Liver Physiol · June 2001 Heme is the most bioavailable form of dietary iron and a component of many cellular proteins. Controversy exists as to whether heme uptake occurs via specific transport mechanisms or passive diffusion. The aims of this study were to quantify cellular heme ... Full text Link to item Cite

Hepatitis C-induced hepatic allograft injury is associated with a pretransplantation elevated viral replication rate.

Journal Article Hepatology · August 2000 Hepatitis C virus (HCV) allograft infection after liver transplantation follows a variable but accelerated course compared with the nontransplantation population. Predictors of outcome and mechanisms of reinfection remain elusive. The accelerated HCV-induc ... Full text Link to item Cite

Severe cholestasis related to intraconazole for the treatment of onychomycosis.

Journal Article Am J Gastroenterol · December 1999 We describe a case of prolonged cholestasis temporally associated with the use of itraconazole for onychomycosis. Peak bilirubin level of 32.0 mg/dl was documented approximately 2 months after discontinuation of the patient's itraconazole therapy, with sym ... Full text Link to item Cite

Image of the month

Journal Article Gastroenterology · January 1, 1999 Full text Cite

Hepatocellular expression of glucose-6-phosphatase is unaltered during hepatic regeneration.

Journal Article Am J Physiol · October 1998 Gluconeogenesis and glycogenolysis are essential hepatic functions required for glucose homeostasis. During the initial phase of hepatic regeneration, the immediate-early genes (IEG) are rapidly expressed, and the IEG RL-1 encodes for glucose-6-phosphatase ... Full text Link to item Cite

Portal hypertensive stomapathy: a newly described entity and its successful treatment by placement of a transjugular intrahepatic portosystemic shunt.

Journal Article Am J Gastroenterol · June 1997 We report the case of a 68-yr-old woman who had previously undergone a total colectomy and ileostomy for Crohn's disease limited to the colon. She subsequently had recurrent episodes of severe stomal bleeding and was discovered to have micronodular cirrhos ... Link to item Cite

A 68-year-old woman was admitted to the hospital because of hepatic encephalopathy

Journal Article New England Journal of Medicine · March 27, 1997 Full text Cite

Hepatic regeneration is associated with preservation of microsomal glucuronidation.

Journal Article Hepatology · November 1996 Significant controversy exists regarding the regulation of glucuronidation during the process of hepatic regeneration. We used a partial hepatectomy rat model to elucidate the effects of hepatic regeneration on the various components of the microsomal gluc ... Full text Link to item Cite

Two kinetically-distinct components of UDP-glucuronic acid transport in rat liver endoplasmic reticulum.

Journal Article Biochim Biophys Acta · September 4, 1996 Previous studies have documented the presence of protein-mediated transport of UDP-glucuronic acid (UDP-GlcUA) in rat liver endoplasmic reticulum (ER). Measurement of uptake at varying concentrations of high specific activity [beta-32P]UDP-GlcUA has reveal ... Full text Link to item Cite

Primary biliary cirrhosis immunopathogenesis and optimum management

Journal Article Clinical Immunotherapeutics · January 1, 1996 Primary biliary cirrhosis is a well-characterised disorder of autoimmune origin whose exact pathogenesis remains poorly understood. Population studies have suggested an association with human leucocyte antigen (HLA)-DRS, and patients are universally positi ... Full text Cite

Evidence for a low Km transporter for non-transferrin-bound iron in isolated rat hepatocytes.

Journal Article Am J Physiol · October 1995 Non-transferrin-bound iron (NTBI) plays an important role in the hepatocellular injury induced by iron overload. However, the mechanism responsible for NTBI uptake into hepatocytes remains poorly defined. The purpose of this study was to define the kinetic ... Full text Link to item Cite

Membrane translocation and regulation of uridine diphosphate-glucuronic acid uptake in rat liver microsomal vesicles.

Journal Article Gastroenterology · January 1995 BACKGROUND/AIMS: Hepatic glucuronidation is quantitatively the most important conjugation reaction by which an array of endogenous compounds and xenobiotics undergo biotransformation and detoxification. The active site of the uridine diphosphate (UDP) gluc ... Full text Link to item Cite

Characterization of UDP-glucuronic acid transport in rat liver microsomal vesicles with photoaffinity analogs.

Journal Article Biochim Biophys Acta · October 12, 1994 The endoplasmic reticulum (ER) of rat liver contains several well characterized UDP-glucuronosyltransferases (UGTs), membrane-bound proteins of 50-54 kDa, and also less well identified UDP-glucosyltransferases, with nucleotide binding sites located on the ... Full text Link to item Cite

Primary biliary cirrhosis: new therapeutic directions.

Journal Article Scand J Gastroenterol Suppl · 1992 The immunologic mechanisms responsible for the development of primary biliary cirrhosis (PBC) remain poorly defined, although recent investigations have provided new clues as to the role of cellular membrane proteins such as the mitochondrial autoantigens ... Full text Link to item Cite

Zollinger-Ellison syndrome.

Journal Article Med Clin North Am · July 1991 As clinical experience with patients with ZES has grown, increasing recognition has been made of the broad spectrum of symptoms associated with gastrinomas. Diarrhea and acid-induced esophageal injury have taken their place alongside chronic peptic ulcer d ... Full text Link to item Cite

Tube cecostomy as a cause of cecal pseudotumor.

Journal Article Endoscopy · July 1991 A 60-year-old male presented with findings on radiographic and physical examination which were compatible with colonic obstruction. A tube cecostomy was performed. Colonoscopy seven months later revealed a pseudotumor composed of granulation tissue in the ... Full text Link to item Cite

Metabolic liver disease

Journal Article Current Opinion in Gastroenterology · January 1, 1991 Diseases that fall into the category of metabolic liver diseases are generally considered to include disorders of hepatic synthesis and degradation or regulation of a diverse variety of endogenous compounds. The spectrum of abnormalities ranges from disord ... Full text Cite