Charles Edward Spritzer

Journal Article Osteoarthr Cartil Open · March 2025 OBJECTIVE: We sought to measure the deformation of tibiofemoral cartilage immediately following a 3-mile treadmill run, as well as the recovery of cartilage thickness the following day. To enable these measurements, we developed and validated deep learning ... Full text Link to item Cite

Does Tibial Plateau Slope and Depth Influence ACL Strain In Vivo?

Journal Article Orthop J Sports Med · December 2024 BACKGROUND: The anterior cruciate ligament (ACL) is loaded under tension when the tibia translates anteriorly relative to the femur. The shape of the articular surfaces of the tibiofemoral joint may influence the amount of anterior tibial translation under ... Full text Link to item Cite

A comparison of three methods for establishing an ACL reference length in vivo.

Journal Article J Biomech · November 2024 As anterior cruciate ligament (ACL) injuries are highly prevalent among active individuals, it is vital to better understand the loading conditions which lead to injury. One method for doing so is through measurement of dynamic, in vivo ACL strain. To meas ... Full text Link to item Cite

High angular resolution diffusion imaging (HARDI) of porcine menisci: a comparison of diffusion tensor imaging and generalized q-sampling imaging.

Journal Article Quant Imaging Med Surg · April 3, 2024 BACKGROUND: Diffusion magnetic resonance imaging (MRI) allows for the quantification of water diffusion properties in soft tissues. The goal of this study was to characterize the 3D collagen fiber network in the porcine meniscus using high angular resoluti ... Full text Link to item Cite

Influence of running on femoroacetabular joint bone-to-bone distances.

Journal Article J Orthop Res · April 2024 There is limited data quantifying the influence of running on hip cartilage mechanics. The goal of this investigation was to quantify changes in hip joint bone-to-bone distance in response to a 3-mile treadmill run. We acquired magnetic resonance (MR) imag ... Full text Link to item Cite

Automated segmentation and prediction of intervertebral disc morphology and uniaxial deformations from MRI.

Journal Article Osteoarthr Cartil Open · September 2023 OBJECTIVE: The measurement of in vivo intervertebral disc (IVD) mechanics may be used to understand the etiology of IVD degeneration and low back pain (LBP). To this end, our lab has developed methods to measure IVD morphology and uniaxial compressive defo ... Full text Link to item Cite

The Predicted Position of the Knee Near the Time of ACL Rupture Is Similar Between 2 Commonly Observed Patterns of Bone Bruising on MRI: Response.

Journal Article Am J Sports Med · July 2023 Full text Link to item Cite

Differential Diagnosis of Metatarsalgia.

Journal Article Semin Musculoskelet Radiol · June 2023 Lesser (or central) metatarsalgia is defined as pain in the forefoot under or around the lesser metatarsals and their respective metatarsophalangeal joints. Two common causes of central metatarsalgia are Morton's neuroma (MN) and plantar plate (PP) injury. ... Full text Link to item Cite

Auto-segmentation of the tibia and femur from knee MR images via deep learning and its application to cartilage strain and recovery.

Journal Article J Biomech · March 2023 The ability to efficiently and reproducibly generate subject-specific 3D models of bone and soft tissue is important to many areas of musculoskeletal research. However, methodologies requiring such models have largely been limited by lengthy manual segment ... Full text Link to item Cite

Elevated In Vivo ACL Strain Is Associated With a Straight Knee in Both the Sagittal and the Coronal Planes.

Journal Article Am J Sports Med · February 2023 BACKGROUND: Noncontact anterior cruciate ligament (ACL) injuries typically occur during deceleration movements such as landing or cutting. However, conflicting data have left the kinematic mechanisms leading to these injuries unclear. Quantifying the influ ... Full text Link to item Cite

In vivo intervertebral disc mechanical deformation following a treadmill walking "stress test" is inversely related to T1rho relaxation time.

Journal Article Osteoarthritis Cartilage · January 2023 OBJECTIVE: To assess the in vivo relationship between the mechanical response of intervertebral discs (IVDs) to dynamic activity and IVD biochemical composition assessed via T1rho relaxation imaging. DESIGN: Eighteen asymptomatic participants with no histo ... Full text Link to item Cite

The Predicted Position of the Knee Near the Time of ACL Rupture Is Similar Between 2 Commonly Observed Patterns of Bone Bruising on MRI.

Journal Article Am J Sports Med · January 2023 BACKGROUND: Bone bruises observed on magnetic resonance imaging (MRI) can provide insight into the mechanisms of noncontact anterior cruciate ligament (ACL) injury. However, it remains unclear whether the position of the knee near the time of injury differ ... Full text Link to item Cite

Prospective Multireader Evaluation of Photon-counting CT for Multiple Myeloma Screening.

Journal Article Radiol Imaging Cancer · November 2022 Purpose To determine whether photon-counting CT (PCCT) acquisition of whole-body CT images provides similar quantitative image quality and reader satisfaction for multiple myeloma screening at lower radiation doses than does standard energy-integrating det ... Full text Link to item Cite

Magic angle effect on diffusion tensor imaging in ligament and brain.

Journal Article Magn Reson Imaging · October 2022 PURPOSE: To evaluate the magic angle effect on diffusion tensor imaging (DTI) measurements in rat ligaments and mouse brains. METHODS: Three rat knee joints and three mouse brains were scanned at 9.4 T using a modified 3D diffusion-weighted spin echo pulse ... Full text Link to item Cite

Use of a Novel Multimodal Imaging Technique to Model In Vivo Quadriceps Force and ACL Strain During Dynamic Activity.

Journal Article Am J Sports Med · August 2022 BACKGROUND: Quadriceps loading of the anterior cruciate ligament (ACL) may play a role in the noncontact mechanism of ACL injury. Musculoskeletal modeling techniques are used to estimate the intrinsic force of the quadriceps acting at the knee joint. PURPO ... Full text Link to item Cite

Design and validation of a semi-automatic bone segmentation algorithm from MRI to improve research efficiency.

Journal Article Sci Rep · May 12, 2022 Segmentation of medical images into different tissue types is essential for many advancements in orthopaedic research; however, manual segmentation techniques can be time- and cost-prohibitive. The purpose of this work was to develop a semi-automatic segme ... Full text Link to item Cite

Correction to: MRI nomenclature for musculoskeletal infection.

Journal Article Skeletal Radiol · May 2022 Full text Link to item Cite

Lumbar intervertebral disc diurnal deformations and T2 and T1rho relaxation times vary by spinal level and disc region.

Journal Article Eur Spine J · March 2022 PURPOSE: Magnetic resonance imaging (MRI) is routinely used to evaluate spine pathology; however, standard imaging findings weakly correlate to low back pain. Abnormal disc mechanical function is implicated as a cause of back pain but is not assessed using ... Full text Open Access Link to item Cite

Obesity impacts the mechanical response and biochemical composition of patellofemoral cartilage: An in vivo, MRI-based investigation.

Journal Article J Biomech · March 2022 Obesity is a primary risk factor for osteoarthritis. While previous work has addressed relationships between in vivo cartilage mechanics, composition, and obesity in the tibiofemoral joint, there is limited information on these relationships in the patello ... Full text Link to item Cite

Mechanical metrics may show improved ability to predict osteoarthritis compared to T1rho mapping.

Journal Article J Biomech · December 2, 2021 Changes in cartilage structure and composition are commonly observed during the progression of osteoarthritis (OA). Importantly, quantitative magnetic resonance imaging (MRI) methods, such as T1rho relaxation imaging, can noninvasively provide in vivo metr ... Full text Link to item Cite

MRI nomenclature for musculoskeletal infection.

Journal Article Skeletal Radiol · December 2021 The Society of Skeletal Radiology (SSR) Practice Guidelines and Technical Standards Committee identified musculoskeletal infection as a White Paper topic, and selected a Committee, tasked with developing a consensus on nomenclature for MRI of musculoskelet ... Full text Link to item Cite

Increasing BMI increases lumbar intervertebral disc deformation following a treadmill walking stress test.

Journal Article J Biomech · May 24, 2021 High body mass index (BMI) and obesity have been implicated as risk factors for lumbar degenerative disc disease and low back pain. Despite this, there is limited in vivo data to quantify how obesity influences the mechanical function of intervertebral dis ... Full text Link to item Cite

Effect of walking on in vivo tibiofemoral cartilage strain in ACL-deficient versus intact knees.

Journal Article J Biomech · February 12, 2021 Anterior cruciate ligament (ACL) rupture alters knee kinematics and contributes to premature development of osteoarthritis. However, there is limited data regarding the in vivo biomechanical response of tibiofemoral cartilage to activities of daily living ... Full text Link to item Cite

The Characteristic Recovery Time as a Novel, Noninvasive Metric for Assessing In Vivo Cartilage Mechanical Function.

Journal Article Ann Biomed Eng · December 2020 Osteoarthritis (OA) is a disease characterized by the degeneration of cartilage tissue, and is a leading cause of disability in the United States. The clinical diagnosis of OA includes the presence of pain and radiographic imaging findings, which typically ... Full text Link to item Cite

The Influence of Obesity and Meniscal Coverage on In Vivo Tibial Cartilage Thickness and Strain.

Journal Article Orthop J Sports Med · December 2020 BACKGROUND: Obesity, which potentially increases loading at the knee, is a common and modifiable risk factor for the development of knee osteoarthritis. The menisci play an important role in distributing joint loads to the underlying cartilage. However, th ... Full text Link to item Cite

Dose and Recovery Response of Patellofemoral Cartilage Deformations to Running.

Journal Article Orthop J Sports Med · December 2020 BACKGROUND: Running is a common recreational activity that provides many health benefits. However, it remains unclear how patellofemoral cartilage is affected by varied running distances and how long it takes the cartilage to recover to its baseline state ... Full text Link to item Cite

In Vivo Mechanical Function of the Distal Radial Ulnar Ligaments During Rotation of the Wrist.

Journal Article J Hand Surg Am · November 2020 PURPOSE: The purpose of this study was to investigate changes in length of the volar and dorsal radioulnar ligaments (VRULs and DRULs), and the distal radioulnar joint (DRUJ) space during unweighted and weighted rotation of the wrist using magnetic resonan ... Full text Link to item Cite

In vivo attachment site to attachment site length and strain of the ACL and its bundles during the full gait cycle measured by MRI and high-speed biplanar radiography: Response.

Journal Article J Biomech · August 26, 2020 Full text Link to item Cite

Phase 2 clinical trial of TORC1 inhibition with everolimus in men with metastatic castration-resistant prostate cancer.

Journal Article Urol Oncol · March 2020 BACKGROUND: Activation of the PI3K-Akt-mTOR signaling pathway is common in advanced castration resistant prostate cancer (CRPC), typically through PTEN loss. Preclinical studies suggest that Akt-driven CaP cells are genetically susceptible to mammalian tar ... Full text Link to item Cite

Quantifying the biochemical state of knee cartilage in response to running using T1rho magnetic resonance imaging.

Journal Article Sci Rep · February 5, 2020 Roughly 20% of Americans run annually, yet how this exercise influences knee cartilage health is poorly understood. To address this question, quantitative magnetic resonance imaging (MRI) can be used to infer the biochemical state of cartilage. Specificall ... Full text Open Access Link to item Cite

In vivo attachment site to attachment site length and strain of the ACL and its bundles during the full gait cycle measured by MRI and high-speed biplanar radiography.

Journal Article J Biomech · January 2, 2020 The purpose of this study was to measure in vivo attachment site to attachment site lengths and strains of the anterior cruciate ligament (ACL) and its bundles throughout a full cycle of treadmill gait. To obtain these measurements, models of the femur, ti ... Full text Link to item Cite

In Vivo Anterior Cruciate Ligament Deformation During a Single-Legged Jump Measured by Magnetic Resonance Imaging and High-Speed Biplanar Radiography.

Journal Article Am J Sports Med · November 2019 BACKGROUND: The in vivo mechanics of the anterior cruciate ligament (ACL) and its bundles during dynamic activities are not completely understood. An improved understanding of how the ACL stabilizes the knee is likely to aid in the identification and preve ... Full text Link to item Cite

In vivo assessment of the interaction of patellar tendon tibial shaft angle and anterior cruciate ligament elongation during flexion.

Journal Article J Biomech · June 11, 2019 A potential cause of non-contact anterior cruciate ligament (ACL) injury is landing on an extended knee. In line with this hypothesis, studies have shown that the ACL is elongated with decreasing knee flexion angle. Furthermore, at low flexion angles the p ... Full text Link to item Cite

A New Stress Test for Knee Joint Cartilage.

Journal Article Sci Rep · February 19, 2019 Cartilage metabolism-both the synthesis and breakdown of cartilage constituents and architecture-is influenced by its mechanical loading. Therefore, physical activity is often recommended to maintain cartilage health and to treat or slow the progression of ... Full text Link to item Cite

Activities of daily living influence tibial cartilage T1rho relaxation times.

Journal Article J Biomech · January 3, 2019 Quantitative T1rho magnetic resonance imaging (MRI) can potentially help identify early-stage osteoarthritis (OA) by non-invasively assessing proteoglycan concentration in articular cartilage. T1rho relaxation times are negatively correlated with proteogly ... Full text Link to item Cite

Selective Enzymatic Digestion of Proteoglycans and Collagens Alters Cartilage T1rho and T2 Relaxation Times.

Journal Article Ann Biomed Eng · January 2019 Our objective was to determine the relationship of T1rho and T2 relaxation mapping to the biochemical and biomechanical properties of articular cartilage through selective digestion of proteoglycans and collagens. Femoral condyles were harvested from porci ... Full text Link to item Cite

Effects of Anterior Cruciate Ligament Deficiency on Tibiofemoral Cartilage Thickness and Strains in Response to Hopping.

Journal Article Am J Sports Med · January 2019 BACKGROUND: Changes in knee kinematics after anterior cruciate ligament (ACL) injury may alter loading of the cartilage and thus affect its homeostasis, potentially leading to the development of posttraumatic osteoarthritis. However, there are limited in v ... Full text Link to item Cite

A Comparison of Knee Abduction Angles Measured by a 3D Anatomic Coordinate System Versus Videographic Analysis: Implications for Anterior Cruciate Ligament Injury.

Journal Article Orthop J Sports Med · January 2019 BACKGROUND: Knee positions involved in noncontact anterior cruciate ligament (ACL) injury have been studied via analysis of injury videos. Positions of high ACL strain have been identified in vivo. These methods have supported different hypotheses regardin ... Full text Link to item Cite

Pharmacodynamic study of radium-223 in men with bone metastatic castration resistant prostate cancer.

Journal Article PLoS One · 2019 BACKGROUND: Radium-223 is a targeted alpha-particle therapy that improves survival in men with metastatic castration resistant prostate cancer (mCRPC), particularly in men with elevated serum levels of bone alkaline phosphatase (B-ALP). We hypothesized tha ... Full text Link to item Cite

Economics of MRI Operations After Implementation of Interpersonal Skills Training.

Journal Article J Am Coll Radiol · December 2018 PURPOSE: Examine the cost of MRI operations before and after implementation of interpersonal skills training to reduce unanticipated patient-related events in an academic medical center. METHODS: Teams at four MRI sites (two hospital-based, two freestandin ... Full text Link to item Cite

Obesity alters the in vivo mechanical response and biochemical properties of cartilage as measured by MRI.

Journal Article Arthritis Res Ther · October 17, 2018 BACKGROUND: Obesity is a primary risk factor for the development of knee osteoarthritis (OA). However, there remains a lack of in vivo data on the influence of obesity on knee cartilage mechanics and composition. The purpose of this study was to determine ... Full text Link to item Cite

Determination of the Position of the Knee at the Time of an Anterior Cruciate Ligament Rupture for Male Versus Female Patients by an Analysis of Bone Bruises: Response.

Journal Article Am J Sports Med · September 2018 Full text Link to item Cite

In Vivo Assessment of Exercise-Induced Glenohumeral Cartilage Strain.

Journal Article Orthop J Sports Med · July 2018 BACKGROUND: The human shoulder joint is the most mobile joint in the body. While in vivo shoulder kinematics under minimally loaded conditions have been studied, it is unclear how glenohumeral cartilage responds to high-demand loaded exercise. HYPOTHESIS: ... Full text Open Access Link to item Cite

Determination of the Position of the Knee at the Time of an Anterior Cruciate Ligament Rupture for Male Versus Female Patients by an Analysis of Bone Bruises.

Journal Article Am J Sports Med · June 2018 BACKGROUND: The incidence of anterior cruciate ligament (ACL) ruptures is 2 to 4 times higher in female athletes as compared with their male counterparts. As a result, a number of recent studies have addressed the hypothesis that female and male patients s ... Full text Link to item Cite

A magnetic resonance imaging framework for quantifying intervertebral disc deformation in vivo: Reliability and application to diurnal variations in lumbar disc shape.

Journal Article J Biomech · April 11, 2018 Low back pain is a significant socioeconomic burden in the United States and lumbar intervertebral disc degeneration is frequently implicated as a cause. The discs play an important mechanical role in the spine, yet the relationship between disc function a ... Full text Open Access Link to item Cite

A comparison of patellofemoral cartilage morphology and deformation in anterior cruciate ligament deficient versus uninjured knees.

Journal Article J Biomech · January 23, 2018 Anterior cruciate ligament (ACL) deficient patients have an increased rate of patellofemoral joint (PFJ) osteoarthritis (OA) as compared to the general population. Although the cause of post-injury OA is multi-factorial, alterations in joint biomechanics m ... Full text Link to item Cite

In Vivo Tibial Cartilage Strains in Regions of Cartilage-to-Cartilage Contact and Cartilage-to-Meniscus Contact in Response to Walking.

Journal Article Am J Sports Med · October 2017 BACKGROUND: There are currently limited human in vivo data characterizing the role of the meniscus in load distribution within the tibiofemoral joint. Purpose/Hypothesis: The purpose was to compare the strains experienced in regions of articular cartilage ... Full text Link to item Cite

Relationship between T1rho magnetic resonance imaging, synovial fluid biomarkers, and the biochemical and biomechanical properties of cartilage.

Journal Article J Biomech · April 11, 2017 Non-invasive techniques for quantifying early biochemical and biomechanical changes in articular cartilage may provide a means of more precisely assessing osteoarthritis (OA) progression. The goals of this study were to determine the relationship between T ... Full text Link to item Cite

Sports medicine of the foot & ankle, the role of imaging

Chapter · February 8, 2017 As is true for orthopedics in general, the assessment of a sports related injuries of the foot and ankle begins with a good history and physical. While many maladies are readily diagnosed, often a differential remains. In these instances, imaging assessmen ... Full text Cite

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Other Clin Gastroenterol Hepatol · December 2016 Full text Link to item Cite

An analysis of changes in in vivo cartilage thickness of the healthy ankle following dynamic activity.

Journal Article J Biomech · September 6, 2016 Abnormal cartilage loading after injury is believed to be an important factor leading to post-traumatic ankle osteoarthritis. Due to the viscoelastic behavior of cartilage, it is possible to measure localized cartilage strains from changes in thickness fol ... Full text Link to item Cite

Effect of normal gait on in vivo tibiofemoral cartilage strains.

Journal Article J Biomech · September 6, 2016 Altered cartilage loading is believed to be associated with osteoarthritis development. However, there are limited data regarding the influence of normal gait, an essential daily loading activity, on cartilage strains. In this study, 8 healthy subjects wit ... Full text Link to item Cite

Magnetic resonance imaging evaluation of meniscoid superior labrum: normal variant or superior labral tear.

Journal Article Radiol Bras · 2016 OBJECTIVE: The objective of this study was to determine the incidence of a "meniscoid" superior labrum. MATERIALS AND METHODS: This was a retrospective analysis of 582 magnetic resonance imaging examinations of shoulders. Of those 582 examinations, 110 wer ... Full text Link to item Cite

Knee Kinematics During Noncontact Anterior Cruciate Ligament Injury as Determined From Bone Bruise Location.

Journal Article Am J Sports Med · October 2015 BACKGROUND: The motions causing noncontact anterior cruciate ligament (ACL) injury remain unclear. Tibiofemoral bone bruises are believed to be the result of joint impact near the time of ACL rupture. The locations and frequencies of these bone bruises hav ... Full text Link to item Cite

In vivo cartilage strain increases following medial meniscal tear and correlates with synovial fluid matrix metalloproteinase activity.

Journal Article J Biomech · June 1, 2015 Meniscal tears are common injuries, and while partial meniscectomy is a frequent treatment option, general meniscus loss is a risk factor for the development of osteoarthritis. The goal of this study was to measure the in vivo tibiofemoral cartilage contac ... Full text Open Access Link to item Cite

In vivo measurement of localized tibiofemoral cartilage strains in response to dynamic activity.

Journal Article Am J Sports Med · February 2015 BACKGROUND: Altered local mechanical loading may disrupt normal cartilage homeostasis and play a role in the progression of osteoarthritis. Currently, there are limited data quantifying local cartilage strains in response to dynamic activity in normal or i ... Full text Link to item Cite

The effects of femoral graft placement on cartilage thickness after anterior cruciate ligament reconstruction.

Journal Article J Biomech · January 3, 2014 Altered joint motion has been thought to be a contributing factor in the long-term development of osteoarthritis after ACL reconstruction. While many studies have quantified knee kinematics after ACL injury and reconstruction, there is limited in vivo data ... Full text Link to item Cite

Intercondylar synovial septum in two patients with nail-patella syndrome.

Journal Article J Knee Surg · December 2013 This case report describes the arthroscopic findings in two patients with nail-patella syndrome (NPS). In both cases, a midline synovial septum was encountered that completely subdivided the knee into medial and lateral compartments. One patient required t ... Full text Link to item Cite

Bone marrow biopsy: RNA isolation with expression profiling in men with metastatic castration-resistant prostate cancer--factors affecting diagnostic success.

Journal Article Radiology · December 2013 PURPOSE: To determine the rate at which computed tomographically guided pelvic percutaneous bone biopsy in men with metastatic castration-resistant prostate cancer (mCRPC) yields adequate tissue for genomic profiling and to identify issues likely to affect ... Full text Link to item Cite

High body mass index is associated with increased diurnal strains in the articular cartilage of the knee.

Journal Article Arthritis Rheum · October 2013 OBJECTIVE: Obesity is an important risk factor for osteoarthritis (OA) and is associated with changes in both the biomechanical and inflammatory environments within the joint. However, the relationship between obesity and cartilage deformation is not fully ... Full text Link to item Cite

Following unenhanced MRI assessment for local recurrence after surgical resection of mesenchymal soft tissue tumors, do additional gadolinium-enhanced images change reader confidence or diagnosis?

Journal Article Eur J Radiol · May 2013 PURPOSE: Evaluate if gadolinium enhanced MR imaging (GeMRI) improves confidence, changes the final diagnosis, or improves accuracy in the assessment of musculoskeletal (MSK) tumor residual or recurrence following surgical resection. We also assess if diffe ... Full text Link to item Cite

In vivo measurement of ACL length and relative strain during walking.

Journal Article J Biomech · February 1, 2013 Although numerous studies have addressed the effects of ACL injury and reconstruction on knee joint motion, there is currently little data available describing in vivo ACL strain during activities of daily living. Data describing in vivo ACL strain during ... Full text Link to item Cite

Diurnal variations in articular cartilage thickness and strain in the human knee.

Journal Article J Biomech · February 1, 2013 Due to the biphasic viscoelastic nature of cartilage, joint loading may result in deformations that require times on the order of hours to fully recover. Thus, cartilaginous tissues may exhibit cumulative strain over the course of each day. The goal of thi ... Full text Link to item Cite

The effects of a valgus collapse knee position on in vivo ACL elongation.

Journal Article Ann Biomed Eng · January 2013 There are conflicting data regarding what motions increase ACL injury risk. More specifically, the mechanical role of valgus collapse positions during ACL injury remains controversial. Our objective was to evaluate ACL elongation in a model that mimics kne ... Full text Link to item Cite

The effect of modified Broström-Gould repair for lateral ankle instability on in vivo tibiotalar kinematics.

Journal Article Am J Sports Med · September 2012 BACKGROUND: Lateral ankle instability leads to an increased risk of tibiotalar joint osteoarthritis. Previous studies have found abnormal tibiotalar joint motions with lateral ankle instability that may contribute to this increased incidence of osteoarthri ... Full text Link to item Cite

The role of dynamic contrast-enhanced magnetic resonance imaging in the diagnosis and management of patients with vascular malformations.

Journal Article J Vasc Surg · September 2012 OBJECTIVE: Vascular malformations are uncommon but may confer significant morbidity. Limitations in diagnosis and treatment result from inadequate classification schema and diagnostic algorithms. The crucial distinction is between high-flow and low-flow le ... Full text Link to item Cite