Scholars@Duke
Brian Gary Czito

Brian Gary Czito

Professor of Radiation Oncology
Radiation Oncology
Box 3085 Med Ctr, Durham, NC
05145B Morris Clinic, Durham, NC 27710

Selected Publications

Management of Metastic Liver Cancer

Chapter · January 1, 2024 The liver is the most common site for blood-borne metastasis from colorectal cancers, and is the dominant metastatic disease site just prior to death (Stewart et al. 2018). Until the early 1980s, it was generally accepted that hepatic metastases from color ... Full text Cite

Radiation Therapy

Chapter · January 1, 2024 Cite

Stereotactic body radiotherapy with or without selective dismutase mimetic in pancreatic adenocarcinoma: an adaptive, randomised, double-blind, placebo-controlled, phase 1b/2 trial.

Journal Article Lancet Oncol · December 2023 BACKGROUND: Stereotactic body radiotherapy (SBRT) has the potential to ablate localised pancreatic ductal adenocarcinoma. Selective dismutase mimetics sensitise tumours while reducing normal tissue toxicity. This trial was designed to establish the efficac ... Full text Link to item Cite

Ampullary Adenocarcinoma, Version 1.2023, NCCN Clinical Practice Guidelines in Oncology.

Journal Article J Natl Compr Canc Netw · July 2023 Ampullary cancers refer to tumors originating from the ampulla of Vater (the ampulla, the intraduodenal portion of the bile duct, and the intraduodenal portion of the pancreatic duct), while periampullary cancers may arise from locations encompassing the h ... Full text Link to item Cite

Comparing Outcomes of Oligometastases Treated with Hypofractionated Image-Guided Radiotherapy (HIGRT) with a Simultaneous Integrated Boost (SIB) Technique versus Metastasis Alone: A Multi-Institutional Analysis.

Journal Article Cancers (Basel) · May 13, 2022 PURPOSE: We previously reported on the clinical outcomes of treating oligometastases with radiation using an elective simultaneous integrated boost technique (SIB), delivering higher doses to known metastases and reduced doses to adjacent bone or nodal bas ... Full text Link to item Cite

External Beam Radiation Therapy for Primary Liver Cancers: An ASTRO Clinical Practice Guideline.

Journal Article Practical radiation oncology · January 2022 PurposeThis guideline provides evidence-based recommendations for the indications and technique-dose of external beam radiation therapy (EBRT) in hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (IHC).MethodsThe American ... Full text Cite

Corrigendum: Brain Metastases from Esophageal Squamous Cell Carcinoma: Clinical Characteristics and Prognosis.

Journal Article Front Oncol · 2022 [This corrects the article DOI: 10.3389/fonc.2021.652509.]. ... Full text Link to item Cite

Transfer learning for fluence map prediction in adrenal stereotactic body radiation therapy.

Conference Phys Med Biol · December 6, 2021 Objective:To design a deep transfer learning framework for modeling fluence map predictions for stereotactic body radiation therapy (SBRT) of adrenal cancer and similar sites that usually have a small number of cases.Approach:We developed a transfer learni ... Full text Link to item Cite

Oligometastases Treated With an Elective Simultaneous Integrated Boost Have Reduced Marginal Recurrence Rates.

Conference International journal of radiation oncology, biology, physics · November 2021 Purpose/objective(s)Radiation is increasingly used to treat oligometastatic patients (OM). Following metastasis directed radiation therapy, progression in nearby nodal basins or bones is common. We previously reported clinical outcomes of OM treat ... Full text Cite

The Role of Hypofractionated Radiation Therapy in the Management of Unresectable Hepatocellular Carcinoma (HCC).

Conference International journal of radiation oncology, biology, physics · November 2021 Purpose/objective(s)Management of HCC without surgical resection or transplantation is poorly defined with no standard. Stereotactic body radiation therapy (SBRT) or hypofractionated image-guided radiotherapy (HIGRT), is an evolving, non-invasive, ... Full text Cite

Toxicity and Dosimetric Parameters of Ablative Radiation Therapy in the Management of Patients with Child-Pugh B/C Liver Function and Unresectable Hepatocellular Carcinoma (HCC).

Conference International journal of radiation oncology, biology, physics · November 2021 Purpose/objective(s)To date there is no clear standard non-surgical therapeutic option for HCC patients. Ablative radiation therapy (SBRT/HIGRT) is an emerging non-invasive treatment for patients with HCC. However, there is concern about the risk ... Full text Cite

Pancreatic Adenocarcinoma, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology.

Journal Article J Natl Compr Canc Netw · April 1, 2021 Pancreatic cancer is the fourth leading cause of cancer-related death among men and women in the United States. A major challenge in treatment remains patients' advanced disease at diagnosis. The NCCN Guidelines for Pancreatic Adenocarcinoma provides recom ... Full text Link to item Cite

An Interpretable Planning Bot for Pancreas Stereotactic Body Radiation Therapy.

Journal Article Int J Radiat Oncol Biol Phys · March 15, 2021 PURPOSE: Pancreas stereotactic body radiation therapy (SBRT) treatment planning requires planners to make sequential, time-consuming interactions with the treatment planning system to reach the optimal dose distribution. We sought to develop a reinforcemen ... Full text Link to item Cite

Ipilimumab and Radiation in Patients with High-risk Resected or Regionally Advanced Melanoma.

Journal Article Clin Cancer Res · March 1, 2021 PURPOSE: In this prospective trial, we sought to assess the feasibility of concurrent administration of ipilimumab and radiation as adjuvant, neoadjuvant, or definitive therapy in patients with regionally advanced melanoma. PATIENTS AND METHODS: Twenty-fou ... Full text Link to item Cite

Brain Metastases from Esophageal Squamous Cell Carcinoma: Clinical Characteristics and Prognosis.

Conference Front Oncol · 2021 PURPOSE: Due to the low incidence of intracranial disease among patients with esophageal cancer (EC), optimal management for these patients has not been established. The aim of this real-world study is to describe the clinical characteristics, treatment ap ... Full text Link to item Cite

Deep Learning-Based Fluence Map Prediction for Pancreas Stereotactic Body Radiation Therapy With Simultaneous Integrated Boost.

Journal Article Adv Radiat Oncol · 2021 PURPOSE: Treatment planning for pancreas stereotactic body radiation therapy (SBRT) is a challenging task, especially with simultaneous integrated boost treatment approaches. We propose a deep learning (DL) framework to accurately predict fluence maps from ... Full text Link to item Cite

Evaluating treatment protocols for rectal squamous cell carcinomas: the Duke experience and literature.

Journal Article J Gastrointest Oncol · April 2020 BACKGROUND: Colorectal cancer is the third most common cancer in the United States and associated with significant morbidity and mortality. Within colorectal cancer histologies, squamous cell carcinomas (SCC) are rare compared to adenocarcinomas, with only ... Full text Link to item Cite

Multi-Institutional Analysis of Synchronous Prostate and Rectosigmoid Cancers.

Journal Article Front Oncol · 2020 Purpose: To perform a multi-institutional analysis of patients with synchronous prostate and rectosigmoid cancers. Materials and Methods: A retrospective review of Duke University and Durham Veterans Affairs Medical Center records was performed for men wit ... Full text Link to item Cite

Do Higher Radiation Doses with Concurrent Chemotherapy in the Definitive Treatment of Esophageal Cancer Improve Outcomes? A Meta-Analysis and Systematic Review.

Journal Article J Cancer · 2020 Background: To investigate the effects and safety profile of radiation dose escalation utilizing computerized tomography (CT) based radiotherapy techniques (including 3-Dimensional conformal radiotherapy, intensity-modulated radiotherapy and proton therapy ... Full text Link to item Cite

Fluence Map Prediction Using Deep Learning Models - Direct Plan Generation for Pancreas Stereotactic Body Radiation Therapy.

Journal Article Front Artif Intell · 2020 Purpose: Treatment planning for pancreas stereotactic body radiation therapy (SBRT) is a difficult and time-consuming task. In this study, we aim to develop a novel deep learning framework to generate clinical-quality plans by direct prediction of fluence ... Full text Open Access Link to item Cite

Comparison of neoadjuvant chemoradiotherapy and neoadjuvant chemotherapy for esophageal cancer: a meta-analysis.

Journal Article Future Oncol · July 2019 Aim: To compare the clinical efficacy of neoadjuvant chemoradiotherapy (nCRT) and neoadjuvant chemotherapy (nCT) for esophageal cancer. Methods: Randomized controlled trials reporting on the comparison of nCRT and nCT for esophageal cancer were identified. ... Full text Link to item Cite

Role of pelvic chemoradiation therapy in patients with initially metastatic anal canal cancer: A National Cancer Database review.

Journal Article Cancer · June 15, 2019 BACKGROUND: Although the management of localized anal canal squamous cell carcinomas is well established, the role of pelvic chemoradiation (CRT) in the treatment of patients presenting with synchronous metastatic (stage IV) disease is poorly defined. This ... Full text Link to item Cite

Low- vs. High-Dose Neoadjuvant Radiation in Trimodality Treatment of Locally Advanced Esophageal Cancer.

Journal Article J Gastrointest Surg · May 2019 BACKGROUND: The optimal dose of neoadjuvant radiation for locally advanced, resectable esophageal cancer remains controversial in the absence of randomized clinical trials, with conventional practice favoring the use of 50.4 vs. 41.4 Gy. METHODS: Retrospec ... Full text Link to item Cite

Pancreatic Adenocarcinoma, Version 1.2019.

Journal Article J Natl Compr Canc Netw · March 1, 2019 The NCCN Guidelines for Pancreatic Adenocarcinoma discuss the diagnosis and management of adenocarcinomas of the exocrine pancreas and are intended to assist with clinical decision-making. These NCCN Guidelines Insights discuss important updates to the 201 ... Full text Link to item Cite

Multi-institutional analysis of synchronous prostate and rectosigmoid cancers.

Conference Journal of Clinical Oncology · March 1, 2019 33 Background: Synchronous prostate cancer (PC) and rectosigmoid (RS) cancer (RSC) is a challenging clinical situation. Methods: A retrospective review of Duke University and Durham VA charts was performed for men with adenocarci ... Full text Cite

Hypofractionated Image-Guided Radiation Therapy With Simultaneous-Integrated Boost Technique for Limited Metastases: A Multi-Institutional Analysis.

Journal Article Front Oncol · 2019 Purpose: To perform a multi-institutional analysis following treatment of limited osseous and/or nodal metastases in patients using a novel hypofractionated image-guided radiotherapy with simultaneous-integrated boost (HIGRT-SIB) technique. Methods: Consec ... Full text Open Access Link to item Cite

Cancer of the Anal Canal

Chapter · January 1, 2019 Although anal squamous cell carcinoma (ASCC) is an uncommon malignancy, its incidence has been rising over the last two decades owing to the widespread prevalence of human papillomavirus infection in the US population. Anal cancer provides a paradigm for o ... Full text Cite

Total Neoadjuvant Therapy (TNT) in Rectal Cancer

Journal Article Current Colorectal Cancer Reports · December 1, 2018 Purpose of Review: This review summarizes the relevant literature on the use of total neoadjuvant therapy (TNT) for patients with locally advanced rectal cancer. It highlights the most notable literature published and briefly discusses future directions. R ... Full text Cite

Cancer of the anal region

Chapter · November 16, 2018 Cite

Association of Interim FDG-PET Imaging During Chemoradiation for Squamous Anal Canal Carcinoma With Recurrence.

Journal Article Int J Radiat Oncol Biol Phys · November 15, 2018 PURPOSE: Imaging parameters from 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET) before and after chemoradiation therapy (CRT) for anal canal cancer correlate with clinical outcomes. This prospective, hypothesis-generating pilot study inv ... Full text Link to item Cite

Intratreatment Response Assessment With 18F-FDG PET: Correlation of Semiquantitative PET Features With Pathologic Response of Esophageal Cancer to Neoadjuvant Chemoradiotherapy.

Journal Article Int J Radiat Oncol Biol Phys · November 15, 2018 PURPOSE: This prospective study seeks to extract semiquantitative positron emission tomography (PET) features from 18F-fluorodeoxyglucose PET scans performed before and during neoadjuvant chemoradiotherapy for esophageal cancer and to compare their accurac ... Full text Link to item Cite

The role of external beam radiotherapy in the treatment of hepatocellular cancer.

Journal Article Cancer · September 1, 2018 Hepatocellular carcinoma (HCC) is increasing in incidence and mortality. Although the prognosis remains poor, long-term survival has improved from 3% in 1970 to an 18% 5-year survival rate today. This is likely because of the introduction of well tolerated ... Full text Link to item Cite

The Selective Use of Radiation Therapy in Rectal Cancer Patients.

Journal Article Curr Oncol Rep · April 11, 2018 PURPOSE OF REVIEW: Colorectal cancer has a high global incidence, and standard treatment employs a multimodality approach. In addition to cure, minimizing treatment-related toxicity and improving the therapeutic ratio is a common goal. The following articl ... Full text Link to item Cite

Role of radiotherapy in locally advanced pancreatic cancer

Chapter · April 11, 2018 Pancreatic cancer carries a poor prognosis regardless of stage, and incidence and death rates are increasing. Pancreatic cancer is divided into four general categories, resectable, borderline resectable, locally advanced/unresectable, and metastatic. Only ... Full text Cite

Association between neoadjuvant chemoradiation and survival for patients with locally advanced rectal cancer.

Journal Article Colorectal Dis · December 2017 AIM: To examine the overall survival differences for the following neoadjuvant therapy modalities - no therapy, chemotherapy alone, radiation alone and chemoradiation - in a large cohort of patients with locally advanced rectal cancer. METHOD: Adults with ... Full text Link to item Cite

Pancreatic Adenocarcinoma, Version 2.2017, NCCN Clinical Practice Guidelines in Oncology.

Journal Article J Natl Compr Canc Netw · August 2017 Ductal adenocarcinoma and its variants account for most pancreatic malignancies. High-quality multiphase imaging can help to preoperatively distinguish between patients eligible for resection with curative intent and those with unresectable disease. System ... Full text Link to item Cite

Association Between Incomplete Neoadjuvant Radiotherapy and Survival for Patients With Locally Advanced Rectal Cancer.

Journal Article JAMA Surg · June 1, 2017 IMPORTANCE: Failing to complete chemotherapy adversely affects survival in patients with colorectal cancer. However, the effect of incomplete delivery of neoadjuvant radiotherapy is unclear. OBJECTIVE: To determine whether incomplete radiotherapy delivery ... Full text Link to item Cite

Safety and tolerability of veliparib combined with capecitabine plus radiotherapy in patients with locally advanced rectal cancer: a phase 1b study.

Journal Article Lancet Gastroenterol Hepatol · June 2017 BACKGROUND: Further optimisation of present standard chemoradiation is needed in patients with locally advanced rectal cancer. Veliparib, an oral poly(ADP-ribose) polymerase inhibitor, has been shown to enhance the antitumour activity of chemotherapy and r ... Full text Link to item Cite

Anal cancer

Chapter · May 10, 2017 Cite

Pancreatic cancer

Chapter · May 10, 2017 Cite

Total neoadjuvant therapy for rectal cancer: An emerging option.

Journal Article Cancer · May 1, 2017 The treatment of locally advanced rectal cancer (LARC) has benefited from improved surgical techniques and from the implementation of neoadjuvant chemoradiotherapy (CRT), which have markedly decreased the rates of local recurrence. However, distant metasta ... Full text Link to item Cite

Neoadjuvant long-course chemoradiation remains strongly favored over short-course radiotherapy by radiation oncologists in the United States.

Journal Article Cancer · April 15, 2017 BACKGROUND: Short-course radiotherapy (SC-RT) and long-course chemoradiotherapy (LC-CRT) are accepted neoadjuvant treatments of rectal cancer. In the current study, the authors surveyed US radiation oncologists to assess practice patterns and attitudes reg ... Full text Link to item Cite

Retrospective four-dimensional magnetic resonance imaging with image-based respiratory surrogate: a sagittal-coronal-diaphragm point of intersection motion tracking method.

Journal Article J Med Imaging (Bellingham) · April 2017 A four-dimensional magnetic resonance imaging (4-D-MRI) technique with Sagittal-Coronal-Diaphragm Point-of-Intersection (SCD-PoI) as a respiratory surrogate is proposed. To develop an image-based respiratory surrogate, the SCD-PoI motion tracking method is ... Full text Link to item Cite

Four-dimensional diffusion-weighted MR imaging (4D-DWI): a feasibility study.

Journal Article Med Phys · February 2017 PURPOSE: Diffusion-weighted Magnetic Resonance Imaging (DWI) has been shown to be a powerful tool for cancer detection with high tumor-to-tissue contrast. This study aims to investigate the feasibility of developing a four-dimensional DWI technique (4D-DWI ... Full text Link to item Cite

Interim FDG-PET imaging during neoadjuvant chemoradiotherapy for esophageal cancer: Correlation with pathologic response.

Conference Journal of Clinical Oncology · February 1, 2017 175 Background: In this prospective study we evaluated whether changes in metabolic tumor parameters on interim flurodeoxyglucose positron emission tomography (FDG-PET) performed during neoadjuvant chemoradiotherapy (CRT) for eso ... Full text Cite

Intensity-Modulated Radiation Therapy Is Not Associated with Perioperative or Survival Benefit over 3D-Conformal Radiotherapy for Rectal Cancer.

Journal Article J Gastrointest Surg · January 2017 INTRODUCTION: The use of intensity-modulated radiation therapy (IMRT) in rectal cancer has steadily increased over traditional 3D conformal radiotherapy (3D-CRT) due to perceived benefit of delivering higher treatment doses while minimizing exposure to sur ... Full text Link to item Cite

Evolution and Management of Treatment-Related Toxicity in Anal Cancer.

Journal Article Surg Oncol Clin N Am · January 2017 Over the past several decades, clinical trials have demonstrated improved disease-related outcomes in the definitive treatment of anal cancer. Although treatment with radiation and concurrent chemotherapy results in high rates of cure, significant acute an ... Full text Link to item Cite

The Use of Re-irradiation in Locally Recurrent, Non-metastatic Rectal Cancer.

Journal Article Ann Surg Oncol · October 2016 BACKGROUND: The optimal approach to patients with locally recurrent, non-metastatic rectal cancer is unclear. This study evaluates the outcomes and toxicity associated with pelvic re-irradiation. METHODS: Patients undergoing re-irradiation for locally recu ... Full text Link to item Cite

Radiation Therapy for Soft Tissue Sarcoma: Indications and Controversies for Neoadjuvant Therapy, Adjuvant Therapy, Intraoperative Radiation Therapy, and Brachytherapy.

Journal Article Surg Oncol Clin N Am · October 2016 Soft tissue sarcomas are rare mesenchymal cancers that pose a treatment challenge. Although small superficial soft tissue sarcomas can be managed by surgery alone, adjuvant radiotherapy in addition to limb-sparing surgery substantially increases local cont ... Full text Link to item Cite

Role of Adjuvant Radiotherapy in Locally Advanced Colonic Carcinoma in the Modern Chemotherapy Era.

Journal Article Ann Surg Oncol · March 2016 BACKGROUND: The role of adjuvant radiation therapy (RT) in the treatment of resected, locally advanced colon cancer is unclear. One randomized controlled trial (Intergroup-0130) addressed this question but failed to meet its accrual goals. Since this trial ... Full text Link to item Cite

Effect of combined neoadjuvant chemoradiation on overall survival for patients with locally advanced rectal cancer.

Conference Journal of Clinical Oncology · February 1, 2016 657 Background: Prospective randomized trials have demonstrated that neoadjuvant chemoradiation improves local control and results in a higher rate of sphincter-sparing surgery for patients with locally advanced rectal cancer. Ho ... Full text Cite

Nonoperative management of rectal cancer.

Journal Article Cancer · January 1, 2016 Surgery has long been the primary curative modality for localized rectal cancer. Neoadjuvant chemoradiation has significantly improved local control rates and, in a significant minority, eradicated all disease. Patients who achieve a pathologic complete re ... Full text Link to item Cite

Appropriate customization of radiation therapy for stage II and III rectal cancer: Executive summary of an ASTRO Clinical Practice Statement using the RAND/UCLA Appropriateness Method.

Journal Article Pract Radiat Oncol · 2016 PURPOSE: To summarize results of a Clinical Practice Statement on radiation therapy for stage II-III rectal cancer, which addressed appropriate customization of (neo)adjuvant radiation therapy and use of non-surgical therapy for patients who are inoperable ... Full text Link to item Cite

A current perspective on stereotactic body radiation therapy for pancreatic cancer.

Journal Article Onco Targets Ther · 2016 Pancreatic cancer is a formidable malignancy with poor outcomes. The majority of patients are unable to undergo resection, which remains the only potentially curative treatment option. The management of locally advanced (unresectable) pancreatic cancer is ... Full text Open Access Link to item Cite

Evaluation of Adjuvant Radiation Therapy for Resected Gallbladder Carcinoma: A Multi-institutional Experience.

Journal Article Ann Surg Oncol · December 2015 PURPOSE: The role of adjuvant radiation for gallbladder carcinoma (GBC) is uncertain. We combine the experience of six National Cancer Institute-designated cancer centers to explore the impact of adjuvant radiation following oncologic resection of GBC. MET ... Full text Link to item Cite

Analysis of perioperative radiation therapy in the surgical treatment of primary and recurrent retroperitoneal sarcoma.

Journal Article J Surg Oncol · September 2015 BACKGROUND: Radiation therapy (RT) is increasingly utilized in conjunction with surgery for the treatment of retroperitoneal soft tissue sarcomas (RPS). Despite multiple theoretical advantages of RT, its role in the surgical management of this disease rema ... Full text Link to item Cite

T2-weighted four dimensional magnetic resonance imaging with result-driven phase sorting.

Journal Article Med Phys · August 2015 PURPOSE: T2-weighted MRI provides excellent tumor-to-tissue contrast for target volume delineation in radiation therapy treatment planning. This study aims at developing a novel T2-weighted retrospective four dimensional magnetic resonance imaging (4D-MRI) ... Full text Link to item Cite

Adjuvant radiation therapy for pancreatic cancer: a review of the old and the new.

Journal Article J Gastrointest Oncol · August 2015 Surgery represents the only potential curative treatment option for patients diagnosed with pancreatic adenocarcinoma. Despite aggressive surgical management for patients deemed to be resectable, rates of local recurrence and/or distant metastases remain h ... Full text Link to item Cite

Neoadjuvant radiation therapy does not increase perioperative morbidity among patients undergoing gastrectomy for gastric cancer.

Journal Article J Surg Oncol · July 2015 BACKGROUND: Neoadjuvant radiation therapy (RT) as a component of the multimodality treatment of gastric cancer has demonstrated promising results. Data regarding its effect on perioperative safety are limited. METHODS: Adults undergoing gastrectomy for gas ... Full text Link to item Cite

Human papillomavirus tumor infection in esophageal squamous cell carcinoma.

Journal Article J Gastrointest Oncol · June 2015 The association between human papillomavirus (HPV) and esophageal squamous cell carcinoma (ESCC) has been recognized for over three decades. Recently, multiple meta-analyses have drawn upon existing literature to assess the strength of the HPV-ESCC linkage ... Full text Link to item Cite

The safety and tolerability of veliparib (V) plus capecitabine (C) and radiation (RT) in subjects with locally advanced rectal cancer (LARC): Results of a phase 1b study.

Conference Journal of Clinical Oncology · January 20, 2015 579 Background: Patients (pts) with LARC treated with neoadjuvant C/RT and then surgery have low rates of pathologic complete response (ypCR) and significant relapse rates. V is a potent, orally bioavailable PARP inhibitor that h ... Full text Cite

Cancer of the anal region

Chapter · January 7, 2015 Cite

Anal canal cancer

Chapter · January 1, 2015 Radiation therapy with concurrent chemotherapy is the standard treatment for patients with nonmetastatic squamous cell carcinoma of the anal canal. In the studies that established this approach, high rates of locoregional control have been reported, but th ... Full text Cite

Intraoperative radiotherapy for gastrointestinal malignancies: contemporary outcomes with multimodality therapy.

Journal Article Curr Oncol Rep · January 2015 The integration of intraoperative radiotherapy (IORT) into the multimodal treatment of gastrointestinal cancer is feasible and leads to high rates of local control. In-field tumoral control using IORT-containing strategies can be achieved in over 90 % of m ... Full text Link to item Cite

Colon Cancer

Chapter · January 1, 2015 Full text Cite

Intraoperative Irradiation

Chapter · January 1, 2015 Full text Cite

Incidence and prognostic impact of high-risk HPV tumor infection in cervical esophageal carcinoma.

Journal Article J Gastrointest Oncol · December 2014 BACKGROUND: Cervical esophageal carcinoma (CEC) is an uncommon malignancy. Limited data supports the use of definitive chemoradiotherapy (CRT) as primary treatment. Furthermore, the role of human papillomavirus (HPV) tumor infection in CEC remains unknown. ... Full text Link to item Cite

Patterns of failure for stage I ampulla of Vater adenocarcinoma: a single institutional experience.

Journal Article J Gastrointest Oncol · December 2014 BACKGROUND: Ampullary adenocarcinoma is a rare malignancy associated with a relatively favorable prognosis. Given high survival rates in stage I patients reported in small series with surgery alone, adjuvant chemoradiotherapy (CRT) has traditionally been r ... Full text Link to item Cite

Intraoperative radiotherapy in the treatment of gastrointestinal malignancies

Journal Article Translational Cancer Research · December 1, 2014 Intraoperative radiotherapy (IORT) is a technique that allows delivery of a single high dose of radiation to a target volume during surgery. Where conventional external beam radiation therapy (EBRT) is limited by the normal tissue tolerance of abdominal an ... Full text Cite

Is diaphragm motion a good surrogate for liver tumor motion?

Journal Article Int J Radiat Oncol Biol Phys · November 15, 2014 PURPOSE: To evaluate the relationship between liver tumor motion and diaphragm motion. METHODS AND MATERIALS: Fourteen patients with hepatocellular carcinoma (10 of 14) or liver metastases (4 of 14) undergoing radiation therapy were included in this study. ... Full text Link to item Cite

Investigation of sagittal image acquisition for 4D-MRI with body area as respiratory surrogate.

Journal Article Med Phys · October 2014 PURPOSE: The authors have recently developed a novel 4D-MRI technique for imaging organ respiratory motion employing cine acquisition in the axial plane and using body area (BA) as a respiratory surrogate. A potential disadvantage associated with axial ima ... Full text Link to item Cite

Radiosensitive orbital metastasis as presentation of occult colonic adenocarcinoma.

Journal Article BMJ Case Rep · September 19, 2014 An 82-year-old man presented with progressive right frontal headaches. The patient's history was significant for benign polyps on surveillance colonoscopy 2 years prior, without high-grade dysplasia or carcinoma. MRI revealed an enhancing lesion arising wi ... Full text Link to item Cite

Short-course versus long-course chemoradiation in rectal cancer--time to change strategies?

Journal Article Curr Treat Options Oncol · September 2014 There is significant debate regarding the optimal neoadjuvant regimen for resectable rectal cancer patients. Short-course radiotherapy, a standard approach throughout most of northern Europe, is generally defined as 25 Gy in 5 fractions over the course of ... Full text Link to item Cite

Definitive Chemoradiation Therapy for Cervical Esophageal Carcinoma: A Single-Institution Experience

Conference International Journal of Radiation Oncology*Biology*Physics · September 2014 Full text Cite

Pancreatic adenocarcinoma, version 2.2014: featured updates to the NCCN guidelines.

Journal Article J Natl Compr Canc Netw · August 2014 The NCCN Guidelines for Pancreatic Adenocarcinoma discuss the diagnosis and management of adenocarcinomas of the exocrine pancreas and are intended to assist with clinical decision-making. These NCCN Guidelines Insights summarize major discussion points fr ... Full text Link to item Cite

Patterns of recurrence after trimodality therapy for esophageal cancer.

Journal Article Cancer · July 15, 2014 BACKGROUND: Patterns of failure after neoadjuvant chemoradiotherapy and surgery for esophageal cancer are poorly defined. METHODS: All patients in the current study were treated with trimodality therapy for nonmetastatic esophageal cancer from 1995 to 2009 ... Full text Link to item Cite

Radiotherapy for Gastrointestinal Malignancies

Chapter · June 20, 2014 This chapter talks about four case studies of radiotherapy for gastrointestinal malignancies. One of the case study, a 65-year-old female presents with painless jaundice and diarrhea for 1 month. Labs show an elevation in liver function tests and total bil ... Full text Cite

The role of intraoperative radiation therapy in patients with pancreatic cancer.

Journal Article Semin Radiat Oncol · April 2014 Intraoperative radiation therapy (IORT) techniques allow for the delivery of high doses of radiation therapy while excluding part or all of the nearby dose-limiting sensitive structures. Therefore, the effective radiation dose is increased and local tumor ... Full text Link to item Cite

Four-dimensional magnetic resonance imaging using axial body area as respiratory surrogate: initial patient results.

Journal Article Int J Radiat Oncol Biol Phys · March 15, 2014 PURPOSE: To evaluate the feasibility of a retrospective binning technique for 4-dimensional magnetic resonance imaging (4D-MRI) using body area (BA) as a respiratory surrogate. METHODS AND MATERIALS: Seven patients with hepatocellular carcinoma (4 of 7) or ... Full text Link to item Cite

Cancer of the Anal Canal

Chapter · January 1, 2014 Full text Cite

Incidence and prognostic impact of high-risk HPV tumor infection in cervical esophageal carcinoma

Journal Article Journal of Gastrointestinal Oncology · January 1, 2014 Background: Cervical esophageal carcinoma (CEC) is an uncommon malignancy. Limited data supports the use of definitive chemoradiotherapy (CRT) as primary treatment. Furthermore, the role of human papillomavirus (HPV) tumor infection in CEC remains unknown. ... Full text Cite

Radiation therapy in anal and rectal cancer.

Journal Article Surg Oncol Clin N Am · July 2013 Historically, squamous cell carcinoma of the anal canal was treated with abdominoperineal resection. Nigro discovered that radiation therapy combined with 5-fluorouracil and mitomycin resulted in high rates of local control and colostomy-free and overall s ... Full text Link to item Cite

TU-G-134-01: 4D-MRI Using Body Area as Internal Respiratory Surrogate: Initial Patient Results.

Journal Article Med Phys · June 2013 PURPOSE: We have previously developed a novel 4D-MRI technique using body area (BA) as internal respiratory surrogate. This study is to demonstrate our initial patient results via validating the accuracy of tumor motion measurements and the improvement of ... Full text Link to item Cite

TH-C-141-07: T2-Weighted 4D-MRI with Combined Phase and Amplitude Sorting.

Journal Article Med Phys · June 2013 PURPOSE: T2-weighted MR provides excellent delineation of malignant liver lesions due to its superior tumor-to-tissue contrast. This study aims to develop a novel T2-weighted retrospective 4D-MRI technique for imaging organ/tumor respiratory motion with im ... Full text Link to item Cite

WE-C-116-07: Tumor Enhancement Using Deformable Image Registration for Four-Dimensional Magnetic Resonance Imaging (4D-MRI): A Feasibility Study.

Journal Article Med Phys · June 2013 PURPOSE: We have previously developed a 4D-MRI technique using the fast imaging sequence employing steady-state acquisition (FIESTA) sequence, which has suboptimal tumor-to-tissue contrast-to-noise ratio (CNR) due to its T2*/T1 weighting. This study invest ... Full text Link to item Cite

The role of local excision in invasive adenocarcinoma of the ampulla of Vater.

Journal Article J Gastrointest Oncol · March 2013 BACKGROUND: Ampulla of Vater carcinomas are rare malignancies that have been traditionally treated with radical surgical resection. Given the mortality associated with pancreaticoduodenectomy, some patients may benefit from local resection. A single-instit ... Full text Link to item Cite

Intraoperative pelvic brachytherapy for treatment of locally advanced or recurrent colorectal cancer.

Journal Article Tech Coloproctol · February 2013 Featured Publication BACKGROUND: The aim of this study was to evaluate the efficacy and morbidity of intraoperative radiation therapy (IORT) for advanced colorectal cancer. METHODS: All patients undergoing IORT for locally advanced rectal cancer from 2001-2009 were reviewed fo ... Full text Link to item Cite

Preoperative chemoradiotherapy for locally advanced gastric cancer.

Journal Article Radiat Oncol · January 4, 2013 BACKGROUND: To examine toxicity and outcomes for patients treated with preoperative chemoradiotherapy (CRT) for gastric cancer. METHODS: Patients with gastroesophageal (GE) junction (Siewert type II and III) or gastric adenocarcinoma who underwent neoadjuv ... Full text Link to item Cite

Patterns of Failure for Stage I Ampulla of Vater Adenocarcinoma: A Single Institutional Experience

Conference INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS · 2013 Full text Cite

Technical considerations in radiation therapy for gastroesophageal junction cancer.

Journal Article Semin Radiat Oncol · January 2013 Contemporary randomized trials have demonstrated that radiation therapy combined with chemotherapy and surgery improves survival in both the neoadjuvant and adjuvant treatment of gastroesophageal cancers. Consequently, radiation treatment planning and admi ... Full text Link to item Cite

Anal Cancer

Journal Article · November 15, 2012 This chapter provides an overview of the epidemiology, diagnosis, and treatment of the various tumors that arise in the anal canal and surrounding perianal skin. In particular, we focus on the evolution of treatment for squamous cell anal canal cancers, an ... Full text Cite

Oncology scan - gastrointestinal cancer.

Journal Article International journal of radiation oncology, biology, physics · October 2012 Full text Cite

Resected pancreatic neuroendocrine tumors: patterns of failure and disease-related outcomes with or without radiotherapy.

Journal Article Int J Radiat Oncol Biol Phys · July 15, 2012 Featured Publication PURPOSE: Pancreatic neuroendocrine tumors (NET) are rare and have better disease-related outcomes compared with pancreatic adenocarcinoma. Surgical resection remains the standard of care, although many patients present with locally advanced or metastatic d ... Full text Link to item Cite

Does preoperative therapy optimize outcomes in patients with resectable pancreatic cancer?

Journal Article J Surg Oncol · July 1, 2012 Featured Publication The objective of this study was to compare survival between all patients with radiographically resectable adenocarcinoma of the proximal pancreas who underwent preoperative chemoradiation therapy (PRE-OP CRT) or surgical exploration first (SURGERY) with "i ... Full text Link to item Cite

Pancreatic Adenocarcinoma, version 2.2012: featured updates to the NCCN Guidelines.

Journal Article J Natl Compr Canc Netw · June 1, 2012 The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Pancreatic Adenocarcinoma discuss the workup and management of tumors of the exocrine pancreas. These NCCN Guidelines Insights provide a summary and explanation of major changes to the ... Full text Link to item Cite

Potential novel drugs to combine with radiation in rectal cancer

Journal Article Current Colorectal Cancer Reports · June 1, 2012 The management of rectal cancer has seen significant advances in surgery, radiation therapy, and chemotherapy in recent years. These advances have translated into improved rates of local and distant disease control, survival, and quality of life for these ... Full text Cite

Neoadjuvant chemoradiation for potentially resectable gastric cancer.

Conference JOURNAL OF CLINICAL ONCOLOGY · May 20, 2012 Link to item Cite

Carcinoma of the ampulla of Vater: patterns of failure following resection and benefit of chemoradiotherapy.

Journal Article Ann Surg Oncol · May 2012 Featured Publication BACKGROUND: Ampullary carcinoma is a rare malignancy. Despite radical resection, survival rates remain low with high rates of local failure. We performed a single-institution outcomes analysis to define the role of concurrent chemoradiotherapy (CRT) in add ... Full text Link to item Cite

Pancreas

Chapter · March 28, 2012 Cite

Stomach

Chapter · March 28, 2012 Cite

A phase I/II study of capecitabine (Cape), oxaliplatin (Ox), panitumumab (Pmab), and external beam radiation therapy (RT) for patients with esophagogastric carcinoma (EC).

Journal Article J Clin Oncol · February 2012 68 Background: EC is commonly managed with concurrent chemoradiotherapy, with or without surgical resection. The optimal combination and dose of agents is the subject of continued investigation. This study examines chemotherapeutic agents with known effica ... Link to item Cite

Patterns of failure following trimodality therapy for locally advanced esophageal cancer (EC).

Journal Article J Clin Oncol · February 2012 88 Background: Patterns of local-regional failure (LRF) after neoadjuvant chemoradiotherapy (CRT) and surgery for locally-advanced EC are poorly defined. METHODS: This study reviewed pts treated with CRT followed by surgery for M0 esophageal cancer from 19 ... Link to item Cite

A phase I/II study of capecitabine (Cape), oxaliplatin (Ox), panitumumab (Pmab), and external beam radiation therapy (RT) for patients with esophagogastric carcinoma (EC).

Conference Journal of Clinical Oncology · February 1, 2012 68 Background: EC is commonly managed with concurrent chemoradiotherapy, with or without surgical resection. The optimal combination and dose of agents is the subject of continued investigation. This study examines chemotherapeut ... Full text Cite

Patterns of failure following trimodality therapy for locally advanced esophageal cancer (EC).

Conference Journal of Clinical Oncology · February 1, 2012 88 Background: Patterns of local-regional failure (LRF) after neoadjuvant chemoradiotherapy (CRT) and surgery for locally-advanced EC are poorly defined. Methods: This study reviewed pts treated with CRT followe ... Full text Cite

Intraoperative Irradiation

Chapter · January 1, 2012 Full text Cite

IMRT treatment of anal cancer with a scrotal shield.

Journal Article Med Dosim · 2012 Featured Publication The risk of sterility in males undergoing radiotherapy in the pelvic region indicates the use of a shielding device, which offers protection to the testes for patients wishing to maintain fertility. The use of such devices in the realm of intensity-modulat ... Full text Link to item Cite

Radiotherapy in the treatment of patients with unresectable extrahepatic cholangiocarcinoma.

Journal Article Int J Radiat Oncol Biol Phys · November 1, 2011 Featured Publication PURPOSE: Extrahepatic cholangiocarcinoma is an uncommon but lethal malignancy. We analyzed the role of definitive chemoradiotherapy for patients with nonmetastatic, locally advanced extrahepatic cholangiocarcinoma treated at a single institution. METHODS A ... Full text Link to item Cite

Role of radiation therapy in patients with resectable pancreatic cancer

Journal Article Oncology · August 12, 2011 The 5-year overall survival of patients with pancreatic cancer is approximately 5%, with potentially resectable disease representing the curable minority. Although surgical resection remains the cornerstone of treatment, local and distant failure rates are ... Cite

Beyond 5-fluorouracil: the emerging role of newer chemotherapeutics and targeted agents with radiation therapy.

Journal Article Semin Radiat Oncol · July 2011 Featured Publication The management of rectal cancer has undergone significant evolution with advances in surgery, radiation therapy, and chemotherapy. These advances have translated into improved rates of local control, survival, and quality of life. More recently, the integr ... Full text Link to item Cite

Introduction: current controversies in rectal cancer.

Journal Article Semin Radiat Oncol · July 2011 Featured Publication Full text Link to item Cite

Role of radiation therapy in patients with resectable pancreatic cancer.

Journal Article Oncology (Williston Park) · July 2011 Featured Publication The 5-year overall survival of patients with pancreatic cancer is approximately 5%, with potentially resectable disease representing the curable minority. Although surgical resection remains the cornerstone of treatment, local and distant failure rates are ... Link to item Cite

Update on treatment advances in combined-modality therapy for anal and rectal carcinomas.

Journal Article Curr Oncol Rep · June 2011 Featured Publication Concurrent radiation therapy and chemotherapy is the primary treatment for patients with squamous cell tumors of the anal canal, and is also employed in the neoadjuvant setting for patients with stage II and III adenocarcinoma of the rectum. There is const ... Full text Link to item Cite

Rectal cancer: A moving target?

Journal Article Practical Radiation Oncology · April 1, 2011 Full text Cite

Carcinoma of the ampulla of Vater: Patterns of failure after resection and benefit of adjuvant radiotherapy.

Journal Article Journal of Clinical Oncology · February 1, 2011 254 Background: Ampullary carcinoma is a rare malignancy. Despite radical resection, survival rates remain low with high rates of local failure. To define the role of radiation therapy and chemotherapy with surgery, we performed ... Full text Cite

Single-institution experience of preoperative chemoradiotherapy for locally advanced gastric cancer.

Journal Article Journal of Clinical Oncology · February 1, 2011 99 Background: To examine acute toxicity and outcomes for patients treated with preoperative chemoradiotherapy (CRT) for gastric cancer. Methods: Patients with gastroesophageal (GE) junction (Siewert type II and ... Full text Cite

Resected pancreatic neuroendocrine tumors: Patterns of failure and disease-related outcomes with or without radiotherapy.

Conference Journal of Clinical Oncology · February 1, 2011 325 Background: Pancreatic neuroendocrine tumors (NET) are rare with improved prognosis compared to adenocarcinomas. Surgical resection remains the standard of care although many patients present with unresectable/metastatic dise ... Full text Cite

Multicenter evaluation of adjuvant therapy for gallbladder cancer.

Journal Article Journal of Clinical Oncology · February 1, 2011 251 Background: To assess the effect of adjuvant therapy in gallbladder adenocarcinoma (GBC). Methods: Retrospective review was conducted at five institutions to identify pts who had surgery for confirmed dx of ... Full text Cite

A phase I study of erlotinib, bevacizumab, and external beam radiation therapy (RT) for patients with localized pancreatic carcinoma (PC).

Journal Article Journal of Clinical Oncology · February 1, 2011 281 Background: Localized PC is commonly managed with chemoradiotherapy, with or without surgical resection. The optimal combination of agents and doses is the subject of continued investigation. This phase I study examines the c ... Full text Cite

A phase I study of erlotinib, bevacizumab, and external beam radiation therapy (RT) for patients with localized pancreatic carcinoma (PC).

Journal Article J Clin Oncol · February 2011 281 Background: Localized PC is commonly managed with chemoradiotherapy, with or without surgical resection. The optimal combination of agents and doses is the subject of continued investigation. This phase I study examines the combination of two targeted ... Link to item Cite

Carcinoma of the ampulla of Vater: Patterns of failure after resection and benefit of adjuvant radiotherapy.

Journal Article J Clin Oncol · February 2011 254 Background: Ampullary carcinoma is a rare malignancy. Despite radical resection, survival rates remain low with high rates of local failure. To define the role of radiation therapy and chemotherapy with surgery, we performed a single institution analys ... Link to item Cite

Single-institution experience of preoperative chemoradiotherapy for locally advanced gastric cancer.

Journal Article J Clin Oncol · February 2011 99 Background: To examine acute toxicity and outcomes for patients treated with preoperative chemoradiotherapy (CRT) for gastric cancer. METHODS: Patients with gastroesophageal (GE) junction (Siewert type II and III) or stomach adenocarcinoma who underwent ... Link to item Cite

Resected pancreatic neuroendocrine tumors: Patterns of failure and disease-related outcomes with or without radiotherapy.

Journal Article J Clin Oncol · February 2011 325 Background: Pancreatic neuroendocrine tumors (NET) are rare with improved prognosis compared to adenocarcinomas. Surgical resection remains the standard of care although many patients present with unresectable/metastatic disease. While many resected pa ... Link to item Cite

Multicenter evaluation of adjuvant therapy for gallbladder cancer.

Journal Article J Clin Oncol · February 2011 251 Background: To assess the effect of adjuvant therapy in gallbladder adenocarcinoma (GBC). METHODS: Retrospective review was conducted at five institutions to identify pts who had surgery for confirmed dx of GBC from 1985-2008 (N = 189). Pts were exclud ... Link to item Cite

Colon Cancer

Chapter · January 1, 2011 Full text Cite

SU‐E‐T‐419: Clinical Protocol for the Use of Scrotal Shields in IMRT Treatment of Anal Cancer

Conference Medical Physics · January 1, 2011 Purpose: To implement a clinical protocol for the use of scrotal shields for anal cancer IMRT treatment. Methods and Results: (1) Simulation The patient is immobilized in a full‐body alpha‐cradle mold in the frog‐leg position. Further, the mold is built up ... Full text Cite

Intraoperative Irradiation

Chapter · January 1, 2011 Full text Cite

Intensity-modulated radiation therapy for anal malignancies: a preliminary toxicity and disease outcomes analysis.

Journal Article Int J Radiat Oncol Biol Phys · December 1, 2010 Featured Publication PURPOSE: Intensity-modulated radiation therapy (IMRT) has the potential to reduce toxicities associated with chemoradiotherapy in the treatment of anal cancer. This study reports the results of using IMRT in the treatment of anal cancer. METHODS AND MATERI ... Full text Link to item Cite

Adjuvant radiation therapy for distal pancreatic cancer: is there a role?

Journal Article Ann Surg Oncol · December 2010 Featured Publication Full text Link to item Cite

Neoadjuvant Chemoradiotherapy for Locally Advanced Gastric Adenocarcinoma: A Single Institution Experience

Conference International Journal of Radiation Oncology*Biology*Physics · November 2010 Full text Cite

Resected Pancreatic Neuroendocrine Tumors: Patterns of Failure and Disease-related Outcomes with or without Radiotherapy

Conference International Journal of Radiation Oncology*Biology*Physics · November 2010 Full text Cite

Intensity-modulated radiation therapy for anal cancer: toxicity versus outcomes.

Journal Article Oncology (Williston Park) · August 2010 Featured Publication The treatment of cancer of the anal canal has changed significantly over the past several decades. Although the abdominoperineal resection (APR) was the historical standard of care, a therapeutic paradigm shift occurred with the seminal work of Nigro, who ... Link to item Cite

Intensity-modulated radiation therapy for anal cancer: toxicity versus outcomes.

Journal Article Oncology (Williston Park, N.Y.) · August 1, 2010 The treatment of cancer of the anal canal has changed significantly over the past several decades. Although the abdominoperineal resection (APR) was the historical standard of care, a therapeutic paradigm shift occurred with the seminal work of Nigro, who ... Cite

Epigenetic markers in rectal cancer.

Journal Article Clin Cancer Res · May 15, 2010 Featured Publication DNA methylation changes in rectal cancer may serve as a new screening marker and a tool for monitoring recurrence. Importantly, these changes may also function as a predictive marker to allow appropriate exclusion of (neo)adjuvant therapies in patients at ... Full text Link to item Cite

Current and emerging treatment strategies for anal cancer.

Journal Article Curr Oncol Rep · May 2010 Featured Publication Concurrent radiotherapy and chemotherapy (5-fluorouracil and mitomycin-C) is established as a sphincter-preserving treatment for squamous cell carcinoma of the anal canal. However, there is room for improvement in rates of tumor control as well as a need t ... Full text Link to item Cite

Abstract LB-213: Plasma soluble VEGFR1 is a potential dual biomarker of response and toxicity for bevacizumab with chemoradiation in locally advanced rectal cancer

Journal Article Cancer Research · April 15, 2010 AbstractWe explored plasma and urinary concentration of four members of the vascular endothelial growth factor (VEGF) family as potential response and toxicity biomarker of bevacizumab with neoadjuvant chemo ... Full text Cite

Nonoperative management of rectal cancer: current perspectives.

Journal Article Clin Colorectal Cancer · April 2010 Featured Publication While surgery plays a central role in the management of all stages of operable rectal cancer, nonoperative approaches for both early-stage and locally advanced disease are being explored. This comprehensive review summarizes the current literature regardin ... Full text Link to item Cite

Radiation Injury

Chapter · January 1, 2010 Full text Cite

Radiation therapy advances for treatment of anal cancer.

Journal Article J Natl Compr Canc Netw · January 2010 Featured Publication Radiation therapy (RT) is established as the primary treatment of squamous cell carcinoma of the anus. Multiple randomized trials have shown that combined modality therapy with RT, 5-fluorouracil, and mitomycin-C results in high rates of local control, dis ... Full text Link to item Cite

A safety and survival analysis of neoadjuvant bevacizumab with standard chemoradiation in a phase I/II study compared with standard chemoradiation in locally advanced rectal cancer.

Journal Article Oncologist · 2010 Featured Publication INTRODUCTION: Bevacizumab is increasingly being tested with neoadjuvant regimens in patients with localized cancer, but its effects on metastasis and survival remain unknown. This study examines the long-term outcome of clinical stage II/III rectal cancer ... Full text Link to item Cite

Plasma soluble VEGFR-1 is a potential dual biomarker of response and toxicity for bevacizumab with chemoradiation in locally advanced rectal cancer.

Journal Article Oncologist · 2010 Featured Publication We explored plasma and urinary concentrations of two members of the vascular endothelial growth factor (VEGF) family and their receptors as potential response and toxicity biomarkers of bevacizumab with neoadjuvant chemoradiation in patients with localized ... Full text Link to item Cite

Intensity-modulated radiation therapy for anal cancer.

Journal Article Oncology (Williston Park) · November 15, 2009 Featured Publication The contemporary treatment of anal cancer is combined-modality therapy with radiation therapy, fluorouracil, and mitomycin. This therapy results in long-term disease-free survival and sphincter preservation in the majority of patients. Tempering these posi ... Link to item Cite

Multimodality therapy for locoregional extrahepatic cholangiocarcinoma: a population-based analysis.

Journal Article Cancer · November 15, 2009 Featured Publication BACKGROUND: Although surgical resection is the mainstay of treatment for extrahepatic cholangiocarcinoma, the majority of patients present with advanced disease. Due in part to numeric rarity, the optimum role of radiotherapy (RT) for extrahepatic cholangi ... Full text Link to item Cite

Intensity-modulated radiation therapy for anal cancer

Journal Article ONCOLOGY · November 15, 2009 The contemporary treatment of anal cancer is combined-modality therapy with radiation therapy, fluorouracil, and mitomycin. This therapy results in long-term disease-free survival and sphincter preservation in the majority of patients. Tempering these posi ... Cite

Potential Benefit of Radiation Therapy in Resectable Anorectal Melanoma

Conference International Journal of Radiation Oncology*Biology*Physics · November 2009 Full text Cite

Intensity Modulated Radiation Therapy (IMRT) for Anal Cancer: The Duke University Experience

Conference International Journal of Radiation Oncology*Biology*Physics · November 2009 Full text Cite

Direct evidence that bevacizumab, an anti-VEGF antibody, up-regulates SDF1alpha, CXCR4, CXCL6, and neuropilin 1 in tumors from patients with rectal cancer.

Journal Article Cancer Res · October 15, 2009 Featured Publication Clinical studies converge on the observation that circulating cytokines are elevated in most cancer patients by anti-vascular endothelial growth factor (VEGF) therapy. However, the source of these molecules and their relevance in tumor escape remain unknow ... Full text Link to item Cite

Chemoradiotherapy in gastrointestinal malignancies.

Journal Article Clin Oncol (R Coll Radiol) · September 2009 Featured Publication Over the past 30 years, significant advances have been made in the integration of radiation therapy and chemotherapy in the treatment of patients with localised gastrointestinal malignancies. The therapeutic goal of chemoradiotherapy is to enhance local co ... Full text Link to item Cite

Accomplishments in 2008 in the adjuvant treatment of rectal cancer.

Journal Article Gastrointest Cancer Res · September 2009 Featured Publication Overview of the Disease IncidencePrognostic FactorsCurrent General Therapy Standards Surgery(Neo) Adjuvant Radiotherapy and ChemotherapyAccomplishments During the Year Time Duration Between Radiotherapy and SurgeryHistopathology Post-Neoadjuvant TherapyMet ... Link to item Cite

Efficacy, safety, and biomarkers of neoadjuvant bevacizumab, radiation therapy, and fluorouracil in rectal cancer: a multidisciplinary phase II study.

Journal Article J Clin Oncol · June 20, 2009 Featured Publication PURPOSE: To assess the safety and efficacy of neoadjuvant bevacizumab with standard chemoradiotherapy in locally advanced rectal cancer and explore biomarkers for response. PATIENTS AND METHODS: In a phase I/II study, 32 patients received four cycles of th ... Full text Link to item Cite

Current management of anal canal cancer.

Journal Article Curr Oncol Rep · May 2009 Featured Publication Squamous cell carcinoma of the anal canal historically has been treated with abdominoperineal resection, resulting in high rates of morbidity and local recurrence. Pioneering work led to the finding that radiation therapy (RT) combined with 5-fluorouracil ... Full text Link to item Cite

Metastatic Liver Cancer: Treatment: Radiation therapy

Journal Article · January 14, 2009 The liver is the most common site for blood-borne metastasis from colorectal cancers. Until the early 1980s, it was generally accepted that hepatic metastases from colorectal cancer represented just one site in a wide systemic dissemination of tumor, and h ... Full text Cite

Concurrent chemoradiotherapy in resected extrahepatic cholangiocarcinoma.

Journal Article Int J Radiat Oncol Biol Phys · January 1, 2009 Featured Publication PURPOSE: Extrahepatic cholangiocarcinoma is a rare malignancy. Despite radical resection, survival remains poor, with high rates of local and distant failure. To clarify the role of radiotherapy with chemotherapy, we performed a retrospective analysis of r ... Full text Link to item Cite

Neoadjuvant Chemoradiation for Rectal Cancer

Journal Article Seminars in Colon and Rectal Surgery · December 1, 2008 Significant advances have been made in the treatment of rectal cancer patients. Phase III studies have demonstrated the efficacy of neoadjuvant and adjuvant radiation therapy and chemotherapy in improving the outcome of patients with locally advanced disea ... Full text Cite

Thirty years of rectal cancer research: a brief history.

Journal Article Oncology (Williston Park) · November 15, 2008 Featured Publication Link to item Cite

Intensity-modulated radiation therapy for gastrointestinal tumors.

Journal Article Curr Oncol Rep · May 2008 Featured Publication Radiation plays an important role in the multimodal management of tumors of the gastrointestinal (GI) system. Intensity-modulated radiation therapy (IMRT) is a technological development that was introduced to limit the acute and late toxicities commonly as ... Full text Link to item Cite

Emerging role of intensity-modulated radiation therapy in anorectal cancer.

Journal Article Expert Rev Anticancer Ther · April 2008 Featured Publication Although radiation therapy has an established role to play in the management of rectal and anal tumors, there are often treatment-related morbidities that negatively impact on patients. There is a long-standing interest in radiation oncology on maximizing ... Full text Link to item Cite

Is there a role for advanced radiation therapy technologies in the treatment of pancreatic adenocarcinoma?

Journal Article Future Oncol · April 2008 Featured Publication Pancreatic cancer remains a highly challenging problem in oncology. Oncologists continue to search for therapies that are more effective than those currently available to improve on the existing poor treatment results. Persistence of both systemic and loca ... Full text Link to item Cite

A phase I study of UFT/leucovorin, carboplatin, and paclitaxel in combination with external beam radiation therapy for advanced esophageal carcinoma.

Journal Article Int J Radiat Oncol Biol Phys · March 15, 2008 Featured Publication PURPOSE: Concurrent chemotherapy and radiation therapy (RT) are used to treat patients with esophageal cancer. The optimal combination of chemotherapeutic agents with RT is not well established. We evaluated the safety and preliminary efficacy of a combina ... Full text Link to item Cite

Duodenal adenocarcinoma: patterns of failure after resection and the role of chemoradiotherapy.

Journal Article Int J Radiat Oncol Biol Phys · December 1, 2007 Featured Publication PURPOSE: To report patterns of disease recurrence after resection of adenocarcinoma of the duodenum and compare outcomes between patients undergoing surgery only vs. surgery with concurrent chemotherapy and radiation therapy (CT-RT). METHODS AND MATERIALS: ... Full text Link to item Cite

Radiation therapy in stage II and III rectal cancer.

Journal Article Clin Cancer Res · November 15, 2007 Featured Publication Over the past 25 years, significant advances have been made in the management of patients with rectal cancer. Phase III studies have shown the efficacy of postoperative radiation therapy and chemotherapy in improving local control and survival of patients ... Full text Link to item Cite

Commentary: rectal cancer an evolution of treatment.

Journal Article Oncologist · November 2007 Featured Publication Full text Link to item Cite

Paclitaxel-based chemoradiotherapy in the treatment of patients with operable esophageal cancer.

Journal Article Int J Radiat Oncol Biol Phys · November 1, 2007 Featured Publication PURPOSE: To compare a neoadjuvant regimen of cisplatin/5-fluorouracil (5-FU) and concurrent radiation therapy (RT) with paclitaxel-based regimens and RT in the management of operable esophageal (EC)/gastroesophageal junction (GEJ) cancer. METHODS AND MATER ... Full text Link to item Cite

Concurrent Chemoradiation for Resectable Extrahepatic Cholangiocarcinoma

Conference International Journal of Radiation Oncology*Biology*Physics · November 2007 Full text Cite

Combined-modality therapy for rectal cancer: future prospects.

Journal Article Clin Colorectal Cancer · September 2007 Featured Publication The management of rectal cancer has undergone significant evolution with advances in surgery, radiation therapy, and chemotherapy. These advances have translated into improved rates of local control, survival, and quality of life. More recently, the integr ... Full text Link to item Cite

Targeted therapy in rectal cancer.

Journal Article Oncology (Williston Park) · August 2007 Featured Publication Epidermal growth factor receptor (EGFR) and vascular endothelial growth factor (VEGF) are often overexpressed in colorectal cancer and are associated with inferior outcomes. Based on successful randomized phase III trials, anti-EGFR and anti-VEGF therapeut ... Link to item Cite

Bevacizumab, oxaliplatin, and capecitabine with radiation therapy in rectal cancer: Phase I trial results.

Journal Article Int J Radiat Oncol Biol Phys · June 1, 2007 Featured Publication PURPOSE: The overexpression of vascular endothelial growth factor (VEGF) is associated with poor outcomes in colorectal cancer patients. Bevacizumab, a VEGF inhibitor, enhances the effects of chemotherapy and radiation therapy on tumor cytotoxicity in prec ... Full text Link to item Cite

Complete pathological response to bevacizumab and chemoradiation in advanced rectal cancer.

Journal Article Nat Clin Pract Oncol · May 2007 Featured Publication BACKGROUND: Localized rectal cancer responds well to 5-fluorouracil and radiation-based regimens. A phase I-II trial is currently testing the efficacy of adding bevacizumab, a VEGF-specific antibody, to standard chemoradiotherapy. The case presented here i ... Full text Link to item Cite

A Phase I study of capecitabine, carboplatin, and paclitaxel with external beam radiation therapy for esophageal carcinoma.

Journal Article Int J Radiat Oncol Biol Phys · March 15, 2007 Featured Publication PURPOSE: Concurrent chemotherapy and radiation therapy (RT) are used to treat patients with esophageal cancer. The optimal combination of chemotherapeutic agents with RT is undefined. We evaluated a combination of capecitabine, carboplatin, and paclitaxel ... Full text Link to item Cite

Intraoperative radiation therapy.

Journal Article J Clin Oncol · March 10, 2007 Featured Publication Intraoperative radiation therapy (IORT) is the delivery of irradiation at the time of an operation. This is performed by different techniques including intraoperative electron beam techniques and high-dose rate brachytherapy. IORT is usually given in combi ... Full text Link to item Cite

Contemporary management of rectal cancer: new standards, mounting questions, emerging challenges.

Journal Article Gastrointest Cancer Res · March 2007 Featured Publication Link to item Cite

Adjuvant therapy of pancreatic cancer.

Journal Article Cancer J · 2007 Featured Publication Of the 33,370 patients diagnosed with pancreatic carcinoma in the United States this year, approximately 20% will present with resectable disease. At present, surgery offers the only means of cure. Radiation therapy and chemotherapy approaches have been us ... Full text Link to item Cite

Particle radiation therapy for gastrointestinal malignancies.

Journal Article Gastrointest Cancer Res · 2007 Featured Publication Treatment-related toxicity is common in the radiotherapeutic management of cancers of the gastrointestinal tract. These toxicities can diminish treatment efficacy by necessitating treatment breaks, limiting the radiation dose that can be delivered, and hin ... Link to item Cite

Advanced radiation therapy technologies in the treatment of rectal and anal cancer: intensity-modulated photon therapy and proton therapy.

Journal Article Clin Colorectal Cancer · January 2007 Featured Publication Intensity-modulated photon radiation therapy (RT; IMRT) and proton therapy are advanced radiation technologies that permit improved conformation of radiation dose to target structures while limiting irradiation of surrounding normal tissues. Application of ... Full text Link to item Cite

TH‐E‐M100F‐07: Amplitude Gated Breath‐Hold Treatment for Upper Abdominal Lesions with On Board Imaging Guidance

Conference Medical Physics · January 1, 2007 Purpose: To apply on‐boardmdash;image (OBI) guided amplitude gating for breath‐hold treatment and to assess treatment margin adequacy by analyzing the isocenter placement based on orthogonal 2D kV radiographs and 3D cone‐beam CT (CBCT) acquired under ampli ... Full text Cite

2147

Conference International Journal of Radiation Oncology*Biology*Physics · November 2006 Full text Cite

2136

Conference International Journal of Radiation Oncology*Biology*Physics · November 2006 Full text Cite

Radiation therapy in the treatment of cholangiocarcinoma.

Journal Article Oncology (Williston Park) · July 2006 Featured Publication The prognosis of patients with biliary cancers is poor. Although surgery is potentially curative in selected patients, local recurrence is a common pattern of failure. Adjuvant or neoadjuvant radiation therapy improves local control and possibly survival. ... Link to item Cite

A phase I study of capecitabine (CAP), carboplatin (CARB), paclitaxel (TAX) and external beam radiation therapy (EBRT) for patients with esophageal carcinoma (EC).

Journal Article J Clin Oncol · June 20, 2006 14044 Background: Chemoradiotherapy is used to treat esophageal cancer with curative intent or local symptom control. A phase I study of 5-FU + CARB + TAX + EBRT showed 100% RR and 50% pCR rate. CAP allows for fluoropyrimidine treatment without the inconve ... Link to item Cite

Radiation therapy for resectable colon cancer. Is there a role in the modern chemotherapy era?

Journal Article Oncology (Williston Park) · February 2006 Featured Publication Colon cancer is a major public health problem. The primary treatment is resection. For patients with early-stage disease, surgery results in excellent survival rates. In contrast, patients with locally advanced tumors arising in "anatomically immobile" seg ... Link to item Cite

Increased toxicity with gefitinib, capecitabine, and radiation therapy in pancreatic and rectal cancer: phase I trial results.

Journal Article J Clin Oncol · February 1, 2006 Featured Publication PURPOSE: Overexpression of epidermal growth factor receptor (EGFR) has been associated with aggressive tumor phenotypes, chemotherapy, and radiation resistance, as well as poor survival in preclinical and clinical models. The EGFR inhibitor gefitinib poten ... Full text Link to item Cite

A phase I study of eniluracil/5-FU in combination with radiation therapy for potentially resectable and/or unresectable cancer of the pancreas and distal biliary tract.

Journal Article Cancer Invest · February 2006 Featured Publication PURPOSE: Eniluracil is an effective inactivator of dihydropyrimidine dehydrogenase (DPD). It allows for oral dosing of 5-fluorouracil (5-FU), which may potentially improve the antitumor activity of 5-FU when delivered concurrently with radiotherapy while a ... Full text Link to item Cite

The Chadha/Kuvshinoff/Javle article reviewed

Journal Article ONCOLOGY · December 1, 2005 Cite

The Pisters/Wolff/Crane et al article reviewed

Journal Article ONCOLOGY · December 1, 2005 Cite

Carcinoma of the Ampulla of Vater: Patterns of Failure After Resection and Possible Benefit of Adjuvant Radiotherapy

Conference International Journal of Radiation Oncology*Biology*Physics · October 2005 Full text Cite

Adjuvant external-beam radiotherapy with concurrent chemotherapy after resection of primary gallbladder carcinoma: a 23-year experience.

Journal Article Int J Radiat Oncol Biol Phys · July 15, 2005 PURPOSE: Primary adenocarcinoma of the gallbladder is a rare malignancy. To better define the role of adjuvant radiation therapy and chemotherapy, a retrospective analysis of the outcome of patients undergoing surgery and adjuvant therapy was undertaken. M ... Full text Link to item Cite

Locally advanced pancreatic cancer.

Journal Article J Clin Oncol · July 10, 2005 Of the 32,180 patients diagnosed with pancreatic carcinoma in the United States this year, approximately 40% will present with locally advanced disease. Radiotherapeutic approaches are often employed because these patients have unresectable tumors by virtu ... Full text Link to item Cite

Significance of histological response to preoperative chemoradiotherapy for pancreatic cancer.

Journal Article Ann Surg Oncol · March 2005 BACKGROUND: Neoadjuvant (preoperative) chemoradiotherapy (CRT) for pancreatic cancer offers theoretical advantages over the standard approach of surgery followed by adjuvant CRT. We hypothesized that histological responses to CRT would be significant progn ... Full text Link to item Cite

Adjuvant radiotherapy with and without concurrent chemotherapy for locally advanced transitional cell carcinoma of the renal pelvis and ureter.

Journal Article J Urol · October 2004 PURPOSE: Transitional cell carcinoma of the upper urinary tract is a relatively uncommon malignancy. The role of adjuvant radiation therapy and chemotherapy is not well defined. We retrospectively reviewed the records of 31 patients who underwent surgery f ... Full text Link to item Cite

Complications of pancreaticoduodenectomy after neoadjuvant chemoradiation in patients with and without preoperative biliary drainage.

Journal Article Dig Liver Dis · June 2004 BACKGROUND: It has been suggested that preoperative biliary drainage increases the risk of infectious complications of pancreaticoduodenectomy. AIMS: The aim of this study was to assess complications related to biliary stents/drains and postoperative morbi ... Full text Link to item Cite

A Phase I trial of preoperative eniluracil plus 5-fluorouracil and radiation for locally advanced or unresectable adenocarcinoma of the rectum and colon.

Journal Article Int J Radiat Oncol Biol Phys · March 1, 2004 PURPOSE: Eniluracil, an effective inactivator of dihydropyrimidine dehydrogenase, allows for oral dosing of 5-fluorouracil (5-FU), which avoids the morbidity of continuous infusion 5-FU. We addressed the safety of oral eniluracil and 5-FU combined with pre ... Full text Link to item Cite

Current perspectives on locally advanced pancreatic cancer.

Journal Article Oncology (Williston Park) · November 2000 This year, approximately 40% of the 28,300 patients diagnosed with pancreatic carcinoma in the United States will present with locally advanced disease. Radiotherapeutic approaches are often employed, as these patients have unresectable tumors by virtue of ... Link to item Cite